NYSGXRC-93e SGX Pharmaceuticals 2000-12-19 active Selected Cloned Expressed Soluble Purified ThiI ICEDB: T1422 GENBANK NP_414957.1 MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHI LEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVH LEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHY LWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNL RLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVV EEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSIDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNKT WLLWCERGVMSRLQALYLREQGFNNVKVYRP Escherichia coli NYSGXRC-99c SGX Pharmaceuticals 2003-04-01 active Selected Cloned Expressed Soluble Purified fliD ICEDB: T823 GENBANK NP_416434.1 MASISSLGVGSGLDLSSILDSLTAAQKATLTPISNQQSSFTAKLSAYGTLKSALTTFQTANTALSKADLFSATSTT SSTTAFSATTAGNAIAGKYTISVTHLAQAQTLTTRTTRDDTKTAIATSDSKLTIQQGGDKDPITIDISAANSSLS GIRDAINNAKAGVSASIINVGNGEYRLSVTSNDTGLDNAMTLSVSGDDALQSFMGYDASASSNGMEVSVAAQNAQ LTVNNVAIENSSNTISDALENITLNLNDVTTGNQTLTITQDTSKAQTAIKDWVNAYNSLIDTFSSLTKYTAVDAG ADSQSSSNGALLGDSTLRTIQTQLKSMLSNTVSSSSYKTLAQIGITTDPSDGKLELDADKLTAALKKDASGVGAL IVGDGKKTGITTTIGSNLTSWLSTTGIIKAATDGVSKTLNKLTKDYNAASDRIDAQVARYKEQFTQLDVLMTSLN STSSYLTQQFENNSNSK Escherichia coli NYSGXRC-114h SGX Pharmaceuticals 2001-04-12 active Selected Cloned Expressed Soluble Purified yvqK ICEDB: T774 GENBANK NP_253089.1 MGNRLSKIYTRTGDRGETGLAGGRRVPKSHPRIEAIGAVDELNSQLGLLLAELLEARGAHPGLEEIVQALAPVQHR LFDLGGELAMPEYRALDETEVARLESCIDRWNDELGPLKNFILPGGSRPVAQAHVCRSLARSAERRCQALDQEET LEGVGLRYLNRLSDLLFVAARAIARRQGVAEILWEAAAKPD Pseudomonas aeruginosa NYSGXRC-125h SGX Pharmaceuticals 2004-06-07 active Selected Cloned Expressed Soluble Purified Yjbn GENBANK NP_229531.1 PFAM PF01513 KIAILYREEREKEGEFLKEKISKEHEVIEFGEANAPGRVTADLIVVVGGDGTVLKAAKKAADGTPMVGFKAGRLGF LTSYTLDEIDRFLEDLRNWNFREETRWFIQIESELGNHLALNDVTLERDLSGKMVEIEVEVEHHSSMWFFADGVV ISTPTGSTAYSLSIGGPIIFPECEVLEISPIAPQFFLTRSVVIPSNFKVVVESQRDINMLVDGVLTGKTKRIEVK KSRRYVRILRPPEYDYVTVIRDKLGYGRRIE Thermotoga maritima NYSGXRC-127o SGX Pharmaceuticals 2003-11-25 active Selected Cloned Expressed Soluble Purified FliC ICEDB: T1766 GENBANK NP_231774.1 PFAM PF01513 MAVNVNTNVAAMTAQRYLTGATNAQQTSMERLSSGFKINSAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQ TAEGAMNETTNILQRMRDLSLQSANGSNSKSERVAIQEEITALNDELNRIAETTSFGGNKLLNGTFSTKSFQIGA DNGEAVMLTLKDMRSDNRMMGGTSYVAAEGKDKDWKVQAGANDITFTLKDIDGNDQTITVNAKEGDDIEEVATYI NGQTDMVKASVNEKGQLQIFAGNNKVTGDVAFSGGLAGALNMQAGTAETVDTIDVTSVGGAQQSVAVIDSALKYV DSHRAELGAFQNRFNHAISNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALSLL G Vibrio cholerae NYSGXRC-149a SGX Pharmaceuticals 2001-01-10 active Selected Cloned Expressed Soluble Purified Scp2 ICEDB: T775 GENBANK NP_388172.1 TISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDSSVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHS GDNLTGAGEGDDENVKVNLSAVPANIDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSI ETAIIAGELYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG Bacillus subtilis NYSGXRC-157d SGX Pharmaceuticals 2004-10-27 active Selected Cloned Expressed Soluble Purified YadR ICEDB: T767 GENBANK NP_285852.1 SDDVALPLEFTDAAANKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQ YLVGGSVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI Escherichia coli NYSGXRC-158i SGX Pharmaceuticals 2001-04-18 active Selected Cloned Expressed Soluble Purified LrpC ICEDB: T1431 GENBANK NP_251267.1 MTDDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRPLPGR LHEVERQIQDIAEFTECDKVTGDDCFIARLQVRSMEQLDTLLDRINGYAETNTAIVKKSPVKRRLPPMT Pseudomonas aeruginosa NYSGXRC-166d SGX Pharmaceuticals 2001-07-06 active Selected Cloned Expressed Soluble Purified YicC ICEDB: T1007, T800 GENBANK NP_229491.1 IKSMTGFSRVEKVSGPYQFRVEMKSLNSKGLNIINQLPGYLSMKEIELNNLVQEYVSRGKVQTRVQVKFLEPPKVL EIDKNVVRAYYSMLDEIVGELSLPEPVKLSDLLNFREVFRIELSDEEIENIWNHLVPILREALEKLVEERKKEGQ KIGADLKRILEDLSSRVEEIEKISDQLPALYREKIKEEVEKILPQDVSVKEDILENHVAFMATKADIREEITRLR SHIKRALELIESDEPVGMNLDFLGQEMLRELNTILSKSISGEITSLALEGKVLVSQFREQIQNVE Thermotoga maritima NYSGXRC-168b SGX Pharmaceuticals 2003-07-17 active Selected Cloned Expressed Soluble Purified MtlD ICEDB: T798 GENBANK NP_418057.1 KALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGDDVVDLI AQVDLVTTAVGPVVLERIAPAIAKGQVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGF VDSAVDRIVPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLG KLAGHQTIRDAILDEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLS AGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDANSEVVSEAVTA YKAMQ Escherichia coli NYSGXRC-172g SGX Pharmaceuticals 2001-01-08 active Selected Cloned Expressed Soluble Purified YyaN ICEDB: T825 GENBANK NP_415020.1 NISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHS ADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDDSADCPIIENLSGCCHHRAG Escherichia coli NYSGXRC-205a SGX Pharmaceuticals 2003-07-22 active Selected Cloned Expressed Soluble Purified yusI ICEDB: T1408 GENBANK NP_391160.1 SLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELKALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHM SEDEQLELLASDGMLIKRPLTTDGEKVTVGFKEDQFEENWA Bacillus subtilis NYSGXRC-214a SGX Pharmaceuticals 2001-01-08 active Selected Cloned Expressed Soluble Purified YXBB ICEDB: T1409, T975 GENBANK NP_391868.1 ITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMGTGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQE EAKKSGVSSLISFDLEDVHHLSYADQYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEI MRKQIKEPEYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQNDQSTDHEI ESVTWMLTIEKEKEGAL Bacillus subtilis NYSGXRC-225l SGX Pharmaceuticals 2001-01-16 active Selected Cloned Expressed Soluble Purified ybcQ ICEDB: T768 GENBANK NP_071235.1 DTPFIVFWELTRACMLACKHCRAKAIRKRHPDELTTEECFNVIDQLSEFNPKPLLIITGGDPLMRDDVTEIISHAA EKGFRVAIAFSGTEKATEEKLRELKEAGVARVAVSIDGSDEEKHDSFRGVRGTFRMSMMAIENAKKAGLPFQINT TVTRENIEDLPNIARLCLELGAVMWDVFFVVPTGRAKAEMMPTPQQFEDVLCWLYDLSKKTGLNVKSSAATHLRR IELMRDRGEMPAVGELYYRLLERIEDFPEGEGIVVAGGHGKSLSTDGIRRAIGITDGRGMFFISHIGEVYPSGFL PIVAGNVRNTSLKEIYYSSEIFVNLRDPDRLKGKCGRCEYRKICGGSRARAYAVHGDYLAEEPCCIYIPQSSR Archaeoglobus fulgidus NYSGXRC-279k SGX Pharmaceuticals 2001-05-04 active Selected Cloned Expressed Soluble Purified PHOL ICEDB: T1411 GENBANK NP_273886.1 THTVHLHLEETDNLALQRLCGSFDNNLDLLAKALDIHISRRFEHFTFNGAFAHAGKRALLKLLETAQTRDLNDGDI RLAAVEAQTEDAGHQEKNHDHAYYFRTKRGSIGGRTPRQNGYIRALLNHDIVFGLGPAGTGKTYLAVAAAVDAME KHQVERIILVRPAVEAGEKLGFLPGDLTQKVDPYLRPLYDALYDLMGFDRVTKLIEKGLIEIAPLAYMRGRTLNG AYIILDEAQNTTPEQMKMFLTRIGFGAKAVITGDTSQIDLPKNIKSGLKDAREKLHGVEGLYFHTFTGEDVVRHP LVQKIVEAYESAEHD Neisseria meningitidis NYSGXRC-283b SGX Pharmaceuticals 2001-01-24 active Selected Cloned Expressed Soluble Purified RBSD ICEDB: T772 GENBANK NP_438659.1 KTALLNAQLSHCIATLGHTESLTICDAGLPIPLSVERIDLALTAGVPSFLQTLNVVTNEMYVERVVIAEEIKEKNP EILTALLTQLQKLESHQGNQIQVEFVSHETFKKFTLESKAIVRTGECSPYANVILYSGVPF Haemophilus influenzae NYSGXRC-297d SGX Pharmaceuticals 2001-01-25 active Selected Cloned Expressed Soluble Purified CINA ICEDB: T826 GENBANK NP_228512.1 KKAAIITIGSELLEGLILNKNAQFLCQELKNLGYRVVKVSTVGDDLISISEEVKTLLLKVDLLILTGGLGPTQDDL TRDAVAKVLNRSLKLNEELLSKIKEKIKKYHSEIPQNIERQALVIDGAEVLDNPVGSAPGQLLTVDGKIVILLPG PPRELIPMFNALKDRLRTPDALYQVVLKYYSIPEAVLEDLLKDILYSQNIVEVATMADHVEGVRLRLTTHMKNKE YLDEMVKKILDKTGEHLYGVNDEKMEEVVVRLLKDRKKTLAVAESCTGGMLSSLVVNVPGASEVFIGGVVAYSND LKKHILGVREDTLKKHGAVSEECVQEMTEGLKKLTGADICVSISGIAGPSGGTPEKPVGTVFIDIFEHEHITMRY NFTGDRNMIRTRSAMMALENLRKYLKGRERV Thermotoga maritima NYSGXRC-303a SGX Pharmaceuticals 2001-01-19 active Selected Cloned Expressed Soluble Purified RIMM ICEDB: T757 GENBANK NP_389484.1 TKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFMDGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNE VEELKNAIIKVPEEELGELNEGEFYFHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESV VKHIDVREKKIEIELMEGLIDE Bacillus subtilis NYSGXRC-305a SGX Pharmaceuticals 2001-03-14 active Selected Cloned Expressed Soluble Purified GLPX ICEDB: T801 GENBANK NP_391590.1 ERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVFDTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYG PRVDVAVDPLEGTNILASGGWNALTVIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNK DVEDVVATILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSAVALKALGGE IIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGELLKGVQFKGSVGTTESLVIRAKSGTV RFVDGRHSLKKKPNLVIRP Bacillus subtilis NYSGXRC-306e SGX Pharmaceuticals 2003-04-29 active Selected Cloned Expressed Soluble Purified YIGZ ICEDB: T1413 GENBANK NP_275138.1 ITTYKTITSSTQAEFKDKGSRFIAFAYPIRTLADVKKYLDPLKEEHHKARHWCYAYRLGVDGMQFRANDDGEPSGS AGRPILGQIDSVGITDVLVVVVRYFGGTLLGVPGLIHAYKEATAQALAVAEVVEKNIEKTVWLKCEYPFLNEAIR IAKQYQADILERDLQLDCRLTVSLSLVNYEACVAAWKNTRQIEVNTEKPFE Neisseria meningitidis NYSGXRC-328i SGX Pharmaceuticals 2003-10-03 active Selected Cloned Expressed Soluble Purified F69768 ICEDB: T1596 GENBANK NP_389735.1 FPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESIEQAISMIQTFAALYQEKRGIRWGIERRDTKELI GTIGFHALAQKHRRAEIGYEIIPEHWRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEG VLRQYMYSKWDSI Bacillus subtilis NYSGXRC-347a SGX Pharmaceuticals 2006-10-17 active Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data YCDC ICEDB: T802 GENBANK NP_388896.1 SIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIFTTLLKEMKQKADEAMEPSLPF HENVHRALFAILEFRKTHQLTIKIFQENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFV MLKLYIALIFDWEKQHPPLDKETIAGLLELYVVKGLSAN Bacillus subtilis NYSGXRC-371g SGX Pharmaceuticals 2005-06-28 active Selected Cloned Expressed Soluble Purified YBHK ICEDB: T809 GENBANK NP_415301.1 RNRTLADLDRVVALGGGHGLGRVLSSLSSLGSRLTGIVTTTDNGGSTGRIRRSEGGIAWGDMRNCLNQLITEPSVA SAMFEYRFGGNGELSGHNLGNLMLKALDHLSVRPLEAINLIRNLLKVDTHLIPMSEHPVDLMAIDDQGHEVYGEV NIDQLTTPIQELLLTPNVPATREAVHAINEADLIIIGPGSFYTSLMPILLLKEIAQALRRTPAPMVYIGNLGREL SLPAANLKLESKLAIMEQYVGKKVIDAVIVGPKVDVSAVKERIVIQEVLEASDIPYRHDRQLLHNALEKALQALG Escherichia coli NYSGXRC-417f SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|Q60343|Y026_METJA ICEDB: T780 GENBANK NP_246989.1 MIVYKGEKMQFIRVNTLKINPEVLKKRLENKGVVLEKTFLDYAFEVKKSPFSIGSTPEYLFGYYMPQSISSMIPPI VLNPREDDFILDMCAAPGGKTTHLAQLMKNKGTIVAVEISKTRTKALKSNINRMGVLNTIIINADMRKYKDYLLK NEIFFDKILLDAPCSGNIIKDKNRNVSEEDIKYCSLRQKELIDIGIDLLKKDGELVYSTCSMEVEENEEVIKYIL QKRNDVELIIIKANEFKGINIKEGYIKGTLRVFPPNEPFFIAKLR Methanococcus jannaschii NYSGXRC-439f SGX Pharmaceuticals 2003-08-08 active Selected Cloned Expressed Soluble Purified pir||D72397 ICEDB: T827 GENBANK NP_414795.1 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRP RVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGI NCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD IAALKARS Escherichia coli NYSGXRC-442a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|Q08788|SRF4_BACSU ICEDB: T821 GENBANK NP_388234.1 SQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIEDLEELTDLYKQELNLRPD RPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEV MSFFLPSFRSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVA ERIFAILNQHPIIQP Bacillus subtilis NYSGXRC-448a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||H69778 ICEDB: T1415 GENBANK NP_388407.1 TKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQPRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAI LRFLEHLQLRKQLGGIILVSGFAKSLPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQI DAALYEVQHGGHFLEDEGFTSLPIVYDVLTSYFSKETR Bacillus subtilis NYSGXRC-453a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P37196|TREF_ECOLI ICEDB: T777 GENBANK NP_290099.1 LNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKT FPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPW SSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVF ALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVET AKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEAL FRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILAS EYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKLIEKYHIADGVPREGGGGEYP LQDGFGWTNGVVRRLIGLYGEP Escherichia coli NYSGXRC-455f SGX Pharmaceuticals 2007-04-20 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB pir||H72315 ICEDB: T834 GENBANK NP_228744.1 PDB 2PLM PDB 1P1M PFAM PF01979 IIGNCLILKDFSSEPFWGAVEIENGTIKRVLQGEVKVDLDLSGKLVMPALFNTHTHAPMTLLRGVAEDLSFEEWLF SKVLPIEDRLTEKMAYYGTILAQMEMARHGIAGFVDMYFHEEWIAKAVRDFGMRALLTRGLVDSNGDDGGRLEEN LKLYNEWNGFEGRIFVGFGPHSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDILNIGLKEVKTIAA HCVHLPERYFGVLKDIPFFVSHNPASNLKLGNGIAPVQRMIEHGMKVTLGTDGAASNNSLNLFFEMRLASLLQKA QNPRNLDVNTCLKMVTYDGAQAMGFKSGKIEEGWNADLVVIDLDLPEMFPVQNIKNHLVHAFSGEVFATMVAGKW IYFDGEYPTIDSEEVKRELARIEKELYSS Thermotoga maritima NYSGXRC-474a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P23872|AES_ECOLI ICEDB: T808 GENBANK NP_415009.1 KPENKLPVLDLISAEMKTVVNTLQPDLPPWPATGTIAEQRQYYTLERRFWNAGAPEMATRAYMVPTKYGQVETRLF CPQPDSPATLFYLHGGGFILGNLDTHDRIMRLLASYSQCTVIGIDYTLSPEARFPQAIEEIVAACCYFHQQAEDY QINMSRIGFAGDSAGAMLALASALWLRDKQIDCGKVAGVLLWYGLYGLRDSVTRRLLGGVWDGLTQQDLQMYEEA YLSNDADRESPYYCLFNNDLTREVPPCFIAGAEFDPLLDDSRLLYQTLAAHQQPCEFKLYPGTLHAFLHYSRMMK TADEALRDGAQFFTAQL Escherichia coli NYSGXRC-479c SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|Q58465|YA65_METJA ICEDB: T813 GENBANK NP_391666.1 AAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEAGADAVKFQMFQADRMYQKDPGLYKTAAGKDVSI FSLVQSMEMPAEWILPLLDYCREKQVIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFS TAGAEISDVHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHPTEAPCAAVR LGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGITKPVSEKLLGSSYKTTTAIEGEIRNFA YRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE Bacillus subtilis NYSGXRC-489h SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||G69349 ICEDB: T1430 GENBANK NP_228882.1 KRFLLISDSHVPVRMASLPDEILNSLKEYDGVIGLGDYVDLDTVILLEKFSKEFYGVHGNMDYPDVKEHLPFSKVL LVEGVTIGMCHGWGAPWDLKDRLLKVFNEKPQVILFGHTHEPEDTVKAGVRFLNPGSLAEGSYAVLELDGGEVRF ELKTL Thermotoga maritima NYSGXRC-494c SGX Pharmaceuticals 2001-10-05 active Selected Cloned Expressed Soluble Purified pir||G69347 ICEDB: T778 GENBANK NP_069617.1 IPCPSCGRELRAVVSTYDVPFFGKVLLTSISCECGFRHADSVVLGEKDPVRYIIKINRENLFTKVIRSTSGTIRIP EIGVAIEPGPASQAFITNLEGVLDRVEGVVRTAMRWNSDDEEKVRRCEWILERIRNTIDGDEELTLILEDPFGNS LIVSDEAFKEIMSKEEAQRLKTGMTIIDITGMSEEELEDLV Archaeoglobus fulgidus NYSGXRC-519e SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||G72276 ICEDB: T807 GENBANK NP_229050.1 KPRACVVVYPGSNCDRDAYHALEINGFEPSYVGLDDKLDDYELIILPGGFSYGDYLRPGAVAAREKIAFEIAKAAE RGKLIMGICNGFQILIEMGLLKGALLQNSSGKFICKWVDLIVENNDTPFTNAFEKGEKIRIPIAHGFGRYVKIDD VNVVLRYVKDVNGSDERIAGVLNESGNVFGLMPHPERAVEELIGGEDGKKVFQSILNYLKR Thermotoga maritima NYSGXRC-537d SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P16384|MIAA_ECOLI ICEDB: T1416 GENBANK NP_418592.1 SDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQ AYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEV DPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFE AEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQ ARDEVLQVVGAIAG Escherichia coli NYSGXRC-544d SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||F69795 ICEDB: T781 GENBANK NP_416590.1 AEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKFGVATVIAGGGDGTINEVSTAL IQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGDAIAIDMAQVNKQTCFINMATGGFGTRITTETP EKLKAALGSVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFT GDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHDITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR Escherichia coli NYSGXRC-626a SGX Pharmaceuticals 2004-04-13 active Selected Cloned Expressed Soluble Purified sp|P51833|RNC_BACSU ICEDB: T1417 GENBANK NP_389475.1 SKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISRFL FAKYPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEP VESFLKVYVFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEPLGVGNGRSK KEAEQHAAQEALAKLQKHHTKQ Bacillus subtilis NYSGXRC-638c SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P09453|RIMI_ECOLI ICEDB: T782 GENBANK NP_290986.1 NTISSLETTDLPAAYHIEQRAHAFPWSEKTFASNQGERYLNFQLTQNGKMAAFAITQVVLDEATLFNIAVDPDYQR QGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNEATIRRNYYPTTDGREDAIIMALPISM Escherichia coli NYSGXRC-641a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P36553|HEM6_ECOLI ICEDB: T828 GENBANK NP_416931.1 KPDAHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAH RPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGADPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLC LPFGEDVYPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDRCFAFMQAVGKGYTDAYLPIVERRKAMAYGE RERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV Escherichia coli NYSGXRC-643a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||D64897 ICEDB: T1595 GENBANK NP_415966.5 QRGCDGCKQNQSREPATIDGFMPKAQESIMGQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVY LSLDPYMRGRMSDEPSYSPPVDIGGVMVGGTVSRVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHPQN PSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGPVGATVGQIGKLKGCRVVGVAGGAEKCRHATEVLGFD VCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNTSARIPVCGLVSSYNATELPPGPDRLPLLMATV LKKRIRLQGFIIAQDYGHRIHEFQREMGQWVKEDKIHYREEITDGLENAPQTFIGLLKGKNFGKVVIRVAGDD Escherichia coli NYSGXRC-652c SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble pir||D72281 GENBANK NP_416984.1 SPVLTQHVSQPITLDEQTQKMKRHLLQDIRRSAYVYRVDCGGCNACEIEIFAAITPVFDAERFGIKVVSSPRHADI LLFTGAVTRAMRMPALRAYESAPDHKICVSYGACGVGGGIFHDLYSVWGGSDTIVPIDVWIPGCPPTPAATIHGF AVALGLLQQKIHAVDYRDPTGVTMQPLWPQIPPSQRIAIEREARRLAGYRQGREICDRLLRHLSDDPTGNRVNTW LRDADDPRLNSIVQQLFRVLRGLHD Escherichia coli NYSGXRC-661a SGX Pharmaceuticals 2002-03-08 active Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data sp|P37128|YFFH_ECOLI ICEDB: T1419 GENBANK NP_416962.1 TQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNTKKKTVVLIRQFRVATWVNGNES GQLIESCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDED IEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQTSHLMD Escherichia coli NYSGXRC-682a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||F72336 ICEDB: T836 GENBANK NP_228577.1 SWYPGHIEKAKRQIKDLLRLVNTVVEVRDARAPFATSAYGVDFSRKETIILLNKVDIADEKTTKKWVEFFKKQGKR VITTHKGEPRKVLLKKLSFDRLARVLIVGVPNTGKSTIINKLKGKRASSVGAQPGITKGIQWFSLENGVKILDTP GILYKNIFSEDLAAKLLLVGSLPVERIEDQRIFERAFEIFARSIGIESSFSEFFEDFARKRGLLKKGGVPDIERA LMLFFTEVAQGKAGRVSFERPEDITPVQQEQTRGV Thermotoga maritima NYSGXRC-687d SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P77392|YBEX_ECOLI GENBANK NP_286383.1 SDDNSHSSDTISNKKGFFSLLLSQLFHGEPKNRDELLALIRDSGQNDLIDEDTRDMLEGVMDIADQRVRDIMIPRS QMITLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILMAKDLLPFMRSDAEAFSMDKVLRQAVVVPESKRVD RMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAF GTHFSDEEVDTIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHVKIPDDSPQPKLDE Escherichia coli NYSGXRC-695c SGX Pharmaceuticals 2005-11-11 active Selected Cloned Expressed Soluble Purified pir||A69273 ICEDB: T1588 GENBANK NP_069024.1 YSDKVFDHFQNPRNVGKIEDADGVGTVGNPVCGDLMTIYIKVKDNRIEDIKFQTFGCAAAIATSSMATEMAKGKTI EEALKITRDAVAEALGGLPKQKMHCSNLAADALRRAIVDYFRKNGKIDKIKELGLEKELEKMEKGEMDDHGEYCE A Archaeoglobus fulgidus NYSGXRC-716g SGX Pharmaceuticals 2000-12-04 active Selected Cloned Expressed Soluble pir||F72319 ICEDB: T605 GENBANK NP_070861.1 EEVLEAAEKIRSMEVRGAARIARFAAETLMKFAEKASDEKFDEEMRFAAETLLNTRPTAVSLYNAINYVMRYSGES VEEKRQSVIRRAREFINWVETAQRKIGEIGEKRIKDGYTVMTHCNSSAALSVIKKAHENGKRVEVIATESRPRWQ GHLTVKQLREAGIEVTLIVDSAVRYFINEVDCVVVGADTITANGALINKIGTSQIALAAKEARVPFMVAAETYKF SPKTLFGELVVIEERDAREVAPEEILKLGVKVRNPAFDVTPRDYIDVIITEIGAIPPEMAYIVITERLGYAGIEE EEITLNSRHFD Archaeoglobus fulgidus NYSGXRC-723a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||D69692 ICEDB: T784 GENBANK NP_389549.1 KTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQIAEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITP LEDKINQIEQLGTEVLYVVKFNEVFASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGC TMVEKLTEQDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNSYIVPPTGVY AVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAIKIEWYKRIRSERKFNGIKELTEQIEK DKQEAIRYFSNLRK Bacillus subtilis NYSGXRC-726a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P77645|YLEA_ECOLI GENBANK NP_308726.1 TKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLI IGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVS IMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAA IDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQI SSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWS RRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAE TPESVIARTRKENDLGVGYYQP Escherichia coli NYSGXRC-729d SGX Pharmaceuticals 2003-11-24 active Selected Cloned Expressed Soluble Purified pir||F69504 ICEDB: T1767 GENBANK NP_070863.1 KVLDFPSSKKAKELAVKYGYDEFIVRRWLHFFGDETEDIIRAFEEGIPKYIRINTLKIDEKGLLERLESRGFKLKK TEVPYCFEVVEEPYSIGATPEYLMGYYYVMDKSSCIPPLALEPKPGEVVVDLAASPGGKTTFLSMLMENKGAVIA VEPQKERLQPLIDNINRMGAMNVAVINVDGRRVPAMGIKADRVLLDAPCTGEGIIHKDPSRKTDRGKEDILFCSS LQRELVLAAFDCLKEGGVMVYSTCSLTPEENEFVVDFLLERRKGVVEEIEWGDEALALPGVKNEVSKARRFYPHR HQCSGFFVARIRKVGDSKAKPE Archaeoglobus fulgidus NYSGXRC-737c SGX Pharmaceuticals 2003-09-09 active Selected Cloned Expressed Soluble Purified pir||F69373 ICEDB: T1590 GENBANK NP_068861.1 PNFFTPEFGPLRGVRVITTGSIIAGPTAGTILADLGAEVIHVERPKVGDTLRVVPPYFEADGKRIGGEFVCVTRNK LSVALDIKSEEGRKIFYELLKHADIFIENLVWLEERYGITDKDMLEANPRLVIVHVSGFGRSEFGGEDEKCGRGS YDIISQAYSGWCKLAAPPGMEVHRLPLYIGDYVTALFGVIGALSAYVYAKETGRGQVVDVAQFEAIARVIEMYYT MYHNLGINREGEGLRVFNTQPYGLYRVKDGWIAIGAIGPGLYQRFIQALAKATGINPADYPYEECAASPEAVNSE KGRELDRIFNEYLMSHTKEEVEKLFNAFRVPCSRVSTPEDVVRDRHWIERGDIIEVLDETTGRLVKQVGIVPKFS ETPGRIWRGPPKLGSDTKKVLKGLLNLSDEQIDELKAKGVVDF Archaeoglobus fulgidus NYSGXRC-740a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P09155|RND_ECOLI ICEDB: T829 GENBANK NP_416318.1 NYQMITTDDALASLCEAVRAFPAIALDTEFVRTRTYYPQLGLIQLFDGEHLALIDPLGITDWSPLKAILRDPSITK FLHAGSEDLEVFLNVFGELPQPLIDTQILAAFCGRPMSWGFASMVEEYSGVTLDKSESRTDWLARPLTERQCEYA AADVWYLLPITAKLMVETEASGWLPAALDECRLMQMRRQEVVAPEDAWRDITNAWQLRTRQLACLQLLADWRLRK ARERDLAVNFVVREEHLWSVARYMPGSLGELDSLGLSGSEIRFHGKTLLALVEKAQTLPEDALPQPMLNLMDMPG YRKAFKAIKSLITDVSETHKISAELLASRRQINQLLNWHWKLKPQNNLPELISGWRGELMAEALHNLLQEYPQ Escherichia coli NYSGXRC-742a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P08204|KIRI_ECOLI ICEDB: T810 GENBANK NP_414605.1 AIAIGLDFGSDSVRALAVDCATGEEIATSVEWYPRWQKGQFCDAPNNQFRHHPRDYIESMEAALKTVLAELSVEQR AAVVGIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEAEEITRLCHAPGNVDYSRYIGGIYS SEWFWAKILHVTRQDSAVAQSAASWIELCDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELD PILNRHLPSPLFTDTWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDILI ADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAQHPELKTQINASQKQLLPA LTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPLLFGGLIAATAFGARAIMECFTDQGIAV NNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPCSE QAQRFEQLYRRYQQWAMSAEQHYLPTSAPAQAAQAVATL Escherichia coli NYSGXRC-753e SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||E69356 ICEDB: T1768 GENBANK NP_069687.1 KVFIDPDGDIEEIKEAFRLINPELYERLLKIDGSDEFFRYMVKPLRVSVRVNTLKAEVDEVVENLKELITGRVPWC EEGFYLSIDEFSRIPEHQLGLIFSQEAASMIPPLVMELEPKMTVLDIAASPGAKTTQIAQYLQNEGCIVANDVKH SRINILISNLQRCGVLIAKVTVKDGRYFGRFRNRFDAVLVDAPCSNMGMIRKNYRNIRLWKMRDCYGLSKLQKSL LMAAYKAVKPGGVVVYSTCTLEPIENEEVVDYILRNTDAEIEEVNLPVKGVEPFTKFDGKEYSEEVRKCLRLHPQ SSDTEGFFVAKLRKP Archaeoglobus fulgidus NYSGXRC-788a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble sp|O29457|RS15_ARCFU GENBANK NP_069635.1 ARIHARRRGKSGSKRIYRDSPPEWVDMSPEEVEKKVLELYNEGYEPSMIGMILRDRYGIPSVKQVTGKKIQKILKE HGVEIKYPEDLKALIKKALKLRAHLEVHRKDKHNRRGLQLIEAKIWRLSSYYKEKGVLPADWKYNPDRLKIEISK Archaeoglobus fulgidus NYSGXRC-799a SGX Pharmaceuticals 2006-10-18 active Selected Cloned Expressed Soluble Purified Crystallized pir||A69496 ICEDB: T1591, T1769 GENBANK NP_070794.1 EIVKEVERLIREGKILDAFELVKQSAPEELRERIEKSFRDAEEIKKLDGIWKKLMLILHFVYASQDAVERQDKQSL VSCVVSSVNAIKLTIELGMKSITPVLMRNAARALILMDMKENAERMYTEAEKICEENRDEEMLAAIENDLATLYY DMGKYNEAKVKAEEALEIRRKIGTKEELAESLATASEIYVKLGDFDEAEECYREAEKLYRELVEEAESFKLNLAI LLSNYAMFRKKLGRYQEAEKMFKEALEIFQNLERIDADFMQFVAAAYRHLGDLYREMKEYSKAEEYYKLSREKFR DIQKRWESVAS Archaeoglobus fulgidus NYSGXRC-827a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||S56390 ICEDB: T1420 GENBANK YP_313069.1 GKTSMIHAIVDQYSHCEWVENSMSANENNLIWIDLEMTGLDPERDRIIEIATLVTDANLNILAEGPTIAVHQSDEQ LALMDDWNVRTHTASGLVERVKASTMGDREAELATLEFLKQWVPAGKSPICGNSIGQDRRFLFKYMPELEAYFHY RYLDVSTLKELARRWKPEILDGFTKQGTHQAMDDIRESVAELAYYREHFIKL Escherichia coli NYSGXRC-830e SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||F64927 ICEDB: T785 GENBANK NP_416209.1 KPVKPPRINGRVPVLSAQEAVNYIPDEATLCVLGAGGGILEATTLITALADKYKQTQTPRNLSIISPTGLGDRADR GISPLAQEGLVKWALCGHWGQSPRISELAEQNKIIAYNYPQGVLTQTLRAAAAHQPGIISDIGIGTFVDPRQQGG KLNEVTKEDLIKLVEFDNKEYLYYKAIAPDIAFIRATTCDSEGYATFEDEVMYLDALVIAQAVHNNGGIVMMQVQ KMVKKATLHPKSVRIPGYLVDIVVVDPDQTQLYGGAPVNRFISGDFTLDDSTKLSLPLNQRKLVARRALFEMRKG AVGNVGVGIADGIGLVAREEGCADDFILTVETGPIGGITSQGIAFGANVNTRAILDMTSQFDFYHGGGLDVCYLS FAEVDQHGNVGVHKFNGKIMGTGGFIDISATSKKIIFCGTLTAGSLKTEITDGKLNIVQEGRVKKFIRELPEITF SGKIALERGLDVRYITERAVFTLKEDGLHLIEIAPGVDLQKDILDKMDFTPVISPELKLMDERLFIDAAMGFVLP EAAH Escherichia coli NYSGXRC-831a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P31434|YICI_ECOLI ICEDB: T822 GENBANK NP_418113.1 KISDGNWLIQPGLNLIHPLQVFEVEQQDNEMVVYAAPRDVRERTWQLDTPLFTLRFFSPQEGIVGVRIEHFQGALN NGPHYPLNILQDVKVTIENTERYAEFKSGNLSARVSKGEFWSLDFLRNGERITGSQVKNNGYVQDTNNQRNYMFE RLDLGVGETVYGLGERFTALVRNGQTVETWNRDGGTSTEQAYKNIPFYMTNRGYGVLVNHPQCVSFEVGSEKVSK VQFSVESEYLEYFVIDGPTPKAVLDRYTRFTGRPALPPAWSFGLWLTTSFTTNYDEATVNSFIDGMAERNLPLHV FHFDCFWMKAFQWCDFEWDPLTFPDPEGMIRRLKAKGLKICVWINPYIGQKSPVFKELQEKGYLLKRPDGSLWQW DKWQPGLAIYDFTNPDACKWYADKLKGLVAMGVDCFKTDFGERIPTDVQWFDGSDPQKMHNHYAYIYNELVWNVL KDTVGEEEAVLFARSASVGAQKFPVHWGGDCYANYESMAESLRGGLSIGLSGFGFWSHDIGGFENTAPAHVYKRW CAFGLLSSHSRLHGSKSYRVPWAYDDESCDVVRFFTQLKCRMMPYLYREAARANARGTPMMRAMMMEFPDDPACD YLDRQYMLGDNVMVAPVFTEAGDVQFYLPEGRWTHLWHNDELDGSRWHKQQHGFLSLPVYVRDNTLLALGNNDQR PDYVWHEGTAFHLFNLQDGHEAVCEVPAADGSVIFTLKAARTGNTITVTGAGEAKNWTLCLRNVVKVNGLQDGSQ AESEQGLVVKPQGNALTITL Escherichia coli NYSGXRC-834a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified dbj|BAA15717.1| ICEDB: T837 GENBANK NP_416410.1 SRLVVVSNRIAPPDEHAASAGGLAVGILGALKAAGGLWFGWSGETGNEDQPLKKVKKGNITWASFNLSEQDLDEYY NQFSNAVLWPAFHYRLDLVQFQRPAWDGYLRVNALLADKLLPLLQDDDIIWIHDYHLLPFAHELRKRGVNNRIGF FLHIPFPTPEIFNALPTYDTLLEQLCDYDLLGFQTENDRLAFLDCLSNLTRVTTRSAKSHTAWGKAFRTEVYPIG IEPKEIAKQAAGPLPPKLAQLKAELKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSRG DVQAYQDIRHQLENEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEYVAAQDP ANPGVLVLSQFAGAANELTSALIVNPYDRDEVAAALDRALTMSLAERISRHAEMLDVIVKNDINHWQECFISDLK QIVPRSAESQQRDKVATFPKLA Escherichia coli NYSGXRC-851e SGX Pharmaceuticals 2006-12-11 active Selected Cloned Expressed Soluble Purified Crystallized pir||F69547 ICEDB: T1592 GENBANK NP_071094.1 QKRVTDEDIKERLDKIGFRIAVMSGKGGVGKSTVTALLAVHYAKQGKKVGILDADFLGPSIPHLFGLEKGKVAVSD EGLEPVLTQRLGIKVMSIQFLLPKRETPVIWRGPLIAGMIREFLGRVAWGELDYLLIDLPPGTGDAPLTVMQDAK PNGAVIVSTPQELTAAVVEKAITMAEQTKTAVLGIVENMAYFECPNCGERTYLFGEGKASELARKYKIEFITEIP IDSDLLKLSDLGRVEEYEPDWFEFFPY Archaeoglobus fulgidus NYSGXRC-891f SGX Pharmaceuticals 2003-09-11 active Selected Cloned Expressed Soluble Purified pir||D72406 ICEDB: T1593 GENBANK NP_069016.1 DRNEMLEFAAKLHSHLSPGVALGIKMAQIAYEKLGVNFRGKGLVGIAETAMCLPDALQVVAGTTPGNRNLIVKDYG KLALAIVRFDTREGYRVTIKKEAAKKSELIKKFLYRLGKLNKEEEKRLAEEFLNLEPEYFEVREIRLTIPVGGTK EPIVECEKCGELQPSDYVAEVDGRMVCFMCAGKGYFE Archaeoglobus fulgidus NYSGXRC-892d SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P32393|CME2_BACSU ICEDB: T670, T812 GENBANK NP_390436.1 ERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYNGSIAGGVHCADEGCLMIDDHCARTIHAEMNAIL QCSKFGVPTDGAEIYVTHYPCIQCCKSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNRE KLSFVAGLIGKLADAGLAEEELKKIHEQANTLFTSYV Bacillus subtilis NYSGXRC-899f SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P09151|LEU1_ECOLI ICEDB: T1421 GENBANK NP_414616.1 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCV EKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLA RVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA LAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT AKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV Escherichia coli NYSGXRC-903a SGX Pharmaceuticals 2006-12-11 active Selected Cloned Expressed Soluble Purified Crystallized sp|O31741|TRMD_BACSU ICEDB: T671, T811 GENBANK NP_389485.1 KIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDNKHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSK AAAAPRIILVCPQGERFTQKKAEQLAKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSV VRLLPGVLGKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYLRRPDLLKDH PLTEQQRKWISEWEKE Bacillus subtilis NYSGXRC-929a SGX Pharmaceuticals 2001-11-15 active Selected Cloned Expressed Soluble Purified Crystallized sp|P04825|AMPN_ECOLI ICEDB: T814 GENBANK NP_415452.1 TQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEE EGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKY PFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAM TSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHN WTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYT LTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKD DYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQ PVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAV LLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAK RTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFIL QATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLI EPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA Escherichia coli NYSGXRC-942a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P46852|YHHW_ECOLI ICEDB: T787 GENBANK NP_417896.1 IYLRKANERGHANHGWLDSWHTFSFANYYDPNFMGFSALRVINDDVIEAGQGFGTHPHKDMEILTYVLEGTVEHQD SMGNKEQVPAGEFQIMSAGTGIRHSEYNPSSTERLHLYQIWIMPEENGITPRYEQRRFDAVQGKQLVLSPDARDG SLKVHQDMELYRWALLKDEQSVHQIAAERRVWIQVVKGNVTINGVKASTSDGLAIWDEQAISIHADSDSEVLLFD LPPV Escherichia coli NYSGXRC-942c SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|P46852|YHHW_ECOLI ICEDB: T1428 GENBANK NP_417577.1 ITTRTARQCGQADYGWLQARYTFSFGHYFDPKLLGYASLRVLNQEVLAPGAAFQPRTYPKVDILNVILDGEAEYRD SEGNHVQASAGEALLLSTQPGVSYSEHNLSKDKPLTRMQLWLDACPQRENPLIQKLALNMGKQQLIASPEGAMGS LQLRQQVWLHHIVLDKGESANFQLHGPRAYLQSIHGKFHALTHHEEKAALTCGDGAFIRDEANITLVADSPLRAL LIDLPV Escherichia coli NYSGXRC-943a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified pir||E69806 ICEDB: T1423 GENBANK NP_313058.1 HGNSEMQKINQTSAMPEKTDVHWSGRFSVAPMLDWTDRHCRYFLRLLSRNTLLYTEMVTTGAIIHGKGDYLAYSEE EHPVALQLGGSDPAALAQCAKLAEARGYDEINLNVGCPSDRVQNGMFGACLMGNAQLVADCVKAMRDVVSIPVTV KTRIGIDDQDSYEFLCDFINTVSGKGECEMFIIHARKAWLSGLSPKENREIPPLDYPRVYQLKRDFPHLTMSING GIKSLEEAKAHLQHMDGVMVGREAYQNPGILAAVDREIFGSSDTDADPVAVVRAMYPYIERELSQGTYLGHITRH MLGLFQGIPGARQWRRYLSENAHKAGADINVLEHALKLVADKR Escherichia coli NYSGXRC-949f SGX Pharmaceuticals 2003-05-21 active Selected Cloned Expressed Soluble Purified pir||E64465 ICEDB: T1434 GENBANK NP_069264.1 QDFKKLPTVLTAEELIDKIFRRAARVEGRNPKEKALNKLATISNVSRDYFGKIIGAHPSYENLPDFYREMVDVVVG IRQLKKSLVALKWADGMIQKVVSRAVREVKGGKNPSAVVKSAYGRVASIIEQIDDELRFLNDAKNRMREIPILQD LPTIVVAGYPNVGKSSLVARISTVKPEVASYPFTTKKINLGFAEFAGKRVQIIDTPGLLDRPLSKRNRIERRAVL ALKHLADIILFVIDPTETCGYSLEKQLSLLEEIKGYFAKPTVEVYSKADMHDRRDRQAYSAVTGEGIDELIKEIE KMVKIHSQTSTVIAPSGQTSTQEQHS Archaeoglobus fulgidus NYSGXRC-970a SGX Pharmaceuticals 2001-09-17 active Selected Cloned Expressed Soluble Purified sp|Q9WYG6|PYRE_THEMA ICEDB: T788 GENBANK NP_228142.1 IKEILEKTGALMEGHFILSSGKHSSRYVQCARLFEFPEYGDVVGEELAKLLKKYDVETVVGPAMGGVILSYVVARY LKARSLFAERENGVMKLRRGFFVKPGEKVAVVEDVVTTGGSVKEVIELLKEYGANVVCVGSIIDRSGGKVDFGVP FESLLKLDLPVYDPEDCPLCKQGIPAEKPGSRGLK Thermotoga maritima NYSGXRC-972a SGX Pharmaceuticals 2003-08-29 active Selected Cloned Expressed Soluble sp|P49999|RECF_STRPY GENBANK NP_387885.1 YIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIYVLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQ NGAIPMQLVISKKGKKGKVNHIEQQKLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSL YQKILSQRNHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGLEELTLKYHT ALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNGRDVQTYGSQGQQRTTALSLKLAEIDL IHEEIGEYPILLLDDVLSELDDYRQSHLLHTIQGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK Bacillus subtilis NYSGXRC-993f SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified pir||F69343 GENBANK NP_069584.1 VRITWCPGCGNFAILKAFERASRRVIEEGFDIAVSSGIGCHGKISDYLSLPGFHVIHGRVPPFLTGLKLANPNLVV VGFSGDGDGLNEGVEHLVHAARRNTDITIILHNNGVFGLTTGQVTATSPRGRKSRSTPRGNPEYPLNPCHLMLVS GATFVARVFAGEQERLSEVFYNAMKHKGFSFVEVMQPCVSFNNFWEMRKEIYWIERSSDLLEAMKNCSDAKACGI FYAEEKETYEDAVWKSTF Archaeoglobus fulgidus NYSGXRC-999a SGX Pharmaceuticals 2001-03-02 active Selected Cloned Expressed Soluble Purified gb|AAC46089.1| ICEDB: T838 GENBANK NP_370678.1 TLNIVITGAKGFVGKNLKADLTSTTDHHIFEVHRQTKEEELESALLKADFVVHLAGVNRPEHDKEFSLGNVSYLDH VLDILTRNTKKPAILLSSSIQATQDNPYGESKLQGEQLLREYAEEYGNTVYIYRWPNLFGKWCKPNYNSVIATFC YKIARNEEIQVNDRNVELTLNYVDDIVAEIKRAIEGTPTIENGVPTVPNVFKVTLGEIVDLLYKFKQSRLDRTLP KLDNLFEKDLYSTYLSYLPSTDFSYPLLMNVDDRGSFTEFIKTPDRGQVSVNISKPGITKGNHWHHTKNEKFLVV SGKGVIRFRHVNDDEIIEYYVSGDKLEVVDIPVGYTHNIENLGDTDMVTIMWVNEMFDPNQPDTYFLEV Staphylococcus aureus NYSGXRC-1012d SGX Pharmaceuticals 2001-04-19 active Selected Cloned Expressed Soluble Purified sp|P54955|YXEP_BACSU ICEDB: T793 GENBANK NP_391826.1 ADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIEILDVPQLKTAVIAEIKGREDGPVIAIRADIDAL PIQEQTNLPFASKVDGTMHACGHDFHTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVS AIFGMHNKPDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHASIPNNSIDPIAAAGQIISGLQSVVSRNISSLQNA VVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIAAGYGAQAEFKWFPYLPSVQNDGTFLN AASEAAARLGYQTVHAEQSPGGEDFALYQEKIPGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLE TIK Bacillus subtilis NYSGXRC-1016d SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble pir||F70933 GENBANK NP_388604.1 KHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGILQPQNALAVLKELGVFEDCCKHGFQTEWFKTFDE QGNLLFQVSESFLDDSLPGRNNILRKTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILA GFDGIHSVVRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVFVLQPCTSDY WDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWHKGRVIIGGDAAHAGAPTLAQGAAMAI EDAIVLAEELQNHADHETALQAYYKRRAPRALKVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY Bacillus subtilis NYSGXRC-1022g SGX Pharmaceuticals 2003-10-14 active Selected Cloned Expressed Soluble pir||F69999 GENBANK NP_147941.2 EALKEVAGEAEGEKSAVITHRNADPDAVGAALVVREVLRALRMNPCLYSPEGISRQSKRLLEAVGEEFGPLCSPDE NPLIAVVVDAANLSQIAGAESLFRAARLKVVIDHHERGSIHEEADVALVDPGAGSSSELAVKTAVEAGTPLRPSV ATAALGGIVYDTGRFLRASKLSFEAAAHLLSMGADYGKVLEAGRQRGRRDRGDLSLRLAKLKAFSRLKIGRACSE LLIAVTHIGSFESDVAKSLVDEAADVAVAVAERTSEFRLSVRVSPLALEKGVTARAIASMLAEKFGGEGGGHDEA GMAHIPYTAAFSAEDMAVKAFNLISGRLGWMCVKTLEKG Aeropyrum pernix NYSGXRC-1029e SGX Pharmaceuticals 2003-09-11 active Selected Cloned Expressed Soluble Purified pir||F71002 ICEDB: T1508, T2189 GENBANK NP_070061.1 IDLHIHSNYSDGQGSVEEIARRAKERGLKAIAIVDHSIELPFGLTEKKARMREIEIENAASLYGIKIYSGIECSIN AAGEIVLPDFDFDFIIASVHEFVYGQAYYERVIRCLESHDVDVLGHPFSPLFGFDGRLAEMDEKLLDVVEERGVA VELNSSHKSPQDEFLQLCRDRKIAYSIGSDAHSLSGVGEVGWSVEKAKRYMAGAKLFTP Archaeoglobus fulgidus NYSGXRC-1036h SGX Pharmaceuticals 2003-03-27 active Selected Cloned Expressed Soluble Purified pir||C75607 ICEDB: T1400 GENBANK NP_285444.1 APLISVLDLTPVSTGQQPGEALRHTLELAEVADSYQYTRFWIAEHHNSGAFVSAATEILIALAAARTGRIRVGSGG VMLPNHSPLKVAENFMSLEALFPGRIDLGLGRAPGTDGRTALALRRSREALAADDFPTQIALLRAFAGETPWPAG SVFDGVLAEPRGVKLPPLWILGSSLYGAQLAGELGVGYAFAYHFSQEDPAVAVQTYHRHFRPGPLAEPYAILGVN ALAAPTEDEARDLSLTSAALSLGILSGQRGVLRSPEEARQWLQEMDTDPAKLLKKARIGTPEQVWASLQELGEST GAQEMLVTTYAHDPLKRQQSYRLLAQAAGMTPQKEA Deinococcus radiodurans NYSGXRC-1040a SGX Pharmaceuticals 2003-09-24 active Selected Cloned Expressed Soluble pir||E70552 GENBANK NP_388891.1 KVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDTVFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQE GRPLFENRFKNRAGKVENEPGFEAIRVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSI FSRPSYVTTYFAVE Bacillus subtilis NYSGXRC-1040b SGX Pharmaceuticals 2001-10-01 active Selected Cloned Expressed Soluble Purified pir||E70552 ICEDB: T790 GENBANK NP_293995.1 ITVANRIFVNPERAAAFEERFRRRPRRVDRQPGFIADHVLRPTQAGDPYVVLSFWDSRAAFEAWRTSPGFKDGHKG GRTLPEDTVLSNVIEIHEVFTGSDDAGTGEES Deinococcus radiodurans NYSGXRC-1040c SGX Pharmaceuticals 2001-10-23 active Selected Cloned Expressed Soluble Purified pir||E70552 ICEDB: T1425 GENBANK NP_294169.1 ITVMNRIGVKPEFAAQFEESFRNRAGLVDGMPGFIRNEVLKPTKPGDPYIVLTYWQDEPSFRAWTESDEFKQGHAR SGSLPHDAFTGRPVLEVHDVLLSSDN Deinococcus radiodurans NYSGXRC-1042g SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified sp|P39841|MANA_BACSU ICEDB: T1509 GENBANK NP_068876.1 ELPSFIFQAQENLVERPWGGEWIALLKGFRQSGIGESWEFSAHTSRPSTVLVKGQQLSMIELFSKHRDELLGRAAE KFSKFPILVRLIDAASPTQVHVHPSDKAAESLGEAEGGVESAWLVFNKGKAYAGFKEDVKIEELEEKLKEEDFDF KTLLNTFETTPYDTFVIRPGIPHAGEGLRVLEVSSNSTLAYFFNENDWEKVKKVLNTKKVEEFEVKGKKGMAETE NFGLEVVDVTGTAEIKTGGVMNILYAAEGYFILRGKETADLHRGYSCLVPASTDSFTVESERGKIVRIYLKV Archaeoglobus fulgidus NYSGXRC-1046h SGX Pharmaceuticals 2003-09-15 active Selected Cloned Expressed Soluble Purified emb|CAB75241.1| ICEDB: T763 GENBANK NP_281788.1 QKLVENLALKYYDKVVDLRHQIHMHPELEFEEENTAHLVCKILDEFGIKYQKNIAKTGILAIIEGKKKSQKKPKCV LLRADMDALPVQEKTNLSYASKIDGKMHACGHDGHTAGLLGAALILNELKDEFCGTIKFMFQPAEEGSGGAKPMI ESGVLENPYVDAVFGCHLWGPLLENTAQIVSGEMMAGTDIFDLEFIGRGGHGAHPHTCIDPIIMTTQFVNNIQSV ISRRLAPYEAGVITVGQICAGTTYNVIPTNAYLKGTVRFLNDKTQDILKSSLEEVAAATAKSNGGDYKLKYTKEF PPLINDEKAVLIARKAFAKVLGEENIIVSSKPDMGAEDFAFLTRERMGAYVFVGISKDLNHPALHHSSTFCWDDE NLKVLMQGDVMMALEFLN Campylobacter jejuni NYSGXRC-1048a SGX Pharmaceuticals 2001-04-06 active Selected Cloned Expressed Soluble Purified gb|AAF73820.1| ICEDB: T830 GENBANK NP_252160.1 TDNLLSISAACLFDDQGNLLLVRKRGTQAFMLPGGKREPGETPLAALQRELLEELRLPMGASTFEHLGSFQAPAAN EANTRVDADIYVARLPHAVCAQAELEELAWLVPGQAQPDNLAPLLRDHVLPALARRAAENPETQAEHRTRPDHV Pseudomonas aeruginosa NYSGXRC-1051e SGX Pharmaceuticals 2004-12-10 active Selected Cloned Expressed Soluble Purified sp|P44321|3MGA_HAEIN ICEDB: T797 GENBANK NP_231308.1 MNAEQGVCAWAMNHPLEREYHDKEWGRAVHDDTKLFEFLTLEGAQAGLSWLTVLKKREGYRQAFLGYDLQRLAQCD ESHVEQIIAEYDVVKHRGKIASVFSNARAALALQQEFGSLDAALWQFVGGQPKINRWVSMSDVPASTEESKAMSK FLKKRGFKFVGETICYAFMQACGLVNDHLVGCPNHSNADKL Vibrio cholerae NYSGXRC-1057c SGX Pharmaceuticals 2003-10-15 active Selected Cloned Expressed Soluble Purified gb|AAB51062.1| ICEDB: T1557, T521 GENBANK NP_388351.1 DFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPPEEIISIHRKVLKELYPSLPEDVFHSLDFLIEVM IGYGMAYQEHQTLRGIQQEIKSEIEIAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAI ADVIGKGIPAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQFTYASAGHEP GFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGVTECRTENGFLERPDLQKLIEEHMCSS AQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRKV Bacillus subtilis NYSGXRC-1060f SGX Pharmaceuticals 2001-05-07 active Selected Cloned Expressed Soluble Purified gb|AAF72890.1|AF227983_5 ICEDB: T1401 GENBANK YP_001337275.1 VLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPELARSLADRNISAAVSIDVRNMPESPEIFEQAMKNLPAE FSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDEESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRL LGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLE LWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKS Klebsiella pneumoniae NYSGXRC-1066h SGX Pharmaceuticals 2001-10-24 active Selected Cloned Expressed Soluble Purified emb|CAA66626.1| ICEDB: T1402 GENBANK NP_294585.1 TSALPRPAPSPYARRKTALVIGAGFGGLALGIRLQSLGFDTTILERLDGPGGRAYQKRTPDGYVFDMGPTVLTVPH FIEELFALERDRAGLDAPDYPPEVLSGERVKEGVSGGPHTSRYVTLVPILPFYRIVFHDGTYFDYDGDPESTRRQ IAELAPGDLAGYERFHADAEAIFRRGFLELGYTHFGDVPTMLRVVPDLLKLDAVRTLFSFTSKYFQSDKLRQVFS FETLLVGGNPLSVPAIYAMIHFVEKTWGIHYAMGGTGALVRGLVQKFEELGGAIRYGAGVDEVLVDGNLPGKRTA RGVRLESGEELRADLVASNGDWANTYLKRVRPSARLVNSDLRVKAASESMSLLVVYFGFRGGDDLPLKHHNILLG PRYEALLSEIFGTKRLGEDFSQYLHVPTLTDPALAPAGHHAAYTLVPVPHNGSGIDWDVEGPKLAEAALADIERR GLIPGLRERLTHFEFITPDYFAGTLDSYLGNAFGPEPRLVQSAFFRPHNRSEDLHNFYLVGAGAQPGAGTPSVMM SAKMTARLIAEDFGIHADIR Deinococcus radiodurans NYSGXRC-1069b SGX Pharmaceuticals 2003-09-11 active Selected Cloned Expressed Soluble Purified gb|AAC44803.1| GENBANK NP_388874.1 AKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSGDIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYR GRTQLKLRNIRPVSEQENVNIDDFLETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKN HHEFVSGLAYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGHISIMVTELS KAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNLDAKMNMMDRALERVKPGEYTERVFAL ENRSFYKPTFHK Bacillus subtilis NYSGXRC-1082b SGX Pharmaceuticals 2001-05-09 active Selected Cloned Expressed Soluble Purified emb|CAA96184.1| ICEDB: T796 GENBANK NP_346586.1 RQLAKDINAFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVK EGMLETSKDSKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEIK Streptococcus pneumoniae NYSGXRC-1088c SGX Pharmaceuticals 2001-11-14 active Selected Cloned Expressed Soluble Purified gb|AAD50303.1| ICEDB: T1403 GENBANK ZP_01678847.1 PDVRKAMSHPIEQLEQIMRRLRDPEQGCPWDKEQTFDTIAPYTIEETFEVVDAITQRDWPNLREELGDLLFQVIFY SQMAKEQGLFEFRDVVETVNEKLTRRHPHVFGDATFENDAQIHANWEAEKAKEKAQAGKSEQSILDSVPRSLPAL SRAYKIQKKCAQYGFDWDSLGPVVEKVHEEVEEVMEEALQVDVDTQKVEEELGDLLFATVNLVRHLGHDPEMALS KANAKFVRRFQGVEDKARAKNKPLHAFTLAELDGFWDEVKLEEKQAIKSFS Vibrio cholerae NYSGXRC-1088d SGX Pharmaceuticals 2001-04-19 active Selected Cloned Expressed Soluble Purified gb|AAD50303.1| ICEDB: T1404 GENBANK NP_289335.1 NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEG RFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRC ANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRF REVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL Escherichia coli NYSGXRC-1158a SGX Pharmaceuticals 2003-10-15 active Selected Cloned Expressed Soluble Purified pir||E69994 ICEDB: T1558 GENBANK NP_390941.1 YEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHEDRGYEFPGGKVEPMECAEEAALREVKEETGARV KSLKYLGQYKVLGKEKVIVKNIYFADIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLK ESGWIE Bacillus subtilis NYSGXRC-1171g SGX Pharmaceuticals 2003-09-17 active Selected Cloned Expressed Soluble pir||G69420 GENBANK NP_070197.1 HEYELNQDLLAENKRLAEKNREALRESGTVAVNIMGAIGSGKTLLIERTIERIGNEVKIGAMLGDVVSKADYERVR RFGIKAEAISTGKECHLDAHMIYHRLKKFSDCDLLLIENVGNLICPVDFDLGENYRVVMVSVTEGDDVVEKHPEI FRVADLIVINKVALAEAVGADVEKMKADAKLINPRAKIIEMDLKTGKGFEEWIDFLRGILNVHSDSGQN Archaeoglobus fulgidus NYSGXRC-1200a SGX Pharmaceuticals 2001-09-04 active Selected Cloned Expressed Soluble Purified pir||F72369 ICEDB: T816 GENBANK NP_388997.1 EEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHITMTLTSMGCPLAPIIVDEVKKALADLPEVKDTE VHIVWNPPWTRDKMSRYAKIALGIQ Bacillus subtilis NYSGXRC-1200b SGX Pharmaceuticals 2001-06-12 active Selected Cloned Expressed Soluble Purified pir||F72369 ICEDB: T1426 GENBANK NP_345547.1 AYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDGDTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEV PEVTDTEVKLVWYPAWTVEKMSRYARIALGIK Streptococcus pneumoniae NYSGXRC-1200d SGX Pharmaceuticals 2001-10-25 active Selected Cloned Expressed Soluble Purified pir||F72369 ICEDB: T1432 GENBANK NP_228297.1 PMSKKVTKEDVLNALKNVIDFELGLDVVSLGLVYDIQIDDQNNVKVLMTMTTPMCPLAGMILSDAEEAIKKIEGVN NVEVELTFDPPWTPERMSPELREKFGV Thermotoga maritima NYSGXRC-1202b SGX Pharmaceuticals 2001-05-07 active Selected Cloned Expressed Soluble Purified sp|O34790|PCRB_BACSU ICEDB: T818 GENBANK NP_388542.1 YDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVTEDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFD LYFIPSVLNSKNADWIVGMHQKAMKEYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELL QLPIFYLEYSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRALKTVAAVKG E Bacillus subtilis NYSGXRC-1205c SGX Pharmaceuticals 2003-09-24 active Selected Cloned Expressed Soluble emb|CAB82458.1| GENBANK NP_391264.1 KTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEK VFEKGVRKDLYDVEQDYYQTFISLFAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWL HYYDWLSRLIEFFESEEVFRYVPKTKECSSLK Bacillus subtilis NYSGXRC-1219a SGX Pharmaceuticals 2001-10-30 active Selected Cloned Expressed Soluble Purified pir||E70885 ICEDB: T1405 GENBANK NP_217375.1 DLSASRSDGGDPLRPASPRLRSPVSDGGDPLRPASPRLRSPVSDGGDPLRPASPRLRSPLGASRPVVGLTAYLEQV RTGVWDIPAGYLPADYFEGITMAGGVAVLLPPQPVDPESVGCVLDSLHALVITGGYDLDPAAYGQEPHPATDHPR PGRDAWEFALLRGALQRGMPVLGICRGTQVLNVALGGTLHQHLPDILGHSGHRAGNGVFTRLPVHTASGTRLAEL IGESADVPCYHHQAIDQVGEGLVVSAVDVDGVIEALELPGDTFVLAVQWHPEKSLDDLRLFKALVDAASGYAGRQ SQAEPR Mycobacterium tuberculosis NYSGXRC-1235h SGX Pharmaceuticals 2003-04-29 active Selected Cloned Expressed Soluble Purified pir||F72388 ICEDB: T1443 GENBANK NP_228155.1 KISVLGAGCIGGSIALKLKEKHHVTAFDRDEETMKALEENGIETVSKESDLYDTDLLVLALPMSVEERFLKETDFS GKILDVASVKTPFMEIARERGLNFTGGHPMAGNERKGKSGWDREMFDGKIFFLCSLDGKEDGMIENIVKDLGARP LWIDYRIHDEIVAAVSHVQYLISLSARYVGKPFEEYAGPGYLSNTRLSKQNMEMALDMIRYNKENILKYLENARN FLNVLYHLTEKEDFENLKKVIREVIS Thermotoga maritima NYSGXRC-1254h SGX Pharmaceuticals 2003-02-21 active Selected Cloned Expressed Soluble Purified gb|AAF94512.1| ICEDB: T1449 GENBANK NP_295557.1 TVLPVPDLLARALDRRAGLPGAGTTFFRAVHITETGGLWTLDVAGDAGILSLYTDLSAEAERDLAAQCGEAAGLSS VYLKRRPPEAKHLANVAREVLSPPDPLWGTARPEVTALEEGVPFLIRPGADLSVGLFSDARPARRWVRGHAAGQR VLNTFAYTCGFGLNAALAGAASVKNVDLSRKVLGWGQQNYALSGLAAPDHDFLYGDVFEWLTRLQRRGDLFDLVI LDPPGFARSKAGTWRAEKDYGRLMAQASAVTAPGGEVLALLNHAGVSAGGLTHMVEQGLSTAGRRGHLTETLGPG RDYPGATHLKVQRWSLN Deinococcus radiodurans NYSGXRC-1266g SGX Pharmaceuticals 2003-04-25 active Selected Cloned Expressed Soluble Purified pir||H72311 ICEDB: T1441 GENBANK NP_228771.1 RWEEVEPVVRELLDFQISSPEEFRTFINKVTDFFDRVREEHGWLYIKMTVNADKEEFAKAYEEFQKEIVAKLKPYE QKIKEKIVENEHFAPRGYEHMIKVIKNDVELFREENVPLQVKESILSRNYGTIVGNIEVDFEGEKKTLQQLSVYL RDPDRSTRELAWRKRYEGIWEVRDKLNKLFDELKEIRHQQALNAGFSNYRDYMHRLKSRFEYTPEDLYRFHEAVE KEVVPYLVERTKIRQRKLGIESVRPWDTAVDVDGKVLKPFSSVEEFMEKTERALKRLNPTFAERFRLMREKNLLD LENRKGKAPGGYNHTLPKTGAPFIFMNAVGQPGDVRTIFHELGHSMHSFETLSLPVFYRPHRMEVAELASMSLEL ISMEYWDEFYTDPEDLKKAKIEELEGALYFLPWCMIVDAFQHWIYTNPDHTPKERDEYFAYLMDRFNPGVDWSDL DEEKKTRWLFQLHIFEVPFYYIEYGIAQIGALAIYRNYIEDPEKTLKDYQRFLSVGCSMPVDEVYKTAGIELKFS RDYIREIVDFVAKQIEEIEK Thermotoga maritima NYSGXRC-1272c SGX Pharmaceuticals 2003-04-29 active Selected Cloned Expressed Soluble Purified sp|P07656|PHOU_ECOLI ICEDB: T1459 GENBANK NP_229065.1 VDHVHFERELTLLKSDVSKMLFLVSESLNDAIESLETMNETLARKVLESDDMIDELNREIEEKAYQIIARYNPILK QLRYIITILKFSNDLERIGDLSCNIAEKCLFLSEEKIKFEMLKELKDMFGSTLKVVQDAFKAFVEEDVDLAFRLW KFDDVIDEMEKKIRRIVVERIREGNISAELALVYILIARDLERVGDHANNLCEEVIYIETGKNMKEFLRGVESGS EGADS Thermotoga maritima NYSGXRC-1275b SGX Pharmaceuticals 2003-04-29 active Selected Cloned Expressed Soluble Purified sp|P32673|PTWB_ECOLI ICEDB: T1448 GENBANK NP_290587.1 TKIIAVTACPSGVAHTYMAAEALESAAKAKGWEVKVETQGSIGLENELTAEDVASADMVILTKDIGIKFEERFAGK TIVRVNISDAVKRADAIMSKIEAHLAQTA Escherichia coli NYSGXRC-1279c SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble Purified pir||S47672 GENBANK NP_231189.1 NKVWLTGLLTATASGVFSASTLAATEITWWHAMGGQLGETVNQLATDFNASQSDYKLTPVYKGSYTETLTAGIAAF RAGQAPNILQVFDAGAATIMSSKGVAKPVQDLMIESGYPFTAQDYIAGVRNFYADNTGKMVGMPFNSSTPVLYYN KDMLASVNAQAPQTYEQLEQVAAKLAEKGQAGFAQSLTPWIMFENFKSRHNLPLSDKQNGYQDLSTKIMFNSDDM LMHVKKLKEWSDKGYYKYYGSDWDANQTPFERGEVAMWMGSSGSFGGLRNRVKFNLGTTYLPYWESVTKNPTHTF IGGAALFALQGHTPAQDKGVAAFFAYLTKPETQMNWHKTTGYVPVTNAAYDLTKQSGYYQENPDAEVGVKQLSLP DGEWTKGYRLGYYPQVREVMHREFDNIFSGRSTVESSLNKVEDESAKLLNRFARTVQ Vibrio cholerae NYSGXRC-1279d SGX Pharmaceuticals 2005-11-10 active Selected Cloned Expressed Soluble Purified pir||S47672 ICEDB: T1559 GENBANK NP_233416.1 TNKWIGALGLLLSGQLMASELVIESWRADDKALWEQKIIPAFEAANPGIKVKFNPVPNVNYTPTLWENLKAGKAGD LITCRPFDDSLALFKAGHLAEITEMAGMENFPSFAQAPWQTDSGAQTFCVPMASVIHGFFYNKKIFNELGLSVPQ TREQFFTVLDKVKADGRYIPLSMSGSESWVASELGYQNIGPNYWKGEDGRLALINGQEHLDDSQYVKVFEELARW RAYLGEDGELRDYGTSNELFTSGKAALYVAGSWEIAPFTDKVDFGVMRPPVAKQGDGCFFTDHTDIGMGMNPASK NPQAAMAFLQWLTTPEFAELYTNSLPGFFSLSNHFFDVTNPAAREMMEWRDQCDSTIRVATQILSRGQPKLGDEL AEVSQAVLVGKMTPTAAAERLEQGLKRWYAPHQTRKAKEQECQCVEPISPTTRLNTLPVVDIAPVVASDPVPPTE ATILSE Vibrio cholerae NYSGXRC-1279f SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified pir||S47672 ICEDB: T1796 GENBANK NP_289998.1 AQAVTTIPFWHSMEGELGKEVDSLAQRFNAENPDYKIVPTYKGNYEQNLSAGIAAFRTGNAPAILQVYEVGTATMM ASKAIKPVYDVFKEAGIQFDESQFVPTVSGYYSDSKTGHLLSQPFNSSTPVLYYNKDAFKKAGLDPEQPPKTWQD LADYAAKLKASGMKCGYASGWQGWIQLENFSAWNGLPFASKNNGFDGTDAVLEFNKPEQVKHIAMLEEMNKKGDF SYVGRKDESTEKFYNGDCAMTTASSGSLANIREYAKFNYGVGMMPYDADAKDAPQNAIIGGASLWVMQGKDKETY TGVAKFLDFLAKPENAAEWHQKTGYLPITKAAYDLTREQGFYEKNPGADTATRQMLNKPPLPFTKGLRLGNMPQI RVIVDEELESVWTGKKTPQQALDTAVERGNQLLRRFEKSTKS Escherichia coli NYSGXRC-1286g SGX Pharmaceuticals 2003-05-13 active Selected Cloned Expressed Soluble Purified gb|AAF94522.1| ICEDB: T1438 GENBANK NP_229792.1 TTSAHKHPYKIVASDLDGTLLAPNHQLSEFSKQTLKQLHDKGFTFIFATGRHHIDVAGIREIAGIPAYMITSNGAR VHDQNDQLMYSKNVPQDLVQAIIDVVKHDKQLFVHLYRNDEWMLNKEDEILRDFHEDSGFTYRVFDVNNAPTDGI AKIFFTQEDQDHEHLVQYETLLNQRFGDKLNVAFSTPWCLEVMCAGVSKGDALQAVAESLHLGLENCIAFGDGMN DVEMLSMAGKGLVMGTAHEKVFNALPDNEVIGSNADDAVAHYLHQHLF Vibrio cholerae NYSGXRC-1311a SGX Pharmaceuticals 2001-10-23 active Selected Cloned Expressed Soluble Purified gb|AAG04379.1|AE004532_3 ICEDB: T794 GENBANK ZP_01823186.1 KPSDFVKYLQRMIALTDTGLTFTKDPFDRERYEDLRSLLSEMLNQGSDLDAEEVAEVLKPTSAYATPLMDVRAWIV EDEKICLVRGQGEGSWALPGGFGEVGYSPTENILKEIEEETGFKAKVERLLAVFDINRFQLQSKQYAKFVFECKL LDGQFQENQEIADLQFFAIDQLPVLSEKRITKEQIEILWQVYQGQREQYLD Streptococcus pneumoniae NYSGXRC-1314f SGX Pharmaceuticals 2004-12-12 active Selected Cloned Expressed Soluble Purified pir||D82291 ICEDB: T1433 GENBANK NP_230355.1 KINITGKNIEVTSAIRNHIEGKLKKLEKWQVDIIGCQASFSEEPNKQKKFEAVVSIPRGQLVASAIHEDLYAAINE VEQKLERQLNKLRHKPEARRADKTELSEEVE Vibrio cholerae NYSGXRC-1323f SGX Pharmaceuticals 2001-03-13 active Selected Cloned Expressed Soluble Purified gb|AAF95295.1| ICEDB: T1406 GENBANK NP_438277.1 ITVYGIKNCDTVKKALKWLADHNIEHKLHDYRVDGLDLNFLTQAETQFGWDVLVNKRSTTWRNLDEQVKNSLDKTT ALSVLAENPTLIKRPIILQDGKALIGFNEKEYQAAFA Haemophilus influenzae NYSGXRC-1341g SGX Pharmaceuticals 2003-09-26 active Selected Cloned Expressed Soluble Purified sp|P37347|YECD_ECOLI ICEDB: T2195 GENBANK AP_002487.1 RHDFVFSGVIMLELNAKTTALVVIDLQEGILPFAGGPHTADEVVNRAGKLAAKFRASGQPVFLVRVGWSADYAEAL KQPVDAPSPAKVLPENWWQHPAALGATDSDIEIIKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARN AWELGFNLVIAEDACSAASAEQHNNSINHIYPRIARVRSVEEILNAL Escherichia coli NYSGXRC-2686a SGX Pharmaceuticals 2003-09-03 active Selected Cloned Expressed Soluble sp|Q46868|YQIC_ECOLI GENBANK NP_708853.1 TYPYRTTMALNTYQYRETTMIDPKKIEQIARQVHESMPKGIREFGEDVEKKIRQTLQAQLTRLDLVSREEFDVQTQ VLLRTREKLALLEQRISELENRSTEIKKQPDPETLPPTL Escherichia coli NYSGXRC-2689d SGX Pharmaceuticals 2004-04-08 active Selected Cloned Expressed Soluble Purified sp|P43991|Y389_HAEIN ICEDB: T1542 GENBANK NP_231621.1 RSYLGSISTSKTEVNSMKMHVLKLLIPTMALLLSACASLPPELGNPDDKSVVTQYSAWLERDPATQSPVRMGGVVA NISNQKDRTRVELVNLPIDSAGRPNIHQEPQGRFVAYVPGFLDPITYGEGRLLTLYGTTAPSEQGKVGDYEHTYP VMNAQGYHLWRVEERVEVDDIGPYMFPCRGFYCWPRTMPERDGKIIQEVK Vibrio cholerae NYSGXRC-2689e SGX Pharmaceuticals 2003-07-16 active Selected Cloned Expressed Soluble sp|P43991|Y389_HAEIN GENBANK NP_438550.1 KGKITLFFTALCFGLTGCIAPPKGLEKERFSINSYREISPQDLTCHCKTVRLGGKIVNTTVLANQTKIEVLSLPVS SISAKPFVELQSDGRFIVYFNGFVEPENLKERYITVGGQLAGTEKGKIEQADYTYPVVQADKYRIWTLSTTYDYP TDDWDEDDDWGFFRWRHRLWYVQPEIHYYLN Haemophilus influenzae NYSGXRC-2691c SGX Pharmaceuticals 2003-07-09 active Selected Cloned Expressed Soluble gb|AAG07217.1|AE004800_6 GENBANK NP_249920.1 SREPQTYLAQRFDPDALGQPALALQLEARHNDTEVPVHRHRKGQLVVACRGGITCTVPDGLWMVPAGFGVWIPGGI AHSNRVTANGKVCFLFVEPGAARLPSDCCTLALSPLVLELILHLSAQPQDYPHDGPLARLAGVLLELLEQAPTEQ LYLPLPDNRGLRRIADELTRAPGDRASMAEWARRVAMSERSLARMVRRETGMTFGQWRQQLQIIIALQQLSAGVS VQRTAEILGYESVSSFIGMFRKALGSPPARYVRDSM Pseudomonas aeruginosa NYSGXRC-2694a SGX Pharmaceuticals 2004-12-08 active Selected Cloned Expressed Soluble Purified gb|AAG05421.1|AE004629_10 ICEDB: T1560 GENBANK NP_417541.1 NNTPRYPQRVRNDLRFRELTVLRVERISAGFQRIVLGGEALDGFTSRGFDDHSKLFFPQPDAHFVPPTVTEEGIVW PEGPRPPSRDYTPLYDELRHELAIDFFIHDGGVASGWAMQAQPGDKLTVAGPRGSLVVPEDYAYQLYVCDESGMP ALRRRLETLSKLAVKPQVSALVSVRDNACQDYLAHLDGFNIEWLAHDEQAVDARLAQMQIPADDYFIWITGEGKV VKNLSRRFEAEQYDPQRVRAAAYWHAK Escherichia coli NYSGXRC-2694c SGX Pharmaceuticals 2003-10-03 active Selected Cloned Expressed Soluble Purified gb|AAG05421.1|AE004629_10 ICEDB: T1561, T1772 GENBANK NP_231841.1 SNEVERVYPRLLDFVRKKYVSKNLLRVTLTGEDLIGFPEDQNGSHIKVFFPNQASGILQLPIREGDKVIWPEHKPV PRAYTVRQYRAQSNELDIDFVVHGEGTPGGGWALKAQTGSQLGLIGPGGPDPLIEPADWHIMAGDLSAVPAISAI LEKMPSQAKGYVFLEVDDIEDKHDISHPEQMVIKWLVRDPNQAQPVLAMAIEQLPVPQGAESLSAFVAGENESVI ACRKILRNEYRIARDKIYAIPYWKRGKNEEAYHEERHVVMDEEF Vibrio cholerae NYSGXRC-2698c SGX Pharmaceuticals 2003-09-08 active Selected Cloned Expressed Soluble Purified sp|P44583|YHCH_HAEIN ICEDB: T1562 GENBANK NP_417688.1 MMGEVQSLPSAGLHPALQDALTLALAARPQEKAPGRYELQGDNIFMNVMTFNTQSPVEKKAELHEQYIDIQLLLNG EERILFGMAGTARQCEEFHHEDDYQLCSTIDNEQAIILKPGMFAVFMPGEPHKPGCVVGEPGEIKKVVVKVKADL MA Escherichia coli NYSGXRC-2698d SGX Pharmaceuticals 2003-07-18 active Selected Cloned Expressed Soluble Purified sp|P44583|YHCH_HAEIN ICEDB: T1570 GENBANK NP_438399.1 IISSLTNPNFKVGLPKVIAEVCDYLNTLDLNALENGRHDINDQIYMNVMEPETAEPSSKKAELHHEYLDVQVLIRG TENIEVGATYPNLSKYEDYNEADDYQLCADIDDKFTVTMKPKMFAVFYPYEPHKPCCVVNGKTEKIKKLVVKVPV KLI Haemophilus influenzae NYSGXRC-2699c SGX Pharmaceuticals 2003-09-29 active Selected Cloned Expressed Soluble sp|P43660|LPFA_SALTY GENBANK NP_462541.1 EFLMKKVVFALSALAVVSTSAFAAESGDGTIKFTGEIVDAPCVVSTDSQNQEVVLGQVKKNIFKAIGDKSSSKPFQ IKLEDCDITSNTKVNVSFNGVGDTDDATLVSVNTEAGAATGVGIGIYDNANKLVEMNTGKSTTTLAAGQTVLYYT ANYVATKDTVTTGYGNAEVDFNLSYE Salmonella typhimurium NYSGXRC-2701d SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble Purified sp|P44882|YGFB_HAEIN GENBANK NP_232105.1 LSGGLSLNDKSWQALVFDYTNDGMGWPIGALASAEQILLAMSAQLVDTDFELSLLLPEGEGEEALFELADAVAEWI NHFISGLGLSGANLKHASVEAKEALEDLEEMSKLGIDEEDDLAEQAELLEQVIEHIKACVLVLHAEFGVKPEQDT KPTVH Vibrio cholerae NYSGXRC-2702e SGX Pharmaceuticals 2003-05-21 active Selected Cloned Expressed Soluble gb|AAG06868.1|AE004769_1 GENBANK NP_147155.2 GALILSDRDIRALLAIGDLVVEPLSGDTVRENGLDLRLGRGFCRFKRSDRVLDPRAPGSPGEFYECGEGDEIIVGP GEHMLLHTQEYIRLPGYVAGLVNLRSTWARTGIYIPATVVDAGFEGQLTIEVVGSGFPVKLYPGDRFLHLVLVKL QSPAMNPYRGRYQGQRGVRLPKLFAKNTG Aeropyrum pernix NYSGXRC-2703d SGX Pharmaceuticals 2003-07-11 active Selected Cloned Expressed Soluble Purified gb|AAG07141.1|AE004794_6 ICEDB: T1564 GENBANK NP_252443.1 NCTLDELRQRIEAHRPRQLDTDQRFPQAAVLVPITRSDDPELVLTLRAAGLSTHGGEVAFPGGRRDPEDADLVRTA LREAEEEIALPPGLVEVVGPLSTLVSRHGIEVTPYVAFIPDFVEYQPNDGEIAAVFNVPLSFFRDDPREVTHRID YFGRSWYVPSYRFGEFKIWGLTAIMVVELVNLLYDDPIDLHTPPASFIKLS Pseudomonas aeruginosa NYSGXRC-2706a SGX Pharmaceuticals 2003-11-18 active Selected Cloned Expressed Soluble Purified gb|AAG08020.1|AE004877_7 GENBANK AAA69103.1 LACCAIYSPVRCAFPYTETERRFTCKRRIFRIILTLCGRENMKIRALLVAMSVATVLTGCQNMDSNGLLSSGAEAF QAYSLSDAQVKTLSDQACQEMDSKATIAPANSEYAKRLTTIANALGNNINGQPVNYKVYMAKDVNAFAMANGCIR VYSGLMDMMTDNEVEAVIGHEMGHVALGHVKKGMQVALGTNAVRVAAASAGGIVGSLSQSQLGNLGEKLVNSQFS QRQEAEADDYSYDLLRQRGISPAGLATSFEKLAKLEEGRQSSMFDDHPASAERAQHIRDRMSADGIK Escherichia coli NYSGXRC-2708a SGX Pharmaceuticals 2003-11-24 active Selected Cloned Expressed Soluble Purified gb|AAG06359.1|AE004723_3 ICEDB: T1773 GENBANK NP_287222.1 QKVKLPLTLDPVRTAQKRLDYQGIYTPDQVERVAESVVSVDSDVECSMSFAIDNQRLAVLNGDAKVTVTLECQRCG KPFTHQVYTTYCFSPVRSDEQAEALPEAYEPIEVNEFGEIDLLAMVEDEIILALPVVPVHDSEHCEVSEADMVFG ELPEEAQKPNPFAVLASLKRK Escherichia coli NYSGXRC-2710g SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified sp|P44679|YBGC_HAEIN ICEDB: T1510 GENBANK NP_282117.1 KMRVYYEDTDAGGVVYHSNYLKFCERARSEIFFNKKVDIFDASKGHFLLAKANCNFLKPAKLGDMIEIKTKILEVK NASVEILQEIYKDEILLFKMELTLAFIKNEKPARMDMQLKKLFEELF Campylobacter jejuni NYSGXRC-2710h SGX Pharmaceuticals 2001-03-12 active Selected Cloned Expressed Soluble sp|P44679|YBGC_HAEIN GENBANK NP_294626.1 GGQEHHTELRVRYAETDAMAVAHHATYPVWFEVARTELMHALGLPYTEMETRGYYLMLSGLHVQYRRAARYDDRLD ITTRITEIRSRTLKFAYEVHRIGADGTRELLATGETHHIATDHQYRPSRMPDDVLALLAGEG Deinococcus radiodurans NYSGXRC-2713a SGX Pharmaceuticals 2003-07-07 active Selected Cloned Expressed Soluble Purified gb|AAG04925.1|AE004582_3 ICEDB: T1565 GENBANK NP_418173.1 TQNIRPLPQFKYHPKPLETGAFEQDKTVECDCCEQQTSVYYSGPFYCVDEVEHLCPWCIADGSAAEKFAGSFQDDA SIEGVEFEYDEEDEFAGIKNTYPDEMLKELVERTPGYHGWQQEFWLAHCGDFCVFIGYVGWNDIKDRLDEFANLE EDCENFGIRNSDLAKCLQKGGHCQGYLFRCLHCGKLRLWGDFS Escherichia coli NYSGXRC-2713d SGX Pharmaceuticals 2003-05-19 active Selected Cloned Expressed Soluble Purified gb|AAG04925.1|AE004582_3 ICEDB: T1451 GENBANK NP_250227.1 NPPLPHFRYHPEPLASGSIEASATTCQCCGKARGYVYTGSPYSRHELPPGSLCPWCIADGSAAARYEASFSDDYPL LDAGVAADIVTEVCERTPGYTSWQQERWLVCCEDACAFRGDAGREEIGQLGAEGLAQRFADFAWPAITWQRLVDA YTPGGNPAIYRFDCLHCGQAHYDLDFT Pseudomonas aeruginosa NYSGXRC-2715e SGX Pharmaceuticals 2009-06-24 active Selected Cloned Expressed Soluble Purified Crystallized gb|AAG04677.1|AE004558_6 GENBANK NP_230688.1 NNMRLFKKSLLAVTVTLATQQAFAAGFQLNAQSATGLGRAFAGDAVIADNAAVMSRNPAAMALFDEMALSLGFETI TTMIDVKNVSYRGVLGNSVSVQDTDDVGGTSVAPNIHLIVPVNEQFAWGVNAYSNFGTKTEFSDSYPASEYGGLT DVKSFNLGLAGSYRVNKEWSFGAGLDLIYGQGTMKRIAGTSFPASTIVVNPTTVIPARGTSLLNVDKADGWAVGF NLGTVYEMDENNRFGLSYRYSPEFKAKDDYGQEITLPLPDIAEFSGFHKIENTQFAVHYSVQWIGWSAFDKIEFR NLVTSRSSVGALTKGSYDKMYEWQDGWHYSIGGTYYLNSDWTLRAGYMYDTSAQDSRTSISVPDSDRQWLSAGFT YNIDDKSNVDFGFTYLMGKDVAVSENDAGSKLTATTHADAILLGLQYSRTF Vibrio cholerae NYSGXRC-2718c SGX Pharmaceuticals 2003-06-17 active Selected Cloned Expressed Soluble gb|AAG07721.1|AE004849_8 GENBANK NP_143527.1 REYIKEGIKLAVTNIPEDVVSAIREALEREESKIAKYNLEMILKAIDISRKEGIPVCQDTGTPIFFVRTNGPINKI YDEIVKGVEIATREVPLRPNALHVLDGKVIGNVPEVHFEPGKETLISILMKGGGSENCTALFPLTPAEGLEGVKN KVIEHVQSCGGKPCPPIIVGIGIASPAEKAIILAKKALLRRISERHPNEKLAKFERELLEEINSLGIGPMGLGGR TTALDVKVEVETRHPASYIVGVVIQCWAHRRAFIKVSEGGVKIWQ Pyrococcus horikoshii NYSGXRC-2718d SGX Pharmaceuticals 2003-05-21 active Selected Cloned Expressed Soluble gb|AAG07721.1|AE004849_8 GENBANK NP_248294.1 KISDVVVELFREAAIYLPEDVKNALEEAYKKESSEISKNTLKAIIENNKIAEETQVPLCQDTGVPIVFLKIGKNIN SSEIMKIIEEIKEGVKKATEEVPLRPNVVHPLTRENFKTNVGLNSPFINIEFDESLDREIEIIAFPKGAGSENMS ALKMLKPSDGIEGIKNFVLETIANAGGKPCPPIVVGIGIGGTADVALKLAKKALLRKIGERHRDKEIANLEKELL EKINSLGIGAMGLGGDITALDVFIEIAGCHTASLPVGICIQCWADRRAIKRIKLDAK Methanococcus jannaschii NYSGXRC-2718e SGX Pharmaceuticals 2003-05-21 active Selected Cloned Expressed Soluble gb|AAG07721.1|AE004849_8 GENBANK NP_069928.1 EYNDVVEAVISALKKAHTELPEDVVTAIKKAYDSEENDIAKRNLEAILKNIEAAKKLGVPMCQDTGIPVFFVEVGR ELCLDFDLKEAIVEGVRKATAEIPLRPNAVHPITRENSGDNTGLGIPQINVELVKGDELRMVVMPKGAGSENVSA LKMMLPTQVDKIKDFVVETVKNAGGKPCPPIFVGVGVGSTFDGAAKLAKKALLRNVLEMNDFELELLEAVNELGI GAMGLGGKYTALAVLVEFGHCHTASLPVAVNIQCWANRRAEVVLR Archaeoglobus fulgidus NYSGXRC-2718f SGX Pharmaceuticals 2004-06-08 active Selected Cloned Expressed Soluble Purified gb|AAG07721.1|AE004849_8 ICEDB: T1566 GENBANK NP_228350.1 INKHVISEKIKKAIVEANIKINPEVEEIIERYEGPFSDIIKENYRVSKEEKLPLCQDTGIVEFFVFIGHEVKLEEP IEETLNRAVGEVYSEYPFRYSVVSDPLFERINTGTNTPAIVHIFQVKGKSLEIRFLVKGGGSENLTVLRMMTPTS DVEKVKEFVIEHIKEHGAKACPPLHVGIGIGGTADKALLLSKLALTKSFKERNKDPKYAGLEKELEKELNFLGIG FQGLGKGITVYSVHIEHFPTHIATLPVAVSVDCYLCRRGKVTFED Thermotoga maritima NYSGXRC-2718g SGX Pharmaceuticals 2003-08-01 active Selected Cloned Expressed Soluble Purified gb|AAG07721.1|AE004849_8 ICEDB: T1463 GENBANK NP_253023.1 AVIKQDDLIQSVADALQFISYYHPVDFIQAMHEAYLREESPAARDSMAQILINSRMCATGHRPICQDTGIVTVFVR VGMDVRWDGATMSVDDMINEGVRRAYNLPENVLRASILADPAGARKNTKDNTPAVIHYSIVPGDKVEVDVAAKGG GSENKSKMAMLNPSDSIVDWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAAVMAKEVLMDPIDIHELKARGPQNRI EELRLELFEKVNQLGIGAQGLGGLTTVLDVKIMDYPTHAASLPVCMIPNCAATRHAHFVLDGSGPAELEAPSLDA YPEIVWEAGPSARRVDLDKITPEEVQSWKPGETLLLNGKMLTGRDAAHKRMVDMLNKGETLPVDLKGRFIYYVGP VDPVGDEVVGPAGPTTATRMDKFTRQILEQTGLLGMIGKSERGPIAIEAIKDNKAVYLMAVGGAAYLVAQAIKKS KVLAFAELGMEAIYEFEVKDMPVTVAVDTNGESVHITGPAVWQKKIAESLAVEVK Pseudomonas aeruginosa NYSGXRC-2718h SGX Pharmaceuticals 2003-10-21 active Selected Cloned Expressed Soluble Purified gb|AAG07721.1|AE004849_8 ICEDB: T1567 GENBANK NP_230949.1 TVIRKQDVISSVADALQYISYYHPLDFVKALEKAYQREESQAAKDSIAQILINSRMSAEGHRPICQDTGIVTCFVN IGMGVQWDSTDMTVQQMVDEGVRQAYTNPDNPLRASVLMDPAGKRINTKDNTPAVVHINMVPGDKVDIQIAAKGG GSENKTKMVMLNPSDDIAEWVEKTVPLMGAGWCPPGMLGIGIGGTAEKAAVLAKEALMEHIDIHELIERGPQNAE EELRLDIFNRVNKLGIGAQGLGGLTTVVDVKIKSAPTHAASKPVCMIPNCAATRHVHFTLDGSGPAQLTPPKLED WPQITWEAGANTRRVNLDNITREEIQTWKTGETVLLSGKILTGRDAAHKRIQTMLQKGEKLPDSVDLKDKFIYYV GPVDAVGDEVVGPAGPTTSTRMDKFTDMMLEEVGVMGMIGKAERGPATVESIKKHKAVYLMAVGGAAYLVAKAIK KARVVAFEDLGMEAIYEFEVEDMPVTVAVDSTGANAHQIGPDTWRVKIAEAAK Vibrio cholerae NYSGXRC-2719c SGX Pharmaceuticals 2003-08-18 active Selected Cloned Expressed Soluble gb|AAF97986.1| GENBANK AAF97986.1 IIPRRYNMMKKLINKKETFLTDMLEGLLIAHPELDLIANTVIVKKAKKEHGVAIVSGGGSGHEPAHAGFVAEGMLD AAVCGEVFTSPTPDKILEAIKAVDTGDGVLLVVKNYAGDVMNFEMAQELAEMEGINVQTVIVRDDIAVTNEVQRR GVAGTVFVHK Staphylococcus aureus NYSGXRC-2723d SGX Pharmaceuticals 2004-12-08 active Selected Cloned Expressed Soluble Purified sp|P31658|YEDU_ECOLI ICEDB: T1568 GENBANK NP_294214.1 TTSTPSNRILVVMSSAAQIPLQDGKNHNTGYFLNEFGVPAKRLTDAGYELVIATPRGSVPGMDHNSDHDMFFKNKE EHNEIKAFVGDVLSNTTIQTTEAVAAEGTQAYAALFLPGGHAPMADLMADPALGEILRQFHAAAKPTALICHAPT ALLAAQADPVAFQKGMEAGEQPSAQDFTYQGYRVTVFANDEEEATEKTFEAPMLYYPADALTQGGAQVENGEAMK PNVVRDRELLTGQNPFSDEPFVAQLLEMLG Deinococcus radiodurans NYSGXRC-2724g SGX Pharmaceuticals 2003-12-05 active Selected Cloned Expressed Soluble Purified gb|AAG07812.1|AE004857_3 ICEDB: T1511, T1659 GENBANK NP_296003.1 TSRPRGIHQGAAAEARAAAHLESLGREIVRRNYRIPGGEIDLVSREPGGTLVFTEVRQRRQARYGSALDSVTPRKL ALMHRAALEYLTRECGRDDLPCRLEVLTIEGEADTGELRLLAV Deinococcus radiodurans NYSGXRC-2725a SGX Pharmaceuticals 2001-03-16 active Selected Cloned Expressed Soluble Purified pir||B75570 ICEDB: T771 GENBANK NP_418632.1 IAITGATGQLGHYVIESLMKTVPASQIVAIVRNPAKAQALAAQGITVRQADYGDEAALTSALQGVEKLLLISSSEV GQRAPQHRNVINAAKAAGVKFIAYTSLLHADTSPLGLADEHIETEKMLADSGIVYTLLRNGWYSENYLASAPAAL EHGVFIGAAGDGKIASATRADYAAAAARVISEAGHEGKVYELAGDSAWTLTQLAAELTKQSGKQVTYQNLSEADF AAALKSVGLPDGLADMLADSDVGASKGGLFDDSKTLSKLIGHPTTTLAESVSHLFNVNN Escherichia coli NYSGXRC-2725c SGX Pharmaceuticals 2003-09-25 active Selected Cloned Expressed Soluble Purified pir||B75570 ICEDB: T1602, T1774 GENBANK NP_293737.1 NSTSSPTIAVTAATGKLGQLVVSSLLERGVPADHIVAIVRNPAKAQGLFAPGVQIRQADYNSPEGWDRALAGVQRL LLISSSDLNDRADQHRTVIEAASAAGVELLAYTSLLKADTARMSLAADHQATEKLLTESGVPFVLLRNGWYLENY DLAQALQTGSVLGAAGTGRISAASRKDLAEAAAAALTRDGQAGKVYELAGDEAFSLSELAAELSKQSGKDVQYRN FAPEDYQRTLEGFGLPAPVAQMLVSSDEGVARGELELPNSDLRELIGRPSTSLKEAVASQLA Deinococcus radiodurans NYSGXRC-2725d SGX Pharmaceuticals 2003-09-26 active Selected Cloned Expressed Soluble Purified pir||B75570 ICEDB: T1603 GENBANK NP_388569.1 MKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADAEYVYFNWKYASSFTPALEQVKQIYLVAPVGVFD PAPYVLPFLKEAKRLGAKRVVMQSASVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRI TTASGEGKLGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSISRSELQHKME AGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAHAAYWTSFWTE Bacillus subtilis NYSGXRC-2730c SGX Pharmaceuticals 2001-10-11 active Selected Cloned Expressed Soluble Purified pir||F70520 ICEDB: T815 GENBANK NP_273828.1 NTPQSAIIPDHAQAGIFIEADFAANRLNDIKAACRASLDALTALKARFPDDILGLTIAFGSKAWATFGHTDEGSEI KPFSEMGNGLAPSTQHDMSIHIQSFRQNAAYALAQSVLGAFGDSICVASEEHGLRLYQDRGLDGFVDGTENPQGD ENVREVAIIPEGKPDAGGSYVLLQKYLHDLKKWDAVPVAEQEASVGRGKETDDEFGRDVRLPDSHLGRVNLKENG VGLKIVRRSLPFGKISGEHGLMFTAYCRTLHNIEAQLLSMFGDTDGKTDLLLRHLSAAVSGGYYYAPSVERLQNL Neisseria meningitidis NYSGXRC-2730d SGX Pharmaceuticals 2003-10-09 active Selected Cloned Expressed Soluble Purified pir||F70520 ICEDB: T1569 GENBANK NP_231776.1 FKSQTAILPEAGPFALYTLLKVRQNHAHVLQALKALPALVEEINQNQPGAELTVSVAFSKGFWSHFEMASPPELID FPELGEGETHAPSTDVDVLIHCHATRHDLLFYTLRKGISDIAQDIEIVDETYGFRYLDARDMTGFIDGTENPKAE KRAEVALVADGDFAGGSYVMVQRFVHNLPAWNRLNLAAQEKVIGRTKPDSVELENVPAASHVGRVDIKEEGKGLK IVRHSLPYGSVSGDHGLLFIAYCHTLHNFKTMLESMYGVTDGKTDQLLRFTKAVTGAYFFAPSQVMLQELTLKNQ Vibrio cholerae NYSGXRC-2734d SGX Pharmaceuticals 2003-05-13 active Selected Cloned Expressed Soluble Purified gb|AAG07813.1|AE004857_4 ICEDB: T1440 GENBANK NP_253115.1 DMQHRIRQLFQASIETKQQALEVLPPYIEQASLVMVNALLNEGKILSCGNGGSAGDAQHFSSELLNRFERERPSLP AVALTTDSSTITSIANDYSYNEVFSKQIRALGQPGDVLLAISTSGNSANVIQAIQAAHDREMLVVALTGRDGGGM ASLLLPEDVEIRVPSKITARIQEVHLLAIHCLCDLIDRQLFGSEE Pseudomonas aeruginosa NYSGXRC-2734g SGX Pharmaceuticals 2003-05-21 active Selected Cloned Expressed Soluble gb|AAG07813.1|AE004857_4 GENBANK NP_439799.1 VKDIYSESIQIQIAASSMLSENITNATQMVMQCLLGGNKVIACGVSRSYANAQFLVSNLLNRYDLVRPSFPSVLLS LESAVGSSLVFEQPPEELYCHQFNASAKSGDLLIAFAPLGTEKIVLNIISHAVSKEVNVIVLTGSNNDAIQGILA DKDLEISIPATKESRILENHLFVINALCELVDQTLFPSA Haemophilus influenzae NYSGXRC-2734h SGX Pharmaceuticals 2003-06-19 active Selected Cloned Expressed Soluble Purified gb|AAG07813.1|AE004857_4 ICEDB: T1597 GENBANK ZP_01068234.1 ENLNSYIKGHFADSILVKEQILKDENLITLIKNASLEVIKAYKNGNKTLLAGNGGSAADAQHIAGEFVSRFYFDRP GIASIALTTDTSILTAIGNDYGYENLFARQVQAQGVKGDVFIGISTSGNSKNILKALEFCKQKEIISIGLSGASG GAMNELCDYCIKVPSTCTPRIQEAHILIGHIICAIVEEELFGKGFSCKQ Campylobacter jejuni NYSGXRC-2736d SGX Pharmaceuticals 2003-10-29 active Selected Cloned Expressed Soluble sp|P43994|YFJF_HAEIN GENBANK NP_230497.1 MMSSEMIHVEVVYALPHEQRVLKLVVEQSATVEEIIRTSGILQMYPEIDLTVNKVGIFSRNVKLDARVRDKDRIEI YRPLLADPKEIRRKRAEQAKAAANQS Vibrio cholerae NYSGXRC-2736e SGX Pharmaceuticals 2003-06-26 active Selected Cloned Expressed Soluble sp|P43994|YFJF_HAEIN GENBANK NP_253454.1 AEIAVEVVYALPERQALLRLSVPAGTSAREAVLLSGIAEAFPGLDVQGCPLGIFGKLLARPEERVLEAGERVEIYR PLIADPKEVRKQRAARARSEREGG Pseudomonas aeruginosa NYSGXRC-2737g SGX Pharmaceuticals 2003-10-30 active Selected Cloned Expressed Soluble Purified gb|AAF94935.1| ICEDB: T1775 GENBANK NP_230161.1 NPKTSEYQKQQRYQENEILEHAAEILANRYVRGDALTNPDATKEYVRCKLGSYEREVFALLLLDNQNRLIEFKELF QGTVDAASVYPREVVKAVLEVNAAAVIFAHNHPSGDSTPSQADRRITERLKDTLALVDVRVLDHIVTGDTCTSFA ERGWL Vibrio cholerae NYSGXRC-2738c SGX Pharmaceuticals 2004-04-13 active Selected Cloned Expressed Soluble Purified sp|P33382|YORB_LISMO ICEDB: T1543 GENBANK NP_233335.1 IVTTTPNIEGKRIVRYCGVIAGEAILGANIFKDLSAGIRDIVGGRSGTYERELEKARAIALEELQQHAVALGANAV VGIDLDYETFGKANGMLMVSVSGTAVVVE Vibrio cholerae NYSGXRC-2738h SGX Pharmaceuticals 2003-07-30 active Selected Cloned Expressed Soluble sp|P33382|YORB_LISMO GENBANK NP_069703.1 EKEIIITTTETVPQREVAEILGVVFGNTVRAKHVGKDILAGLKNIVGGEIEEYTEMLRDARMEALNRMIKEAKKLG ADAVVNVRFTTSQTMAGAAELLAYGTAVRLR Archaeoglobus fulgidus NYSGXRC-2744a SGX Pharmaceuticals 2003-12-05 active Selected Cloned Expressed Soluble Purified sp|P44830|SLYD_HAEIN ICEDB: T1642 GENBANK NP_289896.1 KVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDVAVGANDAYGQYDENLVQ RVPKDVFMGVDELQVGMRFLAETDQGPVPVEITAVEDDHVVVDGNHMLAGQNLKFNVEVVAIREATEEELAHGHV HGAHDHHHDHDHDGCCGGHGHDHGHEHGGEGCCGGKGNGGCGC Escherichia coli NYSGXRC-2744e SGX Pharmaceuticals 2003-12-03 active Selected Cloned Expressed Soluble Purified sp|P44830|SLYD_HAEIN ICEDB: T1643 GENBANK NP_249528.1 QIAANKAVSIDYTLTNDAGDVIDSSAGGAPLVYLHGAGNIIVGLEKALEGKNVGDELSVAIEPEDAYGEYSAELVA TLTREMFEGVDELEVGMQFHASAPDGGMQIVTIRDIDGDDVTVDGNHPLAGQRLNFKVKVVDVREANAEEIAHGH IHGEGGHHH Pseudomonas aeruginosa NYSGXRC-2744h SGX Pharmaceuticals 2003-08-20 active Selected Cloned Expressed Soluble sp|P44830|SLYD_HAEIN GENBANK NP_223769.1 QNHDLESIKQAALIEYEVREQGSSDVLDSNISKEPLEFIIGANQIIVGLEKAVLKAQIGEWEEIVIAPEEAYGVYE SGYLQEVPRDQFEGIELEKGMSVFGQTEDNQTIQATIKDFSNTHVMVDYNHPLAGKTLAFRFKVLGFREVSEEEI LASHHDSGTGCCGGHGGHGGKKGGGCGCSCSHG Helicobacter pylori NYSGXRC-2746c SGX Pharmaceuticals 2004-04-13 active Selected Cloned Expressed Soluble Purified pir||C82289 ICEDB: T1544 GENBANK NP_229959.1 SQAVSSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSLDAMQRGWDCLSLFAERLQDIP AENIRIVGTATLRTATNAGEFIAKANQILGHPIDVISGEEEAATIYKGVAHTSGGLGRRLVVDIGGASTELIIGE GFEAKALTSLKMGCVTWLERHFKDRQLTATNFNNAILAAKQMLDPILTQYTELGWNVCVGASGTVQALQEIMLAQ GMDEVITLTKLKRLQKQAMLADHLEELDIEGLTLERALVFPSGLSILIAIFESLNIEAMTLAGGALREGLVYEMV QDLRQEDIRARTIRCVQTRYQIDSAYGDQVATLASKLLAQCGGEAWINEPQAEMLLRTAAKLHEIGLTIDFKKGG EHSAYLLQHLDLPGYTRAQKHYLGEIVRRYREQLTSLPEQYALSGTSGKRVLRLLRLAVLLSHRRSPALEPMVEL SAQEDKLTLTLDGEWLAKNPLTRTELELEANRQTDIGWPLSIECH Vibrio cholerae NYSGXRC-2753c SGX Pharmaceuticals 2004-08-23 active Selected Cloned Expressed Soluble Purified gb|AAG07862.1|AE004861_3 ICEDB: T1545 GENBANK NP_230076.1 TMNQIETALLAPAGLTEQDIADTLSSIATRQIDYADIYFQSSWHESLVLEDSIIKDGSFNIDCGVGVRAVSGEKTG FAYSDQIQLEGLKQSAIAARGIAQQGQNLTVQAFKRAQHPAFYGAHNPLESWEKQQKTELLKQLDAYIRTKEPLI TEVSVSLSGVHEQILVAATDGTYAGDIRPLVRLSISVLAQKGDRRERGSAGGGGRFGYDYFLQEEAGQKIAFSFA DEAIRQALVNLEAVAAPAGTMPVVLGSGWPGVLLHEAVGHGLEGDFNRKGSSVFAGKVGKKVTSDLCTIVDDGTL KDLRGSLNVDDEGVSGQYNVLIEKGILKGYIQDKLNARLMGVAPTGNGRRESYAHLPMPRMTNTYMLPGEHTPEE IIASVKKGIYAPNFGGGQVDITSGKFVFSASEAYLIENGKITRPIKGATLIGSGIEAMQQVSMVGNDLALDRGVG VCGKAGQSVPVGVGQPTLKLDALTVGGTE Vibrio cholerae NYSGXRC-2758f SGX Pharmaceuticals 2003-07-11 active Selected Cloned Expressed Soluble Purified gb|AAG07826.1|AE004858_4 ICEDB: T1572 GENBANK NP_251043.1 PDTSPDLPAMSPLAVYRQAVEQRGFAPDEAQRRAAEALERCFQALHEAHRHGAIQGVYLWGPVGRGKTWLMDHFYQ CLRVPARRQHFHHFMQWVHQRQFELTGTADPLRALARELARDVRVLCFDELFVSDIGDAILLGSLLRIMFEEGVV LVATSNQPPEQLYADGFNRERFLPAIEAIQRHMAVVAVDGGQDHRLHPGRAEQRYWVVEAGQASGFAELFARLSA GEAASTQPIELGHRPLAVHRHSESVLWCSYAQLCEAPLSALDFIGLCDRYRAILMDDLPCLSASQREGRIARGTE DGAQLVEAGDRELPQLSVHDDGVRRFIALVDECYDRKVPLYLEARVPLEALYTEGYLAFAFRRTLSRLREMQLAR FGSDS Pseudomonas aeruginosa NYSGXRC-2760e SGX Pharmaceuticals 2003-08-12 active Selected Cloned Expressed Soluble Purified pir||XYECMB ICEDB: T1573 PFAM PF07728 GENBANK NP_388491.1 EISKQTSDLLLSLEKKKGTLPKFSVLRSIPRNRIIYGAPGTGKSNYLEREVGKIFGDNPYVFTRVTFFPGYTYGQF IGAYKPVPIYKKLSGEEEIFSSNFRDKMENFEPMIDYQFVPGPFIDVLIKALKNRYTNFILIIEEINRANAASVF GDIFQLLDRNKNGESDYPVTFGPDIMNYLARNGIKDEMIKLPSNFFIWATMNNADQGVLPLDTAFKRRWSFEYLE LEKYRKAVDSWKLSLRYKGHNKVIMWNDFRDIINKRLKGKVPEDKLLGPFFLKESELWNQNVFKNKLLYYLKEDV FKHNPTIDFLNASTFSELIEKYDGSDNIFTFDIDDSSFVSD Bacillus subtilis NYSGXRC-2763a SGX Pharmaceuticals 2006-01-20 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB sp|O28020|YM64_ARCFU ICEDB: T820 PDB 1PSU PFAM PF02575 PDB 2FS2 GENBANK NP_415914.1 SHKAWQNAHAMYENDACAKALGIDIISMDEGFAVVTMTVTAQMLNGHQSCHGGQLFSLADTAFAYACNSQGLAAVA SACTIDFLRPGFAGDTLTATAQVRHQGKQTGVYDIEIVNQQQKTVALFRGKSHRIGGTITGEA Escherichia coli NYSGXRC-2764f SGX Pharmaceuticals 2003-08-08 active Selected Cloned Expressed Soluble sp|P44509|Y093_HAEIN GENBANK NP_390745.1 FLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQFHEGALICAKERRSVIITKEDETRLKGVKAGINL PVFFDHDVISVFGLTGEPAEIQPFGELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQL LGVDLSSRRQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRKILHICSFAN TASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLDMCLTEISPGTRNEFPQRVLGKALEHQ ELMNTIRTFFHHDLSLKQTAEDMHIHINTLRYRLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK Bacillus subtilis NYSGXRC-2764g SGX Pharmaceuticals 2003-08-08 active Selected Cloned Expressed Soluble sp|P44509|Y093_HAEIN GENBANK NP_388205.1 EELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSYYINHFDSANQQTIFSKKCPVQIFERFLKDGIIE KLKTEPEPFRVNKIESIGLNQRVVVSAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEK EEKAEDLIKRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLRDKVSHVLTI ESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEYNHLLKLGKSYTEALEVIKAAEITGNQ ENIPYEYAKLGIYRYLESIEQKNEFLEYENKDLALLKAKDEESSTELLKTLEVYLLNNCKTKPAAEQLFIHQNTL NYRIKQITEMTSIDLSDFRTRCQLYLDLMLMKKK Bacillus subtilis NYSGXRC-2765c SGX Pharmaceuticals 2005-11-10 active Selected Cloned Expressed Soluble Purified pir||C82130 ICEDB: T1546 GENBANK NP_231643.1 VLQMKSGGVVSDARTELDTQRLAKYIGGKHALVAQGGGQRGIFTAGVLDAFLLSNFDPYHEFYGTSAGALNLCAFL SRQTGLSKAFILELTTRAEFFHLFSYIRRKQYMNMQWALDRIGEYPYRLDLDMARQALGKRKAYAAVTSADDLKD AYFPMLGADWQQVLLATCAIPGLYPEPVTLAGKQYIDGGVSASIPVQEAWRKEARFITVIRTEFMSKEEETPSPS ATELPLWLREPLNHLQHQLQHKWSGWRQEWNEFLQQQKLRAKEQKKEQKHLDALNGGRWLFGADDIYRLSHLLGS KFDAGLADLLMVHYQTYTLTSEFLDAHHDDTFIAQIMPSEPLHSNSLLSSPEALQYDYELGLKAGYRFLKAYSEA ETFRKELPRNLM Vibrio cholerae NYSGXRC-2770a SGX Pharmaceuticals 2001-03-16 active Selected Cloned Expressed Soluble Purified sp|P32699|YJBR_ECOLI ICEDB: T1410 GENBANK NP_290690.1 TISELLQYCMAKPGAEQSVHNDWKATQIKVEDVLFAMVKEVENRPAVSLKTSPELAELLRQQHSDVRPSRHLNKAH WSTVYLDGSLPDSQIYYLVDASYQQAVNLLPEEKRKLLVQL Escherichia coli NYSGXRC-2772a SGX Pharmaceuticals 2001-03-16 active Selected Cloned Expressed Soluble Purified gb|AAG06238.1|AE004711_10 ICEDB: T30, T770 GENBANK NP_415999.1 TIHKKGQAHWEGDIKRGKGTVSTESGVLNQQPYGFNTRFEGEKGTNPEELIGAAHAACFSMALSLMLGEAGFTPTS IDTTADVSLDKVDAGFAITKIALKSEVAVPGIDASTFDGIIQKAKAGCPVSQVLKAEITLDYQLKS Escherichia coli NYSGXRC-2772d SGX Pharmaceuticals 2003-12-05 active Selected Cloned Expressed Soluble Purified gb|AAG06238.1|AE004711_10 ICEDB: T1776 GENBANK NP_295261.1 HSGSVEHCIKGRSRRAAPRSEHTGRMADIARKASAHWEGDLKSGNGTITTESGVLSQAQYSFKTRFENGKGTNPEE LLASAHAGCFTMQLSALLAEHGHEIKALDTDATCEMVKDGPGFKINHMHLRVRAQLTGSDQADFEAHVKDAAEKC PLSRIMQGNVEVTHEAILEG Deinococcus radiodurans NYSGXRC-2772e SGX Pharmaceuticals 2001-09-25 active Selected Cloned Expressed Soluble Purified gb|AAG06238.1|AE004711_10 ICEDB: T1427 GENBANK NP_389197.1 SQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEKATNPEQLFAAGYAACFDSALQLVARTERVKVET EVTANVSLLKDEADQGYKLGVTLQVKGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE Bacillus subtilis NYSGXRC-2772f SGX Pharmaceuticals 2003-07-22 active Selected Cloned Expressed Soluble Purified gb|AAG06238.1|AE004711_10 ICEDB: T1574 GENBANK NP_389199.1 ALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNPEQLFAAGYAACFGGALEHVAKEQNIEIDSEIEG QVSLMKDESDGGFKIGVTLVVNTKDLDREKAQELVNAAHEFCPYSKATRGNVDVKLELK Bacillus subtilis NYSGXRC-2772g SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified gb|AAG06238.1|AE004711_10 ICEDB: T1604 GENBANK NP_251540.1 QTIKALYTATATATGGRDGRAVSSDGVLDVKLSTPRELGGQGGAATNPEQLFAAGYSACFIGALKFVAGQRKQTLP ADASITGKVGIGQIPGGFGLEVELHINLPGLEREAAEALVAAAHQVCPYSNATRGNIDVRLNVSV Pseudomonas aeruginosa NYSGXRC-2774c SGX Pharmaceuticals 2003-08-08 active Selected Cloned Expressed Soluble gb|AAG05393.1|AE004627_1 GENBANK NP_388691.1 NSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPYLEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEK LLPAIKEMEMMALLIDSDGVVLALDGHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSI ASHLWNCSAAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRFGERAASSVP MVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGGTCFYLSEQKKKKAFRFNGVIGQSGRS QAMLMHLERAAATDASVCLSGETGTGKEVAARALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKR NGYKGAFQKANQGTLFLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIRED LFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNIRELFNVFERLSIRFPDGRL RDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDMMIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLS AES Bacillus subtilis NYSGXRC-2776a SGX Pharmaceuticals 2001-03-22 active Selected Cloned Expressed Soluble Purified sp|P43749|HOLC_HAEIN ICEDB: T769 GENBANK NP_418680.1 KNATFYLLDNDTTVDGLSAVEQLVCEIAAERWRSGKRVLIACEDEKQAYRLDEALWARPAESFVPHNLAGEGPRGG APVEIAWPQKRSSSRRDILISLRTSFADFATAFTEVVDFVPYEDSLKQLARERYKAYRVAGFNLNTATWK Escherichia coli NYSGXRC-2779c SGX Pharmaceuticals 2003-07-11 active Selected Cloned Expressed Soluble Purified gb|AAG06013.1|AE004691_4 ICEDB: T1502 GENBANK NP_251315.1 SWHPHVTVATIVEDQGRFLLVEEQADGREVLNQPAGHLEPAESLLEAALRETLEETGWEVELSAVTGIYLYTAPSN GVTYQRVCFAARPVRHHPERALDDGIIGPRWLTRDELAAQPQRWRSHLVLRCIDDYLAGGRYPLALIRDTHVSPS L Pseudomonas aeruginosa NYSGXRC-2781d SGX Pharmaceuticals 2003-07-25 active Selected Cloned Expressed Soluble Purified sp|P45390|YRBC_ECOLI GENBANK NP_439241.1 KKWFTILTFVLTAFLVTRTAIAETSPYVLMQQAADKLFSDIQANQSKIKQDPNYLRTIVRNDLLPYVNLEYAGSKV LGSYYKSTSAEQREKFFKTFGELIEQKYAQALTNYSNQKIQIESEKELGDNNFINIRVNIIQANGVAPILLYFKW RKGNKSGEWKVYDMVGAGVSMLEDTIKNWVGILNKQGIDTLITKMQQSASQPIIFNQ Haemophilus influenzae NYSGXRC-2785c SGX Pharmaceuticals 2003-08-12 active Selected Cloned Expressed Soluble Purified sp|P42406|YCKH_BACSU ICEDB: T1486, T1497 GENBANK NP_388229.1 SRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELKTLIPDITQKILVNQLREREQDMIVHREVYPVVP PKVEYSLTPHGESLMPILEAMYEWGKGYMELIDIDKNVMKESL Bacillus subtilis NYSGXRC-2785d SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble Purified sp|P42406|YCKH_BACSU ICEDB: T1498 GENBANK ZP_01067635.1 YHSLCPIETTLNLIGNKWKILIIRDLLQGTKRFGELRKSISFTKNQNISQNVLTQNLRELEEAKLIKRKVYAEVPP KVEYSLTSLGNSLESILKSLENWGNSYKNIV Campylobacter jejuni NYSGXRC-2785e SGX Pharmaceuticals 2003-08-15 active Selected Cloned Expressed Soluble Purified sp|P42406|YCKH_BACSU ICEDB: T1499 GENBANK NP_388410.1 RNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKKRFNEFRKLYPKITQRMLTLQLRELERDGVIHRE VYKQVPPKVEYSLTEFGRTLEPVILHMKDWGEKYKDRIDKLEAARKAEDKI Bacillus subtilis NYSGXRC-2785f SGX Pharmaceuticals 2003-08-15 active Selected Cloned Expressed Soluble Purified sp|P42406|YCKH_BACSU ICEDB: T1504 GENBANK NP_391934.1 KKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNEFRRICPSITQRMLTLQLRELEADGIVHREVYHQVP PKVEYSLTEFGRTLEPIVLQMKEWGESNRDVLESYRSNGLVKDQQK Bacillus subtilis NYSGXRC-2785g SGX Pharmaceuticals 2006-08-09 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB sp|P42406|YCKH_BACSU ICEDB: T1496 PDB 2HZT PFAM PF01638 GENBANK NP_390781.1 EKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMPNITQKMLTQQLRELEADGVINRIVYNQVPPKVE YELSEYGRSLEGILDMLCAWGANHINRVYGDTFSVLEESVLNDKLKQES Bacillus subtilis NYSGXRC-2785h SGX Pharmaceuticals 2003-08-22 active Selected Cloned Expressed Soluble Purified sp|P42406|YCKH_BACSU GENBANK NP_389259.1 KKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNITQKMLIQTLRELEASGLVSRKMYNQVPPKVEYS STELGESLKPILQELCQWGGYYAEQEYAEGEYEIVQPEQLS Bacillus subtilis NYSGXRC-2789c SGX Pharmaceuticals 2003-12-05 active Selected Cloned Expressed Soluble Purified gb|AAG04398.1|AE004533_9 ICEDB: T1487 GENBANK NP_231790.1 TQHLVITAVGTDRPGICNEVVRLVTQAGCNIIDSRIAMFGKEFTLLMLISGSPSNITRVETTLPLLGQQHDLITMM KRTSPHDHQTHAYTVEVYVESDDKLGLTEKFTQFFAQRQIGMASLSAQTISKDKLHSEQNQFHIAISARVDSGCN LMQLQEEFDALCTALDVQGSLNFIKNSQ Vibrio cholerae NYSGXRC-2789d SGX Pharmaceuticals 2001-03-09 active Selected Cloned Expressed Soluble gb|AAG04398.1|AE004533_9 GENBANK NP_249700.1 TSQPREQFLLISALGPNPMELTTLLCRACVESRCAVVSSRLTRHGEFSALVLQISGSWDALARLEGSLPALTKRGD ITLSMTRSNAHVTRAQALPYVAYVSAVYRPDILNELCQFFIDHNIELENLTCDTYQAPHTNTTMLNATITVTLPA GTQISWLRDQFLDFADALNLDALIEPWR Pseudomonas aeruginosa NYSGXRC-2793f SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble Purified gb|AAG06431.1|AE004729_5 ICEDB: T1547 GENBANK NP_231613.1 QVSLNPEWLARNNDEHKIRRNDHRSPFQRDRARILHSAAFRRLQAKTQVHGTSLNDFHRTRLTHSLEAAQIGTGIV AQIKLKQPEFRELLPSDSLIDSLCLAHDIGHPPYGHGGEIALNYMMRDHGGFEGNAQTFRIVTSLEPYTEHHGMN LSRRTLLGLLKYPALLSATRAAIPPPAVAHQRQLKAKDWSPAKGIYDCDLASLDWVLEPLCESDRELLGQMRAEP SSPKEHRKTRFKSLDCSIMELADDIAYGVHDLEDAIVLGMVTRAQWQEAAAAQLAECGDPWFEEHIAELSEMLFS GKHYVRKDAIGGIVNALLTSISVKPVEAPFHNELLAFNAYIEPHMGNALEVLKHFVSQYVIQIPQVQRFEYKGQQ LIMDLFEALSADPERLLPQATGEKWRKAQEQDEGMRVICDYIAAMTDAYAQRLHQQLFSAQSHY Vibrio cholerae NYSGXRC-2793g SGX Pharmaceuticals 2003-10-07 active Selected Cloned Expressed Soluble gb|AAG06431.1|AE004729_5 GENBANK NP_232704.1 YDSEVIEYAKEQENIISKLEYRVYKHDDGRSVNRQDLMRDYARVLYSSSFRRLQGKMQLLGVDASKFNRNRLTHSL EVAQIARSIAYDLELNHTVVAETASLAHDIGNPPFGHYGEVVLNDLSLACGGYEGNAQAFRILRTLEKKHYAYPG LNLNVRTLMAITKYFFNKHQNNKKFLYDADYEFLKTELDSKGVTVTKSIDAEIMDLADEIAYAAHDLEDALSFGM ISLGEIVHEFSISDKFKDAYPTMTDIAKEAQNVAMKASRSGTSEEYAIVLKKELTSMIVNILCSDIGLVDGCLGY KRHAKLAEGLKKLLFKAILRKKDIQLYERRGEQIIRGLFEVYSDEKYNKDNMLLPPELRAINDCKTRLVTDYISG MMDSYAAQEYEKYFGKGSADKLYFK Vibrio cholerae NYSGXRC-2795d SGX Pharmaceuticals 2001-03-20 active Selected Cloned Expressed Soluble gb|AAG03812.1|AE004479_7 GENBANK NP_232929.1 KTLMAVGLAAVMSIPFAANAADYVIDTKGAHASINFKVNHLGYSYIKGRFNKFDGEFSYDPANIAASSVVVNVDTR SLDSNHAERDKHIRSADFIDASKYSTATFKSTEVVDKGNGQLEVKGDLTLHGQTKPIVINAEFIGAGQDPWGGQR SGFAGTTRLELKDFGIQVMGASSYVDMELHVEGVQK Vibrio cholerae NYSGXRC-2800d SGX Pharmaceuticals 2003-10-29 active Selected Cloned Expressed Soluble pir||C82218 GENBANK NP_230933.1 IRVSSAVQRHAQKLIVLFSLLFGASLLMSDNGFATDIKNTNASSPVNSESTKPTKAGEVKNVVRFAKTGSFDNDTV VRLARQLAKKPYVALKDPLPESLANISYDEYRDIRFKPDSAVWKADGLPYQMQLFHRGFFFQDLIEIALVEGNQA THLSYDPNMFTAGEVLQQNLPTEDIGYSGLRVHYPLNSPSYFDELFVFQGASYFRALGKGNAYGLSARGLAIKTA DPAGEEFPIFRAFWVEKPNYDTNLIVVHALLDSPSVSGAYRFSIRPGENTRMDVEAVLFPRVELSKVGLAPATSM FMHSPNGREKTDDFRPSVHDSDGLLMINGRGERLWRPLANPSTLQVSAFMDNSPQGFGLMQRERDYANYQDLEAH YEKRPSLWVEPVGNWGPGAVVLTEIPTQSEIHDNIVAFWKPAQPLAAGSEYRFSYHLNWGAQPEANPQAITVSRT ASGRADIAKPTPKRLFVIDYQVQGAKPAQMPEPKVRSNAGVISNVVLRDNPANNGYRLSFEFDPGEVTLAELRAE LTLQEARPVETWLYRWTL Vibrio cholerae NYSGXRC-2801c SGX Pharmaceuticals 2006-06-12 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB sp|P43980|YQGE_HAEIN ICEDB: T1503 PFAM PF02622 GENBANK ZP_01678038.1 PDB 2HAF SNHSSDIEVGHSMNLTNHFLVAMPSMKDPYFKRSVIYICEHNQDGAMGLMINAPIDITVGGMLKQVDIEPAYPQSH QENLKKPVFNGGPVSEDRGFILHRPRDHYESSMKMTDDIAVTTSKDILTVLGTEAEPEGYIVALGYSGWSAGQLE VELTENSWLTIEADPELIFNTPVHEKWQKAIQKLGISPAQLSSDAGH Vibrio cholerae NYSGXRC-2801f SGX Pharmaceuticals 2004-12-09 active Selected Cloned Expressed Soluble Purified sp|P43980|YQGE_HAEIN ICEDB: T1598 GENBANK NP_438471.1 MELQGKFLIAMPHLDDYFNRTVVFMCEHNEQGSMGLVINQPTDLSIAELYSKLNFMMKNDRTFGNEMVVAGGPMHT ERGFILHKNTLNAFQHTYKVTKELSMTTSADVVETLGSTFAPEKYLVALGCSSWGAGQLEKEIRDNAWLVVSSND QILFDMPYEDRYAAANQLLGIHPYNFALAQVGHS Haemophilus influenzae NYSGXRC-2807c SGX Pharmaceuticals 2004-06-09 active Selected Cloned Expressed Soluble Purified gb|AAF96483.1| ICEDB: T1778 GENBANK NP_231795.1 KFFPTRTLLCLCIAAPCLPAIAQNDPIELPDIGTVAGSTLTIDQELIYGDAYMRMLRNNQPVINDPVLNEYIDNLG HRLVASANDVKTPFTFFMIRDRNINAFAFFGGYVALHSGLFLHAQSESELASVMAHEIAHVTQRHLARSMEEQAR RSPATIAALAGSLLLAIAAPEAGIAAINATMAGSIQGQINYTRSNEKEADRFGIATLAKAGFDANAMPQFFTRLA DEYRYASKPPPMLLTHPLPEDRITDSRERARQYPPLKLAPHLDYHLARARIIARYAGIDADAALDWFARSEKKID ATLQPSIQYGKALVYLDLKQFDKAEPLLTQLVKEQPDNHFYLDAISDLYIELKQADKAQSLLEKALKQTPNNSVL TINYANVLLKQDKFTDAIRILQRYTHDNPNDINGWQLLSEANSRLGNSAEDLAARGEIMALQANWNKAIQFYTQA SQLVELGSLAQARYDARIDQLMVQRERFLSLQ Vibrio cholerae NYSGXRC-2816e SGX Pharmaceuticals 2003-08-01 active Selected Cloned Expressed Soluble Purified sp|P44088|Y977_HAEIN GENBANK NP_439140.1 PPKFWIIIIVKKIDQQSLENAYRLFESGDIHQIEIGSTKGLQQIHHYLFNGLYEFAGKIREQNISKGHFRFANALY LKEALGKIEQMPEDTFENIINKYVEMNIAHPFLEGNGRSTRIWLDLVLKKHLGKVVNWQNVDKTQYLQAMERSPI NDLEIRFLLQANLTDDVNNREIIFKGIEQSYYYEGYEKE Haemophilus influenzae NYSGXRC-2817d SGX Pharmaceuticals 2003-08-18 active Selected Cloned Expressed Soluble Purified pir||F69458 ICEDB: T1605 GENBANK NP_070837.1 VIRMAYSELYWQKEEVMPKKELEELQLKRLRWVVRHAYENVAHYRRKLKEAGVHPDDIKKREDIAKIPFTTKKDFA ENYPFGLFAVPKEEIVRLHTSSGTTGKPKVVGYTANDLENWINLVARCLYMVGVRKHDIFQNMANYAFFTGGLGI HDGAERIGAMVIPAGVGNTERQVRCMADFGTTAIHSTPSYALHVKEVAEELGVDDKLSLRIGCFGAEPWSENTRK RLEDAFNIKAFDSYGLSEMNGPGVAFECEEQHGLHIWADHYFIEIIDPQTGEPLSEGEKGELVLTPLTKEALPVL RYRTGDITYIMDDECSCGRTHPKIHRILGRSDDMIIVRGINVFPSQIEHVLMQIPEVGDHFQVVITRNGTLDEIT VRVEVRDELFTGELFDLQRLQQKVQRELQKELGLRTNVELVEKGTIERSKGKAKRVLDLREEL Archaeoglobus fulgidus NYSGXRC-2817e SGX Pharmaceuticals 2003-09-08 active Selected Cloned Expressed Soluble pir||F69458 GENBANK NP_070499.1 YWNPAIERLNAKELEEIQERKLKALVSTVYQYSPFYRQRFREAGVTPDDIKSLNDLPKLPFTKKQDLRDTYPFGMF CVPLSQVVRFHASSGTTGKPTVVGYTANDIRNWVESLCRALVSCGVSSDDIMQIAYGYGLFTGGLGFHYAAERLG ATVLPISAGNTARQIELMKDLGSTVMACTPSYMIYLAEYASQMGVDIAEDTNLRAGIFGAEPWSEETRKRIEDKT GITAYDVYGTSELSGPLFTECTERQGLHIWADMFLIEIIDPKTGEQVGEGEKGELVVTTLTKEALPLIRWRTGDI TYMETDKCACGRTHPRIMRILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGLDELTVQVELS DKAEIDTTGDILKLEKKIADKLKSVLNVWAKVEVVNPGTLQRFEGKAKRVIDRRKI Archaeoglobus fulgidus NYSGXRC-2817f SGX Pharmaceuticals 2003-08-08 active Selected Cloned Expressed Soluble pir||F69458 GENBANK NP_069903.1 KDVARDIYLSRDKIDEIKRKRFRSTLKYVYDNSPFYRRLFKESGVDIDSIKEPADIAKLPFTTKQNLRESYPLKMA CVEKEKIVRIQMSGGTTGQPVIIPYTRHDVEQWKEMLLRDFYLAGITSKDVIQITPAFGLWNGGFGFHFAADAID AFVIPIGAGNTRNQVRFMVDFGTTVLCATASYPLRIAEVAEEMGYEPAELPVQKMLLGAEPWSEEMRRQIEKTFN CKAFDIPGLTEMGGVGTVGFECPSRNGLHIWEDNYIVEIVDPETGEVLEDGEEGEIVYTSLNREAMPLIRYRSGE VSAVVSREKCECGIEHMTIKRIRGRTDDMVIYKGVKFYPSDVEQILASYGVRHYRIEVGEGIRVIFEGENGLARK VIKDIKEFLGFSPRIEVVQPGSLERFEGKAKRLFRG Archaeoglobus fulgidus NYSGXRC-2818e SGX Pharmaceuticals 2004-07-26 active Selected Cloned Expressed Soluble Purified gb|AAG08830.1|AE004957_5 ICEDB: T1618 GENBANK NP_070680.1 DYQKEYERKLISPEEAANLVKDGMHIEIGGSANTALIIDKYLAKRKDELSHVEVGTFIDIAHYEFLKADPEQEKIK WESCFLYEPVRKCSKELGPCVHRPGVLSDAGYIAKELGGVLKGGKKYTDIAFLVTTPMDRHGFFNFGVTCTFLKS IAEGAEKVVVVVKKDMPWVNGGYDECIHISEVDYIVEDNEFPTPFLPFLPPPSKEDEMIAENIMEAGLIENGSTL QVGIGGLPNTVVRMLKEAGLKDLGIHTEMMGDGLMELMEEGIVTNQNKKLDRGKAVFSFALGTRKLYDFLDRNPE VATYPVEYTNNPFVVAQQPKMFSLNQVAQIDLMGQINSGQIGLTSPSGKIFQISGTGGQLDFVLGCFYSFDRQGK SVLATYSTYNGTSRIIPALPTGAGVTVPRSVVQYVATEWGIAYLRGLPIYKRAAAMIQLAHPDHRDWLEEEARKL GILPPKYSIPAGKADGVIYRRD Archaeoglobus fulgidus NYSGXRC-2820e SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble Purified gb|AAG08759.1|AE004950_2 ICEDB: T1606, T1607 GENBANK NP_389589.1 PKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLGALRHYFSTQDELLAFAMKLVQEKVTDRIKDIAV RDLLPKEKVLQILLEMVPTNEETIREMEVWFAFTAYARHKKDMFDASHDGIFSGMRNLIAYLDESDLLKQNADKD IEAERLYALVDGLALHAMLDPVRVNKDRIKRVIMQHVESICVEDTRETQKRHP Bacillus subtilis NYSGXRC-2823c SGX Pharmaceuticals 2003-11-04 active Selected Cloned Expressed Soluble Purified gb|AAG08408.1|AE004915_3 ICEDB: T1549 GENBANK NP_231565.1 KRSSICYRASKPLIASLVMSVWNAVHLSRRFAALPQAFYTPVHPQPLQNVRWGMWNSRLAQQFGLPEAPNDELLLS LSGQQLPADFSPVAMKYAGHQFGVYNPDLGDGRGLLLAEMATKQGEVFDIHLKGAGLTPYSRMGDGRAVLRSSLR EYLCSEAMAGLGIATTRALALMSSETPVYREREERGALLVRLAHTHVRFGHFEHFFYTDQHANLKLLADKVIEWH FPDCVQTSKPYAAWFSQVVERTALMIAQWQAYGFNHGVMNTDNMSILGETFDYGPFAFLDDYDPNFICNHSDYQG RYAFDQQPRIGLWNLSALAHALSPLIDKDDLEAALGSYSERLNLHFSRLMRAKLGLATQQEGDGELFADFFALLA NNHTDYTRFLRELSCLDRQGNEAVIDLVLDREAAKTWLTRYLERAARELGQEGRPISTRERCQAMRQVNPKYILR NYLAQQAIEFAERGDFEEMQRLATVLASPYAEHPEFERYAKLPPEWGKKLEISCSS Vibrio cholerae NYSGXRC-2825d SGX Pharmaceuticals 2003-08-07 active Selected Cloned Expressed Soluble Purified gb|AAG06393.1|AE004725_6 ICEDB: T1609 GENBANK NP_439120.1 SSLLIDLKGKELEQEEVELLSHPLVAGLILFTRNFENREQIQELIRSVRQRVKKPLLITVDQEGGRVQRFRDGFTM LPSMQAFQETLSATEQVSFAKEAGWQMAAEMIALDIDLSFAPVLDLGHECRAIGDRSFSSDVKSAVNLATAFIDG MHQAGMASTGKHFPGHGHVLADSHLETPYDDRTKEEIFSGDLQPFQQLISQNKLDAIMPAHVIYSQCDSQPASGS KYWLKEILRKKLNFQGTIFSDDLGMKGAGVMGNFVERSKKALNAGCDLLLLCNEREGVIQVLDNLKLTENQPHFM ARQARLQSLFKRRVINWNDLISDQRWRLNYQKLADIQSRWLDIQAAKND Haemophilus influenzae NYSGXRC-2827h SGX Pharmaceuticals 2003-08-13 active Selected Cloned Expressed Soluble Purified sp|Q46808|YQEB_ECOLI ICEDB: T1577 GENBANK NP_391131.1 GNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKGRRIGLLSGGCVEEDVFQRISALGDQLTSTLIPY DMRSEDDLSWGMGAGCNGIIHVHAERITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAP LQDIQRTVSTLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYCTSSLFPKAD QLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGLLGSANRTKRLLSGKHPPSHFYSPVGL KIGAEGPEEIAVSVVAEIIQTRKRVAVV Bacillus subtilis NYSGXRC-2832c SGX Pharmaceuticals 2003-09-09 active Selected Cloned Expressed Soluble Purified pir||H82281 ICEDB: T1550 GENBANK NP_230432.1 KTVFKPTLLAVLVAASAPVLAHSLIADTKAPSPTTKAFAAEQRNTLPFADQEDFKLVEKGLIAQQKDLEIKDANGK VVWELGNYRFLLDGLDYDSIHPSLQRQAQLNMHHGLYKVTDRIYQVRGYDLANITFVKGDTGWIVFDPLTVPATA KAALDFVNQELGERPVKAVVYSHAHADHFGGVKGIVSQEQVDRGEVPIIAPKGFLNHAVAENVLAGNAMSRRTTY QYGNVLPKGATGQVDAAIGKNVAQGEVSLIAPTKVISEQTETVVIDGVTMEFQNTPGTESPAEMNTYFPQFKALW MAENTVGGLHNVYTLRGAEVRDAKAWSKYINESIHMYAKEADVMFASHTWPRWGNDNINHFLRKQRDMYGYIHDQ ALRLANHGVTINEIQDEFHVPDVLAHEWYNRGYHGSYHRNAKAVINKYLGYFDMNPATLRPLAPTDAAPKYVAAM GGMDNVIKLGKEAFDKGEFRWCAEIVDKAVFAEPSNKQARYLQADCLEQLGYQSESAGERNTYLMGAYELRNGVP KVSATKTAGADTVVAMDTELFLDYLGVRLNGDKAAGIDYTINFVLPDVNEKFLVELENAHLNNLKGIQSENPDMT LTLNRAQLNQVLMGKTTIQQLAKEGKAKIEGNAQALTDIAGMLDNFEFWFNIIEPKTK Vibrio cholerae NYSGXRC-2836c SGX Pharmaceuticals 2003-10-15 active Selected Cloned Expressed Soluble Purified pir||H75587 ICEDB: T1551 GENBANK NP_285654.1 SNALVNPREAPAHGRFVPAPILAHRNCTQGALNMLEAKLKPHREYLLAQSAGQKLFLTLTVKPTAEARQARPDLSV VFVVDTSGSMREVVTEPTERTGRTTQVDGQVYEVVKGGKNKMQLMIEALRGIVTSTLIRPGDRLALVKFDDTAEV LVPFITASNQAQLAAAVDKLDWYSGGTHMGAGMRAGAGLLTGERGSRRMVLISDGQTFDAPLVEDQIGALAGLQV PVTVVAVGDEVNADLLTAIADRTQGQPLDIVPDTQNPQPPAIRASELPAALLGDLQKAAAEVVTGVALSVRTVKD VVLERVTRVQPTQTEVALRADGPLPLGNVDAGSGATFVLEFTLPARPATKMRLAQLGLTYEVPGANYRGEIPPLD VVVEFTGEEALAARIDPEVMGWVQQRNIEGLVAQATREANQNPEQAAKTLEQARAMTQRLGNGAMTQALDRAIGE LGSSKTISLGTAKTLKIGAKTQTLSSDAALPSDEDIRRMTG Deinococcus radiodurans NYSGXRC-2839e SGX Pharmaceuticals 2003-09-30 active Selected Cloned Expressed Soluble sp|P31465|YIEF_ECOLI GENBANK NP_294347.1 AARGFRAGADHLRHQFCPPLVDPHRPWTARMKLLALSGSLRADSVNTALLRALAEAAPAGVEVCFFDGLRDLPLFN PDAEERENAAVTAWRAALRGADAVVISSPEYAHGIPGAFKNALDWVVGSAEFDGKPTLLLCASARPQHAPAQLAE VLRTMGARVQGPHLLDLPGNVAAAQSALRTPAQQAEARELL Deinococcus radiodurans NYSGXRC-2839g SGX Pharmaceuticals 2001-03-12 active Selected Cloned Expressed Soluble sp|P31465|YIEF_ECOLI GENBANK NP_388815.1 NMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNGEAEQSELLKVQELKQRVTKADAIVLLSPEYHSG MSGALKNALDFLSSEQFKYKPVALLAVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENI KESIKELVEELSMFAKAGNPGV Bacillus subtilis NYSGXRC-2840d SGX Pharmaceuticals 2003-08-07 active Selected Cloned Expressed Soluble Purified pir||S56560 ICEDB: T1474 GENBANK NP_070781.1 NVGYLCTYTPKELIDAAGFTPIRIFAGDMQISLATAHIQSYACSQARGSLERALRGELDVQAVVFTRCCDTLMRLA DIWERNTDMRVYNIEFPTRVEERSKDYYFNELKDFVKVLEEWGGGVTLESLRESLKLYHELEEKLKRLFSLKPDY EAAKRVQEMNVREAIKFVDERLRKAESEGGKPRVLITGSVCPFVEVYTLFEEAGFALKDDICTGTRFFTFNTPPR EIGSVDEGLRFLVDKYFEKAPCPTKHFPNDDRFKYILEMAKDCDGVVFLLLKFCEPHFYDYPQLKERLEEMGKKV LLLELEFPIASIEQLRTRIEAFYEVIA Archaeoglobus fulgidus NYSGXRC-2845g SGX Pharmaceuticals 2003-08-13 active Selected Cloned Expressed Soluble Purified gb|AAG07850.1|AE004860_6 ICEDB: T1473 GENBANK NP_391300.1 DMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLENPLIERKETDTPPLSYHKTNKNRMNAQEAGLQLS NPQKTLQDALKQQSLDMNLTNTEKKIFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGA RSLQECILLQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPGLLFARPEQD VYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSYLSAKYQEWRWLSRALRQRKQTITRII NELITRQKDFFLKGRSAMKPLTLREVADCLSLHESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYA VKTHLENLINQEDKTKPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK Bacillus subtilis NYSGXRC-2846c SGX Pharmaceuticals 2003-11-07 active Selected Cloned Expressed Soluble Purified sp|P44062|YGFE_HAEIN ICEDB: T1600 GENBANK NP_232107.1 SNQAVDIEILGKVTRVNCPAGQEASLLQAAQDLDNRLKEMAERTKVTNEVKLLTIAALNICYELQTKQQENAGTQS QLSERMEQLAASLEAALKNVKPGKQ Vibrio cholerae NYSGXRC-2848c SGX Pharmaceuticals 2003-07-11 active Selected Cloned Expressed Soluble Purified gb|AAG06018.1|AE004691_9 ICEDB: T1525 GENBANK NP_251320.1 NADTPLQLLGGLTAAEFLRDYWQRKPLLVRQAIPDFESPLSADELAGLSLEESVESRIVLEHGKTPWEMRRGPFQE EDYQHLPEQDWTLLVQAVDQFVPEVAQLLEQFRFLPSWRIDDVMISYAAPGGGVGPHFDNYDVFLLQGHGRRRWK VGQMCSSDSPLREHADLRILADFEQSDEWVLEPGDMLYLPPRLAHYGIAEDECMTYSIGFRAPSAAEVLTHFTDF LGQFLSDEERYTDAGLQPVGDDPHQIQRDALERLQGLIQEHMSDERLLLTWFGQFMTEPRYPELVAGEEIPEEEL FGALEDGALLVRNPSARLAWSEIDIGLVLFASGQSVLLPGQLKELLKLVCSADALHLENLGQWLADDDARKLLAE LVKQGSLEFADE Pseudomonas aeruginosa NYSGXRC-2848d SGX Pharmaceuticals 2003-07-25 active Selected Cloned Expressed Soluble Purified gb|AAG06018.1|AE004691_9 ICEDB: T1610 GENBANK NP_438558.1 TALSSVDFCLPEHITPEIFLRDYWQKKPLVIRNGLPEIVGQFEPQDIIELAQNEDVTARLVKTFSDDDWKVFFSPL SEKDFQKLPEKWSVLVQNLEQWSPELGQLWNKFGFIPQWQRDDIMVSYAPKGGSVGKHYDEYDVFLVQGYGHRRW QVGKWCDASTEFKPNQSIRIFDDMGELVIDEVMNPGDILYIPARMAHYGVAEDDCLTFSFGLRYPNLSNLIDGIS KGFCHQDPDLNLSEFDLPLRLSQSEQRTGKLADENIQAMKQLLLDKLAHSEAFDTLFKQAVASAVSSRRYELLVS DEMCDPDEVRSILEEDGAFLSQDNNCKLLYTENPLRIYANGEWLDELNIIESEVLKRLSDGESLDWAFLSDLANK TEDPETSMDLLLDSICNWVDDGWALIE Haemophilus influenzae NYSGXRC-2850e SGX Pharmaceuticals 2004-04-06 active Selected Cloned Expressed Soluble Purified pir||S61299 ICEDB: T1601 GENBANK NP_439262.1 NILIIGPSWVGDMMMSHSLYQQLKIQYPNCNIDVMAPNWCKPLLARMPEVRKAIEMPLGHGAFELGTRYRLGKSLR EQYDMAIVLPNSLKSAFIPFFAKIVHRRGWKGESRYILLNDLRANKKDYPMMVQRYVALAFEKDVIPKADDIPVL KPYLTVEPAQQAETLKKFEKQTALLGERPIIGFCPGAEFGPAKRWPHYHYAKLAEMLITQGYAVALFGSAKDEPV GEEIRQALPEELREFCVNLAGKTNLNEAVDLIANCTAVVTNDSGLMHIAAAVNRPLIALYGPTSPQYTPPLSDKA TIIRLIEGELIKVRKGDKEGGYHQSLIDITPEMALEKLNELLAK Haemophilus influenzae NYSGXRC-2851c SGX Pharmaceuticals 2003-08-18 active Selected Cloned Expressed Soluble gb|AAB53417.1| GENBANK NP_459543.1 ILRRVFIAIGCVLFSPLSQANSSLGEVNIELRGNVVDFTCAVVAGDSNKSVNLGTWPTKQLHAAGDATQPVAFSLK LEGCPPGSASITFSGTPAPGTALLALADTAMAQKLAIEIRDGDQRRLPLEQASKAVDIDNNGNATLKFYANYIAL ADGVQPGLANADATFLINYN Salmonella typhimurium NYSGXRC-2861c SGX Pharmaceuticals 2003-09-08 active Selected Cloned Expressed Soluble sp|P44685|ICC_HAEIN GENBANK NP_232063.1 KVSSQSEDSSIKLIQITDTHLFAAEDGSLLSVNTADSFAAVVAAIGEEQVEFDAILATGDISQDHTPESYQRFVRG IQPLKKACYWLPGNHDYKPSMHSVLPTQQIQAVEHVLLGEHWQVVLLDSQVVGVPHGKLSEQQLQLLDNKLTEYP ERHTLVLLHHHPLLVGSAWLDQHTLKESERFWDVVAKHSNVKAILCGHVHQDMDRIHLGARVMATPSTCVQFKPN SQDFALDNCSPGWRELTLHADGQVSTQVKRLKQGRFLPDFNSNGY Vibrio cholerae NYSGXRC-2861d SGX Pharmaceuticals 2003-07-22 active Selected Cloned Expressed Soluble Purified sp|P44685|ICC_HAEIN ICEDB: T1578 GENBANK NP_438561.1 KNTFVYQAEKPVIKLLQITDPHLFKDESAELLGVNTQASFAQVLKEIQQENNEFDVILATGDLVQDSSDEGYIRFV EMMKPFNKPVFWIPGNHDFQPKMAEFLNQPPMNAAKHLLLGEHWQALLLDSQVYGVPHGQLSQHQLDLLKETLGK NPERYTLVVLHHHLLPTNSAWLDQHNLRNSHELAEVLAPFTNVKAILYGHIHQEVNSEWNGYQVMATPATCIQFK PDCQYFSLDTLQPGWREIELHSDGSIRTEVKRIQQAEFFPNMQEEGY Haemophilus influenzae NYSGXRC-2861e SGX Pharmaceuticals 2003-09-26 active Selected Cloned Expressed Soluble Purified sp|P44685|ICC_HAEIN GENBANK NP_253656.1 SRHSNTPATDASVLLVQLSDSHLFAEDGARLLGMDTAHSLEKVVERVAREQPRIDLILATGDVSQDGSLDSYTRFR RLSAPLDAPLRWFAGNHDEREPMQRATEGSDLLEQVVDVGNWRVVLLDSSIPGAVPGYLEEDQLELLRRAIDSAG ERFLLVSFHHHPVPIGSDWMDPIGLRNPQALFDLLAPYPQVRCLLWGHIHQEFDRQRGPLRLLASPSTCVQFAPG SSDFTLDRLAPGYRWLRLHDDGRLETGISRVDDVVFEVDYDTAGY Pseudomonas aeruginosa NYSGXRC-2862c SGX Pharmaceuticals 2003-08-17 active Selected Cloned Expressed Soluble sp|P33129|HTRE_ECOLI GENBANK NP_459201.1 AHYKKFRLSTLAAVVGIVLAVGPENSYAEAPIQFNTRFLDVKDDASLDLSRFSRKGYIMPGSYHLQVLVNQSQIVQ DNVITYSVDNNDPDNTYPCLSPELVSLLGLKPEIADKMIWINAGQCLQPDQLEGMETQTDLSQSTLTVIIPQAYL EYSDEEWDPPSRWDEGIPGVLFDYNVNSQWRHAEHDDGDEYDISGNGTVGANLGAWRLRADWQANYRHENDSEDK DNFGSSSEQNWDWNRYYAWRAIPQLRAQLTLGEGSLESDIFDGFNYVGGSLITDDQMLPPNLRGYAPDISGVART NAKVTVTQRGRVIYESQVPAGPFRIQDINETVSGDLHVKIEEQSGQVQEYDVSTASIPFLTRPGQVRYKLAAGRP QDWDHNMEGGFFTSAEASWGIANGWSLYGGAIGEQDYQALALGLGRDLALLGAFSVDVTHSRATLPEGSAYGDGT IQGNSFRASYAKDFDDIDSRLTFAGYRFSEENYMTMDEFIDTHNDDNDRQRTGHDKEMYTLTYSQNFSAINVNAY INYTHRTYWNQPNQDSYNLTLSHYFDVGEVRGISLSVNGFRNEYDNERDDGVYVSLSIPWGNNRTLSYNGSFSDD NNSNQVGYYERIDDRNNYQINAGRADNGATLDGYYRYQASYADIDVSANYQEGDYTSGGLNIQGGATLTAKGGAL HRTSVNGGSRLLVDVGDEANVPISGYSTPVYTNAFGKAVIVDVNDYYRNQVKIDITQLPEDAEAILSIAQATLTE GAIGYRRMEVLSGKKAMASIRLRDGGTPPFGAEVYNSRQQQLGIVGEDGSVYLIGINPGERLQVTWEGKTQCEAT LPDPLPGDLFSGLLLPCIGDASSPEATQPEEKPLLQLHTQRRTSSTQPEALSSRYPTH Salmonella typhimurium NYSGXRC-2864c SGX Pharmaceuticals 2003-10-15 active Selected Cloned Expressed Soluble Purified gb|AAG04696.1|AE004560_4 ICEDB: T1579 GENBANK NP_231860.1 CELLGMSANVPTDICFSFTGLMQRGGKTGPHRDGWGIAFYEGKGFRTFKDPNPSSQSKIAELVQQYPIKSRAVISH IRQANRGGVNLENTHPFTRELWGQYWTFAHNGQLTGYQNLVTGRHRPVGETDSELAFCWLLNQMEQCYPEGPQDW PEMLRYVAQCCDELRALGVFNMLLSNGEYVMAYCTNHLYWITRRAPFGCAALLDEDVEINFQEETTPNDVVSVIA TQPLTGNETWQRMKPGQFAFFHFGERIEDNAHVLMDVGFAPNRPGCQAPSQPLD Vibrio cholerae NYSGXRC-2864f SGX Pharmaceuticals 2001-11-20 active Selected Cloned Expressed Soluble Purified gb|AAG04696.1|AE004560_4 ICEDB: T799 GENBANK NP_274812.1 CQLLGMNCNTPTDIMFSFEGFRRRGGITDHHADGFGIGFFEGKGVRLFHDDKPSVNSPVADLVRAYQIKSENVIAH IRKASQGQTSLANTHPFMREMWGGYWLFAHNGHLIDFFPEQGEFFHPVGTTDSERAFCHILNRLRTRFAARPDDD TLFDAIAGLTHEIRKFGLFNFMLSDGIALFAHASTLLHYIVRQAPFGKARLLDDDVMVDFAEVTTPSDRVAVIAT LPLTRDESWSQLAVDELVMFREGNIVRHDRPENPVYMSAEEGLEIARA Neisseria meningitidis NYSGXRC-2869a SGX Pharmaceuticals 2001-12-04 active Selected Cloned Expressed Soluble Purified sp|P39298|YJFP_ECOLI ICEDB: T1412 GENBANK NP_418611.1 IEIESRELADIPVLHAYPVGQKDTPLPCVIFYHGFTSSSLVYSYFAVALAQAGLRVIMPDAPDHGSRFSGDAARRL NQFWQILLQSMQEFTTLRAAIAEENWLLDDRLAVGGASMGAMTALGITARHPTVRCTASMMGSGYFTSLARSLFP PLIPETAAQQNEFNNIVAPLAEWEATNHLEQLSDRPLLLWHGLDDDVVPADESLRLQQALSETGRDKLLTCSWQP GVRHRITPEALDAAVTFFRQHL Escherichia coli NYSGXRC-2869c SGX Pharmaceuticals 2003-10-09 active Selected Cloned Expressed Soluble Purified sp|P39298|YJFP_ECOLI ICEDB: T1548 GENBANK NP_388996.1 IQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNLHIAYLLAEKGFRAVLPEALHHGERGEEMAVEEL AGHFWDIVLNEIEEIGVLKNHFEKEGLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQI DHIQSQGIEIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKSHYSEQPERL QFIGDENADHKVPRAAVLKTIEWFETYL Bacillus subtilis NYSGXRC-2873c SGX Pharmaceuticals 2003-10-02 active Selected Cloned Expressed Soluble Purified sp|P40676|SLYA_SALTY ICEDB: T1552, T1644 GENBANK NP_456086.1 KLESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGL ISRQTCASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISSEEIELLIKLIAKLEHNIMELHSHD Salmonella typhimurium NYSGXRC-2877c SGX Pharmaceuticals 2003-08-15 active Selected Cloned Expressed Soluble gb|AAG06840.1|AE004766_1 GENBANK NP_252142.1 KILLMLLCVSVLGCSKNSVESEKPVDVLLIGGGIMSATLGTYLNELEPGWTIEMVERLDKVAEESSNGWNNAGTGH SAFCELNYTSEAADGSMDISKAVAINENFEISKQFWAYQVDRKVLNDPKSFINNVPHMSFVWGDDNVAFLKKRHA ALQHSSLFRGMEYSEDPEQIKQWVPLVMEGREPGQKIAATRMSIGTDVNFGEITRQLVGSLSAKDTFKLRLQHEV RDLKRNDDNTWTVTMADLANGDKETSVKARFVFIGAGGGALKLLQMSGIPEAEGYAGFPVGGSFLATTNPDVVKR HLAKVYGKASVGSPPMSVPHLDTRMIDGKPVLLFGPFATFSTKFLKNGSLWDLPGSVTSGNIGPMFNAGIDNFDL SQYLIGQLMLSQDDRMASLREYFPEARDEDWKLVQAGQRVQIIKKDAEKGGVLQFGTEVVTAADGSVAALLGASP GASTAAPIMLSVLEKAFKDKVATPEWQARLKEIVPSYGRKLNNDIELTNSTRAWSSERLQLIHVPVQ Pseudomonas aeruginosa NYSGXRC-2877d SGX Pharmaceuticals 2003-08-18 active Selected Cloned Expressed Soluble Purified gb|AAG06840.1|AE004766_1 ICEDB: T1553, T1645 GENBANK NP_253330.1 AQNDHETVDMLLVGAGIMSATLAVLLKELDPNLKMEVVELQESGAIESSNPWNNAGTGHAGLCELNYTPQSADGSI DIKKAVGINTMFEVSKQFWSHLVAKGTFGSPKTFINPVPHLSFVRGSEGIAYLKKRFESLTKHHAFETMVYSEDK ATLAEWMPLMMPGRPADEAIAATRVEGGTDVNFGALTNQLLQHLAQQPGAQIRYNQKVTHLRRADNGWRVTVKDT RNGGDREIQARFVFLGAGGGALPLLQLSGIPEGKGFGGFPVSGQWLRCDNPEIVKQHQAKVYSQAEVGSPPMSVP HLDTRVVDGKKSLLFGPYAGFSTKFLRHGSFLDLPLSVRPGNILPMLSVARDNMDLTRYLIGQVMQSPEQRLEAL RKFYPEARAEDWRLEVAGQRVQIIKKDPKKGGILQFGTELVAAHDGSIAALLGASPGASVTVSIMLGLIERCFPE QARSPEWSAKLKEIFPAREKELESDAELYRSVSSRCSEVLELTAKNDVQA Pseudomonas aeruginosa NYSGXRC-2878c SGX Pharmaceuticals 2003-08-17 active Selected Cloned Expressed Soluble gb|AAG08055.1|AE004880_11 GENBANK NP_460734.1 TLPDFRLIRLLPLASLVLTACTLPGHKGPGKSPDSPQWRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTG QDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLD DQYRLSEVNYRQDGKNWKVVYGGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK Salmonella typhimurium NYSGXRC-2878e SGX Pharmaceuticals 2003-07-23 active Selected Cloned Expressed Soluble gb|AAG08055.1|AE004880_11 GENBANK NP_439749.1 NMKTFKFFTALFATAILTACTLDMERPTNVQYIDKTDAIWQQHLQKIQKIQSYQAKGQIGYISPTERFSSRFEWQY QNPKSYTLKLYSLISKSTLWIQMHQSGMTISDNNGNQQSAANSKLLLQEIIGMDVPLEHLAYWLKGQPAMNADYQ VGTNHLLGAFTYHVDGSQWTADYLTYHSNNSMPENILLKNDSTKQTLKIRVDEWIY Haemophilus influenzae NYSGXRC-2880c SGX Pharmaceuticals 2003-10-02 active Selected Cloned Expressed Soluble Purified gb|AAG07865.1|AE004861_6 ICEDB: T1611 GENBANK NP_230073.1 SAELLLNVTPSETRVAMIEGGILQEIHIEREAKRGIVGNIYKGKVSRVLPGMQAAFVDIGLDKAAFLHASDIVPHT ECVAESEKQQFQVRDISELVRQGQDIVVQVVKDPLGTKGARLTTDITLPSRYLVFMPGASHVGVSQRIESEAERE RLKKIVSHYCDEHGGFIIRTAAEGANEKELTQDAAFLKRLWSKVIERRSKYKNRSMLYGELGLAQRILRDFVGTE LTKILIDSRQEFENLKEFTSEYVPELTAKLELYHGDKPIFDMYDTENEIQRSLERKVELKSGGYLIIDQTEAMTT IDINTGAFVGRRNLEETIFNTNIEATQAIARQLRLRNLGGIIIIDFIDMASDEHRKRVLTSLETALMKDRVKTNI NGFTQLGLVEMTRKRTRESIEHVLCSTCPTCEGRGSVKTVETVCFEILREITRVNRAYDADKFVVYASPAVADTL QGEESHALAELEVFIGKEVRIQAEPLYNQEQFDVVMM Vibrio cholerae NYSGXRC-2880e SGX Pharmaceuticals 2003-08-18 active Selected Cloned Expressed Soluble Purified gb|AAG07865.1|AE004861_6 ICEDB: T1612 GENBANK NP_253167.1 SEEILINITPMESRVAVVENGVLQEVHVERTQRRGIVGNIYKGRVVRVLPGMQAAFVDIGLERAAFIHAAEISNRE GSAVESISALVHEGQALVVQVTKDPIGTKGARLTTHLSIPSRYLVYMPRTSHVGISLRIEDEVERERLKKVVADC VAAEGIEGQGGFILRTAAEGAGEDEILADIRYLRRLWDQIAAQIQTVGAPSVIYEDLSLAIRTLRDLVNPRIEKI RIDSRENFQKITSFVEELMPEISDRLEHYPGERPIFDLYGVEDEIQKALERKVLLKSGGYLIVDPTEAMTTIDVN TGAFVGHRNLEETIFKTNLEAATAIARQLRLRNLGGIIIIDFIDMEDEEHRRQVLRTLEKQLERDHAKTNIIGIT ELGLVQMTRKRTRESLVQILCEPCPCCQGRGMLKTAETTCYEIFREILREARAYQADSYLVLANQKVVDRLLDEE SGNVADLEAFIGRTIKFQVEAMYSQEQYDVVLL Pseudomonas aeruginosa NYSGXRC-2887c SGX Pharmaceuticals 2003-08-19 active Selected Cloned Expressed Soluble Purified gb|AAG04326.1|AE004528_4 GENBANK NP_249628.1 SMSLRDQLLKAGLVNEKQAKQATKQKQKQQRLEHKNQVDKDDSQRQAAEQAKAEKLARDQELNRQQQEKAEKKAKA AQIKQLIEGTRLPKLESDDYYNFVDAKKVKRIAVNDLIRDKLSRGSLAIVSYDGRYEIVPRDAAVKIQERDPRRV VLLNVQSQEPDEDDPYKDYVVPDDLMW Pseudomonas aeruginosa NYSGXRC-2889f SGX Pharmaceuticals 2003-08-08 active Selected Cloned Expressed Soluble gb|AAG08022.1|AE004877_9 GENBANK NP_389747.1 CGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAIINDGSNNRLGKLRWGLIPPWAKDEKIGYKMINA RAETITEKPAFRRPLVSKRCIIPADSFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIIT TEPNEFMKDIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSAELLDAENHM Bacillus subtilis NYSGXRC-2889h SGX Pharmaceuticals 2003-08-15 active Selected Cloned Expressed Soluble gb|AAG08022.1|AE004877_9 GENBANK NP_253324.1 SGRYALFRWNPSLAALPGFPADWRAQWNISPANQVLMVREDAGARRADLARWGLTPAWLTDLSRTPSHARAETLAE QPMFREAFQQRRCLLPANGFYEWRGVRKRPYWVSTGERLLFFAGIWEAYPVHGQTWLSVAQVSQAAAEFRRPLLL DEAEQDTWLAPDTPLPALISLLAKPQPNLRSVALAGFVNKPETDGPE Pseudomonas aeruginosa NYSGXRC-2890e SGX Pharmaceuticals 2003-08-15 active Selected Cloned Expressed Soluble sp|P44553|YFIO_HAEIN GENBANK NP_253235.1 QVKHLLLIAILALTAACSSNKETVDENLSESQLYQQAQDDLNNKSYNSAVTKLKALESRYPFGRYAEQAQLELIYA NYKNMEPEAARAAAERFIRLHPQHPNVDYAYYLKGLSSFDQDRGLLARFLPLDMTKRDPGAARDSFNEFAQLTSR FPNSRYAPDAKARMVYLRNLLAAYEVHVGHYYLKRQAYVAAANRGRYVVENFQETPAVGDGLAIMVEAYRRLGLD DLASTSLETLKLNYPDNASLKDGEFVARESEADTRSWLAKATLGLIEGGEPPPHMETQAAKDVIKQYEDAEREIP AELKPENQDHSADDEKPESDDDEDSGRSWWSYMTFGLFD Pseudomonas aeruginosa NYSGXRC-2892a SGX Pharmaceuticals 2003-11-24 active Selected Cloned Expressed Soluble gb|AAF96476.1| GENBANK NP_417079.1 SQRGLEALLRPKSIAVIGASMKPNRAGYLMMRNLLAGGFNGPVLPVTPAWKAVLGVLAWPDIASLPFTPDLAVLCT NASRNLALLEELGEKGCKTCIILSAPASQHEDLRACALRHNMRLLGPNSLGLLAPWQGLNASFSPVPIKRGKLAF ISQSAAVSNTILDWAQQRKMGFSYFIALGDSLDIDVDELLDYLARDSKTSAILLYLEQLSDARRFVSAARSASRN KPILVIKSGRSPAAQRLLNTTAGMDPAWDAAIQRAGLLRVQDTHELFSAVETLSHMRPLRGDRLMIISNGAAPAA LALDALWSRNGKLATLSEETCQKLRDALPEHVAISNPLDLRDDASSEHYIKTLDILLHSQDFDALMVIHSPSAAA PATESAQVLIEAVKHHPRSKYVSLLTNWCGEHSSQEARRLFSEAGLPTYRTPEGTITAFMHMVEYRRNQKQLRET PALPSNLTSNTAEAHLLLQQAIAEGATSLDTHEVQPILQAYGMNTLPTWIASDSTEAVHIAEQIGYPVALKLRSP DIPHKSEVQGVMLYLRTANEVQQAANAIFDRVKMAWPQARVHGLLVQSMANRAGAQELRVVVEHDPVFGPLIMLG EGGVEWRPEDQAVVALPPLNMNLARYLVIQGIKSKKIRARSALRPLDVAGLSQLLVQVSNLIVDCPEIQRLDIHP LLASGSEFTALDVTLDISPFEGDNESRLAVRPYPHQLEEWVELKNGERCLFRPILPEDEPQLQQFISRVTKEDLY YRYFSEINEFTHEDLANMTQIDYDREMAFVAVRRIDQTEEILGVTRAISDPDNIDAEFAVLVRSDLKGLGLGRRL MEKLITYTRDHGLQRLNGITMPNNRGMVALARKLGFNVDIQLEEGIVGLTLNLAQREES Escherichia coli NYSGXRC-2893d SGX Pharmaceuticals 2003-08-17 active Selected Cloned Expressed Soluble sp|P43662|LPFC_SALTY GENBANK AAA75419.1 KKTTWFAGRFPGYVSPLSSVALSVLAALCPLTSRGESYFNPAFLSADTASVADLSRFEKGNHQPPGIYRVDIWRND EFVATQDIRFEAGAVGTGDKSGGLMPCFTPEWIKRLGVNTAAFPVSDKGVDTTCIHLPEKIPGAEVAFDFASMRL NISLPQASLLNSARGYIPPEEWDEGIPAALINYSFTGSRGTDSDSYFLSLLSGLNYGPWRLRNNGAWNYSKGDGY HSQRWNNIGTWVQRAIIPLKSELVMGDSNTGNDVFDSFGFRGARLYSSDNMYPDSLQGYAPTVRGIARTAAKLTI RQNGYVIYQSYVSPGAFAITDLNPTSSSGDLEVTVDEKDGSQQRYTVPYSTVPLLQREARVKYDLVAGDFRSGNS QQSSPFFFQGTVIAGLPAGLTAYGGTQLADRYRAVVVGAGRNLGDWGAVSVDVTHARSQLADDSTHQGQSLRFLY AKSLNNYGTNFQLLGYRYSTRGFYTLDDVAYRSMEGYDYEYDSDGRRHKVPVAQSYHNLRYSKKGRFQVNISQNL GDYGSLYLSGSQQNYWNTADTNTWYQLGYASGWQGISYSLSWSWSESVGSSGADRILAFNMSVPFSVLTGRRYAR DTILDRTYATFNANRNRDGDNSWQTGVGGTLLEGRNLSYSVTQGRSSSNGYSGSASASWQATYGTLGVGYNYDRD QHDYNWQLSGGVVGHADGITFSQPLGDTNVLIKAPGAKGVRIENQTGVKTDWRGYAVMPYATVYRYNRVALDTNT MDNHTDVENNVSSVVPTEGALVRAAFDTRIGVRAIITARLGGRPLPFGAIVRETASGITSMVGDDGQIYLSGLPL KGELFIQWGEGKNARCIAPYALAEDSLKQAITIASATCIRPAS Salmonella typhimurium NYSGXRC-2893f SGX Pharmaceuticals 2003-10-13 active Selected Cloned Expressed Soluble sp|P43662|LPFC_SALTY GENBANK AAD34372.1 RNQLFMTRYYSSVTKPVLTPLALAIALAPAPGWAENYFNPAFLSDDPSAVADLSTFSRNAQAAGMYRVDVYLNNTF LATRDIAFQAVKTTGKSAPTDDSGLRACLTPEMLKNMGVNTGAFPLLAKAAAGSCPDLASAIPAARTRFDFAQQR LDISIPQAAMVASARGYIPPKYWDEGINALLLNYTFTGANSQDRSPGGSAENSYFLGLNNGLNLGAWRLPDYSTW NANSGDQNSDSDWQHISTYLERDVVFLQGELTAGDIIPPPHYRQLPFRRLQLASDDNMLPDSMKGFAPTIHGIAR SNAQVTIRQNGYIINQRYVPPGAFTINDLYPTAASGDLTVEVKESDGSINRYNVPYSAVPILQREGRLKYAATVA EYRSDSSQKEKVKFGQATLIWGLPHGFTLYGGTQLSSHYHALAIGSGANLGDWGAVSLDVTQATSTLADNNTYQG QSLRFLYAKSLAQSGTNLQLMGYRYSTSGFYTLDDTTWKRMSGYDDDSRTDSDKSRPEWADYYNLYYTRRGKYNS IQSTARRVGIAFITGSQQSYWHTDEKDSLLQVGYSDTLAGIAWSVSYNNNKSAGDAERDQIFALIFGAVSQWLQH GDEVTRHHNVYATFSTSTDKQHNVTQNAGLSGTLLDENNLSYNIQQGYQNHGIGESGAASLEYDGAKGNANIGYN VSDNGDYQQVNYGLSGGLVAHAHGVTLSQPLGNTNILIAAPGAANVGVVDQPGIHTDARGYAVVPYATTYRQNRM ALDVNAMADDVDIDDAVTRVVPTEGALVLARFKARVGARALVTLNHNGKPVPFGATVTVNDRHAEAIVDEAGEVY LSGLSAQGVLHVRWGNLPDQQCVASYHLSSSRQILSRQHAECH Salmonella typhimurium NYSGXRC-2893h SGX Pharmaceuticals 2003-08-19 active Selected Cloned Expressed Soluble sp|P43662|LPFC_SALTY GENBANK AAA73968.1 TWTHLPLGNKTSRFTQSALALMIAGTLPAYAGTFNPRFLEDVPGIDQHVDLSMYESNKAEHLPGKYRVSVVVNEKK MESRTLEFKAATEAQRAKMGESLVPCLSRVQLEDMGVRIDSFPALKMAPPEACVAFDDIIPQAASHFDFADQTLI MSFPQAAMKQTARGTVPESQWDEGVNALLVDYNFSGSNASYDAHDSETSYNSDSYYLNLRSGMNLGAWRLRNYST WTRNDGNNTWDNIGTSLSRAIVPLKSQLTLGDTSTAGDIFDSVQMRGVQLTSDEEMLPDSQRGFAPVIRGIAKSN AEVTVEQNNYVIYRTFVQPGAFEINDLYPTSNSGDLTVTIKESDGSEQKFVQPFSSVALLQREGHLKYSLSAGEY RAGNYNSAEPKFGQLDAMYGLPYGFTVYGGAIFSDDYYSLAGGLGKNFGYIGAISIDVTQAKSKLANEENSEGQS YRFLYSKSFNSGTDFRLLGYKYSTSGYYTFQEATDVRTDADSSYSQYHKRSQIQGNVTQQLGAWGSVYFNVTQQD YWNDEGKQRSLNAGYNGRIGRVNYSVAYTWTKSPEWDESDRLLSFSMSIPLGRVWSNYHLTTDQHGRTNQQLGVS GTALEDHNLNYSVQEGYGSNGVGNSGSVNLDYQGGVGSASLGYNHNRDGQQVELRFGGGVIAHSEGITLSQPLGE SMAIISAPGARARHVINNGGVEVDWMGNAVVPYLTPYRETEVSLRSDSLNNQVDLDTASVNVVPTRGAIVRARFD TRVGYRVLMNLTQANGKAVPFGATATLLDTTKESSSIVGEDGQLYISGMRQKGALQVNWGKDQAQQCRVAFTLPE QQDNTGVVMANAVC Salmonella typhimurium NYSGXRC-2896c SGX Pharmaceuticals 2006-06-21 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB gb|AAG07216.1|AE004800_5 ICEDB: T2196 GENBANK NP_250908.1 PDB 2HDW PFAM PF01738 ETKHSNRARSRKGALRGAVLAGALMALVGCQTSPAATTSSNTGGTNMQLQLTQEWDKTFPLSAKVEHRKVTFANRY GITLAADLYLPKNRGGDRLPAIVIGGPFGAVKEQSSGLYAQTMAERGFVTLAFDPSYTGESGGQPRNVASPDINT EDFSAAVDFISLLPEVNRERIGVIGICGWGGMALNAVAVDKRVKAVVTSTMYDMTRVMSKGYNDSVTLEQRTRTL EQLGQQRWKDAESGTPAYQPPYNELKGGEAQFLVDYHDYYMTPRGYHPRAVNSGNAWTMTTPLSFMNMPILTYIK EISPRPILLIHGERAHSRYFSETAYAAAAEPKELLIVPGASHVDLYDRLDRIPFDRIAGFFDEHL Pseudomonas aeruginosa NYSGXRC-2896d SGX Pharmaceuticals 2003-10-16 active Selected Cloned Expressed Soluble gb|AAG07216.1|AE004800_5 GENBANK NP_252518.1 QRLNVEFRSEGVALRGWLYLPEARAERPAIVMTHGFSGVKEQYLDRYAEVFAAAGFVVLLYDHPNFGDSDGEPRQE IDPVMQRRGYRDAITWLGAQARVDASRIGIWGTSYSGGHVLEVAALDRRVKCVVAQVPTVSGHASALRRTRAEQL PALLASFDADRQRRFEGLPPALLPAVAASPDEPCAMAGADAHRFFTDSAALAPNWCNRVTLRSAELARENEPGIH IGRISPTPLLMIVADRDLLTPTDLCLEAYQRALPPKRLLMLAGGHFTPYIEHFDATSQAAADWFVRHLGEGGEQP ATVVE Pseudomonas aeruginosa NYSGXRC-2897c SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble Purified pir||C75500 ICEDB: T1554 GENBANK NP_294310.1 TVPDFQAFMRPMLEQISSGEPQKIAELYRRLAEFFALTPQDTEELLPSGKQAKYHNRILWAKFHLDRAGVLTTPSR GVVQITPLGREFLSRYPEHIGMRELQTIPAYAEFTRRSRSPAQSPAPAAPPQAECSASVPPAEQIDALYAELTAN LAEELLAQVKELSPAQFERLVVEVLVAMGYGGSVRDAGQALGRSGDNGIDGLIKQDPLGLDRIYLQAKRWKNTVH SPEIRTFSGSLTYHKATKGVFITTSGFSDGAKATAGQIGNIILLDGETLAHLMIEYGVGVLTRETYQIRRLDADY FEEL Deinococcus radiodurans NYSGXRC-2903c SGX Pharmaceuticals 2003-08-19 active Selected Cloned Expressed Soluble sp|P43758|DKSA_HAEIN GENBANK NP_454802.1 QEGQNRKTSSLSILAIAGVEPYQEKPGEEYMNEAQLSHFKRILEAWRNQLRDEVDRTVTHMQDEAANFPDPVDRAA QEEEFSLELRNRDRERKLIKKIEKTLKKVEDEDFGYCESCGVEIGIRRLEARPTADLCIDCKTLAEIREKQMAG Salmonella typhimurium NYSGXRC-2903e SGX Pharmaceuticals 2003-07-25 active Selected Cloned Expressed Soluble Purified sp|P43758|DKSA_HAEIN ICEDB: T1797 GENBANK NP_438235.1 SRASLSLLDLAGVKPYQMKKDEEYMNEEQILHFRKILNAWHEQIVEEASRTVAHMQDEVTNFPDPADRATQEEEFS LELRNRDRERKLMKKIEATLKKLDTDDFGYCDCCGEEIGIRRLEARPTADLCIDCKTLAEIREKQVAG Haemophilus influenzae NYSGXRC-2903f SGX Pharmaceuticals 2003-08-19 active Selected Cloned Expressed Soluble Purified sp|P43758|DKSA_HAEIN ICEDB: T1613, T1614 GENBANK NP_253411.1 STKAKQQSSQQMTRGFEPYQETKGEEYMSERMRAHFTAILNKWKQELMEEVDRTVHHMQDEAANFPDPADRASQEE EFSLELRARDRERKLIKKIDETLQLIEDEEYGWCDSCGVEIGIRRLEARPTATLCIDCKTLAEIREKQLGS Pseudomonas aeruginosa NYSGXRC-2903h SGX Pharmaceuticals 2003-08-19 active Selected Cloned Expressed Soluble Purified sp|P43758|DKSA_HAEIN ICEDB: T1615 GENBANK NP_254223.1 TEQELLAQPDAAYMDEAQQDFFRDLLLRQRQELQARIEGEFGELRDLERPSDEADLASREEQRQWQLRLLEREKKL LDKIDEALERLARGDYGWCQETGEPIGLRRLLLRPTATLCIEAKERQEKRERHVRHN Pseudomonas aeruginosa NYSGXRC-2904f SGX Pharmaceuticals 2003-09-25 active Selected Cloned Expressed Soluble Purified gb|AAG07033.1|AE004784_6 ICEDB: T1513 GENBANK NP_252335.1 MDINEIREYLPHRYPFLLVDRVVELDIEGKRIRAYKNVSINEPFFNGHFPEHPIMPGVLIIEAMAQAAGILGFKML DVKPADGTLYYFVGSDKLRFRQPVLPGDQLQLHAKFISVKRSIWKFDCHATVDDKPVCSAEIICAERKL Pseudomonas aeruginosa NYSGXRC-2907e SGX Pharmaceuticals 2001-09-10 active Selected Cloned Expressed Soluble Purified sp|P30849|WRBA_ECOLI ICEDB: T776 GENBANK NP_231797.1 ISIVVLYYSRHGSTQALARQIARGVESVEGCQALLRTVAELDGTASNSDPYLSLDELKQCDGLALGSPVWFGNMAA PLKHFWDQTTPLWLSGALIDKPACVFTSSSTLHGGQETTQQSMMLPLLHHGMLILGIPYSEPALHTTQSGGTPYG ASHVHQQKTLSSEEAELARQLGKRLAHVAKQLKG Vibrio cholerae NYSGXRC-2907g SGX Pharmaceuticals 2003-09-26 active Selected Cloned Expressed Soluble Purified sp|P30849|WRBA_ECOLI GENBANK NP_388783.1 KIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIRKLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYL WAEGELINKVGAVFCTTATTHGGLEMTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSE EGIQLGRALGRRVSQVTGNLTAGQ Bacillus subtilis NYSGXRC-2910a SGX Pharmaceuticals 2003-07-09 active Selected Cloned Expressed Soluble gb|AAG07454.1|AE004822_14 GENBANK NP_415772.1 KKLTVAALAVTTLLSGSAFAHEAGEFFMRAGSATVRPTEGAGGTLGSLGGFSVTNNTQLGLTFTYMATDNIGVELL AATPFRHKIGTRATGDIATVHHLPPTLMAQWYFGDASSKFRPYVGAGINYTTFFDNGFNDHGKEAGLSDLSLKDS WGAAGQVGVDYLINRDWLVNMSVWYMDIDTTANYKLGGAQQHDSVRLDPWVFMFSAGYRF Escherichia coli NYSGXRC-2911a SGX Pharmaceuticals 2003-07-23 active Selected Cloned Expressed Soluble Purified gb|AAG07438.1|AE004821_11 ICEDB: T1475 GENBANK NP_414951.1 ACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADLAYKALAVNLSDLA AMGADPAWLTLALTLPDVDEAWLESFSDSLFDLLNYYDMQLIGGDTTRGPLSMTLGIHGFVPMGRALTRSGAKPG DWIYVTGTPGDSAAGLAILQNRLQVADAKDADYLIKRHLRPSPRILQGQALRDLANSAIDLSDGLISDLGHIVKA SDCGARIDLALLPFSDALSRHVEPEQALRWALSGGEDYELCFTVPELNRGALDVALGHLGVPFTCIGQMTADIEG LCFIRDGEPVTLDWKGYDHFATP Escherichia coli NYSGXRC-2911c SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified gb|AAG07438.1|AE004821_11 ICEDB: T1660 GENBANK NP_459414.1 ACGEFSLIARYFDRVRSSRLDVETGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADLAYKALAVNLSDLA AMGADPAWLTLALTLPEVDEPWLEAFSDSLFALLNYYDMQLIGGDTTRGPLSMTLGIHGYIPAGRALKRSGAKPG DWIYVTGTPGDSAAGLAVLQNRLQVSEETDAHYLIQRHLRPTPRILHGQALRDIASAAIDLSDGLISDLGHIVKA SGCGARVDVDALPKSDAMMRHVDDGQALRWALSGGEDYELCFTVPELNRGALDVAIGQLGVPFTCIGQMSADIEG LNFVRDGMPVTFDWKGYDHFATP Salmonella typhimurium NYSGXRC-2911f SGX Pharmaceuticals 2003-08-19 active Selected Cloned Expressed Soluble Purified gb|AAG07438.1|AE004821_11 ICEDB: T1476 GENBANK NP_252740.1 GEFELIRRFFAAAACAAPAADVALGIGDDCALLAPPAGEQLAVSTDTLVEGVHFPAGCDPFLLAQRALAVSASDLA AMGAAPLAFTLALTLPQADAEWLQGFARGLDAMARQCGLALVGGDTTRGPLSMTLTVFGRVPAGQALTRAGARPG DLLCVGGPLGEAGAALELVLERRSAPAEVAEPLLARYWTPAPQFGLGLALRGKASAALDISDGLLADCGHIARAS GVALLVECQRLQASAALSGLLAGEEALRQQLAAGDDYVLVFTLPPEYLGEIRAAWPAMAVIGRVEAGQGVHLLDA DGKELIPAAAGYQHFGTQRD Pseudomonas aeruginosa NYSGXRC-2911h SGX Pharmaceuticals 2003-08-25 active Selected Cloned Expressed Soluble Purified gb|AAG07438.1|AE004821_11 ICEDB: T1477 GENBANK NP_388471.1 DEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVDTMVEDVHFKLHYSSPEDIGYKALAVNISDIAAM GGIPKFYLVSLAVPSKWTESEIKAMYEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKP NDIVFVTGEIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSDGLASELNEI AEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEEWEVLKQECAALHLPITKIGYVREKTK SKVILKTDQTSMILEKKGYNHF Bacillus subtilis NYSGXRC-2915c SGX Pharmaceuticals 2003-10-15 active Selected Cloned Expressed Soluble Purified gb|AAG07479.1|AE004825_8 ICEDB: T1555 GENBANK NP_252781.1 SQLEPRQQAFRNAMAHLSAAVNVITSNGPAGRCGITATAVCSVTDSPPTLMLCINRNSEMNTVFKANGRLCVNVLS GEHEEVARHFAGMTEVPMERRFALHDWREGLAGLPVLHGALANLQGRIAEVQEIGTHSVLLLELEDIQVLEQGDG LVYFSRSFHRLQCP Pseudomonas aeruginosa NYSGXRC-2915e SGX Pharmaceuticals 2003-12-02 active Selected Cloned Expressed Soluble Purified gb|AAG07479.1|AE004825_8 ICEDB: T1646 GENBANK NP_274839.1 ADLQKNFQTSFRDAMASCAAGVHVITTDGAAGRYGITMTAVAPVTDEPPTVMLCINRSARIIPILSENGSLCINTL ADEHQDVAEHFAGLTGLSPEERFAYHIWHRGKTGQLEIEGALAHLHGHIVGKHEIGTHFVFYVRLDEIKNCGCKR PALLYFRRQFRFLD Neisseria meningitidis NYSGXRC-2917d SGX Pharmaceuticals 2004-12-10 active Selected Cloned Expressed Soluble Purified gb|AAG04952.1|AE004584_8 ICEDB: T1619 GENBANK NP_250254.1 NTLLMHCRPGFEGEVCAEIAEHAATLEIPGYAKSKPASAHVEFVCQDADGAERLMRRLRFADLIFPRQWARGPGFI ELPESQRIEVLLAELASYPVCGSLWLEVLDTNAGKEVSTFCRKFEKPLRAALVKAGRLQEDPALPRLLLTFRSGR EVFVGLAEPRNSALWPMGIPRLKFPREAPSRSTLKLEEAWHQFIPRSEWDKRLAPDMLAVDLGAAPGGWTWQLVN REMRVTAVDNGPMAENLMYSGLVDHQKVDGYQYRPRQRVDWMVCDIVEKPARTGALIETWIGEGLCREAVVNLKL PMKQRYAEVRKILQRLRESFDARGLKVAIGCKQLYHDREEVTCHLRRLER Pseudomonas aeruginosa NYSGXRC-2921c SGX Pharmaceuticals 2003-12-03 active Selected Cloned Expressed Soluble Purified sp|P44325|CDD_HAEIN ICEDB: T1782 GENBANK NP_228774.1 DKLQRISEAIKSKKKLVVMFSGGVDSTLLAKLAREVLGKNAVALTIDSPVIPRKEIEEAKNLANLIGIRHEFIELN ELKSRHLIENPPDRCYLCRKLRDNIVKNWARENGFDVIADGLNFSDLQDYRPGVKASTEDGIWHPFIDFEVTKEE IREYSKKLGLPTWDKPAMACLCSRFPYGFGLNEERVRMVEKAENFLRELGFREVRVRFFPYKTAVVEVGRDEMEL LMGKRTDIVLALQKIGFSFVTLDLEGFASGKLNRTIEGMSK Thermotoga maritima NYSGXRC-2922a SGX Pharmaceuticals 2006-11-16 active Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data gb|AAG05970.1|AE004686_8 ICEDB: T1620 PFAM PF04352 GENBANK NP_274685.1 TQETALGAALKSAVQTMSKKKQTEMIADHIYGKYDVFKRFKPLALGIDQDLIAALPQYDAALIARVLANHCRRPRY LKALARGGKRFDLNNRFKGEVTPEEQAIAQNHPFVQQALQQQSAQAAAETLSVEAEAAESSAAE Neisseria meningitidis NYSGXRC-2922b SGX Pharmaceuticals 2003-11-07 active Selected Cloned Expressed Soluble Purified gb|AAG05970.1|AE004686_8 ICEDB: T1621 GENBANK NP_231138.1 ENTEKLKNSKEVIAYIAECFPNCFTLEGEAKPLKIGIFQDLADRLNDDPKVSKTQLRAALRQYTSSWRYLHGVKPG ATRVDLDGNPCGELEEQHVEHAQAALAESKARVEARRKEQVKKVREEAKANKPKAKKPQQARRPQNAPKVEKKPV ETRALAASELNVGNQVNVNMGKGNMAATIVEVNKEDVRVQLANGLQMVVKAEHLRA Vibrio cholerae NYSGXRC-2923d SGX Pharmaceuticals 2004-01-09 active Selected Cloned Expressed Soluble Purified sp|Q05014|LIPB_NEIMB ICEDB: T1783 GENBANK NP_389201.1 TTIKTSNLGFPRIDLNREWKKALEAYWKGSTDKDTFLKQIDELFLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVS FNWIPKRFRHLTDATDTYFAIARGIKDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVE TKPVIVGPYTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRGAKELFESIT SELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTHGFPTDKVLAAGVIDGRNIWKADLEES LDAVLDVLSIAKVDELWIQPSSSLLDVPVAKHPDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQ AKADIQALKQFATGANSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRRARQKWR KAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFTKYAWVQSYGSRCVRPPVIY GDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWSFPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQV DEPALREGLPLKTRDWDEYLTWAAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGF LDYLKNHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEETVAALKNMVEAAK QARAQQTQLV Bacillus subtilis NYSGXRC-2929g SGX Pharmaceuticals 2003-11-05 active Selected Cloned Expressed Soluble pir||S60783 GENBANK NP_462611.1 KILVIGPSWVGDMMMSQSLYRTLKARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEIGERRRLGHSLR EKRYDRAWVLPNSFKSALIPFFANIPHRTGWRGEMRYGLLNDARVLDKDAWPLMVERYVALAYDKGVMRAAKDLP QPLLWPQLQVSEGEKSLMCSDFSLSSERPLIGFCPGAEFGPAKRWPHYHYAELAKQLINEGYQVVLFGSAKDHEA GNEILAALNSEQQAWCRNLAGETQLEQAVILIAACKAIVTNDSGLMHVAAALDRPLVALYGPSSPDFTPPLSHKA RVIRLITGYHKVRKGDTAQGYHQSLIDITPQRVLEELHSLLSEEGV Salmonella typhimurium NYSGXRC-2929h SGX Pharmaceuticals 2004-01-09 active Selected Cloned Expressed Soluble Purified pir||S60783 ICEDB: T1784 GENBANK YP_001337616.1 KILVVGPSWVGDMMMSQSLYRTLRARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALAIGERRKLGHSVR ERRYDRAYVLPNSFKSALVPFFANIPLRTGWRGEMRYGLLNDARVLDKDAWPLMVERYVALAYDNGVMRCAKDLP QPLVWPQLQVNEGEKSQACSAFNLSNDRPIIGFCPGAEFGPAKRWPHYHYAALAKKLIDDGYQIALFGSAKDNEA GKEIIAAISSEQQAWCRNLAGETQLEQAVILIAACKAVVTNDSGLMHVAAALDRPLVALYGPSSPDFTPPLSHKA RVIRLITGYHKVRKGDAAEGYHQSLIDITPERVLQELNELLAEKTEHEEA Klebsiella pneumoniae NYSGXRC-2929i SGX Pharmaceuticals 2003-12-09 active Selected Cloned Expressed Soluble pir||S60783 GENBANK NP_439262.1 NILIIGPSWVGDMMMSHSLYQQLKIQYPNCNIDVMAPNWCKPLLARMPEVRKAIEMPLGHGAFELGTRYRLGKSLR EQYDMAIVLPNSLKSAFIPFFAKIVHRRGWKGESRYILLNDLRANKKDYPMMVQRYVALAFEKDVIPKADDIPVL KPYLTVEPAQQAETLKKFEKQTALLGERPIIGFCPGAEFGPAKRWPHYHYAKLAEMLITQGYAVALFGSAKDEPV GEEIRQALPEELREFCVNLAGKTNLNEAVDLIANCTAVVTNDSGLMHIAAAVNRPLIALYGPTSPQYTPPLSDKA TIIRLIEGELIKVRKGDKEGGYHQSLIDITPEMALEKLNELLAK Haemophilus influenzae NYSGXRC-2931l SGX Pharmaceuticals 2003-12-03 active Selected Cloned Expressed Soluble Purified sp|P44624|AMPD_HAEIN ICEDB: T1647 GENBANK NP_070933.1 FQSDLKLIVFQHGFFGERFVANLMNYPNSCPSYGACGIDGCTQCKEGLYNFSKNIIAVFSMPDPTTMPDFIENAED FLPKVIPEADIAVAINLHPDVLAVMPEKLKGKVKALIVPVEEPRWCSPGLAKQIREKCDELGLEFAAPKPFCNLR PSEEHPTINRMIEEMRIGYPEFEIELLEDGKAYVRISRSQPCGCAYYIGVKLRGFDFSEVKEGKMRELWNVVAEA HHSYPCTASMERDNEYNETLLHVGGYIARHAVNRALGYEGDEDIPEHIKHIVL Archaeoglobus fulgidus NYSGXRC-2940c SGX Pharmaceuticals 2003-11-13 active Selected Cloned Expressed Soluble gb|AAG04505.1|AE004542_1 GENBANK NP_388984.1 LTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTILLHNSEMTEDIEDRDEVEVFIYVDQQERLAATM KIPIISADEYGWVEVVDKVEDMGVFVDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPED IISELFTDASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKEDGSVNLSLL PRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKRALGHLMKNGKVYQENGWTYEKK Bacillus subtilis NYSGXRC-2949a SGX Pharmaceuticals 2004-12-14 active Selected Cloned Expressed Soluble Purified ref|NP_046593.1| ICEDB: T1453 GENBANK NP_815014.1 SVEHIEELDTLNQGRLKINAILDQSNASAEKVDAYQVQLTNGISEAKNIADEAGKEAVQIATDAGNQANETANQAM NNAKTAIMIAGNAVSTANNNKQEFDTLRNDFDQLVAEAGDSNPEIVQARTDTQGIKQATLANRLQIDLNDRMTKA DGISLLAKPTTVKMKLDFNGKTAGNTATNANSYSTDFTAKILKKPTEVWEEVSQADYNKMASRDDEGVKTGSTQS GVIPQQLAAFNLVEAAKKLIPQMFETVTTDEAVAFIRQNVQFFTINQRVKAAAPNNQTIKIATYLPTTDNWVTQI QESAKEFGDFSIQINDQNFITDEGFIYLMSYTDSSNGVTPASLEVDYVGLHIGLSVDAQAVLAKSGFVQAEQLNT HMENQDNPHQVTAEQVGLGNVENYGFASDSEAVAGTLTSKYMHPKNVAEAIKGQAVTQTGDQEIAGVKNFVTMPT VNGVPLESSRMAIYEASGVGEVEAKYQAAFNKDNMKFVLIRVGNRVDAFVRCNLSDPTKLNNNLVKVFTVPTGYT LSTKITKGIWNLALTAMQYTFPQPNCAGLYEMGNQGILFGANRAGNIYLQGSWYTDDPFPTK Enterococcus faecalis NYSGXRC-2959a SGX Pharmaceuticals 2003-05-15 active Selected Cloned Expressed Soluble Purified pir||F82284 ICEDB: T1452 GENBANK NP_814609.1 TEMLSTEDFDFDLPEELIAQTPLKDRASSRLLVVNKETGDMEDKHFHDILDELQPGDALVMNNTRVLPARLYGEKP ETGGHLEVLLLTNTEGDTWETLIKPAKRAKVGTEIQFGDGRLKAVVKEELEHGGRIIEFKYDGIFLEILESLGEM PLPPYIKERLDDPDRYQTVYAEENGSAAAPTAGLHFTKELLEEIKAKGVHLVYLTLHVGLGTFRPVSVDNIEEHH MHSEFYRLTEEAAKQLNEVRQAGGRIVAVGTTSIRTLETIGTKFNGEIQADSGWTDIFITPGYQFKVVEAFSTNF HLPKSTLVMLVSAFAGKDLTLAAYQHAIEEKYRFFSFGDAMFIK Enterococcus faecalis NYSGXRC-2959g SGX Pharmaceuticals 2003-05-15 active Selected Cloned Expressed Soluble Purified pir||F82284 ICEDB: T1466 GENBANK NP_286144.1 RVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGK IEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDERSVLDILNSIGHMPLPPY IDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHS EYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHL PESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE Escherichia coli NYSGXRC-2967a SGX Pharmaceuticals 2003-10-07 active Selected Cloned Expressed Soluble sp|P22262|PRFA_LISMO GENBANK NP_813880.1 RNVLQDYLDEHSFRVVVKKKKNYLTYEGLQDRYAYILKSGIIKTSVISKDGREFNLRYINNLEIVSLLRDEYSEFI DAPFNIRIESPQAELYQIDRVQFWRDINNSKDLQMYVKEYYRDRLMHSMKKMQQMLMNGKFGAVCTQIYEMYDSF GVETEEGILIDFVVTNEEIAHFCGITSASSVNRMMQQLKELGAIELRNRKILIKDLDMIRDN Enterococcus faecalis NYSGXRC-2970c SGX Pharmaceuticals 2003-11-13 active Selected Cloned Expressed Soluble Purified sp|P44013|Y552_HAEIN GENBANK NP_438710.1 LSLTAESCELFNIPFYQFAQMKKFCPEDIPAIKADYKLHWDNWKAIIQSVSAQLGTPFAKPHIESWTNGWQVRAHF FAYFKYEFNQNSAAIFSVLLNRRRLRVCLDWHCYRADRSQINVQQYNQWLDQFDFKQFADFEIWREDESEYDDFR QVKVISEKNLILRSDEDFWCIGKSIEKAELNQIDPVLFITHTIQQLQPLYDRCHQ Haemophilus influenzae NYSGXRC-2978c SGX Pharmaceuticals 2003-06-30 active Selected Cloned Expressed Soluble sp|P09163|YJAB_ECOLI GENBANK NP_418006.1 IREAQRSELPAILELWLESTTWGHPFIKANYWRDCIPLVRDAYLANAQNWVWEEDGKLLGFVSIMEGRFLAAMFVA PKAVRRGIGKALMQYVQQRHPHLMLEVYQKNQPAINFYQAQGFHIVDCAWQDETQLPTWIMSWPVVQTL Escherichia coli NYSGXRC-2978e SGX Pharmaceuticals 2003-06-30 active Selected Cloned Expressed Soluble sp|P09163|YJAB_ECOLI GENBANK NP_418436.1 VISIRRSRHEEGEELVAIWCRSVDATHDFLSAEYRTELEDLVRSFLPEAPLWVAVNERDQPVGFMLLSGQHMDALF IDPDVRGCGVGRVLVEHALSMAPELTTNVNEQNEQAVGFYKKVGFKVTGRSEVDDLGKPYPLLNLAYVGA Escherichia coli NYSGXRC-3008a SGX Pharmaceuticals 2003-05-16 active Selected Cloned Expressed Soluble Purified pir||H75351 ICEDB: T1460 GENBANK NP_815330.1 TELNREMIETLVRQIVTEKLMPTKQVDPSGIMSIKLPEIDVTEDDRLDTGNPADIVYTKDLFSLEESPRLGCGLMV MKDTTFDWTLEYDEIDYIISGQLDILIDGRKISATAGEIILIPKSSKIQFSVTGDARFVYVTYPADWQSQ Enterococcus faecalis NYSGXRC-3008c SGX Pharmaceuticals 2003-05-19 active Selected Cloned Expressed Soluble Purified pir||H75351 ICEDB: T1446 GENBANK NP_416955.1 KKLITANDIREAHARGEQAMSVVLRASIITPEAREVADLLGFTITECDESIPVTASVPASVPADKTESQRIRETII AQLPEGQFTESLVAQLMEKVMKEKQSLEQGAMQPSFKSVTGKGGIKVIDGSSVKFGRFDGAEPHCVGLTDLVTGD DGSSMAAGFMQWENAFFPWTLNYDEIDMVLEGELHVRHEGQTMIAKAGDVMFIPKGSSIEFGTTSSVKFLYVAWP ANWQSL Escherichia coli NYSGXRC-3008d SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble Purified pir||H75351 ICEDB: T1526 GENBANK NP_461403.1 KKLITANDIRAAHARGEQAMSVVLRASIITPEAREVAELLGFTITECDESVPASTSAQACKSESQRIREAIIAQLP EGQFTESLVAQLMEKVLKEKQSLELGTMQPSFTSVTGKGGVKVIDGSSVKFGRFDGAEPHCVGLTDLVTEQDGSS MAAGFMQWDNAFFPWTLNYDEIDMVLEGELHVRHEGETMIAKAGDVMFIPKGSSIEFGTPTSVRFLYVAWPANWQ SV Salmonella typhimurium NYSGXRC-3008e SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified pir||H75351 ICEDB: T1514 GENBANK NP_295527.1 NPAEVPPHPSPPAPCHARRMTQAKTYKVSRDETQHGKDSEHHLIAGYNSSMRLWHNEEPSDTADKTPRSHEYETLG YVISGQVELTVDGQTLTLSAGDSYRVPKGAEHVFRVTETLTAVEVTTPATNK Deinococcus radiodurans NYSGXRC-3026e SGX Pharmaceuticals 2003-05-21 active Selected Cloned Expressed Soluble Purified emb|CAC11811.1| ICEDB: T1454 GENBANK NP_290171.1 TTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRGSQTLPAWCENWAQEVDARLTKEAQ SALRPVINLTGTVLHTNLGRALQAEAAVEAVAQAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNN NAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHT SNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQA GIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAA HYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLE DEQRFLEMLLK Escherichia coli NYSGXRC-3028a SGX Pharmaceuticals 2001-05-10 active Selected Cloned Expressed Soluble sp|P17585|AADK_BACSU GENBANK NP_816483.1 RTEEEMFQLIMDVAKQEEHIRAVGMVGSRTNVKAPKDSFQDFDIVYIVEPCAEFFETATWIAKFGQPLIMQRPKEM TLFPTEPKTRETFLMLFEDGQRIDLTLCPLAEKDNWHEGDSLAIILLDKDENLPPLPVASDKNYTVTVPDQQQFN DCCNEFWWVSTYVVKGLCRNELFYAVTHLYEYCQQELLRLLSWQAAWQEPEPISVGKQFKYLKNYVTPDTMDQLA SLLDFSSKEACWNSLIKTQAFFDVVAQDFAKMAQFTYHLQEAKKVTEYTNSLRLKDLQGK Enterococcus faecalis NYSGXRC-3044a SGX Pharmaceuticals 2003-10-10 active Selected Cloned Expressed Soluble Purified gb|AAG08588.1|AE004933_4 ICEDB: T1622 GENBANK NP_816700.1 YRELMQKKNVRPYVLMARFGLEKENQRSTREGLLATTEHPTVFGNRSYHPYIQTDFSETQLELITPVANSGTEMLR FLDAIHDVARRSIPEDEMLWPLSMPPQLPTKDEEIKIAKLDQYDAVLYRRYLAKEYGKRKQMVSGIHFNFEYDQA LIQQLYDEQSEVTDCKQFKTKVYMKVARNFLRYRWLITYLFGASPVSEDRYFRVYDDQPQEPVRSIRNSTYGYRN HDNVKVSYASLERYLEDIHRMVENGLLSEEKEFYAPVRLRGGKQMSDLPKTGIRYIELRNLDLNPFSRLGIVEDT VDFLHYFMLYLLWTDEKEEADEWVKTGDIFNEQVALGHPHETIKLIAEGDRIFSEMIDMLDALGIRKGKEVVGKY YQQLRNPQDTVSGKMWTIIQENSNSELGNIFGNQYQSMAFERPYQLAGFREMELSTQIFLFDAIQKGLEIEILDE QEQFLKLQHGEHIEYVKNANMTSKDNYVVPLIMENKTVTKKILSAAGFHVPGGEEFSSFIEAQEAHLRYANKAFV VKPKSTNYGLGITIFKEGASLEDFTEALRIAFKEDTAVLIEEFLPGTEYRFFVLDNDVKAIMLRVPANVTGDGKH TVEELVAAKNSDPLRGTNHRAPLELIQLNDLEKLMLKEQGLTIYSVPEKEQIVYLRENSNVSTGGDSIDMTDVID DSYKQIAIEAVAALGAKICGIDLIIPDKDVKGTRDSLTYGIIEANFNPAMHMHVYPYAGQGRRLTMDVLKLLYPE VVQ Enterococcus faecalis NYSGXRC-3044c SGX Pharmaceuticals 2003-09-08 active Selected Cloned Expressed Soluble Purified gb|AAG08588.1|AE004933_4 ICEDB: T1623 GENBANK NP_230207.1 SKFAERLQTVANKPEVFQKFSRGLERESLRYTPEGALTQTPHPKALGAALTHRWITTDFAESLLEFITPVSHEVDT LLAQMSDIHHFAQTKLGDEKLWPLSMPCYVGSEEGIVLAQYGSSNTGKMKTLYREGLKRRYGSLMQIISGVHFNF SFPESFWDALFGEQEESARQASKSAAYFGVIRNYYRFGWLIPYLFGASPALCSSFLQGRKTDLPFESIGKTLYLP YATSLRLSDLGYTNSAQSVLQIGFNSIEQYLQGLNEAIRTPSAEFAKLGVKVEGEYRQLNSNVLQIENELYAPIR PKRVTQSGERPSQALARAGVEYIEVRSLDVNPFSPIGINEDQVRFLDLFLAWTALSDSDPMDGCELACWRDNWRK VVLEGRKPGLELQIGCHGEVLTLQAWAKRVFADLRVIAETMDAALGGDAYQAVCAKLETWIENPELTLSAQILAE IKQHGGLGKTGCALGNEYRAVNLQHQYQFYSQDEMEQEVRRSTQAQADIEAKETLNFDAYLTQYFAYLQAVS Vibrio cholerae NYSGXRC-3044d SGX Pharmaceuticals 2003-09-04 active Selected Cloned Expressed Soluble Purified gb|AAG08588.1|AE004933_4 ICEDB: T1785 GENBANK NP_461744.1 IPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIQ HMLTFMRDLHRYTARKLGDERMWPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYN FSLPMAFWQAKCGVTEGGSGKRKISAGYFRLIRNYYRFGWVIPYLFGASPAICSSFLQGKPTTLPFEKTDCGMYY LPYATSLRLSDLGYTNKSQSNLGITFNDLHEYVAGLKRAIKTPSEEYARIGVEKDGKRLQINSNVLQIENELYAP IRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCVLADAPEMSSDELLCTRTNW NRVILERRKPGLTLGIGCETAQFPLPKVGKDLFRDLKRVAQTLDSIHGGEEYQKVCDELVACFDNPELTFSARIL RSMIDEGIGGTGKAFGEAYRNLLREEPLEILQEEEFIAERDASVRRQQEIEAADTEPFAAWLAKHA Salmonella typhimurium NYSGXRC-3055c SGX Pharmaceuticals 2006-10-04 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB pir||F75429 ICEDB: T1507 PDB 1Z2L GENBANK NP_415049.1 PDB 2IMO PFAM PF01546 ITHFRQAIEETLPWLSSFGADPAGGMTRLLYSPEWLETQQQFKKRMAASGLETRFDEVGNLYGRLNGTEYPQEVVL SGSHIDTVVNGGNLDGQFGALAAWLAIDWLKTQYGAPLRTVEVVAMAEEEGSRFPYVFWGSKNIFGLANPDDVRN ICDAKGNSFVDAMKACGFTLPNAPLTPRQDIKAFVELHIEQGCVLESNGQSIGVVNAIVGQRRYTVTLNGESNHA GTTPMGYRRDTVYAFSRICHQSVEKAKRMGDPLVLTFGKVEPRPNTVNVVPGKTTFTIDCRHTDAAVLRDFTQQL ENDMRAICDEMDIGIDIDLWMDEEPVPMNKELVATLTELCEREKLNYRVMHSGAGHDAQIFAPRVPTCMIFIPSI NGISHNPAERTNITDLAEGVKTLALMLYQLAWQK Escherichia coli NYSGXRC-3055d SGX Pharmaceuticals 2005-11-04 active Selected Cloned Expressed Soluble Purified pir||F75429 ICEDB: T1490 GENBANK NP_391133.1 EKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQLAVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDE VIVTGSHIDTVINGGKYDGAYGVLAAMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQD AKEPRDESGVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRRYLVTLEGEC NHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNVANVIPGRVQFSIDIRHQHQHVLEQFH QDMVALINGICLQKGIRAVIDEYMRIEPVPMDERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFV PSRGGVSHSPKEYTSARQLEIGVRALTDLLYKLAY Bacillus subtilis NYSGXRC-3055e SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble Purified pir||F75429 ICEDB: T1649 GENBANK NP_438746.1 SINLNRVQNLIEKLAFISSVPNELTRLAFTEEDEKAHNMIIELCKEYDLSIRRDSIGNLFIRKAGKEDFLPAVAFG SHIDTVVNAGKFDGPLGSVAGLEILLQLCEQNIQTRYPLELIIFTCEESSRFNFATLGSKVMCGIVNQEKLSSLR DKQGKGLSEAMAEVGMNFNLVNQAKRDAKEFKCFFELHIEQGPRLENEGKTIGVVTGIAAPIRAIVKIKGQADHS GATAMHYRHDALLGGSELSLAIERAAIQAGHSTVATVGNITAKPGVMNVVPGYCELLVDIRGTHVQARDSVFELL QEEISKVSEKRGLLIELQLISKDNPIILPENMVNQIAETAHSLGYSYEIMPSGAGHDAMHMATLCPTGMIFIPSH LGISHNPLEFTDWKDIEAGIKVLQKVILEQAEVC Haemophilus influenzae NYSGXRC-3063d SGX Pharmaceuticals 2003-05-22 active Selected Cloned Expressed Soluble Purified sp|Q9ZFU9|EUTL_SALTY ICEDB: T1455 GENBANK NP_416934.1 PALDLIRPSVTAMRVIASVNADFARELKLPPHIRSLGLISADSDDVTYIAADEATKQAMVEVVYGRSLYAGAAHGP SPTAGEVLIMLGGPNPAEVRAGLDAMIAHIENGAAFQWANDAQDTAFLAHVVSRTGSYLSSTAGITLGDPMAYLV APPLEATYGIDAALKSADVQLATYVPPPSETNYSAAFLTGSQAACKAACNAFTDAVLEIARNPIQRA Escherichia coli NYSGXRC-3089c SGX Pharmaceuticals 2003-07-17 active Selected Cloned Expressed Soluble Purified emb|CAB73025.1| ICEDB: T1478 GENBANK NP_290822.1 AMSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPL MKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDL WIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSG DSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWE MKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL Escherichia coli NYSGXRC-3089g SGX Pharmaceuticals 2003-08-28 active Selected Cloned Expressed Soluble Purified emb|CAB73025.1| ICEDB: T1515 GENBANK NP_070093.1 KITWLGHAAFLLEGSMKVLIDPFLTGNPNAPVKPEEVKADYILVTHGHGDHLGDAVEIAKRNNAPIICIHELSRIL SRYDVETMGMNMGGTARTGSIAVTMVPAWHSADLEDEQGNIISAGLPAGFIVSMDGVRVYHTGDTDVFLDMQLIG ELHRPDVMLLPIGDYYTMGIAGAVKALELVKPKVAIPMHYNTFPLVEKDPEDFRKAVKAKGLDVEVVILKPGESY EFNK Archaeoglobus fulgidus NYSGXRC-3090d SGX Pharmaceuticals 2003-11-25 active Selected Cloned Expressed Soluble Purified gb|AAG07332.1|AE004812_7 ICEDB: T1651 GENBANK NP_252634.1 ADLTSLSIEHLRSPRLYTHRLILRPWLVQDRARFAELNADPLVMEFFPSCLDRAQSDALLRRIDAHFAEHGFGWWA LQVKGGDPFIGYVGLEVVDFDAPFVPAVAIGWRLAAEHWAEGFAHEAAEAALSYAFDTLGLDQVVAFTVPANENS LGLMERLGMHRDPTDDFEHPDLPPGHRLRHHVLYRLTREDWLRR Pseudomonas aeruginosa NYSGXRC-3114a SGX Pharmaceuticals 2003-10-09 active Selected Cloned Expressed Soluble Purified pir||C71837 ICEDB: T1556 GENBANK NP_816395.1 TFTEQAKDQAQASWQGSFQHPFITELHEGTLSPTIFRYYLIQDHYYLKHFSQLYRLIAAQTQQPRLKKLLLTNAEN LALGELAIRETFFEELAITEEEVAATPIAPTAYHYVSHMYRQLIEGTPKTAAASMLPCSWLYQEIGAQLVKQHSP EPLYQRWIETYAGEEAYQHVQEERQLLDQLYEESSPQEQAAMITAFVISSEMEYAFWEMAYTHETWIG Enterococcus faecalis NYSGXRC-3114e SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble Purified pir||C71837 ICEDB: T1652 GENBANK NP_223925.1 QVSQYLYQNAQSIWGDCISHPFVQGIGRGTLERDKFRFYIIQDYLFLLEYAKVFALGVVKACDEAVMREFSNAIQD ILNNEMSIHNHYIRELQITQKELQNACPTLANKSYTSYMLAEGFKGSIKEVAVAVLACGWSYLVIAQNLSQIPNA LEDAFYGHWIKGYSSKEFQACVTWNINLLDSLALASSKQEIEKLKEIFIATSEYEYQFWDMAYQS Helicobacter pylori NYSGXRC-3114f SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified pir||C71837 ICEDB: T1500 GENBANK NP_438520.1 IEQLIQQAQPYWQQYIEHEFVQQLAKGTLPKACFQHYLKQDYLYLFHYSRAFALGVFKAKNFAEMETPRKTLEILC QEIQLHLNYCREWGISEQEIFTTQESAACIAYTRYLLDCGMTGSLAELYAAVTPCALGYAQVARYITQHYPRLPN NPYQTWIDTYASEEFQQAAQETVDFLTALCKPLNPSQLAEIQQIFTTATRMEIAFWQMGLDLA Haemophilus influenzae NYSGXRC-3130a SGX Pharmaceuticals 2001-05-10 active Selected Cloned Expressed Soluble emb|CAB53840.1| GENBANK NP_815787.1 KILDACCGSRMFWFDKQNDQVLFMDNRKHYEKLESGHIVAVNPNIVADFRKMPFDDNSFYHVVFDPPHLLRAGSNS WLAKKYGKLNEQTWKEDIQKGFSECMRVLKPNGTLVFKWNEDQIKLSEILSIIDYEPLYGNKRAKTHWLVFMKES EENESNG Enterococcus faecalis NYSGXRC-3135c SGX Pharmaceuticals 2003-11-18 active Selected Cloned Expressed Soluble emb|CAB65148.1| GENBANK NP_391392.1 KQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALSVHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSA VKKVKEVDLDLNFGHAYDVQHIFQFKDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQ HIECEIKGNKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSFSYLTAEKAI AETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINVTESDCRSIYAKTTTGNVELAIPDDLA VKAELKSNLGTLSHELMDVEMLKEKNDTIQKEMMFTSNQAHDQNITVFSESLTGAIKLKYSQR Bacillus subtilis NYSGXRC-3162a SGX Pharmaceuticals 2003-10-22 active Selected Cloned Expressed Soluble gb|AAF42161.1| GENBANK NP_232972.1 TDEQFNPQDEEIEIEAIGVEVSCQPIELYKVLKIANAVSGGGEAKHVISEGYVFVNGDVETRKRCKVFDGDLIEFN QEFYLVICDAPVTEPESFDTQPELASSHKPTKTQKKSSANTSAKSKPSKNNKTVSGQKKAKNDKKSPQSDSKSPS GRSAIRFF Vibrio cholerae NYSGXRC-3181f SGX Pharmaceuticals 2001-04-11 active Selected Cloned Expressed Soluble gb|AAF41140.1| GENBANK NP_273769.1 TISNEDNMILMSRYPDKYFDLAIVDPPYGILNKTKRGGDYKFNMNEYSQWDIKPDQTYFNELFRVSKNQIIWGGNY FGELWLRSEYNKGFIIWDKNQPETLNNFSMAEMAWSSFDRPSKIFRFSVRKNRNKTHPTQKPVELYQWLLKMYAK QGDKILDTHLGSGTLAIACCIAQFDLTACEINSDYYQQSIEKIKNNLPEARISFGHPGYCIIE Neisseria meningitidis NYSGXRC-3184d SGX Pharmaceuticals 2003-09-25 active Selected Cloned Expressed Soluble Purified pir||E70080 ICEDB: T1624 GENBANK NP_645679.1 IKTEFKGNNIPYEYAAGADVSDSINGNPIKSFPFEVIELPEGTKYLAWSLIDYDAIPVCGFAWIHWSVANVSVSGN SISIKADLSRTKGDYVQGKNSFTSGLLAEDFSEIENHYVGPTPPDQDHQYELTVYALDHSLNLKNGFYLNEFLKE VNQHKIDQTSINLIGRK Staphylococcus aureus NYSGXRC-3190c SGX Pharmaceuticals 2003-09-08 active Selected Cloned Expressed Soluble Purified pir||C81250 ICEDB: T1492 GENBANK NP_391543.1 KIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAILEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLH VEAGRALISILKDAKHTRLLVVGGAGSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSP AAFFDPAGKRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE Bacillus subtilis NYSGXRC-3200c SGX Pharmaceuticals 2003-07-08 active Selected Cloned Expressed Soluble pir||C69800 GENBANK NP_415981.1 KPQVYHVDAFTSQPFRGNSAGVVFPADNLSEAQMQLIARELGHSETAFLLHSDDSDVRIRYFTPTVEVPICGHATV AAHYVRAKVLGLGNCTIWQTSLAGKHRVTIEKHNDDYRISLEQGTPGFEPPLEGETRAAIINALHLTEDDILPGL PIQVATTGHSKVMIPLKPEVDIDALSPDLNALTAISKKIGCNGFFPFQIRPGKNETDGRMFSPAIGIVEDPVTGN ANGPMGAWLVHHNVLPHDGNVLRVKGHQGRALGRDGMIEVTVTIRDNQPEKVTISGTAVILFHAEWAIEL Escherichia coli NYSGXRC-3200e SGX Pharmaceuticals 2003-11-20 active Selected Cloned Expressed Soluble Purified pir||C69800 ICEDB: T1654 GENBANK NP_388728.1 KEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAGYSETSFIRKSESADLELRYFTPGHEMNLCGHAT VASLYALCEKGMLESGKTYSIQTKAGILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDL PIVFGSTGIWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSPYSGTIEDPV TGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVKVNMTGTAVYSETRILKI Bacillus subtilis NYSGXRC-3209a SGX Pharmaceuticals 2004-01-07 active Selected Cloned Expressed Soluble Purified gb|AAG06109.1|AE004700_5 ICEDB: T1625, T1786 GENBANK NP_814662.1 PKFSPCLWFNTQAEEAANFYTTIFEKGAILSKTNYVNEEHQPQGTSLMTIEFTLANQTIIGLNGGPEFSFTPASSF FVECTTLPQTETLWKNLTADGQILMPFGEYPFSPLYGWVVDKFGVSWQVSFSGKEQTIVPTFMFANEKYGEAAKA LSEWLAIFGPGEIIEKVEYEDGNIAQALFTLQEQPFRVMDARDKHDFDFTMAFSIYIDCENQEEIDRLWQQVTAK GKEWPCGWMEDQFGVSWQTGNPELKRYLSDSNPARANEVTKKLYQMKKIDLNQLKEVYDKYNH Enterococcus faecalis NYSGXRC-3209e SGX Pharmaceuticals 2003-11-20 active Selected Cloned Expressed Soluble Purified gb|AAG06109.1|AE004700_5 ICEDB: T1787 GENBANK NP_251411.1 NSKNTICLWYDSAALEAATFYAETFPDSAVLAVHRAPGDYPSGKEGDVLTVEFRVMGIPCLGLNGGPAFRHSEAFS FQVATDDQAETDRLWNAIVDNGGEESACGWCRDKWGISWQITPRVLSEAIASPDRAAARRAFEAMMTMGRIDIAT IEKAFKG Pseudomonas aeruginosa NYSGXRC-3219d SGX Pharmaceuticals 2003-10-14 active Selected Cloned Expressed Soluble sp|P77402|YDIP_ECOLI GENBANK NP_416211.1 YQRCFDNASETLFVAGKTPRLSRFAFSDDPKWESGHHVHDNETELIYVKKGVARFTIDSSLYVAHADDIVVIERGR LHAVASDVNDPATTCTCALYGFQFQGAEENQLLQPHSCPVIAAGQGKEVIKTLFNELSVILPQSKNSQTSSLWDA FAYTLAILYYENFKNAYRSEQGYIKKDVLIKDILFYLNNNYREKITLEQLSKKFRASVSYICHEFTKEYRISPIN YVIQRRMTEAKWSLTNTELSQAEISWRVGYENVDHFAKLFLRHVGCSPSDYRRQFKNCFAEQEILSEFPQPVSLV G Escherichia coli NYSGXRC-3231e SGX Pharmaceuticals 2003-11-19 active Selected Cloned Expressed Soluble gb|AAF95969.1| GENBANK NP_228220.1 KILVSACLLGLPTRYDGRSVADERVLSLLKRHDLIPVCPEQLGGLPTPRPRCEIYGGCGWTGKERVLDEFGSDRTE NFLRGAETTLKVARLLKVDLAILKSKSPSCGKRFVYDGSFSGRLVPGKGVTAFVLERNGVEVLDETEIPGDL Thermotoga maritima NYSGXRC-3236h SGX Pharmaceuticals 2003-10-08 active Selected Cloned Expressed Soluble Purified gb|AAF81086.1|AF228498_6 ICEDB: T1627 GENBANK NP_816597.1 ENEPILLLTHNGWGLELVKSVQMIVGEVTNVHEVALQAEDSLGDYLERVTEKIDQLTWHNQLLILTDVKGGTPSNV ALRLSKDYDLLIVSGLCTSLLLESVMKQSGPGFRLEDAEMIQQAAVDSCQILEIPK Enterococcus faecalis NYSGXRC-3269a SGX Pharmaceuticals 2003-10-08 active Selected Cloned Expressed Soluble Purified pir||C71885 GENBANK NP_815095.1 KNYFLQRRTLMTEQLPNCPECGSAYAYEDRGLFICPECGHEWSPTEEVAEEGLVVKDSNGNLLADGDSVTVIKDLK VKGASGAIKQGTKVKNIRLVEGDHNIDCKVDGFGPMKLKSEFVKKN Enterococcus faecalis NYSGXRC-3269e SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified pir||C71885 ICEDB: T1516, T1661 GENBANK NP_273103.1 SLPPCPQCASEYTYEDGGQYICPECAHEWNETESAADLAAQVRDANGAVLQNGDTVILIKDLKVKGSSMVIKQGTK VKGIRLQEGDHNIGCKIDGSAMNLKSEFVKKA Neisseria meningitidis NYSGXRC-3269h SGX Pharmaceuticals 2003-09-08 active Selected Cloned Expressed Soluble Purified pir||C71885 ICEDB: T1517 GENBANK NP_232939.1 GTMSTEATLLERCQSQCELCAASTPLSPFVVAPHALVTVDHAVMLCDTCKGQIENPETVDMNHWRCLNDSMWSQVQ PVQVLAWRQLKRISETEGWARDLLDMMYLDEETAKWAEIGMDDDAEKPRDVNGVELKKGDDVTVIKDLPVKGSSM VIKQGTAVRGIALTEDPKHIQGKVNGQTMYIIAEYCRKK Vibrio cholerae NYSGXRC-3282g SGX Pharmaceuticals 2003-06-26 active Selected Cloned Expressed Soluble Purified pir||F75418 ICEDB: T1505 GENBANK NP_295928.1 SAKPLRSLLYVPGDKPRAIEKARTLGADAVILDLEDAVAPEHKGAARANVQAALAESWPCPVLVRVNGLGTEWEHA DREMALLAGVDGLVLPKVEEGRSVTELHLRVPLWAMIETPRGVLNAPAIAAAPGVAGLLVGANDLARALRTQPQP ERLPLLHALSAVVLAARAAGKLPIDAVYNDVRDPAGFVRECEQGRTLGFAGKTVIHPDQVAAANSAFGVSDEQAQ AARDLLAAWDAARQEGKSVATWRGALVEQMHVDEAHEQLALWE Deinococcus radiodurans NYSGXRC-3284c SGX Pharmaceuticals 2003-09-09 active Selected Cloned Expressed Soluble Purified pir||D70830 ICEDB: T1494, T1599 GENBANK NP_214957.1 AAQELLRDAFTRLIEHVDELTDGLTDQLACYRPTPSANSIAWLLWHSARVQDIQVAHVAGVEEVWTRDGWVDRFGL DLPRHDTGYGHRPEDVAKVRAPADLLSGYYHAVHKLTLEYIAGMTADELSRVVDTSWNPPVTVSARLVSIVDDCA QHLGQAAYLRGIA Mycobacterium tuberculosis NYSGXRC-3286g SGX Pharmaceuticals 2003-09-18 active Selected Cloned Expressed Soluble gb|AAG05726.1|AE004660_2 GENBANK NP_390905.1 KHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSERDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMM RVRMAANDLPDLFDTHGWGKIRYGEYTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDR YGIAPPETMDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLINGTFQWSKFT YLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDVAQINPNVKVGIIPTPAIHPGDDPIWI GGERYTLAAWKDSPQLKEAKDFIAFMARPANAKQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYL PNGMWDVLGTVGQELAADILAPQDISQKLGREYKRLREQSETQGAENNE Bacillus subtilis NYSGXRC-3302d SGX Pharmaceuticals 2003-11-25 active Selected Cloned Expressed Soluble Purified pir||C81348 GENBANK ZP_01677888.1 NKEFIMKFSLKSLLTIAAAASTLILAGCGEKAVDNNKVKIGVMAGAEAQVAEVAAKVAKEKYNLDVELVTFTDYVT PNAALDDGSIDANAFQHKPYLDKQIADRGYKLAIVGNTFVYPIAGYSKQIKSVDELQDGARIAVPNDPTNLGRSL LLLQQQGLLKLREDVGLLATVRDIVENPKKLEILELDAAQLPRSLDDVALSIINTTYASSINLTPEKDGIFVENK ESPYVNILVAREANVNAENVQNFKKAYQTDEVAKAASEIFQGGAVKGW Vibrio cholerae NYSGXRC-3316c SGX Pharmaceuticals 2003-09-23 active Selected Cloned Expressed Soluble gb|AAG05700.1|AE004657_7 GENBANK NP_415951.1 ENLARFLSTTLKQLRQQRGWSLSRLAEATGVSKAMLGQIERNESSPTVATLWKIATGLNVPFSTFISPPQSATPSV YDPQQQAMVITSLFPYDPQLCFEHFSIQMASGAISESTPHEKGVIEHVVVIDGQLDLCVDGEWQTLNCGEGVRFA ADVTHIYRNGGEQTVHFHSLIHYPRS Escherichia coli NYSGXRC-3332d SGX Pharmaceuticals 2003-12-10 active Selected Cloned Expressed Soluble Purified sp|P43013|ACPD_HAEIN ICEDB: T1662 GENBANK NP_373448.1 AKVLYITAHPFNELVSNSMAAGKAFIETYQQQHPDDEVKHIDLFETYIPVIDKDVLTGWGKMSNGETLTDDEQMKV SRLSDILEEFLSADKYVFVTPMWNLSFPPVVKAYIDAISIAGKTFKYSAEGPQGLLTDKKVLHIQSRGGYYTEGP AADFEMGDRYLRTIMTFLGVPSYETIIIEGHNAEPHKTEEIKATSINNAEKLATTF Staphylococcus aureus NYSGXRC-3339a SGX Pharmaceuticals 2003-11-04 active Selected Cloned Expressed Soluble Purified EF1708 ICEDB: T1629 GENBANK NP_815414.1 PFAM PF06824 VYTEVPKSVATFMETITEKCGEAHQDWAKNFQAAFANTLLTTVKRQEDGTTFLLTGDIPAMWLRDSTAQVRPYLVI AKEDEDLAQMIAGLVKRQFRYICIDPYANAFNETDNHAGHQTDKTEMNGWIWERKYEIDSLCYPVQLAYLLYKNT GMTEQFNSDFVEGVKKILNVFTTEQDHAQSPYLFERDTWRQEDTLVEAGKGTPVGKTGMTWSGFRPSDDACQYGY LVPSNMFAVVILGYIQEIFSDVLEDATIGAIAKKLQEEIEEGIQTFGRTKNQNNETIYAYEVDGLGNASVMDDSN VPNLVAAPYLGYCSTEDEQYLTTRQTLLSKENPYFYEGKYAKGIGSSHTPENYVWPIALAMEGMTTKDKAEKERI LDLLVATDAGTHLMHEGFDVDNPENYTREWFSWANMMFCELVMDYFDIRVEK Enterococcus faecalis NYSGXRC-3342d SGX Pharmaceuticals 2003-11-19 active Selected Cloned Expressed Soluble gb|AAB51061.1| GENBANK YP_185578.1 KKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTPKQAPYLSELSDDVDVIEMTNR TLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTWHASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDF YLVGCEQMSQCFKQSLGATEEQMLYFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDK AYFEKCLPGYTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEGTYDQVR GLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEYIDKMVTK Staphylococcus aureus NYSGXRC-3351a SGX Pharmaceuticals 2003-11-04 active Selected Cloned Expressed Soluble Purified EF1469 ICEDB: T1630 GENBANK NP_815190.1 TDVNVKIDIMHPQPIVGLGNPAIFVQGSTQNYKEYTSLETLAKDFATTTTVYKKAEIIWKQENKPQTIAVVTFVAD TPTSPEQPDSLIAGSGIIAAATSYFYNDWHFALLANFVEADALALSNLIEENEFKFLVIQTATVDELTVFTGNNL TIGLVHPLEEFLDAALIGNTASLTVGSVTWKFRHNLVGITPNTLTTSQLQAIEKANAIAYVSKAGIPQTSEGKTM SGEFIDALHGDHWVKSNIETNVQRLLSTTDKLTFDSNGIALLDTTVANVLETAFNNGIVDIVDETGVGNYSVTAL GRQDLNPDDIAARNYKGLSFKYKRSGAIHTVDVTGTIEV Enterococcus faecalis NYSGXRC-3367a SGX Pharmaceuticals 2003-11-03 active Selected Cloned Expressed Soluble EF0685 GENBANK NP_814435.1 HKRMKKKLILAAAGAMAVFSLAACSSGSKDIATMKGSTITVDDFYNQIKEQSTSQQAFSQMVIYKVFEEKYGDKVT DKDIQKNFDEAKEQVEAQGGKFSDALKQAGLTEKTFKKQLKQRAAYDAGLKAHLKITDEDLKTAWASFHPEVEAQ IIQVASEDDAKAVKKEITDGGDFTKIAKEKSTDTATKKDGGKIKFDSQATTVPAEVKEAAFKLKDGEVSEPIAAT NMQTYQTTYYVVKMTKNKAKGNDMKPYEKEIKKIAEETKLADQTFVSKVISDELKAANVKIKDDAFKNALAGYMQ TESSSASSEKKESKSSDSKTSDTKTSDSEKATDSSSKTTESSSK Enterococcus faecalis NYSGXRC-3371a SGX Pharmaceuticals 2004-11-01 active Selected Cloned Expressed Soluble Purified EF1086 ICEDB: T1631, T608 GENBANK NP_814817.1 EIHFEKVTSDNRKAVENLQVFAEQQAFIESMAENLKESDQFPEWESAGIYDGNQLIGYAMYGRWQDGRVWLDRFLI DQRFQGQGYGKAACRLLMLKLIEKYQTNKLYLSVYDTNSSAIRLYQQLGFVFNGELDTNGERVMEWTHQNK Enterococcus faecalis NYSGXRC-3371c SGX Pharmaceuticals 2003-11-18 active Selected Cloned Expressed Soluble Purified pir||B69595 ICEDB: T1788, T609 GENBANK NP_390537.1 SINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHYYKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRV WLDRFFIDERYQGKGLGKKMLKALIQHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL Bacillus subtilis NYSGXRC-3379a SGX Pharmaceuticals 2001-06-04 active Selected Cloned Expressed Soluble emb|CAB73461.1| LSEKTDLENTEAFNKESVKDLRKLSTKDINGKDFTSKDFEKYDLTMVNVFATWCTACVKEIPDLVEVQNEMKSKGV NIVGVVTDPVDDNGENKEAIEKSKLIHEKTKASYPFLMPDKTNFNGRLNGIQAMPETFFVDSNGETKVVLDKAIR ICMECIGIG Enterococcus faecalis NYSGXRC-3379d SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble emb|CAB73461.1| GENBANK NP_282354.1 KILLLVAISCLFVACSNDKEKQQNDVNLSTEASINQSDDMNFKLNLIDGGSISVKKENAVLNFNDEDKVTLFVFFT TWCTPCIAEIPHLNKLQEKYNNDFNIVGVLLEDKSNDEIQKFIEQHKISYKVANGENNYLLAKALGGVNGIPTMF LYNKHSKLINQYLGLIPEEMLEIDIQKAIL Campylobacter jejuni NYSGXRC-3383a SGX Pharmaceuticals 2006-10-22 active Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data EF1512 ICEDB: T1527 GENBANK NP_815233.1 KYDLKYLSVPLPEEIQRVKEFGDFASADIAIDFWLTKELPQALKERLIIEKDVIKMMRMNEYPHSFAKADQMMRDT FQDYQTEELIRLKETGLVDWVYIDGEPYFQLRFLANLIKTNAAYVARLREAESNQLEILRKKELKENIEQMQKNG GRKVRTTIKATIQVKKEFERPGERVRVHLPLPKACQQQSEIEILATSPEATYIAAEDAPQRTLCFETILKENQTF TVEYCYVNRMVYQQLEENNVDKMQPSFDLEEQLPHIRFTPYLRNLADEIVGDESNPLKKARLIYDFVTTKIHYSF MREYFTISNISEYAATNLKGDCGVQAILFITLCRIAGIPAKWQSGLYVSTHYTGCHDWAQFYIKPYGWLFADLSF GGGAYRDGDRQRWNHYFGNLDVFRMVANSEIQADFQPAKMQLRADPIDNQRGEFEYENEGLPYACLIVSQERLSM EELPFD Enterococcus faecalis NYSGXRC-3383c SGX Pharmaceuticals 2003-12-02 active Selected Cloned Expressed Soluble Purified sp|P44103|YA48_HAEIN ICEDB: T1663 GENBANK NP_227823.1 EFLIYSLPEEVLREEMLGNFSVALKLIDDFLKKDLPLLQRERLIYEKERIERLLEDYPFTEKEAMEKMREMFEGFS EGEFQYLMNEGVLDYIVVEGEKRFERRFFHNLAFVRSEYRERLRKDERSEKARRILHERLERLIKGEDPKRYRIR ARITLKLKETSSKHRVWLPFPKESLQIESVKLLRTSHKSYYISPNDVPQRTIYFEGEDSTFFVEFEYIVREWVNH VDPERVSEKVAGFEEFLKEEPPHIVFTPKLRWLTQTVVGSEVNPYLKAKRIYDWITLNVRYSYVKPYALYENITD FVVNNLKGDCGFQALLFITMCRIAGVPARWQSGWYINPIFGSPHDWALFYVEPYGWLPADLSFGGARRDNESFRS FYFGNLDGFRMVANDGFMKDFDPKTRFVRSDPTDNQVGEAESEEKRLPFESTIEVISFEEV Thermotoga maritima NYSGXRC-3383e SGX Pharmaceuticals 2003-08-28 active Selected Cloned Expressed Soluble Purified sp|P44103|YA48_HAEIN ICEDB: T1518 GENBANK NP_439207.1 KKLIAVAVLSACGSLAHANTNIPNYNTDAHLYEFTQTYDLVVPKGSQGQTNLWVPLPFNGEYQQVKSIHFEGNYMN AYVTENNKYGAKTLFATWNKDAQKRDLKVMMVIETKDREPMVKGALENYTPPKDIQYSVDVQEYLKATPHIKTDG IVKEFPDKILGKETNPLKKAELIHHWFVKNMERDNSVLGCGDGDVEKILTTGVLKGKCTDINSVFVALARAAGIP AREIFGIRLGAAEKMGKYSKGAFGSANEQGIANVSGGQHCRAEFYLAGFGWVPVDSADVAKMRLAEKKSVEDKDT QAVAKYLFGNWEANWVGFNHARDFDLYPQPELAPINNFGYPYAEVGGDPLNSFDPKEFKYDYVSKKL Haemophilus influenzae NYSGXRC-3388c SGX Pharmaceuticals 2003-11-25 active Selected Cloned Expressed Soluble Purified pir||E72385 ICEDB: T1789 GENBANK NP_228186.1 ITDGIMHKVREVYQLLRKEPGIIVGVSNRHVHLSREDLETLFGEGYELTPVKELRQPGQYAAKETVTIVGPKGAIE NVRVLGPVRKETQVEISRTDAFRLGVRPPVRDSGDLEGTPGIVIIGPNGILVKEKGVIIAKRHIHMHPKDAEYYG VKDKDIVKVIVESGDRRLIFDDVLIRVREDFALEFHVDTDEANAAMLNTGDLVYIVEF Thermotoga maritima NYSGXRC-3394f SGX Pharmaceuticals 2003-07-07 active Selected Cloned Expressed Soluble Purified pir||C69897 ICEDB: T1632 GENBANK NP_293735.1 TKFVSAPLICGLALLGALSAAHAQTGIPALPPIAQPLPVPAPAPVTPPAPTVPVPQEPAPVPQPPMPQPSVPQTPA PQKPVTPRPAPAPSRAPLLIQARANVPALVAGKKTTVPVLKTLTIPAERAAQLRQRGEVSASLQADLDTFLKSLA APRDARFEQQDDGQWAVVQPNGLKVDAQATRAAVAKVLRDPRGVSANVVVTGQVAPQRTLDFFASRGITTFLATG FTSYYGSSPERVKNIHVGAQNFKDRLFEGDVFSFNKFIGPVSERNGYVPGLVIAGDQTASGVGGGICQVSTTVFR TLYGAGLGIVQRQNHSYQVFYYDPQGLDATIYQPQLDLKFANTTGGPIWFQTEWDDQEATLTITAFGQARDYQVQ VDAPKTLKTVAPPKDRLIPDASLPAGQRKQVDWAAPGATIEVTRRFTRGGKTFKQDTLRSVYRPWPNIFRVGTKK Deinococcus radiodurans NYSGXRC-3412a SGX Pharmaceuticals 2003-11-06 active Selected Cloned Expressed Soluble Purified EF_0734 ICEDB: T1528 GENBANK NP_814483.1 AKRIVGSTPKQDGFRMPGEFEPQEKVWMIWPERPDNWRDGGKPVQEAFTNVAKAISQFTPMNVVVSQQQFQNCRRQ LPPEITVYEMSNNDAWVRDCGPSFVINDHGEIRGVDWTFNAWGGLVDGLYFPWDQDDLVAQKICEIEHVDSYRTD DFVLEGGSFHVDGQGTVLTTEMCLLSEGRNPQLSKEAIEQKLCDYLNVEKVLWLGDGIDPEETNGHVDDVACFIA PGEVACIYTEDQNSPFYEAAQDAYQRLLKMTDAKGRQLKVHKLCCPVKNVTIKGSFKIDFVEGTMPREDGDICIA SYMNFLITNDGVIVPQYGDENDHLALEQVQTMFPDKKIVGVNTVEVVYGGGNIHCITQQEPKR Enterococcus faecalis NYSGXRC-3432a SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified EF0338 ICEDB: T1584 GENBANK NP_814130.1 EWIKQILAKHMKEDGTLDMEAANKEIDKEFPVNAVPKDQYNNLSSQLAEANKTLKSLEAKTKDNPDVQKELADLKE KADALEKENKDLKINSQVSAALQSAGAKDIDYALFKLGELELDKDGNVKDLESKVKDLKASIPDYFEKKDTLDDK SKKKTENKAGYQPIDNKLPKGKEPNEKDPFEAILSKYE Enterococcus faecalis NYSGXRC-3437a SGX Pharmaceuticals 2003-11-06 active Selected Cloned Expressed Soluble Purified EF0639 GENBANK NP_814393.1 KEELQLKQKLGGQKMVIQGDTLENSARRLLQERGVTMNDLAELVLFLQKDYIDNLTLDTCLESVDAVLTKREVHNA IITGVQLDILAEENKLLSPLQEILTEDEGLYGIDEIMALSIVNVYGSIGFTNYGYIDKVKPGILKELNAHDGEHV HTFLDDIVGAIAAAAASRLAHSQPDLSDITK Enterococcus faecalis NYSGXRC-3437d SGX Pharmaceuticals 2003-11-18 active Selected Cloned Expressed Soluble Purified gb|AAC98898.1| ICEDB: T1790 GENBANK NP_391108.1 SENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLTIDECTLNVNRVLAKREVQNAILTGIELDVLAEQ KKLSEPLQTMLEIDESLYGVDEVLAFSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISA AASSRLAHRARHTE Bacillus subtilis NYSGXRC-3465d SGX Pharmaceuticals 2003-09-04 active Selected Cloned Expressed Soluble Purified sp|O05252|YUFN_BACSU ICEDB: T1529 GENBANK NP_391032.1 AGTILGACGNSEKSSGSGEGKNKFSVAMVTDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYT TNLNKLARENFDLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAALSSKSGK IGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAESMYKSGVDVIYHSAGATGTGVFTE AKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNVTLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGV GISPSKQNLSDDVIKAVDKWKKKIIDGLEIPATEKELKTFKAE Bacillus subtilis NYSGXRC-3465g SGX Pharmaceuticals 2003-11-18 active Selected Cloned Expressed Soluble sp|O05252|YUFN_BACSU GENBANK NP_212517.1 NKILLLILLESIVFLSCSGKGSLGSEIPKVSLIIDGTFDDKSFNESALNGVKKVKEEFKIELVLKESSSNSYLSDL EGLKDAGSDLIWLIGYRFSDVAKVAALQNPDMKYAIIDPIYSNDPIPANLVGMTFRAQEGAFLTGYIAAKLSKTG KIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISTQYIGSFADLEAGRSVATRMYSDEIDIIHHAAGLGGIGAIE VAKELGSGHYIIGVDEDQAYLAPDNVITSTTKDVGRALNIFTSNHLKTNTFEGGKLINYGLKEGVVGFVRNPKMI SFELEKEIDNLSSKIINKEIIVPSNKESYEKFLKE Borrelia burgdorferi NYSGXRC-3465h SGX Pharmaceuticals 2001-03-08 active Selected Cloned Expressed Soluble sp|O05252|YUFN_BACSU GENBANK NP_295793.1 TRFSVSPGDPMKKFVTLALTLSTLGASVASAQAVRVGMAYDAGGKADKSFNQSAYEGSQLAAKKLGIQVKDFEPSD PSQIIQGVRSFAKEGFDLTIGVGFSNNASITQVAKENPDLYFGLVDDVSTAKNVASLVFNEEQGSYLVGYLAAMN SSTGVVGFIGGMNIPLIHKFEAGYRAGVKAANPKATIISQYVGNTPEAWNNPGKAKEIAANMRGRGADIIFAAAG GSGNGLIDYIKQTPCLNASQLPKGVTFKSDNFKNVKKSAAYAKACTGNTRPMFFIGVDSNQNYLGDFDKNPATLN HGLTSMVKRVDNAVYALINEVKNDKFKAGERRFGLKDGGVAYAVDQYNKALLPAAQIAKVEAVKQQIIKGQIKVP TK Deinococcus radiodurans NYSGXRC-3475a SGX Pharmaceuticals 2007-06-11 active Selected Cloned Expressed Soluble Purified Crystallized gb|AAG04641.1|AE004555_1 ICEDB: T1481 GENBANK NP_814178.1 MEEMVVVTPEKLEKLMKQKLEAAGLHSEHAEEVARHLTFADASGIHSHGAVRMDYYAERIAKGGITIDPELSFEKT GPSTAIFHGDNGVGQFVCNEALAAAVDLAKESGVAYVGVSQTSHSGTLSYYVKKAAEQGMVALSMCQSDPMVVPF GGTSNYFGTNPIAFAAPRAGHEPVVFDMATTVQAWGKILDARSRDVEIPDTWAVDEKGQPTTDPYEVRGLLPISG PKGYGLMMMVDVLAGSLLGLPFGKHVSSMYADLTEKRNLGQMFLVIDPSRFTDSERFKENINQMVEELHCVPTAE GFQQVYYPGEIGQLNYQKAMSEGIEIPQSIYDYLVSEIVHYDKYGGQGAF Enterococcus faecalis NYSGXRC-3475g SGX Pharmaceuticals 2003-07-01 active Selected Cloned Expressed Soluble Purified gb|AAG04641.1|AE004555_1 ICEDB: T1482 GENBANK NP_415322.1 ESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKTVKEA GAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAP FHGRDSRFGTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGS LLTFAEHKGYALAAMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKASP HDDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS Escherichia coli NYSGXRC-3491a SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified gb|AAB50407.1| ICEDB: T1633 GENBANK NP_816852.1 KKKLLLMVSVLAVLFVAAACSSKPEAKINTEPYSDRQTMLGTYVQIRIYDDGKEDVLPKAFARVKELGDKITVNQP GSEIDEINQEAGVKPVKVSDDLYPLLKKAYEYSKDSRGGFDMAIGPITSMWHIGFDDARKPSQAEIDQALKLVDY TKVKFNDKEQTVYLEEKGMQLDLGAIAKGFITDEVVKVLKDNGVTTAIVDLGGNVYVLGHSPRGKDMDWTVGIQD PNKARNTVLGQVKESNKTLVTSGIYERYLKVDGKTYHHLFDRETGYPFDNDIAGVTIITDKSIDGDGLSTAVFSM GVKKGLEYVESLKGTDAIFVTKDDKVYISKDIEGNFEIGKDSGYTMGNRADLK Enterococcus faecalis NYSGXRC-3491e SGX Pharmaceuticals 2003-09-25 active Selected Cloned Expressed Soluble Purified gb|AAB50407.1| GENBANK NP_438340.1 KKLISGIIAVAMALSLAACQKETKVISLSGKTMGTTYHVKYLDDGSITATSEKTHEEIEAILKDVNAKMSTYKKDS ELSRFNQNTQVNTPIEISADFAKVLAEAIRLNKVTEGALDVTVGPVVNLWGFGPEKRPEKQPTPEQLAERQAWVG IDKITLDTNKEKATLSKALPQVYVDLSSIAKGFGVDQVAEKLEQLNAQNYMVEIGGEIRAKGKNIEGKPWQIAIE KPTTTGERAVEAVIGLNNMGMASSGDYRIYFEENGKRFAHEIDPKTGYPIQHHLASITVLAPTSMTADGLSTGLF VLGEDKALEVAEKNNLAVYLIIRTDNGFVTKSSSAFKKLTETKE Haemophilus influenzae NYSGXRC-3498d SGX Pharmaceuticals 2003-10-02 active Selected Cloned Expressed Soluble Purified sp|P46536|PYRK_BACCL GENBANK NP_816202.1 KVGISMFNILQSTQLSSNTFDFWLEAPRIATHAQAGQFVILRIDEKGERIPLTIAETNPQAGSIRIIFQVIGKTTA ALSQLKTSDSLLDITGPLGMPTEVKQYGTVMVVGGGVGIAAIYPIIKALKEAGNRVITILGARTAELVLLQEECR RYSDELIITTDDGSLGKKGLVTEAMEEVIARESVACSWAIGPSIMMKFCTLTAEKHQLPIYVSLNPIMIDGTGMC GGCRVTVDGTMKFACVDGPEFKGNEVNWDEFINRMKQYQEEEAVCFTDRLKEQVEKNG Enterococcus faecalis NYSGXRC-3504a SGX Pharmaceuticals 2003-11-06 active Selected Cloned Expressed Soluble Purified pir||D75338 ICEDB: T1530 GENBANK NP_814598.1 NSVVNFRDIGGFPTQQGTVVKTGYFFRSGELVNVAQADQQKLVEDYQIKRIYDFRSAAETQERPDDSIQGTNYLHI DILADIQAQTASLEGMLKTVGSPDEAMDMAYKEMVLSNSGRKGYQTFFENFLSYPQEAILFHCFAGKDRTGIGAA LILSALGVEHSYILEDYLKTNEQRKTANEQIIAQYQANGTPLAEIQQLETLLYVKKEYLATALQAIEKEFGSVEG YLKEGLGLPLSAKKDMLSLYTKS Enterococcus faecalis NYSGXRC-3506h SGX Pharmaceuticals 2006-11-28 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB pir||F72730 GENBANK NP_230386.1 PDB 2O16 GKGVRDPGSDGSLRRKELAMIKVEDMMTRHPHTLLRTHTLNDAKHLMEALDIRHVPIVDANKKLLGIVSQRDLLAA QESSLQRSAQGDSLAFETPLFEVMHTDVTSVAPQAGLKESAIYMQKHKIGCLPVVAKDVLVGIITDSDFVTIAIN LLELQEESEPDELDEEQ Vibrio cholerae NYSGXRC-3509f SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble Purified gb|AAF68256.1|AF207065_1 ICEDB: T1665, T1666 GENBANK AAF68256.1 TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQS YVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKA GFERQGTVTTPDGPAVYMVQTRQAFERTRSDA Klebsiella pneumoniae NYSGXRC-3519a SGX Pharmaceuticals 2003-11-04 active Selected Cloned Expressed Soluble gb|AAF06334.1|AF193593_1 GENBANK NP_814214.1 KRKVLFTAVMVLAGLQLLSGCGKTEASANDTVVLRYAYASNSQPVIDSMKKFGELVEEKTDGKVQIEYFPDGQLGG ETELIELTQTGAIDFAKVSGSALESFSKDYSVFAIPYIFDNEKHFFKVMDNQALMQPVYDSTKKLGFVGLTYYDS GQRSFYMSKGPVTSPDDLKGKKIRVMQSETAIKMVELLGGSPVPMGSSEVYTSLQSNLINGAENNEFVLYTAGHG GVAKYYSYDEHTRVPDIVIMNEGTKERLTAKQEQAIEEAAKESTAFEKTVFKEAVEEEKKKAQAEYGVVFNQVDS EPFQKLVQPLHESFKNSSEHGELYQAIRQLAD Enterococcus faecalis NYSGXRC-3519g SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble Purified gb|AAF06334.1|AF193593_1 ICEDB: T1791 GENBANK NP_438315.1 MKLTKLFLATAISLGVSSAVLAADYDLKFGMNAGTSSNEYKAAEMFAKEVKEKSQGKIEISLYPSSQLGDDRAMLK QLKDGSLDFTFAESARFQLFYPEAAVFALPYVISNYNVAQKALFDTEFGKDLIKKMDKDLGVTLLSQAYNGTRQT TSNRAINSIADMKGLKLRVPNAATNLAYAKYVGASPTPMAFSEVYLALQTNAVDGQENPLAAVQAQKFYEVQKFL AMTNHILNDQLYLVSNETYKELPEDLQKVVKDAAENAAKYHTKLFVDGEKDLVTFFEKQGVKITHPDLVPFKESM KPYYAEFVKQTGQKGESALKQIEAINP Haemophilus influenzae NYSGXRC-3527e SGX Pharmaceuticals 2003-11-04 active Selected Cloned Expressed Soluble sp|O34635|SDHB_BACSU GENBANK NP_813901.1 NTAMAINKPKKVNKVMNYKSCFDIIGPIMIGPSSSHTAGALAIGLAARKLFGGTPEKIVIKYYESFADTHKGHGTD FAIIGGILGLAADDANVTQSIELAEEQGIEIQFLEMSEESPVKHANTACVTLSDATHEIHLTGISVGGGTIEVKY IELDGFNVQLHGPLPILLVINQEEQAMQAFKDTLQKNNIQVNAVSRYVEGNQILFIFDLDSAPISSVKEQLFSLD DTSKIILL Enterococcus faecalis NYSGXRC-3538a SGX Pharmaceuticals 2003-09-19 active Selected Cloned Expressed Soluble Purified pir||C81215 ICEDB: T1585 GENBANK NP_814407.1 SKFTEMMKNRRSIYALGENLPISKEEVTALVKEVVRESPTAFNSQTQRVVFLFGDAHKKLWAMTEDALKPLTPAEA FPNTQAKLQGFAAGAGTILFFEDTDIVKNLQDSFPLYADNFPVWSEQATGLTQANVWTALAQENIGANLQHYNPV IDEAVAAEWSIPANWNLRAQMVIGSIEAPAGEKEYMEDSARFKEFN Enterococcus faecalis NYSGXRC-3538c SGX Pharmaceuticals 2003-11-17 active Selected Cloned Expressed Soluble pir||C81215 GENBANK NP_251265.1 SDAFLSSIKNRRTIYALDKQLPVSQEKIVELVKEAVSHSPSAFNSQSSRVVVLFGAEHEQFWNIAKDELKKIVPAD AFAATETKLNSFAAGAGTVLFFEDQTVVRQLQEQFALYADNFPVWSEQASGMAQFAVWTALAEHKVGASLQHYNP LVDAQTHKTWNLPESWKLRAQMPFGAIAAPAGEKAFIAESERFKVFGN Pseudomonas aeruginosa NYSGXRC-3538d SGX Pharmaceuticals 2004-06-08 active Selected Cloned Expressed Soluble Purified pir||C81215 ICEDB: T1792, T611 GENBANK NP_273346.1 TRQSLQQAAESRRSIYSLNKNLPVGKDEVVQIVEHAVLHTPSSFNSQSARVVVLFGEEHDKVWQFVEDALRAVVPA DSFEPTAQKLNLFKAGAATILFYEDQNVVKGLQEQFPAYAANFPVWADQANAMVQYAVWTTLAAVGVGANLQHYN PLPDAAIAKAWNIPENWLLRAQMVIGGIEGAAGEKTFEPVAERLKVFGA Neisseria meningitidis NYSGXRC-3542g SGX Pharmaceuticals 2003-10-09 active Selected Cloned Expressed Soluble Purified gb|AAG04817.1|AE004572_5 ICEDB: T1531 GENBANK NP_414769.1 NNIQIRNYQPGDFQQLCAIFIRAVTMTASQHYSPQQISAWAQIDESRWKEKLAKSQVWVAIINAQPVGFISRIEHY IDMLFVDPEYTRRGVASALLKPLIKSESELTVDASITAKPFFERYGFQTVKQQRVECRGAWFTNFYMRYKPQH Escherichia coli NYSGXRC-3551a SGX Pharmaceuticals 2003-12-10 active Selected Cloned Expressed Soluble Purified sp|Q9ZFV7|EUTS_SALTY ICEDB: T1793 GENBANK NP_815344.1 IQEYVPGKQVTLAHIIASPNKEIYTKLGLPEGTSNALGILTITPSEAAIIAVDIATKSGDIQIGFIDRFSGSVVIS GDVSSVEAALQAVIEGLQQILNFSVTCKITRT Enterococcus faecalis NYSGXRC-3559a SGX Pharmaceuticals 2004-12-10 active Selected Cloned Expressed Soluble Purified emb|CAA74613.1| ICEDB: T1483 GENBANK NP_815000.1 NIFAVRLKEALTAKNIKPSDLAKKTGIGKSSISDWLAGRYEAKQDKVYRIADALDINEAWLMGQEVPMEKNASTID RIYKKLEPQRQAIVYQFAEQQLHEQQTQAEILSFPRRDEMTLAAHAGDPEKIFSKEEIEKIHDYLDEIDAKYQQS ISSDKKED Enterococcus faecalis NYSGXRC-3578c SGX Pharmaceuticals 2003-07-10 active Selected Cloned Expressed Soluble Purified sp|P44990|SGBU_HAEIN ICEDB: T1484 GENBANK AP_004210.1 VRNHQLGIYEKALAKDLSWPERLVLAKSCGFDFVEMSVDETDERLSRLDWSAAQRTSLVAAMIETGVGIPSMCLSA HRRFPFGSRDEAVRERAREIMSKAIRLARDLGIRTIQLAGYDVYYEDHDEGTRQRFAEGLAWAVEQAAASQVMLA VEIMDTAFMNSISKWKKWDEMLASPWFTVYPDVGNLSAWGNDVPAELKLGIDRIAAIHLKDTQPVTGQSPGQFRD VPFGEGCVDFVGIFKTLHKLNYRGSFLIEMWTEKAKEPVLEIIQARRWIEARMQEAGFIC Escherichia coli NYSGXRC-3587c SGX Pharmaceuticals 2003-10-07 active Selected Cloned Expressed Soluble Purified gb|AAG05688.1|AE004655_10 ICEDB: T1532 GENBANK NP_250990.1 IRIDFSQLHQAREDAAAAMPSIAGKKILMGFWHNWPAGAADGYQQGSFANIALEDVPSEYNVVAVAFMKGRGIPTF QPYNLSDAEFRRQVGVLNAQGRAVLISLGGADAHIELHAGQEQALAAEIVRLVETYGFDGLDIDLEQSAIDLADN QRVLPAALKLVREHYAGQGKHFIVSMAPEFPYLHKNGKYVPYLQALEGVYDFIAPQYYNQGGDGLWVQEANGGKG AWIAQNNDAMKEDFLYYLTESLATGSRDFVRIPAQRLAIGLPSNVDAAATGYVIDPAAVSNAFRRLEAAGHAIKG LMTWSVNWDDGLNKRGERYNWEFRKRYASLIHDGEGGDQRPAAPQGLRLLERGETSLVLAWNASSGQRPIDYYSL YRDGAMVGQSAALGSTDSGLTADTRYSYFVTATDTQGNQSLPSEGLEVSTSGGAVDPQFPQWRENQAYRVDDGVT YEGLRYLCLQAHTSNSGWTPPVAFTLWR Pseudomonas aeruginosa NYSGXRC-3596a SGX Pharmaceuticals 2003-10-14 active Selected Cloned Expressed Soluble gb|AAG04742.1|AE004565_1 SHLLELYINFKGEAKEAIAFYEDVFDTKCQNLMTFGEAPEDPEHPINDEIKDLVMNASIIIEGTYVMISDVPDMFG FEVTEGNNLSLVVSTDDDEKIDRLFKRLSEGGTVTMPFLKLFGPKSMVP Enterococcus faecalis NYSGXRC-3597a SGX Pharmaceuticals 2003-10-03 active Selected Cloned Expressed Soluble Purified gb|AAD51075.1|AF175722_1 ICEDB: T1534 GENBANK NP_815878.1 NIQAIDTRHGTANQHSFSNGNCLPYTGVPFGMNFYAPQTTDQKGSWWFHPEDRTFQGYRVTHQPSPWMGDFSHLLM TPVSGSLSELSLFHAQSSYRPEESLFSPVEINLTQLRYQITSQLIPSMYGGILTIDYQQKDNHLLLTLPGRYQVK QLDDHQVAVKVINYSGCEDPDFSFYFVLHFEQPLTKWFAPSSGEDGKILLSFGNIAQQVVHFSSSFISEKQAQLN LAREISLRSTEMLQQGIADWHNYFDRLKVTHENPEHTKTFYHTLYRTFLFPQTFYELDENQQPIHYDTFSQTVRP GVLYTNNGFWDTYKTVYPLFSLIAQEKYEEMLEGFLNSYNETGFLPKWLSPDERGLMPGTLIDAVIADAAVKKIR PDLMPQFLEAMKKGATQQSERENYGRQGTLDYLKYGYVPSTYHESVNHTLDYAYSDFCISQVAKTLNDSETATFY RQQALNYQQLFNPETGFMQAKDTEGNFRPDFLDIRWGKDYAEGSAWQSSFAVYQDFAGLIKLYGSELAFEKKLIQ LCNQAPNFNVEGYGFEIHEMSEMAAIDFGQLAISNQPSFHYPFLFSYIGKPEMAQPLLKQLMQTFDASPTGYPGD EDNGSMSAWYIFNSLGFYPVTPGTGEYVIGMPLVQTAEVKLSNGKQLTIQTSPNKVQQQFIHEIQLNQEKHTAPY FTHQELLNGGTLDYQLGIVPNPQNTAERPFSLSTEK Enterococcus faecalis NYSGXRC-3614d SGX Pharmaceuticals 2003-11-06 active Selected Cloned Expressed Soluble Purified ref|NP_058469.1| GENBANK NP_816291.1 EIGEKLRNLRIQKNLTQEELGERTDLSKGYISQLERDLSSPSMETFFSILEVLGVTPEQFFSQQPLEQKIVYNEEE STLYYDEEHGYELKWLIPASNEKEMEPVIITFDKNGEYKTFEPSLSETFIYVIDGSIRLTLGEATYIAKKGQTMY YQATEPHQISNNGRGKSRALIVATESYL Enterococcus faecalis NYSGXRC-3622d SGX Pharmaceuticals 2003-08-01 active Selected Cloned Expressed Soluble Purified sp|P41780|APBE_SALTY ICEDB: T1442 GENBANK NP_288794.1 EISFTRVALLAAALFFVGCDQKPQPAKTHATEVTVLEGKTMGTFWRASIPGIDAKRSAELKEKIQTQLDADDQLLS TYKKDSALMRFNDSQSLSPWPVSEAMADIVTTSLRIGAKTDGAMDITVGPLVNLWGFGPEQQPVQIPSQEQIDAM KAKTGLQHLTVINQSHQQYLQKDLPDLYVDLSTVGEGYAADHLARLMEQEGISRYLVSVGGALNSRGMNGEGLPW RVAIQKPTDKENAVQAVVDINGHGISTSGSYRNYYELDGKRLSHVIDPQTGRPIEHNLVSVTVIAPTALEADAWD TGLMVLGPEKAKEVVRREGLAVYMITKEGDSFKTWMSPQFKSFLVSEK Escherichia coli NYSGXRC-3622g SGX Pharmaceuticals 2003-11-19 active Selected Cloned Expressed Soluble sp|P41780|APBE_SALTY GENBANK NP_461209.1 KMTFCRAVCLAAAFLLMGCDEAPETTTASPAAQVLEGKTMGTLWRVSVVGIDAKRAAELQTKIQTQLDADDWLLST YKNDSALMRFNHSRSLAPWPVSEAMADIVTSALRIGAKTDGAMDITVGPLVNLWGFGPDRQPLHIPTPAQIDAAK AKTGLQHLQVIDRAGHQFLQKDLPDLYVDLSTVGEGYAADHLARLMEQEGIARYLVSVGGALSSRGMNAQGQPWR VAIQKPTDRENAVQAIVDINGHGISTSGSYRNYYELDGKRVSHVIDPQTGRPIEHNLVSVTVIAPTALEADGWDT GLMVLGTQKAQEVVRREGLAVFMIMKEGEGFKTWMSPQFKTFLVSDKN Salmonella typhimurium NYSGXRC-3647a SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified pir||F82277 ICEDB: T1537 GENBANK NP_816917.1 SSVYTMKRIWLQKDKKAYQAWRELMEKAELQTTEALDYTVGIYDDTALIASGSLSGKTIKCVAVCKKYQSENLLTQ LVVHLLEKLREENQLHSFLYTKPKNEQIFQSLGFQKVVANQEVLFMEQGKPDFADYLGYLTQHKKAGPASSIVMN ANPFTKGHQYLVEKAAQESPHVYVFVLSEDKSLFSKEARFAMVQKGVAHLPNVTVLSTEDYLVSSATFPTYFLKE KAPLEVAAIQATLDATLFKERIAPILEIQQRYVGEEPYSEVTAVYNQAMQQVFGQTITLTIVPRLASDGELISAT KVRKAMAEGDKETLKKFLPATSYQYLVEHKKL Enterococcus faecalis NYSGXRC-3650e SGX Pharmaceuticals 2003-11-06 active Selected Cloned Expressed Soluble Purified pir||C69774 ICEDB: T1538 GENBANK NP_816572.1 RKEFPLMNRLKELRKEKNITLVELSEELGIPRSTLNRYENEDSEPKQETWEKLADYYGVSTAYLMGISNQKVSEEK ALTAAKKVYQVYLSDDDLGKEIRKALMYFNKNDLDSVLKQAMQQYFTIPAVEWNTEFQSLKNTGFLYSWLEGYLV DRYRKEVKTNHNLITNTYYSIPSIDDVNEYGIFSDEIQIPLTEDFKQIFKVEDLSTKTHEEIKKLFKSDSTLIAY SYESSVDDKLKDDINMILDNARSEILNLKEKYPDKPSRIEQTTVLISKDEDTSFWSRNGSNDYIDELNLSEETKK LFVHLGSVFIEEKKRKSKAKE Enterococcus faecalis NYSGXRC-3656a SGX Pharmaceuticals 2003-11-04 active Selected Cloned Expressed Soluble gb|AAF12710.1|AF066865_8 GENBANK NP_813932.1 TYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEA GQNIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERK Enterococcus faecalis NYSGXRC-3660a SGX Pharmaceuticals 2003-08-27 active Selected Cloned Expressed Soluble Purified sp|P77174|YBDM_ECOLI ICEDB: T1634 GENBANK NP_814365.1 NKIDMPVLNVKMVPVEKIKSNSYNPNHVAGPEMELLELSILKDGYTQPIVCYCDDKKDEYIIIDGFHRYLIGKSKL DLKELPVVVIDKPLEQRMSSTIRHNRARGKHEIDKMSELVLLLVNEGWDDHKIGKELGMEKEEVLRLKQVTGLKS AFLNHEFSESWDEFVKKNYPKQKDE Enterococcus faecalis NYSGXRC-3816a SGX Pharmaceuticals 2003-09-26 active Selected Cloned Expressed Soluble Purified DR2220 ICEDB: T1586 GENBANK NP_295942.1 MGFFNKLRQLAEDGTKMAQDGYARFNNAAFADATMAACALIGAADGQIDSQERSRTAQFITSSDKLRTFDVSKLRE KYERYCDVISRDFDFGKIELMQVIGKVRKPEEARAVVQLAVVIANADGDFDAREQAVMREVIHALGLSPAEFGL Deinococcus radiodurans NYSGXRC-3820d SGX Pharmaceuticals 2006-10-27 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB wlaI ICEDB: T1635 PDB 2NPO GENBANK NP_282271.1 PFAM PF00132 MARTEKIYIYGASGHGLVCEDVAKNMGYKECIFLDDFKGMKFESTLPKYDFFIAIGNNEIRKKIYQKISENGFKIV NLIHKSALISPSAIVEENAGILIMPYVVINAKAKIEKGVILNTSSVIEHECVIGEFSHVSVGAKCAGNVKIGKNC FLGINSCVLPNLSLADDSILGGGATLVKNQDEKGVFVGVPAKRM Campylobacter jejuni NYSGXRC-3821d SGX Pharmaceuticals 2003-10-03 active Selected Cloned Expressed Soluble Purified NMB1020 ICEDB: T1539 GENBANK NP_274054.1 MTYEKLYELRQTLRPTTKDGLYTDNEKNREILTVRWSGNTENPKNFSAVAIGINPSKANDERSDKTLTQLARFLDM YGFTNFKMLNIFSSYSTQQTGIRANTQTDFSKFKGCLEDADMIILAWGTDRGAYKDEKNRILEFLKAEKFMEKVF CISETGNSSDTRHPSRISYSYQLVQFEESA Neisseria meningitidis NYSGXRC-3822g SGX Pharmaceuticals 2003-12-03 active Selected Cloned Expressed Soluble Purified VCA0455 GENBANK NP_232847.1 MCMEAVMNIGIYIYDEAEVLDFSGPFEVFSTAKRLGAGSWNVFLVSETLEPVKARGGFTVLPDYSFQNYPQIDLLI VVGGVHRNEMNKSNVLHWVASVDKHAKHIASVCTGAFILANAGLLKGLAVTTHWEDIPELKQRFPDLVVVEDKRW ITASKYTTSGGISAGIDMSLFLVSKFHSQSHAELVAHQMEYNWQKCT Vibrio cholerae NYSGXRC-3825b SGX Pharmaceuticals 2003-09-25 active Selected Cloned Expressed Soluble Purified TM0660 ICEDB: T1495, T1639 GENBANK NP_228469.1 MIGFLTDWGLKSHYVGVAKAVIKRINPSAEIIDITHEVEPFNVRKASHVLYRASLDFPPSTVFLVVVDYGVGTSRK AIVMKTKNDQYFVAPDNGVLTVVAEEYGVAEIREIENRELFYKKNPSFTFHGRDIFAPVAAHLDMGLPLERVGDR LLSYEVLKMRKPVVENEKVIGEVAIVDTFGNVSTNIPFDLFLKLSVDFDDVVRVRVGRKEFKAAVAKAFGDVDTG ELLVHPDSAGFLEIAVNLGDASQVLSVKEGDEIEICR Thermotoga maritima NYSGXRC-3825d SGX Pharmaceuticals 2003-09-26 active Selected Cloned Expressed Soluble Purified PH0463 ICEDB: T1636 GENBANK NP_142440.1 MITLTTDFGLKGPYVGEMKVAMLRINPNAKIVDVTHSVTRHSILEGSFVMEQVVKYSPKGTVHVGVIDPGVGTERR AIVIEGDQYLVVPDNGLATLPLKHIKVKSVYEIIPDKIRKFTGWEISSTFHGRDIFGPAGALIEKGIHPEEFGRE IPVDSIVKLNVEPRKEGDVWILKVIYIDDFGNVILNLENYEKPRTVELLDFNLRLPYLETYGLVEKGEMLALPGS HDYLEIAVNMGSAAERLNVKVGDELRVRLL Pyrococcus horikoshii NYSGXRC-3825e SGX Pharmaceuticals 2003-11-18 active Selected Cloned Expressed Soluble Purified AF0461 ICEDB: T1641 GENBANK NP_069297.1 MKVVSLLTDFGDFYPGVMKGVILSLAPEARIVDITHSVEPQNILQGAFLLYHSFRYFRNAVHVAVVDPGVGSERRA LVIEGKNHFFVGPDNGILYPSAVEDGIKAAYSIKEEISELVGELSSTFHGRDIFAPAAAMVVRGDYTYFEEINKE ELEKLELFDCSIQGNKVRCRVVYVDRFGNVVTNLREVKGKGFYFRGVEFPFVKTYSDVDVGKPLSLIGSFGTLEL SVREGSAAEMLGIKRGGGWIELEVL Archaeoglobus fulgidus NYSGXRC-5734k SGX Pharmaceuticals 2004-07-26 active Selected Cloned Expressed Soluble Purified murE ICEDB: T1856, T2095, T56 GENBANK NP_374139 LDASTLFKKVKVKRVLGSLEQQIDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQGCKLVVVNKEQSLPANV TQVVVPDTLRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATMIHLIQRKLQKNSAYLGTNGFQINETKTKGAN TTPETVSLTKKIKEAVDAGAESMTLEVSSHGLVLGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQL GEDLSKEKYVVLNNDDSFSEYLRTVTPYEVFSYGIDEEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKFN ISNIMAAMIAVWSKGTSLETIIKAVENLEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFL VGMAGERDLTKTPEMGRVACRADYVIFTPDNPANDDPKMLTAELAKGATHQNYIEFDDRAEGIKHAIDIAEPGDT VVLASKGREPYQIMPGHIKVPHRDDLIGLEAAYKKFGGGPVDQ Staphylococcus aureus NYSGXRC-5734p SGX Pharmaceuticals 2004-07-26 active Selected Cloned Expressed Soluble Purified MurE ICEDB: T1857, T2096 GENBANK NP_722010.1 MITIETVLTILKNNANFREIIDGKHYQYKYSNPEVAFHHISYDSRDIKASTLFFVKGATFKKEFLEKAIESGLTFY VAEKDYQVGIPLILVNNIKNAMCLIAKEFYDNPQDKLKTLAFTGTKGKTTAAYFAYHILKQGYRPAMISTMNTTL DGKTFFKSKLTTPESLDLFKMMAQAVANGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNISPDHIGPIEHPTFED YFYHKRLLLKHSRYVIVNSQMNHFALIKEQVADQPHDFYGKYSDNQIINSKAFSFDLTGKLAGHYDIQLTGSFNQ ENAVAAALACLQLGASQTDIQKGIVQTTVPGRMEVLIQKNGAKVFVDYAHNGDSLEKLLSVVEEHQKGTLILILG APGNKGESRRADFGYVINAHPELQVILTADDPNNEDPQLISQEIAHHIKRPVNIIVDRKQAIQKAMSLTQSENDA VIIAGKGADAFQIIKGKRTAYAGDIEVARKYL Streptococcus mutans NYSGXRC-5774a SGX Pharmaceuticals 2003-09-23 active Selected Cloned Expressed Soluble ECs0173 GENBANK NP_308200 MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVG DHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDSYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACL RGIEIEADVVLKATKVDGVFTADPAKDPTATMYEQLTYSEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGAL RRVVMGEKEGTLITE Escherichia coli O157:H7 NYSGXRC-5774h SGX Pharmaceuticals 2003-10-08 active Selected Cloned Expressed Soluble Purified pyrH ICEDB: T1638 GENBANK NP_358439.1 VKMANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQAD YTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALR AAEIEADAILMAKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNI KRVVFGENIGTTVSNNIEEKE Streptococcus pneumoniae NYSGXRC-5779l SGX Pharmaceuticals 2003-12-02 active Selected Cloned Expressed Soluble Purified TM1466 ICEDB: T1795 GENBANK NP_229266.1 MIIRDVELVKVARTPGDYPPPLKGEVAFVGRSNVGKSSLLNALFNRKIAFVSKTPGKTRSINFYLVNSKYYFVDLP GYGYAKVSKKERMLWKRLVEDYFKNRWSLQMVFLLVDGRIPPQDSDLMMVEWMKSLNIPFTIVLTKMDKVKMSER AKKLEEHRKVFSKYGEYTIIPTSSVTGEGISELLDLISTLLKEN Thermotoga maritima NYSGXRC-6000a SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed Soluble HI0004 MGSVLVDLQIATENIEGLPTEEQIVQWATGAVQPEGNEVEMTVRIVDEAESHELNLTYRGKDRPTNVLSFPFECPD EVELPLLGDLVICRQVVEREASEQEKPLMAHWAHMVVHGSLHLLGYDHIEDDEAEEMESLETQIMQGLGFDDPYL AEK Haemophilus influenzae NYSGXRC-6000c SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0004 MPLELDLQVASAAPDLPSEAQFRAWCELALRQRPESELTIRLVDEAEGLELNSTYRHKDYATNVLSFPADVPDELL DIPLLGDLVICAPVVAREALEQRKPLQAHWAHLVIHGCLHLLGYDHIDDAEAEEMETLERELLAELGHPDPYACD DEEPPSKEK Pseudomonas aeruginosa NYSGXRC-6000d SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed Soluble HI0004 MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVTIVSNDDIHQINKEYRGKDAPTDVISFALEEEG EGEIEIVGAEMPPVLGNIIISADRTREQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDA YGLKRS Bacillus subtilis NYSGXRC-6000e SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed Soluble HI0004 MDITFIDETEKVPTEEIKEIENLLQFAAGFLEIAEDTEMSVTFTDNAGIQMINRDYRGKDMPTDVISFALEDEGED ELPIIFDDEELAELPRNLGDLIISTERAAEQAVEYGHTLEREMGFLAVHGFLHLNGYDHMEPEDEKEMFGLQKEI LDAYGLKR Enterococcus faecalis NYSGXRC-6000f SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0004 MFTIDFSDHTGLVKDAWYKQIEDLLEFAKKEEHIEDDAELSVTFVDKQEIQEINRTYRDKDKVTDVISFALEEDEP EIDFSGLDIPRVLGDIIICTDVAQEQANNYGHSFERELGFLALHGFLHLLGYDHMTEADEKEMFGRQDTILNAYG LTRD Staphylococcus aureus NYSGXRC-6000g SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed Soluble HI0004 MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVTNERSHELNLEYRDTDRPTDVISLEYKPELEIA FDEEDLLENPELAEMMSEFDAYIGELFISIDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFG LQEEILTAYGLTRQ Streptococcus pneumoniae NYSGXRC-6000h SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0004 VREHLMSIEVANESGIDVSEAELVSVARFVIAKMDVNPCAELSMLLLDTAAMADLHMRWMDLPGPTDVMSFPMDEL EPGGRPDAPEPGPSMLGDIVLCPEFAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHAEPDEEKEMFALQDRLLE EWVADQVEAYQHDRQDEKDRRLLDKSRYFDL Mycobacterium tuberculosis NYSGXRC-6000j SGX Pharmaceuticals 2003-03-11 active Selected Cloned Expressed Soluble HI0004 ICEDB: T844 GENBANK NP_207951 MLEIDNQTPLESDFLLLEKIANVLAPTQIIELVLVSDETIREINKDLRGCDYATDVLSFPLEAIPHTPLGSVVINA PLAQTNALKLGHSLENEIALLFIHGVLHLLGYDHEKDKGEQRQKESELIKAFNLPLSLIERTQD Helicobacter pylori NYSGXRC-6000k SGX Pharmaceuticals 2003-02-28 active Selected Cloned Expressed Soluble Purified HI0004 ICEDB: T848 GENBANK NP_455237.1 MSQVILDLQLACENHAGLPDEAQFQRWLDGVIPQFQEEAEVTIRLVDEAESHDLNLTYRGKDKPTNVLSFPFEAPP GIEMPLLGDLIICRQVVEQEAQEQSKPLEAHWAHMVVHGSLHLLGYDHIDDDEAEEMESLETEIMLAMGYEDPYI AEKIAE Salmonella typhi NYSGXRC-6000l SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0004 GENBANK NP_230607.1 MSIELDLQLAVENEHGLPSEAEFALWLTRTITPFQAQAEVTVRIVDEAESHALNLNYRGKDKPTNVLSFPFEAPSG MEMDLLGDLVICRQVVEREAIEQNKPLQAHWAHMVVHGSLHLLGYDHIEDDEAEEMESLETEIMQEMGFTDPYLA EKE Vibrio cholerae NYSGXRC-6000m SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0004 MTRGPIFLNVGISYGLPRTKLPAAVSFRKWVAATLQGRIRKADLAIRIVDEKEGRALNYHYRNKDYATNVLSFPAQ LPEPLPKALKIPLLGDIVMCAPVIAREAAEQGKSLSAHYAHLTVHGTLHLLGWNHEDHQEADAMEQLEREILANL GISDPYLEEY Xylella fastidiosa NYSGXRC-6000n SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0004 VAKPKKTQPAATAPRVDVFDAKGKPKTVDASALRIAFADGRSLLVSLPDTADGAITLVAEHADAATHAMLALRPEH HDSITLRIEAEPAAEAEDADDALAGAEMLTLDLTVQHGDALKAAARKALPKQKDIEAWIAPALFADAQLNVRFVD EEEGRTLNHTYRGKDYATNVLTFSYAETEDDPVAADIVLCCPVVEQEAKDQGKPLRAHYAHLIVHGALHAQGYDH EDPAQAEEMEGIETEVLAGLGFPDPYADR Ralstonia solanacearum NYSGXRC-6000o SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0004 GENBANK NP_353390 MRAFRRATDVKTMAALDIQISVEAEGWSSEENLAAFATKVLNAAVDFLKREEEQPFPKMPVELSLVFTDDENIREI NAEWRDKDKATNVLSFPAFPLEPGGMPGPMLGDIVIARETVEREALELDKSFEDHLTHLLVHGFLHLFGYDHMDE EEAEEMESLETRILAVLGLSDPYAGQEPL Agrobacterium tumefaciens NYSGXRC-6001a SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0045 GENBANK NP_438218.1 MKKQILALVCGVIFSSSTWAHNLQLEQSLPSVKVSEYGEIVLSGKDTVFQPWGSAELAGKVRVVHHLAGRTAAKEN QSMIDVIKASHFNPVKYQTTTIINADDAIVGTGMFVKNGAKKGKQENPHSQVVLDDKSAVKNAWGLNSKDSAIIV LDKTGKVKFVKEGKLSDSDIQTVISLVNGLTK Haemophilus influenzae NYSGXRC-6001b SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0045 GENBANK NP_463266.1 MTLRKILAMSCLLLPIMACAHNLEVNQRVPPVGIADRGELTLNKDEFSYKNWNSAQLAGKVRVLLHIAGRTSAKEK NATLIEAIKSAKLPHDRYQTTTIVNTDDAIPGSGMFVRSSIESNKKLYPWSQFIVDSNGVARNAWQLKEEGSAVI VLDKDGRVQWVKDGALTQQEVQQVVDLLHKLLSK Salmonella typhimurium NYSGXRC-6001c SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0045 GENBANK NP_839663.1 MTLRKILALTCLLLPMMASAHQFEIGQRVPPIGITDRGELVLDKDQFSYKTWNSAQLVGKVRVLQHIAGRTSAKEK NATLIEAIKSAKLPHDRYQTTTIVNTDDAIPGSGMFVRSSLESNKKLYPWSQFIVDSNGVARGAWQLDEESSAVV VLDKDGRVQWAKDGALTPEEVQQVMDLLQKLLK Shigella flexneri NYSGXRC-6001d SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0045 GENBANK NP_232178.1 MKNKTLIALLLACSPTLAFAHNLTVGSPVPAVGVEKHGEIVLQDNNINYQKWRSADLLGKVRVIQAIAGRSSSKEM NAPLMAAITAAKFPAESYQTTTIINQDDAIWGTSSFVKSSAQDSKKEFPWSSMVLDEFGLVAQAWQLQAESSAII VQDKQGNVLFVKEGALNEADIQTVLGLIQQNL Vibrio cholerae NYSGXRC-6002a SGX Pharmaceuticals 2003-03-11 active Selected Cloned Expressed Soluble HI0081 ICEDB: T859 GENBANK NP_438254.1 MHFFDTHTHLNYLQQFTGEPLSQLIDNAKQADVQKILVVAVKEADFKTIQNMTALFPDNLCYGLGLHPLYIQEHAE NDLILLEQALKNRDTNCTAVAEIGLERAIPDLLTDELWAKQCHFFESQLYLAKQFNLPVNIHSRKTHDQIFTFLK RIPLSKLGVVHGFSGSYDQAKRFVDLGYKIGVGGTITYERANKTRQAIAKLPLDALVLETDSPDMPVFGFQGQPN RPERIVESFKALCTLRNEPAELIKKLTWENACQIFS Haemophilus influenzae NYSGXRC-6002b SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed HI0081 VQALAENYQPLYAALGLHPGMLEKHSDVSLDQLQQALERRPAKVVAVGESGLDLFGDDPQFERQQWFLDEQLKLAK RYDLPVILHSRRTHDKLAMHLKRHDLSRTGVVHGFSGSLQQAERFVQLGYKIGVGGTITYPRASKTRVVIAKLPL ASLLLETDAPDMPLNGFQGQPNRPEQAARVFDVLCELRPEPEDEIAEVLLNNTYRCLTFVGSLVGSIRQSAHNA Escherichia coli O157:H7 NYSGXRC-6002c SGX Pharmaceuticals 2003-07-22 active Selected Cloned Expressed Soluble Purified HI0081 ICEDB: T858, T862 GENBANK YP_691687.1 LICRFIDTHCHFDFPPFIGDEEASLQRAAQAGVGKIIVPATEAENFARVQALAENYQPLYAVLGLHPGMLEKHSDV SLEQLQQALERRPAKVVAVGEIGLDLFGDDPQFERQQWLLDEQLKLAKRYDLPVILHSRRTHDKLAMHLKRHDLP RAGVVHGFSGSQQQAERFVQLGYKIGVGGTITYPRASKTRDVIAKLPLASLLLETDAPDMPLNGFQGQPNRPEQA ARVFAVLCELRPEPADEIAEVLLNNTYAVFNVRG Shigella flexneri NYSGXRC-6002d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0081 MNVVLIDSHCHLDADAFDGDRAEIIARAQAAGIIAQVIPAVTAAKWPKLRTICTQTSGLYPAYGLHPMFLTEHHPT HLHALRDWLEHERPCAIGECGLDFYLEGLNREMQHTYFIRQLMLAREYALPVIVHARHAVEEVIASIKTVGTLRG VVHSFSGSLEQARQLWKLGFMISLGGAMTYPRAHRLHQLAMETPLDCLLLETDAPYQPDSEIRGKRNEPGRLLTI LDYIATLRKQDRTEISKVTRANTEQLFGLKVTPT Xylella fastidiosa NYSGXRC-6002e SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0081 GENBANK NP_109697 MEYFDAHCHLNCEPLLEQHEKSLANFRLIGLKANVVGTNLTNSQIAVNLAKQHPDLLKAGVGIHPNDVQLFDLKAA QATLKKLVSTHRSFISCIGEYGFDYHYTKDYITQQEQFFLMQFQLAEQYQLVHMLHVRDVHERIYEVLKRLKPKQ PVVFHCFSEDTNTALKLLTLREVGLKVYFSIPGIVTFKNAKNLQAALSVIPTELLLSETDSPYLAPVPFRGKTNP ECVVHTVQTIADIKQVPLAEIKQAIVHNAKKLFW Mycoplasma pneumoniae NYSGXRC-6002f SGX Pharmaceuticals 2008-02-20 active Selected Cloned Expressed Soluble Purified Crystallized HI0081 ICEDB: T861 GENBANK NP_274691.1 MNFTDTHCHLADPALRENLPHILTAARKVGVKRFIVPATRPQDWQDVADLAEMPSEHGQIRIALGIHPWFSDGIAE RDFVRLETMLAHYPQAWVGEIGLDFYDKTQTSQQRERQIQVFVRQLEIAQTLRRRVIIHNLKATADIAAAVKQTG FAQGGIVHAFSGSAEEARVLTKLGFKIGIGSLLLNPNARKVRDTLKALNDGDFVLETDSPFMLKKEINTPANIPG IAKIAAEIRGTCVEEIAKVTERNADALLGR Neisseria meningitidis NYSGXRC-6003a SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0117 VPVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVL MTGYYSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGN LNYFAYAGQNGYPYTAIGRLLVEDGEIPKEKMSIQAIREWGNRNPSRIQSLLERNEAYVFFKNDPSGKVKGSAGV PLVAMASVASDRNIIPSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSK HYGRVWVLR Haemophilus influenzae NYSGXRC-6003b SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0117 GENBANK AAC75855 MKGRWVKYLLMGTVVAMLAACSSKPTDRGQQYKDGKFTQPFSLVNQPDAVGAPINAGDFAEQINHIRNSSPRLYGN QSNVYNAVQEWLRAGGDTRNMRQFGIDAWQMEGADNYGNVQFTGYYTPVIQARHTRQGEFQYPIYRMPPKRGRLP SRAEIYAGALSDKYILAYSNSLMDNFIMDVQGSGYIDFGDGSPLNFFSYAGKNGHAYRSIGKVLIDRGEVKKEDM SMQAIRHWGETHSEAEVRELLEQNPSFVFFKPQSFAPVKGASAVPLVGRASVASDRSIIPPGTTLLAEVPLLDNN GKFNGQYELRLMVALDVGGAIKGQHFDIYQGIGPEAGHRAGWYNHYGRVWVLKTAPGAGNVFSG Escherichia coli NYSGXRC-6003c SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0117 GENBANK NP_249913.1 VKFPFHPWRRLLLCALPFAALLTACDDGKKEPPPKPAEVTTYNSVPWDALPATSDADLLAGFNAWRSACARLAKDP VWGEPCASATTVAADPTAVRAFLQERMQVYSLRSSSNGDQGLITGYYEPVYHGSLSQGEKTPVPVYGVPDDLVVV ALESVYPELKGKRLRGRLEGRVLKPYDDAATIRDNGSSAPVLAWLGDPMDLQFLQIQGSGRIQLEDGRQLRIGYG DQNGHPYKPVGRWLVEQGLVPKEEISMKRIRDWAEANPQRVSELLASNPSFVFFSLRPDSDEGPRGSLNVPLTDG YSVAIDRKVIPLGSLMWLSTTRPDDGSAVVRPVAAQDTGGAIVGEVRADLFWGTGDAAGELAGHMKQPGRLWLLW PKGAPLPAS Pseudomonas aeruginosa NYSGXRC-6003d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed HI0117 MAGIKKILMFSLILIFLAACVSPELEEKLNNLENQIRQLNTQIDSIEKKMLDLENKMKAQESSQEELEALKRDVRY LKEDLSSLQEEFSSKMSDLENSYYSISMKLPAVEKAASIFSEIEDMKSKISELERKVSIVSLGSSPEVSEDLKHI LLDLEERVSTLEKNVSVVDRIEERLESTEKLLSKVALRVLSQGETEAKVVNVSNDELESRISDIEKKLSYLETNQ KALEQIVQNLKDQKPSSYANIDVESYSQQLKKYLDEFRRLVRSYEIARILGIEEGYVFVRVERGDTLAKISNAFN LGPDGVEKIMKLNGIDDPRKLIAGRIIKVPVTNLSTSFPVGEKPDPKVIVSGFGLKTDGTFSTGVEVESDGQKVK AALPGRVKSVSNGTVVIYHGNDVETVYRNLAVVSVNAGDWVSAGDTIGYGGKNVVFELYVEGEPKDPMLLFFSNM GEFEISFYTEWEDGKLPEHPAFRLTKSGKIPEDWKTAAADTTIFPLGSVLYIPELRDTPSGGVFVVEDIGGVIMG RKIDIYLDSIREALQNRKIVSRVFVWRD Thermotoga maritima NYSGXRC-6003f SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0117 GENBANK NP_231943.1 VSKRLLSLASLALLFGCAQQPNDRAQQYQQQTFPHILNRADVVESNKPRDYTEFSKQSELVVQGSASMAKIYRPLY EQLNEWVLQSGDPATLAQFGIQAAQLGGGDKQGNVLFTGYFSPVIELRHQPDSVFKYPVYGLPKCNKNCPTRAEI YQGALDGQGLELGYAENLIDPFIMEVQGSGFVHFGDDDTLEYFAYAGKNNKAYVSIGKVLIERGLVEREKMSLKA IKDWVLANDEATVRELLEENPSFVFFKPSAAAPVKGSAGIPLLPMASVAGDRSILPMGTPILAEVPLLNADGTWS GAHQLRLLIVLDTGGAVKQNHLDLYHGMGPRAGLEAGHYKHFGRVWKLGLENSPTQAPWALPPEKQQ Vibrio cholerae NYSGXRC-6003g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0117 MTATTLDASTRAHTVHRRGWAGLSAALVAVLLAACTSGPPPRLEAPQAPTATLGGGLQPATWADVAGWTTDDLASA WPALQSNCLAMKRRADWARVCAAGLMVDAGDPIAMRTFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHG VYQTPLYRMPAAWRGKTLPARVQLIRSPALAGNEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPF RSFARWLLDQGEITPVQATMQGIKAWARANPGRVDEMLNINPRYVFFNENPGNSDGPIGKLGVPLTAERSIAVDP GYIPLGAPVFLSTTKPLSTEPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGSPVG VASR Ralstonia solanacearum NYSGXRC-6003h SGX Pharmaceuticals 2003-01-30 active Selected HI0117 MIRKTLALFSLSLGIALVNPIAVAQVIDVPSPLPSNPQLPSPVTRTPLKLVEIGNNCVTQNPCLGFDEQIFGVGRA SDRKALLAAIDNSLRYLQTNTAKRIYQNYPVRGITLSRVRRSLLRFRQLVVNSRTPAQLQAAVRREFAFYQSVGN DGKGTVKFTSYYQPVYRASRVRTSVYKYPLYRLPSNFQQWSKPHPTRLELEGEDGLQGHTGPLRGSELLWFSDRL DAYMVQIQGSAQIQLTNGQRTAIGYAGGTDYPWTSIGRELAKDGKLPLSGMTMPKMISFFRQQPEELNNYLPRWE RFVFFQETGSRPATGSINVPVTPERSIATDKSLMPPGALALVHTSIPFPVAGGRMEYRTVSRYVLDQDTGNAIKG PGRVDYFMGTGKQAGDRAGVTGGHGSLYYLLLRK Nostoc sp. NYSGXRC-6003i SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0117 GENBANK NP_353049 MNTPFSIDEVSFRDLPGWGQDDPRKLFPAMATILSHLRNAKPYRTGALGITAAELVSLLELAERGQVNSPEQARQF FETNSVPFRISPAQGKSGFVTAFYEPELEVSATPDDVWRYPIYRRPPELVDIDNDNRPDGFDPSYAFGKADEEGI SYFPDRRAIDEGCLRGRGLEIAWARSKVDLFFVHVQGAARLVFPDGAIKRITYAAKAGHVFSPIGRLLLDRGELD PKTISMQTIRQWLADHPDEVDGVLWHNRSYIFFREADVAGLDMGPIAAAKVPLVAGRALAVDRLIHTFGLPFFIH APTLTHLDDGKPFARLMLALDTGSAIVGPARGDIFTGSGFEAGELAGTVRNEADFYILLPRIAAERYRR Agrobacterium tumefaciens NYSGXRC-6003j SGX Pharmaceuticals 2003-02-17 active Selected Cloned HI0117 GENBANK NP_422534.1 MTRLAYTSLAPLALAAVLSACASTPATTPPPAAVSAPTPAPAPPSVQAPVASAPQSAMPAALSFAGLAGWAEEDHL AALNAFRAGCGVSKDPAAARVCGLAKATKDLDVSGAKAFIEANFRVEAVDGGGDGLLTAYFAPQYEARMSRNAEF SAPLRGLPADLVVLDLGPFEPALVGKKITGHVEGSTFVPYPDRAEIEATPSDKPLAWMRPEELFFLQIQGSGVLV LPDGRRVRAVFAGTNGKPFVGIAIAMRDKGLLPDNNTSADAIRTWLAEHRGPEADAIMRLNPRYVFFRTVPDDGK EPAGAAGVALPPGRAIAVDPGYHAYGGFYWLDAAAPKLVGAFPVYRRAVTALDTGGAIKGEVRADLYMGSGAVAG VEAGRVRHTLRLYRLTPNP Caulobacter crescentus NYSGXRC-6004a SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0131 GENBANK NP_438300.1 MKFNKISLSVSTALLAAGLAVSGSANAKGRLVVYCSATNILCETTTKAFGEKYDVKTSFIRNGSGSTFAKVEAEKN NPQADVWFGGTFDPQAQAAELGLIEPYKSKHIDEIVERFREPAKTKGHYVSSIYMGILGFGVNTERLAKLGIKEV PKCWKDLTDPRLKGEVQIADPQSAGTAYTALATFVQLWGEKEAFDFLKELHPNVSQYTKSGITPSRNSARGEATI GVGFLHDYALEKRNGAPLELVVPCEGTGYELGGVSILKGARNIDNAKLFVDWALSKEGQELAWKQGDSLQILTNT TAEQSPTAFDPNKLKLINYDFEKYGATEQRKALIEKWVQEVKLAK Haemophilus influenzae NYSGXRC-6004b SGX Pharmaceuticals 2003-02-17 active Selected Cloned Expressed HI0131 GENBANK NP_286103 MKMTFTSTLIASAVALATLTGAAQAKGRLVVYCSATNEMCEAETKAFGEKYDVKTSFIRNGSGSTLAKVDAEKKNP QADVWYGGTLDPQSQAGEMGLLQAYKSPNLEQIMEKFRDPAKVKGNLSSAVYVGILGFGVNTDRLKEKNLPVPKC WKDLTKPEYKGEIQIADPQSSGTAYTALATFAQLWGEDQAFDYLKQLNANVSQYTKSGIAPARNAARGETAIGIG FLHDYSLEKEQGAPLELISPCEGTGYEIGGVSILKGARNLDNAKLFVDWVLSKEAQELAWKKGKSYQILTNTTAE TSPNSLKLDDLKLINYDMDKYGSTDVRKALINKWVSEVKMGK Escherichia coli O157:H7 NYSGXRC-6004c SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0131 GENBANK NP_233073.1 MIVNAKRTLLALSVLGSMMTAPLVHAEGRLVVYCSATNAMCEAGTKAFAEKYNVNTSFVRNGSGSTLAKIDAEKNN PRADVWYGGTLDPQSQAGEMDLLQAYQSPELANIMEGFRDPAKRKGNYSSAVYMGILGFGVNTERLAQKGIPIPR CWADLTKPEYKGEIQISDPQSSGTAYTALATFIQLWDEPTAFEYFKKLDKNVSQYTKSGVTPSRNSARGEVAIGI GFLHDYSLEQAKGAPLELISPCEGTGYELGGVSIIKGARNLDNAKLFVDWVLSKEGQEVAWKQGDSYQILTNTQA EQSPNALDPKTLKLINYDMETYGSSDERKRLITKWVNEIKMGN Vibrio cholerae NYSGXRC-6004d SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0131 GENBANK NP_355880 VERRSHVRRLIQTQTMEEIMRLTIISSLLLAGTTLLGVPAHAAGDLNLICAADVVICEQMKGDFEKTHDIKVNMVR MSSGEAYAKIRAEARNPKTDLWWAGTGDPHLQAASENLTLEYKSKMLDQLQDWAKNQAESAGYKTVGVYAGALGW GYNTDIFKKKGYKEPKCWADLLAPELKGEIQIANPNSSGTAYTALASLVQIMGEDQAFDYLKKLNGNISQYTKSG SAPVKAAARGETAVGIVFMHDAVAQTAEGFPVKSVAPCEGTGYEIGSMSIVKGARNLENAKTWYDWALQPDVQSR MKDAKSFQLPSNKTAEIPKEAPRFEDIKLINYDFKTYGDPEKRKALLERWDKDVGAAAN Agrobacterium tumefaciens NYSGXRC-6004e SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0131 MKRLIHWLRACGLVAAGALAMAAPLHAQPAGQQVAICYNCPPEWADWAGQIQAIKNRTGIAVPFDNKNSGQAIAQM LAEKGHPVADVAYLGITSAYQAKEKGLVAGYKPKHWDDIPAGMKDPDGAFFSIHSGTLGFFVNKDALEGKPVPRS WKDLLKPEYKGMVGYLDPSSAFVGYVGAVAVNQALGGTLDNFGPGIDWFKQLKKNAPIVPKQTAYARVVAGEIPI LLDYDFNAYRAKYKDHANVEFVIPQEGSIAVPYVMSLVAGAPHADNAKKVLDFVLSDEGQALWANAYLRPVRAGA MSKEAAARFLPASEYARVKTVDFNQMAARQQAFGTRYLDEVR Ralstonia solanacearum NYSGXRC-6005a SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0148 GENBANK NP_438317.1 MGFIMKLTKTALCTALFATFTFSANAQTYPDLPVGIKGGTGALIGDTVYVGLGSGGDKFYTLDLKDPSAQWKEIAT FPGGERNQPVAAAVDGKLYVFGGLQKNEKGELQLVNDAYRYNPSDNTWMKLPTRSPRGLVGSSGASHGDKVYILG GSNLSIFNGFFQDTVAAGEDKAKKDEIAAAYFDQRPEDYFFTTELLSYEPSTNKWRNEGRIPFSGRAGAAFTIQG NELVVVNGEIKPGLRTAETHQGKFTAKGVQWKNLPDLPAPKGKSQDGLAGALSGYSNGHYLVTGGANFPGSIKQF KEGKLHAHKGLSKAWHNEVYTLNNGKWRIVGELPMNIGYGFSVSYNNKVLLIGGETDGGKALTSVKAISYDGKKL TIE Haemophilus influenzae NYSGXRC-6005b SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0148 GENBANK AAA97206 MTTLTVRVFTTAEIIYRKTVIALVCHLNCSRQETVTMNKTITALAIMMASFAANASVLPETPVPFKSGTGAIDNDT VYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTN SWVKLMSHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAIDKINAHYFDKKAEDYFFNKFLL SFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPVSSPDGVAGG FAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPWNNSLLI IGGETAGGKAVTDSVLITVKDNKVTVQN Escherichia coli NYSGXRC-6005c SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0148 GENBANK NP_460102.1 MGMQMKNFKKMMTLMALCFSVAITTSGYATTLPDIPEPLKNGTGAIDNNGVIYVGLGTAGTSWYKIDLKKQHKDWE RIKSFPGGAREQSVSVFLNDELYVFGGVGKKNSESPLQVYSDVYKYSPVKNTWQKVDTISPVGLTGHTGVKLNET MVLITGGVNEHIFDKYFIDIAAAAADESEKNKVIYNYFNKPAKDYFFNKIVFIYNAKENTWKNAGELPGAGTAGS SSVMGNNFLMLINGELKPGLRTDVIYRAMWDNDKLTWLKNSQLPPSPGEQQQEGLAGAFSGYSHGVLLVGGGANF PGAKQNYTNGKFYSHEGINKKWRDEVYGLINGHWQYMGKMKQPLGYGVSVSYGDEVFLIGGENAKGKPVSSVTSF TMRDGNLLIK Salmonella typhimurium NYSGXRC-6005d SGX Pharmaceuticals 2003-03-06 active Selected Cloned HI0148 MNMKTLLTYATLLSVTAFSHVVYADNQWPDLPTGFKDGVGAQVGSKVYVGLGSLGKSFYVLDLNALSKGWQKIADF TGAERSGATASVIGNYIYLFGGSGKAEPSDPSPILFDSVYRYDTKKDSWEKMNTTSPVGLLGASSYSPDNRQILF FGGYNKAYFDRYLRDISTTDKQVNPEVWQRIVDDYMGMTPTDYKWNRNVISYLPEKQEWRDLGVSTYLPNCGSAT VIEGNKVTLISGEIKPGLRTAEVKQYEFGMDQPWKSLLPLPAPQTSNIQEGVAGAFSGKTNGVVVVAGGANFHGA KQAFENGKMFAHEGLPKAFNSEIYVEKEGIWSTVNSLPEGLAYGASFTTSEGVLIVGGEKSGKEMSHKVYMLAWN GSTVEVID Vibrio cholerae NYSGXRC-6006a SGX Pharmaceuticals 2003-03-19 active Selected Cloned Expressed Soluble Purified HI0152 ICEDB: T884 GENBANK NP_438322.1 MTTYIAYGNINQPFSLESLPDELIPENLYQIETDSSRVFQRHQCRRLAHLLLFQLLKIAGKSTALLSQIHRTESGR PYFLDERIDFNISHSGDWVAVILDIRNEEKSAVGIDIEFPKIRNFTALMEHIAPKEEIDWFHHQQDSLNAFYRCW CLREAVLKSQGFGIVKLSNVRHFPEQQKIFSDYCPQGQLWFTDELPIYLAAFVNHQEKLPHFYEWNRESLQIKEL EKYVLYEVN Haemophilus influenzae NYSGXRC-6006b SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0152 GENBANK NP_290041 MYRIVLGKVSTLSAAPLPPGLREQAPQGPRRERWLAGRALLSHTLSPLPEIIYGEQGKPAFAPETPLWFNLSHSGD DIALLLSDEGEVGCDIEVIRPRANWRWLANAVFSLGEHAEMDAVHPDQQLEMFWRIWTRKEAIVKQRGGSAWQIV SVDSTYHSSLSVSHCQLENLSLAICTPTPFTLTADSVQWIDSVN Escherichia coli O157:H7 NYSGXRC-6006c SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0152 MMTITTDRTPPAAGAALDRNRSAYAGLADVLERAGLAEHALYLNWGYRPVDGQPDWAARELPPGELGRMQARLVLE VLGDTPLDGRRVLDVGCGRGGALALMGRLHAPAALAGADISAANIAYCRKRHTHPRLRFQIADACRLPYPDSSMD VVFNLESSGAYPDIGAFFHHVHRILRVGGRFCLADVFDADSVAWVRAALEQAGFTLERERSIPAQVRAARERASP GIWRRLDTALTALDAPGLRRELERYLAAPSSGLFQALEDGRVDYRLFHWRKTCPAAGRIDADVIARLATRSARLD AALQDRAPSAAAPQSPAPGPANASASAWFPFTAPDAQAGFNVFALPYAGGGASVYRAWTLPRRPGAAPWQLCPVQ LPGRESRFGEPLIDDMATLADRLADAIGPYAHRPWALLGCSLGCKIAFEVARRFARQGRPPALLFLMACPAPGLP LGRRISTRAEADFAREVCHLGGTPPEVLADAEMMRTLMPILRNDSALAEHYVAAEDATVNVPIVMVAAGDDHLVT VEEARRWQRHAGAGFDWRLVDGGHFFLRQRRRELTDWLLDALRRGERTLPVQTTTTDVPDVPCSTPEQPRDPSRM PAPGASANLVLAPGEILVVTAPRSLAARLTPAVLSDDEQRQLARFAFDADRERYLAAHWAKRRVLGALLAAAPRS LRFGAQAGGKPYLIGEALHFSLSHSGDRVAVAVCRHAPVGVDIEQARGIACHASAARIMHPLDRIAPQCETPEDR FLAAWSLKEAVAKCTGAGLALPFDSLRLAFAGNGRYGCLLGTHAAWEAHHQHEDGVHLAVASATPWAALRILPLD AALAEG Ralstonia solanacearum NYSGXRC-6006d SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0152 GENBANK NP_462484.1 MYQVVLGKVSTLSAGQLPDALIAQAPQGVRRASWLAGRVLLSRALSPLPEMVYGEQGKPAFSAGAPLWFNLSHSGD TIALLLSDEGEVGCDIEVIRPRDNWRSLANAVFSLGEHAEMEAERPEQQLAAFWRIWTRKEAIVKQRGGSAWQIV SVDSTLPSALSVSQCQLDTLSLAVCTPTPFTLTPQTITKAL Salmonella typhimurium NYSGXRC-6006e SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0152 VCERHWQWGNVRLWLRGRARGERGEPQARLVFSKALGWDPEALPLGRDVRGRPRFAGSLSFWDISWSHSGDYLLLG LGHGGCLGVDLERERFRPHLLDLAQRFFHPNETAVLRTLDEPARQALFFRLWCAKEAILKAHGAGIAFGLHRLHL AEDEGHLMLVECDAALGTAMAWRIDEWQAAPGYRAALAWRPFATIE Xylella fastidiosa NYSGXRC-6007a SGX Pharmaceuticals 2003-03-19 active Selected Cloned Expressed Soluble Purified HI0175 ICEDB: T893 GENBANK NP_438343.1 MQAINPNWNVPKNIHAFTTTREGGVSLAPYLSFNLGDHVGDNKSAVKTNRTLLVEKFGLPQTPIFLTQTHSTRVIQ LPYSGQNLEADAVYTNVPNQVCVVMTADCLPVLFTTTSGNEVAATHAGWRGLCDGVLEETVKYFQAKPEDIIAWF GPAIGPKAFQVGIDVVEKFVVVDEKAKLAFQPDAIEEGKYLSNLYQIATQRLNNLGITQIYGGNHCTFNEKEKFF SYRRDNQTGRMASVIWFE Haemophilus influenzae NYSGXRC-6007b SGX Pharmaceuticals 2003-03-06 active Selected Cloned HI0175 GENBANK NP_253233.1 MNAWLTPDWPAPARVRACVTTRSGGVSQAPFDSLNLGAHVDDDPRAVEENRRRLTERLECRPSWLDQVHGVTVVEA DPSRVLRADASWSAMPGVACTIMTADCLPALFCDRSGTRVAAAHAGWRGLAAGVLEATVDSLGVPGDELLVWLGP AIGPRAFEVGGEVRDAFVAAHAEARSAFVPSANPGRFMADIYRLARIRLGAHGVTAVHGGGFCTFSDTARFYSYR RSSRTGRFASLVWLQD Pseudomonas aeruginosa NYSGXRC-6007c SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0175 GENBANK NP_389420.1 MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQKPFESLNTGLHVHDKDADVVKNREYIADMFNTD LQSWVFADQTHDNRVQKVTQRDRGKGAREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAG WKGTVKQIGREMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKAQYQLDLKE LNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMKEA Bacillus subtilis NYSGXRC-6007d SGX Pharmaceuticals 2003-03-06 active Selected Cloned Expressed HI0175 GENBANK NP_216665 LLASTRHIARGDTGNVSVRIRRVTTTRAGGVSAPPFDTFNLGDHVGDDPAAVAANRARLAAAIGLPGNRVVWMNQV HGDRVELVDQPRNTALDDTDGLVTATPRLALAVVTADCVPVLMADARAGIAAAVHAGRAGAQRGVVVRALEVMLS LGAQVRDISALLGPAVSGRNYEVPAAMADEVEAALPGSRTTTAAGTPGVDLRAGIACQLRDLGVESIDVDPRCTV ADPTLFSHRRDAPTGRFASLVWME Mycobacterium tuberculosis NYSGXRC-6007e SGX Pharmaceuticals 2003-03-19 active Selected Cloned Expressed Soluble Purified HI0175 ICEDB: T900 GENBANK YP_186063.1 VNDNFKKQPHHLIYEELLQQGITLGITTRGDGLSDYPKNAFNMARYIDDRPYNITQHQLQLAEEIAFDRKNWVFPI QTHENKVACITKDDIGTNIDTLTDALHGIDAMYTYDSNVLLTMCYADCVPVYFYSTKHHFIALAHAGWRGTYTEI VKEVLKHVNFDLKDLHVVIGPSTSSSYEINDDIKNKFETLPIDSANYIETRGRDRHGIDLKKANAELLNYYGVPK ENIYTTAYATSEHLELFFSYRLEKGQTGRMLAFIGQQ Staphylococcus aureus NYSGXRC-6007j SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0175 MGRFPSWVLVADWPAPPGVMVLSTLRGGPGVSVAPFDRLNLGNCSGVAGDAPVCVERNRSRLVEMLGLPSVPHWLR QVHGVEVLRVDALLQSIARVVEPTADAAVTSVVGAVLAILTADCLPVVLAAVDGSEIGVVHAGWRGLADDVLGRT VAALRTSPEYLQAWLGPAAGPQAYEVGVDVYAAFVERDSGAACAFSVTRPGHWYVDLYALARQRLMRAGLSAVSI YGGGLCTISDPQRFFSHRRDRRSGRFATLAWIGC Xylella fastidiosa NYSGXRC-6007k SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0175 MSISSDWIVPDWPAPPSVRALSTTRQGGVSTGPYGLAGGLPGGLNLGRHVGDGPDAVTQNRRLLRAVLPAEPAWME QVHGTVVADLDQPLPAPVVADAAIAASPGRVCVVMTADCLPVLLCDARGVTVGAAHAGWRGLCSGVIEQTVERMT DALRACGQEADPTWLAWLGPAIGPDCFEVGAEVRQAFIDAARPDELPATRAAFAEGAADGKFLADLYALARLRLA RAGCRDVHGGGLCTMTDAERFYSYRRDRTTGRMATLIWRAA Ralstonia solanacearum NYSGXRC-6007l SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0175 MNHTSGITPLHPSIFHNILGLVALQTTRVGGVSASPLDSLNLGTHVGDDPERVRENERRLCAFLEISCESIVTTGQ VHGTEIAVVTGPGKLDGYDALITTVRGLFVGILTADCYPILIYDRRTRACGAAHAGWQGTAGRIAEKTVNAMHNS FGTRPEDCLAWVGTGISGECYEIGGEVAARFSSRYLKPSPSGEGRQLLDLSAANRDQLIEAGIPPSQVQCSELCS YRDADRFFSYRRDNGKTGRMLALIGLRHSD Chlorobium tepidum NYSGXRC-6007m SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0175 MQNATLPLPLQSPLLAASGENRVRHGFFTRQGGVSEGLYQGLNVGLGSHDEPEKVQENRRRVTQWFGLSADRLATV HQVHSPDVVVVDDNYDGNRPQADAMVTATPGFVLGVLSADCGPILFADAQAGVVGAAHAGWKGALFGVLENTIEA MVKLGASRERIAASLGPSISQDNYEVGPEYVARFTDIDPAYADYFAATERQGHALFDLKQFTIDRLTKAGVKAEN LGLCTYPDEHRFYSYRRTTHRAEPDYGRQISAIAILED Agrobacterium tumefaciens NYSGXRC-6007o SGX Pharmaceuticals 2003-01-30 active Selected HI0175 MTAPGLPLLRAPNLAVPHAFTTRAGGVSAGPYAGLNLDDRSDDPRPVAENRARLAAALGFAADDFARLNQVHGVQV VHAQAPGFWEGDALVTATPGVLLAIGTADCYPLLLADPEAGVIGAAHAGWKGTVGRIGQRTVEQMVNLGARPERI HAAVGPGICGEQYEVGEDVAAQFRAAGLGEWVLEREGRTHLDLAGANRALLEGAGVGDLWVSGRCSTEADFYSYR RDAGQTGRMWAVIGLPRREGQTGEARA Deinococcus radiodurans NYSGXRC-6008a SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MTQYKTIAESNNFIVLDQYNKFVEESNAGYQTERSLEREFIRDLQAQGYEYLQWLNNHDELIKNLRAQLQRLNNVV FSDAEWQRFLEEYLDKPSDNLIEKTRKIHDDYIYDFVFDNGRIQNIYLLDKKNLANNSLQVINQFKQTGSYDNRY DVTILVNGLPLYELKKRGVAIREAFNQIHRYSKESFNKENSLFKYIQIFVISNGTDTRYFANTTKRNKNSYDFTM NWATAKNTLIKDLKDFTATFLQKNTLLNVLVNYCVFDVSDTLLIMRPYQIAATERILWKIQISYLAKNWSNRESG GYIWHTTGSGKTLTSFKASRLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSESTAGLKRNIEKDDNK IIVTTIQKLNNLMKSEENLSIYQKQVVFIFDEAHRSQFGEAQKNLKRKFKKFYQFGFTGTPIFPENALGAETTAS VFGAELHSYVITDAIRDDKVLKFKVDYNDVRPQFKALETEKDPEKLTALEQKQAFLHPERIKEISQYLLNNFKQK THRLNATGKGFNAMFAVSSVEAAKRYYETLQNLQAEQEYPLKIATIFSFAANEEQDAIGDIPDETFEPTALNSTA KEFLTKAIDDYNHYFGTNYGVDSQSFQNYYRDLAKRVKNQEVDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLM QAFSRTNRIYDTTKTFGNIVTFRDLEQNTIDAITLFGDKNTKNVVLEKSYDSYFNGDDNQRGYAEIVKELKESFP DPTEIETEQDKKEFVKLFGEYLRVENILQNYDEFAALQALQAVDLNDPIAMEKFKQVHYVNDEQIAEMLKVPTLP VRAEQDYRSTYNDIRDWLRQRKEGNDKDNSPINWDDVVFEVDLLKSQEINLDYILALIFEHHKKNQDKEVLIDEI RRTVRSSLGNRAKESLIVDFINQTNLDDIPDKATLIDSFFLFAQAEQRKEAESLIQEENLNVDAAKRYISTSLKR EYASENGTALNEVLPKMSLLKPQYLTKKQKIFQKIAAFVEKFKGVGGKI Haemophilus influenzae NYSGXRC-6008b SGX Pharmaceuticals 2003-01-30 active Selected HI0218 LQVIHQYSNKGGKYQNRYDVSILVNGLPLVHVELKKRGVAIREAFNQIKRYKRDSFSAEDGLFDFVQIFVISNGTS SKYYSNTTRIAQLEKNHKADTFEFTNYWADSKNHNIEDLMDFAKAFFAKRSLLNVLTCYCVFTSEEVLLVMRPYQ IVAAERILEKIKTAQNSKTKNQSKGYIWHTTGSGKTLTSFKSATLAKELESVSKVLFVVDRKDLDYQTMKEYDKF QKDCANSNTSTKILKEQLEDSNAKIIITTIQKLDKFVKSHKGHAIFNEEVVMIFDECHRSQLGSMHQAITKAFKK YHLFGFTGTPIFAANCDKNNPLGTTEQKFGKCLHQYTIIDAIRDKNVLPFRVEYHNTIKAKEDIKDNKVRAVDEK NALLDTRRIKEITKCILERFNQATKNKKFNSILACSSIEALKKYYQAFKEEKHDLKIAAIFSYSANEEIDTLEDE NNESACRLDKSSRDFLEGAIADYNGMFGVSFDTSDQKFQSYYKDLSQKMKERKIDLLMVVNMFLTGFDATRLNTL WVDKNLKYHGLIQAFSRANRILDSVKTHGNIVCFRDLEQDLNDALMLFGNKDAQSIALLRKYEDYLKGYTDNNKE YEGYEGLIKRLLTEFPLKEPIVSESQKKDFIKLFGKILKLENILNSFENFKKDDYINPRDFQDYQSKYLDFYDAM RSEKGKDKEEINDDLIFEIELIKQVEVNIDYILNLIEEFAKEHGVEIQGVKTKIEPIINSSIELRNKKDLIMDFI DKYNKDQEVHAHFQDYIHQKREEEFQNIIEENRLNEEKAYSFMQHAFKGGEISFSGTEFPKIIEEKPSMFGKNSR YQEVKEKVAASLSRFFHRFCDLTSAIFKKNEVKKDEVNEK Helicobacter pylori NYSGXRC-6008c SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MAYQSEYALENEMMNQLEQLGYERVTIRDNKQLLDNFRTILNERHADKLEGNPLTDKEFQRLLTMIDGKSIFESAR ILRDKLPLRRDDESEIYLSFLDKKSWCKNKFQVTNQVSVEDTYKARYDVTILINGLPLVQVELKRRGIDINEAFN QVKRYRKQNYTGLFRYIQMFIISNGVETRYFSNNDSELLKSHMFYWSDKQNNRINTLQSFAESFMRPCQLAKMIS RYMIINETDRILMAMRPYQVYAVEALIQQATETGNNGYVWHTTGSGKTLTSFKASQILSQQDDIKKVIFLVDRKD LDSQTEEEFNKFAKGAVDKTFNTSQLVRQLNDKSLPLIVTTIQKMAKAIQGNAHLLEQYKTNKVVFIIDECHRSQ FGDMHRLVKQHFKNAQYFGFTGTPRFPENSSQDGRTTADIFGRCLHTYLIRDAIHDGNVLGFSVDYINTFKNKAL KAEDNSMVEAIDTEEVWLADKRVELVTRHIINNHDKYTRNRQYSSIFTVQSIHALIKYYETFKRLNKKLEQPLTI AGIFTFKPNEDDRDGEVPYHSREKLEIMISDYNKKFETNFSTDTTNEYFNHISKNVKKGVKDSKIDILIVVNMFL TGFDSKVLNTLYVDKNLMYHDLIQAYSRTNRVEKESKPFGKIVNYRDLKKETDDALRVFSQTNDTDTILMRSYEE YKKEFMDAYRELKMIVPTPHMVDDIQDEEELKRFVEAYRLLAKIILRLKAFDEFEFTIDEIGMDEQENEDYKSKY LAVYDQVKRATAEKNKVSILNDIDFEIEMMRNDTINVNYIMNILRQIDLEDKAEQRRNQEQIRRILDHADDPTLR LKRDLIREFIDNVVPSLNKDDDIDQEYVNFESIKKEAEFKGFAGERSIDEQALKTISNDYQYSGVVNPHHLKKMI GDLPLKEKRKARKAIESFVAETTEKYGV Staphylococcus aureus NYSGXRC-6008d SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MRIRRRLKNIYLLDKKNLARNHVQVINQFEQTGTHANRYDVTVLVNGLPLVQIELKKRGVAVREAFNQVHRYSKES FNSENSLFKFLQIFVISNGTDTRYFANTTKRDKNSFDFTMNWARSDNHPIKDLKDFTATFLQKSVLLGVLLHYSV FDANDTLLIMRPYQIAAAERILWKINSSAQAKNWSKPESGGYVWHTTGSGKTLTSFKAARLATESAFIDKVFFVV DRKDLDYQTMKEYQRFSPDSVNGSESTAGLKRNLEKDDNKIIVTTIQKLNNLMKGEDNLPVYHQRVVFIFDECHR SQFGEAQKNLKKKFKKFCQFGFTGTPIFPENALGAETTAGVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFK AVEAEQDEKKLSAAENHKALLHPERIREITQYILNQFRQKTHRLNAGGKGFNAMFAVSSVDAAKCYYEAFKTQQA GSLHPLKVATIFSFAANEEQNAVGEIVDETFEPEAMDSSAKEFLQAAINDYNACFKTNFGTDSKAFQNYYRDLAK RVKNQEIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVCFRDLEQATIDAITL FGDKNTKNVVLEKSYEEYMNGYTDSQTGEARRGYLDVAKELRERFPDPDKIETEKDKKDFAKLFGEYLRAENVLQ NYDEFAALRELQSVDAADEDAMKAFQEKYYLSDEDVQEMRQVPMPSERAVQDYRSAYNDIRDWLRRQKAGEQKEQ SKIDWDDVVFEVDLLKSQEINLDYILQLVFEHHKKIKGKAELVEEIRRIIRASIGHRAKEGLIVDFINDTDLDKV PDVPAILETFYTYAQEVMRHEAAGLIAAEGLNETAAKRYLISSLKRGYASENGTELTETLPKMSPLNPQYLTKKQ SVFQKIAAFVEKFAGIGTDI Neisseria meningitidis NYSGXRC-6008e SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MKSVDYSKVVLPVAELTNGIILEEFVKTERYNRDVYQTENEMEKKLIEDLVQGQHYELLTIHTAEELMINLREQIE KLNNVTFTNDEWQRFLDEYLDRPNDGMIEKTRKIQENHIYDFIFDDGHIKNIILIDKKNIHQNHLQVVSQIRQKG SHSNRYDVTILVNGLPLVQIELKKRGIPMKEAFEQIHRYSKESFNTQHSLFQYIQIFVISNGTRTRYFANTTAQN KNHFEFTCEWADKKNKIIYDLEDFAQTFLNKQVLLSVLTKYCVFDTSDTLLIMRPYQIAATEAIMRQIHVAHENK LYGTTEAGGFIWHTTGSGKTLTSFKAARLATELDYIDKVFFVVDRKDLDYQTMKEYQKFQKDSVNGSKNTKELKR AIEKNDSKIVVTTIQKLNEFVKKNPEHPIFEKQCVLIYDECHRSQFGDTQRKVRSSFRAHYQFGFTGTPIFEDNT LTGMLTSTIFGKQLHSYIITDAIRDNKVLKFKVDYNYIKPELNKFREAEVTSGQENDKKKLKKIEKELLLHPERI STISEYLLKVFDDKTHRNVHYTHKQKQLKGFNAMFAVQNVKAAKAYYEEINKQQRQLPVDKRIKIATIYSYVPNE EQLAYGAIDSENFEPTKMDLSSKEFLDLAISDYNKHFKTNFSTEGKDFQNYYKDLTKRVKSKEVDLLIVVGMFLT GFDAPTLNTLFVDKNLRYHGLIQAFSRTNRILNKEKPFGNIVCFRDLEKATNDALTLYGESHSISVVLEKSYEEY MSGFTDKETGITVKGYQEVCQEILEKFPDPTEITLESEKREFVKLFGEVLKLENVLRNYDEFTPEEHLITPGQMQ DMRSVYVDIREEAYGNGRTGKNEETGIDLSDIEFEIELLKTDEINLDYIISLISAKAQDNDSKETLKRDISRVIR SSIDMRAKEELVIGFINETHLEQLKDNQTILEAFYAYGNQKKKKAIEDLAEELTLKGDYRRFINRSIAQGYVSSS GTDINNLMPATSRRKGARERKKHEILVKLQKLVETYTGI Streptococcus mutans NYSGXRC-6008f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0218 MSEPIPPFRYAPIVCSEQSTIVAEFVPEASGVREAGYQSEAELEAAFITQLQGQAYEYLSITSEAALLANLRRQLE KLNKVTLSDAEWEGFFSTCIAGAHDGIVQKTARIQEDHVQVLKRDDGTIKNMCLLDKGNIHNNILQVMNQYAVEG ARGNRYDVTVLVNGLPMVHVELKRRGVDIREAFNQINRYQRDSFWAGSGLFDYVQLFVISNGTLTKYYSNTVRAG HVEEQSNKRSKSKTSNSFSFAIWWADAKNQPITELTSFTKTFFAKHSLLNVLTKYCVFNANRKLLVMRPYQIVAA ERILQRIVTATHQQQLGTVAAGGYIWHTTGSGKTLTSFKVAQLACGLGVIDKVLFVVDRKDLDYQTMREYESFEK GAANSNTSTAVLQRQLEDSDVRIIITTIQKLSRFVAKHKQHPVYGAHVAVIFDECHRSQFGDMHTEITRAFQRYH LFGFTGTPIFAENAGSTQNPMRRTTQQTFGDTLHTYTIVDAINDKTVLPFRIDYINTIKSQPNINDKQVAAIDTE RALLAPERIRQIVSYIREHFDQKTKRASIYRHEGQRLQGFNALLATASIDAAKRYYAELMAQQKDLPEAQRLKVG LIYSVAANEGDGDELLAEEEFETERLDQDARNFLEAAIQDYNALFGTSFDTSADKFQNYYKDVSERLKKRKLDIL IVVNMFLTGFDATTLNTLWVDKRLKAHGLIQAYSRTNRILNSVKSYGNIVSFRNLEQETNEALALFGNKDAKGIV LLRPYAEYYKEYEERVGELVAAFPLGKVIVGEAAQKAFITLFGSILRLKNILTAFDDFAGQEVLTEREFQDYQSL YLNLYAEFRSASAAEKESINDDVVFEIELIKQVEINVDFILLLVEQYVKKKGTGEDKDIRATIERAIHSSPSLRN KKELIEQFVDAVSMKATVDAQWQAFVAVKQSQELEGIIAEENLNAEATREFIANAFRDGSIPATGTAITKILPPV SRFSKNNGHAAKKQTVLDKLATFFERYFGLV Xylella fastidiosa NYSGXRC-6008g SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MENKVLLAEHENSTVVAEFKSIKVHSNKFESEAELEETFIKLLIAQGYEYLPIKNNNDLKNNLRKQIEKLNNYQFT NNEESFLSTYLLNPNDGIEARSKKIHEDYSYPLKKDKDSITKNIKIIDKNNIHNNSIQVINQYQNNNLDNQQKTR YDVSILINGLPLVHIELKRRGTNLKEAFNQIKRYANHSFTDLYLYTQIYVISNGTQTKYYSNTTRETSIKERNNT NSKKTSNSFEFTSYADSKNNQILDLIDFCQTFFAKHTILNILTKYCVFTSDNTLMVLRPYQIVATERIINRIKIS LNDKKLLGTTGAGGYIHTTGSGKTLTSFKTAALAKEIEGVDKVLFVVDRKDLDYQTTKEYEKYSKGCVSANTNVN ELAKQIGNQENKIIITTIQKLGIFISKNPKHPIYSKNVVLVFDECHRSQFGDLHKKITKKSFKKYMIFGFTGTPI LEENSNVKNKNIFFTTEHLFGACLHKYTIDKAIRDGNVLGFRTEYYKTLSEKDDIDDETSSTGIDKKEALENPIR ISEIVDFILKNYNRLTKRNEEFFEHNKIANINEVITSRNKLSENKVLTTLNGFNSILACSSINAAKIYYSEFKKQ QQKFPQEEKLKIGLIYSYLPSEQESNDNELSNFELLDENNENTNQLDLDSRNFLDEAIKDYNEMFGTSYSTDNAN FNNYYKDFSLRLKDRSLDIAIVVNMFLTGFDATTLNTLLDKKLKYHSLIQAMSRTNRILNGVKSNGNIVFFINLE DEVNEALRLFSSESNINSSIAILRSFKEYYEGYYNEDNQYIQGYRNLVEELKSNFKIPFNGTKEEERIFIKLFGD ILKYKNLLSQFSEFEQNDDLIGTEMQDYQSIYIGLRDKYQDKKRMETDSIVSDLDFKIELISQQDIGVDYILKLM NEKLKKDLKEVKYHDLERDILSSLKARKKKDLIIEFVNEINKLPNKDEIDIFNEWSKFIKNKKESELIKIINENK LDNKKTFEFMKKAFENNEFNENGVDIVNLMPPTSFFKKSNQNSNRSKIKENATEKLLEYFEKFRG Ureaplasma urealyticum NYSGXRC-6008h SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MGNQTKTELELEKELIHLLETGESQWTYRKELKTEDALWDNFFKILAQNNTQYLNEEPLTASEKEQIKNQLNFVNY YEAAKWLAGENGIAKVQVQREDAKLGTIRLEVVKADNVAGGTSVYEIANQVAFSGSRDRRGDVTLLINGLPMIQI ELKSQNHQCIEAFNQVKKYDKEGQFRGIFSTLQMFVVSNKTDTRYIAAAKENKLNPNFLTQWVDQNNKPQKDLFA FAKEVLSIPRAHQMVMTYSVIDDDKKALILLRPYQIHAIEAVAEASRHRKSGYIWHTTGSGKTLTSYKVARNILQ IPAVEKSIFVIDRKDLDNQTASAFQSYAQNDIFDVDETEDTRQLIKNLESSDRRVVVTTIQKLNAMISQMESYDT PKFKKLKERLAHLNVVFVVDECHRAVTPERQRYLTNTFRNSRWYGFTGTPIFVENKRAQLGDLAQTTEQQYGKCL HQYTVKEAIHDKAVLGFQVEYKTTIPDMPEDSIPEEAYDHEEHMLAVLDSIINQSRKKLGFNNGIGQTFEGLLTV KSIARAQAYYDLMKKVKAGETDLVISKKVKEKLPDFPKVAITYSITENDNASISRQDKMTKNLEDYNHLFGTNFT IDNLQGYNRDLNDRLARKKDKFKDRHEQLDLVIVVDRLLTGFDAPCLSTIFIDRQPMKPQHIIQAFSRTNRIFES RKHYGQVVTFQTPLRFKEAVDKALSLYSNGGENDVLAPSWEEEKARFFEKVTVLKNIVPDPDAFPTIESAQTAFL KQYAKAFQAFDKLFASVQVYSDFNETLLSEVGLSDEVIDTYKGTYQNVIAEIRKRREDDEAIPEINIDYELESVQ MDDINYHYILTLIQAFVDQEQEALQERLNDNPMDQYIQDLAKSNPAMADSLAELWQDIQKEPKAYEGKSIVYELD NLIGDKIQRAIKHFADQWKADPDKLAFVATNYHSANSTKQVGMSTLKESLDYQAYKEKQGDSAMNKLKYKSQFER ELVQFIRDQIQPLKGH Streptococcus pyogenes NYSGXRC-6008i SGX Pharmaceuticals 2003-01-30 active Selected HI0218 VLFVVDRADLDYQTSKEFNYFSPECVDTTDNTGQLVTQMAGDSRLIVTTIQKLNRAIKSPRHEAAMSGLKDQPIVF IFDECHRSQFGETHKNILKFFTQAQMFGFTGTPIFADNATSNQHGKRTTRDLFQECLHKYVITNAIADENVLKFS VEYWGGMKRKDGTLITEPKSDRFETPERISGIVDWIIANHHRKTHGKKFSAMLCVSNVDTLITYYEIFKNQQQQG LHNLRIITIFTPSDNEEDEDANGLIGEPDFNISNDTSSRSHSRDKLNEFIADYNQMYKTQHSAKDGQAFYAYYKD ISKRMKDRDRENFQDAERADILLVVNMFITGFDVKKLNTLYVDKNLKYHGLIQAYSRTNRILGELKSQGNIVCFR NLKENTDQAVSLFSDPNANEQIFIEPYEYYIEKFNQGVEELRAIATIPNDVNKLISEDDQVNFVKAFRNLIRLQD VSKSFTEFSFSDLNLDEQTFEDYKSKYLDIYDKTRSKPDDEKESLVEEVDFELELIHRDEINVTYILKLLANLQR DIKDDATQEDYQNQKASILELIGKEAQLRSKRDLLEKFIEQRLPTLEPQEKLETVFQDFWTQERIEAIEQLCLEE NLQVTTVNQMIADYKFSGKEPLRETMLSACNEKPKLLERKKIFGRVVAKLLDIINKFDDALGELGEEE Nostoc sp. NYSGXRC-6008j SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MRSDSENNKIDYIEDFATHFLNKNALLNVICKFCVFRSNSDLVMRPYQICATERILEKIKEDNRNSKNSKNASKGG CIHSTGSGKTLTSFKAVQLASEIDFVDKVLFVVDRKDLDNQTIEEYEKFQAGSVSETENTNDLKEKILDDSTATR AIVTTIHKLKRLIDQRSKLKDEDLKKKNIVLIFDECHRSQFGKMKQEIDEFF Mycoplasma pneumoniae NYSGXRC-6008k SGX Pharmaceuticals 2003-01-30 active Selected HI0218 MLVNIEPREYQINVYKNSIDKNTLIVMPTGLGKTLIAAMLIEKFFKENKKSIFLAPTKPLVLQHMATLVKVLGLNN NEICAFTGEVDSQERELRWVTGKIFVSTPQVVLNDMKSGIIDITRFDLIVFDEAHRAVGNYAYVDIASEFLEYKK KLIIGLTASPGGEKGRFQEIVKNLGIENVVVKTEKDEDVRKYIKSIEMHLIKLKEPDQCGAIKDLLKSALDSVLK PLKDQGIKVGRTRKDMAESIQNLINRAKEDRSLFPLVRHLTAAIRIDYIIEYIETQGLDVAYQYVKDMEESQDQS IKRAYSMMKSLDDFRKAIENMKNVLPGYRNPKMMKVLEICQEKVIAGERAIVFTHFRATSDMLLAYLKNSSDKIK PVRFIGQADRGTDVGLSQEEQRQIIEQFRNGTYNVLIATSIAEEGLDIPDTDVVVFYEAVPSEIRFIQRKGRTGR SRSGEVYILVYENSRDMAYYYRSLKKVSMMNRNIMEYRDEHPYTKNERQENSNNGQRTIFDF Thermoplasma volcanium NYSGXRC-6008l SGX Pharmaceuticals 2003-01-30 active Selected HI0218 VEYVTHPLIKENTIERRMYQISIAATALTKNTLVVIPTGLGKTTIAALVIASRLLNEDGKVLFLAPTKPLVEQHAR FLKRVLKVEEIVSLSGEVPPEKRKELWEKARIVVSTPQVVENDLLAGRISLEDVILVVFDEAHRAVGNYAYVFIA KEYLRTAKKPLILAMTASPGSDPERIMEVIQNLGIEAIEVRTEWDSDVAPYVGKKRIEWIKVDIPEEMKEVKERL KECIKIRFKRLRELWIEVPENSSKRDLLALQEALQAEAASSQSSEIFEALSILAEIMKLQHAVELIETQGVKAVK SYLRKLVREATSKGGSKAAKSIVGDPIFKKAVIALSKCKVEHPKLEKLKEILKEQFEKNPDSRVIVFTNYRDSAE MLVNELSPLFPVAKFVGQASRDNDKGMRQKEQIETIDKFRRGVYKVLVATSVGEEGLDIPSTDLVVFYEAVPSEI RAIQRKGRTGRGREGRIVVLVTKGTRDEAYYYSSMKKERKMYDKILEIKRIIDRKQRSIGDYVLPEETGIKVIVD SRELRSEVVKHLREIGAKIEIRNLEVADYVVSDRVAVERKTVEDFLNSIIQKERLFSQVARLKSAYSRPVIIIEG ENFYRGGVHPNAVRGAIASLIIDFGIPVLRSSNARETAELIFAMARREQEERKRGVVEHTAKTKRTLKDEQEYIV SAISNVGNVIARNLLDYFQTIENIATADEEELAKVPKVGKKIAKRIRRVMTTPYSEAGFYDSESF Archaeoglobus fulgidus NYSGXRC-6009a SGX Pharmaceuticals 2003-01-30 active Selected HI0282 MINIIFLHGLLGTKNDWQKVIENLPHFNCIALDLPFHGQAKDLEVTNFEDSAEYLAQQIKSAVKNGPYFLVGYSLG GRIALYYALQAQLERSNLQGVILEGANLGLKTDEEKQARFQQDFAWAQRFMQESPEKVLNDWYQQPVFSHLTTEE RLQLVEKRKSNCGKNIGKMLLATSLSKQPDFSEKVRLSSLPFFYFCGERDHKFQVLAKENQIDLVTIPCAGHNSH LENSKYFSKKIENCILKIVRP Haemophilus influenzae NYSGXRC-6009b SGX Pharmaceuticals 2003-04-07 active Selected Cloned Expressed Soluble Purified HI0282 ICEDB: T914 GENBANK NP_416766 MILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRLYVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYN ILDFWLVGYSLGGRVAMMAACQGLAGLCGVIVEGGHPGLQNAEQRAERQRSDRQWVQRFLTEPLTAVFADWYQQP VFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAFYYLCGERDSKFRALAAELAADCHV IPRAGHNAHRENPAGVIASLAQILRF Escherichia coli NYSGXRC-6009c SGX Pharmaceuticals 2003-04-23 active Selected Cloned Expressed Soluble Purified HI0282 ICEDB: T919 GENBANK YP_185918.1 MTHYKYYEANVETNQVLVLLHGFLSDSRTYYNHIDKYTDICHVITIDLPGHGEDQSSMDETWNFDYITTLLDRILD KYKDKSITLFGYSMGGRVALYYAINGHIPISNLILESTSPGIKEEANQLERRLVDDARAKVLDIAGIELFVNDWE KLPLFQSQLELPVEIQHQIRLQRLSQSPQKMAKALRDYGTGQMPNLWPRLKEIKVPTLILAGEYDEKFVQIAKKM ANLIPNSKCKLISATGHTIHVEDSDEFDTMILGFLKEEQND Staphylococcus aureus NYSGXRC-6009d SGX Pharmaceuticals 2003-09-23 active Selected Cloned Expressed Soluble Purified HI0282 ICEDB: T913 GENBANK ZP_03983863.1 MERLIRGMQYHYQWLTPFDAKRTTVVCLHGFTGTLATFAAVFPSQTPYNVLGIDLPGHGATASLVAPERYTMKQVC HDIAELTESLNLPCFCLLGYSMGARTALGFALHYPQKVQHLLLESGSPGLATAAERQARICQDHRLAERLLEEPL VDFIDFWQELPLFQTQKALSVAQQMAIRQERLSQSAFGLVSSLWYMGTGAQESYWERLAELQPIPTDLLVGGEDQ KFIGIAKKMQARQPLLRLTIFPEAGHCIHLEQPTIFYEKVTALLEGAI Enterococcus faecalis NYSGXRC-6009e SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0282 MSNLPAIILVHGFWGGAAHWSKVILELKRLGHDNLHAVELPLTSLADDAERTRKMIAQQQGPVLLVGHSYGGAVIT EAGNQPNVVGLVYIAAFAPDSGESPGGITQEHLPLAAANLATDSDGYLWVKADRFHESFCQDLAADEGLVMGITQ KAPLASTFGDAIGSPAWKSKPSWYQISSADRMIAPENQERMAARIAPRKIVTLDASHASLASRAKEVAALIDEAA VATAH Pseudomonas aeruginosa NYSGXRC-6009g SGX Pharmaceuticals 2003-04-17 active Selected Cloned Expressed Soluble Purified HI0282 ICEDB: T918 GENBANK NP_461250.1 MMLHAQHMPGQPGTPSLVFLHGFSGDCHEWQPVGEQFHGCSRLYIDLPGHGGSAAIPVDGFADVIRLLRATLISYN ILKFWLVGYSLGGRVAMMAACQGIPGLCGLVVEGGHPGLQNEQARAERRLSDGRWAERFRHEPLTEVFHDWYQQP VFASLTAQQRQALTALRSQNNGETLAAMLEATSLAVQPDLREALNALAFPFYYLCGERDSKFRALAQEVAATCHV IRNAGHNAHRENPAGVVDSLAQILRL Salmonella typhimurium NYSGXRC-6009h SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0282 MLVNGQHYHLTAAISGEKPALLMLHGFTGTSETFQDSISGLKKRFNIIAPDLLGHGNTASPEEISSYTMENICEDL AGILHQLNVSRCFVLGYSMGGRVATAFAATFPKRVRGLILVSSSPGLEQEDIRASRVEADNRLADWIEEEGLVPF VDYWENLALFASQKVLSPEMKRRIRSERLSQNSHGLAMSLRGMGTGKQPSYWNCLANFTFPVLLITGALDEKFEK IAQEMHQLLPNSTHVSIQEAGHAVYLEQPNSFSSQLNYWLEDILKEEEK Listeria monocytogenes NYSGXRC-6010a SGX Pharmaceuticals 2003-04-23 active Selected Cloned Expressed Soluble Purified HI0329 ICEDB: T928 GENBANK NP_438493.1 VRILPQEPVIREEQNWLTILKNAISDPKLLLKALNLPEDDFEQSIAARKLFSLRVPQPFIDKIEKGNPQDPLFLQV MCSDLEFVQAEGFSTDPLEEKNANAVPNILHKYRNRLLFMAKGGCAVNCRYCFRRHFPYDENPGNKKSWQLALDY IAAHSEIEEVIFSGGDPLMAKDHELAWLIKHLENIPHLQRLRIHTRLPVVIPQRITDEFCTLLAETRLQTVMVTH INHPNEIDQIFAHAMQKLNAVNVTLLNQSVLLKGVNDDAQILKILSDKLFQTGILPYYLHLLDKVQGASHFLISD IEAMQIYKTLQSLTSGYLVPKLAREIAGEPNKTLYAE Haemophilus influenzae NYSGXRC-6010b SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0329 LKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLKKVINLTEDEEEGVRISTKTIPLNITPYYASLM DPDNPRCPVRMQSVPLSEEMHKTKYDLEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIG MGVPKKQLDAAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQRITDHLCE ILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGINDSVPIMKKLMHDLVKIRVRPYYIYQC DLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVPTFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPE PENYIPNQADAYFESVFPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLKE KKFLAQQKKQKETECGGDSS Bacillus subtilis NYSGXRC-6010c SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0329 VIRLKVKYYTSITQVEQLSPEERERLKRVEEKYRFRANSYYLSLIDWSDPDDPIRKIIVPEEDELEEWGTLDASNE KSYTVAKGLQHKYPDTALFLVNDVCGGFCRFCFRKRLFINVGAEVIRDITPQLDYIRTHKEITNVLLTGGDPLLL STEKLEKIVSSLREIDHVQIIRIGSKIPAFNPYRIIDDPDLLKMIRKYSTKEKKIYVMTQFNHPRELTREAIEAV NLLKDAGAVLCNQTPLLRGINDDPEVLGELLDRLSFVGVTPYYVFQNRPVSGNRKFAVPIEEGYEIFTKAISNIS GVAKRVRYVMSHRTGKIEIAALTKDFIVFKYHRAHDEKNRRKVMVYKRNPQALWFDDYSELLEEYTV Thermotoga maritima NYSGXRC-6010e SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0329 MVQLYQPKRHWKDISLWKDVTESQWNDWLWQLTHTIRTIDDLKQVINLTEEEEEGVRISTKTIPLNITPYYASLMN PDDPRCPIRMQSVPISKEIEKTKYDMEDPLAEDEDSPVAGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGM GVPKKQMDAAIDYIAQTPAVRDVLLSGGDGLLINDQILEYILKNLRAIPHVEIIRIGTRAPVVFPQRITDHLCSI LKKYHPVWLNTHFNTSLEITKEAKEACEKLVDAGVPVGNQAVILAGINDSTHIMKKLMHDLVAIRVRPYYVYQCD LSEGISHFRAPISKGIEIMEALRGHTSGYAVPTFVVDAPGGGGKVTLQPNYILSQSPSKTVLRNFEGVISTYPEP DHYVPGKADDYFAKMTGITGDERSIGIHRLMKDEEINLVPKGLKRLELRSVYEQDTRHRSLKDLREKRDQLKEKK WLAEQRKLQEGKKSDEM Bacillus halodurans NYSGXRC-6010f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0329 MAESRRKYYFPDVTDEQWNDWHWQVLNRIETLDQLKKYVTLTAEEEEGVKESLKVLRMAITPYYLSLIDPENPNCP IRKQAIPTHQELVRAPEDQVDPLSEDEDSPVPGLTHRYPDRVLFLITDKCSMYCRHCTRRRFAGQKDASSPSERI DRCIDYIANTPTVRDVLLSGGDALLVSDERLEYILKRLREIPHVEIVRIGSRTPVVLPQRITPQLVDMLKKYHPV WLNTHFNHPNEVTEEAVEACERMANAGIPLGNQTVLLRGINDCTHVMKRLVHLLVKMRVRPYYIYVCDLSLGIGH FRTPVSKGIEIIENLRGHTSGYAVPTFVVDAPGGGGKIPVMPNYVVSQSPRHVVLRNYEGVITTYTEPENYHEEC DCEDCRAGKHKEGVAALSGGQQLAIEPSDLARKKRKFDKN Porphyromonas gingivalis NYSGXRC-6010g SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0329 VPCARRCPMSETRLLHPQSTVRAQQMLPRGHRAAKWQGVPDEQWYDWKWQLKNRINSVEELQEVLTLTESEYRGAS AEGIFRLDITPYFASLMDPEDPTCPVRRQVIPTEEELQPFTSMMEDSLAEDKHSPVPGLVHRYPDRVLMLVTTQC ASYCRYCTRSRIVGDPTETFNPAEYEAQLNYLRNTPQVRDVLLSGGDPLTLAPKVLGRLLSELRKIEHIEIIRIG TRVPVFMPMRVTQELCDTLAEHHPLWMNIHVNHPKEITPEVAEACDRLTRAGVPLGNQSVLLRGVNDHPVIMQKL LRELVKIRVRPYYIYQCDLVHGAGHLRTTVSKGLEIMESLRGHTSGYSVPTYVVDAPGGGGKIPVAPNYVLSHSP EKLILRNFEGYIAAYSEPTDYTGPDMAIPDDWIRKEPGQTGIFGLMEGERISIEPREFSESRHRPGATQHRLNSR QDKWAAHGIGGSAPHAGDMTSGVSDTAPDGMVQAPQPVSGD Deinococcus radiodurans NYSGXRC-6010h SGX Pharmaceuticals 2003-03-10 active Selected Cloned Expressed HI0329 MAHIVTLNTPYREDWLTQLADVVTDPDELLRLLNIDADEKLLAGRSAKKLFALRVPRSFIDRMEKGNPDDPLLRQV LTSQDEFVVASGFSTDPLEEQHSVVPGLLHKYHNRALLLVKGGCAVNCRYCFRRHFPYAENQGNKRNWQTALEYV AAHPELDEMIFSGGDPLMAKEHELDWLLTQLEAIPHIKRLRIHSRLPIVIPARITEALVERFARSTLQILLVNHI NHANEVDETFRQAMAKLRRVGVTLLNQSVLLRGVNDNAQTLANLSNALFDAGVMPYYLHVLDKVQGAAHFMVSDD EARQIMRELLTLVSGYLVPKLAREIGGEPSKTPLDLQLRQQ Shigella flexneri NYSGXRC-6010i SGX Pharmaceuticals 2003-03-10 active Selected Cloned Expressed HI0329 MAHIVTLNTPLREDWLAQLADVVTNPDELLHLLQIEADENLRAGQDARRLFALRVPRAFIARMEKGNPDDPLLRQV LTSRDEFIVAPGFSTDPLEEQHSVVPGLLHKYQNRALLLVKGGCAVNCRYCFRRHFPYAENQGNKRNWTVALEYI AAHPELDEIIFSGGDPLMAKDHELDWLLTQLEAIKHVKRLRIHSRLPIVIPARITDELVARFDQSRLQILLVNHI NHANEVDEAFGLAMKKLRHVGVTLLNQSVLLRGVNDNARTLANLSNALFDAGVMPYYLHVLDKVQGAAHFMVTDD EARQIMRELLTLVSGYMVPRLAREIGGEPSKTPLDLQLRQC Salmonella typhimurium NYSGXRC-6010j SGX Pharmaceuticals 2003-03-10 active Selected Cloned Expressed HI0329 MPHIITRKVISVEQNWLQQLANAISDPLQLLQQLEIDPSPWQDGFEARKLFAQRVPQSFVDRMQKGNPADPLLRQV LPLSAEFEIHPGYSHDPLDEQNNTVPGLLHKYKNRCLLIVKGGCAINCRYCFRRHFPYEDNKGGKSAWQQSLDYI AQNPQLNEVIFSGGDPLMAKDHEIAWLMERIAAIPHIKRLRIHSRLPVVIPARITDELVELFAQTRLQVLLVTHI NHANEINLELKQQMARLRAVNVTLLNQGVLLKGVNDTVDAQVSLSETLFDAGILPYYLHVLDKVQGAAHFYVSDD KARQIMAGLIEQVSGYLVPKLTREIGGRPSKTPLDLHLE Vibrio cholerae NYSGXRC-6010k SGX Pharmaceuticals 2003-03-06 active Selected Cloned HI0329 VGARRGIWTMTRFETIKTPEALLEAGLIEAEALEGLRAVTQRYALAITPAVTGLMDSHDPQDPIARQFVPDLAELV HLPEERDDPIGDDAHSPVHGIVHRYPDRVLLKAVHVCPVYCRFCFRREMVGPQGNGMMSPEELDAAFAYIKENPA IWEVILTGGDPLVLSPRRLSDLMKRLRDIPHVKIVRFHTRVPVVDPDRIDAPLIEALKASGKTTYVALHANHARE LGDAARNACARLIDAGIAMVSQTVLLKGINDDPAVLADLMRSFVENRIKPYYLHHPDLAPGTSHFRLTIEEGQRI VSALRGHVSGLCQPTYVLDIPGGHGKAMIGRNAAEKTRDGCYSVSDFNGNDHIYPPATSGSY Agrobacterium tumefaciens NYSGXRC-6010l SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0329 MRQPTGHGGVFPQRSMITAASVPLQPSPASPLQPPRWQQVWREAIRDPRELLALLRLDPTSVGISEAAAAQFPLRV PRGFVARMRVGDLHDPLLRQVLPMDAEEDQIAGFGVDAVGDGAAKQATGIIQKYQGRILLIATGSCAVHCRYCFR RHFPYAEDTASHDRWREAAAFVRADPLIEEVILSGGDPLSLSTAKLVELTDALRSIPHLKRLRIHSRLPVVLPER IDTPLLEWLGALPWPVAFVIHANHANEFDASVDAALAALRGVGTQLLNQAVLLRGVNDNINALAALSERSFAAGV LPYYLHQLDRIAGTAHYEVEDARARALHAELVARLSGYLVPRFVREVPGDSSKRPL Xylella fastidiosa NYSGXRC-6010m SGX Pharmaceuticals 2003-01-30 active Selected HI0329 MSPVQTLRDARSLTEAGLVPSERLPALEAVAARYAVAITPAMAELIDPDRDDDPIARQFVPSPEELVSSPGEDGDP IGDAAHSPVEGIVHRYPDRVLLKPTHTCAVYCRFCFRREMVGPEGLSNLTPAQLDAAFAYIAQRPQIWEVIVTGG DPLVLSPRRLADLMDRLEAIDHVKIVRFHTRVPAVDPGAVTPELVAALKRSSKTVYVALHANHARELTPAARAAC AQIVDAGVPMVSQTVLLRGVNDNPETLVELMRAFVETRIRPYYLHHGDLAPGTAHLRTTVAEGQAIMRALRGTLS GLAQPTYVLDIPGGHGKVPVGPNYLSDGAVEDPDGAVRPYPPTA Caulobacter crescentus NYSGXRC-6010n SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0329 VSAASLSKSAPAEPQPGPPQPAAGPQALPAIGGLTPFSSVDWPGQLAAVVFIAGCPWRCHYCHNPHLQERARGLDW REVLDFLGRRRNLLDAVVFSGGEPLSEPRLPQLIDAARALGLRIGLHTGGIYPARFAEVLPRLDWVGLDIKTTAP RYDALTGRRGSAAPVDACLDLLLRSHCAFECRTTWHPDWLPEPQLLALAQSLCSRGVKHYAIQAYRSAPGTLATA LPSEATQHALAACFSSFSCR Ralstonia solanacearum NYSGXRC-6010o SGX Pharmaceuticals 2003-01-30 active Selected HI0329 MNYKVVEKFVSINGEGLKSGQLSVFIRFAGCNLNCNYCDTKWANEKDVKYTLMTEKEILSYIKETGVKNVTLTGGE PLLQDGIVELLNLLSLDSTLRVEIETNGSVSLENFLNFKNAPSFTMDYKLPDSSMENFMKTSNFKFLNKKDVIKF VVSSLKDLKKAMDIITEFNLSKKTNIYISPVFGRISPETIVDFMKDNKLNDVTLQIQIHKIIWNPNKRGV Clostridium acetobutylicum NYSGXRC-6011a SGX Pharmaceuticals 2003-01-30 active Selected HI0366 MKTISKQLSAVIFPFIFSACVSQSASSLNHQTAAKARVELALSYLQQNNPQLAKINLDKALQHDKNYYLVHSALAH YYQQQGQIENAFREYEIAVNLNHKQGDVHNNFGTFLCSQKKFEQAQQQFELALNSPNYYHQADTFENIVLCAYSA QKMDIYQQTLEKLRQIDGKRAEKFNSLK Haemophilus influenzae NYSGXRC-6011b SGX Pharmaceuticals 2003-01-30 active Selected HI0366 MTVRAALVFLLAVGLTGCVTSGDQNPLKTDKGRDEARDAYIQLGLGYLQRGNTEQAKVPLRKALEIDPSSADAHAA LAVVFQTEMEPKLADEEYRKALASDSRNARVLNNYGGFLYEQKRYEEAYQRLLEASQDTLYPERSRVFENLGLVS LQMKKPAQAKEYFEKSLRLNRNQPSVALEMADLLYKEREYVPARQYYDLFAQGGGQNARSLLLGIRLAKVFEDRD TAASYGLQLKRLYPGSLEYQEFQAEK Pseudomonas aeruginosa NYSGXRC-6011c SGX Pharmaceuticals 2003-01-30 active Selected HI0366 MKNVFGLGLIIALAGCVTVTETAGNATQSDPTEMAEARIALGLGYLENGSMIKARENLEKALQHAPDYYRSQLSMA HYYEAVGENDSARKMYRTALSEHPKNGNVLNNFGTFLCKQGEYDTADQYFRRAVEQPYYYLISASYENAGLCALK AGKTDNAREYFKRAIDHDPNRLLSILQLTKMEIEAGDYTPARLRLMDLNQRYGYQKASLKLLIELEKRAGNSALE QKYQTLLNSLS Vibrio cholerae NYSGXRC-6011d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0366 MSDKRETRIKSVQNLAPVYNVRDDAKTRRRVALTQMLGRAYNQFNAGDDAAAEKLLEEVLRQDRSSIDAWTLRATI YSKRGDVVHSGEYYRKAAQLAPQRGDVLNNYGAWLCANGYPAEALVWFERAMADPAYGEQPGTLANSGGCALQAG QRDRADHDLRRALELDPSNAYALESMARNEYDKHRYFEARAFSERRLATTVPATASVLKLAIQIEQELGDRAAAS RYQQRLVKEFPETVAVEPRG Xylella fastidiosa NYSGXRC-6011e SGX Pharmaceuticals 2003-01-30 active Selected HI0366 MDNSLAVVYLSVLVGILGFAVVSVFRQLFKTRKRESALSRLRNKLSKDKGTAQEYYELACIYSEKKVYTQAIPLFQ KALKAAEEEGEENTAPIYNGLGYAYFAQEQYDLAIRQYKEALKFKPDYVVALNNLGHAYERKKLTAQALQMYEEA LKFAPNNATAKRRAESLRRLVTA Nostoc sp. NYSGXRC-6011f SGX Pharmaceuticals 2003-01-30 active Selected HI0366 VESNSSYMEPNKIINKSIYYYNSKKYSQAIKLLEKEIFFYKNYYLYHYVLGMSYLRIGNLGNAQTYLKKAYTLNPS ESNIKQAIAILLVSQGKEEKAIQIWLKMIEENQEVDRSELSLEIIRKNPIKGSAFFKNSNLYEKLFPTIKAIPDK NSTKLIIIIIIGGIVFISMLAIYFIFYEQKTTTSANLKAEINKNLNNIAAYIDDIKINNKEKIKNEEGQFILILT SEEIKNSFEKIKIYLKKGKDNFARVEINKILNSNASESIKLKAKNLASFISRPDFISFNEHLNLKDIKKDPSIYS NVYVKWEGVVNNIEKKDNIIQFDFYVGYNKNVLSGIIPTKTTFDIDIDFKDNVEILGQIEYKKNKLTLNAITIRK IDKNEN Borrelia burgdorferi NYSGXRC-6012a SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MLENIRIVLIETSHSGNIGSAARAMKTMGLTQLCLVSPKSVDEQSYALSAGAENIVKNARVVDSFDEAVDDCPLVI GTSARLRHLQNTLIEPRECAEKVVAYKGKIAIVFGRERIGLTNEELLKCHYHLNIPANPDYSSLNLAMAVQLVSY ELRMAFLVQNNKKNSLSLIEKNYPTTDQLAYFFDYTERIYQSLGFIQNQGVMRKLKRLYYRAKLEKNELNILNGM LSAVEKRIDLTKEDN Haemophilus influenzae NYSGXRC-6012b SGX Pharmaceuticals 2003-01-30 active Selected HI0380 LLDRIRVVLVNTSHPGNIGGAARAMKNMGLSQLVLVQPESFPHGDAVARASGATDILDAARVVDTLEEALIGCSVV LGTSARDRRIPWPLLDPRECATTCLEHLEANGEVALVFGREYAGLTNEELQRCQFHVHIPSDPEFGSLNLAAAVQ VLTYEVRMAWLAAQGKPTKMEKFESTSMLNTELVTADELELYYAHLERTLIDIGFLDPEKPRHLMSRLRRLYGRS AISKLEMNILRGILTETQKVARGLSYKRSDD Pseudomonas aeruginosa NYSGXRC-6012c SGX Pharmaceuticals 2003-01-30 active Selected HI0380 VIIMISVILVNPKYSGNVGSIARVMMNFGFEELRIVGDKSIINNEAYMMAVHAREILDNAKFYNTFDEAIGDLDFV IATSGARGGDRNLKRVPITPKELADKILEVKGNIGIVFGREDDGLRNEEIDKCDLLVSIPTSEKYPIMNLSHAVA VILYEIYTKKVRNKFLDINMREASKEDKELLIRKFNEFIDKNEKIPEHKKELCKIIFKRLVNRAFISGKEAWTLM SAFK Methanococcus jannaschii NYSGXRC-6012d SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MMLERVKVVLVGTTHSGNIGSAARAMKVMGLSQMVLVDPQCQVDAQAIALAAGASEIALNAQIYPTLEAAVADCGL VVGTSARSRTLEWPMLEPRECGEKLISEANQHSVAMVFGRERTGLTNDELQLCHYHVCVPANPEYSSLNLAMAVQ LLSYEVRMAYLALQQSSQSSTLQEEYPRHQELERFYAHLEQVIMQTEFISAQQPGQVMNKLRRMFTRARPEAQEI NILRGILTSVQKSISRKE Vibrio cholerae NYSGXRC-6012e SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0380 LSRGEEEQSSASPVGQFTMQRYTSLVSLTMFAFPRLRFVLVGTQHPGNIGAAARAMKTMGISRLVLVAPECQLDEH AYRRSAGAEDVLEAASVHTVLADAVADCTFVLGCTARTRRVAFEELRPAAAASQILANINAAGEVALLFGRERTG LTNEELQLCHVAVHIPADPLFSSLNLAAAVQILAYEIRLASLDAPSAPLHSTSGFRKTPASHAQLEGLFGQFKQT LDEIDFHKGRAPESAMRKLRRLFAKAELTQQEIRLLRGVLSDVQRIVMLKRQRDT Xylella fastidiosa NYSGXRC-6012f SGX Pharmaceuticals 2003-03-31 active Selected Cloned HI0380 GENBANK NP_488582 MGLAGVRIVLVEPSGPLNVGAIARVMKNFGLAHLVLVSPQCDPLSEDAMRMAVHAKEILESAITVPTLPAALHGCV RAIATSGRDNDWGLTLETPRIALPWLLEETGQPSALIFGREDRGLSNEELIYAQRFIRIPTSPDYLSLNLASAVG ICCYELAQNLTPPETQTISETEFAPLEFVEAYYQQLESLLLRIGYLYPHTATSRMEKFRQLYNRAYLQTHEVGML RGILRQIEWAMDNQRDV Nostoc sp. NYSGXRC-6012g SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MPRFKHGQMTMAGTNSELELVAEGPAIILVEPQLGENIGMVARAMANFGLSELRLVNPRDGWPSEKARAAASKADH VIDGTRVFETLEEAIKDLNFVYATTARERYGFKPVRAPVTAADTLRTKFKAGEKTGILFGRERWGLTNEEVALAD EIVTFPVNPAFASLNIAQAVLLMSYEWMKSGMDDLGETLFQPIEQRPSTKEQVFGLFEHIEEALDARGYFHPAEK KPKMVDNLRAVLSRRGFSEQEISVFRGVIRSLDRFPRQWPKKTGRAAGPLAEGAGENAEDE Agrobacterium tumefaciens NYSGXRC-6012h SGX Pharmaceuticals 2003-01-30 active Selected HI0380 VILNEPQLAENIGSVARVMANFGLSDLRLVRPRDGWPQERAWASASGAHWPLDDAKVFDTLEAAIADLKLVYATTA RPRETRLPIYTPRESAGHLAEEVAQGRAVGLLFGGERAGLETDDIALCQAIVSIPIDERFRSLNLAQAVSINAYE WKMTQDDRPWRKFEQNVEEPADQAALLGLYGHLEDELEKAGFYHPPEKKPSMVRNLRAPLARARLSDQEVRTFRG VITALSKGRGRVLAKLAEKAKKEAP Caulobacter crescentus NYSGXRC-6012i SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0380 MNPASRASETSPARDNDVLRQRAARCRFVLVETSHPGNVGSTARALKTMGFCESGSYVLVRPREPGAQSHPDAVAM ASGADDVLADARVVDDVGEALAGASLVIALTARPREFGPRRIGPRAAAQEVAALLAAPGATVAFVFGNERYGLPN EVVERCHVVTHIPANPAYASLNLSQAVQLIAYEVRMALLADTGTGDTRVDGVGFVGEPATAEQIDGMFAHLERGL VEIGFLDPAQPKKLMPRLRRLFARTQLEAEEVNILRGIAKRMLGRRADAAAPPTGAADDCR Ralstonia solanacearum NYSGXRC-6012j SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MTTLKPALPAYLDNIRIILTRTSHPANIGSAARAMKTMGLHKLTIVAPNLMATPMTENPPVFDPEHPQSFKLPEES FILASGAADVLENATIAASLDEALADTTIACALTSRRREITAPLQTPRDLVSELLQTANRGEKVALVFGNETFGL SIEEVQACNRLMTINGNPDYFSLNLAQAVQVVCYEIFSQTGSPMTHLQQEDHAATHEQIKGMVAHMESVMNDIGF FNRRNGERLMRRMQSLFGRANTQTEDIDILRGFFNTVSHRIHKKD Neisseria meningitidis NYSGXRC-6012k SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MSSAAPSPTAQSLAVVLVSPKTPGNIGAAARAMLNMGASDLRIVAPRCDYLDSQAVAMAVHAGDLLRSAKIYPTLR EALADRDLSVGTSARIRADLPAPRHPAQVRGLVREAAAPALVFGPEETGLINSDLEQCQVTVRIPTGDYASLNLA QAVLLVCYEFLQGQDDVPEHSRQTATREDMEAMYGHLQDTMHLIGYTDAVRGRHTMRLWRAMLDRALMSSAESRM FRGLLRQVKWKVEQGSGKASTEIRIESEE Deinococcus radiodurans NYSGXRC-6012l SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MQKTDGLADRIWVVLVQPKYQGNIGAVARSMKNSGLSKLIIVGNRPDDEAFARSMGGRQILENAEIVDSLEEIVHR FTIVAGTSSTASSNLKRFRRLPVDPETFWKQMESQTGKVALVFGREDDGLRNEELDLCNYFIYIPGNPDYPVYNL SHAVAIVLYVMYRSYVPSDMIQHESIKPEHEVLLMSNILDIMKLSRYPAHKMRNAEVMLRRIIGRSMITEREYFK LMGIVRRIKEAIEGNLDEGNNERN Thermoplasma volcanium NYSGXRC-6012m SGX Pharmaceuticals 2003-01-30 active Selected HI0380 MIRVVLVEPEGEYNIGFVARLCKNFLVDELYIVNPRANISEAFRFSAGGREILEKAKIVNTFDKAINDVDIKIATS SIADNNGDILRKSIRPWEILPLIQGKKIALIFGRESVGLTREEIFKCDFLLYIPANPSYPVLNLSHAVGIVLYEI WKNRELLTNPQTSTISDQSIKLIDKYTEILYKLLKRSDDDYKMYIALKRAIIKGVKDEEEARVIVHFLRKLYTRI IHNEKEMNNVS Sulfolobus solfataricus NYSGXRC-6012o SGX Pharmaceuticals 2003-01-30 active Selected HI0380 LKSIRSRKSRRLRANRRKKRVHQPKLRQKPAKASQSRSRRMSRTDYISENVYIVLVYPKYQGNIGAVARSMWNSGL RHLIIIGNRPDDEAFARSMGGRFILENAEIYDDFASVISRFNVIAATSSTASSNEKHFRRLPLTPEKFWEEMSDQ GGKIALVFGREDDGLRNEEIEKCNYFINIPGNPEYPVYNLSHAVAIILYVMFTRFNPPENIEIRAIEPDHEDLML RNIIEVMRLTSYPEHKIRNTELLLRRLIARSRMSDREYFRMMGVIRRVKESLQRPLENESDHQRN Thermoplasma acidophilum NYSGXRC-6013a SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MDYENQIANIFSLNGELSQNIKGFRPRAEQLEMAYAVGKAIQNKSSLVIEAGTGTGKTFAYLAPALVFGKKTIIST GSKNLQDQLFNRDLPAIKKALNFTGKIALLKGRANYLCLERLDQVIAQGVLGDKSVLAELSKVRKWNNSTKTGDF TECIELAEDSPIIPQLTSTAESCLGTDCPNYSECYVASARKKALNADLVVVNHHLFFADMAVKESGFGELIPNAE VIIFDEAHQLPDIASQYFGQSLTSRQLFDLCKDINIVYRTELKDMQQLGTTSDTLLKVVQDFRLLLGNGSNVRGN WRELYTQSAVKKAFELLQEKIDFLSEVIKLALGRSQTLDSIFERVESIKIQLKRLSETNIVGYCYWYEGNGRQFG LHITPLTVADKFGAQLEAKEAAWIFTSATLEVGGTFNHFCQRLGIENATQKILYSPFNYPEQSLLCVPRYLPNTN QMNTLNSLGEILLPVIEANKGRCFVLCTSYSMMRGLAEYFREKSHLSILLQGETSKGKLLEQFIKETHSVLVATS SFWEGVDVRGDALSLVIIDKLPFTAPDEPLLKARIEDCRLQGGDPFNDIQIPEAVITLKQGVGRLIRDVTDRGVV IICDNRLVMRNYGETFLKSLPNSSRTRDLNKVIQFLQNK Haemophilus influenzae NYSGXRC-6013b SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MLSAELKSQIQGAYTRFLEAKELKPRYGQRLMIAEVAKALGVIKEDEEGHREGEPAVVAVEAGTGTGKTVAYSLAA IACAKASGKRLVIATATVALQEQIVHKDLPDLLRNSGLAFSFALAKGRGRYLCLSKLDVLLQEGQAQSATAQLFA DDGFNIDVDETSSKLFNQMIERLAGNRWDGDRDSWPEAIDDAHWAQLTTDHSQCTNRHCPNFQQCAFYKAREGMT KVDVIVTNHDLVLADLALGGGAILPDPRETLYVFDEGHHLPDKAIGHFAHFTRLRATADWLEQIAKNLTKLLAQH PLPGDLGRLIEQVPELAREIKTQQQFMFTACEEIGDFRAGEDMEGRERPRHRFVGGVVPEHIREMGIELKKGFSK LTDLFTRLTDILKEAMDGEGAGGIASHQAEEWYPLFGSLLARAQGNWELWTAFTCEDPQDSPPMARWLTLAESGS FYDIEANASPILAAETLRRNLWNVAYGVLVTSATLTALGTFDRYRMRAGLPRNAVTAVVPSPFHHAEAGVLRVPD LKADPRNAAEHTAAIIRELPELVKGARGSLVLFSSRKQMQEVFDGLDRDWRKRVFIQGNLSKQETLNKHKSRVDD GEDSVLFGLASFAEGVDLPGAYCEHVVIAKIPFAVPDDPVEAALAEWIEARGGNPFMEIAVPDASLRLVQACGRL LRTEQDRGTITLLDRRVVTQRYGKAILNALPPFRREIA Pseudomonas aeruginosa NYSGXRC-6013c SGX Pharmaceuticals 2003-01-30 active Selected HI0387 VSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHLVVQAGTGTGKSLAYLVPAIIRALCDDAPVVV STATIALQRQLVDRDLPQLVDSLTNALPRRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTAL GRDVQRLTAWASTTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTNHALL AIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDPKVTQRLQAASATFSSAIHDA RPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTASVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVW LEHEDNHESARAVLRVAPLSVAELLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHA KSGILYVAAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLCQGDDSTSTL VEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSARQRAVAARGGNGFMTVAASHAALLLA QGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRASLPPFWQTTNATQVRAALRRLARADAKAH Mycobacterium tuberculosis NYSGXRC-6013d SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKYINPNKSIPAFIEQLTGISNQMVENEQPFEAVA EEVFQLLDGAYFVAHNIHFDLGFVKYELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHR ADSDAEVTGLIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFSVREPEAID VRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFANREHALIEAPPGIGKTIGYLIPAALF AKKSKKPVIISTYSTLLQQQILTKDLPIVQDLFPFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLL VWLTETNTGDVAELNLPSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHKK RLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQRNSLPVDSFFELEEWLQH VQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKSWSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKG MKSKTVFLADEYQRSMKGLQHYCQTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNS VVLTSATLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQDTARYIELMAK EKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKLMKTFKTSNQAILLGTNHFWEGVDFPGDE LTTVMIVRLPFRSPDHPLHAAKCELARKKGKNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGY GRLFLDALPTTSVSEMTDSELEAYVAGEKE Bacillus subtilis NYSGXRC-6013e SGX Pharmaceuticals 2003-01-30 active Selected HI0387 VTDDFAADGQLAKAITGFKPREPQRQMAVAVTQAIENAQPLVVEAGTGTGKTYAYLAPALRAGKKVIISTGSKALQ DQLYSRDLPTVAKALAFTGKTALLKGRSNYLCLERLEQQALAGGDLPVQTLSDVILLRSWSNQTRDGDISTCVSV AEDSQAWPLVTSTNDNCLGSDCPLYKECFVVKARKKAMDADVVIVNHHLFLADMVVKESGFGELIPQAEVMIFDE AHQLPDIASQYFGQSLSSRQLLDLAKDITIAYRTELKDTQQLQKCADRLAQSAQDFRLQLGEPGYRGNLRELLAD SRIQRAFLLLDDTLELCYDVAKLSLGRSALLDAAFERATLYRSRLKRLKEINQPGYSYWYECTSRHFTLALTPLT VADKFKEVMEQKPGSWIFTSATLSVNDDLHHFTARLGIEQAESMLLPSPFDYTRQALLCVPRNLPQTNQPGAARQ LAAMLRPIIEANNGRCFMLCTSHAMMRDLAEQFRATMTLPVLLQGETSKGQLLQQFVSAGNALLVATSSFWEGVD VRGDTLSLVIIDKLPFTSPDDPLLKARMEDCRLRGGDPFDEVQLPDAVITLKQGVGRLIRDADDRGVLVICDNRL VMRPYGATFLASLPPAPRTRDIARAVRFLAIPSAE Salmonella typhi NYSGXRC-6013f SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MIEKTFSQQGALGQAIPGFQPRQAQVDMAKAVASAIANQSQLVVEAGTGTGKTFAYLVPALLSGKKVIISTGSKNL QEQLFHRDLPLMVSALGFFGQVALLKGRANYLCLDRLSRQMVESHTPESDPTLLTQLVKVRSWASSTQSGDLGEC DDLAEDSPIIPTITSTNDNCLGKECASYQDCFVSKARRRAMDADVVVVNHHLFLADLAIKETGFGELIPEAEVFI FDEAHQLPDIASQYFGQSVSSRQVQDLAKDIELGYRTEAKDMRQLQKVSDKLVQAAMDLRIVLGEPGYRGNWREV LKVPTVAREVERLNEALQFALDVLKLALGRSQLLDTAFERATLILGRIRRVCDVSVTGYSYWYDTTPRHFSLHIT PLSVADKFREQIALKEGAWIFTSATLAVNEDFSHFTERLGLTPSAQFSLVSPFDYQQQAVLCVPRYLPEPNSSGL AEKLVRMLAPVIEHNQGRCFFLCTSHSMMRDLGERFRERLTLPVLMQGETSKQKTLAEFMELGNALLVATGAFWE GIDVRGDTLSCVIIDKLPFTAPDDPLLKARIEDCRLRGGDPFAQVQLPEAVITLKQGVGRLIRDKNDKGALIICD NRLVTRDYGGVFLASLPPIPRTRDLDVVTTFLQQLAITEINQRDS Vibrio cholerae NYSGXRC-6013g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0387 LTSLSPLAEPSADAGNGDAAALPDAPPTDLHHAELATLFADDGTLAQGIESYRPRTSQLTMAQAVANAIEAADSLI VEAGTGTGKTYAYLVPAMLWGGKVILSTGTKNLQDQLFLRDIPTVRKALNAPVSVALLKGRANYVCHYHLERTSQ NGRLSSRQDAAWLREINRFLKTTKTGDKAELSAVPENAPVWNLVTSTRDNCLGSECAYYKDCFVMRARKEAQQAD MVVVNHHLFFADVMLKDTGMAELLPAANTVIFDEAHQLPETATLFFGETISTNQLLELARDSVAEGLSHARDAVD WVAIAAPLERAARDLRLVFRQDGARLSMKQIDSDAALSKPFYEVLPKLEQALSDFTGALEAQAERAETIEQCHRR AVALCDKLEAWAAPRPAPAAKADGEAALEAEAPVDERVRWVEVFANAVQLHLTPLSIAPIFSRQRAGQPRAWIFT SATLSVRGNFTHYAAQLGLDRDRSMTLDSPFDYASQGLLYVPRDLPQPSDPRFTDAVLDAALPMIEAAGGKTFVL CTTLRAVNRAAERLTDEFAQRGWDFPLLVQGQASRTELLERFRALGNAVLVGSQSFWEGVDVRGEALSLVVIDKL PFAPPDDPVLSARMEALEKKGLSPFAVHQLPHAVITLKQGAGRLIRSESDRGVLMICDPRLVEKSYGRQIWQSLP PFKRTREADTAAGFLRSLGQAESAAFPADTSAADTSA Ralstonia solanacearum NYSGXRC-6013h SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0387 MPGPPLHCSTLLRPLSSRHDAPHACFSRALTVAMSLLSRASIEALSDGGLLARRLDNFVPRPGQQRLTAAIGEIFE QRNILLAEAGTGTGKTFAYLVPTLLSGLKTIISTGTRALQEQLYHRDLPRVRAALGVDLRSALLKGRTNYVCKYR LEQTCAAPHLGTAEQTTQLQRILTWSGHTQFGDMAELDTLPDDSPLLPLVTSTLDNCLGKDCPFWNECFVVQARQ RAQAADVVVVNHHLLLADLALKQEGFGEILPGAQAFIIDEAHQLPALAANFFGESFGMRPLQELGRDCMIEARSV AGAQAALQHSVWQLEQALRTLRAAMEGLPSRGTQSRLLAKPEVCEGFETLITALTSLHSLLVPLRSAAAGLDACA ARAQEALSRLLRWLGETAETSGFEGDPPPNNDVLWYELTQRSFRCQRTPMDVSAQLQAHRETSMAAWVFTSATLA VDGTFEHIARRLGLNHPMTLLQPSPFDWVRQALCYLPPGLPNPATHGFGVALIEALIPVLEASSGRAFLLFASHR ALREAATALRGGPWPLFVQGDAPRATLLDRFRVSGNGLLLGSASFREGVDVAGGALSVVVIDKLPFTAPDDPVFE ARLEAIRQEGGNPFFDEQLPQAVIALKQGVGRLIRSESDRGVLVLCDPRLLSKSYGRIFLDSLPSFPQTRNIAEV RAFFNGSNTAPTESRHDSPTSHREASGVHRIG Xylella fastidiosa NYSGXRC-6013i SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MNNRFVVIDIETTGQSVAQGDRIIEIGAVVIEDEEAVESFCTLVNPERSIPPFIEELTGISDEMVKGAPTFHQCIP ELMSMLEGGVFVAHNVHFDLSFLQKLLEHEGYGPLLVPIIDTVELSRILLPTEESYKLSALTEQLGLEHENPHRA DSDAKVTADLLLLLLQKLRQLPLMTLQQLELLSDSWISDMGPILRQLIEKKMHDHAREEEVFDIYRQLAIRKPVK MKPQEEEIITTTDTFQSFKDRITQEGGSLSKAFLTYEWRQGQLKMMEVVHEAFSNNEHVLIEAGTGTGKSLAYLL PAAYFAHMEKAPVVISTQTIPLQSQLLERDIPLLQKILPFPINVALLKGRNHYLSLWKFEQALARGCEQDSYDTI LAKAAILVWLTETERGDREELNLPTGPGSFWATVESDGVSSLGKYDPWFSRCFYQRARTQAAKADLIITNHALLC TDMVQKNGLLPSFKQAVIDEAHHFEEVASDHLGKQTDYYSLYYFIQRLGYGDKEGLLDRMFQLAAKEDVKLTVDE EKVKTILQECQLELDELFRMLHRYVLQNRSSSKSDVGRLSYRYESFREQGTLWEAILESGMRVHLMMKEGIKKLQ LVLTCFHDVYDQLSFFDQGLLTDAKGVIDRLQEEENNLYELLLESDPNAVYWIEIEPRGAKNATFLYSRPIEVGE SLADRFFATKKSVVLTSATLSIKGSFDYQMERLGLHDFGVRTESIPSPFSYKEQARLLLPTDIPAIKDVSEEEYA QEVAIKIWRIADCSSGRILVLFTSYEMLKQVYQYVKDLSMDDSLALIGQGITSGSRAKLMKAFKLHEKAILFGTS SFWEGIDLPGNELRCLVIVRLPFAPPDQPLLKAKLDKAEEEGKNPFRHISLPQAIIRFKQGFGRLIRTSQDKGSV FVLDKRIATTRYGRAFLESLPDVPVYKGTLESLIEAHKEWM Bacillus halodurans NYSGXRC-6013j SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MKQKRYIVVDLETTGNQASREDRIIQFAACFVESGKRLETYTTFLNPEKPIPAFIQELTGISPKDVKNAPLFEDVA PIIANLLEDTIFVAHNVSFDWTFLEREMTRAGISLGKMKKLDTVELARIMYPGIDSYKLQDLSDEFNLGHDKPHR ADSDAEVTADLLLLLLEKLENLPLPVIRQMTTISGSLKSYLPELLFEIEMRKERENKPLNPNFVEHRGIVIRKKE VEKPTYSRADLLEFPETDEAKMALFKKAGAPLYARSGQFEMMNLVFQAMKSGKHALIEAGTGIGKSLGYFLPAIY QAKQAELPVVISTYTNLLQAQLFEKDVPLLTKLTGFKVKASLLKGRDHYLNLFKFEQLLQEVDTQYDVVVTKLKL LVWLTETTTGDIDEVNLSSGGELFWNRMKHTGWFLSEKHDPWLAHDFYKFNIKQAKNADLVIVNHALLLNDHFSG RETLPKYAFAVIDEAHHFADSARMQGSFVLSYRKLKYFLNQLGSLEKYSLLTRLAMAFPEADSLYDLDIAAMKLS DAVEELFVLLKMQLNFARKNLQEVVLVENSEKDAWNDKVYYAAEKVLYLLKESEKNMETLLEQGKLEENELGEAE SAFLEEMYAFLLDWKNMAKQLEQMLHKKSPILTIYLQADKNHSISSIRLKAVLMEVEPTLGKEFFAKKESVIMTS ATLTVKGKFDYLRKSLGLEEEQIMEKCIPSPFDYKENARVMIPDDMPPIKDTPIERYTAELAKYIRHIAVKTNGR MLVLFTASDMLQKTYYHMKNEKSLEEYVVLAQGVSAGSAARLTKQFQMFDKAILLGTTSFWEGIDIPGEDLSCLV IVRLPFAPMDDPYTKAQISLRKERGENAFQTYSLPEAVLRFKQGFGRLIRRESDRGIVFVFDNRVDTTKFGKAFL ESIPSAPILKGKQADLLEEVSEFFKEG Listeria monocytogenes NYSGXRC-6013k SGX Pharmaceuticals 2003-01-30 active Selected HI0387 MLTDLEKNAIRDHYQNIGKNLPGFRPRASQREMIAAVANAFSRTLAREEGGEPPKREGESIAVIEGPTGVGKSLAY LLAGGIMAQTRGKRLIVSSATVALQEQLVDRDLPFLVEKSGLELTFALAKGRGRYLCPYKLYRLTQSNAQQNLLG FEAPAVLWDSKPKPEELKLLRDIADEFSARRFNGDRDTWPEKIDDAIWLKVTNDRHGCLKTACPNRPECPFYLAR DVLETVDVVVANHDLLLADISMGGGVILPAPENSFYCIDEAHHLPKKALSRFAAEHSWNIAVWTLEKLPQLTGKI AALTDKAELANLADEAAASLLDSLHEWQFHLAEEPSLSLGVSENDRRTNSEPTWLWEDGKIPEGLETTVSNTAIA ARSLLKHVIGLNDALSAARREKEQDGALLDRLTSEFGLFIARIEQISAVWDLLSTVPLEGEEPLAKWITRRADDK NDYIFNASPISSASHLANSLWRRAAGAVLTSATLQSLGNFNLMLRQTGLQWLPETTTLALKSPFDFEKQGELYIP PIYASPKDPEAHTAAVIEWLPKLISPTEAIGTLVLFSSRKQMQDVALRLPGDYLPLLLVQGELPKAVLLQKHHRA IEEGKASIIFGLDSFAEGLDLPGTACVQVIIAKLPFAMPDNPIEKTQNRWIEQRGGNPFIEITVPEAGIKLIQAV GRLIRTEQDYGRVTILDNRIKTQRYGQQLLAGLPPFKRIG Neisseria meningitidis NYSGXRC-6013l SGX Pharmaceuticals 2003-01-30 active Selected HI0387 VKVELYYDKGTVLIKGRVHIPMAKWDERVKAYRALAYKYKDIVEFLKSEGVDFEDHVIDNIIPSPIYDVEFDFELR DYQREAVKKFMRVGRGIIVLPTGAGKTIVALEIIRRLSVSTLVVVPTLALLEQWKERLSIFGEIGEFSGRKKELK PITVTTYDSAYINAELLGDKFLFLVFDECHHLPSEAYRNIAQMSIAPYRLGLTAFPERADNLHELFPELIGGIIY EKRPSELVGKYLANYEVVRIHVPLTREEREEYRKYYERFKRYVEKRGIQFTSLKDFQRIVLSTANDNEAFKALRA LEQARKIAFNSTKKLEKLREILERHRGEKIIIFTRHNDLVYLISRKFLIPAITHKTYKAERSEILRKFRKGAYKA IVSSQVLDEGIDVPDASVGVIISGTGSSREFIQRLGRILRPAPGKEKAILYELISSGTSEVRISKRRRSSI Pyrococcus furiosus NYSGXRC-6014a SGX Pharmaceuticals 2003-01-30 active Selected HI0400 MTVKCKAEESLTCSCVDVGTIIDGSDCSVEVHQFYSTEADANAVLERLTKKARNTESDPCEIKSEIVAVENGVQLN ASFTFSCQAEAMIFELANR Haemophilus influenzae NYSGXRC-6014b SGX Pharmaceuticals 2003-04-23 active Selected Cloned Expressed Soluble Purified HI0400 ICEDB: T969 GENBANK NP_754770 VHIQRKSTMSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFANRAEAEQTLAALTEKARSVESEPCKITPTFTEE SDGVRLDIDFTFACEAEMLIFQLGLR Escherichia coli NYSGXRC-6014c SGX Pharmaceuticals 2003-05-30 active Selected Cloned Expressed Soluble Purified HI0400 ICEDB: T972 GENBANK NP_456931.1 MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFATRAEAEETLAALTEKARSVESEPCQITPTFTEESEGVRLDI DFVFACEAETLIFQLGLR Salmonella typhi NYSGXRC-6014d SGX Pharmaceuticals 2003-01-30 active Selected HI0400 MKDVVDKCSTKGCAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAAASSADEGASVAYKIKDLEGQVEL DAAFTFSCQAEMIIFELSLRSLA Shigella flexneri NYSGXRC-6014e SGX Pharmaceuticals 2003-05-30 active Selected Cloned Expressed Soluble Purified HI0400 ICEDB: T973 GENBANK NP_233304.1 MSNQTCVENEVCEACGCAGEIGFIIREGDDVAEVSLFGSDKAHLEGKLAEYISLAKQVYANVEYEVAPVADNATEL HARFKFEVSAEKLIFELKTRALAR Vibrio cholerae NYSGXRC-6015a SGX Pharmaceuticals 2003-03-07 active Selected Cloned Expressed Soluble Purified HI0423 ICEDB: T979 GENBANK NP_438584.1 VRSIYEKFMSRFTFKQFHINQNSCAMKVGTDGILLGAWADVKHCKNILDMGCGTGLLALMLAQRTEENCQIQAVEL DPIAAKQAQENINNSVWKNRIQLTQVDIQHFLQTTEQTFDLIVANPPYFEQGIACKNEERELARYTKQSHLNWLE WAATRLSENGRISFVLPYEAGKTLTKSTALFCIKQTNVITKIGKTPQRMLLTFAKQPEVLMQDQLVIYDADNQYT EAFIELTKDFYLKF Haemophilus influenzae NYSGXRC-6015b SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MRFKELILPLKIEEEELVEKFYEEGFFNFAIEEDKKGKKVLKIYLREGEPLPDFLKDWEIVDEKITTPKDWIVELE PFEIVEGIFIDPTEKINRRDAIVIKLSPGVAFGTGLHPTTRMSVFFLKKYLKEGNTVLDVGCGTGILAIAAKKLG ASRVVAVDVDEQAVEVAEENVRKNDVDVLVKWSDLLSEVEGTFDIVVSNILAEIHVKLLEDVNRVTHRDSMLILS GIVDRKEDMVKRKASEHGWNVLERKQEREWVTLVMKRS Thermotoga maritima NYSGXRC-6015c SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMGTGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQ EEAKKSGVSSLISFDLEDVHHLSYADQYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLE IMRKQIKEPEYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQNDQSTDHE IESVTWMLTIEKEKEGAL Bacillus subtilis NYSGXRC-6015d SGX Pharmaceuticals 2003-01-30 active Selected HI0423 LVMILIKLEIDRRAYNSIKNFSRLVYTKAIKNRGDLPKKEEIVTLTYNGKFVAKALYNPKSVILKILTTEDEEIDY DFFYKRIFNAKIYRENILNYKNTYRWIYAEGDELPTIIFDKYNELGAMQLMSKLIEKEYLKDIVDILFELSDLET IYVKRGKKGERIRDKIFGDKNKFETVIKEGDAKFKVNVRGHKTGFFLDQRENRLYLEKFIKEGDRVLDICCYTGG FSVHAAIRGAEVVGVDLSKKALKLAEENIELNNIPKDRYEFIEGNAFEVMKEMIEDKEKFDVVILDPPAFTQTED DIKNALRAYASLNYLGIKLAKRIFVTCSCSHHVDKEMFKRTVISSAFRAKKELIMIDYKGQAPDHPISIGNKNLE YLKCIFFYVKN Methanococcus jannaschii NYSGXRC-6015e SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MSKEAGHTFLAKLGKTRLRPGGKEATDWLIQQGAFSQDKQVLEVACNMCTTSIYLAHTYGCHIQGVDINKKALEKA QENISAAGLESYIQVQQANAVKLPFDDNQFDIVLNEAMLTMLPIAIKEKALREYYRVLKPGGILLTHDIVIVNES HATHVVKSLSAAINVNVSPQTKLGWLDLYHQAGFNHVHYHTGPMSLMTPKGLIYDEGIVGTIKIIKNALKKENRP MFCKMFKTMTKLRKDMNYITFVAKKED Staphylococcus aureus NYSGXRC-6015f SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MSQSGSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVADVKRILDIGTGSGLLALMLAQRTDDNVPIDAVE LDAGAAMQAQENVAHSPWPHRITVHTDDIQRWAPRQTVRFDLIISNPPYYEPGVECATPQREQARYTATLDHQTL LAIAADCITEDGFFCVVLPEQIGNAFTQQALNMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGS DQHYSESYTALTQAFYLFM Salmonella typhimurium NYSGXRC-6015g SGX Pharmaceuticals 2003-01-30 active Selected HI0423 VWGADYRRYGCNLHLFVWISLLGYCSHPVLSPFFLQGFIFMSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILL GAWAPVAGVKRCLDIGAGSGLLALMLAQRTSDSVIIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQ QTVRFDLIISNPPYYQQGVECATPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGW HLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM Shigella flexneri NYSGXRC-6015h SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MKTNKLINKSFRFKQFSIEEGTCGMPISTDGVLLGSWAFSLSPTTILDIGCGTGLLSLMCAQRFPHAHITALDIEQ TAYLAAEHNRQQSPWAERIECQHADILHWQPSKRFAAIICNPPYFNSGETAQHQVRATARHTISLQHQALIERLP QLLEPDGVASFILPKAEGEDFIALARQAGLFVGRYCQVQPTTDKPVHRLLFELHLSPCLPVETRLVIREQQGYSE AFCQLTRDFYLKMS Vibrio cholerae NYSGXRC-6015i SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0423 MPTDIFSFKQFDIDQTGCAMRVGTDGVLLGAWAGEDAAGSIPQHCLDIGTGTGLIALMLAQRFPQARVQGIEIDPI AAECARANAAASPFSDRIVIASGDILDSSLESLIGNQRFDLIVSNPPFFKSSMHAPDRQRTMARHEETLPLEKLI CRASELLSPQGRLALITPRDRLKDLRLYAATYRLVSSRLTEVRTLPHKEPKRLLSEWRPADTAIDRSPFTDTLII HPATGYYSPEYVRLTEPFYTTSFRILAVG Porphyromonas gingivalis NYSGXRC-6015j SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MVHIMFNQAAQELTTIRDILRFAVSRFNEAGLFFGHGTDNAHDEAAYLILHTLNLPLDMLAPYLDAKLLEAEKEEV LAVIERRAVEHIPAAYLTHQAWQGEFDFYVDERVIIPRSFIYELLGDGLRPWIEYDELVHNALDLCTGSGCLAIQ MAHHYPDAQIDAVDVSLDALEVAGINVEDYGLEERIRLIHTDLFEGLEGTYDLIVSNPPYVDAESVELLPEEYLH EPELALGSGADGLDATRQILLNAAKFLNPKGVLLVEIGHNRDVLEAAYPELPFTWLETSGGDGFVFLLTREQLLG EE Neisseria meningitidis NYSGXRC-6015k SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MTNRQANVVSGLQLWQWRIKANQAAIAHNIPIAEVDWLLQEIADLDRLALRLESFKDWSEVPMGLSLDKLDQLWQR RLGDRLPVQYIAGVTPWRKFKLTVSSAVLIPRPETECLIDLAVAAVANSESAMHLQQGHWVDLGTGSGAIALGLA DAFPEATIHAVDCSVEALAIAQQNAWNAGLFDRMRFYQGRWWEPLSLLKGQFNGMVSNPPYIPSDIVPTLQPEVV NHEPHLALDGGADGLDAIRHLIEVAPSYLRPGGIWLIEMMAGQADAVQALLLQQGSYSNIQIHSDLAGIERFALA QIQ Nostoc sp. NYSGXRC-6015l SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MSANRTALYGLPDHDLAPCASDAVQLSPLIVGSTDLATVADETFDAVTARAPAGAVERRYVLAHALRTLSPGGRLT VFAPKDRGGLRLKKELQALGCEVGESARRHNRICVCLRPSLIPGLEDALKAGAPRRIAENGLWTQPGVFSWDRLD AGTNALLQVLPAFSGVGADFGSGIGLLALNVLASPKVTKLTLVELDHRAVEVSRRNVTDPRGEIVWVDARQTGLK DLDFVVSNPPFHEGGGEDKALGQAFIRAAAEALRKGGSLWIVANRHLPYEAILGESFSKVRLVGEGGGYKVFEAK K Caulobacter crescentus NYSGXRC-6015m SGX Pharmaceuticals 2003-01-30 active Selected HI0423 VEGAAAALTVLRAAGLDAHATTPGEDLSARWPERARTVALVLAGDRGNAYAQAQVAWAHACTPPGGTLYLAGDRDK GFDRYVRQAGAAFGSGEVVARDGGMRVAKLVRRPGPTPPLPEPETYEAFGVKVVGLPGVFSAAKPDKATAILLTH LADLDLTGQRVLDLGCGAGLIGAWAASRGGQVTLVDGDLQSVRSSERTLAANALPGEVIHSDVDAALGERQFDVM LTNPPFHVGRGVVLDVAREFIATAGRRLVPGGRMFLVANEPLPYEQALGALGTVREVVREQGFKVLELRRAE Deinococcus radiodurans NYSGXRC-6015n SGX Pharmaceuticals 2003-01-30 active Selected HI0423 MDKDWFEVSVITSSEAVEAVTGILYNTPVKGVAIEDSKDVEFKKKHPGDWDYFDESLLNVKDGAVIKAYYKDDHNF DESVKYIEESIDKLSEFGINKGEGKVFVNKVNETDWENNWKKYYKPTKIGARIVVKPLWEEYTPKDYELMLNMDP GMAFGTGTHETTRMCIQALERYVNEDAEVFDIGTGSGILAIAAAKLNAKKVLGVDLDSVAVKAAKENIQYNNVNN IEILHGNLMEVVQGKADIIVANIIADVINILIPDINKFLKTDGYFISSGIIKDRAEDVIENLKKNKFEIIEVNNQ GEWICIVAKL Clostridium acetobutylicum NYSGXRC-6015o SGX Pharmaceuticals 2003-01-30 active Selected HI0423 VSEIRLYVTTTEIKAGEILDLMSDYFGEEDVAIATTEVDEKRDIWEASVYLMAEQEEEFRERVSTLLAPAFPGLVI EKEIIPDVDWIAKSLEGLKPVRAGRFIVHGAHDRDKVQPHDLAIEIEAGQAFGTGHHGTTAGCLEMIEDVLRARK VRNALDLGTGSGVLAIAVRKMRPIPVLATDIDPIAVKVAKENVRLNGIVSGMALETAPGFHSDAFRKHGPFDLII ANILARPLIKMAPQLVTHLAPGGTVILSGILASQRWKVLSAYNGAKLSHIRTIWRNDWVTLHLRKD Agrobacterium tumefaciens NYSGXRC-6016a SGX Pharmaceuticals 2003-01-30 active Selected HI0466 MSQFISLTQYQLIEVQGADAEKYLQGQLTSDVVRLASGATTLTAHCDPKGKMNAIYRLFKVSSEQFFLLVKKDILP SGLDALKKYAVFSKVSFDLRDWQIIGVIGEKCGKITPNFSLEIDEKRSILLNETELPVNFNGDEKIWEVADIQAG LPNLSPQTQNEFIPQALNLQAIEQAISFTKGCYIGQETVARAKYRGANKRAMFIFKVQTQQEAEIGSEIEMQLEA NWRKTGTITSAVNLDGVLWLQVVMNNDIDSEQQFRLLNSEILLERVQLPYSITE Haemophilus influenzae NYSGXRC-6016b SGX Pharmaceuticals 2003-01-30 active Selected HI0466 MAFTPFPPRQPTASARLPLTLMTLDDWALATITGADSEKYMQGQVTADVSQMAEDQHLLAAHCDAKGKMWSNLRLF RDGDGFAWIERRSVREPQLTELKKYAVFSKVTIAPDDERVLLGVAGFQARAALANLFSELPSKEKQVVKEGATTL LWFEHPAERFLIVTDEATANMLTDKLRGEAELNNSQQWLALNIEAGFPVIDAANSGQFIPQATNLQALGGISFKK GCYTGQEMVARAKFRGANKRALWLLAGSASRLPEAGEDLELKMGENWRRTGTVLAAVKLEDGQVVVQVVMNNDME PDSIFRVRDDANTLHIEPLPYSLEE Escherichia coli NYSGXRC-6016c SGX Pharmaceuticals 2003-01-30 active Selected HI0466 MADPAFHTPLVHEGILAVRGPDAAKFLQGQLTCNLAYLNDETSSLGGRCNIKGRLLSSFRILPEGDGLLLAMAGEL LEAQLADLKKYAVFSKASLADESAAWLRIGLRDASEALRALGIDTPAESGRIARHGDLLAVALGDGRVELWVPAQ RAEAVLATLREHSREAPLDDWLLGQVRAGIGQVFGATRELFIPQMINLQAVGGVSFKKGCYTGQEIVARMQYLGR LKRRLYRLALDADEVPAPGTGLFSPVHSTSVGEVVLAARTPENSVELLAVLQDDAVADGRISLGSAEGAPLVLLN LPYTLDSDREIQR Pseudomonas aeruginosa NYSGXRC-6016d SGX Pharmaceuticals 2003-01-30 active Selected HI0466 MAFISFPPRHPSSSARLPLTLIALDDWALSTITGVDSEKYIQGQVTADVSQMTEQQHLLAAHCDAKGKMWSTLRLF RERDGFAWIERRSVLEAQLTELKKYAVFSKVVIAPDDERVLLGVAGFQARAALANVFSELPNSENQVVRDGASTL LWFEHPAERFLLVTDVATANMLTEKLHGEAELNNSQQWLALDIEAGIPVIDAANSGQFIPQATNLQALGGISFKK GCYTGQEMVARAKFRGANKRALWLLAGKASRVPEAGEDLELQMGENWRRTGAILAATQLDDGQLLVQAVMNNDLE AESVFRVRDDANTLHIVPLPYSLEE Salmonella typhimurium NYSGXRC-6016e SGX Pharmaceuticals 2003-01-30 active Selected HI0466 MDWQNRFSVLNLSSHDPLPELMLTHLTGWGAITLVGADKKAYLQGQVTCNVVSLQEQQVTFGAHCDAKGKVWSVFR LFHHHDGYAMFQPQSAMEVELRELKKYAIFSKVTIAESSDIALGVMGSQADAWIDTVSETTGDVRRIAGGTAVRM SPQRWLLLVNAEQAEQYVNAWQGLHVEQSLWTRMDIEEAVPVVTQTAQNEHIPQALNVQAVDGISFTKGCYTGQE TVARAKYRGINKRAMYIVKGNLSAPLSQDEPVVLERAVGENWRSAGALLTHYRFTDSIAIGLIVLPNDLEHDVKL RLAAQPDTRWHIQPLPYSLSDE Vibrio cholerae NYSGXRC-6016f SGX Pharmaceuticals 2003-01-30 active Selected HI0466 MTAPCLARLASRAVIAVSGPDWRSFLQGLLTQDVETLAVGELRFAGLLTPQGKLLYDLFVAGAEDGALLDVAAAHR DAILTRLSMYRLRAKVELVASDRPVIAVFGGATSGEGLYADPRLPALGARAYDDRATNADEDVYEAHRLALGVPG PTDWGSEATYPIEANFDLLAGIDFKKGCFVGQETTSRMKRRGTIKNRMLPITFDGPPPPFGAEVLAGELRAGEVL SGRDGQAMALLRLDRIEGVALTVEGRPVRVERPDWVA Caulobacter crescentus NYSGXRC-6017a SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MIYSMTAFARLEVKKDWGDAVWEIRSVNQRYLENFFRLPEQFRGLENTLREKLRQNLTRGKIECSLRIETKKQANA ELNLNKELANQVIQSLQWIKAQAGEGEINLTDVLRYPGVVEAQEQDLDAISQDLLTAFDDLLTDFIAMRGREGEK LNDIIQQRLDSIAVETDKVRSQMPAVLQWQRERLLQRFEDAQLNLDPQRVEQEMILLAQRIDVAEELDRLQMHVK ETTNILKKGGAVGRKLDFMMQELNRESNTLASKSINADITASAVELKVLIEQMREQIQNLE Haemophilus influenzae NYSGXRC-6017b SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MVHSMTAFARVEQAGTHGTLSWELRSVNHRYLEPHLRLPDAFRDLEGAVREALRQGLSRGKVECTLRFAEETAGKS LQVDQERARQLVAAAEGVAALIRQPAPLDPLAVLAWPGVLVADSADPQALNAAALEAFGQALEQLKAGRSREGLE LAKLLNDRLDAMLVEVGNLRELVPTMLANQRQKILDRFAELKAELDPQRLEQELVLLAQKSDVAEELDRLATHVG EVRRVLKAGGAAGRRLDFLMQELNREANTLGSKAFDPRSTQAAVNLKVLIEQMREQVQNIE Pseudomonas aeruginosa NYSGXRC-6017c SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLYFEDKLKQTILQHIQRGRIELFVSVDSDMLVEK RLEIDWPLLDEFVAAARDMKKRYQLSAEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKE GLLLAKDCLMHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDITEEITRLK SHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEMKSSIEKIKEQVQNIE Bacillus subtilis NYSGXRC-6017d SGX Pharmaceuticals 2003-01-30 active Selected HI0467 VIKSMTGFSRVEKVSGPYQFRVEMKSLNSKGLNIINQLPGYLSMKEIELNNLVQEYVSRGKVQTRVQVKFLEPPKV LEIDKNVVRAYYSMLDEIVGELSLPEPVKLSDLLNFREVFRIELSDEEIENIWNHLVPILREALEKLVEERKKEG QKIGADLKRILEDLSSRVEEIEKISDQLPALYREKIKEEVEKILPQDVSVKEDILENHVAFMATKADIREEITRL RSHIKRALELIESDEPVGMNLDFLGQEMLRELNTILSKSISGEITSLALEGKVLVSQFREQIQNVE Thermotoga maritima NYSGXRC-6017e SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MKSMTGFGKKTIQNENYQLDIEVKSVNQRFLDIQLRMPKELNAYELVIRQVIKRTLKRGRVEVYVNLQKIGNNQKE VRVQWDLIDQLLTSVDQHLKEKYPEATFDAGDTVNHLLKQNDFVEIVEAEIVDQTFEPFLVQAFEAAIASLDQSR VQEGTQIKQVLLDYVAVLTQSIQELQAFVGVFEQEYRQRFEAKLNEWLGSQVDETRLLTEMAILLEKGDIHEELD RLDIHIDKLHQLLDETEPVGRELDFLIQEMNREVNTIGSKSSPIEIKNSVVQMKTTLEKIREQIQNVE Enterococcus faecalis NYSGXRC-6017f SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MIYSMTAYARKEVKGDWGSAVWEIRSVNQRYLETYFRLPEQFRGLEPLLRERFRQRLSRGKIECHLRFEANPAAQS HLTINEGLAQQVINAANQIMHMTGELSRINPFQVMQWPGVMETPEQDMDAINQALLSAFDEGVDEFIAARGREGD NMKALIEQRLQAISAEVVKVRARMPEILEWQRERLFSKFEEAKIELDASRVEQELILLAQKSDVAEELDRLDSHV KEAREVLKKGGSCGRKLDFMMQEFNRESNTLASKSISTDITASGVELKVLIEQMREQIQNIE Vibrio cholerae NYSGXRC-6017g SGX Pharmaceuticals 2003-06-06 active Selected Cloned Expressed Soluble Purified HI0467 ICEDB: T1006 GENBANK NP_458191.1 MIRSMTAYARREIKGEWGSATWEMRSVNQRYLETYFRLPEQFRSLEPVVRERIRTRLTRGKVECMLRFEPDASAQG ELILNEKLAKQLVSAANWVKMQSDEGEINPVDILRWPGVMAAQEQDLDAIAAEILAALDGTLDDFIVARETEGQA LKALIEQRLEGVSAEVAKVRAHMPEILQWQRERLVAKLEDAQVQLENNRLEQELVMMAQRIDVAEELDRLEAHVK ETYNILKKKEAVGRRLDFMMQEFNRESNTLASKSINADVTNSAIELKVLIEQMREQIQNIE Salmonella typhi NYSGXRC-6017h SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0467 MGALGYHPYFESNMIHSMTAFAADEHLTPWGLLACELRSVNHRFLDIVIRLPEELRALEPQLRERVAARVSRGKLD LTVRLSPQEIHTGKLVVNELLLSQLSTLALRLSAQFPALRVTFAELLQIPGVLKGEQIDMATLQGHAVALLDKVL NNFIATREREGLKMQAMIAQRASAIERIVGEVRILIPTIREGQHNKLSARMNHLSYPVDPGRIEQELVLWLQKLD VDEELDRLSSHISELHRILQQREPVGRRLDFLMQEFNREANTLGSKSVDSRTSNATIELKVLIDQIREQVQNIE Xylella fastidiosa NYSGXRC-6017i SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MIRSMTGFGRASNDNGRLGFNVEIKSVNHRYFDLNIKLPRNLISLEEKIRKEVGNKIKRGKVDIFITQNVYDSSTT NVNLNKGLAYNYCECLKQIRDDFNVLDDISVSLISKFPDVITVTQNEEDLDEISSLLLKPINEAVDTMLSMREKE GARLKEDIEGKLTNIEELLVNVEKRAPYTVENYRNKLEERIKDLLVDNQVDEAKLAMEVTIFADKSCIDEEIVRL KSHISQFKSTLSKNEPVGRKLDFIVHEMNREANTINSKSNDIDIVHCVLDIKNEIEKIREQIQNIE Clostridium acetobutylicum NYSGXRC-6017j SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MSSGNIHIHSMTGFANAAAECGSKRINLDLRAVNHRFLDIQIRMPDDLRYLESGIREKISSHIARGKVECKIQIQD AENGSQSLELNRDLVGQLAEINKDLRKHHDLAKLGVADILRFPGVLASQRENTEELAKSITELTEKALKDFTAAR KREGKKLGEHLLQRLEAMEEIIDALSELFPTLLETHKEKIRARLVEAVGSIDNDRLQQEFALFIQKSDIDEEFSR LRTHIAEVRRIVTEHKGSSGKRLDFLMQELNREANTLGSKSIAAECTQASVELKVLIEQMREQVQNIE Neisseria meningitidis NYSGXRC-6017k SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MIASMTGYGFASIEGDAFKATVELRSVNHRFFEWNCRLPRPLSFLEEELKKIAKNAVQRGKLDVFIKIEGEALTKR ELEVDWDLLKQYEAASRKIAQTINQEHVLDIPSLLFSDQLVQVNEAGEVDEELIQVIKQAMEKAVHDLRHMRMEE GSHLKQDLDVRLNIMSELVEQIDTYSPEVVDHYRDKLRKRVNEFLSGFESQLDESRLLAEVALFAEKSDISEELT RLRSHIEQFANILSGGGVVGRKLDFLVQEMNREANTIGSKANHLAIRRHVVEMKSEIEKMKEQVQNIE Bacillus halodurans NYSGXRC-6017l SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0467 MIHSMTGYGVATRQAAFTDHSGAPCDNVATVSVEFRTVNSRFLDLLFRAPEECRAFEPALREMLMSALSRGKLECR INLQRQEAAGDVAALNVGVLQQLATLEQEVARHLPAAGSLRMGEVLRWPGVLAEPELTQDALREAVTAAAKEALQ QLLESRRREGEALKAMLLERVDAMLSIVEDLVPMVPNLIQQHQDKLTERLREAFGLAAPDGTPALTRDELTERIR QEATVYGIRIDIAEELSRLQAHLRETRHILEKGGQIGKRLDFMMQELNREANTLGSKAAAKELADASMELKLLIE QMREQVQNLE Ralstonia solanacearum NYSGXRC-6017m SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MTLQSMTGFARSEGTSGRYRWAWELRSVNGKGLDVRLRLPTGLEALETGLREIASEHLSRGNIQAGLTLAIAENRL EAVINRDALAAVLALKKELGDVVDDKPLSFDTLLTLRGLVDFREAEDDAEAQAARNGEVLAGFAAAVEKLKDMRE REGASLFAILSGHINRIEQLVDIIENDPSRQPEQIAARLAQQIALIGDGMHGLDRDRLHAEAALIATKADLREEI DRLHAHVQASRELLENGGPVGRKLDFLAQEFNRESNTICSKSNASAVTAAGIELKVVIDQFREQVQNLE Agrobacterium tumefaciens NYSGXRC-6017n SGX Pharmaceuticals 2003-01-30 active Selected HI0467 MVKSMTGFGRATKEFEAFKVTIELKAVNHRYSEFLFRMPKQLAYLEGKLKKTISKQIKRGRIEVFFSITGEQIAKR ELHIDWDLADSYYRFIKQASARYELQELPTMGDLLQEQAYLSIEEEVEASSELERLVLETLARATERLDEMRSME GAELLLYFKQHLAALENSLEIIQAEIPNTEKHYQEKIETRLQNVVGDQFDPSIVLTEVAMLLEKADINEEVERTK SHLKQFYGIILLEEPIGRKLDFLIQEMNREVNTIGSKASSLKITEQVVEMKTTLEKIREQVQNVE Listeria monocytogenes NYSGXRC-6017o SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0467 MLESMTGYGSAERSEKGMKVLVELRSVNNRFAEIGVKLPRQLLSWELEVRELIRASFQRGKISAFVQLQLEEAEAL PVTVNPSKVRGYKALLETVRREAEIEAPVTLDHVLRFSEIFEPDHTILEHPDEIWPIAQSALIEAIGNLKEMRRK EGEELAIDFLSRIDEIERTLKEIKEIAAGNLETIRKRLASKISAIAGCDVEYSKDRLEMEIVMAAERLDITEECI RFSSHNKFFIEELNNSSSGSGRKLNFLLQEQLREANTIASKSQNADISQKVVHIKEELEKVREQLQNIE Chlorobium tepidum NYSGXRC-6018a SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MNDLTLSPIAIIHTPYKEKFSVPRQPNLVEDGVGIVELLPPYNSPEAVRGLEQFSHLWLIFQFDQIQQGKWQPTVR PPRLGGNQRVGVFASRATHRPNPLGLSKVELRQVECINGNIFLHLGAVDLVDGTPIFDIKPYIAYADSEPNAQSS FAQEKLPVKLTVEFTEQAKSAVKKREEKRPHLSRFIRQVLEQDPRPAYQQGKPSDRIYGMSLYEFNVKWRIKAGT VNCVEVIEIEKDK Haemophilus influenzae NYSGXRC-6018b SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MTHSVSPIGYIRSCFMEKFAIPRQPLLAPAARGTLELLPPFDQVEALEGLEQVSHVWLLFLFHQALEDKPRLKVRP PRLGGNRSLGVFATRATHRPNGIGQSVVRLEGFEAGRLWLSGIDLLDGTPVLDIKPYVPYADAVADARNGIADAP PPGIAVEWSEQARRQAHEHGQRLRQPVAELIEQCLAQDPRPAYQKPEPGRRYGVRLWDLDVHWHYPRPDLIRVLD VAGGD Pseudomonas aeruginosa NYSGXRC-6018c SGX Pharmaceuticals 2003-01-30 active Selected HI0510 VFLLKQIGVIRSPFKSPSECPFQGRFSQERFTIELFPEYEEGLKDIETCTHLIVLYWLDRANRDRLIAIPPFDKRE HGVFATRSPHRPNPIGFSVVKLLEVRGRELVVEGLDAVDGTPVVDIKPYSSKIDCVENARIGWFEEV Thermotoga maritima NYSGXRC-6018d SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MSSFQFEQIGVIRSPYKEKFAVPRQPGLVKSANGELHLIASYNQADAVRGLEAFSHLWILFVFHQTMEGGWRPTVR PPRLGGNARMGVFATRSTFRPNPIGMSLVELKEVVCHKGSVILKLGSLDLVDGTPVVDIKPYLPFAESLPDASAS YAQSAPAAEMAVSFTAEVEKQLLTLEKRYPQLTLFIREVLAQDPRPAYRKGEETGKTYAVWLHDFNVRWRVTDAG FEVFALEPR Shigella flexneri NYSGXRC-6018e SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MSSFQFDQIGVIRSPYKEKFAVPRQPGLVKSACGELHLIAPYNQADAVRGLEAFSHLWVLFVFHQTMDGGWRPTVR PPRLGGNARMGVFATRSTFRPNPIGMSLVALKGIECRKESVILKLGSLDLVDGTPVVDIKPYLPFAEALPDAAAS YAQQAPIAEMPVSFTAEVAQQLTTLERRYPQLRTFICDVLAQDPRPAYRKGEETGKTYAVWLHDFNVRWRVVNTG FEVFALEPR Salmonella typhi NYSGXRC-6018f SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MYPIEPIAIIESPYQEKFAVPRQPRLVPSATARVKLLGECNCAESIRGIEQFSHVWLLFLFDQNLAAGWKPTVRPP RLGGNERVGVFASRATFRPNGIGMSAVELKGVSKEGDQYYLELGSVDLVNGTPIIDIKPYIPYSDSITDAQGGYA EQEPQRMAVTFSDAARQMLQAHPEGKIRQAVIREVLAQDPRPAYKKHRADDKLYAVNLYDWNVKFTVNAEAIVVN AIEPF Vibrio cholerae NYSGXRC-6018g SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MTYTITPIGTARSPYKQKFGIARQPGLVSAAKACIELNPKFTADSVRGLEDFDYVWISFIFHGVLDEGWAQMVRPP RLGGKQKMGVFATRSPHRPNHLGLSLLKLERIETGKPVRLYCSGADLLDGTPIVDIKPYIPFVESKPDAASGFVS GKPVELEVVWQENIGAENLSANTKNLISQSIAQDPRPAYQNIPERIYVMNIADYEVRFQIEENRATVIDLSPTPL Neisseria meningitidis NYSGXRC-6018h SGX Pharmaceuticals 2003-01-30 active Selected HI0510 VMLVQLRQVGVIRSPYKNFSKAPHQGRFSKETVEIEIFPEFEDGLKDIETCTHLIVLYWLDRANRDALLVVPPHDS REHGVFATRSPHRPNPIGFAVVELLERDGRVLKVKGLDALDGTPVVDIKPYSSTIDSVGNAKIGWFEEANPQSKL TRLLLRAKEFHGHICPFVALGVRMSVIAMEKLGVEEDAMASVGEDILAIVECNNCLTDGVQVATGCTLGNNSLIY LDLGKNALTIVRRKDWKGVRVYVNAENVRKYFSKEALELFNKVIVRREGSEEDAKRLSEFWEETGWKMLEIPEEE FKVEFVEVQPIERAPIFENKRCEKCGELAMATRVKDGLCLRCAGSYYAVVGRGIVKFDGEMREVV Archaeoglobus fulgidus NYSGXRC-6018i SGX Pharmaceuticals 2003-01-30 active Selected HI0510 VVSGVEIVLRPIGFVSHGLPDSTVRENIGGVEGFIEVLPEYAPGLDGLAGFSHIIVIAYLHKSKGRALRVRPRGLL RLGFRLEDLPEVGVFATDSPSRPNPLALTIARLLDIEGRRLRVSGLDLYDGTPVLDIKPYTPSRRVEDLSLPSWY KELLEEASRRDPRVREV Aeropyrum pernix NYSGXRC-6018j SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MNACFKYIGFIKRNDNSTSRNAIIEIHVNKEYEEGLKGLEEFSHIIVIYHLHLASFDGRLLREKKGVTVGIFATRS QFRPNPIGISVAELIEIKGNIVLAKGINAFNNTPVLDIKPLSAVSDKP Sulfolobus solfataricus NYSGXRC-6018k SGX Pharmaceuticals 2003-01-30 active Selected HI0510 MKFEAFKIVPVGYIRKEKNVFIEILPEFREGMEGLREGDWIKLILWFHKSDTPELRRILKVHPHGNPENPLTGVFA TRSPFRPNPYTVKVHKIEGNRIYIDWIDAEDGTPVSDIKIFPERYDCPKENYQSTSRLKS Pyrococcus horikoshii NYSGXRC-6018l SGX Pharmaceuticals 2003-05-30 active Selected Cloned Expressed Soluble Purified HI0510 ICEDB: T1013 GENBANK NP_280026.1 MYATPIGYADTRFETAADAPRQGVETPYAANVQVYESFRGGLVGLEPDDRVVVVWWADDADRDVLAVRDGDRGVFT TRSPARPNPVCITPCELLAVDAADGTLAIRGVDMAHGSPVLDLKPALD Halobacterium sp. NRC-1 NYSGXRC-6019a SGX Pharmaceuticals 2003-01-30 active Selected HI0568 MLNQQISQIIAAELTVQPQQIFAAIQLLDDGNTIPFIARYRKEATGGLDDTQLRHFETRLIYLRELEDRRQTILKS IEEQGKLTDELRDKIHATQSKTELEDLYLPYKPKRRTKGQIAIEAGLEPLANLLWNEPKNDPESTALSFVDAEKG VADSKAALDGARIILMERFAEDAGLLAKVRDYLAKNAVIVSKVIEGKETEGAKFQDYFDHQELLKNVPSHRALAM FRGRNEGILQLSLNADPDAEEGSRQSYCEEIIRDYLDVRFTGQPADKWREQVIAWTWKIKVSLHLETELMASLRE KAEEEAIDVFARNLTALLMAAPAGAKSTMGLDPGLRTGVKVAMVDNTGKLLDTTTIYPHTGREAEAQVAIFSLIR KHNVELIAIGNGTASRETERFAKDVIKEIKENKPQTVVVSEAGASVYSASEFAANEFPNLDVSLRGAVSIARRLQ DPLAELVKIEPKAIGVGQYQHDVNQTQLARKLDAVVEDCVNAVGVDLNTASAPLLARVAGMTKTLAQNIVEYRDE NGRFESRSELKKVPRLGPKAFEQCAGFMRIANGKNPLDASGVHPEAYPVVEKILQATAQSIQDLMSNAGVVRQLD AKQFIDEQFGLPTVQDIFKELEKPGRDPRGEFKTAVFAEGVEEITDLKSGMILEGTVTNVTNFGAFVDIGVHQDG LVHISSLSDKFVEDPHQVVKTGNIVKVKVLEVDVPRKRIALTMRLDESAVKNDSKSDRTLSTRPRGNMQREARNS RGNNVIGNAFA Haemophilus influenzae NYSGXRC-6019c SGX Pharmaceuticals 2003-01-30 active Selected HI0568 MAEAYNEEVVALLQKELTTYRSKQITTVLTLLNEGNTVPFIARYRKEMTGSLDEVQIREIEERYHYLQNLKKRKEE VLRLIEEQGKLTKELKTDIQKAVKMQQVEDLYRPYKQKRRTKATIAKEKGLEPLADWLLSLPENADILAKAATFI NEEKEVATAEIALQGAHEILAERISDEPKYRIWLRDYMVKHAQYVSVVKDEEKDEKRTYEMYYDFAEPVSKMVPH RVLATNRGEKEDILKVSLVADETKINDYFQRQLIGKQATSLAAPYIEAAYLDSYKRFIGPAIEREIRNELTEKAD EQAIAIFGENLRNLLLQSPLKGKVVLGFDPAYRTGCKLAVVDETGKVLAIQVIYPHKPATAAKREAAGPAFKKII EDYQVDMVAIGNGTASRESELFVAEQLKAVKRDVFYVIVNEAGASVYSASEVARKEFPDLQVEERSAVSIARRLQ DPLAELVKIDPKAVGVGQYQHDVSQKRLAEQLDFVVETAVNQVGVDVNTASAQLLQHISGLNKTTAQNLVTYRDE NGVFTARNQVKKVPRLGPKAFEQAIGFLRIPNGKNVLDNTGIHPESYPVAQAILEKAEIASKELGTAEAIEKLKQ LPVNQLATELEVGSETLTDIIASLIQPGRDMRDEMSAPLLRKDVLTMEDLKPGMEMQGTVRNVIDFGAFVDIGVK QDGLVHISKLSTKFVKHPTDVVAVGDVVTVWVEDVDLKKGRISLTMLPRADRKE Enterococcus faecalis NYSGXRC-6019d SGX Pharmaceuticals 2003-01-30 active Selected HI0568 MDNQLINSIIEKYQFSKKQIEAVLTLLEEKNTVPFIARYRKEQTGGLDEVQIKQIDDEYQYMVNLQKRKEEVIKNI EQQGLLTEELKKDILKQNKLQRVEDLYRPFKQKKKTRATEAKRKGLEPLAIWMKARKHEVSIEEKAQQFINEEVQ SVEDAIKGAQDIIAEQISDNPKYRTKILKDMYHQGVLTTSKKKNAEDEKGIFEMYYAYSEPIKRIANHRVLAVNR GEKEKVLSVKFEFDTTSVEDFIARQEINHNNVNRSYILEAIKDSLKRLIVPSIEREIHADLTEKAENHAIDVFSE NLRNLLLQPPMKGKQILGVDPAFRTGCKLAVINPFGTFIAKGVIYPHPPVSKKEAAEKDFVQMVKAYDVQLIAIG NGTASRETEQFVADLIKKHQLPVQFIIVNEAGASVYSASEIARDEFPDFQVEERSAVSIGRRVQDPLSELVKIDP KSIGVGQYQHDVNQKALENALTFVVETAVNQVGVDVNTASSSLLQYVSGLSSQIAKNIIAYREENGAIKHNKELS KIKRLGAKTFEQSIGFLRIVDGSEPLDNTSIHPESYKVTYQLLDKLGFGGNDLGSDALKAKLNSLDMDELAIELQ VGVPTLEDIIKSLKAPNRDPRDEFDTPILKSDVLSIEDLKEGMKLSGTVRNVVDFGAFVDIGVKQDGLVHVSKLS KKFVKNPMDIVSVGDIVDVWVYSIDKNKDKVSLTMIDPHE Staphylococcus aureus NYSGXRC-6019e SGX Pharmaceuticals 2003-01-30 active Selected HI0568 LWYNRFMDKKYEKISQDLGVTLKQIDTVLSLTAEGATIPFIARYRKDMTGSLDEVAIKAIIDLDKSLTNLNDRKEA VLAKIQEQGKLTKELEEAILVAEKLADVEELYLPYKEKRRTKATIAREAGLFPLARLILQNIVDLEKEAEKFVCE GFATGKEALTGAVDILVEALSEDVTLRSMTYQEVLRHSKLTSQAKDESLDEKQVFQIYYDFSETVGTMQGYRTLA LNRGEKLGVLKIGFEHATDRILAFFATRFKVKNAYIDEVVQQSVKKKVLPAIERRIRTELTEKAEEGAIQLFSDN LRNLLLVAPLKGRVVLGFDPAFRTGAKLAVVDATGKMLTTQVIYPVKPASARQIEEAKKDLADLIGQYGVEIIAI GNGTASRESEAFVAEVLKDFPEVSYVIVNESGASVYSASELARQEFPDLTVEKRSAISIARRLQDPLAELVKIDP KSIGVGQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTASPALLSHVAGLNKTISENIVKYREEEGKITSRAQIK KVPRLGAKAFEQAAGFLRIPESSNILDNTGVHPENYTAVKELFKRLDIKDLNEEAQSKLKSLSVKEMAQELDLGP ETLKDIIADLLKPGRDFRDSFDAPVLRQDVLDIKDLVVGQKLEGVVRNVVDFGAFVDIGIHEDGLIHISHMSRKF IKHPSQVVSVGDLVTVWVKKIDTEREKVNLSLLAPNETD Streptococcus pneumoniae NYSGXRC-6019f SGX Pharmaceuticals 2003-01-30 active Selected HI0568 METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKEQTGSMDEVQIQTISERWQYIQNLNQRKEEVIR LIAEQDKLTDNLKRKIEQSVKLQEVEDLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEE KEVFTREEAIEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPIAKVVPHRV LAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDSYKRLIQPAIEREIRKELSEKADEQA IHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGCKLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQV EMVAIGNGTASRETEQFIVNVLRDMPRKIYYVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQF IVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLAELVKIDPKSVGVGQYQHD VSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLSKSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYE QCIGFLRVQEGTEPLDRTGIHPESYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICE QLTRPERDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLSNQFVKHPLDVV SVGDIVTVWVDGVDVQKGRVSLSMVK Bacillus subtilis NYSGXRC-6019g SGX Pharmaceuticals 2003-01-30 active Selected HI0568 MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPARELSIKHDVDP NEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPAS LVEMRRVRDLQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNFGAFV DLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGKV TKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPA KYGMADSYDEQGNYIFPEGFDAETNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSSA SSAPSEKTAGGSLASDAQLAALREKLAGSA Mycobacterium tuberculosis NYSGXRC-6019i SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0568 VFIMRREFPEEGDIVIGTVKDVKPYGAFVELLEYPGKEGMIHISEVTSGWVKNIRDHVKVGQRVVAKVLRVDERKG HIDLSLKRVTEQQKRAKVQEWKRFQRASKMLERAAEKLGKSLEEAWEEVGYLLEDEFGELYNAFETMVIEGKEVL DDLEISEEWKNVLYEVAKESIELTNVEVEGVIEMKSYAPDGIKQIKKALTTALKANPYEDVEVKITYIGAPKYRV VVIAPDYKSGEEVFKKVCEKAVATIKKLGGEGTYYRESKK Methanococcus jannaschii NYSGXRC-6019k SGX Pharmaceuticals 2003-01-30 active Selected HI0568 MMNDSFCRIIAGEIQARPEQVDAAVRLLDEGNTVPFIARYRKEITGGLDDTQLRNLETRLSYLRELEERRQAILKS ISEQGKLTDDLAKAINATLSKTELEDLYLPYKPKRRTRGQIAIEAGLEPLADLLWSDPSHTPEVAAAQYVDADKG VADTKAALDGARYILMERFAEDAALLAKVRDYLWKNAHLVSTVVSGKEEEGAKFRDYFDHHEPLSTVPSHRALAM FRGRNEGVLQLSLNADPQFDEPPKESYCEQIIMDHLGLRLNNAPADSWRKSVVSWTWRIKVLMHLETELMGTVRE RAEDEAINVFARNLHDLLMAAPAGLRATMGLDPGLRTGVKVAVVDATGKLVATDTIYPHTGQAAKAAMTVAALCE KHNVELVAIGNGTASRETERFYLDVQKQFPKVTAQKVIVSEAGASVYSASELAAQEFPDLDVSLRGAVSIARRLQ DPLAELVKIDPKSIGVGQYQHDVSQTQLARKLDAVVEDCVNAVGVDLNTASVPLLTRVAGLTRMMAQNIVAWRDE NGQFQNRQQLLKVSRLGPKAFEQCAGFLRINHGDNPLDASTVHPEAYPVVERILAATQQALKDLMGNSSELRNLK ASDFTDEKFGVPTVTDIIKELEKPGRDPRPEFKTAQFADGVETMNDLQPGMILEGAVTNVTNFGAFVDIGVHQDG LVHISSLSNKFVEDPHTVVKAGDIVKVKVLEVDLQRKRIALTMRLDEQPGETNSRRGGGNERPQNNRPAAKPRGR EAQPAGNSAMMDALAAAMGKKR Shigella flexneri NYSGXRC-6019l SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0568 MMNDSFCRIIAGEIQANAGQVEAAVRLLDEGNTVPFIARYRKEITGGLDDTQLRNLETRLGYLRELEDRRQAILKS ISEQGKLTDELAGAINATLSKTELEDLYLPYKPKRRTRGQIAIEAGLEPLADLLWNEPSHDPDVKAAKYIDGDKG VADTKAALDGARYILMERFAEDAALLAKVRDYLWKNAHLVATVVSGKEEEGAKFRDYFDHHEPIANVPSHRALAM FRGRNEGILQLSLNADPQFDEPPKESYCEQIIMDHLGLRLNNAPADSWRKGVVSWTWRIKVLMHLETELMGTVRE RAEDEAINVFARNLHDLLMAAPAGLRATMGLDPGLRTGVKVAVVDGTGKLVATDTIYPHTGQAAKAATVIAALCE KYHVELVAIGNGTASRETERFYLDVQKQFPNVTAQKVIVSEAGASVYSASELAAQEFPDLDVSLRGAVSIARRLQ DPLAELVKIDPKSIGVGQYQHDVSQTQLARKLDAVVEDCVNAVGVDLNTASVPLLTRVAGLTRMMAQNIVAWRDE NGQFQNRQQLLKVSRLGPKAFEQCAGFLRINHGDNPLDASTVHPEAYPVVERILAATQQALKDLMGNSNELRHLK AADFTDDKFGVPTVSDIIKELEKPGRDPRPEFKTAQFADGVETMNDLLPGMILEGAVTNVTNFGAFVDIGVHQDG LVHISSLSTKFVDDPHTVVKAGDIVKVKVLEVDLQRKRIALTMRLDEQPGETAARRGGGADRAQGNRPASKAAKP RGRDAQPAGNSAMMDALAAAMGKKR Salmonella typhi NYSGXRC-6019m SGX Pharmaceuticals 2003-03-31 active Selected Cloned HI0568 MSKAICHQIAQELNVRPEQVIAAVTLIDDGNTVPFIARYRKEVTGGLDDTQLRNLDSRLAYLREMDDRRQTILKSI QEQGKLTPELEQAILSADSKNRLEDLYLPYKPKRRTKGQIAIEAGLEPLADTLWTQPNTDPESEAAKYINAEKGV ADSKAALDGARAIVMERIAEDANLLEKIRQHLNRNAEIVSRVIEGKEQAGEKFKDYFDHREPISKAPSHRALAML RGRNEGFLTLTLNADPELEESARQSYCETLIAEHYGIHLSQATADAWRKQVISWAWKIKISMHMETELMSAMKER AEIEAIEVFATNLKDLLMAAPAGPRATLGLDPGLRTGCKVAVVDATGKVLATDTIYPHAPQHQYDRAMQSIALLV KKFNVDLIAIGNGTASRETDAFAADLIKRGNLKVQKIMVSEAGASVYSASELAAKEFPNLDVSLRGAVSIARRLQ DPLAELVKIDPKSIGVGQYQHDVSQTLLAKRLDAIVEDCVNAVGVDVNTASAALLTRVAGLSAALAQNIVDYRDE NGRFESRSALKKVPRLGPKAFEQCAGFLRIMDGKNPLDASAVHPEAYPVVKTIAEKNSKDLKALIGNTEFLRTLR AVDYTDENFGVPTVTDIIKELDKPGRDPRPEFKTATFAEGIHEVSDLEVGMVLEGVVSNVANFGAFVDIGVHQDG LVHISALTDRFISDPREVVKAGDIVKVKVMEVDVQRKRIALSMRLNDEPGQDNRSQRSAAPRSGQERRAPRRDEP QGNALGGAMGGAFAAAFAKAKK Vibrio cholerae NYSGXRC-6019n SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0568 MQNSLLTQHIAQIIAAEISSQPTQARAAIALLDEGASVPFIARYRKEATGGLDDTQLRILETRLTYLRELEERRST ILTSITEQGKLNDLLHAEILAADTKSRLEDLYLPYKPKRRTRAQIAREAGLEPLADSLLADPTLIPETVAANFVD PEKGITDIKTALEGARAILIERWGEDAALIGELRQWLANNGVIHARLIDNKEDTGAKYRDYFNHTELLSKIPSHR LLALFRARSEEILHLDLDPGNDADAGHQYCESMVMQAACVADQGRPADTWLMTACRLTWRAKLHMHLMLDLFNQA REKAEAEAITVFSNNLKDLLLAAPAGPRIVLGIDPGIRTGCKIAIVDTTGKLIATETIYPHEPRREWDKSLHTLK TLCTQHHITLIAIGNGTASRETDKLVSDLIKAHPALELQKIVVSESGASVYSASESAAKEFPDLDVSLRGAVSIA RRLQDPLAELVKIDPKAIGVGQYQHDVDQFHLAKALDARVEDCVNAVGVYVNTASAALLSRVSGLSASVAENITR YRDEHGSFKQRQDLLKVPRLGAKTFEQCAGFLRIADGNQPLDASAVHPEAYPVVERIVQTTGKPIKALIGDSHTL RMLKPEQFTDTNFGIPTIRDIIKELEKPGRDPRPEFKAVRFTEGVENIKDLKPGMILEGVVSNVAAFGAFVDIGV HQDGLIHISALADRFVKDPRDIVKAGDIVKVKVLEIDVPRKRIALTCRLHEETPPETPVANRTGNERGRPNPVAK KVKATPTDNALAQAFARARLK Xylella fastidiosa NYSGXRC-6020b SGX Pharmaceuticals 2003-01-30 active Selected HI0570 MSSPRAEQKQQTRHALMSAARHLMESGRGFGSLSLREVTRAAGIVPAGFYRHFSDMDQLGLALVAEVDETFRATLR AVRRNEFELGGLIDASVRIFLDAVGANRSQFLFLAREQYGGSLPIRQAIASLRQRITDDLAADLALLNKMPHLDG AALDVFADLVVKTVFATLPELIDPPAADLPPHLMPAAKITHQLRFIMIGGKHWHGLPG Pseudomonas aeruginosa NYSGXRC-6020d SGX Pharmaceuticals 2003-01-30 active Selected HI0570 LLCLFLTFALTFYWIFIDDTLRLSGRFPLYVKEPASKYVLLRYRSFTILEQSSMFILWYSASSTFGKDSDIVMGVR AQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQ RIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQA EAMVTIVFSAGAEALDVGVEQRRQLEERLVLQLRMISKGAYYWYRREQEKTAIIPGNVKDE Shigella flexneri NYSGXRC-6020g SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0570 MEKKRTRAEELGITRRKILDTARDLFMEKGYRAVSTREIAKIANITQPALYHHFEDKESLYIEVVRELTQNIQVEM HPIMQTNKAKEEQLHDMLIMLIEEHPTNILLMIHDILNEMKPENQFLLYKLWQKTYLEPFQQFFERLENAGELRN GISAETAARYCLSTISPLFSGKGSFAQKQTTTEQIDELINLMMFGICKKEV Listeria monocytogenes NYSGXRC-6020h SGX Pharmaceuticals 2003-06-13 active Selected Cloned Expressed Soluble Purified HI0570 ICEDB: T1037 GENBANK NP_396224 LKNSESHGEADGGLRERKKRETKKRLTEKGIALFLERGFDNTTLDEIASAAGISRRTFFYYFKSKDEILLSLQSGI GEMLADAVRRAPSSSTPIEVVRDAAIGVCKVIPTNDMIEMDRLMRTSPSVQARKQVSYVQQEGEIYEALSERWPE PERSTALRVVAMLSVGAMRIAGDIFSQEKGVRPMVDLLEEAFGSLIQEVRSGDPRV Agrobacterium tumefaciens NYSGXRC-6020i SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0570 MRSSRKQTSDTAEAPPRKRVRLSPEVRRQQILDAALVEFSTLGFTAASIAKIARRAGTSKANLYVHFSNKDEIFET LLRDLLVPSRALLQQARQGQNLDELIDAFIDEAYAGLTPQVIAVIRLLIAESHRVPHLIQRWHEETVVPARAEQQ RRIEQYVAAGQMPQTPVTDYFSFVMAPVLYVAVCRMVFRQDVAESEYRNIRETHRKVLHLLLKPQPEGPARAAGG TRSRKPG Ralstonia solanacearum NYSGXRC-6020j SGX Pharmaceuticals 2003-01-30 active Selected HI0570 MRYKSEETYRAILQAAIDVMKDKGFEKASIGEIAKRAGVAHGTFYTYFQAKNEIIPAIADEILQDQLHQLQNRIQE DDDVQTLIRELIDVSFTLTKSYKEVILLCYAGLSYYDSLNRWEEIYDPYYRWIEKHLKKHLTINIQTLVPMIVNL IEFTAERHYFANECEQELSQLKEDTFQVVMNMLR Bacillus halodurans NYSGXRC-6020l SGX Pharmaceuticals 2003-01-30 active Selected HI0570 VHVVPVASSRPLRARSALEKTRRRDDILRSAERLWLSTPYADLSMNQVAREAKLAKGTLYLYFDTKEELFLALLHE YLQGWFQRFGELLGAQRPQTPREMAATLTDALHDQGHLRRLLLLLTTVLRSHLAPEVEANFRRETQQLLKQAVSA MPYAPEINQQILVHCYALAVGWQQMAPTFGQAPHPEYQFVEGEAAFQLALEAVIERLAPRLD Deinococcus radiodurans NYSGXRC-6021a SGX Pharmaceuticals 2003-06-13 active Selected Cloned Expressed Soluble Purified HI0575 ICEDB: T1053 GENBANK NP_438732.1 MTLNDKYPFTDEDQAIINSYKAVVDGVSALIGEHCEIVLHSLENIEHSAICIANGHNTNRQVGSPITDLALRSLRN MQSESVSKPYFTRAKGSVLMKSVTIAIRNKTQRIIGLLCININLDVPVSQFLQCFMLTEHTNETSSVNFANSVED LVAQTIEKTIEEVNADRAVANNTKNRQIVLSLYEKGIFDIKDAINLVAERLDISRHTVYLYIRQIKQEQE Haemophilus influenzae NYSGXRC-6021b SGX Pharmaceuticals 2003-04-01 active Selected Cloned HI0575 VFFFMSRSLLTNETSELDLLDQRPFDQTDFDILKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGR KIGSPITDLALRMLHDMTGADSSVSKCYFTRAKSGVLMKSLTIAIRNREQRVIGLLCINMNLDVPFSQIMSTFVP PETPDVGSSVNFASSVEDLVTQTLEFTIEEVNADRNVSNNAKNRQIVLNLYEKGIFDIKDAINQVADRLNISKHT VYLYIRQFKSGDFQGQDK Escherichia coli NYSGXRC-6021c SGX Pharmaceuticals 2003-06-09 active Selected Cloned Expressed Soluble HI0575 GENBANK NP_813899.1 LESYLRLSEVDKQILHSHALMLDGLGNFFGSTHEVILHSLENLESSAIKVINGHFSNRKEGAPITDMALKMLSQVE SEHDYAVKPYYNKNQKGVILKSSTIPVIGENDRIIGLICINMHLEMPLIDYLQDLLPSGQQNDMSQELKNSEHFS DNIDELITTSLTKVKQAVESDPNVSHLNQNKEIVIRLYDQGIFNLKDSVIKIADRLGISKNTIYLHIRNHKKEEA Enterococcus faecalis NYSGXRC-6022c SGX Pharmaceuticals 2003-06-10 active Selected Cloned Expressed Soluble Purified HI0576 ICEDB: T1058 GENBANK NP_247745.1 VIRMIRKFKVKGLRSPSLLIDMILNDTEEGILVVETDGEEQIKDIEKLLKKYNLKYEVDGNVVKIYVGEIKADKTI NVVGATCPGPIMMVSDMLSKMKNGEILEIICGKNSLTDLTEGLKGMGNEIIKVEDKGDGTYRILVKKGEKKEEKA AVTKIDELFIINTTGTGNAEKAYATFMMADVALKMNLKPTIFLMMDGASLALKGECDRVKHPAFPKLGDLVRDIL SKGVKIYVCELSAEFRGINEKNLEEGFEIAGAPTFLNYLSKPNVRPVWL Methanococcus jannaschii NYSGXRC-6022e SGX Pharmaceuticals 2003-06-17 active Selected Cloned Expressed Soluble Purified HI0576 ICEDB: T1061 GENBANK NP_709119.1 MRFAIVVTGPAYGTQQASSAFQFAQALIAEGHKLSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALN ICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF Shigella flexneri NYSGXRC-6022g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0576 MNIGILLKEGPYNHQAADTAYKFAEAAIAKGHKVDAIFLYNDGVINATKLGDPPQDDRNIAARWTELNQKHGVEVL ACIAASKRRGINDDVMIDGAEITGLGTLTDIAIRNDRLLTFGD Chlorobium tepidum NYSGXRC-6023a SGX Pharmaceuticals 2003-01-30 active Selected HI0677 MKLFKAEQWNIEVLLPLFEAYRQAYGQAENPERTLAFLTNRMRFNESLFFIAVDENEKAIGFVQLFPRLSSLQLQR YWQITDIFVLEHAQQTEIYAALISKAKDFVHFTQSNRLVAELAQNQYSMLESEGFKLNPKERLFELSLSC Haemophilus influenzae NYSGXRC-6024a SGX Pharmaceuticals 2003-04-01 active Selected Cloned Expressed Soluble HI0698 GENBANK NP_438857.1 MKKKSLKLTALFLALSCFPAFAEQTVDIEVQGIRGFRAVRNTDLNVNLINKEEMDGSERYQHLVTKAVDRGLRVFG YYESSVRFERKQRQGKRDLLIAHVTPGEPTKIAGTDVQIEGEAAQDENFNALRKNLPKDGVLVEHQTYDDYKTAI SRLALNRGYFDGNFKISRLEISPETHQAWWRMLFDSGVRYHYGNITFSHSQIRDDYLNNILNIKSGDPYLMNNLS DLTSDFPSSNWFSSVLVQPNVNHKSKTVDVEIILYPRKKNAMELGVGFSTDGGVHGQIGWTKPWINSRGHSLRSN LYLSAPKQTLEATYRMPLLKNPLNYYYDFAVGWEGEKENDTNTRVLTLSALRYWNNAHGWQYFGGLRMRYDSFTQ ADITDKTLLLYPTVGFTRTRLRGGSFATWGDVQKITFDLSKRIWLSESSFIKVQASSAWVRTYAENHRVVARAEI GYLHTKGIEKIPPTLRFFAGGDRSVRGYGYKKIAPKNRNGKLVGGSRLLTTSLEYQYQVYPNWWAATFADSGLAA DNYTAKELRYGTGVGVRWASPVGAIKFDIATPIRDKDNSKNIQFYIGLGTEI Haemophilus influenzae NYSGXRC-6024b SGX Pharmaceuticals 2003-04-01 active Selected Cloned Expressed Soluble HI0698 GENBANK NP_418641 VRYIRQLCCVSLLCLSGSAVAANVRLQVEGLSGQLEKNVRAQLSTIESDEVTPDRRFRARVDDAIREGLKALGYYQ PTIEFDLRPPPKKGRQVLIAKVTPGVPVLIGGTDVVLRGGARTDKDYLKLLDTRPAIGTVLNQGDYENFKKSLTS IALRKGYFDSEFTKAQLGIALGLHKAFWDIDYNSGERYRFGHVTFEGSQIRDEYLQNLVPFKEGDEYESKDLAEL NRRLSATGWFNSVVVAPQFDKARETKVLPLTGVVSPRTENTIETGVGYSTDVGPRVKATWKKPWMNSYGHSLTTS TSISAPEQTLDFSYKMPLLKNPLEQYYLVQGGFKRTDLNDTESDSTTLVASRYWDLSSGWQRAINLRWSLDHFTQ GEITNTTMLFYPGVMISRTRSRGGLMPTWGDSQRYSIDYSNTAWGSDVDFSVFQAQNVWIRTLYDRHRFVTRGTL GWIETGDFDKVPPDLRFFAGGDRSIRGYKYKSIAPKYANGDLKGASKLITGSLEYQYNVTGKWWGAVFVDSGEAV SDIRRSDFKTGTGVGVRWESPVGPIKLDFAVPVADKDEHGLQFYIGLGPEL Escherichia coli NYSGXRC-6024c SGX Pharmaceuticals 2003-04-01 active Selected Cloned Expressed Soluble HI0698 GENBANK NP_251233.1 MRLTQGLFRFPLAGLLCLSTAAFAESQLSVRVTPANAALKANIEAYVGSLGERDEAALQRFRRNAEAQAEKAAQAL GYFQAQIDSEVKDGKPPKLTLKVVPGEPVRLRQVNIQVLGEAASLESFRLPSGKQLKPGAKLNQGVYEDAKRLIQ NQASRYGFFQGRFSTQRLSIDPRAGIADIDLVYDSGQRYTFGKVSFDGDSIIEEELLRRMVPFKAGQPYDSELIA ELNQNLQSSGYFEGVRVDAAPTQAQADGARQAIPVAVRLEARKPRTMGVGLGFSTDVGARARFNWTRHWVNAEGH SLGFESEISAPRQNVGAWYEIPLDPPLTDKLRFTSGYQFEDLVDTESKLLTLGGEWHSKRPDGWQRVVSLNWMRE EYKLGDDSGLSSFLMPGIGYSLLETDNKVDPSHGYRLQFNVKGAKEGLLADADVLHVDAMAKGLTSFAGGHRLLG RLQVGGIATNDYKSIPPSLRFFAGGDQSVRGYDYRTLSPENSDGDKIGGRYMIAGSVEYQYPLAERWRLATFVDQ GNAFNSLDFPSIKTGVGFGVRWVSPVGPLRLDLAHALDDDGGFRLHFSMGPEL Pseudomonas aeruginosa NYSGXRC-6024d SGX Pharmaceuticals 2003-04-01 active Selected Cloned Expressed Soluble HI0698 GENBANK NP_458846.1 VPHIRQLCWVSLLCLSSSAVAANVRLKVEGLSGELEKNVRAQLSTIQSDEVTPDRRFRARVDDAIREGLKALGYYE PTIKFDLLPPPAKGRQVLIARVTPGQPVLIGGTEVILRGGARTDKDYLALLKTRPAIGTVLNQGDYDNFKKSLTS VSLRKGYFDSEFIKSQLGIALGRHQAFWDIDYDSGERYRFGPVTFEGSQIRDEYLQNLLPFKEGDEYESKDLAEL NRRLSATGWFNSVVVAPEFEKSRKTKILPLKGVVSPRTENTIETGVGYSTDVGPRVKASWKKPWMNSYGHSLTTS TSISAPEQVLDFSYKMPLLKNPLEQYYLVQGGFKRTDLNDTEQDSTTLAVSRYWDLSSGWQRAINLRWSFDHFTQ GNVTNTTMLFYPGVMISRTRSRGGLMPTWGDSQRYSVDYSNTAWGSDVDFSVLQAQNVWIRTLYDRHRFVMRANL GWIETGDFDKVPPDLRFFAGGDRSIRGYKYKSISPKDSDGNLKGASKLATGSLEYQYNVTGKWWGAVFVDSGEAV SDIRRSDFKTGTGVGVRWASPVGPVKLDFAVPVGDKDEHGLQFYIGLGPEL Salmonella typhi NYSGXRC-6024e SGX Pharmaceuticals 2003-01-30 active Selected HI0698 MSPLYNESKSSMRRKSLPALISLWLFSAVSYADVKLEITGISGAEKDNVEAYLSSIAAQDYSTSLRFQSQLERSMT EALNALGYYHPSIDFTVSEDNQRLRAAVTLGEVTRLSEVDIVIRGEAEGDRDFQRLIRRSGLRVDAPLNHSLYDN LKSGIRNLALQKGYFNGDFQASRLEVIPELNQARVILHFDSGIRYLFGATTVEGSQIDENRVMSLRPFKQGEPYL VSQVGEFNQNLSNTDWFSSVFVEPDLSQLDEGRELPIKVTLAPQARNQLETGLGYSTDVGVRGSLKWKKPWVNSQ GHSFDSSFSLSIPEQTITAGYKIPLEDALNEYYRIQYGMKHLDKRDTESLESNLSLERHWQLDGGWHRTVFIRYL LENYRQGLQDDNSQFLLPGMTYTRTRTRSNSGLLTWGDKQTITLEYGDPALLSETRVLRLQTGSSWLRTYARNHR ALVRVDGGANLVDEFDQLSPSLRFFAGGDNNLRGYGYKSISPQDASGALTGAKYIATSSIEYQYRLTGNWWAAMF MDVGDAFNDNPEWKKGVGTGIRWISPVGPIRLDFAWGLDAAPGDEFKIHFTLGPEL Vibrio cholerae NYSGXRC-6024f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0698 LKSLRCFWNVRFITLSMLPRYTAQMLRRFIPPMLSLWLLFASLAQANGTVDKIQIKGLDKGDDVEMMKNITVSLSL YSVVGKEQGEFRLEYLLSQAEFQTRQALEPFGYYAPTIRIDAPRQNDHITVVIYVDKGEPVRVRQAHVAMTGAAA QDHYLQRDLEDFKPKLGEIFNHPTYEASKVRITRRLAERGYFDADFTHRRVEVTRAAHAADIDLIWESGRRYDMG PVRFHYDYFHEGLFNPLVYWDEGSYFHEGKLDRLRESLTKLDYFSSIDIQPKPEEADPEGNVPVDVKLERAKSKI YTAGISYGSESGAGLRAGVERRYMNARGHKMNARLDYAQNLKSLTTAYQIPAFKWLDGWYIFFARAYDEQTKYID LRNVKLSAARSGQINRHLTATASLNALRGRWRYRADDGTNTVAYQQSTLVYPQLEASYVDVDDATFPRNGSAATV LLRGGASALGSKSNFTQLHGQLRWFHGLGASSRLILRGEAGTTWASDLVAMPPSLRFFAGGVNSIRGYAFREVGP RTAKPDAFALGAKHVFSAGAEFEYYYKGGPFGGAVFVDSGSAFNRYPDWHTGVGIGLRYRSPVGPVRVDIARGLN SPDSKIQLYIDIGANL Xylella fastidiosa NYSGXRC-6024g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0698 MALKPLTLAAALLSVATAHAQVLPPAPPGPVLEDPAQRAQRERQDTERRREATQPAPQIAVAPSVPDDAAVDAVAE PGTTFDIHRIELTGNTVLDAETVERVTQPFVNRALGTNRINLLLRRLTEAFVARGFVTTRAYLAPQNLKVGVLTI AVVPGKVEALQINGKTVRTTVPDAKLAEGPQAGGWLTDAGTVWSMPAVGDTLRLSDLEQGVDQINRLRRNQAEVQ ILPGQAPGGSVIALANQPGDRFRFSAGTDNYGSRATGTTRLRAGIDADNALGLQEAVSLSYIGTRDTNAAIVSAA VPFGYNTFSYTGSLSEYNSLIGDTALLYGRTFAHAFGWNRVIERDPGGRTAFDVTLTHRRSEREVNNLLFEPQSL SVLRVAVNGLRKFAVGNQGGYATWEAGLSRGMDALNASHDAPDITRDEAHSQFWKLDGNASTQLPLPAIGRAALA YRGQVLAQWSNVALFGSEQIFAGGMGSVRGFREGLISGDRGLTLRNEVVWGNVPVLAGVRIEPYVFLDGGQTQLV ANQHWQYLAGTGMGVRLAANAGKHAFTSELLLGRALVQPAELGSKATVLLATMNYSF Ralstonia solanacearum NYSGXRC-6025a SGX Pharmaceuticals 2003-06-19 active Selected Cloned Expressed Soluble Purified HI0767 ICEDB: T1075 GENBANK NP_438926.1 MKKIQTPNAKGEVRIIAGLWRGRKLPVLNSEGLRPTGDRVKETLFNWLMPYIHQSECLDGFAGSGSLGFEALSRQA KKVTFLELDKTVANQLKKNLQTLKCSSEQAEVINQSSLDFLKQPQNQPHFDVVFLDPPFHFNLAEQAISLLCENN WLKPNALIYVETEKDKPLITPENWTLLKEKTTGIVSYRLYQN Haemophilus influenzae NYSGXRC-6025c SGX Pharmaceuticals 2003-01-30 active Selected HI0767 MKIVSGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEGGRVLDLYAGSGGLSIEAVSRGMSSAVLVERDRKA QTIVAENIQMTKEVGKFQLLKMDAERALEQVSGEFDLVFLDPPYAKEQIVADIEKMAKRELFSEDVMVVCETDKA VELPEEIACLGIWKEKIYGISKVTVYVR Streptococcus pneumoniae NYSGXRC-6025d SGX Pharmaceuticals 2003-04-29 active Selected Cloned HI0767 MRVISGEYGGRRLKALDGDNTRPTTDKVKESIFNMIGPYFDGGMALDLYSGSGGLAIEAVSRGMDKSICIEKNFAA LKVIKENIAITKEPEKFEVRKMDANRALEQFYEEKLQFDLVLLDPPYAKQEIVSQLEKMLERQLLTNEAVIVCET DKTVKLPETIGTLKKTRETVYGITQVTIYRQEA Enterococcus faecalis NYSGXRC-6025e SGX Pharmaceuticals 2003-01-30 active Selected HI0767 MRVIAGKHKSKALESMEGRNTRPTMDKVKEGIFNSLYDVSGIGLDLFAGSGALGIEALSRGMDKVIFVDQNFKAVK VIKSNLANLDLEAQSEVYKNNADRALKALSKRDIQFDVIFLDPPYNKGLIDKALKLISEFNLLKENGIIVCEFSN HEEIDYQPFNMIKRYHYGLTDTLLLEKGE Staphylococcus aureus NYSGXRC-6025f SGX Pharmaceuticals 2003-01-30 active Selected HI0767 MGETRITGGKYRGRKLKTGNFFRPTMSSVRSALFNMIDIEGKSFLELFCGSCVVSCEALSRGAERVVCVDRSKRAL SICRKNLESLNETATIIHSNVVDFLQNTGEKFDVVFLDPPYNDVEIINKTLSLLPKVMKEDSLAVLEKSKRIELD FSNFEVVKRKDYGETELVFLKVKR Thermotoga maritima NYSGXRC-6025i SGX Pharmaceuticals 2003-01-30 active Selected HI0767 MKKPNHSGSGQIRIIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNWLAPVIVDAQCLDCFAGSGALGLEALSRYAA GATLIEMDRVVSQQLIKNLATLKAGNARVVNSNAMSFLAQKGTPHNIVFVDPPFRRGLLEETINLLEDNGWLADE ALIYVESEVENGLPTVPANWSLHREKVAGQVAYRLYQHEAQGESDAD Shigella flexneri NYSGXRC-6025j SGX Pharmaceuticals 2003-06-27 active Selected Cloned Expressed Soluble Purified HI0767 ICEDB: T1086 GENBANK NP_229804.1 MQRRRQPNPSQKKAPTGQVRIISGLWRGRKLPVHDAEGLRPTTDRVKETLFNWLAQEVPNARCLDLFAGSGGLGFE CASRQANQVTMLELNPLAFQQLKTNVQSLKAENIELIHTDALAFLRQSGKPYDVVFIDPPFRQGLLQETTQLLEQ NGWLAPQAMIYIECEKELPLTELPPHWHLHREKSAGQVCYRLFIREEQ Vibrio cholerae NYSGXRC-6025k SGX Pharmaceuticals 2003-06-10 active Selected Cloned Expressed Soluble Purified HI0767 ICEDB: T1080, T1081 GENBANK NP_462473.1 MKKPTHSGSGQIRIIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNWLAPVMVDAHCLDCFAGSGALGLEALSRYAA QATLLEMDRAVSQQLQKNLATLKANNARVVNTNTLTFLSQPGTPHHVVFVDPPFRKGLLEETLQLLETQGWLADD ALIYVESEVENGLPPVPANWALYREKVAGQVAYRLYQRDAQGENDVD Salmonella typhimurium NYSGXRC-6025l SGX Pharmaceuticals 2003-01-30 active Selected HI0767 MSLKIYGNRQIKTLPGQETRPTTGRVREAVFNIWQGEIEGYRWLDLCAGNGSMGAEALCRGASLVVGIEKSSRACA IIQENWQRIANNEQQWRILRGDVVQQLKNLSGQQFDRIYFDPPYASGLYQPVLEAIAHHQLLDPSGEIAIEHNPQ GWVDILIPDWEICRQKVYGNTALTFYRSEELGA Nostoc sp. NYSGXRC-6025m SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0767 VRVCGEGHVRIIGGRWRNTRLRVPELPGLRPTASRVRETLFNWLMPVLPGAHVLDLFAGSGALGLEAVSRGAARAV LVERHAELVVRLREQVARLGAQDQVEIVQADALQWLQRPAAVRFDIIFLDPPFAAGVWETVVVRLAGHVAVAAWL YMESPVDMEPVMLPGWELHRDDRTREVCYALYRYPAVTLPVGSKSVSSV Xylella fastidiosa NYSGXRC-6025n SGX Pharmaceuticals 2003-10-21 active Selected Cloned Expressed Soluble Purified HI0767 ICEDB: T1073 GENBANK NP_243456.1 MRVIAGEQKGLTLKAVPGHKTRPTTDKVKEAIFNMIGPFFDGGIGLDLYGGSGGLGIEALSRGVERMIFVDQQKRA IETIKQNLSHCGLEGRAEVYRNDAKRALQVLTKRGIVFAYVFLDPPYAKQTIKNDLAILANHGLLEEGGVVVCEH DRDTMLPDQIEYAVKHKEETYGDTMITIYKYEKGGNLE Bacillus halodurans NYSGXRC-6025o SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0767 MRIISGNYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFDGGRVLDLFAGSGGLSIEAISRGMTGAVLVEKNRRA QAVIEANIRMTKEGNKFQLLKMDAARALTNLNEQFDLIFLDPPYAKEEIMKTIEELCQRKLLSEEVMVVCETDKA VELPEEVAELGIWKQKIYGISKVTVYVR Streptococcus mutans NYSGXRC-6026a SGX Pharmaceuticals 2003-03-31 active Selected Cloned Expressed HI0849 GENBANK AAC22506.1 MAHRRKFGGGRGEAVAKAVGIKGSALPTVIDATAGLGRDAFVLAAIGCQVRLVERHPVVFLLLQDGLNRAYQDEEI GEMLQQNLHLLNVQHINELDPNSDYADVVYLDPMYPHKQKSALVKKEMRVFQHLVGADLDADELLLPALQLAKKR VVVKRPDYAEFLCGKQPHFSHETKNHRFDIYMGASQC Haemophilus influenzae NYSGXRC-6026b SGX Pharmaceuticals 2004-06-22 active Selected Cloned Expressed Soluble Purified HI0849 ICEDB: T1092, T1925 GENBANK NP_252370.1 MTDSAAPRLHVQALSADCAEAARRWAERLGLPLAADDEAEFAVQVGEQGLQVLQLGADSPGPVRVDFVEGASAHRR KFGGGSGQMIAKAVGVQPGIRPRVLDATAGLGRDGFVLASLGCEVTLVERQPLIAALLEDGLERARRDPDVAPIA ARMRLLGGNSADLMRAWDGEAPQVVYLDPMFPHRDKSALVKKEMRLFRPLVGDDLDAPALLQAALALASHRVVVK RPRKAPIIEGPKPGYSLEGKSSRYDIYPKKALGKG Pseudomonas aeruginosa NYSGXRC-6026c SGX Pharmaceuticals 2005-05-20 active Selected Cloned Expressed Soluble Purified HI0849 ICEDB: T1089, T1924 GENBANK NP_839391.1 VVVNRSWMRCWSITALRADHSVKICLIDETGAGDGALSVLAARWGLEHDEDNLMALVLTPEHLELRKRDEPKLGGI FVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGL ARGYADAEIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLE PARLLATKRVVVKRPDYAPPLANVATPNAVVTKGHRFDIYAGTPV Shigella flexneri NYSGXRC-6026f SGX Pharmaceuticals 2003-06-10 active Selected Cloned Expressed Soluble Purified HI0849 ICEDB: T1091 GENBANK NP_274614.1 MTDILIDNTATETVRTLIRAFPLVPVSQPPEQGSYLLAEHDTVSLRLVGEKSSVIVDFASGAAQYRRTKGGGELIA KAVNHTAHPTVWDATAGLGRDSFVLASLGLAVTAFEQHPAVACLLSDGIRRALLNPETQNTAAHINLHFGNAAEQ MPALVQTQGKPDIVYLDPMYPERRKSAAVKKEMTYFHRLVGEAQDEAALLHTARQTAKKRVVVKRPRLGEHLAGQ DPAYQYTGKSTRFDVYLPYGTDKG Neisseria meningitidis NYSGXRC-6026g SGX Pharmaceuticals 2004-06-22 active Selected Cloned Expressed Soluble Purified HI0849 ICEDB: T1088, T1923 GENBANK NP_356603.1 MKEQNESFVVDFVGGAVGHRFRSGEGRGQALPKAAGFTKGRTPKIVDATAGLGRDAFLLASLGAEVTLIERSPGMH AHLADGISRALEAGGAYAEAASRMTLLQGDSRQLLKELSPEVVVIDPMHPPRHNTALVKKEMRVLRELVGSDPDQ VELMEVALAHATKRVVLKWPLRADPMPGIRKPSHQIIGKNTRYDVFMIFGNSLDQQE Agrobacterium tumefaciens NYSGXRC-6027b SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0855 MFDSTLNPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGL PIAAALGALGGNANAGLEVLKDATAQAIADAKALLAAGKVSVKIQEPCNEILFSRAKVWNGEKWACVTIVGGHTN IVHIETHDGVVFTQQACVAEGEQESPLSVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGKWGLH IGATLEKQCERGLLAKDLSSSIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARA LMLSHLSAIYIHNQLPRLSALCAATTAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVST SASAAWKAVLMALDDTAVTGNEGIVAHDVEQSIANLCALASHSMQQTDRQIIEIMASKAR Escherichia coli O157:H7 NYSGXRC-6027c SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0855 MFESKINPLWQSFILAVQEEVKPALGCTEPISLALAAAAAAAELNGTVERIDAWVSPNLMKNGMGVTVPGTGMVGL PIAAALGALGGDAKAGLEVLKDASAKAVADAKAMLAAGHVAVMLQEPCNDILFSRAKVYSGDSWACVTIVGDHTN IVRIETDKGVVFTQADNAQEEEKTSPLGVLSHTSLEEILAFVNAVPFDAIRFILDAARLNGALSQEGLRGSWGLH IGSTLAKQCDRGLLAKDLSTAILIRTSAASDARMGGATLPAMSNSGSGNQGITATVPVMVVAEHVGADDERLARA LMLSHLSAIYIHHQLPRLSALCAATTAAMGAAAGMAWLIDGRYDTIAMAISSMIGDVSGMICDGASNSCAMKVST SASAAWKAVLMALDDTAVTGNEGIVAHNVEQSISNLCSLACRSMQQTDKQIIEIMASKAH Salmonella typhimurium NYSGXRC-6027d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0855 MDTSTQQRIISLIKKEVVPATGCTEPVAVALAAAQAASLMEQRPDHVEVLLSPNILKNAMGVGIPGTGMIGLPIAI ALGIVVADPTKQLKVLDGIAPEQLEEAKKIVDGKIIQVAVKQGDIDKLYIEINMSAGSESASTIIEKIHTNIIYA AHNGQVVIDGRHDAADKSESASSESEEEIALSFEMVYDFAMNTPTEEIEFILEAARLNRHASEVSMKGNYGHAVG RMIQGSLGRRYLGDSSLTRMLTYTSSACDARMDGAPVTVMSNSGSGNQGITATLPVLSFAEDEQADHERTVRALV LSNLMVIYIKQKLGRLSALCGCVVAATGSSCGLCYLMGGTKEQIGFAIKNMIGNITGMLCDGAKPSCSMKVSSGV SSAMFSALLAMEKKVVTSNEGIVDDDVDQSIDNLTSIGRDGMNATDTLVLNIMTSKK Porphyromonas gingivalis NYSGXRC-6028a SGX Pharmaceuticals 2003-01-30 active Selected HI0858 MNTQKRQQIRTEIRKIRANLTALQQHQAEQSVTQHALNLIEQRQAKNIALYFSFDGEISTKALIQSLWMQNKNVYL PVLHPFTKHYLLFLRYLPDTPMKQNQFGIWEPKLNVQNVLPLNELDILFTPLVAFDKKGNRLGMGGGFYDRTLQN WQNKSFIPVGLAYQCQQVENLPTEHWDVPLFDILVG Haemophilus influenzae NYSGXRC-6028b SGX Pharmaceuticals 2003-01-30 active Selected HI0858 MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTIAVTISRGLEIPTRPVIEQAWEEGKQVCIPKCH PDTKKMQFRTYQTDDQLETVYAGLLEPVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKT VSLLLECQLFAHVPRLPHDIPVHKLITEDRIISCFS Bacillus subtilis NYSGXRC-6028d SGX Pharmaceuticals 2003-06-06 active Selected Cloned Expressed Soluble Purified HI0858 ICEDB: T1110 GENBANK ZP_01827834 LSMKSELRKQVLHEMKAISQEQKQAIDQALTERLLHHPFYQEAKVIATYLSFSHEFQTRELIEQALKDGKKVLIPK TYPKGRMEFVAYDPQQLVKTSFALLEPQGDVEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTL STIYPCQIQDFIPENHDIPVQEVLIDEGNL Streptococcus pneumoniae NYSGXRC-6028e SGX Pharmaceuticals 2003-04-01 active Selected Cloned Expressed Soluble HI0858 GENBANK NP_816417.1 LRKVGLTALEWLKQHPEIKQHKESSLYEQLFASQQWQQAQTIGMIRSLPLELSTQPIFERAMQESKQVAVPRTFKG GKMHFYQVFPETVYDTSAFGVEEPPLTAAEITATAIDLLIVPGIVFNRAGYRIGFGGGFYDRYLEHFSGHSCSLV FSEQLHEQWQPEAFDQPIEQLFIQ Enterococcus faecalis NYSGXRC-6028f SGX Pharmaceuticals 2003-01-30 active Selected HI0858 VTKNEIRKYILHKMKNFNKAEKRKADTWLRNQFFATEEYKEANAIALVLSFNHEVDTFSIIEQALMDHKRIFVPKM DYLNHQMTFKEIFNLKDIDVDNKGIYYPTSKGETTNNLDLIVVPGVGFQDDGYRIGYGGGYYDRFLANYQTKTIS LLYDFQITSFEPESFDQPVDKLIIYQSA Staphylococcus aureus NYSGXRC-6028i SGX Pharmaceuticals 2003-06-09 active Selected Cloned Expressed Soluble HI0858 GENBANK NP_461977.1 MIRQRRRALTPEQQRRFGQQAAARMLSFPPVVMAHTVAVFLSFDGELDTQPLIEQLWRAGKRVYLPVLHPFSPGNL LFLHYYPQSVLVTNRLKIQEPRLDVRDVLPLAKLDVLVTPLVAFDEDGQRLGMGGGFYDRTLQNWQQHKILPVGY AHDCQLVEKLPVKEWDIPLPAVVTPSKIWEW Salmonella typhimurium NYSGXRC-6028j SGX Pharmaceuticals 2003-06-09 active Selected Cloned Expressed Soluble HI0858 GENBANK NP_457459.1 MIRQRRRALTPEQQRRFGQQAAARMLSFPPVVMAHTVAVFLSFDGELDTQPLIEQLWQAGKRVYLPVLHPFSPGNL LFLHYHPQSALVTNRLNIREPRLDVRDVLPLAKLDVLVTPLVAFDEGGQRLGMGGGFYDRTLQNWQQHKILPVGY AHDCQLVEKLPVEEWDIPLPAVVTPSKIWEW Salmonella typhi NYSGXRC-6028k SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0858 LLQTSKPMTDNRSILRQHMRARRHAIHKHARLAAAVTLAEHLLTLPFAPQTGAVAGYWAMDGEIPLHRWQTRLPAQ VRYCLPILAGKTLRFAPWHPGQPLKQNRYGIPEPDVTLDETLTPESMTLVVTPLVGFDTQGHRLGMGGGWYDRSF AFRNRQSPPPWLVGVGFSVQQVSTLPTEAWDICVDAICTELTTLLLPATVST Xylella fastidiosa NYSGXRC-6028m SGX Pharmaceuticals 2003-01-30 active Selected HI0858 MQGDAAEKARLRGERLAARDALTPAERQQKSLSMTAHGVSGIPFAPGTVISGFMPIRSEVDTRPLMEALRARDGRL VLPVVLDQETIVFRVFEADTPLVKTGFGTTGPGEDAEVLDPHILLVPLSVFDGEGQRIGYGAGHYDRAIARLHAK GRQPVLIGIAFDCQEVASVPAEPHDVALHAVLTESGLRWFSAQR Agrobacterium tumefaciens NYSGXRC-6028o SGX Pharmaceuticals 2003-01-30 active Selected HI0858 LRPLDRDDSFHGMTIVDPVAAKTALRVFLRNQRKQLAIETPQADWMIAEQARAPLARLFPDPKGKVAALYHGLGSE ISPLILAEQMAEAGWTLALPKVVNPDGGKMIFRRWTPGQPLKRDKIGLLAPGREQPMIVPDLVVTPLLAFQRDGV RLGQGGGYYDRALAFLRSRRPVFVLGLAYSGQQAENLPHEAHDQRLDAILTEKEYIAVKDMAG Caulobacter crescentus NYSGXRC-6029a SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0868 MNMPLISIIMPVYNAECYLNQGILSCLNQSYQNIELILIDDGSTDKSIEIINNIIDKDKRVKLFFTPTNQGPAAAR NIGLEKAQGDYITFLDSDDFIANDKLEKQLNFMLQNHLVMTHGNYAFCDLEGNQIKLVTTSKKIDYLTLLQGNQF KIMTVLVERESIKLLRFPNIKHEDYAFFLDCLKEVKQSILYSHQASSFVRIGKVSVSSNKFKSAIWTFNIYFKRE KLGVVKSIYYFILYAYNGFIKYKK Haemophilus influenzae NYSGXRC-6029c SGX Pharmaceuticals 2003-01-30 active Selected HI0868 METALVSIIMPMYNAGKFLSKSIESVLEQTYQNWELLLIDDGSKDDSIDIALAFMEKDSRIFLLKNEQNMGIAKTR NKGIEASKGQYIAFLDSDDLWLPNKLEVQVKWMEEKKLLFTCSSYFVCNENGNITHERNFSEGPQTYQDLLKTNT IGCLTVVVESNLLKRHLMPDLKHEDYATWLNILKEINTVYFINEKLAIYRKLTTSTSSNKWNTISWVWKILRQNE QFSVIKSSFYLMRFLFYTTFKYAKNE Enterococcus faecalis NYSGXRC-6029d SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0868 MNKETVSIIMPVYNGAKTIISSVESIIHQSYQDFVLYIIDDCSTDDTFSLINSRYKNNQKIRILRNKTNLGVAESR NYGIEMATGKYISFCDADDLWHEKKLERQIEVLNNECVDVVCSNYYVIDNKRNIVGEVNAPHVINYRKMLMKNYI GNLTGIYNANKLGKFYQKKIGHEDYLMWLEIINKTNGAICIQDNLAYYMRSNNSLSGNKIKAAKWTWSIYREHLH LSFPKTLYYFLLYASNGVMKKITHSLLRRKETKK Escherichia coli O157:H7 NYSGXRC-6029e SGX Pharmaceuticals 2003-01-30 active Selected HI0868 MIEEATSSKHSGTTDAPLVSVVAPCFNAEKYLEEALRSIYEQDYPNFEVIIVDDGSTDNSYAMLEQLQKVHGFQLY RQQNQGVSAALNFGLRHARGDYVATPDLDDIMLPHSLSVRAAYLDQHPEVGCVGALVIYIDSEGQETKRQNGNRI RQLDFDYLLGNAYVCGAPVSLYRMEALRAAGFYDPEIKVQDFQMTLRIASQGYQIHKLPVLVTRYRRHPDNLSRR YKVLLDADLRTIAPYQSHPAYERGRTELVNKALKYAVVADKRHAWQLLRSLPLRQWNRTTFRRLKRFLLHHES Pseudomonas aeruginosa NYSGXRC-6029h SGX Pharmaceuticals 2003-03-27 active Selected Cloned HI0868 MDIFEEIRKKIEQKEFSKAKEMAEKIEDEVEKYNSLGIIHYYEGKVSEALEFFKKALDINPVHDDALFNYSKVLFE KGEYFESWRYLTRINNKTWEVYDMLGDTQLKQNNPAMALYYYKKAAELSNIPEMKEKYQILKDQFKKDVKLAIFC LPGLDNFIKDIAQILSNIYDVKLVVTTDVRQIQEAYNWADIVWLEWANEMAVEVTNKLPKDGKKILCRLHSYEAL ANYPEKINWKNVDKLILVAEHIERILRDYHSEVYKQVKDKIVIVPNGLDLNRLKFKVRQPGFNIAVVAHINHKKD PAMWLQIIGMLRKIDERYTLHIAGDFQEIRYANYFKHFIKDAGLEKNVKLYGWVEDVNAFLEDKNYLLSTSIHES FGYNIAEAMAKGIKPIIHNYAGAKTQWPDDLVFNFIDEVIRIVTSRDYNSEKYRSFVEKNCSLEKQITSILSIVQ LQDNNRTKNKSIHKKSTTDTENSFAKIWKEYSKIDSFTIMNDLPGKSLRSEFVSLLERFFILNKARILEVGTGTG AFSIELALREADVTGIDIDPTSIELAIRISKDYNVENVEFKVGDGFKLTESFKPQEFDIAFNMGVVEHFKDDDII KMLKQMGEVAKFVVVGVPYSGSFVYKTAKETAQKLGAWEYGFERDFLTLEPLIRRAGLIPLHEEVIGVLAEPFYL RRINPEWVPLKIAENLQKYFQGEKVGSWLICFATKWPGYADEFLKLDDHKKIKFESTQISLLTVPKPLVSIVIPV LNGANYVKRLVDNIKRIDYENFEVVLVDDGSTDGTADLFERLIKGEPKLREKILIIRNKENVGTFHSRLIGVKHS QGSFVFFHDIDDLVYSKGVKKLLDDLLNFPNKKTLLTVTNALMSGEQFNGEIWCSNFYKNKEELFVSEITSLSGK FSIIDTLIERIPLQKAYEELAEVLHKVGIIKMTIAEDTILADYLLLEHFVEKMIPTFYTFLGYEVGNLQSSSKKL LERIKQIPIQISFLMVMSQKEKLFDKATLNQLENTVKQSAARIYGQELGQKFFENYLEFKRRFSSILL Thermotoga maritima NYSGXRC-6029i SGX Pharmaceuticals 2003-01-30 active Selected HI0868 MERINVDGPVVSIITPCYNAEMFIRDTIESALNQTFSNWEMVIVDDGSTDRTVQIVESYASQDERIRLIQLEKNSG PAVSRNTAIQHARGRYLAFLDSDDQWLPEKLERQLEFMQKRNVAFSFTSYKTMTEDGSETGKVVNVPENVDYHEL LKQNVIGCLTVMLDQEKTGHVQMVNMRSRQDYALWLHLCKRGFIAYGLQDVLAKYRVVHNSVSHNKWKMAKQNWR LYRENEKLSFVKSGWYFMHYVWRSLKKYLSK Bacillus halodurans NYSGXRC-6029k SGX Pharmaceuticals 2003-01-30 active Selected HI0868 MPSEAFRRHRAYRENKLQPLVSVLICAYNVEKYFAQSLAAVVNQTWRNLDILIVDDGSTDGTLAIAQRFQEQDGRI RILAQPRNSGLIPSLNIGLDELAKSGGGGEYIARTDADDIAAPDWIEKIVGEMEKDRSIIAMGAWLEVLSEEKDG NRLARHHEHGKIWKKPTRHEDIADFFPFGNPIHNNTMIMRRSVIDGGLRYNTERDWAEDYQFWYDVSKLGRLAYY PEALVKYRLHANQVSSKYSIRQHEIAQGIQKTARNDFLQSMGFKTRFDSLEYRQIKAVAYELLEKHLPEEDFERA RRFLYQCFKRTDTLPAGAWLDFAADGRMRRLFTLRQYFGILHRLLKNR Neisseria meningitidis NYSGXRC-6029l SGX Pharmaceuticals 2003-01-30 active Selected HI0868 MKVYPKVSIVMPVYNSERYLAEAIESILDQTYNDFEFIIVDDGSTDESYNIISSYANKDNRIIVISREHRGLVDSL NEGINIARGKYIARMDADDISINNRIEKQFEFLELNKDVDILGTRIEAFGDIDEKQKTIYNSAFSIKFDSQNIEQ VFLTSCAIPHPSVMFKKDSIVKLRGYRKEYDTAEDYDLWLRAIRNGYKIVRMDECLIKYRVHNKSKTAVEMFNPK MVEYTMKAKIDYINDTNKKDKVDYLIWGASTGGKLVKKVVESTTDKFNLIGFIDKYKEGEVDECRIYKPEDLMKL HSDYVFIATLPGKEEADEFLKNCGLKKFKEYISLV Clostridium acetobutylicum NYSGXRC-6029m SGX Pharmaceuticals 2003-01-30 active Selected HI0868 VRMLGPPLMELKSLVSVSIVIPVRNGERYIVEAIESVLLQGETIREVLVVDDGSTDATAQKVEGFSDPRVKLLARP QGRQGVSAVRNFGLSQARGEWTMFLDADDRLKPGAITALCAGISGPDVVAVYGDYERIDENGTKIGRRNLIRRRE KPDGFILQSLLGGNFIVNGGIMLVRTRIFQDFGGFDETLRYAEDWYGWCRLAAAGRFVYLPGCHVLDYRVHRTSV MMNRLLTFRDCEPAIEAVFSDPAIVAAISPQELRRLRHRSENHMNAYTVAQAFRARRYREAFSALADTILNRPRQ SLRAVVFSAAALAGI Agrobacterium tumefaciens NYSGXRC-6029n SGX Pharmaceuticals 2003-01-30 active Selected HI0868 LEDIVHKYKVSVIICFFNSAETLDAMIKDAVNQTLKDKEIILIDDGSYDGSLEIAEKYANKYSFIKIFSQKNMGLS ASRDKGLSEAQGEYVIYWDGDDSVESTMLEVLYNRAKADNSDIVCSQFYIYFLAINVKRKSLLPFPNYPLTGKEA FKNLLFTVYATFGRKNFVVGTLWDKLIRRELILKNNIRQQNVVFEDIVFVMQIFLKASKVSFVNNYFYTNFQRMG SMSSSISVLHKSKLSLNTMETLLKREGIFNECQNLYKKFFLQFYYFISFKQIYIISWNISDKLVYRAYKEKLISV LDEIKGLSEFQDCYEYAKSFGFNEIQILPRIMLKIWNFSSRLYVNFSIFIYKFFIKN Borrelia burgdorferi NYSGXRC-6029o SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI0868 MIIPMNNKHPLPTPLVSIIIPVYNVEKYLYRCVKSILSQDYYDYEIILVDDGSTDGSGMICDELTEQHGHISVIHK PNGGQGSARNAGLNHAKGKYIWFIDSDDYISPHSLSVIMSQITQGDFDALFFPYIKSNGNILIGEAVGKYHAGVY RGQQLLLEGLVNMSMCTIVSLRSRWIDNRIFFREDIHFEDFEINPRVLKFLERAIFLDSNIIPYIYYTRLGSTMN QLDPQKRMRQTEDFLRIEKSWKEWFNLDSPEPNSYDMLMLRTGTNMLHRNLLNFVRNSNFSISTKLKLYAQYRKK GVFSWFYNGYRRDPYVGCTSVRVFWNTIGRSYILFSLFSIVEEIWKKIRK Porphyromonas gingivalis NYSGXRC-6030a SGX Pharmaceuticals 2003-01-30 active Selected HI0922 VKYLHFTRPTIKVIFMINSIKTLLLIATLAILSACGWHFQQSVTMPSEWRTLALESDDSYNDFTVIMRRKLQENQV NVVNLEQNIPILRINKQITSDQVASIFKHGREAEKLLMLEVEATFRLANGESYPINAKVNRTFFDNARAALAKSE EREVIWNDMREQVARQLIVKIIALQNQIKRK Haemophilus influenzae NYSGXRC-6030b SGX Pharmaceuticals 2003-01-30 active Selected HI0922 VRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLR LGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRA AEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN Escherichia coli NYSGXRC-6030c SGX Pharmaceuticals 2003-01-30 active Selected HI0922 VRYLVTLLLSLAVLVTAGCGWHLRSTTQVPASMKTMILDSGDPNGPLSRAVRNQLRLNNVNLLDKDTTRKDVPSLR LGTVTISQDTASVFQDGQTAEYQMVMTVNASVLIPGHDIYPISTKVYRSFFDNPQMALAKDNEQAMIVQEMYDKA AEQLIRKLASVRAADIQATKEEATADNETAAPASTPARVSTTLSN Salmonella typhi NYSGXRC-6030d SGX Pharmaceuticals 2003-01-30 active Selected HI0922 LPNNETEASMRNTLFPTLKWSLLVLMTSLLTACGFHLRGDYDIPQELSRMSLTSYDQYSTFTRMVHRQLRLNKIDL QAPAEDLPNLHLLSESTGERTLSLYQNTRAAEIELTFVASYRVTVPELGSRTFTTSVTRSYLDNPLTALAKSVER DMIEDEMRKLAASQIVRQMARLKADFARKTLDDESIEGKGITDYRVDTQEVANPVSTEGSSE Vibrio cholerae NYSGXRC-6031c SGX Pharmaceuticals 2003-01-30 active Selected HI0933 VASTDVLIVGAGAAGLMCAMTAAGRGRRVRVLDHANKAGKKILMSGGGRCNFTNLYTEPANFLSRNPHFCKSALAR YTQWDFIGLVAKHQVPYHEKKLGQLFCDNKSSDILEMLLRECAEAGAEILLDTSIEEIARDDAGYRLRTSAGEMR CESLVIASGGLSIPTLGASGFGYQVARQFGHEVLPTRAGLVPFTITDQLKELCAELSGTSVDCRVSCNGQAFREN LLFTHRGLSGPAMLQISSYWQPGDTLEIDLLPDHDASEWLAQQQRERPNSELKTLLAELFTKKLAGLLADRWFVS KPMKQYTPTELAGIAGQLSAWRVTPSGTEGYRTAEVTLGGVSTDEVSSKTMESQRSPGLYFVGEVLDVSGHLGGF NFQWAWASGYAAGQYA Pseudomonas aeruginosa NYSGXRC-6031d SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified HI0933 ICEDB: T1144 GENBANK NP_358245.1 LWYNRAMKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTNNGSLDNLLAGIPGNGR FLYSVFSQFDNHDIINFFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFV LKSADQTFTCEKLIVTTGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFPHKALQGISLDDVTLSYGK HVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKSLKNALKTLLPERLAEFFVQ GYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHT GGFNITSALCTGWVAGSLHYD Streptococcus pneumoniae NYSGXRC-6031e SGX Pharmaceuticals 2003-06-06 active Selected Cloned Expressed Soluble HI0933 GENBANK NP_815135.1 MKKFDVIIVGAGTSGMMATIAAAEAGAQVLLIEKNRRVGKKLLMTGGGRCNVTNNRPAEEIISFIPGNGKFLYSAF SQFDNYDIMNFFESNGIHLKEEDHGRMFPVTDKSKSIVDALFNRINELGVTVFTKTQVTKLLRKDDQIIGVETEL EKIYAPCVVLTTGGRTYPSTGATGDGYKLAKKMGHTISPLYPTESPIISEEPFILDKTLQGLSLQDVNLTVLNQK GKPLVNHQMDMLFTHFGISGPAALRCSSFINQELTRNGNQPVTVALDVFPTKSFEEVPAKQLTEKQRLSFVELLK DFQFTVTKTLPLEKSFVTGGGISLKEVTPKTMESKLVNGLFFAGELLDINGYTGGYNVTAAFVTGHVAGSHAAEI AEYTYLPIEEV Enterococcus faecalis NYSGXRC-6031f SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI0933 GENBANK NP_390884.1 MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAVIIAVGGKSVPHTGSTGDG YEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRDVAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRC SQFVVKELKKQPQVPIRIDLYPDINEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSE LPKDPFRQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIHGYTGGYNITSA LVTGRLAGLNAGQYARS Bacillus subtilis NYSGXRC-6031g SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI0933 IAIECPVTNLEEAYMYQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKN IPGNGKFLYSPFSIFDNESIIDFFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEV NTDQTFTVHTQNNSYESHSLVIATGGTSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKSNRLKGLS LKDVELSVLKKNGKKRISHQMDMLFTHFGISGPAALRCSQFVYKEQKNQKTQHISMAIDAFPELNHEQLKQHITS LIKSTIERLSKYV Staphylococcus aureus NYSGXRC-6031h SGX Pharmaceuticals 2003-01-30 active Selected HI0933 VERFDAVIIGAGAAGMFCAAQAGQAGSRVLLIDNGKKPGRKILMSGGGRCNFTNLYVEPAAYLSQNPHFCKSALAR YTQWDFIDLVGRYGIAWHEKTLGQLFCDDSAQRIVDMLVAECDKGGVTMRLRSEVLSVERDESGFVLALNGETVT TQKLVIASGGLSMPGLGASPFGYKIAEQFGLKVLPTRAGLVPFTLHKPLLEQLQTLSGVSVPCVITARNGTVFRE NLLFTHRGLSGPAVLQISSYWQPGELVSINLLPDLSLEDVLNEQRNAHPNQSLKNTLAMHLPKRLVECLQQLGLI PDVSLRQLNVRDQQTLVDTLTAWQVQPNGTEGYRTAEVTLGGVDTNELSSRTMEARRVPGLYFIGEVMDVTGWLG GYNFQWAWSSAWACAQDLIALKIN Salmonella typhi NYSGXRC-6031i SGX Pharmaceuticals 2004-11-11 active Selected HI0933 VAVMSKTVDVVIIGAGAAGLMCAAQAARRGRQVLLLDHAKKPGRKILISGGGRCNFTNYDVSAANYLCQNPHFVKS ALSQYTNWDFISLVSKYGIAFEERDHGQLFCLDSAKEIVDMLLSECDQPNIEQRYQVEISAIAHTEQGFTLQTTI GEIECASLVVATGGLSMPKLGATPFGYKIAEQFGLPVISTSAGLVPFTLHVQDKEDFAPLSGVAIPVEMRAECGK TFKEALLFTHRGLSGPAVLQISSYWTPGQTITTNLVPDVDLAELLSSEKEAHPNQSLKNTLSKVLPKRLVEVLIE RQLFADKPLKQYSPKELDAVQTRLEQWSIVPNGTEGYRTAEVTLGGVDTDCLSSKTMECKTVKGLFFIGEVMDVT GWLGGYNFQWAWSSGYVAGQWV Vibrio cholerae NYSGXRC-6031k SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI0933 GENBANK NP_269859.1 MTQYDTIIIGGGPAGMMAAISSSYYGYKTLLIEKNRRLGKKLAGTGGGRCNVTNSGNLDVLMAGIPGNGRFLYSVF SQFDNHDIIAFFEENGVKLKEEDHGRMFPTTDKSRTIIDALEKKIKALGGQVLTSTEVVSVKKQDDLFYLKSADQ TFTCQKLIVTTGGKSYPSTGSTGFGHDIARHFKLTVTDLEAAESPLLTDFPHKVLQGISLDDVTLSYDKHVITHD LLFTHFGLSGPAALRLSSFVKGGEIAELDFLPHLSTDDLTAYLSDQRDKNIKNALKGLLPERVADFLSEDYPEKV KQLSPKQEKELLDKLKHLQIPITGKMSLAKSFVTKGGVDLKEINPKTLESKKVPGLYFAGEVLDINAHTGGFNIT SALCSGWIAGKSS Streptococcus pyogenes NYSGXRC-6031l SGX Pharmaceuticals 2003-01-30 active Selected HI0933 LTIGEGESAIDKRRHLEKRKGNGSDGMMTEKCDVLILGAGAAGMMGAIRAGKRGRSVIILDHARAPGEKIRISGGG RCNFTNIHAGPKNYLSSNPHFAKSALARYTPHDFIALVEKHRIAWHEKTLGQLFCDDSAKDIIRMLLAEMQAVNA KLRLETSVSAVTHDGGRFRVTTSGGVIEAESLVVATGGKSIPKMGATGFAYQIAEQFGLKLIEPRPGLVPLTLDP AALEKLSPLAGVAVPAEVSHGKTSFEEALLFTHRGLSGPSILQISSYWREGDAIRLKLEPARDIVSLLRQAKQKN GRQSAQTALSEILPKRLAQHVVEQTGITGNLADMSEKVLAKLAAQVQDWQIKPAGSEGYRTAEVTLGGVDTTGLD SRSMAAKSVPGLYFIGECVDVTGWLGGYNFQWAWASGQAAGEFA Agrobacterium tumefaciens NYSGXRC-6031m SGX Pharmaceuticals 2004-11-13 active Selected Cloned Expressed Soluble Purified HI0933 ICEDB: T1139 GENBANK NP_465442.1 MDYDVIVIGGGPSGLMAAISAAEKNKRVLLIEKGPKLGRKLIMSGGGRCNVTNRRPAEEIIKHIPGNGRFLYSAFH AFDNEDIIRFFERLGVALKEEDHGRMFPVSNSARSVAEAMIQRMEKLGVKIYMQTAVKQVDYEDGHVKGVTLKDG QEISASAVIVAVGGKSVPRTGSTGDGYAWAKKAGHTITELYPTEVPITSSEPFIKQKVLQGTSLRDVSLSVLNAK GKPIITHQMDMIFTHFGVSGPAALRCSMFVLRELKKTGAGTVKMRLDLFPNVSAAELSKDVYKLLEENPKKALKN SLSSLLQEKMLLFLLEKADLEETAEYKQVSPKKIEQFIQLLKDFTFEVNGTLDFEKAFVTGGGVSVKEIKPKEMQ SKLMEGLFFCGEILDINGYTGGYNITCALVTGHTAGAYAAEVSNA Listeria monocytogenes NYSGXRC-6031n SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI0933 MHEVIVIGGGPAGLMASVSAAEHGARVLLLDKGDKLGRKLAISGGGRCNVTNRMPLDELIAHIPGNGRFMYSPFSV FNNEDIIRFFERLGIALKEEDRGRMFPVSDKATTVVQTLLKRINDLGVTVRTNTAVASLEYDDGRIAMVQLKNGE RLKTKTVIVATGGQSVPHTGSTGDAYPWAKAAGHTITELYPTEVPITSAEPFIQEKKLQGLSLRDIELSVYAPNG KQIKTHDGDMIFTHFGLSGPAALRCSQYVVKALKKYKQPTIEMRIDLRPTIPAEALFQETIQNIKAEPKKALKTV LRGIAPERFLQYIYERLRIDSNLPCASVRHEVIREIVQQLKSFSFHVNGTLSIEKAFVTGGGVSVKEIEPKTMHS KKKAGLFFCGEVLDIHGYTGGYNITCAFSTGYTAGKGAAEYVHHKS Bacillus halodurans NYSGXRC-6031o SGX Pharmaceuticals 2004-11-11 active Selected HI0933 MTHFDTIVIGGGPAGMMACISAGFYGKKALLLEKNKRLGKKLAGTGGGRCNVTNNGTLEDLLAGIPGNGRFLHSVF SQFDNHDIMSFFEDNGVALKVEDHGRVFPKTNKSCTIIDCLERKIKELGGLIKTQCEIVSVKKEDGQFIVKSADE AFTCQQLIITTGGKSYPSTGSTGFGYAIAKHFKLKVTHLEAAESPLLTDFPHKALQGISLDDVTLTCGKHQINHD LLFTHFGLSGPAALRLSTFIQGGETAYLDLLPQLTKEALLKKIETTREKSLKNALKTFLPERLAAFLSEGYDHKV KQLSKKDLEKILHKIKALPIPITGKMSLAKSFVTKGGIDLKEINPKTLESKTISGLHFAGEVLDINAHTGGFNIT AALCTGWVAGSLHY Streptococcus mutans NYSGXRC-6032b SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1008 MKHGIKALLITLSLACAGMSHSALAAASVAKPTAVETKAEAPAAQSKAAVPAKASDEEGTRVSINNASAEELARAM NGVGLKKAQAIVSYREEYGPFKTVEDLKQVPGMGNSLVERNLAVLTL Escherichia coli NYSGXRC-6032c SGX Pharmaceuticals 2004-10-16 active Selected HI1008 MDWLKQLPKKWLLLGSGVFMVILITLLVGIYLMVNKELQVDTTMWEETSLTTTTEVATDATKERAETMIYVDIKGA VKVPGIYQLKNQQRIWDALALAGGVSEEADTTQVNYAQKVKDQMIIYVPKKGEPVAQSLETLQESAPAQQNQEEK INLNTATEAELQTISGIGAKKAQEIIRFRDEQGPFKTVEELKNVPGIGEKTVERLKDMLTVTG Enterococcus faecalis NYSGXRC-6032d SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified HI1008 ICEDB: T1158 GENBANK NP_358450.1 MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITV DVKGAVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISK EKKVNLNKASLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD Streptococcus pneumoniae NYSGXRC-6032e SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1008 GENBANK NP_251830.1 MHLIKSALLLILFACLPFSASAAPVAVAKNPLAATTPATTVSPGEQVNINTVDEAALIRGLNGVGEAKARAILEYR AAHGPFVSVDQLLEVKGVGPALLEKNRARIVIE Pseudomonas aeruginosa NYSGXRC-6032g SGX Pharmaceuticals 2004-11-17 active Selected Cloned Expressed Soluble HI1008 GENBANK NP_216931.1 MRTELPAERLQRRLGAVPDIDSHAASAHLDPEPHDPTDDGPDHDEPRDDPNSLLPRWLPDTSRGQGWADRIRADPG RAGAVALAVIAALAVLVTVFTLIRDRTEPVMSAKLPPVEPVSPTNPRSSASPGSPDRSGLPVVVSVVGLVHTPGL VTLAPGARIADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAPPSGQPRVLGSSVGAGTPGPAGTSGTATTG PKTAPKTAEVLDLNTATVEQLDALPGIGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKRRNLVRV Mycobacterium tuberculosis NYSGXRC-6032h SGX Pharmaceuticals 2003-06-06 active Selected Cloned Expressed Soluble Purified HI1008 ICEDB: T1157 GENBANK NP_721053.1 MVDEFLDKLKEKKNVFALVGGLVVLLGLGVYFFFPSSNKQEDSLARLKEQSLQVTTKTGKESQKKTQTTAKSTITV DIKGAVKHEGVYTLPIDSRINDVIEKAGGFSEKADRKSVNLAQKLQDEAVIYVAAIGENISVIRDSQEGKTSQAD KANTKETSVKGKVNLNTATLADLQTISGIGEKKAQDILDYREANGGFKSVDDLKNISGIGDKTFEKLKDLVSVD Streptococcus mutans NYSGXRC-6032i SGX Pharmaceuticals 2004-11-11 active Selected HI1008 MKHGIKALLITLSLTCAGMAHSALAATPVAKNAAVETKADTPSSSSAKAALPAKASDDEGTRVSINTASAEDLARV MNGVGLKKAQAIVSYREEYGPFKTVDDLKQVPGMGSALVERNLAVLTL Salmonella typhi NYSGXRC-6032j SGX Pharmaceuticals 2003-01-30 active Selected HI1008 MVELVKKYKNYILIGIAILCAGLVYIWIPDGKTDTVTANPTATKEEKPGKEEVKLPNYVYIDIKGAIRTPGVYKLP VNARVQDVVKTAGGLTDEADSGKLNLAEKLKDEMSIYVYKKGEEGPTLQGASAEETTSNLEKTNINSANKADLQQ VPGIGESKATAIIEYREKEGLFQTIEDLKNVSGIGEKTVEKLKEYLDVN Listeria monocytogenes NYSGXRC-6032k SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble Purified HI1008 ICEDB: T1159 GENBANK NP_269503.1 MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQSKAAVPALREISPVKQQVSEEKKEIQEDSSIL VDLKGAVQKEGVYKLTASSRVRDVIELAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKET ASKDQSKVHINKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIFLD Streptococcus pyogenes NYSGXRC-6032l SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI1008 MQIKTKIVTLFLSLCLPTLPLLANAEETAPAAQVEEGIVITVNINTASAEELATLLKGIGLKKAQAIVDYREANGP FTHIDDLTNVKGIGEATVRNNAARILL Vibrio cholerae NYSGXRC-6032m SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI1008 VKNKKAVVGSITIIFIFVVLIFIGYEVESRGEDNSSNVSVSEVMNNKKSKKSNENETKEVSAQIFGAVKNPGVYSL KSNSRVKDLIDQAGGFLDNADKFSINGAAKLVDGANIYVKAQGEKDSKVTNTSSSQENTQPQQNSSGEDKLDINT ATVDDIVSKKIKGIGKGLAQRIVDYREKNGGRISSVEDLQKAIGKKRGQDLMDYVNIN Clostridium acetobutylicum NYSGXRC-6032n SGX Pharmaceuticals 2004-11-12 active Selected Cloned Expressed Soluble Purified HI1008 ICEDB: T1149 GENBANK NP_293931.1 MTKTLLSALAALLLSTAAFAQTAPTPVHAAPTQTASSQTAPTTSTHTPKARTATPRTTAPLPTAPVNVNTATAAQL MTLPGVSNKIAAEIIKDRPYKNAAELVKKVKGIGKNNVKPMTPYLAF Deinococcus radiodurans NYSGXRC-6033b SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1011 GENBANK NP_417217.1 MIKIGVIADDFTGATDIASFLVENGLPTVQINGVPTGKMPEAIDALVISLKTRSCPVVEATQQSLAALSWLQQQGC KQIYFKYCSTFDSTAKGNIGPVTDALMDALDTPFTVFSPALPVNGRTVYQGYLFVMNQLLAESGMRHHPVNPMTD SYLPRLVEAQSTGRCGVVSAHVFEQGVDAVRQELARLQQEGYRYAVLDALTEHHLEIQGEALRDAPLVTGGSGLA IGLARQWAQENGNQARKAGRPLAGRGVVLSGSCSQMTNRQVAHYRQIAPAREVDVARCLSIETLAAYAHELAEWV LGQESVLAPLVFATASTDALAAIQQQYGAQKASQAVETLFSQLAARLAAEGVTRFIVAGGETSGVVTQSLGIKGF HIGPTISPACRG Escherichia coli NYSGXRC-6033c SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1011 GENBANK NP_461838.1 MLKIGVIADDFTGATDIASFLVENGMPTVQINDVPTGTQPEGCDAVVISLKTRSCPAQEAIKQSLAALVWLKKQGC QQVYFKYCSTFDSTAEGNIGPVTDALMVALDTSFTVISPALPVNGRTVYQGYLFVMNHLLAESGMRHHPINPMTD SYLPRLMEAQAQGRCGVIPAQTLDEGVAATRAALSRLQQEGYRYAVLDALNERHLEIQGEVLRDAPLVTGGSGLA MGLARQWAKHGVSQARSAGYPLSGRAVVLSGSCSQMTNQQVAFYRQHAPTRDVDVARCLSSETREAYAEALAQWV LSQDSELAPMISATASTQALAAIQQQYGATEASHAVEALFSLLAARLAEGGITRFIVAGGETSGVVTQSLGITGF HIGPCISPGVPWVNALHAPVSLALKSGNFGDESFFIRAQREFQV Salmonella typhimurium NYSGXRC-6033d SGX Pharmaceuticals 2003-01-30 active Selected HI1011 VRIGVIADDLTGANATGVRLVKQGFPAATVVHSASVPSGDNYQALIMDTDSRYVRSAIAAKRVTDAMNQLKRWGAR MFTKRIDSTLRGNIGVELDTMLAELGESSVAIVMPSFPDSGRTVTGGYLLVHGVPVQDTFVSKDPVSPIITSYVP DLLRKQTKHPVGYVGLHEVMSGRNVILQHVEQLISEGKRLIVIDAVTNEQVDDVAKAVAVIKDRPIVPACPGPFT AAYVRAVTQQQQEDARLLVAVGRLPH Bacillus halodurans NYSGXRC-6034a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1016 GENBANK NP_439177.1 VIRCTDINEITPFSSFISKIPNHCGTHMDASRHFVKDGLSINELPIGYFCHKDVVLLEVPKGEAEGITKEDLEPYA AILAQVSFAFLCTGFEKYRTENPLIYQNEGPYIATSAGKYLSDNYPNLKGVGIWFPCTWFAVFSCT Haemophilus influenzae NYSGXRC-6034b SGX Pharmaceuticals 2003-01-30 active Selected HI1016 VFIELSYPIEERMLTYPDNPPDYFEPKSRIEQGDAANTMMIHHFSHTGTHVDAPYHFCEEGWTLDQIPLEYFIFEK PLLVDREKKPMELFTIEDIEELDLNGVDLLMFRSGFAKLRRTDPATYRYMFPGISKELARFLRESVLSLKAVMLD FLSADPIVLGEKENYPAHRWLLSKKFSSKRPIIIFEDVNLEPVAGKKIKRVIALPLRFKGLDGGPVSVLAEVE Thermotoga maritima NYSGXRC-6034c SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1016 ICEDB: T1169 GENBANK NP_216232.1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPF LDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKKAGEWF AAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFEN VGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV Mycobacterium tuberculosis NYSGXRC-6034f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1016 MHIVDLSYPVTADMPLWPGTPAPNFSDLHTVGRDGFGERWLQLSSHTGTHLDAPAHLFEGAVSLDRLPVDHFIGKG ALLDLRDAQPEPLSLDQLLLQRATIESAEFLLLHTGWSRFWGTAAYDRGYPVFAEEAAAWLAGLGLKGVGIDAPS FDDPDSEELPIHRRLLGAGFVLIENLTALDRLGGHEFFLSVLPLPIAGAEACPVRAVALIASFAANQPI Chlorobium tepidum NYSGXRC-6034g SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1016 GENBANK NP_344380.1 MIEELFDQMSKGNLLLIDMTYDMFNGMQTYIGDPPFKHEYFRKGNKYGEVTLSTVYMGLHSGTHIDLPLHFVPNGE SVEKFNIIQFIGYGNVLDLSYKKLGEPISSNDLKKFDDRIKENYVVMLYTGFSATRGKEDFLYNWPYLDSNGADY LVSKKIRAVGIESMSIAGWAGKEYPPRTNWDEVVYVHHKLLSNDIIILESVNNMKKVLEECKNGEALFFYAPLKI VGAEGGPTRLFAICEKR Sulfolobus solfataricus NYSGXRC-6034h SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1016 GENBANK NP_394190.1 MIMIHIKAIHDLTVPLETYMPIWPTNPLLEIKPVGTVARDGYKIETISGSTHSGTHIDAPAHMLENGITIDQIDPI RFIGTGYCIKTIPDGNFVRSTHLIEKWKEEYDGSIILIETGWYKKRGFTREFQYEFPGLTEDAAEFLIERNVKLV GIDTLGIEPYQDSDFHVHKKLLSKGIPFIEDLYGLDDLEEGKPYLVVALPLKMKGASGSMARVMALEMD Thermoplasma acidophilum NYSGXRC-6036a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1031 GENBANK NP_439191.1 MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGDIVPNAIPTKVLSLGSI EQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKE CRIGTNPLIIAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKG SGLSIVLDMIATLLSNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQAVR LPGHEFTTILSDNQTNGIPVDERVWAKLKTL Haemophilus influenzae NYSGXRC-6036b SGX Pharmaceuticals 2005-02-10 active Selected Cloned Expressed Soluble Purified HI1031 ICEDB: T1175, T1179 GENBANK NP_418032.1 MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAI EQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKE CRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKG SGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR LPGHEFTTLLAENRRNGITVDDSVWAKIQAL Escherichia coli NYSGXRC-6036c SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1031 ICEDB: T1177 GENBANK NP_248429.1 MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGNINPKPDIKIVKESPAT AVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIAGYYSELAMNQDMIGITITNTEPAMAPFGGKE KILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALEGCILPFGGPKG YGLALAIEMLSAIGGAEVGTKVKGTANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGFEIL IPGEIEERNKMKRKDGFEIDKNLYNQLKEICNELGLNIEDYIE Methanococcus jannaschii NYSGXRC-6036d SGX Pharmaceuticals 2003-01-30 active Selected HI1031 MKVTFEELKGAFYRVLRSRNIAEDTADECAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDAKPQRVTSLGAI EQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKE CRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKG SGLSIVLDMIATLLSNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAIR LPGHEFTKLLDDNRRHGITIDDSVWAKIQAL Salmonella typhimurium NYSGXRC-6036e SGX Pharmaceuticals 2004-11-10 active Selected HI1031 MFEKGYVDENYIRVPKDRLFSFIVRVLTKLGVPEEDAKIVADNLVMADLRGVESHGVQRLKRYVDGIISGGVNLHP KIRVIREGPSYALIDGDEGLGQVVGYRSMKLAIKKAKDTGIGIVIARNSNHYGIAGYYALMAAEEGMIGISMTNS RPLVAPTGGIERILGTNPIALAAPTKDKPFLLDMATSVVPIGKLEVYRRKGKDIPEGWAINREGNITTKVEEVFN GGALLPLGGFGELLGGHKGYGLSLMVDILSGILSGGTWSKYVKNTSEKGSNVCHFFMVIDIEHFIPLEEFKEKIS QMIEEIKSSRKHPEFERIWIHGEKGFLTMETRLKLGIPIYRKVLEELNEIAKRVGVEGL Pyrococcus horikoshii NYSGXRC-6036f SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1031 ICEDB: T1174 GENBANK NP_347205.1 MNLWGDRVGYSKYKYEGLLNLCLEVFQRLGYTKEDSYTIGEVLLLADLFGIESHGVQRLTLYYKGIRNGSIKVKNH MNIVKESPVSVVIDGDGGMGQIISKKAMERAIDKAKKTGIGMAIVKNSNHFGIAGYYSRMAERKGLMGIAMTNTR AIVLPTYGREQMLGTNPISIAMPARPIPFLLDMATSVITRGKVEVYSKNNQKLNYGWAMDDEGRKTDNPDKVLKL ANGNTGGLLPLGGDTEIFGGHKGYGISFAVEMFTSILSGGLTSDEIRGNNNTNGVCHAFAAIDYGLFDDKNAIEK RMSAYMQKIRNSKKAYGASRIYTHGEKELEAYEDRMENGIPINENTIVEIKEICDYVDIDINNYLKKY Clostridium acetobutylicum NYSGXRC-6037b SGX Pharmaceuticals 2004-04-08 active Selected Cloned Expressed Soluble Purified HI1044 ICEDB: T1180 GENBANK ZP_07099943 MLGMTHFSQQDNFSVAARVLGALFYYAPESAEAAPLVAVLTSDGWETQWPLPEASLAPLVTAFQTQCEETHAQAWQ RLFVGPWALPSPPWGSVWLDRESVLFGDSTLALRQWMREKGIQFEMKQNEPEDHFGSLLLMAAWLAENGRQTECE ELLAWHLFPWSTRFLDVFIEKAEHPFYRALGELARLTLAQWQSQLLIPVAVKPLFR Escherichia coli NYSGXRC-6037c SGX Pharmaceuticals 2003-01-30 active Selected HI1044 MTTFLQRDDFAVTARVLGALFYYSPESHETAPLVQALLNDDWQAQWPLDAEALAPVAAMFKTHSEESLPQAWQRLF IGPYALPSPPWGSVWLDRESVLFGDSTLALRQWMRENGIQFEMQQNEPEDHFGALLLLAAWLAENGRHHECEQLL AWHLFPWSPRFLDVFIDHAGHPFYQALGQLARLTLAQWQAQLIIPVAVKPLFR Salmonella typhi NYSGXRC-6037d SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1044 GENBANK NP_279807.1 MTPATRNNDSAVAVADAFDDTGDGPPTAARFAALAACWRQPDDDLQAALAAETDTTVDAQSLRAEYTRLFVGPGPS QSPPYESVYRDGERDADLGPVYGSSTQAVARWYSEYGLQPAASESAPPDHLATELEFAAYLREHEGAETLEQFLT EHPRNWVESFARRVRDADPKPFYRTLLNVTVDTLARADTPL Halobacterium sp. NRC-1 NYSGXRC-6037e SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI1044 MRSQSTHSQSMRSDIYLLLATLLRDVPSAELCAFLAELDFEANGTEMAKAWQAMSAAAQNAQADSLADEYQELFIG IGRGEVVPFASWHLTGSLMEKPLADIRDDLSRLGLERDEQVREPEDHISALCETMAYLCEESGDENAAEETQQAF FNRHIAPWFGKLVSQIRQAPHAQFYLAVAQLLDAFLSLEQVAMTQAPSSRKNRYRIEVKNLTDKAEQ Vibrio cholerae NYSGXRC-6038a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1119 GENBANK NP_439276.1 MAIQMTTKTTYQWPQSKDIYPYRPGRFDAPKHWRYNLRSFLNRGSIRRFEQFINQHPFLIDIFNTHLDYSYPVACR FLDKRFNASQRFHAVCENLLFLPEKLTALSTPLWEKPLSFGEVIPDFEMTLSMTTHQPMEGYWVLELWHKPRNEL VYLLTFAKLGDALLIAVVQGPNFEGSKEMVKQLTKLCHGLRPAYLMVETMKSLTKILGYNKLLGIPQKYQNKSRF IQSKQYTVDYDAIFGESGGELKDYWELPLEMDRNLDDIPSKKRSMYRKRYAMLDDLAKVIEEKLGL Haemophilus influenzae NYSGXRC-6038b SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1119 GENBANK NP_274375.1 MKQNRTFTFPDFRTVYSYAPLYRLQHLKYTLRKFFGKKEIYAFEQFVNASPIRQGLFLHCPQNAYPLLREFVDRRF NCKRRLDAMTADFLMAEKLFGTDILHQMEDYRFHLVLAHLSDGISLWLNRNDNCVEEGAWSLSLRDEAGNRLYMA TFAFVGTHLLTASVQGPAGEEAKDTVRRITKQLHGLRPQQLMVTALQYFAAVLGLDGAMGIAQKHQVKLRWKLKK RVKMNYDAFWQEYGASLERDGYWHLPQTPARKDLADIESKKRSMYRKRYEMLDNMVAEMKDSLKTEARGISDGIQ TEKPPRRTA Neisseria meningitidis NYSGXRC-6038c SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1119 GENBANK YP_002344462.1 VNKKFSYPIPNFTDRRKSIIFWRYLRFQARKILYFPQVRLLEKTLNKEKNKHLKDFFSQRPYACYNATRRFCDKSF KANERVKTLIYDVDKGLACFKFLPEEQIIFSFDEDFELFLGYNYNVCEEGFWAFSLKFKKYTILQCNFCFTLENN LLLSCIQGHKYKDFNILEINKILTKKCHGLRPVALLIECSKMLCEILKLQATLGVHEKNQIRSQKGKEKGYFVDY QKIWLENGGELIKINKHKYYKLHHSQKNLEEIPSQKRSMYKKRFAMLEEIKTNLDKTLSIQD Campylobacter jejuni NYSGXRC-6039a SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI1151 MAKRKKKEVFDWEDEDQEEIIWVSKSEIKRDAEDLKQLGEKIVNLTKANLAKIPLDESLLDAIELAQRLQKEARRR QLQYIGKLFRGIDVEPIREALDKIENKHNQQQAMLHKIEKVRDELVEKGDVALTDLLNDYPNGDRQQLRNLIRSA QKELEQNKPSKAYREIYQMLKVLMLED Haemophilus influenzae NYSGXRC-6039b SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1151 GENBANK NP_253163.1 VAAHAAGPDKRPLTRYHGGVFHWTTTMAEFHDDDSQFEEKSKSQIKRELHALQDLGERLTTLQPQLLERLPLTDPL RKALLEAPKHKAHIARKRHIQYIGKLMRDQDVDAIVALIDQVDSSTRQYNERFHALERWRDQLIAGGDAALDAFV GEFPECDRQHLRGLVRHAQHEAAHNKPPAAARKVFKYIRELDETKRGLR Pseudomonas aeruginosa NYSGXRC-6039c SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1151 GENBANK NP_214908.1 MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTTREICESVGGADTVLSRIDKNPELEPLLSQAI EAATRTSMEAKRRLLAQAAAAALEDDQKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAA SKVEPVPVLAALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSGGSAP TGDHPTPHPSTSR Mycobacterium tuberculosis NYSGXRC-6039d SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1151 GENBANK NP_709967.1 MTKQPEDWLDDVPGDDIEDEDDEIIWVSKSEIKRDAEELKRLGAEIVDLGKNALYKIPLDADLRPAIELAQRIKME GRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLENLRDRLIDQGDDAIAEVLNLWPDADRQQLRTL IRNAKKEKEGNKPPKSARQIFQYLRELAENEG Shigella flexneri NYSGXRC-6039e SGX Pharmaceuticals 2003-01-30 active Selected HI1151 MTKQPEDWLDDVPGDDIEDEDDEIIWVSKSEIKRDAEELKRLGAELVDLGKNALDKIPLDADLRDAIELAQRIKME GRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLEHLRDRLIVEGDDAVAEVLTLWPHADRQQLRSL IRNAKKEKEGNKPPKSARQIFQYLRELAENEG Salmonella typhi NYSGXRC-6039f SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1151 ICEDB: T1190 GENBANK NP_273881.1 MRYWKNSRIKMFEQEDEWISKTQMKKQMNDLQDLGMALTKLSNDTLKKIGLDADLYEAVTAYKKITSNGALKRQAQ FIGRLMRDTDPAPIEAFLAKLRGDDAAHNAFLQRVEQARVRLLADDGALTQFMSDFPHADAGKLRTLIRNTKKEQ EQNKPPKNFRALFQELKTVMENGDAEI Neisseria meningitidis NYSGXRC-6039g SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble Purified HI1151 ICEDB: T1195 GENBANK NP_232164.1 MMKNMARKNQKAPWEEEEEIIWVSRTELKNDMLALQKLGEELVELKPSALAKFPLPEDLAEAIKDAQRFKNEARRR QLQYIGKLMRHIDPEPLQAALDKLRNKHSQTTALLHKLEQLRDRIVAEGDSAIEVAMEQYPEADRQRLRLLARQA SKEKAGNKPPKSSREIFQLLKEAMLAKQEIEEESEDDLDSAE Vibrio cholerae NYSGXRC-6039h SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1151 MRAMSRASRHNPSYLQPVVRTDIGDEDDPGTPKSKSQRKREVTALQDLGTALEALPKDRLAKVPLPETLADALREA RRITSHEGKRRQMQYIGKLMRALTDDDIEAIRRVLATFVGASKAETARLHAIERWRDRLLADDGAITEFIAAHPD TDVQALRTLVRNARKEAQLGKPPKSSRELFQAVKQALAGHDQAGEDAEPSNLEDDQA Ralstonia solanacearum NYSGXRC-6039i SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1151 MWKNGAMRGCNKETGEFLGPSRSQQRRTALEVLVLSEKLAALTPAQLAKLPIPERLLPHITETKRITSHIARKRQL AFLAKQMRREDDTTLETIREKLDASGIQAQREVATLHRTEQWRKRLLEEGDSALTELLNQYPQADCGKLRQLLRN TKTEQARNKPPQAFRELYQVLHGLIITQNSDNQH Xylella fastidiosa NYSGXRC-6040c SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1189 ICEDB: T1207 GENBANK NP_371234.1 MAKIPVLEIFGPTIQGEGRVIGRKTMFVRTAGCDYRCSWCDSAFTWDGSAKGDIKLMTAEEIYDELKRIGGDLFNH VTISGGNPALIKGIQELVDLFQDKGIFSALETQGSKFQPWMTQIDDLTISPKPPSSTMTPDLKKLDEVITQCVPS SLNLKVVVFDDKDYDFAKMIHHRYPDIPFYLQVGNPYLSDSVDNHTEKLLERYEQLVDLVMQSNDMNHVYVLPQL HTLLWSNKKGV Staphylococcus aureus NYSGXRC-6040d SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble Purified HI1189 ICEDB: T1209 GENBANK NP_228634.1 MRNPPFIVEYELTLRCNFRCKHCYCEAGKPHLEELSFEEIKELILDMKELGTWALDIVGGEPLLHPQILDILAFGK EVGQRLMINTNGSLATKEMVQKIKKANPDVLIGVSLEGPDPETNDFVRGTGNFKRAVQGIKNFVDEGFQVTILNV INKRNWRKFEDMVKLALELGVNALYVDRFIPVGRGMIHARELDMNPEEWRVAIKHVLGVIENYKNHLTFYVEESI SGKPCSAGITHASVLADGTVVPCGHFRYRKEFYMGNVREKKFSEIWHEYTPIPSPASCQQCPILNECGGGCKAYY LLREHEKDEAICFLNKERYNIK Thermotoga maritima NYSGXRC-6040e SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1189 ICEDB: T1202 GENBANK NP_247815.1 MKDKFGREIRSLRISITNKCNLQCFYCHREGHDSNNDRYMTPEEIGIIAKTSTKFGVKKIKISGGEPLLRKDVCEI IENIKDERIKDISLTTNGILLENLAEKLKDAGLNRVNVSLDTLNPELYKKITKFGDVERVINGIKKAIDVSLTPL KVNFLAMSINIKDLPDIMEFCRDIGAILQIIEFIPLKEELKGYYYNISPIENEIKEKADKVITRNFMQNRKKYIV DGLEIEFVRPMDNSEFCMHCTRIRLTYDGYLKPCLLRDDNLVDVLTPLRKGENLEPYFIECINRREPYFKIK Methanococcus jannaschii NYSGXRC-6040f SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1189 GENBANK NP_815114.1 VNSMKDAFNREIDYVRLSLTDRCDLRCTYCMPATGLCFLKKEQLLTDDEIIFLLRILAKEDIKKVKLTGGEPLVRP NLLSLIKRIKQISGIEKVTLTTNGMKLAREAQGLKEAGLDGINISLDTLDPEEFREITRVGQLRNVLAGLEQAID VGLPNIKINTVARKELSEATIVELAEIAKKETVHLRFIEMMPIGLGKEHPGKQQEEVEAILTKYYGTLQPYQKPL GNGPASYYALKDFKGKIGFISALGHCFCETCNRIRITADGHLKTCLHSADGYSLKEALAMEQTAELLGIIKSGIA CKPEKHLFLEQQGEQRFMSQIGG Enterococcus faecalis NYSGXRC-6040g SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1189 ICEDB: T1203 GENBANK NP_273574.1 MKKINVAPENPQYRIVEIFESLQGEGWNTGMPAVFVRLGKCNLACGWCDTDYLTFGMMGLSDILGRLKTYAARNII ITGGEPTIQPHLDMLLDTLKAEGYFLCLETNGLNPAPPQIDYVATSPKACYAAKYENSCIETADEVRIVADGDVL AFCENMERKIRAHHYYLSPCEQDGAMNIYDTIRQIGILNSRPDASVHWQLSVQTHKWAGIE Neisseria meningitidis NYSGXRC-6040h SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1189 MTYAVKEIFYTLQGEGANTGRAAVFCRFAGCNLWSGREADRAAAICQFCDTDFVGTDGTLGGKYPTADALADTVAA QWPAAATGGRPLVVCTGGEPLLQLDRPLIDALHARGFEIAIETNGTLAVPDGIDWVCVSPKMGAELVVTRGDELK VVIPQPGQDLDAYERLDFRHFFLQPMDGPLARRNTALAVELCQRRPRWHLSLQTHKMLGIR Ralstonia solanacearum NYSGXRC-6040i SGX Pharmaceuticals 2004-10-16 active Selected HI1189 MTYSVKEIFLTLQGEGGQAGKAAVFCRFSGCNLWSGREQDRAKAVCTFCDTDFVGTDGENGGKFATAEDLAAAVEA QWTGGPDDRLVVCTGGEPFLQLDDAAIAALHARGFQIAVETNGTITAPAGVDWICVSPKADAPVVQTSGQELKLV FPQEKAMPERFAALDFERFYLQPMDGPDRDANTQLAVAYCLSHPQWRLSVQTHKYLGLP Caulobacter crescentus NYSGXRC-6040j SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1189 MLVNEIFHSLQGEGANTGRAAVFVRLAGCNLACPYCDTDFAQGKKMSLEEIARSIEHYPTRFLIWTGGEPTLQLTE EATAYFHRLGYFQAIETNGTRPVPKGIDYISCSPKTGAIGKLKENFPDGVGEFRFPLGSDTPLPPPIDELPTAQH YLVSPIFAGDDAMEPDPSAITRCVEVKAFPWRLSIQMHKLIHIP Porphyromonas gingivalis NYSGXRC-6040k SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1189 GENBANK NP_231009.1 LTSIAISIMVCHLQLFIHVRSFILYRINEMFEIIQGEGVFTGVPAVFVRLQGCPVGCAWCDTKQTWETLDSDQTSF SQILLKTNDAPTWCQATAQEVVQRYQAQGYQAKHIVITGGEPCIYDLTELTQAFEAMGCRCQIETSGTYEVCATE NTWVTVSPKVAMKGKLPILDSALQRANEIKHPVATEKDIDNLDELLARAQVSAQTAIALQPISQKPRATELCIRT CIARNWRLSIQTHKYLNIA Vibrio cholerae NYSGXRC-6040l SGX Pharmaceuticals 2003-01-30 active Selected HI1189 MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWDKLSDREVSLFSILAKTKESDKWGAASSEDLL AVINRQGYTARHVVITGGEPCIHDLMPLTDLLEKSGFSCQIETSGTHEVRCTPNTWVTVSPKVNMRGGYDVLSQA LERANEIKHPVGRVRDIEALDELLATLSDDKPRVIALQPISQKEDATRLCIETCIARNWRLSMQTHKYLNIA Salmonella typhi NYSGXRC-6040m SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1189 LNDQRHNNRLMNATRSQLKISEIFLSLQGEANSVGWPTVFVRLTGCPLRCQYCDTAYAFHGGEWCSIDTIVSEVRS YGVRHVCVTGGEPLAQKRCLLLLEKLCDAGFEVSLETSGALDIAAVDLRVSRVVDIKTPGSGEAHRNHWPNLALL TPHDQIKFVLCSRADYEWARTCVAEHELERRCMVWFSPSKQDIAPTVLADWIISDRLGVRFQLQLHKLLWNDEPG R Xylella fastidiosa NYSGXRC-6040n SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1189 MPVSETTDRQASNGGDGPALPINELFYSLQGEGKLAGTPSVFVRTSGCNLRCWFCDSYHTSWEPTHATMSVDDIIA EVQSYEHADHVVLTGGEPLLHDDAVVLLDRLAALGYHTTVETNGTIHRDAPIDLASVSPKLASSTPTAETDPKGD GEWAARHDARRIDVATLGALADDYDTQLKFVVTDPSDMPEIESLLAEIRTATDTRIGDEDVVLMPEGTTHAELDA RRNEVATLAMEHGYRYTPRLHVALWNDAPET Halobacterium sp. NRC-1 NYSGXRC-6040o SGX Pharmaceuticals 2003-01-30 active Selected HI1189 VVQMKYRVIEIFTSIQGEGEVIGIPSNFIRLATCNLRCVWCDTKYSWEIGTEMSIDEIIAKLDKKIKTTTITGGEP LLQNILPLAKELKSIGHKIVVETNGTIKPSEELRKIIDIFSVSPKLSNSGHKLKYDFADDWATYYKFVIVYPNKD IDEVVKFVESQSINPRKVILQPDGNRSDYINAINEIVQIVLDRGLQFRVLPQLHRIIGAR Sulfolobus solfataricus NYSGXRC-6041b SGX Pharmaceuticals 2004-12-04 active Selected Cloned Expressed Soluble Purified HI1202 ICEDB: T1215, T1219 GENBANK NP_416834.1 MKKKTTLSEEDQALFRQLMAGTRKIKQDTIVHRPQRKKISEVPVKRLIQEQADASHYFSDEFQPLLNTEGPVKYVR PDVSHFEAKKLRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPH VMAFHQAPKEYGGDAALLVLIEVEEWLPPELP Escherichia coli NYSGXRC-6041d SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble Purified HI1202 ICEDB: T1221 GENBANK NP_231750.1 MSKNDHRITHNKSDKDNLDDDFSLFRDEVKGVKKLRQDTILHAPNRNPKQKEIRRTEREASDNDFYFSDEFMPHLT DEGPTRYARSDVSKYEVKRLRRGVYVPDVFLDMHGMTQQEAKRELGAMIAYCLKENVHCACVQHGIGKHILKQNV PLWLAQHPDVLAFHQAPLEFGGDGALLVLLSIPEK Vibrio cholerae NYSGXRC-6041e SGX Pharmaceuticals 2004-11-11 active Selected HI1202 MKKKTSLSEEDQALFRQLMVGTRKIKQDTIVHRPLRKKITEVPTRRLIQEQADASHYFSDEFQPLLNTEGPVKYVR EDVSHFELKKMRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHIFCACVMHGHGKHILKQQTPLWLAQHPH VMAFHQAPKEYGGDAALLVLIEVEEWQPPELP Salmonella typhi NYSGXRC-6041f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1202 MTQHNDNDDDAALFRAAIGPVRPLRPSEMAITIKPPSRPRRRIIQHHQDEAKSKFAQLLRESAPLEAGDTISYRSK ALPSRLFQRLKRGQFSVQDELDLHGATVVQAETLLRQFLLEAHMYEYGCVRIIHGKGLQSNGGTPVLKNLVNQLL RLRKDVLAFHSSPPAQGGTGAVLVLLTHH Xylella fastidiosa NYSGXRC-6041g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1202 MKRAHPPASRLDLTDLAALRDQLKHETEQREAERQRAEAAARQAEAEADLFRASIGEVSALRQGKRVEHPRTPPAP QPVHSRAEEQRVLRASLSDEFDVDNLLDTDDTLSYRRPGIGEDVLKKLRRGEWATQDQIDLHGLRRDEAREALAA FLRRAVQRGIRCVRVVHGKGLGSPDKAPVLKGKVRSWLVQKEEVIAFVEPRNTAGGAGAVLVLLRQPHGS Ralstonia solanacearum NYSGXRC-6041h SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI1202 MNTDFQNILKQLGKQAQKEAAEKQAAEKNKQKQEQDFDFSQAVGQLSPLKNRQQYYAPPDKTPIKVRPKDNRADEE NYFYIGSTYNDPPASFSKNGQGKNDIQRLKNGYYPVVTDVDLHGYTQEEAQKVLNEFIAFTQKRGVCGEIIHGSG LGSKGYKPVLKNMTRNWLMQHPDVLAYAEPREGNDGCVRILLKRKLRQQD Neisseria meningitidis NYSGXRC-6041i SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1202 VAKKPPPGPEDDKRLWRLVASTVTPRAPVKPEKMRSKARIRPSLKSDAALPAEPPTRLASIAPLRLHPEDLKPAAP KPLKGPAGHIEPNRKLRIVKERDPIGARLDMHGLDQDQARATLEAFIRRSFSQGHRAVLVITGKGKIGQGVLRSR TPEWLTDPSLREMVAGVSTADRRHGGEGALYVALKRRV Caulobacter crescentus NYSGXRC-6041j SGX Pharmaceuticals 2003-01-30 active Selected HI1202 MNTKILKALEFDKVKKQFTHFLQSEQGQMELNDLLPMTNQEKIERSFAEIADVAQIFQEYASFGFGHSQDISESLR RLELGADLNTQELLAVKRILQMSAELKDFYDNLENVDLQILDCLFEKIETFPDLQGSLQAINDGGFIEDFASPEL TKIRHHIHQNEQQIRQILQEMLKKQGDLLAENLIASRSGRSVLPVKNTYRHRIAGVIHDISASGNTVYIEPRAVV NLNEEMTQARADERHEMTRILHDLSDRLRSQTDIIGNNAWLLGHIDFVRGKYLYMRENQASLPSLTTDQTIRLLS VRHPLLSNPIANDLHFEHDTTAILITGPNTGGKTIMLKTLGITQLMAQSGLPILADEGSKVAVFKDIFADIGDEQ SIEQSLSTFSSHMTHIVEILQKANKDSLVLFDELGAGTDPQEGAALAMSILEHLRLSDIKTMITTHYPELKAYGI ETEFIENASMEFDMVTLSPTYHFMQGVPGRSNAFEIARRLGLSEIIVAEAENLTNTDSDVNKIIERLENQTIESR RRLDNIREVEQENLKFNRAVKKLYNEFSHAQDKELRKAKLKAQEIVDKALAESDFILKNLQDKAQLKPHEIIEAK GKLKKLVPEIELSKNKVLKKAKKKRAAKVGDDIIVSSYGQRGTLTKRFKDGRWEAQVGLIKMTLQESEFDLVKSD KAQASQKRQAHLVKRTSQKAPSARLDLRGKRYEEAMQELDEFIDQALLNNMAQVDIIHGIGTGVIRDGVTKYLRR NKQVKEFGYAPQNAGGSGATIVTFK Streptococcus mutans NYSGXRC-6042a SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1223 MIELLFLLLPIAAAYGWYMGRRSAKKDQDDISNKLSRDYVTGVNFLLSNQTDKAVDLFLDMLQKQEIENEIESHSQ FEAELTLGNLFRSRGEVDRALRIHQALDLSPNYTFEQKLLAKQQLARDFMVVGFFDRAENLYILLVDEPEFAENA LQQLLVIYQKTKEWKKAVNIAEKLAKIKPQENNIELAQCYCEYSQSLEPESAVEKRSVLQKALSVSPTCVRASLL LANLAMLDGQYQQAVKILENVLEQNPDYTGEILLPLKHCYEELNQLDNFELFLIRAGQIINNDEVELALAKLIEE KDGKSAAQAKLYQQLTKKPSTLIFHRFMQYQIDDAEDGRGKESLILLHKMVGERIKQTSPYRCTNCGYQIHKLLW NCPSCRQWESIKPVSNQEHN Haemophilus influenzae NYSGXRC-6042d SGX Pharmaceuticals 2003-01-30 active Selected HI1223 MLELLFLLLPVAAAYGWYMGRRSAQQTKQDEANRLSRDYVAGVNFLLSNQQDKAVDLFLDMLKEDTGTVEAHLTLG NLFRSRGEVDRAIRIHQTLMESASLTYEQRLLAVQQLGRDYMAAGLYDRAEDMFNQLTDETEFRVGALQQLLQIY QLTSDWQKAIEVAERLVKLGKDKQRIEIAHFYCELALQQMGNDDMDRAMALLKKGAAADKNSARVSIMMGRVYMA RGDYAKAVESLQRVIVQDKELVSETLEMLQTCYQQLGKNAEWAEFLRRAVEENTGAGAELMLADILEAREGSDAA QVYITRQLQRHPTMRVFHKLMDYHLNEAEEGRAKESLMVLRDMVGEQVRSKPRYRCQKCGFTAYTLYWHCPSCRA WSTIKPIRGLDGQ Salmonella typhi NYSGXRC-6042e SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1223 MDCIDSMEFLDEWFWFFLFLPLAALSGWVIGRRGGQRHGHAQVSRLSSTYFRGLNYLLSEQPDKAIELFQHIAELD KETFETQVALGHLFRRRGEIDRAIRLHQGLLKRPDLTDHQKVFALLALGEDYMKSGLLDRAETVFTELAQIDQRA PQALRHLISIYQAERDWEKAIDNAIRYEVATGEPMGKLIAQFECELADRYRASNQHDRALEAVSRAYQADATSVR AGIIEGRIEADLGHHEAAVRAWERAARHDPEYLPEIIPALLIAYRQVGDIAGARNFLSEMTEHYRGIAPVLAMTQ LIESQEGPAQARGYLGSQLKAKPSVRGQSALIDLTLADGSDPVASLYDLKHITDQLLVRNPSYRCTRCGFGAKTH HWQCPSCKEWGTVKPLLNYAVV Xylella fastidiosa NYSGXRC-6042f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1223 MDFDLWWLLAIPLVFGLGWVAARLDARQLLTEQASLPRSYFKGLNFLLNEQPDKAIDAFIEVARLDPETTELHFAL GSLFRRRGETERAIRVHQNLVNRPDLPANERDHALYELGQDFLRAGLLDRAEESLRMLMEGVFAEPAKRVLLELY EVEKEWRKAIDAARELQTLQGQDYSVQIAQFCCELAQESLQRKDVSAAVEWLERALQENPKNVRATIQLGDVALG KGDTEGAIKRWRSIEQQNPAFLPLVAERLMKAYAQLGRAAEGLAWLRSKMDARLGPELLDVVYRYELDVHGIDDA VALMREQIRRQPSLMALTRLVEAEATRASEAVSHEAAAVAAPISDSALADPVEAGSNADIQRAQDLGAIRDLLQS RTRNLARYTCQECGFRARLFYWQCPGCNRWETYAPRRTEALGGSGGASM Ralstonia solanacearum NYSGXRC-6043a SGX Pharmaceuticals 2004-11-12 active Selected Cloned Expressed Soluble Purified HI1244 ICEDB: T1231 GENBANK NP_439400.1 MNPFQKIKSAVNKRQRFFINRTLQRKLTNQGMTVISANCVGAFILHDLHQPFNSPFVNLYLSPQDFLRYLQNIDFY LTQPLTFVQTEKSYPVGKLADLEIHFMHYHSEQEANEKWQLRTSRMKLDNLFIMMTDRDGVTEKDIQLFDQLPFK NKVIFTHKPYPAFKSAYYIKGFEKQNQVGDIFEFSGWNGKKYYDQFDYVKWFNHA Haemophilus influenzae NYSGXRC-6043b SGX Pharmaceuticals 2003-01-30 active Selected HI1244 LTENLTNVQVLQKMDDTDHRIRKQYRSLFGKLFNSKLLRKINQFDINNLIWRLYIHSKTATYINFPTYIDKPVIDA KPLKDSYKIILENYENRIKDCAVLENYDIERAKKQYIQELANFSAWLKNDGEYLDSDIVYHKLIAAEKGIFPFLE LDRLDFTIISNNCVGGLIYKQLGFQYRTPFVGLFILPDDYYKLTKHFRYYMEQELVFEEELISPSWTHEVYPLGH LGDIDIHFLHYSSIEEARTKWEKRKKRINWNNLYFKFDNKDSASEEILNKMDNLPYSNKLILVNRPYKNLKSQCV IPGQEHLPELAIMSDPLNTFDIMAWLKKGGNAL Streptococcus pneumoniae NYSGXRC-6044a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1287 GENBANK AAC22936.1 VPASARWQALQEVSILNTGAELPWGGKFSGVAKLIDDAFDAIEKDNEKLKGVLQRISGYAVNEDTLRGLIILFSDT HFTRPTYNGEPVHLGAKDILGHVYEYFLSRFAQAEGKRSGQYFTPKSIVSLIVEMLEPYSGRVYDPAMGSGGFFV QTERFITAHQGNINNVSIYGQEFNPTTWKLAAMNMAIRGIDYDFGKYNADSFTQPQHIDKKMDFIMANPHFNDKE WWNESLADDPRWAYGTPPKGNANFAWLQHMIYHLSPNGKIALLLANGSMSSQTNNEGEIRKAIINADLVECMVAL PGQLFTNTKIPACIWFLNRNKKRKGEVLFIDARQIGYMKDRVLRDFTADDIAKIADTLHAWQTSDGYEDQAAFCK SATLEEIKNNDFVLTPGRYVGTAEQEDDGVPFAEKMQNLTALLKEQFAKSAELEAEIKKNLGGLGYE Haemophilus influenzae NYSGXRC-6044b SGX Pharmaceuticals 2003-01-30 active Selected HI1287 MPPRKKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLVFLKYVSDAYDERREAIRAELAAEGMEESQI EDLIDDPEQYQGYGVFVVPVSARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPRLYNKDN IDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGNFARAEGKRGGEFFTPPSVVKVIVEVLEPSSGRVYD PCCGSGGMFVQTEKFIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGIDNKGLGARWSDTFARDQHPDVQMDY VMANLPFNIKDWARNEEDPRWRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVEA DLVSCMVALPTQLFRSTGIPVCLWFFAKDKAAGKQGSIDRCGQVLFIDARELGDLVDRAERALTNEEIVRIGDTF HAWRGSKSAAVKGIMYEDVPGFCKSATLAEIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLSKALLEAFDESA RLERVVREQLGRLR Mycobacterium tuberculosis NYSGXRC-6044d SGX Pharmaceuticals 2003-01-30 active Selected HI1287 MSITEKQRQQQAELHKKLWSIANDLRGNMDASEFRNYILGLIFYRFLSEKAEQEYADALSGEDITYQEAWADEEYR EDLKAELIDQVGYFIEPQDLFSAMIREIETQDFDIEHLATAIRKVETSTLGEESENDFIGLFSDMDLSSTRLGNN VKERTALISKVMVNLDDLPFVHSDMEIDMLGDAYEFLIGRFAATAGKKAGEFYTPQQVSKILAKIVTDGKDKLRH VYDPTCGSGSLLLRVGKETQVYRYFGQERNNTTYNLARMNMLLHDVRYENFEIRNDDTLENPAFLGNTFDAVIAN PPYSAKWTADSKFENDERFSGYGKLAPKSKADFAFIQHMVHYLDDEGTMAVVLPHGVLFRGAAEGVIRRYLIEEK NYLEAVIGLPANIFYGTSIPTCILVFKKCRQQDDNVLFIDASNDFEKGKNQNHLSDAQVERIIDTYKRKATIDKY SYSATLQEIADNDYNLNIPRYVDTFEEEAPIDLDQVQQDLKNIDKEIAEIEQEINAYLKELGVLKDE Staphylococcus aureus NYSGXRC-6044e SGX Pharmaceuticals 2003-01-30 active Selected HI1287 MENNPNNNQASLERNELHNTIWKVANELRGSVDGWDFKQYVLGILFYRYISENMTHYINKEERKRDPSFDYAKLSD EKAERGRKHLIEQKGFFIPPSALFCNALKNACHNEDLNVTLQNIFNEIEKSSLGTPSEENVKGLFADLDVNSNKL GSSHQNRVEKLTKILEAIGGMQLGDYLKSGIDVFGDAYEYLMAMYASNAGKSGGEFFTPQEVSELLAKITLHGQE SVNKVYDPCCGSGSLLLQFSKVLGDKNVSKGYFGQEINLTTYNLCRINMFLHDINYSKFHIAHGDTLLDPKHEDD EPFDAIVSNPPYSTKWVGDSNPILINDERFSPAGVLAPKNAADLAFTMHMLSYLSNSGTAAIVEFPGVLYRGNAE AKIREYLVKENVIDCVIALPDNLFFGTSIATCILVLKKNKQDDTTLFIDASKEFVKEGKKNKLKERNREKILQTY IERKEIKHFCALANIEKIKENDYNLSVNRYVEQEDTKEAIDIKALNSEIAQIVEKQSALRNRLESIIKELEGGQN A Helicobacter pylori NYSGXRC-6044f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1287 MARSDSDKNGNGGNLGFEAELFKAADKLRGNMEPSDYKHVALGLIFLKYISDAFEAKHKALLAEDALAAEDKDEYL ADNVFWVPKEARWSHLQANAKQPTIGTLIDDAMRAIEKDNASLKGVLPKDYARPALNKVMLGELIDLISGIGHLL PSPSGRGAGGEGQSFDILGRVYEYFLGQFAGAEGKRGGEFYTPRSVVRVLVEMLEPYSGRVYDPCCGSGGMFVQS EKFVQEHGGRIGDIAIYGQESNYTAWRLAKMNLAVRGIDADIRWNNEGSFHKDELRDLKADYILANPPFNISDWG GDRLREDVRWQFGVPPVGNANYAWLQHIYWHLAPNGTAGVVLANGSMSSNQSGEGEIRRAMLEADAVDCMVALPG QLFYSTQIPACLWFLARNKNPANGKTGGLRDRRGHVLFIDARKMGVLVDRTRRELSDEEIQKIARTYHAWRGEPD AGDYADVAGFCKSATLDEIRKHGHVLTPGRYVGAAEVEDDGEPFEEKMARLAAQWRQQRDEAAKLDAAIEANLKE LGFWE Chlorobium tepidum NYSGXRC-6044g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1287 MAHRKTTTKNGNGGTLGFEAELFKAADKLRGNMEPSDYKHVALGLIFLKYISDAFEAKHSALLAEDAQAAEDKDEY LAHNVFWVPKQARWSHLKANAKQSTIGTLIDEAMRDIEKDNPSLKHVLPKDYARPALNKVMLGELIDLISGIALN EEGARSKDILGRVYEYFLGQFAGAEGKRGGEFYTPRSVVRVLVQMLEPYSGRVYDPCCGSGGMFVQSEKFVLEHG GRIGDIAIYGQESNYTTWRLAKMNLAVRGIDSDIRWNNEGSFHNDALRDLKADYILANPPFNISDWGGDRLREDV RWKFGVPPAGNANYAWLQHIYHHLAPNGTAGVVLANGSMSSNHSGEGEIRTHMIEADIVDCMIAMPGQLFYSTQI PACLWFLARNKNPGKGLRDRRGQVLLMDARALGVLVDRTRRELTDEHIQQIADTYHAWRGEQGAAAYADVAGFCK SATLEDIRKQGYVLTPGRYVGAVEREDDGEPFPQKMQRLSAQWRAQRAAAAKLDAAIAANLKELGYGG Xylella fastidiosa NYSGXRC-6044h SGX Pharmaceuticals 2003-01-30 active Selected HI1287 MTEKAAKQNNSESFEQKLWKAADKLRKNIDAAEYKHIVLGLIFLKYISDAFEELHQKLLAGEGDYAGANPEDRDEY SAENVFFVPVEARWSYLQGQAKQPDIGKTVDLAMEAIEQENAKRLKGILPKVYGQQKLDQKSLGGLIDLIGSITL GDAEAQAQDVLGRVYEYFLGQFALAEGKKGGQFYTPESIVKLLVEMLEPYNGRVFDPCCGSGGMFVQSEKFVKNH QGRLDDISIYGQESNETTYKLCRMNLAIRGIDGSNIKWNPEGSFLNDAHKDLKADFVIANPPFNDSDWGGELLRN DGRWLDKDLVPPVGNANFAWVSHFIYHLAPTGSAGFVLSNGSLSSNTSGEGDIRKALVQKDLVDCIVMLPTQLFY NTGIPACLWFLSRYKNGNKNRDRHGEVLFIDASELGYMVNRSSRAFTEAEISKIADTYHEWKKSGGSYRDIKGFC KSASIAEIEKHNFVLTPGRYVGIPDEVEDGVSFEEKMSELTMALGEQMREGQLLDEEIKKQLLKVGFIVSDELVD F Nostoc sp. NYSGXRC-6044i SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1287 ICEDB: T1234 GENBANK ZP_01067682.1 MAKKKEIKLEDALWKSADKLRKNIDAAEYKHIVLGLIFLRYISDSFMQKYEELLKEQDDGADPEDADEYLADNIFF VPEKSRYNYIRDNAKNPKIGKMLDEAMDEIEKHNDTLKGVLPKVYAKDNLDSKCLGELIDLIGNIAFDTGKSTDV LGHVFEYFLGEFALAEGKQGGQFYTPKCVVELLVTMLEPYKGRVFDPCCGSGGMFVQSEEFVKSHQGRLDDISIY GQESNQTTYKLAKMNLAIRKIESSQVIWNNEGSFLNDAHKDLKADFIIANPPFNDSDWSGELLENDGRWKYGVPP ASNANYAWIQHFLYHLSPNGGVAGFVLAKGALTSNTTNEAAIRKALIEDDLIDCIVNLPAKLFLNTGIPASLWFI RRQKLPKTVKKTLFIDARDLGTRINRRNKTLNKDDINQIANIYKAWKNGTDYEDIKGFCKSVSIDEIRELSYVLT PGRYVGLADSDDEFDFDTRFNELLAKLKSQIKTEQELSEIILKNLEKIK Campylobacter jejuni NYSGXRC-6044j SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1287 GENBANK NP_269893.1 MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGL KDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQN QTISNVMKTLNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPA MGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLMN PPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQG AIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFDKGKNQNTMTDNHIKKILDAYKSRDNSDKFSY LASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN Streptococcus pyogenes NYSGXRC-6044k SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1287 MSLTLDELDSHLFKCADIIRDAVDPTDYKEYILPLVFYKAISDEYEQEREEIVEEYGEDFADNANLYDVPIVPEGH RWNDLRQESENVDEAINNAFTEFTQANPDLSGIFNANFMEAGGLTDDRLIKLVEHLSTYDLDRDSVPPDMLGEAY MDLVRHFAEEEGKSGGQFFTPPHIVQLCVRLVDDFADGMTFHDPTVGSGGMLTEAAKYYREAQGGDPSKLTFTGQ EINPDIAAIARMNLSLHTLNGEIERGDSLASPGFTDGDDLERFDRVLANFPFSADWAKDDLQDDQYGRFDWHTKL PRADRGDYAFIMHIAEQLKEPDCGDESGGKAAIVIPHGVLFRKHEQRYRQPMLENDLVEAIVGLPENLFQNNSIP SAILVLNTDKPADREGEVQFIHAADEAFYEELSNQNELTDDGLDHIVENFDDWTTEERVSRTVGIEEIEENDFNL NIALYVDTTEPEEDIDVNEELAELRELQAEREEIESRMTEHMEALQYE Halobacterium sp. NRC-1 NYSGXRC-6044l SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1287 ICEDB: T1241 GENBANK NP_273871.1 MMTEMQQRAQLHRQIWKIADEVRGAVDGWDFKQYVLGTLFYRFISENFTDYMQAGDSSIDYAAMPDSIITPEIKDD AVKVKGYFIYPGQLFCNIAAEAHQNEELNTKLKEIFTAIESSASGYPSEQDIKGLFDDFDTTSSRLGSTVADKNK RLAAVLKGVAELDFGNFENHHIDLFGDAYEYLISNYAANAGKSGGEFFTPQSVSKLIARLAVHGQEKVNKIYDPA CGSGSLLLQAKKQFDEHIIEEGFFGQEINHTTYNLARMNMFLHNVNYNQFHIELGDTLTNPKLKDSKPFDAIVSN PPYSINWIGSDDPTLINDDRFAPAGVLAPKSKADFAFILHALNYLSGRGRAAIVSFPGIFYRGGAEQKIRQYLVE GNYVETVIALAPNLFYGTGIAVNILVLSKHKDNTDIQFIDASGFFKKETNNNVLIEEHIAEIVKLFADKADVPHI AQNAAQQTVKDNGYNLAVSSYVEAEDTREIIDIKQLNAEIGETVAKIERLRREIDEVIAEIEA Neisseria meningitidis NYSGXRC-6044m SGX Pharmaceuticals 2003-01-30 active Selected HI1287 MSFNKESQQRQELHQKIWAIADNVRGAVDGWDFKQYILGILFYRFISENMSDYFDRAEHEAGDPDFRYADLSDEEA EEDFKPDTVEEKGFFILPSQLFENIVKTASTNENLNTDLAKIFKKIEESAIGKDSEHAIKGLFDDVDTTSNRLGG SVKEKNKRLSDILTGIAGLDFGTFEENDIDAFGDAYEYLISNYASNAGKSGGEFFTPQTVSKLLAQLVMVGKEHI NKVYDPTCGSGSLLLQMKKQFETHILEEGFFGQEINMTNYNLARMNMFLHNINYNNFDIRRGDTLLNPQHLYERP FDAIVSNPPYSIKWIGDADPTLINDERFAPAGKLAPKSKADFAFIMHSLSHLSNKGRAAIVCFPGIFYRGGAEKT IRQYLIDNNFVEAVIALPDNLFYGTSIATYILVLAKNKPEDKTLFIDASSDEKSTVSGKNKFYETVTNGKILNPK NIEAIVELFKNKKDVDYEAKLVDNNLIAEENDYNLSVSTYVEKRDTREIINIDELNKEIAETVKKIDHLRSEIDK IVEELSHD Streptococcus mutans NYSGXRC-6044n SGX Pharmaceuticals 2003-01-30 active Selected HI1287 VFGDAYEYLMSMYAANAGKSGGEFFTPQEVSELLVELTLIDFNNENKDVRRKIGKVYDPCCGSGSLLLKYAKLNEG VKFYGQEINLTTYNLARINMFLHNIGYDKFDIKLGDTLLDPKHNDDKPFDAIVSNPPYSTKWEGKSNPLLANDER FHVTQLAPKGKADFAFVLHILHNLSSSGTAAIVMFPGTLYRDHAEQDIRKYLVDNVNVVDSVIQLPDNLFFGTSI STCIIVLRKNKNNNDNANGILFVDASKEFVKSGIKNKLTNANIKKIVDTIRFKKEVTYFSKLVSREEVKNKNYNL SVNTYVEKEDTSEKIDIKLLNMQIKEIVAKIEKLRKEIDEIVLELEE Ureaplasma urealyticum NYSGXRC-6044o SGX Pharmaceuticals 2003-01-30 active Selected HI1287 MKTNDIVKTNNPNISLYKQLSKDFIKKENINKLKDFFILIKNKLFSIDDNSTEANIESLLKYIFEELNYSVEQQKA GQIEGVESRVDILLFENDKDKASFNNKLKEAKKNNEPIPIEDILIIAEVKRPTFSFDAKDKLKESEDQLYRYLNQ YQKHYGILSNGKVWRLYDKSKVLYGEKRYIEFNFKIEEKEEYKEQEWFVLFIYLIRKERYLKTSNVIEVEKEQIA KEKEIIQKTLKEILYERPDDSIVFKIAKNIYDKEFKLSGKEITQHILASILEESIIFILRIFFIAYIEDNDIFKK ILQENKLYRSSISFRYFFYDENTKKKLEYKKIITIFNLLDKGSDAIKFPVFNGGLFSEDKVKYLNNEGLLSISEI EEILVKMLFFEEKNIKDEKFVKYSRLDPKSFGELYETLLEYDLRIADTTVHRIIEDGVYLIRTEEELENKKVNKI ATYLKGNIYLTSRSLDRKKSGAYYTPDDLTDFMVISSIEEQLKTKSPLDIKIIDNSCGSGHFLISCLDYLTEKVW YELDKFEDVKKELDEEYRVIIEESEEYDVQDSISKELVLKRMLLKCIYGVDINPISVEITMLSLWINTFIFGTPL SFIEHHIKAGNALLGYTKDEFFDIVKKKFESGFSLFKKRIKEIITILEDIYQKIKGINDTTKEDIEKSKKIYKEY EESKDIDNLRIIFSLIKLYSLSFDKSLNMEFSDIASVISLIENILGNKTSSEDKEKIEKIRKLSSYYKFFHYGIE FPDIQEGFDIVIGNPPWEKTKFNETEFFSKHIPNYRKLGIKEQNIIKQEILSKDNHPLSIEYNEEKNSIIAINNI YKFDFKCFTSGGDPNLFRYFVTFNLKLIKEKGNLTYLVPSAIWNESSSRILRKHIFARYKLNYIYQFENKKRFKD VHSSFKFAIFQLSNIKESTSSFKAKFMIQSSDNILKEITRDLKDSKDDAYKGIELNINQIKKLSPIQESIIEFKD NEEFTLINKMFSKFSALGEGYIDFKKGLDPSIKNRKSLLKECNNKNLIFLYSGANIHQFNSRFFEDKDAKESSKL LWIDKEDLEKVLTKDNQYQTERVFYRAIASNTNERTMISTLSPGNCYCVNSIYINDEKTPISLYKKLFIISIFNS FVFDFLLRRFVDSNVLKSCLYQCPMPQPEEKEILSNPLYLNLAKNTSLLIAKNDPENFKYLLYLEYFKFDKEKVN KILKLDKEDEFFKEKENENNFIIASLYSLAKEDFITLLGDFKALKNKKKGEDYISSLIKGYDNYLLNNKIFYHK Borrelia burgdorferi NYSGXRC-6045a SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1314 MKVYKSFLIATASLFLFACSSFQNDDYAMNYKGQIGEPIMAIAMLSEQQHEWAGTPYVLGGVSRRGVDCSGFVQKT FFDRFNLRLPRSTVEQANYGKHVRKEDIQTGDLIFFKTGRGPNGYHVGIYVKEDKFLHASTRGGVVYSSMNNPYW SKAFWQVRRI Haemophilus influenzae NYSGXRC-6045b SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1314 MRFCLILITALFLAGCSHHKAPPPNARLSDSITVIAGLNDQLQSWHGTPYRYGGMTRRGVDCSGFVVVTMRDRFDL QLPRETKEQASIGTQIDKDELLPGDLVFFKTGSGQNGLHVGIYDTNNQFIHASTSKGVMRSSLDNVYWQKNFWQA RRI Escherichia coli O157:H7 NYSGXRC-6045d SGX Pharmaceuticals 2003-01-30 active Selected HI1314 VNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAKNLLGYQYKYGGETPKEGFDPSGLIQYVFSKAD IHLPRSVNDQYKIGTAVKPENLKPGDILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGT YIGARRIAADPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQWAVGEKVAP QNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYWKSKMTGIRRFDNLTIPKENPIVSEA TLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKAAGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIY IGNGQVVHVTLSNGVTITNMNTSTYWKDKYAGSIRVQ Bacillus subtilis NYSGXRC-6045e SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1314 ICEDB: T1260 GENBANK NP_370924.1 MKLKITVICSVVFSLFFFLLLFLVIFFADDTDSGENNKDSSIPQGGVTVSPEVLAHRPLIEKYGKEYGIEDYVSYI LAIMQVESGGTAEDVMQSSESLGLPPNSLSTEESIKQGVKYFSELLTSAEQQGVDIDSVIQSYNYGGGFLNYVRS HGKKYTYELAEQFSKEKSGGQKADYPNPIAIPVNGGWRYNYGNQFYVQLVSQYLTDTSPTEFDDETVQVIMDEAL KYEGFPYVFGGASPTTSFDCSGLIQWVYDKAGISLPRVAQDQYDATQEISMEEAQAGDLIFFHSTYNAGTYVTHV AIYLEGNRFYHAGDPIGYGDLSSRYWQDHLIGARRVIHN Staphylococcus aureus NYSGXRC-6045f SGX Pharmaceuticals 2004-11-12 active Selected Cloned Expressed Soluble Purified HI1314 ICEDB: T1252 GENBANK NP_815559.1 MNLKELSVISLTMLMLSFMGILMCVSLLFGEDSEGSGTSGISPGGNSVSEEVLKHRSMVEKYAKESDILDYVPILL AIIQVESGGTMEDVMQSSESAGLPPNSLSTEASIKQGCIYFASLVKSSKELGCDQDSIIQAYNYGGGYLNYVAKN GKKHSFTLAESFSKEKSGGQKVDYPNPIAIKENGGWRYNYGNMFYCLLVKQYLTTTQFDDKTVQGIFDEAFKYEG TAYVFGGSSPATGFDCSGLTQWCYAKVGLKLPRVAQDQYDVMTHIDLKDAKPGDLIFFHSTYDAGTYVTHVGIYA GENRMFHAGNPVGWTNLTESYWQQHLIGAGRYN Enterococcus faecalis NYSGXRC-6045g SGX Pharmaceuticals 2003-01-30 active Selected HI1314 GENBANK NP_216706.1 LRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQR AADQKLADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMAR FKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPVPAVA AIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYAWGGAAPGGFDCS GLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSS GPIYDARRY Mycobacterium tuberculosis NYSGXRC-6045h SGX Pharmaceuticals 2004-11-11 active Selected HI1314 MRFWLLVITALFLAGCSTHRAPAPNARLSDSITVIAGLNDQLQSWRGTPYRYGGMSRRGVDCSGFVVVTMRDKFDL QLPRDTREQSKIGTRIDKDELLPGDLVFFKTGSGESGLHVGIYDTNNEFIHASTSRGVMRSSLDNVYWRKNFWQA RRI Salmonella typhimurium NYSGXRC-6045i SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1314 MPNRHGSPRSSTRWAGLAIIALACLLSACSSTPTRSLTSRDTSGQRTHGAAINDPSAGLEEISIEAMALVGTPYRY GGNTPDSGFDCSGLVRYVVQRAASVNLPRTAAEMGTRGFALERRDVASGDLVFFNTTGRPNSHVGIYVGQNRFVH APATGGTVRLEDMSKRYWASRYMGARRVVAVSNLPDLPASPAAATQSIAAGAAAPATAPAHANDDDPLGTLARAR GTESSPLMSTRNAAPVVVPPADDDPIARFATQ Ralstonia solanacearum NYSGXRC-6045j SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1314 GENBANK NP_274993.1 MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQP VLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGF MQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSL SHKYWSGKYAFARRVKKNDPSRFLN Neisseria meningitidis NYSGXRC-6045k SGX Pharmaceuticals 2003-01-30 active Selected HI1314 MRHIFFIITIIFFISGCSFYQNLNYRPSYNTNKEARLKVIANEWKKTPYVLGGTSKKGADCSGFTQSALAQLNIRI PRTTKTQLGSGRKVSKSKLQTGDLVFFKTGRGPNGMHVGIYMSKGKFIHLSTKDGVKEVELNSSYWKARYIGARR Y Campylobacter jejuni NYSGXRC-6045l SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1314 GENBANK NP_231177.1 MLTVKQTFSLLILGFLVGCTATPPSEPDTSVSEPNSSNLPLANFSSVFTEWRGVPYRLGGNSKNGIDCSAFVQIAY RDAWQRDLPRTTQSQAQTGQKIAYEHAQYGDLVFFKTSRTNIHVGVYLGDKQFMHASTSKGVIISRMDNPYWASK FWHFRRIENPPLLSN Vibrio cholerae NYSGXRC-6045n SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1314 VPMRKEQQSRPDLRVLKSLMVCATIAASLILHSPSLMAAEEATGATSTAPSACSINPSEKLKNLFTEVKQYLGIRY RFGGDTPSGFDCSGFVRFMFNKEFNVNLPRSSREMATIGTRIDRNELRPGDLVFFKNAEDRINHVGIFVGNDTFV HSSLSKGITRDTLNESYYSKRFATGVRILDIQGNRIPDDFNNLFDESNNGNSPS Chlorobium tepidum NYSGXRC-6045o SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1314 VTAMLSMACRRAVRAGAHCDEGGHVKAFDYPDSMNNKPVPIVLRRTSIGLILFILPAMLIGCSRVPVKTQPKPASV NVWPLTTPANPEAANEVVMRALSLVGTPYRFGGNTPESGFDCSGLVSYVYRDALDLRLPRTSYELAAVQGPKIDA EQLTTGDLVFFGSARSVTHVGIYLSEGRFVHAPSSGGTVRLDRLDTPYWRDHYTGAKRVLR Xylella fastidiosa NYSGXRC-6046b SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1317 ICEDB: T1263, T1266 GENBANK YP_001458559.1 MKLKDCVMIKKIFALPVIEQISPVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKN GVAIRGGVPVCWPWFGPAAQQGLPAHGFARNLPWTLKSHHEDADGVALTFELTQSEETKKFWPHDFTLLAHFRVG KTCEIDLESHGEFETTSALHTYFNVGDIAKVSVSGLGDRFIDKVNDAKENVLTDGIQTFPDRTDRVYLNPQDCSV INDEALNRIIAVGHQHHLNVVGWNPGPALSISMGDMPDDGYKTFVCVETAYASETQKVTKEKPAHLAQSIRVAKR Escherichia coli NYSGXRC-6046c SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1317 GENBANK NP_254109.1 VILLPSIRLPETAMNTDSPINRVEQVQVDDLACWRIHTAHGEALIAQQGAQLLSYQPHEQPPLVWLSDEAGYRRGQ SVRGGVPVCWPWFGPLERNPQEVRGQVEDGLKAPAHGLVRAVDWKIDDIAEEDGDLCVSFRLDAPDGLPGWPHPA ALRMLFRFGERLTLRLTSENLGSKPLVLSQALHTYFAVSDSREIAIEGLEGARYIETLENWEERTQHGAVRVKGE LDRIYLGLERDLLIKDPRWERSIHLHALDSRSAVVWNPWVDKSRRLSQFADDAWQQMLCIETGRVWDDLMVVAPG RSESFGVQIWSEPLKRP Pseudomonas aeruginosa NYSGXRC-6046d SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1317 GENBANK NP_460255.1 MINKIFALPVIEQLTPVLSRRQLDDLDLIVVDHPQVKASFALQGAHLLSWKPVGEEEVLWLSNNTPFKTGVALRGG VPICWPWFGPAAQQGLPSHGFARNLPWALKAHNEDDNGVMLTFELQSSEATRKYWPHDFTLLARFKVGKTCEIEL EAHGEFATTSALHSYFNVGDIANVKVSGLGDRFIDKVNDAKEGVLTDGIQTFPDRTDRVYLNPEACSVIHDATLN RTIDVVHHHHLNVVGWNPGPALSVSMGDMPDDGYKTFVCVETVYATAPQQATEEKPSRLAQTICVAKR Salmonella typhimurium NYSGXRC-6046e SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1317 MFDIPGLSTGDFHGFPSLLIQTPFSHAAISLFGGQLLSFVPSGGEEVIWLSPLVQPPPTAIRGGIPICWPYFGRQG QRDTMPAHGFVRTVPWQQVESCQENDGSLFLVLAPPPLKHLGLHLRMTLRIGRTLEQELATENISHAPISFTQAL HNYFRVSNALQVTVQGLDGVEYLDKFEGYTQRHRQQGHWTLQDPRDPGRADRIYVDTSGHYVLVDPLFSRRIVLT TEGSHSLVVWNPGHAGASNMIDVADGWRDYLCLEPANAGPDEIELLPGARHVLRQSIAIAPL Xylella fastidiosa NYSGXRC-6047a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1364 GENBANK NP_439515.1 MDKLNAISIFCKVIETQSFTLAAKQQNISVAMASKLVSQLEEHLKTRLLQRTTRKIMPTEAGMMYYQRCQGILLDL DEADSSITQLTSSLQGNLLISVPRDFGLLFIAPNLPTFMAKHPHLHIEVEFNDKKIDLLSEGYDLALRIGYMEDS SLVSRKIGTTTVHFAASPNYLETNGIPQTPDDLEHHNGLLYKNAMNQVNWVGSRINQTQRFKIQSKVVSNSGFAL LNMAKAGLGIANLPKFILGRAFEKGELIEILPEYKQQKLEIHVVYPNRRHLPIKVTGISLNF Haemophilus influenzae NYSGXRC-6047b SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1364 GENBANK NP_252320.1 MNRWEGLDEFVAVAETGQFTAAAERMGVSSSHISRQVARLEERLQTRLLYRSTRRVSLSEAGQTFLQHCQRLQDAR DEALRAVSDLSAEPKGLLRMTCAVAYGERFIVPLVNAFMADYPQLRVDIELSNRQLDLLHEGFDLAIRLGRLSDS RLVATRLAPRVMYLCATPEYLRRHGTPQSPAELGQFNCLIGSSDLWSFLEDGRETQHRVQGNWRCNSGQAVLDAA LRGFGLCQLPDYYVIEHLRSGRLASLLEGHQPPNTAVWALYPQQRHLSPKVRQLVDYLKEGLAQSHPGLAGEKNL R Pseudomonas aeruginosa NYSGXRC-6047c SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1364 MLEKIINNAICALLFRCEQQSVKEMDKIHAMQLFIKVAELESFSRAADFFALPKGSVSRQIQALEHQLGTQLLQRT TRRVKLTPEGMTYYQRAKDVLSNLNELDGLFQQDATSISGKLRIDIPPGIAKSLLLPHLSEFLYQHPGIELELSS HDRPVDILHDGFDCVIRTGALPEDGVIARPLGKLTMVNCASPHYLTRFGYPQNPDDLTSHAIVRYTPHLGVHPLG FEVASVNGVQWFKSGGMLTVNSSENYLAAGLAGLGIIQIPRIAVREALRAGRLIEVLPGYRAEPLSLSLVYPQRR ELSRRVNLFMQWLAGVMKEYLD Escherichia coli O157:H7 NYSGXRC-6047e SGX Pharmaceuticals 2003-01-30 active Selected HI1364 MRADDLILFYQVIELGSFSKVAEQNGLTNSVVSKRLARLEEELGVQLLYRTTRKLTLTEAGKALLHGAKNVKQATQ EALDAVVGFGENVSGHIKMSVPTISGDLILADAVAEFCNLHPGLTVDMSLDNRFVDLVEGGYDLVIRTGYLEDSS LIARHILDSQWVVCASPAYIARNGKPLKPEDLARHNCLQYAYQTTGATDWEFKGAKGNYIVKVSGTFSTDNATAL RKAALGGHGIAYVPRCLVYHDFRNGELVDVFPEQVGKKLGIYAVYPFTRQPPNKVRLLIEHIRARYLAISHYF Vibrio cholerae NYSGXRC-6047f SGX Pharmaceuticals 2003-01-30 active Selected HI1364 MKATSEELAIFVAVVESGSFSRAAEQLGQANSAVSRAVKKLEMKLGVSLLNRTTRQLSLTEEGERYFRRVQQILQE MAAAETEIMESRNTPRGLLRIDAATPVMLHFLMPLIKPFRERYPEITLSLVSSETFINLIERKVDVAIRAGTLTD SSLRARPLFTSYRKIIASPDYIARFGKPETVEELKRHLCLGFSEPVSLNTWPIACSDGQLHEIKCGISSNSGETL KQLCLNGNGIACLSDYMIDKEIARGELVELLADKRLPVEMPFSAVYYSDRAVSTRIRAFIDFLSEYIRTAPAGAV KEG Salmonella typhimurium NYSGXRC-6047g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1364 MARRNLNDLLYFVTIAREGSFTRAAAHLGVTQSALSQAINGLEARLQIRLLTRTTRSVSPTAAGERLLNAIGHRFD EIESELDELTELRDKPAGTVRITCGDHILRTTILPKLTPLLREYPDINIEFDVNYGFRDIVADRFDAGVRMGDTI DKDMIAVPIGPPLRMAIAASPEYFASHPVPKKPHDLLNHNCINMRMQTSGGIYVWDFMRRGKQLNVRVDGQLIFN TTPNMVDAALVGLGIAALPEEEFAPHIEEGRLMRVLEDWCEPFSGYFLYYPSRRQPSPAFSLVVDALRYSEGRPS KEPIGTPQEEGRAAEESSREMSW Xylella fastidiosa NYSGXRC-6047h SGX Pharmaceuticals 2003-01-30 active Selected Cloned HI1364 MSRWDGIDEFVATAEAESFSRAARRLGLSTSGVSRAVATLEERLQTRLLYRTTRRVSLTDAGRAFLARARRLIAER DEALASVGEDDGDPRGLLRMTCSTAYGERFVVPAVNRFMLSHPKLALEIDLDDAVRDIVSEGFDLAIRFGRLTDS RLIAKRLASRTRRLCAAPSYLTRAGAPRSIADLAAHTCILGAADTWPFRDGEREIAFKPQGRWRCNSGQAVLDAA LLGLGVCQLPNFYVDAAISDGRLVPLLEANRPEDEGVWAVYPHLRLLPAKVRLLVEHLEEALSGQG Caulobacter crescentus NYSGXRC-6048a SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble Purified HI1375 ICEDB: T1278 GENBANK NP_439527.1 MKIFTSKKGQLSQLKQQKFKLEKDIQRLFEENLTLLSGYIFIRSEFSIKNSRIDTLAFDPETQAFVIIEYKRQQNS SVVDQGISYLNLMLEYKADFIVEYNEKQKVPLKRNDVDWSQSKVIFVSPAFNDFQIQATNFKDLPIELWEVNRFD NDIITLNIINKSKSAPNIKAVSNEKREEFSILKEIKVYQESDHLADKTDFIQELYEDFKQGILNLDPDIEINTRK LYIAFKKDRNIADIRIQQKNLKIWINLPYGELDDPKNLAKNVSNTGHWGNGDYEITIESTQYLEYIMSLIKQAIK D Haemophilus influenzae NYSGXRC-6048b SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1375 MKATEARLLDFLKRSQQFVIPIYQRTYSWTEQQCRQLWDDIIRAGKRDDISAHFIGSVVYIEQGLYQVSGISPLLV IDGQQRLTTAMLLIEALSRHLGEDEVFDGFSAMKLRNYYLLNPYESGEKGFKLLLTETDKDSLLALIKQRPMPEN YSHRIMENFTFFDEQIAKLGDDLIPLCRGLAKLLIVDVALNRGQDNPQLIFESMNSTGKALSQADLVRNFILMGL EPEHQTRLYEDHWRPMEVACGQQGYSEYFDSFMRHYLTVKTGEIPRTDEVYEAFKLHARSQSVAEKGVDRLVEDI HIYAEYYCAMALGKESDKSLATAFQDLRELKVDVAYPFLLALYHDYKNDDLSHEDFLSIIRLIESYVFRRAVCAI PTNSLNKTFATFYKVINKEKYLESIQVHFLNLPSYRRFPNDDEFKRELKVRDLYNFRSRSYWLRRLENDKRRERV EEFTIEHIMPQNENLSAKWREELGSDWQRIHKELLHTLGNLTLTRYNSRYSDRPFAEKRDIEDGFKHSPLYLNIG LGQCEKWDEAAIHARADRLAELAVQVWQAPSLPEEVLAVYRGQPENKTSYSLSDYPFLADGSHSRVLFDHLRDEI MRLDAGITQEVLKLYIAFKAETNFVDVVPQKSRLRLSLNMQFHELVDPKGIAKDVTNVGRWGNGDVEIGFSDLAQ LPYIMGLIRQAFEKQMESALV Escherichia coli O157:H7 NYSGXRC-6048c SGX Pharmaceuticals 2003-01-30 active Selected HI1375 MNGHFIGSILYVLDSNTHSNNTLLIIDGQQRLTTITLLLIALRNHLSEEVEILEKFSRKEIESYLINSNKDGDKKF RLILSESDKDTLLSLIDKNKRKPSEPSVKIVENFELFEKWISENTDKLETIFKGLKKLMIVWISLDKGKDDPQLI FESMNSKDIELTQTDLIRNYIVMETEVEKQEDFYNQYWRAMEERFEQNETLFNRFVRHYLTIKIGKIPNEKRVYE AFKDYRQKKGIEIEDLLKDLQKYCGYFCQIAFKKEDDKDLNKALSFLVNLEMDVIYPLLLELYSDYKDGVLSKQD FIPIIYLIESYICRRAVCGLGTNSLNKVFPSFTKHIQKDEYFKSLKAHFVCLTEKQRFPNNDEFKKLFITIDFYK FKKNKYFLERLENFDTKEPVDTQKCNIEHIMPQTLTPEWQRDLGENFQAIHEKYLHTIGNLTLTGYNSKYSNNSF QEKRDMEKGFKQSSLKLNQSLKDLESFGEKEIEKRASDLADWALKIWTYPILEAETLEEYKPKKEKKEKKEKEEY KLKKEKKVYDLSSYKFSSDSRELFDILREKIKALDERITEKFNQKYIAYKFCKISFVDIVVQEKGLKLYLKMNLN ELQDEIKEKLKIRDVSNIGRPCVGNMEVELETKENIPYCLGLIKQALEKQMGGRNRQ Helicobacter pylori NYSGXRC-6048d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1375 MKKLSLQSIGLFFAAAVLMVFLTGCENRFDLEDIPQEAEIRTRSAIGETDNGREYLGRNFYLTSSDEVVSDSRSGA ERKMLARTFNIQTGSVGSNCLGVHVMACYTDKDGTLQQIEVWVNDEYAGELDIRKAEWDFVTLKDGKTVRLRQGA NKITFLSSLPYFPEIDAIQVESARQALMKEDPQYNAFIALLKQQRNASTSKLEQEEIIRMTSESNDGLNASSHSA GRSAYDQGWNWQVTPRELSNPDGNYRHLVCVPVTYTYHRKLSLSSGTHTFMTTPIEGDSYYTVDPVMYLYKIDDP HNHTYYNDDASGLGHHAQITETLLAGEYYLVIRAYSSYYASTTTGRQGLVNVFQDGYILNSQCPIAGYSVDVDSP NTGTINYFTAYTTGIAEFFLEEKGSKKVKFFGESYFYVPPMEQMWFNDARLRLTKPSSQARYNMIISSVGAFGAY YGNCDVYGSCQQVMPGDQVANSFPNLMVNDGIYSSGGNTGVYNCASWAGGLTYGWTWGSIYESYANPELVGPYYG DPNVWSSWDAFFANNPQRYAGATVYTRENADATNGEVAVWSYNGNISGVTHFSCRGTANDHPHGYAWESKLGRQR RIFHPRDALRGQGMYSYGQVFAYYRDASKPIGPYPNPGLRKNSSQSISFEESVRRGLTVIEKVELFPVEKETFTR KSKEKGLTANNPEIRKLYDAWDKKISSRYAHISNPYVLMEIQEGKNLIAYCREKQQEALVFFINLYFNDSRETAT KAVSHYMFCVIFSEYGAEIEAIKNDWRRNQYNQKGAYIAPVPEMFVKKFAKRLFNKLL Porphyromonas gingivalis NYSGXRC-6049c SGX Pharmaceuticals 2005-04-07 active Selected Cloned Expressed Soluble Purified HI1394 ICEDB: T1284 GENBANK NP_461966.1 MQPNDITFFQRFQNDILAGRKTITIRDASESHFKAGDVLRVGRFEDDGYFCTIEVTGTSTVTLDTLNEKHAQQENM SLDELKRVIAEIYPNQTQFYVIDFKCL Salmonella typhimurium NYSGXRC-6049d SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1394 GENBANK NP_231216.1 MSISTQITFFEFLTPLVASGQKTITIRDKSESHYVPGTRVEVFTLETQRKVCEIDILAVEPLKFDEINEFHAEQEA IELPKLKALIQEIYPNIDELYVITYQLAK Vibrio cholerae NYSGXRC-6049e SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1394 ICEDB: T1283 GENBANK BAA29534.1 VEGKSLWRHSDKIQAPGEGKEVKNLKFDGRYKDDIISGKKKATIRLGRKVNLKPGEEVLIHAGGYVLGKARITRVT TKKVSELTDEDARKDGFKSREELLEALREHYKFVKPDSPATIVEFEMLSVLDKPILSADYPYEGNNPIEIAELAL EHLDNLSFEEVALLKLFLKEGSLRKAAMKLGGLNKRYKIREVLRKAYEELKKRGIMQPKI Pyrococcus horikoshii NYSGXRC-6050a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1403 GENBANK NP_439556.1 MKAFLHHLQNEAKLIISLTYCVDGEFALNEIARATLQQYGIVQLSSATNSDSETEAATSKAVKTAYDKAVEAKTTA DGKVGLNGNESINGEKTFENRIVAKRNIRISDSPHYASRGDYLNIGANNGDCWFEYKLSNQEIGTLRMHANGDLT YKRQKIYLKMDCWQAIHKRKLKVFTAKRKKR Haemophilus influenzae NYSGXRC-6050b SGX Pharmaceuticals 2004-11-11 active Selected HI1403 MDNEFYTLLTDRGMAKIASALADKKQLHLQKMAVGDGGGQYYEPIASQTKLRHEVWRGEMNTLTVAPNNPNWLIAE LVLPEDVGGWYVREVGVFDDEGELIAIGKFPESYKPLLPGGCGKQVCIRLIMEVSNTTAVTLTVDPSIVLATRDY VDTRLDEHEHSTNHPDATLTQKGFTQLSNATDSDDETKAATPKAVKAAMAEARNHTHTWNQITGVPDGTLTQKGI VKLNSATDSTSTTEAATPSAVKAAMDKANAAAPANHTHVWNQVTGVPDGTLAQKGIVKLNNATDSTSTTEAATPS AVKAAMDKASAAAPARHTHAWGQITGAPDGTLTQKGIVKLNNATDSTSTTEAATPSAVKAAYDKASAAAPANHSH YQFFTANGTFTVPDGVTQVFVEMLGGGGGGGGGGHTSNTDGLLYCSGGNAGKSGEPEIAIVPVIAGNNYPVTVGA GGASGAGGVLPNSNPTGNVVQVGQAGNSGINGGNSIFIDVVANGGAGGAGGIVQSRIPLSGFNQLDSISGGNAET TFFGKGGTGAVLSNGSNASGYGAGGGGGASVNSLNIALSGYAGGRGSSGFVKISW Salmonella typhimurium NYSGXRC-6051a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1418 UNIPROT P44189 MGKLSILSKRKYTMKNQIQFSTFNFKDLPVRVILDPKGEFWFCGTDVCHILGYTNSRKALQDHCKQGGVTKRYTPT KSADQEMTFINEPNLYRLIIKSRKPEAEPFEAWVFEEVLPQIRKTGKYQLQPQQLALPEPEKKFSFEFTEYELQQ LVWLWFAFMRGIVTFQHIEKAFKALGSNMSGDIYGQAYEYLSVYAQQTKS Haemophilus influenzae NYSGXRC-6051b SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1418 GENBANK NP_287306.1 MKSIAKAQNDFTIFKFGDSEIRVINKCGEPWFVAKDVCDALALTNSRKALTALDDDEKGVTLSYTLGGEQNLSIVS ESGMYTLVLRCRDAVNKGSVPHKFRKWVTAEVLPSIRKHGEYVKGKKTTVEERTPLRDAVNMLVGKKGLRNDDAY NMVHQRFGIDSIDELSIEQIPLAVEYIHRVVLEGEFIGKQEKSTNELSAKEANSLVWLWDYANRSQALFRELYPA LKQIQSNYSGRCYDYGHEFSYVIGMARDVLINHTRDVDINEPDGPTNLSAWMRLKNKELPPSPHHY Escherichia coli O157:H7 NYSGXRC-6051c SGX Pharmaceuticals 2003-06-06 active Selected Cloned Expressed Soluble Purified HI1418 ICEDB: T1290 GENBANK NP_371379.1 MQALQTFNFEELPVRTLEVDGEPYFIGKDVADILGYANGRDALSKHVDEDDKKVLTSRNTTLENLPNRGLTAVNES GLYSLIFSSKLESAKRFKRWVTSDVLPAIRKYGIYATDNVIEQTLKDPDYIITVLTEYKKEKEQNLLLQQEIGEL KPKADYVDEILKSTGTLATTQIAADYGISAQKLNKLLHEARLQRKVNKQWVLYSEHMGKSYTDSDTITIVRSDGR EDTVLQTRWTQKGRLKIHEIMTEFGYEANLGGA Staphylococcus aureus NYSGXRC-6051d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1418 MNASSEFTLQFESHAVRVQVDEAGTPWFNANDICTAVELLNPCAALAQHVGARNVSKRKIIDTIGRTQRANYLNEP GVLTLLIGSTKEAAKRLRRWLISEALPAAAVQKAGQHSVPQHHAPSISTPFQPTEDHTMNAITPFQFESHAVRTV VDDHGEVWFVGKDVADVLGYTNHNKALGDHCKGVPKRYPLQTPGGIQEIRIISEPDMLRLIVSSKLPAAERFERW VTSEVLPTIHKTGNRPALDHSTHSANAITPFQFESKDVRIQLDEASAPWFNANDVCSILEFGNPRQAIESHVDVE DVQKLDATDNLGRTRQTNHINESGLYALIMGSTKPAAKRFKRWVTSEVLPTLRKTGTYSTPGALPTLPGPTQDRI AALLLIGQYISTVPGVKPGIAAAATLACIKSNTNLTTEEIRRALPALRDPLCMLNATQLGKQLHCSAKAVNQLLA SRGLQFRNERDDWELTEAGRVWGEAIPYSRNGHSSYQILWNPTVVDSLKVAA Xylella fastidiosa NYSGXRC-6051e SGX Pharmaceuticals 2003-01-30 active Selected HI1418 MELQVFTNEQFGEVRTATINNQIYFNLNDCCQILELSNPRKTIERLNKDGVTTSDIIDSLGRTQQANFINESNFYK LVFQSRKPEAEKFADWVTSEVLPSIRKHGAYMTEQTLEQALTSPDFLIRLANELKEEKERSRQLEAEKSILSVEN MVMKPKADYFDDLVDRNLLTSFRETAKQLKVKERRFIQFLLDKKYVYRDKKGKLMPFADKNNGLFEVKESVNEKT NWAGTQTLITPKGRETFRLLFI Streptococcus pyogenes NYSGXRC-6052c SGX Pharmaceuticals 2003-01-30 active Selected HI1422 MNQLINVTLNENQEPVVSGRDLHKVLEIKTQYTKWLERMSEYGFVENEDFMAISQKRLTAQGNQTEYTDHVLKLDM AKEIAMLQRNEKSKEVRKYFIQVEKDFNSPEKIMARALLMADKKVHKLEAQIEADRPKVLFADAVSASHTSILVG ELAKLLKQNGVNIGATRLFTWLRKHGYLIKRNGRDWNMPTQKSVELGLIRVKETSITHSDGHITVSKTPLVTGKG QQYFINKFLNQEYLPV Streptococcus pyogenes NYSGXRC-6052d SGX Pharmaceuticals 2003-01-30 active Selected HI1422 MSNLQVIANEMLPVLENEQGEKFVDARMLHEKLLVNTRFNDWIYRMIGNYGYENGLDFYSTLSKTNGRPSTNYFLT LDTAKELAMVQNNEMGRAIRKYFIEVEKQARKLATEYPAFSYMIEDPVARAKKWIEEQQEKQEVLKKLEEQKPKV VFAEAVQTSENTILVKDLATILKQKGLDIGQNRLFEWLRGSGYLLSKGAYYNKPSQKAMNLGLFEQKTHIHTDRN GLMKTTYTPQVTGKGQVYLLNKLLEEHNQVII Listeria monocytogenes NYSGXRC-6053a SGX Pharmaceuticals 2003-01-30 active Selected HI1436 MRNQTKQHLEQLQITMQQLNLWQTMPPAAEAFLSEEPFSIDTMSAEEWLQWVFIPRMQALLESSALPNKIAISPYI EEAMKEFNELQQLLTPLVALEELNNNEC Haemophilus influenzae NYSGXRC-6053b SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1436 GENBANK NP_253386.1 MDRRVYALADQLLLIERELRALGWWSESSPAPEALASPEPFCVDTLALEQWLQWIFLPRMKLILESDSALPQASGI LAIAEVAYAQRGEEVAGLLAALGEFDRLIGGPS Pseudomonas aeruginosa NYSGXRC-6053c SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1436 ICEDB: T1297 GENBANK NP_417272.1 MTTHDRVRLQLQALEALLREHQHWRNDEPQPHQFNSTQPFFMDTMEPLEWLQWVLIPRMHDLLDNKQPLPGAFAVA PYYEMALATDHPQRALILAELEKLDALFADDAS Escherichia coli NYSGXRC-6053d SGX Pharmaceuticals 2004-11-11 active Selected HI1436 MTTHDRVRQQLHALETLLREHRHWRLDAPQAHLFTSTQPFFMDTMEPLEWLQWVLIPRMHTLLDNAQPLPEAFAVA PYYEMALAADHPQREAILAVLQDLDALFVRDKS Salmonella typhi NYSGXRC-6053e SGX Pharmaceuticals 2004-11-11 active Selected HI1436 MQFNAVLVKLLDELEVRLRAAQLWQATPPSSQALVSQEPFAVDTLLPHEWLQWIFLPKMQQAIAQNAVPRGFALEP YFSEVWQGEARYQAVLAVIQQIDKVCQ Vibrio cholerae NYSGXRC-6054a SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1476 ICEDB: T1303 GENBANK NP_439627.1 MQYQNQDNFPERIEYLVDKLNGPSEFARKTGVTLSTITRWRKGEADPSRSNLVKIAEVTGVSIEWLATGKIKEEKT TEEKPAGSLVSRAFERMQAMLEEGVSMIDSYSSINVSAGFGSFNEGITQPDGQEPYSDELLTSLGVKADNCAVFW ANGNSMLPTINNYDQMLVDLSRKEIQGDRIYLVQNGESVWVKRVKMEWDGISLISDNKEEYPPISITGENAQNLQ IIGQVVHIGHSLI Haemophilus influenzae NYSGXRC-6054b SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1476 GENBANK NP_249302.1 MDKSTQIPPDSFAARLKQAMAMRNLKQETLAEAAGVSQNTIHKLTSGKAQSTRKLIEIAAALGVSPVWLQTGEGAP AARSAVSVADGSPLVLEPLHPWDSDTPLDEDEVELPLYKEVEMSAGAGRTAVREIEGRKLRFSYATLRASGVDPS AAICAQLTGNSMEPLIMDGSTIGVDTATTHITDGEIYALEHDGMLRVKFVYRLPGGGIRLRSFNREEYPDEEYSP EDMRSRQISMIGWVFWWSTVRHRRGPSLVR Pseudomonas aeruginosa NYSGXRC-6054c SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1476 MHDMKIGSRIRAERENQGISRTELAKFAGIATSTLSDLELGHSRSTTALHKIAERLGVSAQWLETGRGEKSTDTFP APISNNSLGYVRVQQMGEAGMGDGRENEDFPEIVRTVEYSEAFLRSLLGFLPPPGRLVLVTGKGDSMTPTIAPGE VVLVDTGTHTFEGDGLYLVNVGHGHQIKRLQDRGRLFVVSDNHLMPSFEFPEEGIIGGKVYLINKIERVN Xylella fastidiosa NYSGXRC-6054e SGX Pharmaceuticals 2003-01-30 active Selected HI1476 MRKAPQGSFPADGKEPIIERIFRLVERYPSRNAAARAWGINEGTLKNYYNRRDYAPIPRPYQLKKIAESENVTLEW LMTGEGDVELKDSKEPKKENADNVDAQILMFLSFLKPQEKQQVADVLGRKGAEQLLILLDEHIQELHALVGVRRA IALSLGNLPDEKVREIYALSEAKGDHLNLPQKAASA Shigella flexneri NYSGXRC-6054f SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1476 GENBANK NP_142530.1 MRVSDILISLLLVGIVVPSVVGFLMGRPVFVSYAYSDSMVPTINRWDVFFINPLSKGEVGDIIVFNLSGRWTVHRV YAITEEGYITKGDNNVATDQQDGKNPPVPRDQVIGKVITLGGKPVKIPKLGMYLRSSNSQYLAITLVVIGGIMLG TGNKVKRKKRRRGKVIDTGTLYLMLSALLAFGIVFAGSTLWGEISVTYVSTLGGGQREGWYLPGSVVEENVTIKN YARIPMVFIVKGKIVNDTIFKLGGGEERVIKGIIHVPEETRVYTERVNVYSYYPLLPTGTIERAYSINPYLPLII EGLLVFLALAMIKPFLGEPEYISLGRFWK Pyrococcus horikoshii NYSGXRC-6055b SGX Pharmaceuticals 2003-01-30 active Selected HI1505 VGDGIRQAMLARAGFENVEKDNAYNGMTLREWARMSLTERGIGVASYNPMQMVGLALTHSTSDFGNILLDVSNKGL IQGWEESEETFQKWTRKGRLSDFKTAYRVGMGGFGSLRQVREGAEYKYITTSDRKETIALATYGEIFSITRQAII NDDLNMLVDVPMKMGRAAKATIGDLVYKVLTDNPKLSDGKALFHADHKNIATGGISVSGLDAARQMRLQKEGDRA LNIRPAFMLVPVALETVANQTIKSASVKGADANAGVINPIQNFAEVIAEARLDAADPKTWYLAAAQGTDTIEVAW LDGVDTPYIDQQEGFTTDGIATKIRIDAGVAPLDWRGLVRSSVA Escherichia coli O157:H7 NYSGXRC-6055c SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1505 MRVAVVGFGQTPFRTKRKDKTHPELAFEAINAALDHAGLEMKDVEAVAYGCMDPFDGIYCPERWDATAAGLEKPIM KISTGGTTGMTTALAAYEHVASGLFDLVMAVCVQRVGECVDAQPVLNTAVDPIYERHSGLGAIHVASFQATAYMA KYGATEEDLAWVSVKDHKNALKNPYAHIKMDVSVEGVLKSRVVCSPLKLLECCPRSDGAAAVIFASEDVARKIRD NPAWVVAETTISDSYYLGDRPSFAEWDSLAIAGRRLFKAAGIEPDEIDVAELYSPFTIQEILELEALGFAKKGEG KNFAREGVTFVDGDFPTNPSGGVLCTNPIGATGLVRFGEAALQVMNEAKNQVDGAEVALAHAWGGTLQFHTLALL SSRR Archaeoglobus fulgidus NYSGXRC-6056a SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1511 ICEDB: T1312 GENBANK NP_439661.1 MSISFNNIPSALRVPLTYIEFDNTKAVSGPPTALHKVLMLGTKLATGSAKAGEAVRVSAYAQAKTLFGRGSQLAEM VKTFKAHNSTLDLWVLPLDEAPSGAKATGSVQITGTATQAGTFSLMIAGNNYKTAVTSGDTADVVAGKLQKLIAA DQDVPVVATVAGNTITLTCRFKGETGNEIDLRCNYYSGEAFPEGLKATITDMKNGAVNPDMSVAITGLGAEWWNY IINPFTDTESLNLLRADLVKRWGPLKQIDGICFMAKRGTHAEVTTFAEQRNDYLFSLLATHKAPQPAYLWASAYA AVVAGSLAIDPARPVQTLVMDLLPPSMSDRWDLPERNTLLYSGVSTYTVNAGSQPQVEAAITMYRKNAFGDNDES YLYVETIATLSYLRYAIRSRITQKFPRHKLANDGTRIGPGQAIVTPKIIRNELLALFTELEFAGLVEDFEQFNQT LFVERDSNNPCRVNVLSNENLVNQFRIYAHAIQFIL Haemophilus influenzae NYSGXRC-6056b SGX Pharmaceuticals 2003-01-06 active Selected HI1511 VPASAVGALGEASYTVTANVTDSAGNSNSASHNVQVNTALPGVTINPVATDDIINAAESGNAQTIGQVTGAAAGDT VTVTLGGKTYTATVQGNLSWSVDVPAADIQAIGNGNLTVNASVTNGVGNTGSGSRDITIDANLPGLRVDTVAGDD VVNSIEHAQALVITGSSSGLAAGAALTVVINTVTYAATVLADGTWSVGVPAADVSNWPAGTVNITVSGTNTAGTT STITHPVTVDLAAVAISINTVSGDDVINAAEKGADLTLSGSTSGVEVGQTVTVTFGGKTYTATVAGDGSWTTTVP AADLSVLRDGDATVQASVSTINGNTASATHAYSVDATAPTLAINTIATDDILNAAEAGNPLTISGSSTAEAGQTV TVTLNGVTYSGSVQADGSWSVSLPTADLSNLTASQYTVSASVSDKAGNPASANHGLAVDLTVPVLTINTVSGDDI INAAEHGQALVISGSSTGGEAGDVITVTLNSKTYTTMLDASGNWSVGVPAADVTALGSGPQTITAAITDAAGNSD DASRTVTVNLAAPTIGINTIATDDVIKATEKGADLQITGTSNQPAGTTITVTLNGQNYTATTDSNGWSATVPASA VSALGEANYTVTANVTDTAGNSNSASHNVLVNSALPAVTINAVATDDIINAAESGNAQTISGQVTGAAQGDTVTV TLGGNTYTATVQSNLSWSVDVPAADIQALGNGDLTVNASVTNGVGNTGSGSRDITIDANLPGLRVDTVAGDDVIN SIEHNQALVITGSSSGLTAGTALTVEINNVTYGATVLADGTWSLGVPAVDVSNWPAGTVNITVSGTNSAGTTSTI THPVTVDLAGVAITINTLSGDDVINAVEKGETLVVSGSTSGVEAGQTVTVTFGGKNYTTTVEANGSWTVNVPPAD LAALPDGAGNVQASVSNINGNSAQADRAYSVDATAPLVTINTIASDDILNVSEAGAGITISGTTTAQAGQTLTVT LNNNTYQTTVLADGTWSVNVPAADLSGLTASSYTVTATVSDKAGNPASADHALVVDITAPDLTINTVAGDDIINA IEHGQALVVSGTSTGAAAGDVVTVTLNGKNYTTTLDASGNWSVGIPAADVTALATGSQTITASLSDRAGNSDSTT HDVTVDLSGPTLTINTVSGDDIINAAEIVVAQTISGQVTGTAVAGNTVIVTIGGNQYNATVQSDLSWSVSVPANV LQALGNGELTISASLTNSANNTGTATHDIVIDANLPGLRVDTVAGDDVINSIEHTQALVITGSSSGLAAGAALTV VINSVTYGATVLADGSWSVGVPVADVTNWPAGTVNIAVSGTNTAGTTTSISHPVTVDLAAVAITINTLSTDDVIN AAEKGSDLQLSGTTSGVEAGQTITVIFGGKSYTTTVAADNTWGLTIPAVDVATLPDGAANVQASVSNVAGNSTQA THAYSVDATAPSVTINTIATDDILNAAEAGSALTISGTSTAEAGQTVTVTLNGVNYSGNVQADGSWSVSVPTGDL ASLTASSYTVNASVSDKARNSASATHNLTVDLAAPVVTINTVAGDDIINATEHGQAQIISGSATGATTGNTVSVT IGTTTYTTVLDANGNWSIGVPASVISALAQGDVTITATVTDSAGNSGTASHTVTVALGAPVLAINTIAVDDIINA AEKGADLAITGTSNQPAGTQITVTLNGQNYTTTADASGNWSVTVPASRVSALGEATYTVTAAATDADGNSGSASH NVQVNTALPGVTINVVATDDIINAAEAGVEQTISGQVTGAAAGDTVTVTLGGATYTATVQANLSWSVDVPASALQ ELGNGELTISASVTNSVGNTGNGTREITIDANLPGLRVDTVAGDDVVNIIEHGQALVITGSSSGLAAGSNVTLTI NGQTYVAAVLADGTWSVGVPAVDVSAWPAGSVTIAASGSTSAGNPVSVTHPVTVDLSAVAVSINAITADDVINAA EKGAALTLSGSTSGVEAGQTVTVTFGGKTYSATVAANGSWSTSVPAADMAALRDGDASAQASVSNVNGNSATTTH AYSVDASAPTVTINTIAGDDILNAAEAGAALTITGSSTAEAGQTVTVTLNGTNYTGTVQTDGSWSVSVPSADLST LTASYTVNAAVSDKAGNPASVNHNLTVDTSVPVVTINTVAGDDVINATEHAQAQIISGSATGAATGSTVTVTIGT NTFTTVLDASGNWSVGVPASVVSALANGTVTINASVTDAGGNSGSATHQVTVNTGLPTITFNAISGDNILNADEK GQPLTISGGSTGLATGAQVTVTLNGHNYSATTDASGNWTLTVPVSDLAALGQANYTVSASATSAAGNTASSQANL LVDSGLPDVTINTVAGDDIINAAEAGADQTISGVVTRAAAGDTVTVTLGGNTYTATVQSNLSWSVSVPTADLQAL GNGDLTITASVTNANGNTGSGTRDITIDANLPGLRVDTVAGDDIVNSIEHGQALVITGGSSGLNAGAVLTVTINS VAYSATVQADGSWSVGIPAANVSAWPAGPLTVEVDGQSSANNPVSVSHPFTVDLTAVAISINTVASDDVINAAEK GTNLTLSGSTSGIESGQTVTVTFGGKTYTASVAANGSWSVNVPAADLATLPEGAANVQASVSSASGNSASATHAY SVDASAPTLTINTIASDDILNAAEAGSPLTISGTSTAETGQTVTVTLNGATYTGTVQADGSWSVSVPTSALGALN ASNYTVSATVNDKAGNPGSASHNLAVDTTAPVLTINTVAGDDIINDAEHAQALVISGTSSGGEGDVVSVVLNGKT YTTTLDASGNWSVGVPAADVTALGSGAQTITASVSDRAGNSDDASRTVTVSLSAPVISINTIAGDDVINATEKGS DLALSGTSDQPAGTAITVTLNGQNYSATTDASGNWSVTVPASAVSALGEATYSVTASVTNAQGNSSTASHNVQVN TALPGITINPVATDDIINASEAGSAQTISGQVTGAAAGSTVTVELGGKTYTATVQADLSWNVSVPAADWQALGNG ELTVNASVTNAVGNTGSGTRDITIDASLPGLRVDTVAGDDVVNIIEHAQAQVITGSSSGFAAGTALTVVINNQTY AATVLANGSWSVGVPATDVSNWPAGTLNITVSGANSAGTQTSITHPLTVDLTAVAISMNSITSDDAINAAEKGAA LTLSGSTSGVEAGQTVTVTFGGKTYTTTVAANGSWSTTVPAADLAALRDGDASAQVRVTNVNGNSATATHEYSVD SAAPTVTINTIASDNIINASEAAAGVTVSGTSTAQTGQTLTVTLNGTNYQTTVQTDGSWSLTLPASDLTALANNG YTLTATVSDLAGNLGSASKGVTVDTTAPVISFNTVAGDDVINNVEHIQAQIISGTATGAVAGDRLVVTIAGQQYV TSTDASGNWSVGVPASVISGLADGTVTISATITDSAGNSSTQTHNVQVNTAAVSLSVSTISGDNLINAAEAGSAL TSGTGTNFATGTVVTVLLNGKGYSATIQSNGSWSVNVAADVAALSDGTSYTVSSAQDSAGNSATSRSVAVDLTAP VISINTVSTDDRNAAEQQQPLTLNGSTSAEVGQTVTVTFGGKTYTATVAANGTWALNVPAVDLAALGQGAQTITA SVNDRAGNPGQATHALTVDTVAPTVTIATVAGDDIINNAEQLAGQTISGTTTAEVGQTVTVTFNGQTWSATVGSG GSWSVFIPAQQFAGLSDGSYTISATVSDQAGNPGSASRGVTLNGDVPTVTINTFAGDDVVNAAEHGSSLVISGTT TAPVGQTLTLTLNGKTYTTTVQTGGSWSYTLGSADVTALADGNAYVINASVSNAIGNTGSSNHTITVDLSAPAMG INIDSLQADTGLSASDFITSVSPVVVNGSLTAALASNETAQISIDGGTTWTTLTVTGTTWRYNDSRTLTDGNYLY QVRVIDAAGNVGATDSQNVVIDTTAPDPAVKTIAISAITTDMGLITNDFVTSDTTLAVSGTLGATLSAGEFAQIS LDGGVTWTTLTVVGTSWSYADGHTLTDGTWNYTVRVVDLAGNVGQTATQNVVVDTTSPEAAKSITITGIDDTGTS SSDFITSDTTLTVRGVLGAALGANEFAQISTDNGATWVNVTVAADSLNWSYVDGRTLTNGTTTWQVRVVDLAGNV GATSSQSALIDTVNPAQVLTIASISTDTGSSATDFITSDTMLTLTGSLGAGLASGEVAQISLDSGATWTTLTTNG TQWTYTDSRTLTDGSYVYQVRVLDLAGNTGPVVSKTVVVDTINPTATPTIVSYTDDVGQRQGTLSSLQATDDTTP LLNGVLSAPLASGEVVYLYRNGLLLGAVTMVGALNWTYSDSGLVSGAYTYSARVVDLAGNITSSSDFVLTVDTSI PTTLAQITSQTTRDTTPIISGVITAALASGQYVEVVINGKTYTSEPGGAVVVDPAHNTWYVQLPDTDALTVSATA YTVTAQVKSSAGNGNNANISNGTVTVNAAIDYTPTWTTASKTTAWGLTYGLDSHGMWTVLANQQVMQSTDPLTWS KTALTLYQSGNNYATSSIADYDRNGTGDLFITRDDYGTGYINGFTNNGDGTFSSAIQVTVGTLTWYGSIVAFDKE GDGYLDFWIGDAGGPDSNTFLWNNAGTLVGNSTTSNSGGSATVGGAVTGYLSLNEGSGVDLNNDGRIDLVQHTYN LNNYYTLSSLINQGNGTFVWGQNTTNTFLSGAGSGAMSSSVSMTWADFDGDGDMDLFLPASQGRANYGSLLFNTN GVLGCPVAVGATATTYASQFSLAVDWNHDGLMDIARIAQTGQSYLYTNVSNASNWTQSALGGSQSGTTSGVAAMD YDWDGAVDVLVSKQSGSVFLSRNTNTVSYGTSLHLRITDPNGINVYYGNTVKLYNSAGVLVATQIINPQSGMGVN DTSALVNFYGLNAGETYNAVLIKSTGTTASNIDQTVNTSWGGLQATDATHAYDLSAEAGTASNNGKFVGTGYNDT FFATAGTDTYDGSGGWVYSSGTGTWLANGGMDVVDFRLSTVGVTANLSSTAAQATGFNTSTFTNIEGISGSNFND ILTGSSGDNQLEGRGGNDTLNIGNGGHDTLLYKLLNASDATGGNGSDVVNGFTVGTWEGTADTDRIDIRELLQGS GYTGNGKASYVNGVATLDAQAGNIGDFVKVTQSGSDTIVQIDRDGTGGTFATTNVVTLTGVHTDLATLLANHQLM VV Escherichia coli O157:H7 NYSGXRC-6056c SGX Pharmaceuticals 2003-01-30 active Selected HI1511 MTISFNTVPSNTLVPLFYAEMNNSAANTAVTSAPALLIGHASNDAAIEVNSLVLMPSADYARQICGAGSQLARMVE VYRQTDPFGELYVIAVPEARGAAATVRVTVAGEAEESGTLSLYVGRSRVQVPVVNGDDATAVATAIKEAVNGVIT LPFTASSDAGVVTLTARHKGLYGNELPVCLNYYGSGGGEILPAGLRVVTEVGAAGSGAPDLTAAVAAMGDEAFDF IGLPFNDAASINMMMTEMNDSSGRWSYARQLYGHVYTAKLGTLSELVGAGDMHNQQHITLAGYEKETQSPVDELV ASRLAREAVFIRNDPARPTQTGELVGMLPAPKGKRFIMTEQQTLLSHGVATAYVEGGTLQIQRSVTTYKKNAYGV ADNSYLDSETLHTSAYVLRKLKSVITSKYGRHKLANDGTRFGPGQAIVTPAVIKGELLATYRQMERAGIVENYDL FKQYLIVERDADNPNRLNTLFPPDYVNQLRVFAVVNQFRLQYSEESA Shigella flexneri NYSGXRC-6056d SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1511 GENBANK NP_274135.1 MPHIDFDTIPGSIRVPGQYIEFNTRNAVQGLPQNPQKVLMVAPMLTAGIQPALEPVQLFSDAEAADLFGQGSLAHL MVRQAFANNPYLDLTVIGIADHSAGVQATATVTLSGTATAPGVVEITIGGKQVSTAVNTGETAATVADRLKTAIT AADVTVTASGSGAAVTLTAKHKGEIGNESGLTVSTGNTGLTYQANAFTGGAKNADIATALSKVAGKHYHIICSPF SDDANAKALSNHITNVSNAIEQRGCIGVLGMSAALSTATTATGEINDGRMTCAWYKGAVEPNGIIAAGYAAVLAF EEDPAKPLNTLEIKGLAVTPDAQWPLFAECNNALYNGLTPLTVVNNRVQIMRAVSTYTKSANNTDDPALLDITTI RTLDYVRRSVKERIALRFPRDKLSDRLLPKVKSEILDVLIKLDQAEIIENAEANKGKLVVARAQNDPNRVNAIIP ADVVNGLHVFAGRIDLIL Neisseria meningitidis NYSGXRC-6057a SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1521 VLAVRCDQLVEVNSKAHTLIKERMPGQATLLLEEWEGFYGLPECGRQIVGKTLVQRQKQVQEKENEVGSNSKRFLE EIATQAGFKVRVVNHYPHHCLRDCTYPLYEQANHWRIFMYTPAVSSIRYATCLDDVVKNLTIFERNKELECLLKR YQYAHLEFVFIYEEETQ Haemophilus influenzae NYSGXRC-6057b SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1521 GENBANK NP_415671.1 MDVTNDDYIRLLSALLPPGPVWSASDPAIAGAAPSLTRVHQRADALMRELDPRTTTELINRWERLCGLPDECIPAG TQTLRQRQQRLDAKVNLAGGINEDFYLAQLAALGRPDATITRYDKSTFTCSSACTDAVNAPEWRYYWQVNMPATT NSTWMTCGDPCDSALRIWGDTVVECVLNKLCPSHTYVIFKYPE Escherichia coli NYSGXRC-6058a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1535 GENBANK NP_439684.1 MALRRVKNPEMWNDDLYNLMFRFTKPNGTFATFTAASAVRKGLESAGFNVTKRKGFGKKRECLSGLKIQSKSTALS TPWYLAQPAKMEKQDVAIIGGGIASLCAAISLIKRGAKVTIYCEDDALALNASGNKQGAFYPQLSDDNALTVDFY LHAFSYGRQLLDWAIEQNIVFEHEFCGVALCAYNEKSAVKLTKISQLGLPNEIFQMLSAEQLSEKVGLPLNCEGG WIEQGAWLAPRQFVQNAFSFLEKQGVVIKTAQKITALSQLEKGWELKNMQGQKYCHEVVILANGHKITDFVQTEK LPLYPIRGQVSQIPTSENLLKLKSVLCYDGYLTPANQLKTSHCIGASMFVIMLIAILANKNNKKINKNSSKISPN LGRKMWIHQIISLV Haemophilus influenzae NYSGXRC-6058b SGX Pharmaceuticals 2004-11-12 active Selected Cloned Expressed Soluble Purified HI1535 ICEDB: T1317 GENBANK AAG57453.1 LRSLTHIAKIELPPVRRVTYVKHYSIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNQLEARFPEHP HPLFVVAESGFGTGLNFLTLWQAFDQFREAHPQAQLQRLHFISFEKFPLTRADLALAHQHWPELAPWAEQLQAQW PMPLPGCHRLLLDEGRVTLDLWFGDINELISQLDDSLNQKVDAWFLDGFAPAKNPDMWTQNLFNAMARLARPGGT LATFTSAGFVRRGLQEAGFTMQKRKGFGRKREMLCGVMEQTLPLPCSTPWFNRTGSSKREVAIIGGGIASALLSL ALLRRGWQVTLYCADEAPALGASGNRQGALYPLLSKHDEALNRFFSNGFTFARRLYDSLPVKFDHDWCGVTQLGW DEKSQHKIAQMLSMDLPEELAVAVEANAVEQITGVTTNCSGITYPQGGWLCPAELTRNVLELAQQQGLQIYYQYQ LQDLSRKDDCWLLTFAGDQQATHSVVVLANGHQISRFSQTSSLPVYSVAGQVSHIPTTPELAKLKQVLCYDGYLT PQNPANQHHCIGASYHRGSEETAYSEDNQQQNRQRLIDCFPHAQWAKTVDVSKKEARCGVRCATRDHLPMVGNVP DYEATLVEYASLAEQKDKAVSAPVFDDLFMFAALGSRGLCSAPLCAEILAAQMSDEPIPMDASTLAALNPNRLWV RKLLKGKAVKAG Escherichia coli O157:H7 NYSGXRC-6058c SGX Pharmaceuticals 2003-01-30 active Selected HI1535 MSDFQHAQLDWDENGQPLSRAFGDVYFSRHSGLNETRHVFLATNRLAERFAALGDGEVLCIGETGFGTGLNFLCAW QLFERVAPAGARLEFVSVEKFPLAAADLRRALALWPELAPWSEALLGQYLAVHPGFQRLAFAGGRVGLTLLLGDA LECLPQLDARVDAWFLDGFAPAKNPDMWSPVLFAELARLSAPQATLGTFTSAGFVRRGLVEAGFAMQRVPGYGQK REMLSGTYQGPPANAGKPWYARPAPHAGRRAALVVGGGLAGCASAASLAARGWQVTLIERHPGLAREASGNPQGV LYLKLSAHGTPLSRLVLSGFGHTRRLLERLRRGHDWDACGVLQLAFDAKEAQRQAQLAAAFPADLLHGLEREQAE RLAGVALPAGGLFYPEAGWVHPPALCQALAATPGITLLSGRAVRLRREGDDWCAYAGDECLARAPLAILATAADI RDFPPAAELPLKRIRGQVTRLPATPQSRALRTVVCAEGYVAPPRGDEHTLGASFDFKSEDLAPTLAEHQGNLELL REISPDLLQRLGADDLPLERLEGRAAFRCTSPDYLPLVGPLAERAAFDEAYAVLARDARQVPERACPWLPGLYLN SGHGSRGLISAPLSGELLAAWICGEPLPLPRAVAEACHPNRFLLRDLVRGQRG Pseudomonas aeruginosa NYSGXRC-6058d SGX Pharmaceuticals 2003-01-30 active Selected HI1535 LRHQAHIVKIAIPPVRRVTYVKQYAIQPATLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNRLAERFPVHS HPLFIVAESGFGTGLNFLTLWQAFDSFRSAHPQATLQRLHFISFEKFPLTRDDLALAHQHWPELAPWAEQLQAQW PLPLPGCHRLLLDRGRVTLDLWFGDINELTDQLDATLNQTVDAWFLDGFAPAKNPDMWTPNLFNAMARLARPGAT LATFTSAGFVRRGLQEAGFTMQKRKGFGRKREMLCGVMEQHLMPTLSAPWFYRSGSEKRETAIIGGGIASALLSL ALLRRGWQVTLYCADDQPAQGASGNRQGALYPLLSKHDAAINRFFPTAFTFARRLYDALPVSFDHDWCGVTQLGW DEKSQQKIAQMLSLALPAGLASALNAEEAEQAVGVTTRCGGITYPAGGWLCPEQLTRAVIALATEQGLQTRFRHT LTSLVAQESRWQLRFTSGETASHETVVLANGHQINRFDQTQPLPVYAVGGQVSHIPTTPALSALRQVLCYDGYLT PQNPHNQQHCIGASYHRGDESTVWREEDQRQNRQRLLDCFPDAKWATEVDVSGNSARCGVRCATRDHLPMVGNVP DYHATLTHYADLADNKTSAAPAPVYPGLFMLGALGSRGLCSAPLCAEILAAQMSNEPIPLDAGTLAALNPNRLWV RKLLKGKAVK Salmonella typhimurium NYSGXRC-6058e SGX Pharmaceuticals 2003-01-30 active Selected HI1535 LFIMSSISHAQLGWNDAGTPVSDQFDDVYFSNVNGLAETRYVFLEQNHLPQRWHNDDQRRFVIAETGFGTGLNFLA VWQAFVAFREANPDAKLKELHFISFEKYPLSKSDLIQAHQAWPELAQFAQKLHKHYPLAIPECQRIVLNDGLVTL DLWFGDIKDCLPKVATQEQGLVDAWFLDGFAPSKNPEMWNQNLFAGMAKLAKHGCTCATFTSAGFVRRGLIDAGF AMKKVKGFGTKREMIAGSLSEKVPYTNIAPEFRFEATHGLQEVAIIGGGIASATLATTLARRGVAVTLYCADEKP AQGASGNRQGAVYPLLSGDHNAVSRVFAPAFLFARQWIEQAAEQINFDHDWCGVTQLMWDEKATDKLKSMLEGNF PTQLVHGLSAEQTNQQVGVPVDKASVHYPLGGWLSPAELTQGLIHLLEQQGKLTAHYQTPIDALTWQPETQLWQL RSGDTLMSHQCVVIASGHQFDSLSQTAELPLGKVKGQVSHIPTTETLSKINSVLCYDGYMTPVSQQNGYHCIGAS YDRQHLDATFDPQAQHENAQKLIHCLPEQTWPLEVDVSGNQSRQGVRCVSRDHLPFVGNVGEFSKITEQYRDLAQ QHQAEPIALYPQLYALVGLGSRGLSSAPLMAELLASQMCGDPMPLGVDLLEQLHPSRMWVRKLRKGKALTQKV Vibrio cholerae NYSGXRC-6058f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1535 MPRGLILATPQLPPDGTPFSARYDDVYHSTEGGLAQAHHVFLGGNGLPGGWQGKRSFTIVETGFGQGLNFLATWAA WRDDPQRCGRLDFVSVEKHPFDRAGLALVHAQEGALASLAEALRQAWPVPVPGVHRLVFDAGRVTLTLMLGDAET LLPQLSCAADAFYLDGFSPAKNPDLWQPGVFKQLARIARGGATLATYTAAGAVRHGLREAGFEVRKAPGFGRKRD MTVAAFPTHWRTRRGPAEAPVWPERHAIVLGAGLAGCSVAERLAARGWRITLIDEHEAPAGGASAHRAAAMHPHV SIDDSVLSRLSRAGNLLARRHWEALDRAGFATGFHPTGVLQLAEHADDAAEQQRIVQALGFPADFIAWLDAARAA DRVGAGVPQGGWWFAQAGWVAPPDICRAALAAAGEAVELRWRTRIESLLRHDAGWRACDAQGNVIAHAPVVVLAN SLDAVRLAPLASAALKPVRGQLTDVPVAALEDGVPWPRAVVCGDGYLLPRERGAPTVRVGSSFQPGETDPDARTA DHAANLRRLAGLQPAHAAALARVDPARLLGYVGVRCVSANRLPLIGAVADEAAIMAPGFRLRGPHAALPRVPGLY AALAYGSRGLTWSVLGAELLAAQIDGGPLPLESELAAALDPGRFLMRALRHGKHAA Ralstonia solanacearum NYSGXRC-6058g SGX Pharmaceuticals 2004-11-10 active Selected Cloned HI1535 GENBANK NP_109739.1 METRDVLIVGGGVIGCATAYELSQYKLKVTLVEKHHYLAQETSHANSGVIHTGIDPNPHKLTAKYNILGKKLLNTY FKRLGFPRQKIRTLIVAFNEMEREQLEVLKQRGIANQINLEDIQMLSKEETLKLEPYVNPEIVAGLKIEGSAIDP VLASKCLALAAQQNKVQICTNTEVTNISKQVDGTYLVTNNETTPSFKVKKIIDAAGHYADYLAHLAKADDFEQTT RRGQYVVVTNQGELHLNSMVFMVPTIHGKGVIVSPMLDGNFLVGPTALDGVDKEATRYITKDAPCMLTKIGKHMV PSLNINNALISFAGSRPIDKATNDFIIRVAHNDPDFVILGGMKSPGLTAAPAIVREAVRLLNWKLTKKPNNGKYN LPWI Mycoplasma pneumoniae NYSGXRC-6059a SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1603 ICEDB: T1324 GENBANK NP_439745.1 MAMNNILGLFAHSPLKPLQKHSEKVTECSDLLIPFFQTTFSKNWEQAEEKRLEISQCEREADSLKREIRLKLPRGL FLPIDRTDLLELVTQQDKLANYAKDIAGRMIGRQFGIPEEMQEEFLHYVKRSLDAIHQAHRVIEEMDKLLETGFK GRELKLVNDMIQELDSIEDDTDQMQIKLRKMLYTIESRYNPIDVMFLYKIIEWVGVLADQAQRVGSRIELMLARS Haemophilus influenzae NYSGXRC-6059b SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1603 ICEDB: T1325 GENBANK NP_253895.1 MPTNPFISLFGRSPIGPMQQHIAKAHECAAGLLPFFRAVIAEDWAQVEQVQQDMVRLEQEADRLKKHVRMHLPKSL FLPVPRSDLLELLSVQDKVANRAKDIAGLMLGRRMRIPLPLQGQMLAYVQRSVDASAQALRVVNELNELLETGFG GRETSLVESMVEELEAIENDTDRIQVEVRRELFRLESELPPVDVMFLYQIIEWIGDVADRAQRVGNRLEQLLAR Pseudomonas aeruginosa NYSGXRC-6059c SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble Purified HI1603 ICEDB: T1328 GENBANK NP_228073.1 MKFIEKMLPEESPIDLLINLSRRGEAAVVLLKDAIEDYFTGKFGEGHLNRVISLERESDEIKSKLKKMYLKMKYTY FEKDDFLYIVHKADEILDVVRDIVIMLDMNRVEDVPENIKELFAELVENVLDTIRETTEAIEQLRTLAESGFSPF EKEKEEREIFDVSMEEREVDTISRNLGKKLYSLKNSMNPVDLIFLNKVARLISKIADQGKDITKRINSILR Thermotoga maritima NYSGXRC-6059d SGX Pharmaceuticals 2004-11-13 active Selected Cloned Expressed Soluble Purified HI1603 ICEDB: T1329 GENBANK NP_232070.1 MTMPVNTIMGLFAKSPIKPLQRHVVCVNECCSHLINFFEVCNKGDWEKAGEIRAQISHLEKEADVLKREIRLKLPR GLFMPVDRSDMLELLTQQDKLANLAKDIAGRVYGRQLVIPEPLQENFIAYVRRCLDAANQAQNVINELDELLETG FKGREVTLVAEMIHQLDVIEDDTDSMQIRLRQQLMAIESKMNPIDVMFLYKILEWVGGIADQAQRVGARLELMLS RS Vibrio cholerae NYSGXRC-6059f SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble Purified HI1603 ICEDB: T1326 GENBANK NP_578750.1 MQVWTKLFAKSPFKPLIKHAEVVVETVETLEKALEAWAKGDYEKMKELAVEVDRLEDVADRIKMELRESITAKLLM PVQRSDVLEYLHMQDKIADAAEDTAKWLLVRDRGNVPEDIKDIILKMGKESIRAAKLVYEAIKQMDMVVESGFSE NEIKKEYDLIRQIEEVENKIDGLDTKLMRLVLNANISWTEGIYLLNIGRTISNISDKAKDAAERIRIMMSK Pyrococcus furiosus NYSGXRC-6059g SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1603 GENBANK NP_142597.1 VIKMQVWKKLFAKSPFKPLIRHAEVVVQTVETLEKALDSWARGDYENMKEYAKKVDDLEDIADKIKSELRDSITSK LLMPVQRTDILEYLHMQDKIADAAEDTAKWLLIKRNLDSIPNDIKDIILKMGKESIKAAKLVYEAIKQLDNVLES GFAEKEIKKEYKIIKQIEEVESKIDGLDSKLMEIVFTSELDWKDGLYILNIARTLSNISDKAKDTAERIRVLMNK Pyrococcus horikoshii NYSGXRC-6060a SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1628 ICEDB: T1331 GENBANK NP_439770.1 MENWTNEIWVAIGIAFIVGLFIGYIIVRLTKGSVKHQAKTEAELKTVKTQLDTQKAQIEKHFAESAELFKTLINDY QKLYRHYATSSNNLLGEKDQKGLFTQQLITATDKSQNEQPRDYSEGASGLFKENKEEN Haemophilus influenzae NYSGXRC-6060b SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1628 GENBANK NP_462257.1 MFMTWEYALIGLVVGIIIGAVAMRFGNRKLRQQQALQYELEKNKAELEEYREELVSHFARSAELLDTMAHDYRQLY QHMAKSSSSLLPEMSAESNPFRNRLAESEASNDQAPVQMPRDYSEGASGLLRSGAKRD Salmonella typhimurium NYSGXRC-6060c SGX Pharmaceuticals 2003-01-30 active Selected HI1628 MPWIYAIAGLLVGIAVGMLIARLTTPQYKTQKNLQKELESAKFTLEQQRQELSDHFAQTAEMLDTLGKDYTKLYQH MAKTATDLIPNLPEQDNPFSKLAQQKEESKQPEELEQPPKDYALGATGLLRGEEKAIIRSADLLNAKAS Vibrio cholerae NYSGXRC-6060d SGX Pharmaceuticals 2003-01-30 active Selected HI1628 MISKDILKNKEYDFIKTNKHLGKNIILLGLSGSYSYGTNNENSDIDVRGVALNRKSDLIGMTSFEQYVDDNTDTCI YAFNKIINLLLNCNPNTIELLGLNKEHYLYLNEIGQELLNNKKIFLSKRAIHSFGGYATAQLRRLQNALARDSYP KEEKEKHIFNSVKNAVHDFSKRYSSFDEGSLKIYLDKSNQPGFDLEIYLDANLKHYPLRDYKNIWAEMSNIVKDY DKIGKRNKKKDDNHLNKHAMHLIRLFMMAIDILEKGEINTYRVHEKELLLNIRNGKFQKEDGNFSDDFYSLLKEY ENRLTYAANNTSLPEEPNMTKVEEFVMSVNERVVKDEI Clostridium acetobutylicum NYSGXRC-6061a SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1654 MTDLTGILYIVATPIGNLQDITQRALETFAQVDLIAAEDTRHSGLLLSHYGIKKPFFALHDHNEQEKAHILVEKLK QGSNIALISDAGTPLISDPGFHLVRQCREAGIRVVPLPGACAAITALCASGIASDRFCFEGFLPAKSKARKDKLE NIAEEDRTLIFYESTHRILDTLEDMQAVLGEERYIVLAREMTKTWETITGNTIKNLREWLLEDPNRTKGEMVLIV EGKPKSDNNDEISPQAVKALELIAEELPLKKAAAIVAELYGYKKNALYQFGLAHLEK Haemophilus influenzae NYSGXRC-6061b SGX Pharmaceuticals 2003-01-30 active Selected HI1654 VSAGTLFVVATPIGNLDDISPRALRVLREVALVAAEDTRHSIRLFQHFGIETPLAACHEHNEREEGGRFISRLQGG EDVALISDAGTPLISDPGFHLVRQAQALGIRVVPVPGSCALIAALSAAGLPSDRFIFEGFLPAKAAGRRSRLQAV QEEPRTLIFYEAPHRLLESLADMRDVFGGERRAVLARELSKTFETIRSLPLAELHDWVASDSNQQRGECVVLVAG WQAPEGEESIGAEALRVLDLLLAELPLKKAAALAAEITGVRKNLLYQQALQRQGKS Pseudomonas aeruginosa NYSGXRC-6061c SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1654 GENBANK NP_345422.1 MQIQKSFKGQSPYGKLYLVATPIGNLDDMTFRAIQTLKEVDWIAAEDTRNTGLLLKHFDISTKQISFHEHNAKEKI PDLIGFLKAGQSIAQVSDAGLPSISDPGHDLVKAAIEEEIAVVTVPGASAGISALIASGLAPQPHIFYGFLPRKS GQQKQFFGLKKDYPETQIFYESPHRVADTLENMLEVYGDRSVVLVRELTKIYEEYQRGTISELLESIAETPLKGE CLLIVEGASQGVEEKDEEDLFVEIQTRIQQGVKKNQAIKEVAKIYQWNKSQLYAAYHDWEEKQ Streptococcus pneumoniae NYSGXRC-6061d SGX Pharmaceuticals 2003-01-30 active Selected HI1654 MAVLYLVGTPIGNLADITYRAVDVLKRVDMIACEDTRVTSKLCNHYDIPTPLKSYHEHNKDKQTAFIIEQLELGLD VALVSDAGLPLISDPGYELVVAAREANIKVETVPGPNAGLTALMASGLPSYVYTFLGFLPRKEKEKSAVLEQRMH ENSTLIIYESPHRVTDTLKTIAKIDATRQVSLGRELTKKFEQIVTDDVTQLQALIQQGDVPLKGEFVILIEGAKA NNEISWFDDLSINEHVDHYIQTSQMKPKQAIKKVAEERQLKTNEVYNIYHQIS Staphylococcus aureus NYSGXRC-6061e SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1654 MQKQKSFDKQTTKGKLYLVPTPIGNLEDMSIRCLNILKEATVIASEDTRNTQKLLNHFEITTPQISLHEHNYKERI PQLITRLLNGETIAQVSDAGMPSISDPGHELVTACLEEELAVIALPGPTAGMTALIASGLLPQPFTFYGFLPRKK KEQKDVLSALKEERPTQIFYESPYRIAKTVATFAEVYGQERPAVICRELTKLHEEYLRGTLGELTEYLAENTLKG ECCLLVSGFTGEKETIAAMPAISLKEHVQVLMEEEGRSSKEAIKEVAKLRNVKKQEVYKEYHSI Enterococcus faecalis NYSGXRC-6061g SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1654 GENBANK NP_215519.1 MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDIRIGGRVVSLFDRVEALRVTALLDAIN NGATVLVVSDAGTPVISDPGYRLVAACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLA ELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGEITVVVAGA APHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSRRETGGPAQP Mycobacterium tuberculosis NYSGXRC-6061h SGX Pharmaceuticals 2004-11-11 active Selected HI1654 LGKLIIVGTPIGNLEDITIRALKTLREVDLILAEDTRRTMVLLNKYRIKKPLLSFNERNSKKRIKEILPLLKEGKK VAIVSDAGMPVISDPGYNLVEECWREGIEVDIVPGPSALTSAVAVSGFPGSKFIFEGFLPRGKNRRRLLKSLKKE NRVIVFFESPERLLSTLRDILEIIGDREVFIAREMTKLHQEFFRGKVSEAISHFEKKKPLGEITVVLSGKE Thermotoga maritima NYSGXRC-6061i SGX Pharmaceuticals 2003-01-30 active Selected HI1654 VLYFLPTPIGNLADITLRALEVLERCEVFLCEDTRVSKRLLHLLAQNPIISHSFPNIATKKREFIAFHSHNDQEFL NQIKPSFFDKEIAVMSDAGMPSLSDPGMSLAAYALKHNIQYDVLPGANALTTAFCASGFLEGRFFYAGFLPHKSK ERRLKIAKILNALAYLEEKTPVVFYESPHRLLETLKDLNDLAKGMHLFAAKELTKLHQQYYLGEVSQIIERLQQS TIQGEWVLVLLNEKKIEPCMGLSALLELDLPPKIKAKIEAVMTQKNAKELYFQRLLEEKNQ Helicobacter pylori NYSGXRC-6061j SGX Pharmaceuticals 2004-11-13 active Selected Cloned Expressed Soluble Purified HI1654 ICEDB: T1347 GENBANK NP_230233.1 MTDNKTVPNGAPILYIVPTPIGNLGDITQRALDVLASVDMIAVEDTRHTGKLLAHFNISTKTFALHDHNEQQKAQV LVDKLLSGLSIALVSDAGTPLISDPGYHLVTQCRQAGVKVVPLPGPCAVITALSASGLPSDSFSFEGFLPAKSKA RKDKLLEIAKVSRTCIFYESPHRICESLQDMLDVLGGEREVVLARELTKTFETIQGMPLAELITWIAEDDNRKKG EMVLLVHGYRDAGEQQLPDEALRTLTILTKELPLKKAAALVAEIHQLKKNALYKWGLENLGE Vibrio cholerae NYSGXRC-6061k SGX Pharmaceuticals 2003-01-30 active Selected HI1654 MKQNESADNSQGQLFIVPTPIGNLADITQRALEVLQAVDLIAAEDTRHTGLLLQHFGINARLFALHDHNEQQKAET LVAKLKEGQNIALVSDAGTPLINDPGYHLVRTCREAGIRVVPLPGPCAAITALSAAGLPSDRFCYEGFLPAKSKG RRDALKAIEAEPRTLIFYESTHRLLDSLEDMVAVWGESRYVVLARELTKTWETIHGAPVGELLAWVKEDENRRKG EMVLIVEGHKAQEDDLPADALRTLALLQAELPLKKAAALAAEIHGVKKNALYKYALAQQEE Salmonella typhi NYSGXRC-6061l SGX Pharmaceuticals 2003-01-30 active Selected HI1654 MQTDPKPGTLYIVGTPIGNLEDITFRAVRILQNVDLIAAEDTRHTGKLLQHLQVKTPQVSYHEHNRTSRIPELLKH LHSGKAIALVSDAGMPGISDPGYELVKACVEVAIPVVPIPGASAAITALSAAGLPTDKFVFEGFLPAKGQQRREH LEALQTESRTLIFYESPHRLRETLQDLAEVWGSDRQIVLARELTKLYEEFWRGSIGEAIAHYQQKEPQGEYTLLV AGNPPSETLLTEEQLKAELQQLMMQGISRSQASRQLTKYTSLNRRQVYQIALSIVINPE Nostoc sp. NYSGXRC-6061m SGX Pharmaceuticals 2004-12-04 active Selected Cloned Expressed Soluble Purified HI1654 ICEDB: T1334 GENBANK NP_240915.1 MKTQQSYQQRDDKGTLYLVATPIGNLEDVTFRAIRTLKEADQIAAEDTRQTKKLLNHFDIATKLVSYHEHNKETMG KRLIDDLIEGRTIALVSDAGMPAISDPGYELVVSAIKEGIAVIPIPGANAAVTALIASGLPTESFQFIGFLPRQK KQRRQALEETKPTKATLIFYESPHRLKDTLDDMLLILGNRHVSICRELTKTYEEFLRGTLEEAVHWAREATIKGE FCLIVEGNGEKVEPEEVWWESLSPVQHVEHYIALGFRSKEAIKQVATDRGVPKRDIYNIYHQE Bacillus halodurans NYSGXRC-6061n SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1654 MSTPGTLHIVATPIGNLGDLSPRAQHILRTVTMICAEDTRHTRQLLAHFGIERPLLALHAHNEDTLAERIITRLIS GASLALVSDAGTPLISDPGFLLVRAARAAGIRVTPVPGPSALIAALSVSGLPSNRFTFEGFLPAKPTARRDRLTH LAHEPRTLIFYEASHRIAECLTDLATIFGSMRAAVVARELTKIFETVLDGTLATLQTQVANDDNQRKGEFVIIVQ GAADQDAAKITEGRRVYALLKEHLPPSSAAKLAAEITGAPRKALYGG Xylella fastidiosa NYSGXRC-6061o SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble Purified HI1654 ICEDB: T1344 GENBANK NP_721992.1 MQVQKSFKEQTAYGKLYLVPTPIGNLQDMTFRSIAILKKVDYIAAEDTRNTGLLLKHFDISTRQLSFHEHNAFEKI PDLLKLLKSGNSLAQVSDAGLPSISDPGYDLVRAAIQEDIAVIALPGASAGITALIASGLAPQPHIFYGFLPRKS GQQKSFFEEKKYYPETQIFYESPYRVQETLENILSVYGDRQIVLTRELTKLYEEYQRGNISEILTYIAENPLKGE CLLLVSGYDHQEKEQQVSEVELKHLVEALVKEGMKPNQAIKKVAKENDFNRQELYQLYHELQ Streptococcus mutans NYSGXRC-6062b SGX Pharmaceuticals 2003-01-30 active Selected HI1695 MMKFSVIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNLKVSQLETNSGGPGKPR NVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIKMKGVNGRGVPQSMFKETAPEVTLLNSRIIYT LSPTKIYRTALLKDNDIYFPEELKSAEDQLFTMKAYLNANRISVLSDKAYYYATKREGEHMSSAYVSPEDFYEVM RLIAVEILNADLEEAHKDQILAEFLNRHFSFSRTNGFSLKVKLEEQPQWINALGDFIQAVPERVDALVMSKLRPL LHYARAKDIDNYRTVEESYRQGQYYRFDIVDGKLNIQFNEGEPYFEGIDIAKPKVKMTAFKFDNHKIVTELTLNE FMIGEGHYDVRLKLHSRNKKHTMYVPLSVNANKQYRFNIMLEDIKAYLPKEKIWDVFLEVQIGTEVFEVRVGNQR NKYAYTAETSALIHLNNDFYRLTPYFTKDFNNISLYFTAITLTDSISMKLKGKNKIILTGLDRGYVFEEGMASVV LKDDMIMGMLSQTSENEVEILLSKDIKKRDFKNIVKLNTAHMTYSLK Staphylococcus aureus NYSGXRC-6062c SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed Soluble Purified HI1695 ICEDB: T1351 GENBANK NP_348793.1 LISVIMPVYNCEKYLEESIESILKQTYRDFEFIIVNDGSNDKSIDIINKYANDDNRIVVVSRDNNMGMVYSLNEGI DRAKGSYVARMDADDIALPERFERQIEYLNKNKDVDILACKVEAFGDVSREQKLEREHWYNVDLNNSESIESLFL ENCYIAHPSVMMKMSVLKALGGYNLNYKRTEDYNLWLRAIAKGYKIAMLEEKLMKIRLHNDSKIHRDAEGFSSIR DIIQSRLEYVKEKLKLKDFSYVIWGASNGGKIAYEKIKEVFPNAKLNGYIDKFKTGKFEGVDIFYPEDLSKMKVD YVFIATLPGCKEAKGILTKNNFVPIKDFLVLC Clostridium acetobutylicum NYSGXRC-6062f SGX Pharmaceuticals 2003-01-30 active Selected HI1695 MKITVIVPTYRRTKDLTRCLESLEKQSRPADEVLVVVRDTDVETWQFLETIAPHSLPLHTTTVRVPGVVAAMNAGL DIAQGDIIAFTDDDAAPHSNWLAQIETHFLAHEQIAGVGGRDWVYHGDRLEDGTCPVVGQVHWFGRVIGNHHIGI GKPREVDVLKGVNMSFRRSAVHGLRFDQRMLGTGAQVHFEVAFCLALKRAGWKLIYDPQIGVNHYPAQRFDEDQR QSFNHLAVTNAVHNETLALLEHLSPTQQLTFLLWATLVGTRDSMGLIQFLRFLPSDRALAGQKLLAAWYGRWRGW RTWQSSIRFAQIKN Nostoc sp. NYSGXRC-6062g SGX Pharmaceuticals 2004-11-17 active Selected Cloned Expressed Soluble HI1695 GENBANK NP_577787.1 MKVSVIIPTYNERENLEELFSRIDNALQGLNYEIVVVDDDSPDRTWEKAQELSSKYPVKVIRRTKEKGLSSAVIRG FKEASGDVFVVMDADLQHPPEVIPKLIEAIKNGSDIAIGSRYVKGGKVENWPFYRKLISKGAIMVGRIALPKIRD IKDPVSGFFALRKEVVEGVELNPIGFKILMEILIKGKYSKVVEVPFTFGIRARGESKLKGKTIFEYLRHIYRLMK WEGEIDRIVKFSIVGLSGILVNEGFLWLFVNLGIPKEIAVIPAVELSILNNFFWNDIWTFKDIRRGSIFSRLLKF HIAALSGAVVNFIVYWILLFLGIHYLIANLVGIVLSFGVRYVINRHVTWAT Pyrococcus furiosus NYSGXRC-6064a SGX Pharmaceuticals 2004-11-13 active Selected Cloned Expressed Soluble Purified HI1698 ICEDB: T1356 GENBANK NP_439840.1 MKKIGFFIMNIGSAGGTERVSINVANALAKQGYDVSFISIGGNKPFFQVDEKINIYAMNKLPYSLKKDYFSITKKL RELVKELQLDTLIVVDGAIMLFSALALVNLNIKHILWEHYSFNFTGNRLVRTLGKYLAVTTCDKIVTLTEAEKTL WQEKFKTNNIISIANPNTLLPKNKLAKLENKTILSVGHLFSYKGFDYLLKVWQVLAKKYPDWNLKIVGSGEEEEN LKNLAKALDIEDSVNFIPRTNDVSFYYESSSIYCLPSQTEGLPLVVIEAMAFGLPIVAFNCSPGVKQLVEHKENG FLCEQNNIEEMVKGLDLLINNPELYLQMSDKSRLMSEDYGIEKIIEEWKGIL Haemophilus influenzae NYSGXRC-6064b SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1698 MNFLKKEPFKIFSMIYLLLDTITNRAGTERAVINLANNLHANGHRVSLVSVCTKEGEPSFQVEKGIEVHHLGIRLY GNALARKTVYFKAYRRIKALYKKREPVLLIGTNIFINTILSQISNRGRIFTIGCEHISYDIARPITKRIRGFLYS GLDAVVALTKRDQQSFEAILRGRSKAYVIPNQVSFTTVQRDATTHKQMLAIGRLTYQKGFEFMIEDASRVLRERP DWKLIIVGDGENESMLRKEIASRNMESQIEIHPSTPEIRKYYESSAIYLMTSRFEGLPMVLLEAEAYALPIISYD CPTGPRELIENGRNGFLVPMEAHEDFADKLRLLMDDETLRKKMGQESELMVKSYSPANIYECWKKLFVEIGYMN Porphyromonas gingivalis NYSGXRC-6064c SGX Pharmaceuticals 2004-11-11 active Selected HI1698 LEELKSKGFDTSKAVVIENPVSEEFFNVEKREEPVILYPATLIPRKNQLGFLRAASTIKEELRDYKIIFTASGDKS YEMELRKLAEKSNLNVEFTGKVSYEKMLELYSKASIVALTSFEETFGMVIAEAMATGTPVIASRVGGIPYMIEDG ETGFLVDPNNPKDIAEKLVTLLSDKHLRSKMGREGKKVAEERWKDEVIARKLLEMYFSAIEQDKNTKR Pyrococcus furiosus NYSGXRC-6064d SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1698 VKLVIDLLGAQTRSHLRGIGRYTRELTKALLRQAGEAHAIHLVLHAPLEQASDALIAEFGALLPRARIHLLRLPRH TSEHLTGNTWRHHAASRLSRYGLTCLDADVVWHSSVFEGYDEDGVLPDAPLFHTNRVATLYDLIPLHDPEVFLPG SLPKAWYERRSAFLSSCDLLFCLSEWTAQEAVQRLHLDPERLVVIGGGVDSNFRPLVFDAQQRGNLLARFSITRP YVLYNGGLDQRKNVPALLRAFALLPMAIRQRHQLVVLGDDREVHRPMMALCRQLGLDQQEVVFTGRVNDSDLVAL YGLCALFVFPSRLEGFGLPVLEAMACGAPTLCSDAASLPEVAGRQDILFPPEDHVALSARMSQVLDDPQWLQSLR DYGLRRATAFTWDRVAQRALDALTRLQVRSSEMKSQRVSEVSPATHTETAAPEMLPITEIQLVTDLAALPGDASR DDLAQAAFSICSMRVAPQAPQWLVDVSQIAKTDIGTGTSRVTRSILREWLSTPPPGVCIVPVYLREGQYHYARSF TAQVLGLVSETPQEGIVMVYPGDVFVGLDWAPEAINAARARLQDWRRVGVATCFVVHDLLPMTLPDCFHPYSRNL FEQWLRTVAHLADAIACISATTAEVLSRWLQDTTVDYQFGIPPQVKHFPLGVSFPEVSTAQEAIREELRTALVMR PTLLIVGTLEPRKGHVHALRICEQLWEQGEDVNLVVVGQRGWSEQALVMRLTRHPEVGRRLFWLSDAADAELSAL YVHATALLALSEGEGYGLPLLEAAHFRLPILARPLPVFLEIMADYPHYLDGTAPDTWSATVAQWLHASDRPISRP VPIASWKESAQQLADIVNDCRFLLDSKKLSAPLK Xylella fastidiosa NYSGXRC-6064e SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1698 GENBANK NP_273887.1 MARHVFLPPLSVHRHRPHPLGVCGFESFQTLHPRKRAARPDSRPLYELCRHTCLQDFPKIRHPLCRHGTQQHHYAR FGAPAPMAAYEKCGGTRRRTSRRQPPFRTRPATQIRLRMAVPPPTYWAEYSTDRLNKEKKNNKPHFVFCTVSHLR RLKGHDVLLTAFARALAQCPQLRLNIGGSGQEEQRLKQQAADLGITHAVTFLGALQPEAVLDLMRNSDAFVLASR TETFGVVYIEALSQGLPVIATRCGGAESIVSDGNGYLVPVDDDDALADALIKMCEHHSDFEPARLRENCLNEFGE NAVIGRLIGIFRQAIAEYGKKIPVKYSGLTKIRTRRRSRRQYK Neisseria meningitidis NYSGXRC-6065a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1701 GENBANK YP_249417.1 MLELGKLLTALIAPPLNTFVLLIIAAIIYCVHFKKLAKFIAIISFTWLYIMSAPFTGLLLTNNDDSPALTLDEYKQ AQAIVILGGGSYQTKELYAETASGAPQLERLRYAAFLQKETGLPILTTGYSLIGISEGDLMAKELNQFFNVPTQW IENKARNTEENASFTKNILIKDHIQKIILVTNQWHMKRAKYLFEKQGFDVLPAAAASYGSKGNLSAKSFIPDLGA LNSNMVLLKEWIGYWKAHYVE Haemophilus influenzae NYSGXRC-6065b SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1701 GENBANK NP_252674.1 MPIRYFFKQLLLPPGGLLLLLFFAFWWRTSRPRLARLCGVCGFFGLWLMSMPLSVEWMARWLESEPALLAEDLPGL AQRADAIVILGAGRQTNDPAWGDDAPSLLAAERLRYAARLAKTSALPVLISGGLHYGRPPSEAALMANALLQDFG VPTRWQEGLSRTTWENATLSAPQLREAGVRRVVLVTQAWHMQRARWSFERQGFEVIPAPVGFLGGANLRPFGGWL PEAQAFWQSGMLLNEAIGLVGYRLFYR Pseudomonas aeruginosa NYSGXRC-6065c SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble HI1701 GENBANK NP_229474.1 MFLQKILGAFLVTPGLFILLLIVGSFFFKKARWFLLALAAIVYLFSSYVGEFLFLWPLEKNLDVPATLPNDAVIVV LGGGVERNTKAGDNLSDATLRRLLTGVQIYQKTKMPILVTGGSLTGLRSEAMIMKDYLVSLGVPEEKITVEDRSR NTYENALFTREKIGDVPIILVTDSIHMRRAVFTFKRFFQSVTPYPAGFYFGDPEFVDFLPNATSFYLNSRAIYEW IGLVWYNFRWR Thermotoga maritima NYSGXRC-6065d SGX Pharmaceuticals 2004-11-11 active Selected HI1701 MFLYLSKLLPLFFYPLGLASVGLVVALVTLRKRPRIATTAIALSLTLLLLCSNAWVAKYLVRSLEWQNLPMAQLPN AEAIIVLGGATKSVFPPRITPDLSEQGDRVIYAAQLYRQNKAPLIILSGGRIDWRGSGSSESTDMANILTSLGIP ASVLIEEPDSLNTYQNAVNVKKILVSRGIDQVLLVTSALHMPRSLKIFQRQGMNVIPAPTDFLVSEGELQELGNT PKAAILNLLPDTYNLHLFTNALKEYVGSFVYWLRGWV Nostoc sp. NYSGXRC-6065e SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1701 MHPHWLLSTLVVTLLLPPGGPLVLALLAGTVAWRVPRWRCPACRGLGIALIAAWVAATPWCGRLLASWTHPAPPLR LDALQPQGEGAVVLLGGSRKLAAREYAGQGATALSGPSLERTVYAARLARAAHLPVLATGGAPEGNGVPEAELMR RLVADMGQDARWIETRSATTEENAAFSAPMLRAAGIRRIYLVTHYWHMARARRYFEGQGFTVTPAPCGWGGEVEE SPAGGILSLLPRTDGLMLTRFALREALGQLWLSIRQGIR Ralstonia solanacearum NYSGXRC-6065f SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1701 MLILSKLLPLLVLPPGICLLLAIAGLLFKRRSLVWISLALLWALSLPVVGQALMHRTEEPWHRVPVEQVRKADAIV VLSGMLQQIHGAPLGEFGEAADRFESGIDLFKAGKAPVLVFTGGQMPWDPDCVPEGELLAARARLRGVPAGSIRL TSTVANTAGEALATALLLGVSPGKPKRIILVTSAFHMQRALMLFMAAGFEVEPCPVDFWATDLKSRTTLLDFIPS ANAMNDSATALREMIGQIVYSSGMRFMTLAR Chlorobium tepidum NYSGXRC-6065g SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1701 GENBANK NP_347081.1 MKRLKQKTVGNVYIILGALGILYFIACRLTFAMYVNFMAFFMILGILCILFGIFYKKHEIKAGSRLSKIDKCIKGI VCAICVVFIFTEAVLVYNGQSEYKGKLDYIIVLGAGLRGKHMLGTQYERVKKAAEYVKENPDVKIVVSGGKGNGE DISEAEAMKQYFLNKGFKNDSIIMEDKSKNTFENLRNSKKILEKISNKKEIRVGVVTSSYHITRAKLLGKRVGLK LYAIPAPINKLLLLQSYTREFFAFYKSIIFDRG Clostridium acetobutylicum NYSGXRC-6066a SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1721 GENBANK O05086.1 VTFKLRETIKINHKKVQRIMQWLGLKGKCKTQKYRSYQGEVGHIADNLLQRDFTATQPNEKWTTDITEFKCAEGKL YLSPIKDLFNNEIIAYDLARSPNFEQITRMMKQAVARLEGAKPILHSDQGWQYQMIGYQNILRENGIQQSMSRKG NCLYNSAMESFFGRLKTECYYGKRFETFEQLEKTIHEYIHYYNHERIQGKLKGLSPVNYRTQSLN Haemophilus influenzae NYSGXRC-6066b SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1721 VKVLNELRQFYPLDELLRAAEIPRSTFYYHLKALSKPDKYADVKKRISEIYHENRGRYGYRRVTLSLHREGKQINH KAVQRLMGTLSLKAAIKVKRYRSYRGEVGQTAPNVLQRDFKATRPNEKWVTDVTEFAVNGRKLYLSPVIDLFNNE VISYSLSERPVMNMVENMLDQAFKKLNPHEHPVLHSDQGWQYRMRRYQNILKEHGIKQSMSRKGNCLDNAVVECF FGTLKSECFYLDEFSNISELKDAVTEYIEYYNSRRISLKLKGLTPIEYRNQTYMPRV Escherichia coli NYSGXRC-6066c SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1721 GENBANK NP_288634.1 MMPLLDKLREQYGVGPVCSELHIAPSTYYHCQQQRHHPDKRSARAQHDDWLKREIQRVYDENHQVYGVRKVWRQLL REGIRVARCTVARLMAVMGLAGVLRGKKVRTTISRKAVAAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAF IIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTIHHSDKGSQYVSLAYTERLKEAGLLASTGSTGDSYD NAMAESINGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLGRLGHAPPAEAEKAYYASIGNDDLAA Escherichia coli O157:H7 NYSGXRC-6066d SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1721 GENBANK NP_215311.1 LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYG ARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVS TWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLA EAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAA YYAQRQRPAAG Mycobacterium tuberculosis NYSGXRC-6066e SGX Pharmaceuticals 2003-01-30 active Selected HI1721 VEVVCSAFDVARSCYYVHRLRRRRVDARRIVLRSQVNQLFSQSRGSAGSRSILGMLREEGVTIGRFRVRRLMRELG LVSKQPGSHAYKQATVERPDIPNRLNREFATEHPNQVWCGDITYVWAQGRWHYLAAVLDLHTRRVIGWAFSAKPD AELVIKALDMAYEQRGKPQQVLFHSDQGSQYASRLFRQRLWRYRMQQSMSRRGNCWDNSPMERLFRSLKSEWVPS TGYLTAQEAQRDISHYLMHRYNWIRPHQFNDGLPPAVAEEKLNPLSGMG Pseudomonas aeruginosa NYSGXRC-6066f SGX Pharmaceuticals 2003-01-30 active Selected HI1721 MKAKYKNHQIETNEKRIKNHLNRAFNREQPMETLVSDLTYVKVGGTWHYICLFIDLFNREIVGYSAGKNKDANLVS KAISRINHNLEQIKLFHTDRDKEFDNHLIDEVLETFKIKRSLSTKGCPYDNAVAEATMKAMKTEFVKQMQFENLE QLETELFDYVNWYNNFRPHSSLQYLTPVAFKNIHMKTV Staphylococcus aureus NYSGXRC-6066g SGX Pharmaceuticals 2004-11-18 active Selected Cloned Expressed Soluble HI1721 GENBANK NP_359039.1 MEQCYTDVTEFAIPASTQKLYLSPVLDGFNSEIIAYNLSTSPNLEQVQTMLEQAFTEKHYENTILHSDQGWQYQHD SYHQFLEGKGIQASMSRKGNSQDNGMMESFFGILKSEMFYGYEKTFKSLNQLEQAIVDYIDYYNNKRIKVKLKGL SPVQYRTKSFG Streptococcus pneumoniae NYSGXRC-6066h SGX Pharmaceuticals 2003-01-30 active Selected HI1721 LETLRFPKSTYMYWQKRLDRTASTQIIEEEIQAIRKKHQHYGYRRITQELKRRGFQVNKKKVQRLIQKLKLQVKAF TKKSRKYNSYKGIVGKIAKNLIRRRFKTSVPHQKITTDTTEFKYFEADNAGIFRQKKLYLDPFMDMYNSEILSYS LSTQPNGKTVMEGLKEAISQTNDCPYRRTFHSDQGWAYQMNVYIQTLKDNNIFQSMSRKGTCLDNSPMENFFSIL KQEVYYGKIYQSQMN Enterococcus faecalis NYSGXRC-6066i SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1721 LSSLLKAANLARSTYYYQMATGQAEDRHGALKERIQHIYAQHKGRYGYRRITATLRRAGTLVNHKTVQRLMSALQL KSLVRPKKYRSYLGQVGRVAPNLLQREFEASKPNEKWVTDVTEFNVGGKKLYLSPVLDLYNGEIVAWQTSERPDY TLIREMLDKALRKLRPCETPMLHSDQGWPYQMAAYRRKLAARGLRQSMSRKGNCLDNAAMESFFGTLKSECFRLE RFADIDQLRRAIAEYIRYYNHERIKIKLKGLSPVQYRTQPLAA Ralstonia solanacearum NYSGXRC-6066j SGX Pharmaceuticals 2003-01-30 active Selected HI1721 LVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRL MKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIA YNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGIL KSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT Streptococcus mutans NYSGXRC-6066l SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1721 GENBANK NP_269449.1 MLLEILDLSRSTYYYQVKRLAQGDKDIELKHVIREIYDEHKGNYGYRRIHMELRNRGFVVNHKKVQRLMKVMGLAA RIRRKRKYSSYKGEVGKKADNLIKRHFEGSKPYEKCYTDVTEFALPEGKLYLSPVFDSYNCEIIDFTLSRSPNLK QAQTMLEKTFPADSYSGTILHSDQGWQYQHQSYHDFLESKGILPSMSRKGNSPDNGMMDSFFGILKSEMFYGLET TYQSLDKLEEAITDYIFYYNNKRIKAKLKGLSPVQYRTKSFQ Streptococcus pyogenes NYSGXRC-6066m SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1721 GENBANK NP_461696.1 MKYVFIEKHQAEFNIKAMCRVFQVARSGWYVWHQRRHQINRRQRFRLVCDNVVREAFSDAKQRYGAPRLTDELRAQ GYQFNVKTVAASLRRQGLRAKASRRFRPVSYRKHGLPVSENLLKQDFYASGPNQKWVGDITYLRTGEGWLYLAVV IDLWPRSVIGWSMSSRMTAQLACNALQMALWQRKCPENVIVHTDRGGQYCSTDYQSLLKRHNLRGSMSARGCCYD NACAESFFHTLRVECIHGEDFVSREIMRTAVFNYSECDYNRWRRHSACGGLSPEQFENQNLA Salmonella typhimurium NYSGXRC-6066n SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1721 GENBANK NP_232766.1 LIIKKLKQSHSVKILCEVFNVHRSSYHYWLKRPALINAETIKLRSLISEAHAASNGSAGARTIADIVTNQGVKLSR YRATKLMRTLGLVSCQEPKHRYRKASQEHIDVPNHLSRQFAVTAPNEVWAGDVTYIWTGNRWMYLAVVIDLFARK VIGWSMSLSPDSRLTGKALSMAYESRGKPKGVMFHSDQGSHYTSRKYRQLLWRFQIKQSLSRRGNCWDNAPIERF FRSLKTEWVPTVGYRSFAEAQQEITRYIIGYYCQLRPHQYNGGLTPNESERLYWENSKTVANFS Vibrio cholerae NYSGXRC-6066o SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1721 GENBANK NP_241201.1 MCDVLQMARSTYYYEAKIRDDQDEELSELIVDIFKNSRDNYGQRKIKIELRKKGWTVSRRRIGRIMKEQGLVSKYT VAQFKPAKTSCNESEIGNTLNREFNQEQELKVVVSDLTYVRVQQKWHYICVLVDLYNREIIGYSAGPHKSAELVQ RAFASVKYNLQRLELFHTDRGSEFKNKLIDQALETFGIERSLSEKGTPYDNAVAEATFKTIKTEFVRGAVFSSQQ ELDLELFDYVHWFNTIRIHGSLDYLTPTEYKLMNL Bacillus halodurans NYSGXRC-6067b SGX Pharmaceuticals 2004-11-05 active Selected Cloned Expressed HI1731 GENBANK NP_286426.1 VQRARCYLIGETAVVLELEPPVTLASQKRIWRLAQRLVDMPNVVEAIPGMNNITVILRNPESLALDAIERLQRWWE ESEALEPESRFIEIPVVYGGAGGPDLAVVAAHCGLSEKQVVELHSSVEYVVWFLGFQPGFPYLGSLPEQLHTPRR AEPRLLVPAGSVGIGGPQTGVYPLATPGGWQLIGHTSLSLFDPARDEPILLRPGDSVRFVPQKEGVC Escherichia coli NYSGXRC-6067c SGX Pharmaceuticals 2003-01-30 active Selected HI1731 MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFPGFIECIPAFTSLTVFYDMYEVYKHLPQGISSP FESVKRDVEERLAEIAEDYEVNRRIVEIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFP FLGGMSKRIAAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRAGDIVKFVR ISEKTITPIRRSPIEHESIKARTAHNGSGYRQNGLPKIRRSGQRRYGHGFTAHCQSVDRKRRNEAGLEITMMGPG PSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVSFGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRG SIGGLHGRALQKEDELNIGEMSALSQTILSRLSSQLAHTVIGSTDVVSQPWEISVIEDESRHSSAGGISICLLHS RIKNAFSEEAFRVTPQSDRMGYRLKGEPLDLTAPLEMVSAAVSFGAAQMPPAGKPYYPCLQDRQDDWPAIRGIAH IISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWLT Bacillus subtilis NYSGXRC-6067d SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1731 GENBANK NP_372133.1 VDVRFINEQTIMIYFENKISEETYRNVTAMVRWIREKEILEIQDIVPSYRAVLIYFDEQAITSSKLIENLELNKFN EKNVHAVNQTNRIIKIPVQYGGTYGPDIEEVAKHNRITVEQVIEKHTSKPYLIYMLGFMPGFPYLGGLDEQLHTP RRNQPRLKIHAGSVGIANNQTGLYPSDSPGGWQIIGRTPLKVFSSEREPMSMYEAGEWIQFYAIDEQKFIQIERD ISDGNFNVDDWVVIENVN Staphylococcus aureus NYSGXRC-6067e SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1731 GENBANK NP_253200.1 VIRIEPAGAEALLLTLAEEPEVDLSVRLAELARRLREGLGEGVRDLVPGWTTLMLHYDPYRIASQILEERLGPLLA EWHAWRPAEDAGRLHEIPVWYAGEDLATVAVACGLTGEGVIELHSAAEYRVGAIGFAPGFAYLGGLDPRLVLPRR ATPRARVPAGSLAIAEAQTAIYPQASPGGWHLLGRSPWRPFDPAATPPCPLALGDRVRFVAIGREAFLDLGGRE Pseudomonas aeruginosa NYSGXRC-6067f SGX Pharmaceuticals 2004-11-11 active Selected HI1731 MDAALACTVLDYGDHALMLQCDSTADAMAWTDALRAAALPGVVDIVAASRTVLVKLDAPRYQGVTRQRLRRLRVTP EAVAAADHRCDLVIDVVYDGPDLAEVARCTGLTTAAVINAHTATGWRAGFSGSAPGFAYLIDGDPSLRVPRRPER RTSMPPGSVALADGFSAIYPSQAPSDWQIIGHTDAVLWDVDRPQPALLTPGMWVQFRAA Mycobacterium tuberculosis NYSGXRC-6067g SGX Pharmaceuticals 2003-01-30 active Selected Cloned Expressed Soluble HI1731 LQCTIHRLGELALLCEVPPPATLTCQQRIWAMASRASEWAGVIDVVPGMNNLTLVFGPQADAQALTALLREAWQES GALIADGKRIDIEVAYGGDDGPDLRDVAAHTGLSPAEVVRRHTAPEYIVYFLGFLPGFAYMGGLDKSLATPRRAE PRMAVPAGSVGIGGEQTGIYPAASPGGWQLLGRTDAALFLPQRDPPALLAPGDRIRFVASKVHA Ralstonia solanacearum NYSGXRC-6067h SGX Pharmaceuticals 2003-01-30 active Selected HI1731 MRIEITPISESALVYRLNAPSELGKQQKLWAFAAALGQHDRIEEVVVGMNNLTVFTRFDTDLATLADELQYVWEHT AVTDHQGKLVEIPVCYGGEYGPDLAEVAAFHQTVISEIVRRHTAQTYTVFMMGFQPGFPYLGGLPEALHTPRRAV PRTSVPAGSVGIGGSQTGVYPFASPGGWQIIGRTELPLFRADLNPPTLLAAGDQVRFVAERIEP Neisseria meningitidis NYSGXRC-6067i SGX Pharmaceuticals 2004-11-11 active Selected Cloned Expressed HI1731 GENBANK NP_459697.1 VQRARCYLLGETAVVLELEPPITLASQKRIWRLTQRLVDMPNVVEAIPGMNNITVILREPQTLALDAIERLQRWWE ESEALEPDSRSVEIPVIYGGAGGPDLAAVARHSGLSEKQVVELHASVEYVVWFLGFQPGFPYLGNLPEPLHMPRR AEPRLQVPAGSVGIGGAQTGIYPLSTPGGWQLIGLTPLKLFDPMRETPVLLRPGDSVRFVPQKEGIC Salmonella typhimurium NYSGXRC-6067j SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1731 GENBANK NP_142904.1 MIIKPAGDSAFLISFGDEISEEINDRVHSLAKAIEKESPEWLVELVPAYSSLLVIYDPLKASYEEVESYLKRISAR EVERIKGKTIEIPVAYGGEFGPDIEFVAQYNGLSVDDVIEIHSKPLYRVYFLGFLPGFAYLGGMDERIATPRLEK PRLKVPAGSVGIAGKQTGWYAIESPGGWRIIGRIPLRTFNPGKVPPSIVLPGDYVKFVPIDEKEFWEIYGREWE Pyrococcus horikoshii NYSGXRC-6067k SGX Pharmaceuticals 2003-01-30 active Selected HI1731 MIATPNILAPLHDILPLTKGEARISFIGSRSFLLEAPGEFDLPAQRWIWALSQSVSNWPDVAEIIPGMTNLLTIFK ETPDDPDSVVGRLRDAWNSAQSLDLTGKTIEIPVHYGGEYATDLAAICDFSGLSDREVVRLHHEATYRVFALGSA PGFGYLHGLDPRIYMPRKTVPSIRMEKGCVTIGGMQTGVAMLTGPNGWNSIGYADLQMFDPESSVPALMAPGDIV RFVPARIEL Agrobacterium tumefaciens NYSGXRC-6067l SGX Pharmaceuticals 2004-11-11 active Selected Cloned HI1731 GENBANK NP_579002.1 MKVRVVGDSCIAIIFGEDISEETNRKVHALADYLLNYNPEWLLDVVPSYSALYVYFDPLMIDYREVIDIIGKIKIN EVERKEKRIIKIPIAYGGEFGPDIEFVAKYNGLSVDDVIEIHSKPLYRVYFLGFLPGFAYLGGMDERIATPRLEK PRLKVPAGSVGIAGKQTGWYAIESPGGWRIIGRTPLRTFNPEKIPPSIVSPGDYVKFVPIDENEFWEIYREEWGN D Pyrococcus furiosus NYSGXRC-6067m SGX Pharmaceuticals 2004-10-16 active Selected Cloned HI1731 LLVQFGKEIGPHVQRKVDAFMTLLETEPFLGMLECVPSYTSVAVYYDILKIAPMIDHGTTAFQVVRKLVSEKLEQM NEGTVKERNVIEIPVCYGGSYGPDLEEVAQHNQLSLEEVVNIHASKEYLVYMIGFAPGFPYLGGMPKRIAAPRRK EPRTLIPAGSVGIAGEQTGVYSIDTPGGWQIIGKTPLSLFRPTAKHPSLLQAGDFVRFQPITEKEFIRLEGEEA Bacillus halodurans NYSGXRC-6067n SGX Pharmaceuticals 2004-11-10 active Selected Cloned Expressed Soluble HI1731 GENBANK ZP_01067487.1 MFSVHFSGSKALLLRFEQEISPQINAYVLSTEQRIQKALKEGEIYGIDELVSAYASLLIYFNPCVLSLNSLLDFLE KIKKDIKLAEQNSSLCIEVPLCYDEEFGLDLEFVCKHNQISKEELISLHTKPYYLVFMLGFMAGFPYLGGLDERL FTPRLSSPRAKIEAGSVGIADKQTGVYPISSPGGWQIIARTPLEFFDKEDEKNPTLLKAGMFLKFKAISKDEFFD IQEQVAKKVYQKEIYEYKNH Campylobacter jejuni NYSGXRC-6067o SGX Pharmaceuticals 2003-01-30 active Selected HI1731 MSITFEIEPIAEGSILVRFQHPADATLAMHIGQCAHDIMQSLAYGLMNVTPSYTTLLIDYLPYRLTQKELVAQLTL LLNQPRQSNHANANLIELPVYYHPDVGLDLIRYQEQGLALAEVIQLHTSVTYTVAAIGFAPGFAFMTQVAEPLRR PRRTTPRLMLPKGSVGIAEQQTAIYPNASPGGWNIIGNCPQTLFDPRQEPMSPWQIGTQVRFRSIERDEFIQLGG VIEPYSIHRA Vibrio cholerae NYSGXRC-6068a SGX Pharmaceuticals 2003-12-13 active Selected Cloned Expressed Soluble PA2579 GENBANK NP_251269.1 MCPCPHSQAQGETDGEAEWHNAALDFTHAMSYGDYLKLDKVLDAQFPLSPDHNEMLFIIQHQTSELWMKLMLHELR AAREHVKSGKLGPALKMLARVSRIFDQLVHAWAVLATMTPTEYNTIRPYLGQSSGFQSYQYREIEFILGNKNATL LKPHAHRAELLAALEQALHTPSLYDEAIRLMAAQGLPVSQERLARDAAAGTCYEASVEAAWRQVYQAPERYWDLY QLAEKLIDLEDSFRQWRFRHVTTVERIIGFKPGTGGTEGVGYLRSMLDTILFPELWRLRSNL Pseudomonas aeruginosa NYSGXRC-6068b SGX Pharmaceuticals 2003-11-05 active Selected EC2014 MSEPIQPTRPAASGCPMHGAQAESWHDAQMDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKL MLHELRAARDCVRNDDLPPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILG NKNAAMLQPHAHQPEHYAQVKAALETPSLYDEAIRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPT HHWELYELAEKFVDLEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVNYLRKMLDVVLFPELWKLRTDL Ralstonia solanacearum NYSGXRC-6068c SGX Pharmaceuticals 2004-02-16 active Selected EC2014 VSGEPSCPFGGPAPEHSAEQAHRDFSRSLSYGDYLHLDELRSAHQPITDAHDEHLFIAIHHVSEVWLSLIVRELQA AMRLLDAGITDAPLKMLTRVVRAQEQLTAAWDVLKTMTPADYLQFRGAFGQASGFQSQNYRMVEFLLGNRNSTLL RPHEHRADLHRPLAAALHAPSVYDLTLRLLAARGLPVPAEVLQRDYAQPYQTNEAVLASWLSVYCDTETYWDLYE LAEKLVDVEDNFRRWRFNHLTTVERTIGFKRGSGGTSGVGYLRGALDVVLFPELWDVRTQL Deinococcus radiodurans NYSGXRC-6068d SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC2014 MAQDMTYARYLALDELLSAQKPLSDRHDELLFIVIHQTKELWLKEILHEVALALKLIAGGDVEPAYKALARVSRIQ TVMTLSWDILATMTPADYLSFRDDLGTSSGFQSHQFRALEYLLGLKDQSFLKFHTERPEALAMLKSALESPSLYD VAIAQLPRHGLTVPDAALHRDFSQTYVPSPEVEAAWLEVYRDPKRYWELYQLAEKLVDLDDALVTWRHKHVLTVE RIIGGRPGTGGTDGVGYLASTLRRRAFPELWSLRTKL Caulobacter crescentus NYSGXRC-6069a SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2257 GENBANK NP_215919.1 MTVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTSGIRRGDRVLDVAAGSGNVSIPAAMAGAHVTA SDLTPELLRRAQARAAAAGLELGWREANAEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVCRRGGKISTLN WTPEGFYGKLLSTIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRFGCPDECRDYFKNFYG PAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC Mycobacterium tuberculosis NYSGXRC-6069b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2257 GENBANK NP_459774.1 MAQVNKQAIAAAFGRAASQYEQHASLQQHSADALLTLLTGRQFASVLDAGCGPGRMSRYWRERGSEVTALDLSLPM LQQARDRQAAHHYLLADIEAIPHDAEVFDLAWSNLAVQWCGDLRDALSELYRVVRPGGVVAFTTLCQGSLPELRQ AWQAVDNRAHANSFLPEEAIDHALRGWRAFRHTQAMTLWFEDALSAMRSLKGIGATHLHEGRESDVLTRARLRQI QLAWPQRQGKYPLTYHLFMGVIERD Salmonella typhimurium NYSGXRC-6069c SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC2257 GENBANK NP_346024.1 MSEAGHKFLAKLGKKRLRPGGKRATDWLIAEGGFSKEKRILEVACNRGTTAIELAQRFGCKITAVDMDAQALEVAK KSAGTAGVAHLISFERANAMKLPYQDASFDIVINEAMLTMQADQAKKKCVMEYLRVLKPGGLLLTHDVLLKEAKE SIRQELSQAIHVNVGPLTQDGWEQVMIESGYCDVKALTGEMTLMKLSGMIYDEGLLGTLKICVNACKKENRKQFL TMYKMFAKNKQKLGFIAMASYKSSKR Streptococcus pneumoniae NYSGXRC-6069d SGX Pharmaceuticals 2004-03-31 active Selected EC2257 MKCRISTVCWRCCMATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRER HAQVTALDLSPPMLAQARHKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAF TTLVQGSLPELHQARQAVDERPHANRFLPPDEIEESLNGVRYQHHIQLITLWFDDALSAMRSLKGIGATHLHEGR DPRILTRSQLQRLQLAWPQQQGRYPLTYHLFLGVIARE Shigella flexneri NYSGXRC-6069e SGX Pharmaceuticals 2004-03-31 active Selected EC2257 MYELYTLLAEYYDTIYRRRIERVKAEIDFVEEIFKEDAKREVRRVLDLACGTGIPTLELAERGYEVVGLDLHEEML RVARRKAKERNLKIEFLQGDVLEIAFKNEFDAVTMFFSTIMYFDEEDLRKLFSKVAEALKPGGVFITDFPCWFYG GRDGPVVWNEQKGEEKLVIMDWREVEPAVQKLRFKRLVQILRPNGEVKAFLVDDELNIYTPREVRLLAEKYFEKV KIYGNLKRELSPNDMRYWIVGIAKSF Pyrococcus horikoshii NYSGXRC-6069f SGX Pharmaceuticals 2004-03-31 active Selected EC2257 MPTFHEIDVLRHNSASWDAQAARDCEWSRPVSAEEVAAARRGDWAVKLTPGALPAHWLGDVRGREILCLASAGGQQ APILAAAGARVTLFDASAGQLDKDRQVAARDRLELACVQGDMRDLSTFADASFDLVFNPISNLYVDDVLPVWREC ARVLRPGGKLLASFYNPALFIEDRSPELAEQGLIRPRHRLPYSDLESLSAEALAAKREKGEALVFGHSLTQQIAG QLAAGLLLQDFYEDWQPHPRFVIDRFVPTFLATCALKPRSAAG Pseudomonas aeruginosa NYSGXRC-6069g SGX Pharmaceuticals 2004-02-02 active Selected Cloned Expressed Soluble EC2257 GENBANK NP_905958.1 MKQKNAYNRLTNHYDDVLTGRKWWSWLYMHCLWKTDDNIIAGSVLDMIPGNFEGRILDVPVGTAIFTYDKYRRMPQ AEIVGLDYSQEMLDIAAMRFSAEQITNVSLRQGDVGSLPFPDAAFDLVLSMNGFHVFPDKDRAFAETFRVLRGGG LFCGCFYVKGERKPADWFVRKFLDKKGLFRPPHYTREEAIEKLRSLYGDNVEIQDARSLLVFKCTKPR Porphyromonas gingivalis NYSGXRC-6069h SGX Pharmaceuticals 2004-01-08 active Selected Cloned Expressed Soluble Purified BSU19600 ICEDB: T1748 GENBANK NP_389841.1 LSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGCGTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKR FANEGLAIPAYQAELEHLPFSSESFSCVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQM MDFYGFTCLHEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQLYSEYMGH CIFIAYK Bacillus subtilis NYSGXRC-6069i SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed EC2257 GENBANK NP_248247.1 MCKAFCSCYSYHYHHREKMGIKEYYDKLAKSYDKLYKNKYMRIVEREIIQKEIKDGDFVLDIGCGTGEQLKILNNA VGLDISLEMAKIAKNKTNKPVVVANAEFLPFKNKSFDKAISFFGALNHCNLKRALREVNRVLKDDGIFIFTVANI YDIKWIIKNILKGNFKKVKNAMKKRKGTITKVIDGEKIKVKTRFYDFKEVEDALKKEGFEVVYTFGTNITNSPLD KFIYKSFLKNFASYIGFVAKKVKNR Methanococcus jannaschii NYSGXRC-6070a SGX Pharmaceuticals 2003-11-05 active Selected EC2252 VSVERKYDRFAALYDKFESFIEKKFFSRFREELFKRVEGKKILEVGIGTGKNVPYYSDDMDVVGVDISEGMLRVCQ ERLKKFPEKKVKLLRADVQNLPFSDGEYDCVVSTFVFCTVPDPVKGLKEVHRVLRPSGKAVFLEHMRSRKWYVNV ILFLMHIFTKLLLGTSMLRKTVDNIKKAGFVIEEEKYLLSDVVRLIIARKGSEESD Thermotoga maritima NYSGXRC-6070b SGX Pharmaceuticals 2003-11-05 active Selected EC2252 MKNYQKFAAVYDSIMDDSLYDKWTDFSLRHFPKNKKKLLELACGTGIQSIRFKQAGFDVTGLDLSADMLDLAKKRA QSAHLDIPFIQGNMLDLSSVGKFDLVTCYSDSLCYMEDEVAVGDVFEQVYAHLNSGGTFIFDVHSTYQTDEIFPG YAYHENTENFAMVWDTYRDEAPHSVVHELTFFIQDNDGRFTRYDEVHEERTYDLLTYDILLEQVGFKTVKVYADF TDDIPKEDSKRWFFVAEKREK Streptococcus mutans NYSGXRC-6070c SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2252 GENBANK NP_279815.1 MNTAPDTGTERATYTWSAGRYPSLAPNLLPAIARLVSACGVDPGNTVLDVGCGTGNAALTARRAGATVTGLDVTRS MLELARDTTQLTDYNDISWVAGDASTLPFPDDAFDVVLSSFGHVFSPAAAEAGREMLRVAQPGGRVAFTAWSPDG LVGALTDVLDDYVGHDDHDPWAHLRWGNPEFVRDHLGDACELTFERRIARFRYVSPEHFWRNFAEEAGPLSPALR ALDDPGARSALREDALATLDEWFADNTVRVEYLLARGVVDGAA Halobacterium sp. NRC-1 NYSGXRC-6070d SGX Pharmaceuticals 2004-01-28 active Selected Cloned Expressed Soluble EC2252 GENBANK NP_148241.1 MRRGCGGISTAPLFDRLYERYDKWYEENRLLAANEAKTVSRALEGSPRPLLEVGVGTGFFASIVGADAGLDPSLGM LRRARERGIPLLVAGVGERMPFRSRVFGSALIVVTLCFADDPQELLREVWRVLAWGGVLVSCIVPRDSSWGEYYE AKGRAGHPFYSKARFITNEMHHTMLKNAGFSLERQYATLSFKPWEEPREEEPVEAWGGDYGFTCTRARKKHVI Aeropyrum pernix NYSGXRC-6070e SGX Pharmaceuticals 2004-02-16 active Selected EC2252 LTGGGPTMANWYERNILPKLLCCACGAPAIQAQRRRVAPRAEGEVLELGIGGGLNLAYYDPTKAKRVTGVDPSPEL RAIAEQAPRPDGLVVDIQAGEAERLPFADASFDTVLCTFTLCSVRSPKAVLAEARRVLRPDGRFLFCEHGLSPDA EVSRWQRRLEPLWKRMAGGCHLTRPVASAVAAAGFALDEVEQRYMPKTPRPLGWCEWGVARLA Caulobacter crescentus NYSGXRC-6070f SGX Pharmaceuticals 2003-11-05 active Selected EC2252 MIVFRRFPTCLLHHIRQPASRSLLLESQRRSLSFTSYKYNSSHIDDDKSKKKLKNVFQMNSNRVIRKQKTKEELAK ERFEEQLRSPNRFVRWGAIARSEKFSKGMTKYMIGAYVIFLIYGLFFTKKLFAKDKELERLLKKQEEGNANEYEA LRIKELKGKLRRRDELKLEEYKKMQEEGIENFDDIRVQNFDQNKLNEQILPARDTTNFYQEKANEYDKAINMEER VIFLGKRRKWLMKHCQGDVLEVSCGTGRNIKYLDMSRINSITFLDSSENMMEITHKKFREKFPKYKKVAFVVGKA ENLVDLAEKGKPSLENEKENQVKYDTIVEAFGLCSHEDPVKALNNFGKLLKPDGRIILLEHGRGQYDFINKILDN RAERRLNTWGCRWNLDLGEVLDDSDLELVEEKRTHLGTTWCIVAKRKGDVKKKDELGFVEKYLQSSIRKRMESFE KKDDMASKKELEPVPPVSKS Saccharomyces cerevisiae NYSGXRC-6070g SGX Pharmaceuticals 2003-11-05 active Selected EC2252 MRLFKKFISNCRRPENNFWGKMMLAGMNYGHNKMALWCIDECIRPSGEEDILDIGCGGGQNIANFLTRTKGKVCGA DYSAQSVAKSVARNRKAVRDGRAEIMKALVSSLPYESATFDLATAFETIYFWPDIVEDFKEVRRVLKPGGRFAVC NEMASEAGNERWISLLDMKIYTPDEIVENMTKAGFTQTSVFTQGNRICVIGR Porphyromonas gingivalis NYSGXRC-6071a SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed EC2260 GENBANK NP_216039.1 VGSAGVPAADAGGRDAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVGKLTTKY FLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGASYIARN LGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFRGFLAEVARVLRPGG HFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDL RRGGGFSYRIYLFAKD Mycobacterium tuberculosis NYSGXRC-6071b SGX Pharmaceuticals 2004-02-03 active Selected Cloned Expressed Soluble VNG2147G GENBANK NP_280804.1 MRVQANSRSMGVLEDKARARTFYKYLSKVYDRVNTFIWTEEMRAEALSMLDIDAEDRVLDVGCGTGFGTEGLLKHT EHVYGLDQSPHQLTKAWEKFGKHDPVAFHFGDAERLPFKPDSFDVVWSSGSIEYWPHPVQGLRELRRVAKPGSQV LVVGPDYPASTVFRKLADAIMLFYDEDEADRMFREAGYEEIQHRVLRKEPNSPPAIVTVARAPAADD Halobacterium sp. NRC-1 NYSGXRC-6071c SGX Pharmaceuticals 2004-01-20 active Selected Cloned Expressed Soluble Purified Z0233 ICEDB: T2190 GENBANK NP_285898.1 MTTQSHHDHVEKQFSSQASEYLTSTVHASGRDLQLLAVCLADYPDASVLDMGCGAGHASFVAAQNVSTVVAYDLSA QMLDVVAQAAEVRQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMDVMSP GHPVRDIWLQTVEALCDTSHVRNYASGEWLRLINEANLIVDNLITDKLPLEFSSWVARMRTPEALVDAIRIYQQS ASTEVRTYFALQNDGSFTSDIIMVDAHKAA Escherichia coli O157:H7 NYSGXRC-6071d SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2260 MSGLPQGRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHD VGAALREVNRILKPGGRLIVMDVMSPGHPVRDIWLQTVEALRDTSHVRNYASGEWLTLINEANLIVDNLITDKLP LEFSSWVARMRTPEALVDAIRIYQQSASTEVRTYFALQNDGFFTSDIIMVDAHKAA Escherichia coli NYSGXRC-6071e SGX Pharmaceuticals 2004-01-07 active Selected Cloned Expressed Soluble Purified EC2260 ICEDB: T1749 GENBANK NP_594470.1 MAEQIDLKTFKTDVADYEAARPEYPIGITDWITDEFLIDETSIILELGAGTGKFTPRIIASHPKEIIAVDVYPEML DVLRKKFPNVDCRAGSAMAIPLEDESVDLVLCAQCFHWFANEEAMKEIYRVLKPNGKLGLVWNTRDDTVPWIEKV SKILGRYRKDAPSFVSWKWAELFPGHGFGKLRYCAFPFSRCLTVEELHTLMNSFSFIYKLPEEEKEKVHAELDEI AKTIPRVQNTDQIKLCYQTMAFSSEKEPAK Schizosaccharomyces pombe NYSGXRC-6071f SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed Soluble EC2260 GENBANK NP_069348.1 MGILEDKKRARIFYRYFSKIYDYINPIFYSDKMRKTVVDMADIDAESLVLEVGCGTGFTTEEIVRRIGEERVVAVD ITPEQMMKARAKMGGVNYFLGDAENLPFKDNSFDAAISAGSIEYWPNPQRGIEEMARVTKSGGKVVILAPRKPDN FAVRKFAESIMLFPSTQQCVYWFMKAGLEDIRFVETGPYRFWSKLVVIISGTVP Archaeoglobus fulgidus NYSGXRC-6071g SGX Pharmaceuticals 2004-02-18 active Selected Cloned Expressed Soluble Purified EC2260 ICEDB: T1674 GENBANK NP_275022.1 MGGKMSDKKYNVDEGEIAKFSRIADKWWDKSGEFKTLHDINPLRLDYIDGHADLCGKRVLDVGCGGGILAESMARR GAAFVKGIDMAEQSLETARLHAALNNVADIEYECIRVEDLAEAEPHSFDVVTCMEMMEHVPDPAAIVRACANLVK PDGMVFFSTINKNPKSYLHLIVAAEYLLKFVPKGTHDWKKFIAPAELARMCRQAGLDVADTKGMTYHVLSQTYAL CDSTDVNYMFACRPAF Neisseria meningitidis NYSGXRC-6071h SGX Pharmaceuticals 2003-12-09 active Selected Cloned Expressed EC2260 GENBANK NP_298776.1 MSESSEKTGTTHFGFRQVAAKDKKTLVAEVFTSVSRRYDLMNDLMSLGIHRAWKRYFVATAQVKSGDRVLDLAGGT GDIAMLLKNRVGAEGSIVLGDINASMLSVGRDRLIDRGVVAHLDYVQCNAEALPFQDKCFDLVTMSFGLRNVTDK DTALCEMFRVLKVGGQARVLEFSTVTAEWFKPIYDFHSFQVLPRLGRLFARDAASYRYLAESIRKHPPQEELQAM MGAAGFERCRYRNLTGGIVAIHSGYKY Xylella fastidiosa NYSGXRC-6071i SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2260 GENBANK NP_422502.1 MSNTSASFGFKDVDASLKAGLVRGVFDRVAKNYDIMNDLMSGGVHRLWKDAVAARLNPQPGEVIIDCAGGTGDMAR RFAKMARKAQERRGGPDATINIVDYNAEMIMAGIERGGEPEITWTVGDAQRLPLPDAYADAYVISFGIRNVTDIN AALREARRVLKPGGRFLCLEFSRPVTEPLAKAYDAYSFKVIPQVGEWVAKDRDAYQYLVESIRRFPDQRTFAGMI EAAGFKRVTFTNFTGGVAALHQGWAI Caulobacter crescentus NYSGXRC-6071j SGX Pharmaceuticals 2003-11-05 active Selected EC2260 VYRRKPNPYVKLINGDKIIDVGCGSGQNCDQFKGRLVICLDLSLNQLNQARKKGCQNLVQADMEYLPFRDSSVDSL AYIASLHHLRDPSQALGEAQRVLKDKGEILVTVWLVQLKFFFLRRYIIKRSLINGKEVRRFYRLYYPWELKRIME SKGFVTKIYKLYRVNSLLPNNSLYYGIKSTA Sulfolobus solfataricus NYSGXRC-6072a SGX Pharmaceuticals 2004-03-31 active Selected EC2253 MLSPPAAVPGESFVGIYDRYVLPRLIDFACGMGDVMKQRSLLVPRAHGRVLEIGLGTGLNLGFYDAAKVSAIVGVD PAAQMQALARERAAQIGIPVEMVALELGEIRAEAESFDTIVCTFTLCSIAAPLPALGEMRRVLKRGGELLFCEHG RAPDASVLAWQRRLTPWWKPLAGGCHLDRDMPALLREAGFRIDELEQGYLPGPRPMTYVYRGVAR Pseudomonas aeruginosa NYSGXRC-6072b SGX Pharmaceuticals 2004-11-16 active Selected Cloned Expressed Soluble EC2253 GENBANK NP_596661.1 MGILKKTIFIGGIYGLGVYIGAVAWRLRKDVLNYESRQKSDLLIPNSNSISIYNQIADKYSRKITREEIFSGIYFL RYFLLRNAKGDVLEVGSGPGTNFPFYKWKKINTLTLVEPAEKMREIADARAKKKVPPNVLYRQFADLRQLPPNQS YDTIIQTFCICSQEKAVEQLNNYRSLLRSDGRILLIEHGKGKYKFLNRILNAYAESHYESWGCVWNRDIEQLLED SELTIDSCKRFNFGTTYVIEAH Schizosaccharomyces pombe NYSGXRC-6072c SGX Pharmaceuticals 2004-06-29 active Selected Cloned Expressed Soluble Purified EC2253 ICEDB: T1758, T1907 GENBANK NP_241687.1 MSYLELLATLGIGSAHPGGFALTKQLLAHEKLTNESRLLDIGCGTGKTLEYIQQMYDCELNGVDIHPVMVEKAKQR FQEKELNIPIQQGNVEQLTFKDNTFDFILSESVLFFTSMNRALSECARVLKKTGSLLGIEMMALKPLDVFTSEEL TKVYGVNHLPTEKEWMTTLTNNGFSHMDVLKRGNVQEARPDESEAPDWMPSAIDDELFSTLQQHQAFLDIHGSSI GYFVFRAKK Bacillus halodurans NYSGXRC-6072d SGX Pharmaceuticals 2004-01-29 active Selected Cloned Expressed Soluble Purified EC2253 ICEDB: T1754 GENBANK NP_354064.1 MKQNIYDDAGFFERYSAMPRSIEGLRQAGEWHELRAMLPDLKGRSFLDLGCGFGWHCRYAAEQGAARIVGVDLSEN MLRRAAEINGGPGIDYRRAAIEDIDFPRESFDVVLSSLALHYVRDLDAAFAKIFAVLKAGGDFVFSIEHPVFTAL EKQDWFYGEGGEILHWPLDNYQNEGVRHSNWMADDVVKYHRTVSGILNGLLSAGFALTQLAEPRPDPALMAERPE LKHEDRRPIFLIVGAKKP Agrobacterium tumefaciens NYSGXRC-6072e SGX Pharmaceuticals 2004-03-31 active Selected EC2253 GENBANK NP_269645.1 MVTKEVGHDFLARLGKKRLRPGGVEATNWLIEQGQFSQDCHVLEVACNRCTTAIELAKTFGCQIDAVDLNPKVVKE AQERVAVEGLTRHITVSQASALSLPFPDNHFDIVINEAMLTMLNAQAKEKALNEYWRVLKPGGRLLTHDVAYEDP KTRQVLDELRQTIHVNVAPLSLTGWQALYQEHGFSQVTYHHGKMSLMTPRGMIKDEGLMNTLNIMRRGLKKENRQ QFLKMRRFFTRTGKNLCYIAVKSVK Streptococcus pyogenes NYSGXRC-6072f SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed EC2253 MKIMGFYSQVILPRLLDWSLSDPTLATYRQELLTDVTGEVLEIGFGTGLNLAYYPSHIHKITTVDVNPGMNTIAQK RIDDSGIKVQQLLLSGENLPMADNTFDSVVSTWTLCSIANVEQALQEVYRVLKPGGKFFFLEHGLSNKPNVQVWQ NRLTPIQKVLADGCHLNRNIQQLVEQSFDHVELKRFTPENFPDLMAHFYKGCATKKSI Nostoc sp. NYSGXRC-6072g SGX Pharmaceuticals 2004-03-31 active Selected EC2253 IFLNTIESQFDKVAEDYDFVNELLNDYSFFVSNMSPKKGRALDIGCGSGLLVEKLASYYDEVVGIDISNQMLDLAK SKRQLTNTVYLNMNAEQLNFNEKFDFIVSRTTFHHLDDIASVIQQMKELLNEEGRIVILDNVSEVETPPTYVYKL GAIQEFLPHCFKFGIKNAIRIYNHNTSKSWLEHLASDKYLSEQNYYDLYEKLLPGCQFHKMGWAMGVVWTK Staphylococcus aureus NYSGXRC-6072h SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2253 GENBANK NP_215663.1 MTSGAAASASRVDHPLFARIWPVVAAHEAEAIRALRRENLAGLSGRVLEVGAGVGTNFAYYPVAVEQVIAMEPEPR LAAKARIAAADAPVPIVVTDKTVEEFRDTETFDAVVCSLVLCSVSDPGAVLAHLRSLLRRGGELRYLEHVASAGA RGRVQRFVDATFWPRLAGNCHTHRHTERAILDAGFVVDSSRREWAFPAWVPLPVSELALGRAHRT Mycobacterium tuberculosis NYSGXRC-6072i SGX Pharmaceuticals 2004-01-28 active Selected Cloned Expressed Soluble EC2253 GENBANK NP_068979.1 MITVLILRCIMVKSTTRKSAKSDRRRYNRIARFYDLFETPMELMNFRKWRKMLFDLIKAEKGLVLEIGAGTGKNIP HYPSNVVALDISEKMLERAVRRAKESGKKVDFLLADAENLPFRSNSFDVVFTTFVFCSVDDPVRGLREAFRVLKK GGRAYFLEHMLPKSRFLHPLFNLLNPIFRAFGPEINRRTDENIQRAGFQIVKEYMLFGSVFRLIVAEKPLDSVDE ASGYSLKRSESSDSSNFRRFIGQSLLPLRLTQLLR Archaeoglobus fulgidus NYSGXRC-6072j SGX Pharmaceuticals 2004-01-12 active Selected Cloned Expressed Soluble PF0738 GENBANK NP_578467.1 MEIRAFSKYRKRALSLVRGKVLEIGVGTGKNLPYYPKDVEVIGIDFSRNMLKKAEERRRKLRLENVTLLYMDAQDL EFEDNTFDTIVSTFVFCTVPDPIKGLKEAYRVLKPGGRAIFLEHMKSESKLLNVPLYLMEPFIRTLLGTSLLRET QRNIERAGFKIEKVENLFYDIVRLIIATKD Pyrococcus furiosus NYSGXRC-6073a SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2261 GENBANK NP_218246.1 MFVEYTKSICPVCKVVVDAQVNIRHDKVYLRKRCREHGSFEALVYGDAQMYLESARFNKPGTFPLRFQTEVRDGCP SDCGLCPDHKQHACLGLIEVNTHCNLDCPICFADSGHQPDGYAITAAQCERMLDTLVAAEGEPEVVMFSGGEPTI HKQLLEFVDAAQARPVKTVIINTNGIRLASDRRFVDQLATRNRPGHPVHIYLQFDGLDEATHRRIRGHDLRDVKQ RALDNCAAAGLTVSLVAAVERGLNEHELGAVIRHGMAQPGVQPVVFQPVTHAGRHVQFDPLTRLTNSDIIACITA QLPEWFRPGDFFPVPCCFPSCRSITYLLTDGEHVVPIPRLLNVEDYLDYVSNRVIPDLAIREALENLWSASAVPG TDTMTAQLQRATAALNCAEGCGINLPEALTHLTDRVFAIVIQDFQDPYTLNVKQLMKCCVQQITPDGRLIPFCAY NSVGYREQVREQLTGVPVPDIVPNAIPLAGLLADAPHGSKQANTGGSIARLAGPTRGAPMALPPQQIKACCADAY SRDIVALLLGDSFHPGGATLTRRLADQLGLRSTGDPRRVADIAAGPGASARLLASDYGVAVDGVDISEINVKRAQ AAVAQTGLTERVRFHLGDAESVPLPDDTFDALVCECAFCTFPDKNAAAQQFARILRPGGLAGITDVTVGDGGLPA ELTPLAAWVACIADARTVTDYTDILEGAGLRTRHIESHDESLLDMIDRIDARITALHVAAPEILADNGIRHDSVR DFTALARAAVQTGRIGYTLMIAEKP Mycobacterium tuberculosis NYSGXRC-6073b SGX Pharmaceuticals 2003-11-05 active Selected EC2261 MTTQMPIASPRTEFYERAFGGFHDQAVAEVRKETYGEDLGQNDWSTVDEMRQFSQWLELSPQSHLLDVCSGSGGPA LFLARNSGCRVTGVDLHPDALQTGRQLAQALELHDRSQFVECDVRQRMPFPDGTFDALWCIDSVIHIPDRLALLR EWCRLLKPGGRFLYTDPTLVTGMVSKEEILLRGTPGYFLYTPIGLNERLIEQAGLRLDMQADLTHSITELSERWH AAREKRCAVLTATEGEEAFARMQSFLTATHRVSVEGRLSRWVFVGVRP Ralstonia solanacearum NYSGXRC-6073c SGX Pharmaceuticals 2003-11-05 active Selected EC2261 MPDDSSPLLAPHGVAALPDKRQVAASFSRAAASYDAVAELQRGVGESLLSALPEGFSPRRWVDLGCGTGYFSRALE RRFGAAEGLAVDIAEGMLRHARARGGASHFIGGDAERLPLRDGSCDLLFSSLAIQWCADLPAVLAEARRVLRPGG VLAFSSLCVGTLGELRDSWRVVDGFVHVNRFRAFADYLQHAAGSGLLPLTLRHEDRLLHFPDLRSLTHELKALGA HNLNPGRPDGLTGRQRIRALVAAYERFRQPEGLPATYRVVFGVLRKDS Pseudomonas aeruginosa NYSGXRC-6073d SGX Pharmaceuticals 2003-11-05 active Selected EC2261 MATIFRDLSYRYQWLYDSISRVAALTVGGEARFRKLALQGLTIQANTSVLDVCCGSGQATQLLVKSSQNVTGLDAS PLSLQRARQNVPEANYVEAFAEKMPFPDNQFDIVHTSAALHEMEPQQLREIIQEVYRVLKPGGVFTLVDFHTPTN PIFWPGLTVFLLLFETETAWQLLKTDLAGLLTEIGFEAGQSILYAGGSLQVIQAKK Nostoc sp. NYSGXRC-6073e SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC2261 GENBANK NP_341788.1 MAQIVNTERHSRLLPAPSSFEEGVVKFGDKEINIGGPLPTLAKDEKLVRVTHSLCPACYRLLPATIFEKEGKLFIR KICPEHGEFEDLYYADSSLYYKFDYWEYEGKGPKVPYVDLKSPCPYNCGLCPMHHQHSALVNLVITNRCDLSCWY CFFYAEKAGYVYEPTLEQIKFMVDQLKKQDITLVIQVTGGEPTLREDIIEIIKMLRENGVKHIQLNSWGGTFAKL YLEDPDKAIKYARALREAGVNTVYMSFDGTTRKTNPKNHWEIPYTLEVFRRAGMTSVVLVPTVIKTVNDNDLGNI VKFAAYNMDVVRSVNFQPVSLTGMMKRNMRAKFRITIPEVIKNIEEQTDGEITKDSWYPIGTSVVFSRLVEALTG KEQFEMANHPSCGAGTYVYVEWRNHEPHFIPISKFIDLEGLLEYLKEKEEELREGANKVWVASKVLYSIRKFIDK EQGPKDFDVYKMLYNIIIHHNYEALGEWHYRTLFLGSMHFMDLYNYDVQRVMRCDIHYVVPDGRVIPFCTYNVLN DLYRDKVLREYQIPLDKWTKEHGENSLGDAIKYKRIASTLENSEIYKNTYKSFQQM Sulfolobus solfataricus NYSGXRC-6073f SGX Pharmaceuticals 2004-01-29 active Selected Cloned Expressed Soluble MJ0619 GENBANK NP_247603.1 MEKKTLSLCPICLKRIPATILEEDGKIIIKKTCPEHGEFKDIYWGDAELYKKFDKYEFIGKIEVTNTKVKNGCPYD CGLCPNHKSTTILANIDVTNRCNLNCPICFANANKSGKVYEPSFEDIKRMMENLRKEIPPTPAIQFAGGEPTVRS DLPELIKLARDMGFLHVQLATNGIKLKNINYLKKLKEAGLSTIYLQFDGISEKPYLVARGKNLLPIKQKVIENCK KVGFDSVVLVPTLVRGVNDNEVGGIIRYAAENVDVVRGINFQPVSFTGRVDEKTLLEGRITIPDFIKLVEEQTDG EITEEDFYPVPSVAPISVLVEKLTNDRKPTLSSHQHCGTSTYVFVDEDGKLIPITRFIDVEGFLEIVKEKIEEIG KSKMHDVKVLGEIALKLPSLIDLDKAPKSVNIKKIIDLILSVLKSDYSALAELHYHMLMISCMHFMDAYNFDVKR VMRCCIHYATPDDRIIPFCTYNTLHRQEVEEKFSIPLEEWKRMHKIGGEDDREDY Methanococcus jannaschii NYSGXRC-6073g SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed EC2261 MIDTMQYGKNDSLRDEIKAYWSGRAATFDLSPGHEIFSEDERAAWHALILKHLGRGEGRKALDLASGTGVISHLMD DLGFQVTGMDWSETMLGLAREKAKSRGRNIRFFVGDAENTMEPDESADVIITRHLVWTLVDPQASFAEWFRVLKP GGKLLIVDGDFVNTGWRERLVKKLAVSLESIGLVKADQPHKPADPENTFNSILSRVYFSKGARAGDVATMLGATG FEPVSVDQELRAIHRAQAKNFSLLKGILRGLQHRYAVCAVKPDTSVKG Agrobacterium tumefaciens NYSGXRC-6073i SGX Pharmaceuticals 2004-01-22 active Selected Cloned EC2261 GENBANK BAB60102.1 MLSVEKEKYPNIRFASDFEISENAPFKTVDEFVKEMGHLINEDMLVIRVTESLCPGCVDEEKFDQMRIPAIVYEEG GDVKLIKECPEHGITTEKYWEDYEMFEEAKKWQDPGIKLMNPNVAYYASKIVCPTHCGLCVKHKSHTGLGNIVVT NRCDLSCWYCFFYAKENEPIYEPTQDQIRMMLRRMKNEKPVGANAVQITGGEPTMRDDIIDIVRIAREEGYDHVQ LNTNSVRAAFDPDFVRKVREAGSNVIYTSFDGPTPRSNPKNFWEIPDALENYKKAPLGVVLVPTVIGGVNDMYLG DIIRFGLSNIDVVRAVNFQPVSLVGRMPDRARAKQRITIPGAIKKIEQQTDGLIGREDFFTVPSSAAVSNFVAAL KGRPTYKLSIHYACGMGTYLFKDDEKVIPVTRFVDVKGMFEYIQNLADEIEDSTFKSLKKVETTTRLLYNLKKFV DYEKAPKDFKLKDMVYNAFTEGDYHGLKAFHYKSMFIGFMHFQDPYTYDVDRVERCDIHYAMPDGRVIPFCAFNV IPELYRDSTQRKYSIPAKVYEEKTGRSLKKEKYFREYSMEDKKRIIAFYERSIGRKLTEEEIGQKLEDPIPVISS QNPDM Thermoplasma volcanium NYSGXRC-6073j SGX Pharmaceuticals 2003-11-05 active Selected EC2261 MAETLGEVPSGEKEFEASTKHVREIIEFPEMTEEEFNKLLKSASKGYGSPLPHRTYSLCPESRRVVPAVVWEKDGK VWITKKCPEGMITDLYYEDVELYYRFSKWRFEEKKLFSANVSNTGINCPFDCGLCPRHRSHTSLINIVLTNRCNL SCWYCFFYAREGEPIYEPTLEQIRMMLRNAKKEHPIGANAVQFTGGEPTLRDDLIEIIKIAKEEGYDHIQLNTDG IKLAFDPELVKKLREAGVNTLYLSYDGMTPQTNWKNHWEIPLIFENVRKAGGPGIVLVPTLIRNINDHEAGAIIN FGLNHLDIVRGVNFQPISLVGRVPRKERQRFRITIAGAIKKIEEQTNGVIAKEDWYPIPIAGHIARFFEAFTGRK YYMTSHFACGAATYVFLDREEKKVIPIPRFIDVDGFVEFLVEKAEEIEKARFKSLAKLKAIGETIFVKFKQFYDE KNAPKGLDVLGLIKNAFVHGTYDALGKFHMNTLFIGMMHFMDEYNYDVERVERCVIHYAMPDGRIVPFCTFNVIP EIYRDKVQRQFSYSWEEWKKLHPDWDYKKDKYIRTKEFVEKMKKSEVYKKTYIDIVNYFER Pyrococcus horikoshii NYSGXRC-6073k SGX Pharmaceuticals 2003-11-05 active Selected EC2261 MAENLSAGEVPSGEKEFEALTKRMREIIEFPEISEEEFEEMLKNANRGYGEPLPHRTYSLCPESRRVVPAVVWEKD GMVWITKKCPEGIITDLYSEDVDLYYRFLRWKFEDKKLFSVNVPNTGINCPFDCGLCARHRSHTNLLNIVLTNRC NLSCWYCFFYAREGEPVYEPTLEQIRMMLRNAKKENPIGANAVQFTGGEPTLRDDLIEIIKIAKEEGYDHVQLNT DGIRLAFEPELVKKIREAGVNTLYLSYDGMTPQTNWKNHWEIPLIFENVRKAGGPGIVLVPTLIRNVNDHEAGAI INFGLNHLDIVRGVNFQPISLVGRVPKKERQRFRITIAGAIKKIEEQTNGAISRDDWYPIPIAGYIARFFEAFTG KHYYMTSHYACGAATYVFLDKEEKKVIPIPRFIDVEGFVEFLVEKAEEIERARFKGLAKLKAIGETVFIKFKQFY DEKYAPKGLDVLGLIKNAFMHGNYDALGQFHTKTLFLGMMHFMDEYNYDVERVERCVIHYAMPDGRIVPFCTFNV IPEIYRDKVQRQFSYSWEEWKKLHPDWDYKKDKYFRTREFVEKMKNSELYRKTYIDIVNYFE Pyrococcus furiosus NYSGXRC-6073l SGX Pharmaceuticals 2004-11-29 active Selected EC2261 MLRLRQEPPRSFERPLRVSVLRREDGKRYIEIDGRRIGVGGPLPAVREGERLIRYTGSICPYCLRLLPAVIVARGG RLYIRKKCPEHGEIEDLYYGDERFYWRQMKWEETGLGLSGAGPYTTATAPCPYACGLCSLHENHSALVNIVVTNR CDLSCFYCFFYAERAGYIYEPSIEQIKFMVRQVARQRQGSDVHVNIQITGGEPTVREDLVDVVKAIREAGAHYIQ LNTNGINVARRYLDNPPGAIDYVRSLREAGVSVVYMSFDGVTPKVNWKNHYEAPFALKAFQEGGLDNVVLVPTVI RTINDHEVGDIIRFAGKHIDVVRGVNFQPVSLTGMMRKHERERMRITIPDVIKRIEEQTDGQIPMDAWYPVPVVA KFVKAIDALTGKLYDTLSNHPACGSATYVFALERDRYGVPRRFLPITEVIDVEGFIEFLDEERIKLEHNSGRLSR LKVAAEIVWRARRFVDFDRMPRDLDIYKLIVSIFLRKNYEAIKTFHKKTLFLGMMHFMDRYNYDITRVRRCNIHY ALPDGRLVPFCAFNVLEDIYRDNVQKRFAKAKNLRIKGFNPGEKYDRRRYIKRILESPIYREAYRGIIDVDAVAK LPAPSPHGQ Aeropyrum pernix NYSGXRC-6074a SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble EC2281 GENBANK NP_247941.1 MILKEGEVVFEVPDKLTVTKKDEVFYNPRMKTCRDISIAVIQAFLNLYHKRDKFYIADALAGSGIRGLRYAKELEF NGELKVFLNDINPKAYEKIINNAKLNEIENIDVFNEDANTFLSKHFRFFNVVDIDPFGSPAPYVEQAIRALVTRN GLLCLTATDTAALCGRSKKSCLRKYLAYPLFGRDCHEFALRVLVGYVMRMATKYELALKPVFCHATDHYVRVYLV TDRGAKRADKVFEMLGYVKDVNGIKIIKKFEEGYEKGFAGPLYIGNLYDKALVEEALKIAEKREFSERVLKILNA IKGESAINQVGCYDTHQIGKMLKISVPPMQDIINKLKEMGFNAVVTHYNPKGIKTDATLKNVIEAIYQCTKIR Methanococcus jannaschii NYSGXRC-6074b SGX Pharmaceuticals 2003-12-22 active Selected Cloned Expressed Soluble Purified EC2281 GENBANK NP_111255.1 MRITEGSAVIEVPEAYSGPGRRSPGFYNADQVLNRDLTIDLINEFGVEKVLDGFGGSGVRGIRISLETKAKVVIAE ISPSSCEIIKQNIAINNAEADLIHDNFQCVSSHIAFDYIDVDPYGSPVPYLDAAIMNVRKGGYLGITATDQSTLT GSTLNKTRRRYGAYIVNDIYRHEMGIRTLIGYIARRAAAFDRYIEPQLSIWNHHYYRVFVKVGKGVNGADKMIEN IGYLNKHTTIDNSFKDVNEGPVWLSNLNNAELLEKIRDPRVSKKIEMIKHDNRLLFVDLTDIARKTSLSLPPLAK VMDEIMKHGYEAHRTSFSPTGIKTDCPYAEVSEILKAYAKR Thermoplasma volcanium NYSGXRC-6074c SGX Pharmaceuticals 2003-11-05 active Selected EC2281 MSMELFEVHEGKAKVLVPKAKTIYDSPVFYNPRMAPNRDVVVLLLNVLKPKIVLDALSATGIRGIRFALETPAEEI WMNDINELAYELMKKNVLLNFKGTLKENAKRAIFEGEKTIVINNDDANRLMAEKHRYFHFIDLDPFGSPMEFLDT ALRSVKRKGILGVTATDGAPLCGAHPKACLRKYLAVPLRGELCHEVGTRILVGVIARYAAKYDLGMEVLLAYYKD HYFRAFVKLKDGAKKGDETLENLGYVYFDEKTGRFEVEKSFLSTRPNAYGPLWLGPLKNEKVVGEMLELLVSGFE VANYREVLKLLHMLHEELDIPLFYDTHALGKRLKIEPKKLGEIIKELKSMGYEATRTHFSPTGIKTNAPYEVFVE VMRKN Pyrococcus furiosus NYSGXRC-6074d SGX Pharmaceuticals 2003-11-05 active Selected EC2281 MPSLNDPRLDVLVSLGNWLRGQDYRFVTVTPATHERVNARPENRMARDLAGIFGWSRAFAGESLPADWLTLLAGAD LIRREADGWRSQVRVSSLGEQLFVHSAFPTLAADAVFFGPDTYRFDRLIRSHLASSDPARIRRAADIGCGAGPGA IRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQAPGRFDLIVANPPYLLDASERAYRHGGG MLGAGLSLAIVDAALERLEAGGSLLLYTGVAMVEGGDPFLARIRERLASREWDWDYQELDPDVFAEELDSPAYRE AERIAVVGLRVTRSA Pseudomonas aeruginosa NYSGXRC-6074e SGX Pharmaceuticals 2004-02-16 active Selected Cloned Expressed EC2281 GENBANK NP_147490.2 VKLPVPSPMRLAVTHEGRSIIYIPSPEYAVASGRLEPAWLEVFYNPAMEFNRDVSVVAASALRRTGLLTRSGVAFD AHAGVGVRGVRYAVEAGYVKVIMNDINPKASMLAALNARANGLEPGSYMIFNKESNSLMFHLSRERPTPVSLIDI DPYGSPAPFVDAALALSGKGTVVAMTATDLAVLEGGKARAAVRRYMLRSVSKTPVSKETGLRVLLGYVARVAAAH DKAVKPLLAYYADHYYRVYVAVERGARRSDSMLEENLGRLVYCPETGVALALSYAEDPASACGGSYVVAADPAWI GSLGDQAFLEAMLNIAVEAVWLGTRPRVEKLLNTLHGEAPLSPRSIYVSLTSVASKARVNTPKKSKVVELLRSMG YRAVATHFSGEGVRTDAPWGEVLEAVVKLGSSG Aeropyrum pernix NYSGXRC-6074f SGX Pharmaceuticals 2004-02-19 active Selected Cloned Expressed Soluble Purified EC2281 ICEDB: T1679 GENBANK NP_815652.1 MKWTEVKVETASEAVEAISNIMMEAGASGVAIEDALDIENFESDLYGEILDKEQFTHIKEGAIVMAYFPETTFLTE ILPFMKENILRLPEYGLSIGKNEMTISEVAESDWATAWKKYYHPVRVTRFLTIVPSWEAYHAQDEAEKIITLDPG MAFGTGTHPTTRLTLQALETVLRGGETVLDVGTGSGVLSIASRYLGAKDVYAYDLDEVAVAAAKENMDLNPIAAD VHVSANDLLKGIDHSADVIVANILADIIVLMIEDAWRLLKQDGTFIISGIIEDKKAMVLEALTKVGFVVDQLFNQ GDWYAIILKKPEEE Enterococcus faecalis NYSGXRC-6074g SGX Pharmaceuticals 2005-10-26 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC2281 ICEDB: T1750 PDB 2ESR GENBANK NP_269611.1 PFAM PF03602 MRVVSGEFGGRPLKTLDGKITRPTSDKVRGAIFNMIGPYFNGGRVLDLFAGSGGLAIEAVSRGMSAAVLVEKNRKA QAIIQDNIIMTKAENRFTLLKMEAERAIDCLTGRFDLVFLDPPYAKETIVATIEALAAKNLLSEQVMVVCETDKT VLLPKEIATLGIWKEKIYGISKVTVYVN Streptococcus pyogenes NYSGXRC-6074h SGX Pharmaceuticals 2004-01-13 active Selected Cloned Expressed Soluble EC2281 GENBANK NP_213571.1 MEIVQEGIAKIIVPEIPKTVSSDMPVFYNPRMRVNRDLAVLGLEYLCKKLGRPVKVADPLSASGIRAIRFLLETSC VEKAYANDISSKAIEIMKENFKLNNIPEDRYEIHGMEANFFLRKEWGFGFDYVDLDPFGTPVPFIESVALSMKRG GILSLTATDTAPLSGTYPKTCMRRYMARPLRNEFKHEVGIRILIKKVIELAAQYDIAMIPIFAYSHLHYFKLFFV KERGVEKVDKLIEQFGYIQYCFNCMNREVVTDLYKFKEKCPHCGSKFHIGGPLWIGKLWDEEFTNFLYEEAQKRE EIEKETKRILKLIKEESQLQTVGFYVLSKLAEKVKLPAQPPIRIAVKFFNGVRTHFVGDGFRTNLSFEEVMKKME ELKEKQKEFLEKKKQG Aquifex aeolicus NYSGXRC-6074i SGX Pharmaceuticals 2003-11-05 active Selected EC2281 MIVREGSAEILVPEVYHGPGKRGTGFYNADQKINRDITIEFIKKMGIRNVLDGFGGTGIRGIRISKETDSAVTISE VSPDSYRLIRDNVERNGSQASVINDSFECVLQHGAYEYVDVDPYGSPVPYLDAALMGVKRNGFLGVTATDQSALT GSVPHKTRIRYDALIKNDTFRHEMGIRLLIGYMAKRAASLGRFIDPLISIWHGHYYRVFVRVRKGFEGAGRMMQN LGYVNKHNLLSGIYQDMDEGPVWKGNLQDNAVAEAVLASAGHKAFNPEENRLLFCDLTDIARARHTSLPDIESVI DALSSSGHAASRTMFSPTGIKTDASCDLVESLMMDTLHRRSPA Thermoplasma acidophilum NYSGXRC-6074j SGX Pharmaceuticals 2003-11-05 active Selected EC2281 MKLKEVTEGKVRIFVPDPTGYMVEGKFDPSWAPVFYNPKMTFNRDLSVIVVSILKPKIIVDALSATGIRGIRYYVE SWKSEQLILNDKNPNATSLIQINAKNNGIENAKIYNKDANALLYEVKSDYIDIDPFGSPAPFILSSLNAATRNGI VAFTATDLSPLEGSSPTSCRRKYDAINHKLSSSKELGLRVLIGKIIREAAILEKTVYPLFSFYADYYYRLFVRVE NGARKADDNINKHLKYFGECPRCGFQTFVEENCKTKCPVCGEIFSIIGPLYIGPLYSMEFLKRIMDLYSNFNYLT SFNRIQKLLNVIEKEARFKNVFYNISKLASKLKISAIPPIESILECLGDASRTHFAPTGIRTDKEYEEITKCIKS LR Sulfolobus solfataricus NYSGXRC-6074k SGX Pharmaceuticals 2003-11-05 active Selected EC2281 VWTALSQQTNQTTQPTSTLFAMKYIAYAFELTHRPDELTLETAYDLLSAELAEIGFESFEQNETCLRAYIPVSTDI ASDIPALLEQFPLPGLLWQYSSEIQPDINWNEQWEKNFFRPIRIEDKCLVRAPFHPTDPDIPLELIISPQMAFGT GHHETTSLMMSYLLDMDLRGLRVLDMGCGTGILAILARKLGASSVTAIDIDDWCIRNTGENAALNDIRDIDVRIG DASLLADCPMFDLIIANINRNILLDDMSAYRSRLGNGGTLLLSGFYTEDIPILTECAEILGLTLSETRSRNNWAA LRFTPDSPKR Porphyromonas gingivalis NYSGXRC-6074l SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC2281 MEVEEGRARVKVEGVFYNPRMRFCRDLDMLVFATMDSKEYFDALSASGIRGIRAALEAGKKAVFNDVSPKAVKVIE ENLRENGVSGEVINGDAAAVMRQRAFEHIDIDPFGSPAPFMDSACFSAKRYLSVTATDTAALCGSATNSGLKKYG AFAVKTDVYHEVGLRMLIGFVVREATKYEKALFPLISWVREHYYRVHFKIKKSTAMSAKVYEKMGYLAYCSTCLR KKVLGMGEGAERCECGGKFSLIGPIWLGELKQRDFAEKVAEKAEGKLRAFLEKILAEIDAPTAYSLPALAKIHSL TLPPTDVVVEELKKLGYEASRTHYCGFCVKTDADRDVVVKILRSRKII Archaeoglobus fulgidus NYSGXRC-6074m SGX Pharmaceuticals 2004-02-16 active Selected EC2281 MSDLITLAQLSQGYRYNSDSLILADFILKQGIKGAVFDVGAGCGIIGILLKKNIANLSLSLIDIQKENIELIEKNL KSNKIQGDIFHDDFNQFQIIKKFDFIVCNPPFYRQGAYKSEDQHKAISKFQEFLPLHSFLAKTNSMLKPNGTLYF CYEALALDEICFILKDMKMKITKLCFVHTHQSKKARLVLIQVKKGSKSPCEILPPFFVYENEILSKQMQEIHLRF RLKSYDI Campylobacter jejuni NYSGXRC-6074n SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed EC2281 GENBANK NP_280755.1 MDVSEGGVTVSVPTASGGGEGAADDVFFNATQELNRDLTVATLAAFREREPRAASYLDAMTASGIRGVRAANAGWD VTMADVDADAVELATSNLARNGLDGEVVARDANSLLHDHDRVLDVVDIDPFGSPMPFADAAFANARNLVCVTATD TAPLCGAHFESGVRKYSATPRNTNYHAEMGLRILLGALARTAARYDVGVTPILSHVSDHYVRTYLELDHRATDAN AAVEQVGHVYHCQQCLSRDHEYGLVAAPRAECPRCGGHQVLTAGPLWLGPAHEEAFAASVREQLTREMGEASQAF HLLQTIEGELHEPTHYDQHRLYSQWGEPAVGMAEFLDQLRDAGLRASRTHFGGTTFKTDGGLAEVEAAVL Halobacterium sp. NRC-1 NYSGXRC-6075a SGX Pharmaceuticals 2004-03-31 active Selected EC279 MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETVFYNPIQQFNRDLSVTC IKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSPKEAVGNSNRNEPYINILEALSATGLRAIRYA HEIPHVREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAI QSIEEGGLMLVTCTDLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSID FYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSVAQGPPVDTKCKFCEGT YHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPP LKKVVAGLGSLGFECSLTHAQPSSLKTNAPWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSE YDSKLSFAPNEQSGNIEKLRKLKIVRYQENPTKNWGPKARPNTS Saccharomyces cerevisiae NYSGXRC-6075c SGX Pharmaceuticals 2004-03-31 active Selected EC279 MQTLILKPGKERSLLRRHPWIFANAIDRVEGRPASGTTMVVRAHDGRFLARAAFSPTSQIRARVWSFDEAEPIDHA FFKRRIAAAVAYRRDWVRDTDAVRLVMGEADGLPGLIVDQYGTLAAGQLVCQFSATGVEHWKEAIVAALVKETGC PNVYERSDVSVREREGLPQQTGVLAGAEPPADLSATEHGVRYYVDARAGHKTGFYVDQRDNRALVGALARDRDVL NCFCYTGGFSLAALKGGARSVISIDSSGEALAVAERNVALNGFDAARAEWLDADVFKSLRNFRAEGRQFDLIVLD PPKFAASAQQVDRAARAYKEINLVGLQLLRPGGLLFTYSCSGAIDADLFQKIVAGAAADARVTARIQRRLSAGLD HPLLASFPEGEYLKGLLLQVG Ralstonia solanacearum NYSGXRC-6075d SGX Pharmaceuticals 2004-03-31 active Selected Cloned EC279 GENBANK NP_596547.1 MYEANMLRLSQRISNAVNHFSTAMMSGASASLTEGSAIIPFSNPNEVFYNPVQQFNRDLSVTAIRAWSETRSKKIV AKSHHRHQLLDQNSELSQENLTKCDTTHDFEKNCSEKTDSTSADNIAGFTILEALSATGLRSIRYAKELPNVKRI LANDLLENAVKTIEKNVNYNNVSDIVIPNKGDANAVMHMNKFHYDVIDLDPYGSAAPFLDAAVQSVSKDGLLCIT CTDSAVLAGNAYPEKCFSNYGGSSLRSNFCHEQAVRHLLYAIAASAAKYGRAIKPLLSLSIDFYFRVFVQIKAKP VLVKNLQSQSLLIYHCSGCGSFAEQPLGKTSPGRLPGTTKFSNASGPPVSANCEHCGYVHHVGGPLWGGPLHDAE FLKKMRAIAEDLDPEVYGTKRRILGMLALADEELPDVPFYFVLSQICSVLRSQSPPQNIFVSALLNAGYRVSGSH AKSNAIKTNAPWSFVWDVLRSWIKDHPVKLENISKTSAGAAILEKTPTAEVDFTFRPDSEFASKKEGYTRYQMNP TENWGPKSKPGKRTIAEVDSKS Schizosaccharomyces pombe NYSGXRC-6075e SGX Pharmaceuticals 2004-01-08 active Selected Cloned Expressed Soluble Purified CAC1435 ICEDB: T1747 GENBANK NP_348063.1 MKLMRKNETREFLIEDIEFPAVGVAFYNDKKVYIKGAVPGQKVLARVSKVRREKIEAKLKEIVTNIPGAAQPKCPD FGVCGGCVHQFLPYEKQLEFKEREVLKLFKDAKIEGFEYLGILGSPEKEEYRNKMEYTFGDFVKGGELTLGMHAK NSGFSIVNTDKCNIVDEDFRIILKTVVEYFRKKDLPIYKVMQHVGYLRNLVVRKAKNTGEILIALVTTSQVDFDL TELTEILKSINYLGELKGILHVINDGLADMVRGDKIVTLFGQDYITERILDLKFKISLFSFFQTNSKGAEKLYSE VLEFLGDVSNKTVFDLYCGTGTIGQLASKKAEKVIGIELIEEAVEAAKENTKLNNISNCSFIAGDVAKVITEIKE KPDTIILDPPRPGVSPNAMKYVIKFNAPEIVYVSCNPKTLVNDLGVLRAYGYEVEKVKIVDMFPGTGHVETVVLL QRKII Clostridium acetobutylicum NYSGXRC-6075f SGX Pharmaceuticals 2004-03-31 active Selected EC279 VVNLELIEVQEGKAKILIPKAESIYDSPVFYNPRMALNRDIVVVLLNILNPKIVLDALSATGIRGIRFALETPAEE VWLNDISEDAYELMKRNVMLNFDGELRESKGRAILKGEKTIVINHDDANRLMAERHRYFHFIDLDPFGSPMEFLD TALRSAKRRGILGVTATDGAPLCGAHPRACLRKYLAVPLRGELCHEVGTRILVGVIARYAAKYDLGIDVILAYYK DHYFRAFVKLKDGARKGDETLEKLGYIYFDDKTGKFELEQGFLPTRPNAYGPVWLGPLKDEKIVSKMVKEAESLS LARKKQALKLLKMIDQELDIPLFYDTHAIGRRLKIETKKVEEIISALREQGYEATRTHFSPTGIKTSAPYEVFIE TIKRI Pyrococcus horikoshii NYSGXRC-6075g SGX Pharmaceuticals 2004-03-31 active Selected EC279 MTNTTLNFQNASGHEVLAAVGKKYLRPGGRIATEQLCQWANFQPNETVLELASSFGYSAISLAQRYGVKVVGVEKN PESVVLARENVRVAGLENQIEIIEGDIFHLDAIPGKFDYVLAEAILTMQSPSGKAKLLAGIYNRLKAGGKFLSHE LLANDKEEQIRADLARVIRVNSTPLSEANWIAACETAGLKVEKHQIGSMNLLNLWRMFQDEGIFPTIQILVNVLT HKSIRERVLAMRHIFNKYRHELGYIILYAVAEEHN Nostoc sp. NYSGXRC-6076a SGX Pharmaceuticals 2003-12-18 active Selected Cloned Expressed Soluble Purified ECs3447 ICEDB: T1741 GENBANK NP_311474.1 MNDEMKGKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRPGKSRADGGRRPARDDKQSQPRDRKWEDSPWRTVSRAP GDETPEKADHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPEAIVRAWFIQSVTPRFKEALRWMAANR KAYHVVDEAELTKASGTEHHGGVCFLIKKRNGTTVQQWVSQAGAQDCVLALENESNPHNLGGMMRSCAHFGVKGV VVQDAALLESGAAIRTAEGGAEHVQPITGDNIVNVLDDFRQAGYTVVTTSSEQGKPLFKTSLPAKMVLVLGQEYE GLPDAARDPNDLRVKIDGTGNVAGLNISVATGVLLGEWWRQNKA Escherichia coli O157:H7 NYSGXRC-6076b SGX Pharmaceuticals 2004-01-12 active Selected Cloned Expressed Soluble EC2299 GENBANK NP_457123.1 MNDELKNKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRPAKSRTDGGRRPARDERNNQSRDRKHETSPWRTVSRAP GDETPEKVDHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPDAIVRAWFIQSVTPRFKEALRWMAANR KAYHVVDEAELAKASGTEHHGGVCFLIKKRNGTTVKQWVKQAADQDCVLALEDVANPHNLGGMMRSCAHFGVKGV VVQDAALLESGAAIRTAEGGAEHVQPITGESIVDVLDDFRQAGYTVVTTSSDRGQALFSTTLPEKMVLVLGREYD YLPEAAREPDDLCVKINGTGNVESLNVSVATGVLLAEWWRQNKA Salmonella typhimurium NYSGXRC-6077a SGX Pharmaceuticals 2004-03-31 active Selected EC2303 MVGGALICKYLPREEQLKLISDLIQNDSLEEVLELIETSPLDITTDSNIETPIFEKITEQVIAYASIDGEAREMFR SSRAEMNKALRTSAQLLCCLPSVWHKFQVWMSYRLNDIISENYKHLFNDNFGKKIVQPFFDSFAEEQNANIKHEN LHLDILSLLHYLEVVYLFDECKNGISSKCLDFIIVPLLGCNSEEIADSCSKLMRWHIKYLSKCCNTDSNFDKLIW TFIKQLYAEGSQQAWKQKNSLSFLLRFLLAAELSPELITYIKTDAYWRHIQTELDNDVHEHRKLALSILKLTIQK LSSHGITLQTTFYKCNDLANIEMLGSWKKFTTLYEMIALDTSLNQIQAAKQDIIKIFDNEHLHHSWGLILLSTGL KSSMESVRKYMMTLMFSITNMSAFSSNLPLLTKTLLPAAMSAHYFDVKGVSCPHGEKLSLFVNNLLSQTTEGISD ILFEILKLLVEKGTSFDPSRIYLSYGILVFFQNNKQKTINSDHLSLIRKLYDFAAEEEVLETTIQTIYLKFLLYI DPSVSASELLFTLVSHIKLKGGTYKYVEPLFEDYRDLAVSHFDDLQAKENLTTNIGKDTIFDLLASIIFDFKDID ITPDFLIEVAKSKQDIPVYTSKAVTFLTQLLSGEPSNGYTYENATALLSYPNFTISTWKSINVNNLFKSVMEKFS LDKFKFFAEIYQKTYECRFDTIELNFNDLLSLYEMVKKSANQCSRESFKVKDSAYSSYFELLNTFLKTYALNRDS SEGNDDELHILLRLVDENINKDNGNYLGNLAVCKLLYFIIDSYIHCSTSVSDDDIFIVKFIFEKFSFIWECINSE RLVLKERDLHLMLIKGLFHPVILYFGSNQYIDTLTSKLEEHAQTIISLSYSRRSLLPLLGSQLRVFMKFYGKLLR EDVNYWWLINIIVGVFKQPQMDVNLYKLKPVISSLFDHKLNNYYIKGDELYEKVYGPDEILARVSIIDSILYAND QLKIRLIEKVTEKTNALYAIKRTDGAEALQRLLQWQLLLLSLLTTNEKKLSETSMIRILKSIEDESSPLVRVYKE WFISSKVVDYYKTGNPKFAEDYLFSLLEDHSKPVFVVSAEKICFMVLKDLRNDEKKYGFTQLLDRFICTLVPNAA SNKPLVRHFSNSLIISLWPTFKAYLSDHTLRNIIENLYSNAKKTQIFGQYRAGDANIWDLKGDRKLTNMFGGVLK KVTDHDCPYISESVFEKYLQEKDIVPIGTDERSLWLDKRDTNTESVNNANISCDTSPLQTKSGAWETVLDLDNKK SNDVVTRSELIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASF MKEKKKEGYTLIGLEQTDKSVKLDNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAV IVHSYTVQHM Saccharomyces cerevisiae NYSGXRC-6077b SGX Pharmaceuticals 2004-03-31 active Selected Cloned EC2303 GENBANK NP_596131.1 MQRASTQDVYDGSGDDLNKLDSLKSVLNDVLSSLERFQVDLDVATSDIYKVSERSNKIQVNLNNLKAVESALGAEI DGAILPPDLIKTISTGDMDHPSWNSALEKLTSFLEGGEDDSSLGNMFNSLQINKDQKKLVDKLRDKAIERIRNYI VVTIKMFRQAFVDVFPIRKHRLIANKNYYLFLFKFNRKLALELQRAYINTMNWFYLYHFEQYSRFLDKVHVLKGE TIRVEEDRKGLFNLSKGAQQSYGNQMLSVNLRPQDFDMNSVLTASTMHHIESSPQYIERVYCSWELVLTEHVSSE YAFLLEYFNLSKDQQATVFAAIFEKTLHFSRKYITGLISSSIDCIGILKSIRFTQKLALQAQTNIVPVIEPHYNS MILFLWPRFQAVMDMHCESLRKTNLSVKPEEITSRPHPLSQRVAELLYSLSMLSVNVVEAEPVARSASRLAQDYV SMLQNLCKTVNDKRRQSRFLSNNYTLISTVLSGVSGNLAIEQKTYFEKLNENLTNFQ Schizosaccharomyces pombe NYSGXRC-6078a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC2306 VLLRDGDARNVVDAYRYWTREAIIADIDTRRHPLHVAIENFGHDANIGSVVRTANAFAVHTVHIVGRRRWNRRGAM VTDRYQRLCHHDSTTGLLEFAAGAGLTVVAVDNVPGAARLEQTALPRECLLLFGQEGPGITDDARAGAAVTVSIA QFGSTRSINAGVAAGIAMHAWIRQHADLGRAW Mycobacterium tuberculosis NYSGXRC-6079a SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble Purified EC2312 GENBANK NP_417265.1 MAQFYSAKRRTTTRQIITVSVNDLDSFGQGVARHNGKTLFIPGLLPQENAEVTVTEDKKQYARAKVVRRLSDSPER ETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKHDVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKA GSSDIVDVKQCPILAPQLEALLPKVRACLGSLQAMRHLGHVELVQATSGTLMILRHTAPLSSADREKLERFSHSE GLDLYLAPDSEILETVSGEMPWYDSNGLRLTFSPRDFIQVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFT LPLATQAASVVGVEGVPALVEKGQQNARLNGLQNVTFYHENLEEDVTKQPWAKNGFDKVLLDPARAGAAGVMQQI IKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAMLDMFPHTGHLESMVLFSRVK Escherichia coli NYSGXRC-6079b SGX Pharmaceuticals 2004-05-06 active Selected Cloned Expressed Soluble Purified EC2312 ICEDB: T1852 GENBANK NP_588543.1 MPEDYWSAKDYQRNASFVPKLTKDIVKRINLSSSDELLDLGCGDGVLTNELVSQCRRVVGIDASPDMIKAARELGL NAYVIPGEKLLDASEIPSESFDVVFSNAALHWIMRQPKNRPIVMKGVSRVLRTKGRFVAECGAFGNVSEVVGSIY SILLALGATKEQIDQANPWFFGSEDDYTRMLEEAGFHVEYVENISRPTLLNKDVREWLDTFAQHFYHAFPQWKDI IRETVYNALLVTDCRSDGKWFLQYRRLRFVAHKE Schizosaccharomyces pombe NYSGXRC-6079c SGX Pharmaceuticals 2004-05-06 active Selected Cloned Expressed Soluble Purified EC2312 ICEDB: T1908 GENBANK NP_269456.1 MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVNKNSGFGKVEAYHYLSS ARNADVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGISDVTVESTIGMTEPLAYRNKAQVPVRRVNGQ LETGFFRKHSHDLIPISDYYIQDKEIDRLINFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTT RPKVFRVDQVIEKIVEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMAE KLYQTAIAFSDLSKDDIVIDAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALNGITNAYFVADTAEHAM ATWAKDGIKPSVILVDPPRKGLTESFIQASVAMGPQKITYVSCNPATMARDIKRYQELGYKLAKVQPVDLFPQTH HVECVVLLIKE Streptococcus pyogenes NYSGXRC-6080a SGX Pharmaceuticals 2005-04-19 active Selected Cloned Expressed Soluble Purified EC2308 ICEDB: T2201 MSRPQFDPSAYAAQLEDKKSRLAGLLAPFAAPAPEVFESPREHYRLRAEFRLWRETGNEKRHYAMFEQGDKHTPIL LEDFPIASRRINELMPRLKAAWADPALGFKLFQVEFLTTLAGDALITLCYHRPIDDAWRQAAEKLAAELGVNLVG RSRGKRIVVGRDYVEEELSVAGRRFRYRQPEGAFTQPNGEVNQKMLGWAYEALGQRDDDLLELYCGNGNFTLPLA TRVRKVLATEISKSSVNAALANLADNAVDNVSLVRLSAEELTQALNEVRPFRRLADIDLKSYAFGSVFVDPPRAG MDPDTCELARRFERILYISCNPETLAQNIAQLHDTHRISRCALFDQFPYTHHMESGVLLERR Pseudomonas aeruginosa NYSGXRC-6080b SGX Pharmaceuticals 2004-02-19 active Selected EC2308 MTKSTWHQGELIEVAIADLSDTGDGVGRFAERVVFVPDTVPGDRVLVRLLHVKPNYAHGKLHQLLEPSPHRIRPGC IVADKCGGCQWQHIDYEYQLIAKRHQVIQALQRIGGFAQPPVDPVLVTASSLGYRNKATYPLDVSATGQVQAGYY QKGSHHVVNLNQCPVQDPRLNPLLAQVKQDIQQRDWPIYDEKRHQGQIRHLGLRIGRRTGEILLTLVVKDGNLPG IEQQAQEWLQRYPQLVGVSLNRNPERTNAIFGRETRCIAGVPYLREIFAGLEFQVRPDTFFQVFTETAEALLQVI ESQLNLQGHETLIDAYCGIGTLTLPLSKQVRQAIGLELQPEAVQQAIVNAQHNGINNVEFQVGAVEKLLPKMGII PDVVLLDPPRKGCDRIVIESLLASKPARIVYVSCKVATLARDLKLLCTDGTYTIQRIQSADFFPQTSHVEVAAFL VLSQSGKDN Nostoc sp. NYSGXRC-6080c SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed Soluble Purified EC2308 ICEDB: T1756 GENBANK NP_213375.1 MKVFLKKGKEKKVKHFYPWVFRDEVEKIEGEGIVAELYDSEGNFLALGTYSPYSRIAFRVLSYEREEVNEEFFKRR LRESELLRRDIPSNAYRLAFSESDLLSGLIIDRYGDAFVIQVRSYPMEILKEKVLKTLVEEFNPAFVYERSDFKG RREEGLKEFKGLLYGKLENPLIIEEREFKFLVDVVEGLKTGFYLDQRDNREYVRNLVKEGDRVLDLFCYSGGFSV YCANRGAKVVGVDINKRAVELARENAKLNSVKADFVLGNAFDFIQESKEEWDLIIADPPAIAKTKKEKESILWAI WKLAYYSFQKLKKGGSLFICSCTYQISSEEMIRQVRLASTDVKRRIIIKSLNLQPIDHPYLPTFPESLYLKCLHA IVID Aquifex aeolicus NYSGXRC-6080d SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed Soluble EC2308 GENBANK NP_281992.1 MSLENFGNFLTLDEKHSFIKKYFKEFYTKDFKLFASKDKHYRTRAELSFYHENDTLFYAMFDPKSKKKYIIEYLDF ADEKICAFMPRLLEYLRQDNKLKEKLFGVEFLTTKQELSITLLYHKNIEDIKSNLENLSNILHINLIARSKGKKL IFKTENLRQTLNIQDRKIFYEFNNDCFIQPNTAINEKMITWVCEILNTQKRMDLLELYCGYGNFTLALAPFFFKI LATEISKSNINFALKNCELNNTTNIHFARLSSEELSLAIKKEREFFRLKDIRLDDFNFSHVLVDPPRAGLDKSVI DLIKKYGNIIYISCNPMTLKENLKELSLTHRVEEFALFDQFVNTPHLECGVFLSKV Campylobacter jejuni NYSGXRC-6080e SGX Pharmaceuticals 2003-12-18 active Selected Cloned Expressed Soluble Purified EC2308 ICEDB: T1745 GENBANK NP_229812.1 MATLDVNPELYQAQLADKIARLKAMFVDYSMPELEVFESPVANYRMRAEFRIWHEGDDMYYIMFNQETREKYRVDQ FPAASRLINDLMPLLMDAMKGSPILRHKLFQVDFLSTLSGEILVSLLYHRQLSEEWITAAQALKQRLNDEGFNLN LIGRARKMKVVLDRDYVVENLQVNGQPYVYKQVENSFTQPNAKVAEKMLEWAVDCTQESKGDLLELYCGNGNFSL ALAQNFERVLATELAKPSVEAAQFNIAANQIGNVQIIRMSAEEFTQAMEGKREFNRLKDAGVDLQSYRCNTIFVD PPRSGMDIDTCKMVQGYERILYISCNPETLQENLQVLGETHQVVRFALFDQFPYTHHMEAGVMLERKK Vibrio cholerae NYSGXRC-6080f SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2308 MRSLAVVVPKPDSQRAIDGLEDEGVYDDRRKVREHDADHVELPVTAEPDAVPFERAIAQADPDPRAPDLGDRLRER GWSAAERERAPSSWAVLGSVILADFTDCPRPGEVGAALLELHREADTVLDRGDGVAGEHRTPDVSVVAGDGDTET VHVEHGTRYALDLAAVMFSPGNKAERARMGDATGPGERVLDMFAGVGYFALPMARAGATVTAVEKNPTAFRFLAE NAQLNDVAETLDTILGDCREVDAPADRIVMGYYDALGGGPVGDAASTPGYLDAALDNLVSGGVLHAHSAVPEAEL WERPLSRLRAGCQRAGRPAPTVLDTRRVKSHSEGVFHVVIDARVP Halobacterium sp. NRC-1 NYSGXRC-6080g SGX Pharmaceuticals 2004-11-29 active Selected EC2308 MTPEHLPTEQYEAQLAEKVARLQSMMAPFSGLVPEVFRSPVSHYRMRAEFRLWHDGDDLYHIMFDQQTKSRIRVDT FPAASQLINTLMKAMIAGVRDNHALRHKLFQIDYLTTLSNQAVVSLLYHKKLDEEWREAATALRDALRAQGLNVH LIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALEVTKDSKGDLLELYCGNGNFSL ALARNFNRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKRYQCETIFVDPP RSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHTVSRLALFDQFPYTHHMECGVLLTAR Salmonella typhimurium NYSGXRC-6080h SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed EC2308 MSDTQWLEWGRKNPYYGVYSEDRFNTSNIELTKSEFFETGEANVSWMLGRAEQHFGPLGKGRVLEFGAGVARMSIP LASRFEAVVGVELSPDMRAEALKNCQLYNVSNVEMVPSDDDLSHAEGEYDLVLSYIVLQHMDARRGVLLIDKLLS KVGPNGVAILQTSVRRPERRLADRLRYYLRHNVPALAATYRFLRGKGWSTLSMRMSEYDPIAILAAFSRNGMKDV LLSQHYQGDVLTFHFTARKGG Agrobacterium tumefaciens NYSGXRC-6081a SGX Pharmaceuticals 2003-11-05 active Selected EC2309 MARNKGGLRFQPSGGARGPAIPVGKKQRLTIERLAHDGRGIAHEAGMTWFVSGGLPGEELEARVLGARSKVVDARS ERLFSSSDLRRREPCTVAGRCGGCTLQHLEHGEQLALKQRTLQEQLQRFAGIEPEEWAAPLVGPEFGYRRRARIA VRWDARARRLDVGFRASASQEIVAFDECLVLVPPLQTIARALPALLQDFRKPESIGHVELFHGTASALLLRHTTA LVDEDRQRLAAFCSAHQAQLWLQGAEQPLPVEPAAELGYSLGDWQLTLAYRPGDFVQVNAPVNESMIRQALDWLA PTADERVLDLFCGLGNFSLPLARRVARVVGVEGVAAMVERAGANALANGLGNAHFFQADLSKALAEAPWAEQGFT AVLLDPPRDGAFEAVREMSSLGARRVVYVSCNPATLARDAGEMARQGYRLKRAGILDMFPQTAHVEAMALFEAG Pseudomonas aeruginosa NYSGXRC-6081b SGX Pharmaceuticals 2003-11-05 active Selected EC2309 MRGIIEDLSQDGLGVINGIEVPFCYPGDEVRITRTRDRFGRKMASEFSLITPSPLRQRPRCRHYGKCGGCLWQGMK YEEQLKFKKELFRRITGIEAEILGSPRIWEFRNISNFIVSVNGIGLKEFARPKTVVDLKECPVFSNRTPLYIRAM KEFLRESGLKPWNWKEGDVHYLQVREGKFTGEVMVNIIAHRPPEETILEYFPFADSVYWSIKRDKRDDPSGEPIH LGEKEFISEKIFGIKYLLRPGIFFQTNSYALPLLLKAVEGFLDGSKVLDLYSGIGTFSLYLTKKGFNVVGVEINK TAVEVAKLSAELNSLNVEFKAKRAEEENIEGYDALILDPPRKGLGEFAGVVEKKGPENVVYVSCNPKRFILDFKN YLSRSYKVEDAILIDMFPHTPHVEAVIKLRKYS Pyrococcus furiosus NYSGXRC-6082a SGX Pharmaceuticals 2004-01-22 active Selected Cloned Expressed Soluble EC2319 GENBANK NP_286625.1 MQCALYDAGRCRSCQWITQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLH RDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSETKLAQL RKALPWLQAQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALVERFNDVPLWIRPQSFFQTNPAVASQLYATAR DWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIALEAIACAKQSAAELGLTRLQFQALDSTQFATAQGEVP ELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVLTLLVKM Escherichia coli O157:H7 NYSGXRC-6082b SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble Purified EC2319 ICEDB: T1675 GENBANK NP_420917.1 LNDLGVTEDRVLGGRVRLRQAPDGYRPGMDAALLAATCDALPGQRVLEPGCGVGGALLAAATRRPEAIFQGVERDE TAASLAAENVALNGLTSRVAIAQGDVEAGFRALGLPVFDAVMANPPYFDDPSALRAPSPAKSGAWMADGGLAAWT AFCLKAVREGGTITLIHRADRLADILSLLAPKAGSFRIRPVAPFADAAAKRVIVRAIKTGKAPLVLLPPLVMHDR DGGKHSAQAEAILRGEADLAW Caulobacter crescentus NYSGXRC-6082c SGX Pharmaceuticals 2003-11-05 active Selected EC2319 MQCALYDAGRCRSCQWITQSVNEQLSAKTADLHRLLAGLPVEQWCAPIGGPEQHFRNKAKMVVSGSVEKPLFGMLH RDGTPVDLCGCPLYPASFDPVFSALKPFIARAGLTPYNVARKRGELKYLLLTESQFDGGMMLRFVLRSETKLTQL RAALPWLRAQLPQLRVITANIQPVHMAIMEGETEIYLTDQQALAERFNDVPLWIRPQSFFQTNPTVASRLYATAR DWVGQLPVRHMWDLFCGVGGFGLHCATPQMQLTGIEIAPEAIACAKQSAAELGLTRLHFQALDSTQFATAQGETP DLVLVNPPRRGIGKPLCDYLAQMAPRFIIYSSCNAQTMAQDIRHLPNYRIQRVQLFDMFPHTAHYEVLALLRRSI Salmonella typhimurium NYSGXRC-6082d SGX Pharmaceuticals 2003-12-02 active Selected EC2319 MQCEFFIQKRCTSCHLCAQPYSEQVTNKDQQLRELIAPATDVQWLPPVTSADTAFRNKAKMVVLGAAHAPILGIED AQGQPLSLVTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRFVARSHAVLERI ERNLPTLIAAFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQLYATAR TWVREIAPTQMWDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAP ELVLVNPPRRGLGSELTAQLEALAPKYILYSSCNPQTMVKDIAELSSYQMIRVQWFDMFPHTDHAEVLTLLVRK Vibrio cholerae NYSGXRC-6082e SGX Pharmaceuticals 2003-12-18 active Selected Cloned Expressed Soluble Purified lmo1703 ICEDB: T1744 GENBANK NP_465228.1 MNQNPVEEGQKFPLTIRRMGINGEGIGYFKKAVVFVPGAITGEEVVVEAVKVRDRFTEAKLNKIRKKSPNRVTAPC PVYEACGGCQLQHVAYSAQLELKRDIVIQSIEKHTKIDPTKLKIRPTIGMEDPWRYRNKSQFQTRMVGSGQVETG LFGANSHQLVPIEDCIVQQPVTIKVTNFVRDLLEKYGVPIYDEKAGSGIVRTIVVRTGVKTGETQLVFITNSKKL PKKREMLAEIEAALPEVTSIMQNVNQAKSSLIFGDETFLLAGKESIEEKLMELEFDLSARAFFQLNPFQTERLYQ EVEKALVLTGSETLVDAYCGVGTIGQAFAGKVKEVRGMDIIPESIEDAKRNAEKNGIENVYYEVGKAEDVLPKWV KEGFRPDAVIVDPPRSGCDQGLIKSLLDVEAKQLVYVSCNPSTLARDLALLAKKYRIRYMQPVDMFPQTAHVETV VLLQLKDK Listeria monocytogenes NYSGXRC-6082f SGX Pharmaceuticals 2004-05-05 active Selected Cloned Expressed Soluble EC2319 GENBANK NP_593095.3 MNKNEELDEDELLKKCIICPPVPKALKKYWNNRYNLFSRFDEGIWLDYQSWYSVTPEKVAVAIAKSVVDFIQPELI IDAFSGCGGNTIQFAKYCPVISIEIDPIKIAMAKHNLEIYGIPSSRVTFIQGDVLDTFK Schizosaccharomyces pombe NYSGXRC-6083a SGX Pharmaceuticals 2003-11-05 active Selected EC2327 LQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIY YERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQ RSHDIIDMESCLIQDSQHQEVMNEVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMIIFVTNGKKWPQKN AVVEKILDAFPNVTSIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIE YAQLTGNEVVLDTYCGIGTIGLYMAPHAKHVYGVEVVPSSIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGI KPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDALLLAEKYQLEEVTPVDMFPQTTHVETVALFN LK Staphylococcus aureus NYSGXRC-6083b SGX Pharmaceuticals 2003-11-05 active Selected EC2327 MYPYCLKYLTNGLRSKQMINFLCIQNILSARTLKICRFRFLPTPSHPTHKMAQETRAISSISEAANKRARKLSKRR AKKPVEEGSSGHVLLLEIENLIEKPVLANVPFERFQEIEVKISYLSSSGDGIGLVCNDQYAVVVPFTLPGDIVKA KLHFLADTYALADFLEVISPSEDRDDTLIKCPYFAKCGGCQYQMLSYDKQLLQKKRVVEKAFQYYSKLDSSLLPA IKDTVGSPLQYNYRTKITPHFDVPKGGTKGPLIIGFQEKGRRRVMDIEECPIATKTINEEYPKIIEDVQSRANTF KRGATILMRDSATEDGKHCVITDHKMIVREQFGDLSFTFPAGAFFQNNNSILEKFTSYVREQLLNPFGRKEHQRP KYFVDAYCGSGLFSVACSKGFLSVIGVEISADSVRYAEENAKRNNVSNATFIVGQAEKIFSSIETPPNETAMVID PPRKGCDQSFLNQLLEYSPYRIVYISCNVHTQARDVGFLLSQEKGRSYKIDEIRGFDLFPQSHHVESILTLTKVV S Schizosaccharomyces pombe NYSGXRC-6084a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2316 GENBANK NP_388683.1 VNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPGALPGEEVVVQATKVQPKFSEGRIKKIRKASEH RVAPPCPVYEQCGGCQLQHLAYSQQLREKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQS GSIIAGLYGLDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFETGEVQVVLV TAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKTVIQEVLGDVSFELSARAFFQLNPEQ TVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMWVADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEH WLPKWTKEGFRPDVVIVDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQT AHVEAVARLVLKSSN Bacillus subtilis NYSGXRC-6084b SGX Pharmaceuticals 2004-03-31 active Selected EC2316 MNLKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYCQITSIRRNFVEAKLLKVNKKSKFRIVPSCTIY NECGGCQIMHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQ NSHYLVELKDCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLV KELVKDFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALD VDKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRAD ALIVDPPRTGLDDKLLDTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKKV Streptococcus pneumoniae NYSGXRC-6084c SGX Pharmaceuticals 2004-03-31 active Selected Cloned Expressed EC2316 GENBANK NP_269662.1 MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLTVNKASKNRVKPACSVY ETCGGCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQ GSHRLVPIDNCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFI GELTKAFPQVKTVALNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKALD VGSKDHIIDAYCGVGSIGFAFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGKAEDIISKWYKQGYRAD AVIVDPPRTGLDDKLLKTILHYQPKQMVYVSCNTSTLARDLVQLTKVYDVHYIQSVDMFPHTARTEAVVKLQKRV Streptococcus pyogenes NYSGXRC-6084d SGX Pharmaceuticals 2004-03-16 active Selected Cloned Expressed Soluble Purified EC2316 ICEDB: T1734 MAAGKHTKHSNRVRIIGGQCRGRKLSFTSADGLRPTPDSVREKLFNWLGQDLTGKTVLDLFGGSGALGIEAASRNA KRVLISDNNRQTVQTLQKNSRELGLGQVQIVFSDGIAYLKTVSEQFDVVFLDPPFAWQDWQILFDALKPCLNPRA FVYLEAGTLPNIPDWLTEYREGKSGQSTFELRVFQVAE Neisseria meningitidis NYSGXRC-6084e SGX Pharmaceuticals 2004-03-31 active Selected EC2316 MNLRVKQKIPLKIKRMGINGEGIGFYKRTLVFVPGALKGEEIFCQITSVKHNFVQARLLTINKKSKFRVRPACPIY EECGGCQIMHLRYDKQLDFKKDLLKQALKKFKPQGYETYDIRATIGMEHPQHYRAKLQFQTRKFGGSVRAGLFKE QSHHLVDIKDCLIQDELTQKIVNRVCQLLDDYNIPVYDERRHFAGVRTIMVRKSQATNQVQLIFVTSKEVNLVGI IRDLTGYFPEIKTVAVNFNSSKSSAIYGQKTEILWGIDSISEEVLDYSFSLSPRAFYQLNPQQTQVLYHQALQAL DVTAEDHLIDAYCGVGSIGLAFANKVKSVRGMDIIPEAITDAKRNAERMGYTNTYYEMGKAENVIPKWYKDGYQA SALIVDPPRTGLDEKLLKTLLTYQPEKMVYVSCNVSTLARDLVQLVKVYEVNYIQSVDMFPHTARTEAVVKLVKR KQNSCSKK Streptococcus mutans NYSGXRC-6084f SGX Pharmaceuticals 2003-12-16 active Selected Cloned Expressed Soluble EC2316 GENBANK NP_232081.1 MARFFQPKKHSTLDTKHQPVTIERLDHQGSGLAFLHKKPLFVDGALPGEEVLIQLTENKSKYARGQLIKVLKPSAE RVAPFCAHYAQCGGCDLQHLDRAGQIHHKQQALSQLMVKFAGQSLALSAPVCSDDQGYRRRARLSLMWDKKTQQL QLGFRRKQSKAIVNVTHCPVLEPSLNALLPDLNALLSEWSQPERLGHVELVKGDNTRVLVLRHLGALIEQDQQRL TDFASQNQLTLYLMLEAGELQHVQGEAPYCEETGSRLSFLPSHFIQVNRAVNQHMVVQALNWLEVSPQERVLDLF CGLGNFTLPLAKQAQAVVGVEGVDEMVQHATHNAKLNQINNVAFYQANLEQDMTSASWAQQKFAKVLLDPARAGA EGIVDQLSALGAKRVVYVSCNPATLARDSQSLLSQGFRLEKLGMLDMFPHTSHLESMALFVKKG Vibrio cholerae NYSGXRC-6085a SGX Pharmaceuticals 2003-11-05 active Selected EC2310 MTGSTEMVPPTMKHTVDNKRLSSPLTDSGNRRTKKPKLRKYKAKKVETTSPMGVLEFEVNDLLKSQNLSREQVLND VTSILNDKSSTDGPIVLQYHREVKNVKVLEITSNGNGLALIDNPVETEKKQVVIIPFGLPGDVVNIKVFKTHPYY VESDLLDVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLPPFDTTVAS PLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKGRPQWRKDTLDIGGHGSILDIDECVLATEVLNKGLTNERR KFEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVTNPRQIVTEY VDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYCGSGLFSICSSKGVDKVIGVEISAD SVSFAEKNAKANGVENCRFIVGKAEKLFESIDTPSENTSVILDPPRKGCDELFLKQLAAYNPAKIIYISCNVHSQ ARDVEYFLKETENGSAHQIESIRGFDFFPQTHHVESVCIMKRI Saccharomyces cerevisiae NYSGXRC-6085b SGX Pharmaceuticals 2003-11-05 active Selected EC2310 MTALPSITLLPNKEESVRRFHPWIFSGAIASISGNPAEGDPVHIFSSKHEPLGVGHYEKGSIAVRMLSFDVDTVLD VSFWEERLSAAFRLRSALGLIRYDDPRSKNTVYRLVHGEGDGLPGLIIDVYGHTAVMQAHSVGMHHARTDIAKAL IATTAGLVDAVYYKSDSTLPFKAGLESADGFLIGSAQAEAEYENGLLFLPDWIKGQKTGFFIDQRENRALLEEYA SGRKVLNMFCYSGGFSLYAMRGGAYKVHSVDSSARAVHLLEKNMALNFAGDDRHESYAADAFHFLDEMAVGAYDL IVLDPPAFAKHRKVLRNALIGYRKLNAVAFRKIAPGGVLFTFSCSQAVSREEFRLAVFTAAASAGRKVRILHQLT QPADHPINIYHPEGEYLKGLVLYVE Porphyromonas gingivalis NYSGXRC-6085c SGX Pharmaceuticals 2003-11-05 active Selected EC2310 MNAADDKTIVREYFNSTGFDRWKRIYGDGEVNKVQLDIRNGHQQTVDSVIGWLKNDGNLAELSICDAGCGVGSLSI PLATEGAKVYASDISEKMVEEGKQRALETLGNAENPTFAVQDLESLSGSYHTVICLDVLIHYPQEKADEMISHLC SLAQSRIILSFAPKTCALTLLKKIGSFFPGPSKTTRAYLHREADVIKILESNGFAIQRKEFTKTRFYFSRILEAT RS Nostoc sp. NYSGXRC-6085d SGX Pharmaceuticals 2004-02-05 active Selected Cloned Expressed Soluble Purified EC2310 ICEDB: T1763 GENBANK NP_111334.1 LSLKGFVKVERRMADRTIKMLQSRGYFDSDYEIRHEGDYVLIPVKDGFTGPVVVKDAEKKPKVIPASGSFDIIGTI AITKKDDVEFAKEILKTHKNIKSVYLDKGVKGKERIRDLVLLAGIDSTVALYRENGCIFKIDVSKSYFSPRLATE RRRLVDSILDGEFIVDMFAGSGPISIEVAKKRRVKIISIDINCAAIESLQESMRLNSLLGTITPICGDARQLIKD IHDADRIIMNHPTDAFSFLPCALEALKYGGHINYYEILNKDDVTKRLADFNFMRLKVFSYHRVHSYSKLSDLISF DLIREG Thermoplasma volcanium NYSGXRC-6086a SGX Pharmaceuticals 2004-03-31 active Selected EC2315 MLEQVRIQKMVNGGYGLAHLSNGKVVLVEGAYPGEEVLIKTYREKRDFSFGKVVSLLKESEDRIKPPCRYFGRCGG CHWMDVKYETQLRYKKEVLIDLFERSNLKVEVEDVEPSDLVFHYRTKMEFHFQGRKLGLKKRNSDFVIDIKDCEV APEGTGEILNTVKEAVQVLNVPVYNWETRKGVLKHLVIRYAFSTDQFMVIFVTKTESFPWGRDLVRAVLKRFPKI HSIIHVMNSKDSVVLRGPYKTLYGEGVIVEEFDWERFQIPPTAFFQSNYSITSKLIDHVYREQALQGNEVVLDLY AGIGTFSVRTSFSAARVISVESSRVAVKAGKANANINSRKNIEYVEQDVLDFLKNYSGRADRIILDPPRSGAGPE VMKEIARLSPERIVYVSCDPSTLVRDLKVLVENGYSIVRVKPFDMFPQTYHVETAVTLVKGDR Thermotoga maritima NYSGXRC-6086b SGX Pharmaceuticals 2004-02-18 active Selected Cloned Expressed Soluble Purified EC2315 ICEDB: T1676 GENBANK NP_420139.1 MQDLTINAIGAQGDGLARTADGKPAFVPLTLPGEVVRAKMDGARGEVVEILAPSPERVAPACRHYGVCGGCALQHW AAEPYRAWKAEQVRLQLSMEGLETEILPTFAAPPASRRRVALHARKGGKGQGARLGFKERRSWNLVSIEECPVTD PRLVAALPALARLAEPFLEHPKSAPTLHVTLTATGLDIDITGVERKSGGLSADARMRAAMAAGEGDFARVTLAGE TIYGARQPLVKLGQAVVALPPGSFLQAVPAAEKAMVELAVAEAQGASRVADLYCGVGTFTFPLAEVAQVYAAEMS APAITALKAAIGGAPGLKPITAEARDLVRRPVLSTELAKTDVVVIDPPRAGAAEQTVEIAKSKVAKVLGVSCNPQ TFAKDARVLVDAGFKLVRVTPVDQFVWSPHIELVGVFTR Caulobacter crescentus NYSGXRC-6086c SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed EC2315 GENBANK NP_439119.1 MIDCRYYQQNECRSCQWLEIPCSQQLTEKQYHLKQQLISINYDEAQWVAPFQSNQQGFRNKAKMVVSGSVERPILG ILKNPNDPQSAIDLCDCPLYPTHFSAIFSILKDFIGRAGLVPYNIAKQKGELKYILLTESIATEKLMLRFVLRTE NKLPLIRRELPKLLEKLPHLEVISINLQPQHAAILEGEQEIFLTEQQFLPENFNGIPLFIRPRGFFQTNPKVAAG LYATAQQWVAEFPIYNLWDLFCGVGGFGLHCAKALQEKWGKPIKLTGIEISSSAILAASHSAKILGLEHVNFQSL DAASVIENKNENKPDLVIVNPPRRGIGKELSEFLNQIQPHFILYSSCNAMTMGKDLQHLTCYKPLKIQLFDMFPQ TSHYEVLVLLERKKIN Haemophilus influenzae NYSGXRC-6086d SGX Pharmaceuticals 2004-03-31 active Selected EC2315 MRGVVKELNDDGFGVLGNVLVPFSAPGDEVEILKIEKVKKAKIASKWKLIKSSPLRVGARCKVFGRCGGCSLQHLS YDYQLEFKGERIRRLLGVDVEVIPSPRIFGHRNRIDLAVTVEGIGFRERGKWWKIVDIQECPVFGKTSRKAIERL REFIEEERISVWNVKKDEGFLRYMVLREGKFTGEVMVNLVTKEGKLPDPSKYFDFATSIYWSVNRTKSDVSYGEV ESVWGREFITEKLDDVIYLIHPNSFFQTNSYQAVNLVKKVSELVEGERVLDMYSGVGTFGIYLAKRGFKVVGFDS NEFAIEMARKNAKINKVDAVFDVATDREVEVNGFDTVIVDPPRVGLHPKLIKKLNREKPEVIVYVSCNPKTFARD IEKLEYKIDEIVALDMFPHTPHLELVAKLIV Pyrococcus horikoshii NYSGXRC-6086e SGX Pharmaceuticals 2004-03-31 active Selected EC2315 MPVAGPLEIVSLDNEARGVGRLSNEDGTPGKVVFVEGALPGERVTYRSHRAKPSYEQATLVDILRQSASRVTPQCR FFGTCGGCSMQHLDSRAQIAIKQRVLEDDLWHLAKLRPDVVFRPIAGPDWGYRYRARLTVRHVAAKGGVLVGFHE RKSSYVADMTSCEVLPPHVSALLVPLRELVGRLSIVQRMPQIEVAVGQDVTALVLRILEPLTSADEAELRAFADR HAVQFWLQPKGPDTVYPFYPLDRALTYTLPEFGITMPFKPTDFTQVNHQINRVLMSRALKLLDARPGDRLLDLFC GIGNFTLPMATRGCEVMGIEGSEALTTRALANAQHNGLDGKTTFACRNLFEVSADDIAALGRFDRWLVDPPREGA LAVSKAVAELSQRGGEAAALLPGRIVYVSCNPATLARDAGLLVHEAGYRLAGAGVVNMFPHTSHVESIAVFERA Ralstonia solanacearum NYSGXRC-6086f SGX Pharmaceuticals 2004-01-29 active Selected Cloned Expressed Soluble Purified EC2315 ICEDB: T1670 GENBANK NP_353759.1 MSTQTVTIKSLGAQGDGIAHCPDGPVYVPFALPGETVAIAKVKDQGTVMSITEASADRRDPVCRHFGPEGINGTCG GCSLQHLADQPYHAFKRELVVSALRSKGLTPPVDDLVICRPGERRRAVFAARKTEKGLLLGFSQANSHHIVAIEE CPVTSPGIVSRFDAIRAIGLSMVANAEPFRITVLETLSGLDISVEGIKSVNDKQRRTLTETVLAMRGIARVSLSG EILIEPQKPIIEFGGIPVSPPAGGFTQATKQAEDAMAELMLAHVGKSKRIADLFCGSGTFALRLARIGRVHAVEA EDKALKALDFAARNTQGLKPVSVEKRDLFRRPLMTSELKNYDAVVFDPPRAGAEVQCKELARSTVKKIVAVSCNP LTLARDLAILTEGGYRVTRVTPVDQFLWSPHVEAVAVLEK Agrobacterium tumefaciens NYSGXRC-6086g SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2315 GENBANK NP_461878.1 MAQFYSAKRRVTTRQIITVKVNDLDSFGQGVARHNGKALFIPGLLPEESAEVIITEDKKQFARARVSRRLNDSPER ETPRCPHFGVCGGCQQQHVSIALQQRSKSAALARLMKHEVNDIIAGAPWGYRRRARLSLNCPPDKPLQMGFRKAG SSDIVNVEQCPVLAPQLAALLPRIRACLASLHGTRHLGHVELVQAGSGTLMILRHTAPLSAADKEKLERFSHSEG LSLFLAPFSEILETVSGEAPWYDSHGLRLAFSPRDFIQVNEAVNQQMVARALEWLDVRAEDRVLDLFCGMGNFTL PLATRAASVIGVEGVPALVEKGRENAIRNGLHNVTFFHENLEEDVTKQPWAKNGFDKVLLDPARAGATGVMRHII KLKPIRIVYVSCNPATLARDSEALVNAGYEVTRLAMLDMFPHTGHLESMVLFERM Salmonella typhimurium NYSGXRC-6086h SGX Pharmaceuticals 2004-01-14 active Selected Cloned Expressed Soluble EC2315 GENBANK NP_069538.1 VSLKELLKDRLSEEELKLVRRSFEIIGDVVIIEIPDEIMHHSRDIVEAILKRHKHVKTVLRKVGEVDGVYRVARYE PIYGEKTETVVREHGCRFLVDPTKAYYSVKLSGERERIARLVGEGERVLVMFAGVGPYPIVIAKLARPREVVGVE LNPHAVEYFRQNVRLNKVEGVVKVIEGDVEEVVPQLSGQFDRVVMPAPYSAENFIHLLRGKVRRGGFVHYYTFDS QNEEKILPEKVRRKFEDEGLEVEVVKMRRCGNFAPYVNRYVLDLRVL Archaeoglobus fulgidus NYSGXRC-6086i SGX Pharmaceuticals 2004-01-08 active Selected Cloned Expressed Soluble Purified EC2315 GENBANK NP_299637.1 VARQNRFDRTSFQTQIIDLSHDGRGVARPHGEGDKVTFVTGALPGEVVIVEPVARNRHFDEARVVEVLQASPQRVI PRCSHFGVCSGCVLQHLAEDAQVVSKQRVLLESLERIGRVSPERVLPALAAESWGYRRKGRFSVRWVEKKGRTLV GFREHDPRFVADVSVCHTVVPQVGEKIALLATLLNSLDGRRDVPQIEFIAGDAVVALTVRHLQPLSEADRLALIE FGKEHGIAIFLQSGGVESVRLLWPDEVLLAFRLKPWDVEFVFRPLDFIQINGGLNEKMIAHALDLLGAGFGERVL DLFCGLGNFTLPLARTVDEVVGVEGDIGLVERARENARRNGLGNAEFFVADLTRDQRDAPWMRQGFDKLLLDPPR SGAIEVLKQLPLKMFERIVYVSCHPGSLARDADFLVNEQGFVLRAVGAMDMFPHTAHVESIAVFDRC Xylella fastidiosa NYSGXRC-6086j SGX Pharmaceuticals 2004-01-20 active Selected Cloned Expressed Soluble Purified EC2315 ICEDB: T1752 GENBANK NP_465276.1 LEASLLKKNQSIELTIEDLTHDGSGVGKIDGYPFFIPNTLPGEKVTAKIIKLNKNYGFARMENIETVSANRVEPPC AVYSKCGGCSLQHLSYDGQLEFKRNQVEETMKRIGKLNVEVPETLGMENPWRYRNKSQVPVGFVNGKLTAGFYQK RSHAIIDMSTCLIHNEQGDFAVQKTREILAKYGTEPYDEQTGKGDIRHIMTRFAHTTGQLMIVLVTTKERMPFKE EIVRDLVEQLELTSIVQNINPHKTNVIFGDRTKTLWGKDIIEDTIHGIRFAISARSFYQVNPLQTEVLYQQAIDA AELTGEETVIDAYCGIGSISLCLAKKAKHVYGVEIVDQAIQDARANAELNELANTTFETGKAEEVIPSWYKAGIV ADVLVVDPPRKGCDEKLLETILAMKPKKVVYVSCNPGTLARDMKILTDGGYVAKKVQPVDMFPMTTHIEAVTVLH LN Listeria monocytogenes NYSGXRC-6086k SGX Pharmaceuticals 2004-01-14 active Selected Cloned Expressed Soluble EC2315 GENBANK NP_347162.1 MEKVIPVKKNNDYEIYIDDFGNMGEGIGKIDNFTVFVKDAVKGEKVRAKIIKVNKSFAIGKLIDIIEKSQDRTEPV CSIYKKCGGCQLQHLKYTEQLEFKKNKVVECLKRIGKLDLSSVRINETIGMEDPYFYRNKVQLPVGETAGEAKIG FYRERSHEIIEVDKCFIQDDSANEIILLIKRWIKEFNIEGYNEYSGKGTLRHIMIRKAFKTGQIMLVLVTNTENV PHKKELIHMITTEIQGIKGIIQNINNKKTNVILGQREITLWGESTIEDYIGEFKFNISSKSFFQVNPIQTEKLYS AALKYAGLTGKEVVFDAYCGTGTISLFLSQNAKKVYGVEIIPEAIENAKINAKQNGIENTEFIVGKSEEEIPKLI EKGIAPEVVVVDPPRKGCEKSLLHSIAEASPKTIVYVSCDPATLSRDLGILSELGYEVNEVQPVDMFPMTGHVET IVLIKRVDK Clostridium acetobutylicum NYSGXRC-6086l SGX Pharmaceuticals 2004-01-29 active Selected Cloned Expressed Soluble Purified EC2315 GENBANK NP_213177.1 MKDKPLKLTVEKLVYGGYGFSRLNGKAVFVRFASPKELVEAKVVKEKKDYTEAVVTKVLISSPARRKAPCPYYGEC GGCQIQHLNYEEQLRSKKDILLESLERIGKIKEVPYEGEIPSKKEFNYRVRVQFKIQENRVGFYRWDVKEVVDVE ECLLAHERINELIPHIREVLKVIKDLQEVHVNYSPTRDEATLKFVTITHTDEKLLQNILENVLPEWVVGIGDYGK VGNSLVKRYKVGREHIFMDVGKWQYRVSNDSFFQVNYTLWEDFLKEVLDFSESYKKGLDLHCGVGFFTIPLSEQG NFIEGADANPSAIKDAEYNAKINNRDNVIFEEATAFKHLKRRIGEVINLVVVDPPRSGLLREERDLLLKNKPDKI VYISCNPTTFARDLKILTKGGYELKRLKLIDNFPQTYHIESIALLEVKD Aquifex aeolicus NYSGXRC-6087a SGX Pharmaceuticals 2004-01-20 active Selected Cloned Expressed Soluble Purified EC2317 ICEDB: T706 GENBANK NP_388555.1 MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEEKAQIKVTRVKKGFAFGRLIELKEESPHRTDAP CPIYKQCGGCQLQHMTYEGQLLFKQKQVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAG FYQQRSHDIIDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIVFITRTSDF PHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLIGDVKFAISARSFYQVNPEQTKVLYD KALEYAELQGEETVIDAYCGIGTISLFLAKQAKKVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWY EEGITADTLVVDPPRKGCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVEC CVLIKLKE Bacillus subtilis NYSGXRC-6087b SGX Pharmaceuticals 2003-11-05 active Selected EC2317 MLKKNDIVEVEISDLSHDGAGIAKVDGLVFFVDNALPTEKIRMRVLKVKKNIAFGKVESYLAKSAYRSDNLTVDYL RTGIADLGHLTYGQQLNFKRKQVINSLSKIAGISDIEVADTLGMDNPTAYRNKAQVPVRRVNGQLETGFFRKNSH ALMPIEDYYIQDKEIDRLINFTRDLLRRFDLKPYDEKEQTGLIRNLVVRRGHYTGQIMLVLVTTRSKIFRIEQMI EKIISEFPAVKSIIQNINDRNTNAIFGSEFRTLYGEDTIEDTMLGNRYIISAQSFYQVNTVMAEKLYQTAIDFSD LTPDDTVIDAYSGIGTIGLSFAKKVKDVYGVEVIEAAVRDAEKNAALNNITNVHYVADSAEKAMASWSKRGIKPD VILVDPPRKGLTESFIEASTAMQPRKITYISCAPATMARDVKLYEELGYKLVKVQPVDLFPQTHHVECVALLVKA Streptococcus mutans NYSGXRC-6087c SGX Pharmaceuticals 2003-11-05 active Selected EC2317 VEITDLAAEGNALCRIDDMVMFVPFAAPGDRCTVQVVKKKRNFMQGRIVSIESPSPIRKGPFCTHFTVCGGCKWQH IPYEIQLRAKEQQVTDALVRLGKVEVEEMQPILGSEQTEYYRNKLEFTFSNKRWLLPEEVQEVDGDFSPEVRYGL GFHIPGMFDKVLDIRECHLGAKVSDEIRLFIREYCMQDPERYPFFDLRNQEGLMRTLMIRTTSTGELMVVVVFFR DDVAAREALLAAVAERFPQITSLLYVINTKCNDTIGDQEVLLYHGREYIEEEMEGLKFKIGAKSFYQTNSRQAYQ LYRIAREFAGLTGDELVYDLYTGTGTIANFVAGQAHRVIGIEYVPEAIEDARTNSLLNGIENTLFYAGDMKDILT NDFIEQHGRPDVVITDPPRAGMHESVIDAILFAAPRRIVYVSCNPATQARDLALLMADGRYRAVKSRPVDMFPHT HHVENVVLLVRNTE Porphyromonas gingivalis NYSGXRC-6087d SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2317 GENBANK NP_578901.1 MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGARCKVFGKCGGCILQHI NYNSQLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNAIGFREKGKWWSVVDVEECPVFGKTSKKAIER LREYIEEEKVSTWKIREDSGFLRYMVLREGKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGD IEKYWGKEFIMEELDGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGFD SNAFAIEMANKNAEINNVEAEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHGPETIVYVSCNPKTFKV NIEQLNNYIIEELIALDMFPHTPHIELVGKLRRLV Pyrococcus furiosus NYSGXRC-6087e SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble Purified EC2317 GENBANK NP_438497.1 MVLLYTPKQKTKNVQTITADILDLDYQGLGVAKINGKTWFIENALPHEKVECRILEDKRQYGHAIVKKWRVKSPER LEPKCAHFMRCGGCQGQHIPIEMQRKAKESALFKRLSKLQSEPISFQPMICGDAWAYRRRVRLSLWFNPSTKQIE MGFRQKNTNDLIPVQSCEVAEPAINYLLPKLTALLEKFSAPKQLGHIELVAADNGVAMLLRYTKNLAEIDRTLLL KFAEQEKLMLFLQSDKGIEQIYGDAPYYQFSDGIKLHFDIRDFIQVNSALNEPMVNTALDWLELSQQDCVLDLFC GMGNFTLPLAKRVKSAVGIEGVFEMVQKAAQNAERNQIKNIEFFQADLDQSFVEQPWANQSFNKILLDPPRSGAA FALNALCELKAEKILYVSCNPATLVRDAEILCNFGYKIEKSAVIDMFPHTGHLESITLFTTK Haemophilus influenzae NYSGXRC-6087f SGX Pharmaceuticals 2004-02-05 active Selected Cloned Expressed Soluble Purified EC2317 ICEDB: T1671 GENBANK NP_358526.1 MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMRVLKVNKKIGFGKVEKYLVQSPHRNQDLDLAYL RSGIADLGHLSYPEQLKFKTKQVKDSLYKIAGIADVEVAETLGMEHPVKYRNKAQVPVRRVNGVLETGFFRKNSH NLMPLEDFFIQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVRRGHYSGQIMVVLVTTRPKVFRVDQLI EQVIKQFPEIVSVMQNINDQNTNAIFGKEWRTLYGQDYITDQMLGNDFQIAGLAFYQVNTEMAEKLYQTAIDFAE LKKDDVVIDAYSGIGTIGLSVAKHVKEVYGVELIPEAVENSKKNAQLNNISNAHYVCDTAENAMKNWLKDGIQPT VILVDPPRKGLTESFIKASAQTGADRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVETVALLSKL DVDKHISVEIELDEMDLTSAESKATYAQIKEYVWNKFELKVSTLYIAQIKKKCGIELREHYNKSKKDKQIIPQCT PEKEEAIMDALRHFKMI Streptococcus pneumoniae NYSGXRC-6087g SGX Pharmaceuticals 2004-12-03 active Selected Cloned Expressed Soluble Purified EC2317 ICEDB: T2206 GENBANK NP_280151.1 MKKTLEEHAARFDDVAAAYDDDQTPEYNECVALVLEHADVGGADTVLDLGCGTGAIALGLAADAGRVVGRDISDGM LTQAREKATTRGVDNVAFDTGRFREPNYDGDADVVVSNFAMHHLSDAEKRSAIDTIAGLNPHRIVLGDVMLFGGP NPDAPFYSPAVDDPATVGVLADAFTDAGYAVTAVEMVHEQVGVLVAETR Halobacterium sp. NRC-1 NYSGXRC-6087h SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC2317 VFPLSIRILGGVAKGRELRVPESARPSGARIRKSLFDLLAARAPAGRFPHFVDLHGGSGAIGLEAASRGYRVTLIE KDSRAVGALERNARGLGLNARVFKGDALGQLPRAGQADIIFSDPPYQADIPAVARAVLSSGAVRPGGVVICQHPT QVTLPEHPGYLRDVRRQGSNVLTFYWRDAASGDEP Deinococcus radiodurans NYSGXRC-6088a SGX Pharmaceuticals 2005-05-06 active Selected Cloned Expressed Soluble Purified EC283 ICEDB: T676 GENBANK NP_418400.1 MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDS FPAASELINQLMTAMIAGVRNNPVLRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQEAEALRDALRAQNLNVH LIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSL ALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPP RSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK Escherichia coli NYSGXRC-6088b SGX Pharmaceuticals 2003-12-15 active Selected Cloned Expressed Soluble Purified EC283 ICEDB: T1746 GENBANK NP_439008.1 MQLPISQYNELLQKKLEKLTALLHPFNAPDIQVFDSPTSHYRMRAEFRIWHEQDDFYHIMFDQATLQRYRVDEFPI ASMLINRMMQTLLPLLKQQEVLHKKLFQIDYLSTLSNKIIVSLLYHKTLTEEWESAAKNLKDLLEKQDFDVQIIG RASKQKICFEQDYVDEVLPVNGRNYVYRQVENSFTQPNATVNCKMLEWAIDCTQNSEGDLLELYCGNGNFSIALA QNFRKVLATEIAKPSVAAAQFNIAENKVDNLQIIRMSAEEFTQAMNGVRAFNRLKGIDLKSYECNTIFVDPPRAG LDPDTVKLVQNYDRILYISCNPHTLCDNLVELSKTHRIEKAALFDQFPYTDHMESGLWLIRK Haemophilus influenzae NYSGXRC-6088c SGX Pharmaceuticals 2004-02-02 active Selected Cloned Expressed Soluble EC283 GENBANK NP_274683.1 MNDYTQQLQGKKDYLKTLFAGLDVPEWEVYESPDKHYRMRAEFRIWHEGGEMFYAMFEKGQKASGASMIRCDRFEA ASEAVNRLMPELIAAAAQSPELKKRWYAVEFLSTLSGEMLVTMIYHKRLDAEWMQAAQALQQQLDISVIGRSRGQ KIVLKQDYVTETLKVGNRDFRYRQIEGSFTQPNAAVCQKMLEWACRTAEGLGSDLLELYCGNGNFTLPLSRYFRQ VLATEISKTSVSAAQWNIEANRIGNIKIARLSAEEFTEAYTGKREFKRLKDGGIALTDYAFSTIFVDPPRAGIDE ETLKLVSQFDNIIYISCNPETLRANLDTLAETHAVERAALFDQFPFTHHIESGVLLKKKIL Neisseria meningitidis NYSGXRC-6089a SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble Purified EC2326 GENBANK NP_217205.1 VTRAGDDAVNLTLVTGAPANGGSCVAHHEGRVVFVRYALPGERVRARVTAQRGSYWHAEAFEVIDPSPDRIGSLCS IAGADGAGCCDLAFAAPEAARTLKAQVVANQLERLGRHSWQGEAQPLSDAGPTGWRIRVRLDVGADRRPGFHRYH SGELVTDLDCGQLPVGMLDGLVAADWPPEAQLYVALDDDGERHVVCSVRQGPRNRTRTVTNVVEGAYHAHQRVHR RSWRVPVTAFWQAHRDAAAVYSDLIADWAQPAPGMTAWDLYGGAGVFAAVLGEAVGESGRVLTVDTSRLASGAAR AALVDLPQVEVVTGSVRRVLAVQPAGADLAVLDPPRSGAGREVVDLLAGAGVPRLIHIGCEAASFARDIGLYRGH GYAVEKIKVFDAFPLTHYVECVALLTRKV Mycobacterium tuberculosis NYSGXRC-6089b SGX Pharmaceuticals 2003-11-05 active Selected EC2326 MTLPSLRLKANAERRLRAGHLWVYSNEVDVAATPLNAFAAGDQAVLEMANGKPLGIVALSPNNLICGRLISRDTKH VLDKSLLVHRINIALSLRERLFDKPFYRLVYGDSDLLPGLVVDRFGDVLVVQLASAAMELRKDEVLAALLQVLKP AAVLWKNDSSARDAEGLERYVANAYGEVPEWVALEENGVKFEAPVLAGQKTGWFYDHRMNRARLAPYVQGKRVLD LFSYIGGWGIQAAAFGASEVMCVDASAFALDGVERNAALNGVAEKVACVEGDVFEALRELKAADERFDVVIADPP AFIKRKKDLKNGEAAYRRLNEQAMRLLSKDGILVSASCSMHLPEDDLQNILIGSARHLDRNIQLLERGGQGPDHP VHLAIAETRYIKSLTCRLLPNG Pseudomonas aeruginosa NYSGXRC-6089c SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble Purified EC2326 ICEDB: T1672 GENBANK NP_465577.1 MRVIAGERKGHALKAVPGNNTRPTTDKVKESLFSIIGPFFDGDMVLDLFAGSGGLGIEALSRGAERAVFIDQAALA IKTIRQNLEGCHFTERAEVYRNDAERALKLLHKNEWKFDLIFLDPPYKKQQLEKLIGTLEKLELVNENGRIICEH DKEAIMPDTIGKFEKIKSVSYGITVLSIFEFQEA Listeria monocytogenes NYSGXRC-6090a SGX Pharmaceuticals 2004-03-31 active Selected EC2335 MLICPLCSAALGEVDNGVACPAGHRFDRARQGYLNLLPVQHKKSLDPGDNAAMVEARRQFLGAGHYAPLARRLAEL AAERAPRRWLDIGCGEGYYSARLGEALAGAEGYALDISREAVKRACRRAPQLSWLVASMARLPLADASCELIASV FSPIDWNEAVRILSPGGGVLRLGPASAHLLELRQRLYDDVRDYADDKHLAGLPAQLRLRHTETLEFRLALDSYDA RENLLAMTPHGWRVNPERRARILAEPFEVSVAVRYDWLQRD Pseudomonas aeruginosa NYSGXRC-6090b SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble EC2335 GENBANK ZP_01681855.1 LLIETTMTFLCPLCEHPLTLNQNTYACINRHQFDVAKEGYVNLMPVQHKRSKDPGDNKEMTQARRRFLHTGHYAPM REKVATLCQTYLTDRQQTLLDIGCGEGYYTDFFAKALRQQDSEAQIFGLDISKIAIRYAAKRYPECQFAVASSHR LPFANQSLDGVIRIYAPCKDTELERCIKIGGIVITVTPAARHLYQFKQGIYDQVRLHEEQPETLSGFELVEECKL HYPMALNGSEAADLLQMTPFAWRASEDFKHRVSQSDTFECEADFMLRVYRRK Vibrio cholerae NYSGXRC-6090c SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed Soluble Purified EC2335 ICEDB: T1673 GENBANK ZP_02285032.1 LLSKMEINKRALKENMALLACPICGAAFEFREPQSFVCLEGHGFDIAKPGYVHLLKQAHKTKYDQALFESRKKVIA SGFFEKLIERVTEIITEKKKEQLVLYDAGCGEGSHLARVVSNLQATGVNVKAVGLDIAKEGVKQAARDYPGTSWT VADLANCPNQAETADVILNILSPSNYVEFKRLLKKDGFLLKVVPEANYLRELREFIYVDEKSSYSNESVTSRLAE KLSVEHVERVTYKAPIAKELFADFLEMTPLGWHIEADKKNELLENPPEELTVDLQIIIANRAHLL Listeria monocytogenes NYSGXRC-6090d SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC2335 MDTTPDNSEKKKTSSVREATFSINESFGGRLLTEEEDVFEQNAWDHVEWDDEHLALAKKCIEEQKLYPVTEKDAYM THPERYWDQFYGKNEGKFFMNRRWIAQEFPELLDLLKEDAGEKSILEIGCGAGNTIWPILKENKNSNLKIFAVDY SEKAIDVVKQNPLYDAKFCSASVWDLAGSDLLRSIEEASIDAITLIFCFSALSPDQWQQAIENLYRLLKPGGLIL FRDYGRLDLTQLRAKKNRILSENFYIRGDGTRVLIVNRKKRVKMYRCWLQAKFQK Schizosaccharomyces pombe NYSGXRC-6090e SGX Pharmaceuticals 2004-03-31 active Selected EC2335 MMTNDFLKNKKFIFDRWANSYDWLFPSIFYQAIHKRLLEFVDLSQPANILDLGCGTGRLLERLANKFPELRGTGLD LSSNMLRQARLSNRHHPRLIFLEGKAESLPFGDGQFDAVFNTISFLHYREPEKVLQEVSRVLSPGGRFYLVDFTT TREKLPEILPISSQGIRFYSPHQREVLGSSTGLLCVNHHYLLGPVLLTIFAKPS Nostoc sp. NYSGXRC-6090f SGX Pharmaceuticals 2004-02-17 active Selected Cloned EC2335 GENBANK NP_281009.1 MPSGGVLPVGVHATPMSVREEFDEWAASGRDKGMEDRHWHTAKDVLARMPVEDDDTVLDLGTGSGYAVRALRERGV ARGYGLDGAPEMAANARTYTDDDDLAYVVGDFGSLPFADDAIDHVFSFEAFYYASDPRETLAEIRRVLKSGGTFY CGVNYYEENVHSHDWQDSISVEMTRWDRATYREAFRGAGLHVAAQDLIADTEIDIPAASEFPHEGFDSRADMVER YRTFGTLLTVGVAP Halobacterium sp. NRC-1 NYSGXRC-6090g SGX Pharmaceuticals 2004-03-31 active Selected EC2335 MAEAGGEPVQQERDGHGKKPHRNRSARAAPSDSAPKWPAGILSGRSTLPRVSCPMSDPVLARPAALRRAFDRRAAR FAEADFLLREVGQRMQDRLSYIKLTPARALDLGCGLGQGLAVLRAQYPDAQICGLDWSAAMLARARQLDPQHSDG GWLGRLLKKRPVFDFAQADFRALPFADASFDLLWSNLALHWDPSPHAIFPEWHRVTAEGGLLMFSLFGPDTLREL RSALAGIDASVHTLRFVDMHDIGDMLVHGRWSTPVMDMEQITITYESPQALLADVHLLGGMAGLADGDGRALSGP GLYTPRWRQHLFDALDAQRNPDGLIPLTFEVVYGHAWKLAPNPRQALDEQGRAMIPVDRIGRRPRA Ralstonia solanacearum NYSGXRC-6090h SGX Pharmaceuticals 2004-02-18 active Selected Cloned Expressed Soluble Purified EC2335 ICEDB: T1677 GENBANK NP_294145.1 MTWNPDQYHQFKDARSAPARDLQALIPERPYAQVVDLGCGTGEQTAQLAQRFPQATVLGLDSSAAMLAKAGAQQLP NLRFEQGDIQELSGSFDLLYSNAALQWLPDHPRLLARLWEHLRPGGVLAVQVPANHDHASHRLLTATANEFETEL GGFTRFGTAHGASPVLTPAAYAELLDGLGAVDITALSKVYPVVLPGAEGLIEWTKGTALVPYLSRLDGADAARFL DVYRGKLQAEFPGERVYYAFTRVLFVATRPEL Deinococcus radiodurans NYSGXRC-6090i SGX Pharmaceuticals 2004-03-31 active Selected Cloned EC2335 GENBANK NP_460791.1 MSFTCPLCHQPLTQINNSVICPQRHQFDVAKEGYINLLPVQHKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAVIN LLRERLDQSATAILDIGCGEGYYTHAFAEALPGVTTFGLDVAKTAIKAAAKRYSQVKFCVASSHRLPFADASMDA VIRIYAPCKAQELARVVKPGGWVVTATPGPHHLMELKGLIYDEVRLHAPYTEQLDGFTLQQSTRLAYHMQLTAEA AVALLQMTPFAWRARPDVWEQLAASAGLSCQTDFNLHLWQRNR Salmonella typhimurium NYSGXRC-6090j SGX Pharmaceuticals 2004-01-07 active Selected Cloned Expressed Soluble Purified EC2335 ICEDB: T1751 GENBANK NP_359504.1 MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDLAKFGYVNLAPQIKQSANYDKENFQNRQQILEA GFYQAILDAVSDLLASSKTTTTILDIGCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDL ARLPIKDASMDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIKEHFQEHFT ILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEILVGKAF Streptococcus pneumoniae NYSGXRC-6090k SGX Pharmaceuticals 2003-12-02 active Selected EC2335 MNGLFDTSHIRRAFSRAARSYDTNAILQHEVEQRLLESLDYLGDRIPRVILDVGAGTGRASIAMKKRWPKAQVIAF DQAMPMLQEARKRSHWWKPLAQICGDARTLPVADASVDVIFSNLCLQWIEDLPTVFAGFRQALRPGGLLLCSLFG PDTLIELREAFAQADAVPHISPFPSMPQCGDALVLAHFQNPVLDRDLFTLTYDNLSALMRSLRAIGATNALQERR TTLTGRGRFAATATAYETLRNADNKLPSSWEVIYACAWAPTSDPMTRENNHEIASIPINSIPIRRRNSS Xylella fastidiosa NYSGXRC-6090l SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed Soluble Purified EC2335 ICEDB: T1760 GENBANK NP_243397.1 MRKMTGEEFDPLVSFFDGMAQASWLRPVHDRLKKGTGSWANRAVLDVGCGTGRLLARGVHEAAHLAGVDLSKQMVL ATEERLHEHKQCGRLTVVQGDAYDLPFADESFDVCLSTCVMFLLPEPERGMKEMIRVLNGAGVIGMLNPTNKMNH AAAKAYCKKSGITGFEEKTLLQWSNVSTRRHRYTAEQLTHFFKQHGAWVVTHELVLDGLAVVTVASWNK Bacillus halodurans NYSGXRC-6091a SGX Pharmaceuticals 2004-02-18 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1678 GENBANK NP_416336.1 MSFSCPLCHQPLSREKNSYICPQRHQFDMAKEGYVNLLPVQHKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIVA QLRERLDDKATAVLDIGCGEGYYTHAFADALPEITTFGLDVSKVAIKAAAKRYPQVTFCVASSHRLPFSDTSMDA IIRIYAPCKAEELARVVKPGGWVITATPGPRHLMELKGLIYNEVHLHAPHAEQLEGFTLQQSAELCYPMRLRGDE AVALLQMTPFAWRAKPEVWQTLAAKEVFDCQTDFNIHLWQRSY Escherichia coli NYSGXRC-6091b SGX Pharmaceuticals 2004-01-12 active Selected Cloned Expressed Soluble EC286 GENBANK NP_244777.1 MFIDKQTVERHFSKSAHLYDGVNHVQRKMAHRLVQLLDEKRRDAKDEPRAILDIGCGTGWLTRECLKSFPQATIDA VDLSKQMLEVAEKNVSSHPNVQFIQGDIEKMVREKPSAKTYDVIVANAVFQWLDKPTETVAQLRSWLKPNGLLLF STFGPDTFYELHDSFQLAAKQLGIIDERRGLDYLSKTEWKRTLDGLFAELTIHEEKAIESYATVEQFLHTVKKMG ATYSQSSRPLSKRYYQLMKEIYEQRYRTEDSIPATYDCLYVLCQA Bacillus halodurans NYSGXRC-6091c SGX Pharmaceuticals 2004-02-05 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1762 GENBANK NP_393670.1 MISNHFLRDLYAIIVDDVGRFKPSAILDVGCGTGTADYFILSAFPDISVDCIDPSPYMISIARKKLSKFGSRVRAE LGSSRSIPFDRRYDFVFTSISFHHWKCREDGLRNMAKYVSDHGVLAVYEYYRPNLRSFHRVAGKHALTMEDVEKL NIEGFTKKYEIRGEMMRIMFQRD Thermoplasma acidophilum NYSGXRC-6091d SGX Pharmaceuticals 2005-02-23 active Selected Cloned Expressed Soluble Purified EC286 GENBANK NP_142222.1 MGFKEYYRVFPTYTDINSQEYRSRIETLEPLLMKYMKKRGKVLDLACGVGGFSFLLEDYGFEVVGVDISEDMIRKA REYAKSRESNVEFIVGDARKLSFEDKTFDYVIFIDSIVHFEPLELNQVFKEVRRVLKPSGKFIMYFTDLRELLPR LKESLVVGQKYWISKVIPDQEERTVVIEFKSEQDSFRVRFNVWGKTGVELLAKLYFTKEAEEKVGNYSYLTVYNP K Pyrococcus horikoshii NYSGXRC-6091e SGX Pharmaceuticals 2003-12-18 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1743 GENBANK NP_347206.1 MSELARRLNQCKKPVGDQGKVVVDDMNERHYELTGWGLDKIKIDKAYKMLDIGCGGGRTVNRLSKAAEEGEVYGID YSSDCVRWASEYNKELIKEGRVHISEASVEKLPFEDNKFDVVTAVETIYFWPNVEENIKEVNRVLKKGGKFIIIN EIYDDDKFRERNNEFAKNSNMKIYSPEKLKSLLKNAGYLNVEMEIKEENNWICYVSEK Clostridium acetobutylicum NYSGXRC-6091f SGX Pharmaceuticals 2004-06-08 active Selected EC286 MSKPTDQLYYANGVDSYIAETHAWRTPETCSTYMLKYVKKTDRILDVGCGPGTITVGFPKYVPEGEVIGVEPSQEL LDKAEEALRKEETLKKEKINNCSFRLGSIYKLPFPDNTFDIVNTHQVLVHLQDPVAALVELKRVTKPGGYVCCKE ADLLSACVYPKEYEHDLLLQSQARINLHGTNPTAGRSLRGWAIDAKYVAENIHSSASTWCFADEETRKWVSRLFI QRVLHSNERLDDDDAKDQSLRKRVAEAWQRWKEDSRGCFFMTDGQIVYKKEE Schizosaccharomyces pombe NYSGXRC-6091g SGX Pharmaceuticals 2003-12-22 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1742 GENBANK NP_464164.1 MKHHHNHHGEAGFKRKVDYLDRPERSEVLSPEDFLQAMPIGKTASILDLGAGTGFLTIPAAKLVDNTVFALDLDAK MLELIESKAKEAGLANVETLEASMDDIPLEANSVDVVLASLVLHEADSLADVLREVSRVVKTGGYFASLEFDTKG TDLKGPPMEIQISAEKLKEELAGFGFEVVKNWQLDEGMYVSIAVKK Listeria monocytogenes NYSGXRC-6091h SGX Pharmaceuticals 2004-01-29 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1755 GENBANK NP_214465.1 MKNTLGRQFSRATETYEKWAVPQRKSAKILVEFVKPSGLVLDLGCGTGFVSEFVNDCEVVGLDISEGMAKAYREKF RKVVIGNAENLPFKDRSFDFVLSNFSLHWSDWRKSIREALRVCKNFVGVAIPVYGSVSFSEFPFPKAEEILEEFK PQEFKIINLEIPFRGMELIKFFHYTGTANFTGKKNFKTKRELIKLSKDLEKEYFKVLFLKLKSRAF Aquifex aeolicus NYSGXRC-6091i SGX Pharmaceuticals 2004-06-08 active Selected Cloned EC286 MLDYYAKRAPEYERIYAKPERQADLAWLRARVREFTRGAQVLDLACGTGYWTAAMAQARSIVGADVNDTVVRIARA KGIAGASFVLADNDALPFAPGRFDAMTAGGWWSHVPRQGLRAHLGRLHGVLGPGVRVLWFDNRYVPGSSTPIAYA DDHGNTWQRRPLDDGSLHDVLKNFPDDRALLEAVDGIATDVRITRLQYYWTLEYLTH Ralstonia solanacearum NYSGXRC-6091j SGX Pharmaceuticals 2004-01-27 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1753 GENBANK NP_816303.1 MLKKIERAQQLLKKEAAVFRCPTCHEPMHLEGVGLICQQRHQFDLSKKGTLYFLNHGVQTEYNKKMFTSRGKMIQS GMYAPVLNKIMHYLPQNKTVVDVGCGEGSFLAELSQAGLSGLKIGFDLSKEGIYLASNQPIDAFWCVADLTNLPF ANEGLDTILNIFSPSHYQEFRRVLKADGTVIKIIPEENYLKELRAAFYPNDEKKQSYSNQKVVQRFAEELAVEVD ERITYCFDIPEERRLDLLEMSPLEWQVSQEVKAELQQRPLEKITIDVRLLVGRKR Enterococcus faecalis NYSGXRC-6091k SGX Pharmaceuticals 2004-02-16 active Selected EC286 MDQSTRARTRTAFAIDAVGQGAKAAVKAVWWTATGGLARSLTRPTEGPQARRFTPAAPPPVPGSLRRAYLEAFEKD ARDVAAGLYPAIEDGPIRPSAALREAVDFLVDAFEVDQRRRRGDGAEVRNAADPSVYPNYYRQNFHYQSGGWFTA ESAGRYDAQVEALFSGTAGAMRRRGLSLLARHWRGRDHRDAKILDVACGSGAFLKDLSAAFPRAALAGLDLSEAY LAKARKRTAVGGVKAKAETLPFGDATLDAVTCVYLFHELPPRVRPVVAASLARVLKPGGVLVLVDSVQPVDTPDL ARLLEAFPVYFHEPYYSSYAETNLEALFAEAGLRLLDQDCAFLTKAMLFVKPGG Caulobacter crescentus NYSGXRC-6091l SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed Soluble Purified EC286 ICEDB: T1858 GENBANK NP_391780.1 MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYVNFLTKPVKTSYGAELFEARSRLIGECGFFDPL HDAIAELISHPKSGHEAFTILDSGCGEGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVAR APFHDRQFDVVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVERFTANAAHS RPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVDILIGMK Bacillus subtilis NYSGXRC-6092a SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC3518 GENBANK NP_391305.1 LILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVRPGLHGKPFTLYKFRTMTDERDSKGNLLPDEVR LTKTGRLIRKLSIDELPQLLNVLKGDLSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKF ELDVWYVDNWSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS Bacillus subtilis NYSGXRC-6092b SGX Pharmaceuticals 2004-03-31 active Selected EC3518 MLKRIFDIVVASLVLVLLAPVLVVVYWRVRTRLGSPALFTQLRPGRAGRPFRMIKFRTMTDARAADGTLLSDAERL TPLGQMLRASSLDELPELWNVIRGDMSLVGPRPLLMDYLPLYTPSQARRHEVRPGITGWAQVNGRNALSWEQKFA LDVWYVDHRSFWLDLRILGMTVRKVLRRDGISAAGEATMTKFTGSDEVQRRG Ralstonia solanacearum NYSGXRC-6092c SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC3518 MSKFFKRLFDIVASASGLIFLSPVFLILIYLIRKNLGSPVFFFQERPGKDGKPFKMVKFRSMRDALDSDGIPLPDG ERLTPFGKKLRAASLDELPELWNILKGEMSLVGPRPLLMQYLPLYDNFQNRRHEMKPGITGWAQVNGRNALSWDE KFACDVWYIDHFSLCLDIKILLLTVKKVLIKEGISAQGEATMPPFTGKRKLAVVGAGGHGKVVADLAAALGRYRE IVFLDDRAQGSVNGFSVIGTTLLLENSLSPEQYDVAVAVGNNRIRRQIAEKAAALGFALPVLVHPDATVSPSATV GQGSVVMAKAVVQAGSVLKDGVIVNTAATVDHDCLLNAFVHISPGAHLSGNTHIGEESWIGTGACSRQQIRIGSR ATIGAGAVVVRDVSDGMTVAGNPAKPLPRKNPETSTA Neisseria meningitidis NYSGXRC-6092d SGX Pharmaceuticals 2004-01-12 active Selected Cloned Expressed Soluble EC3518 GENBANK NP_244583.1 MYLRLKRLIDLVLSFIGMIVLSPIFLLLIIGIKLDSKGPVLFKQKRVGINKTHFHILKFRTMRIDTPKDTPTHLLK NPDQYITKMGKFLRKTSLDELPQIWNIFVGHMSIIGPRPALWNQYDLIVERDKYGANDVPPGLTGWAQINGRDEL PIEVKAKLDGEYVQNIGFWMDVKCFVGTIWSVLRSDGVVEGGTGSAKKEIASTKRR Bacillus halodurans NYSGXRC-6092e SGX Pharmaceuticals 2004-02-16 active Selected Cloned Expressed EC3518 GENBANK NP_282272.1 MYEKVFKRIFDFILALVLLVLFSPVILITALLLKITQGSVIFTQNRPGLDEKIFKIYKFKTMSDERDEKGELLSDE LRLKAFGKIVRSLSLDELLQLFNVLKGDMSFVGPRPLLVEYLPLYNKEQKLRHKVRPGITGWAQVNGRNAISWQK KFELDVYYVKNISFLLDLKIMFLTALKVLKRSGVSKEGHVTTEKFNGKN Campylobacter jejuni NYSGXRC-6092f SGX Pharmaceuticals 2004-03-31 active Selected Cloned Expressed EC3518 MLTNSIIKTKENSMLKWEDLPVEMKSSEVESYYQLVSKRKGSLIFKRCLDWVLALVLLVLTSPIFLILSIWIKLDS KGPVIYKQERVTQYNRRFKIWKFRTMVTDADKKGSLVTSANDSRITKVGNFIRRVRLDELPQLVNVLKGEMSFVG TRPEVPRYTEQYSPEMMATLLLQAGITSPASINYKDEDTIISQMTEKGLSVDQAYVEHVLPEKMRYNLAYLREFS FFGDIKIMFQTVFEVLK Streptococcus pneumoniae NYSGXRC-6092g SGX Pharmaceuticals 2004-11-17 active Selected Cloned Expressed Soluble EC3518 MTAQSSLLSGKRRLRQDASSSMRSTVKRGQKTKTPKIKPKGLSLQGINGEFAKRLFDIVFSLLVLILFSPVYLILA SLIALSSEGPIFYVQERIGQNYKPFNCIKFRTMVSNADEVLMQMMETSPQLRQEFESSFKLKKDPRITKIGQFLR ITSLDEFPQFWNVLKGDMSVVGPRPLVAEELPKYGDHIEQVLTIRPGITGLWQVSGRNDIPYPRRVQIDLHYVKS RTLWLDLWIILKTIDVVIMPKNNGAY Nostoc sp. NYSGXRC-6092h SGX Pharmaceuticals 2004-02-02 active Selected Cloned Expressed Soluble EC3518 GENBANK NP_357280.2 LLLFYATVNIAQALIGRSRKKSHRRSWAMCLTKNPLASNSEHRLVISFRRKDTPPGTDQSQNINGVLSMKSATQSA EQTLSSSEDFDVSFPIGGIAKRSFDMTSAALALLIFSPIFLLIAVLVKLSDPGPIFYGHRRVGHNGRYFHCLKFR TMAMNGDEMLRQYLAANPEAAEEWRATRKLKNDPRVTAVGAVLRKLSLDELPQLLNIIRGEMSVVGPRPVVDEEL SYYENAAAYYLSTRPGLTGLWQISGRNDVSYKTRVAFDTQYVQNWSMRQDVFIIVKTIPAVCMSRGSY Agrobacterium tumefaciens NYSGXRC-6093a SGX Pharmaceuticals 2003-11-05 active Selected EC3524 LKKLQLKKWKCRENDIEAVHNNKGYAYQRKLDALEEVRKGYYPIKRAIDLVLSIVLLFLTFPIMFIFAIAIVIDSP GNPIYSQVRVGKMGKLIKIYKLRSMCKNAEKNGAQWADKDDDRITNVGKFIRKTRIDELPQLINVVKGEMSFIGP RPERPEFVELFSSEVIGFEQRCLVTPGLTGLAQIQGGYDLTPQQKLKYDMKYIHKGSLMMELYISIRTLMVVITG EGSR Staphylococcus aureus NYSGXRC-6093b SGX Pharmaceuticals 2004-02-16 active Selected Cloned EC3524 GENBANK NP_349673.1 LQNLELEDKKVVFMPEESLDKGIGYFIIKRIIDVFGSLVGIIFLSPVMLIVIVAIKLDSKGPIIFSQKRVGQNGRI FNMYKFRSMVENAERLLGKLQDKNEMSGPMFKMSDDPRITKVGRFIRKTSLDELPQLFNVLRGHMSLVGPRPNLP NEVKEFNEFQKRKFMVKPGLTCYWQVMGRSSIGFEEWIELDLKYIKERSTFVDLKLIFRTFFLLFGDKNAM Clostridium acetobutylicum NYSGXRC-6093c SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC3524 MWSHRHLPSSVLRRCFLLVAILIKLEDPKGSIIYKQERLGKDNKPFMIYKFRSMVEGAEKKTGPVLATQNDDRITK VGKFIRATRLDELPQLFNVLKGDMSLVGPRPERSFFIEQLSKEHLDYAYRNTVQPGITGYAQIMGKYSTEAEDKL RFDLYYIRNYTFWLDIVIMLKTFTVLLDKTKAEGTDSKKKWKRASKNKDGNVTA Bacillus halodurans NYSGXRC-6094a SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC3868 GENBANK NP_229565.1 MKDYTYSVTEINEYIKDLIEGDPYLTNVSVYGEISGVRPRKGHIFFSLVEENARLECVIFGGDNMGIRLQEGRMAL VEGSVSVYIPHGTYRFICSNVRYLDQAGMYQIKFETTLKKLLEEGLLSRPKKTVPRFPRKIGIITSRDSAALQDV IRTARERKAPIEIYVFHTSVQGDSAREELIKALRKANEYDLDLVMIVRGGGSKEDLWVFNEEDVIREILRLRHPV VTGIGHEIDRVIADFVADVSMHTPTGAAEYVIPDASEIHEDLDSFFEKLITSLSNRFDMEERRLETLYFRLRMIG RRKLELNEFKIERVKELAAKLRKKLMDYFEHNQKKLDSLGRMLESLNPLRPLERGFVLVKKDEKIVKESTDLKRG DVVSLVFKDGTKKAQVIG Thermotoga maritima NYSGXRC-6094b SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3868 MSDLPPTDSNAPPYSVSELAFALKRTLEDRYGFVRLRGELSKVTHHSNGHVYLTIKDDKSAIDGVVWKGNVRGLGV RPEHGLEVIVTGKITTYPAGSRYQIVIDSMEAAGVGALLAQLERLKAKLAAEGLFAPERKRPLPSMPAVVGVITS PTGAVIRDILHRIRDRWPCQVLVWPCVVQGDAAAGQVSAAIRGFNAIQPGGPVPRPDVLIVARGGGSVEDLWAFN DEGLARTVAEGTIPLISAVGHETDTTLIDFVSDRRAPTPTAAAEMATPVLAELRALISDLDRRLNRCGARTIEER RTRLVSAARGLPRPNDLLALAQQRFDIASGRLDAALDRNTTVHAQSLLKVTARLTPEALGRQRAVKAERLADLSR RLDLAARRAPDRVAQHARLPALWDRLNAAGQRRLQRDADRLENLEKLRQSLNPERPLELGFALVRKGDGTLARSA ADLVSGERVNLKFKSGDRDAVIDGEGGPAPAPTAPAPKPRPKPAAPPAGQGDLF Caulobacter crescentus NYSGXRC-6094c SGX Pharmaceuticals 2004-03-31 active Selected EC3868 VLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQYADFTPREGEAIEVRA LVTLYEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFDAARKRPLPRHPHAIGVVTSLQAAALRDVLTT LHRRAPHVPVVVYPVPVQGAGAAERIAAMLDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVA GVGHETDVTIVDFVADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQAQ MRERRAGLAHLEGRLRFALHGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALARAMRATLDRAQTRLSH HQAGLELLAPQRTLERGYAVLLDAKGQAIRDPAALHARARIEARLARGAVDIEIAQVQPKLPEM Ralstonia solanacearum NYSGXRC-6094d SGX Pharmaceuticals 2004-03-31 active Selected Cloned Expressed EC3868 GENBANK NP_358682.1 VEMEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWSGIYQKLGFDLEEGM KINVIGRVQVYEPSGSYSIIIEKVEPDGVGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVI RDIITTVSRRFPGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFES RLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQS VIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMAL VYDAKVAEAKRLSEALLMLDTSRIVARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI Streptococcus pneumoniae NYSGXRC-6094e SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC3868 MKPTPYHINQPAIPVGTEMSSLSKREIEKILRTLERDREFRYALMGLLGFKELLERFEKLEERQLRLEERFSQLEE RQIKLEERFQLLEKRFQRLEERHLRLERRFQKLDERFQRLEQRQLRLEERFQRLEQRFQSLEERYLRLEQRFQRL EERFRLLEERFQKLEQRQLHLEERFQRLEERQLKLEQRFQKLEERHLKLEQRFQRLEEEFRRLSERVLRVEQALV NMMRMMNTIAHRFGILTEEAFRSAMKHVVEEVLGAGVVGRWIHHDKEGIVYGHPSIVEVDVVVKDGQHVLVEIKS QVTQADVAEMHRIGLLYERAEGVKPRLVIVGGFVDERARALAERLGVEIAPITPQ Aeropyrum pernix NYSGXRC-6094f SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed EC3868 MSDFFHSDVLSVSELNAFAKSLLENHLAGLWIAGEVSNLTRAASGHYYFSLKDSRAQVRCAMFKGAAVRLAKPLKE GDHIEVSGKISIYEARGEFQITVNEVRLKGLGQLYEAYERLKAQLQAEGAFAAERKKPLPVRPQCIGIVTSLAAA ALRDVVTTLKRRAPEIPVIVYPTPVQGAGSELQIAQAIKTASQRAECDVLIVCRGGGSIEDLWAFNEEPVVRAIE SCTVPVVSGVGHETDFTLADFVADMRAPTPTGAAELVSPNRQESLHRLAQAQCRLKTVLEQRYFDASQKLDWLAR QIRHPRQKLDEQRASIGKLAQTLSYSMTQNVRTHTARFERQTQALKHCRPDVSVCKKNIDRFQTALSHAFHQLLT HRRQSLTAQAALLEAVSPQHILERGFSVVKNTRGQVIRNADVLKQGQKLHIIFADGETDVRVSKEQGQQDLFDCI Neisseria meningitidis NYSGXRC-6094g SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed Soluble Purified EC3868 ICEDB: T1757 GENBANK NP_213998.1 LMKFLLILIFLASFSFSLTPEEEKQLLKDIAEIKTTLKAFIREADERFEQVDKRFEDVNRRFEDFNRRLNDLREDM NKRFELVDKRFIELREDMNKRFELVDQRFEQLYTFLWIITGIFTTLTASVIAFAWWDRRTIIRKTKEETFEEMEK ELKPEKFRKIMNALREKAKTDKELEAILKKYGLL Aquifex aeolicus NYSGXRC-6094h SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble EC3868 GENBANK NP_464886.1 MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSVMFHKAVQKIGFVPEDG MNVLVTGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKAQLEKEGLFAETHKKVLPSFPSKVAVVTSKTGAA VRDILTTIHRRMPSVEVIVYPTIVQGEKAAQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYD SDVPVISAVGHETDFALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQH LILNGPKHQLEQQMERTDYFSERLNNAFSKQIFVKQTAFDRLNDRLHYYHPNKEIELQKEQMTLHLQALDKAMKQ LLKDKQQSFFRQVDALEHLSPLSLLKRGFGVTYKENTLVKSVQELEVGDNIQVKMQGGHIDALITAKEEDISGN Listeria monocytogenes NYSGXRC-6094i SGX Pharmaceuticals 2004-12-03 active Selected Cloned Expressed Soluble EC3868 GENBANK NP_348701.1 MYIKVLSVSELNNYIKRVVDSDYILSNAQVKGEISNFKFHSSGHVYFSLKDEGGKINCIMFRSNAEKLKFIPENGM KVNVKGRVSVYVKDGAYQLYCTEITPEGRGELYEAFEKLKEKLLNEGMFSEEHKRNIPKYPKMIGVITSPTGAAI RDIINVATRRNKSVDMIICPTLVQGVNAPGELIKALDYLNNREDIDTIILARGGGSIEELWAFNDEKLAYAVYNS KKPVVTGVGHETDFTIVDFVSDRRAPTPSAAAEIAVPNINEEMNSFVSLKRALDTSIKTYIQNKCNQLEIAKRML EKNSPEILIVNGYSSIDNFKYVLDMRIANKIKIEKEKILRYNSILKSNSPINILNKGYSIISDEIGNNISNVDKL KEPDKVHITFKDGKVNAKIDILR Clostridium acetobutylicum NYSGXRC-6095a SGX Pharmaceuticals 2003-11-05 active Selected EC3862 MSDYLSVSALTKYIKYKFDQDPHLQSVLIKGELSNFKKHSSGHLYFNVKDKESVISAMMFKGSASKLNFEPKEGDE VLLEARVSVFERRGNYQIYVNKMQLDGIGNLYQKLEALKKKLTEEGCFDKANKKSIPKFPKKIAVLTASTGAAIR DIHSTINSRFPLAEQIQISTLVQGEKAKDDIIEKIEYADSLGVDTIIVGRGGGSIEDLWNFNEEAVVRAIYNCKT PIISAVGHETDFTLSDFAADIRAATPTQAAVIATPDQYELLQQIQQYQFTLTRFIKKHLEQQRKHVEHLSSYYKF KQPTLLYDQQIQRRDDLEKRLKQQIQATFEQQRHRLMLLQQRYNLKALLSSVNQEQQNNLQLTNQLVKLLNSKIL SYKNDLKNKVENLNNLSPTNTMLRGYAIVNKKDEVITSTKDLTENDQLTLTMKDGLVDAKVTKVRCNND Staphylococcus aureus NYSGXRC-6095b SGX Pharmaceuticals 2004-02-16 active Selected Cloned Expressed EC3862 GENBANK NP_353300.2 MVSSTLKSVSRCRHFRIDGFWLQTVMSDIFSHTALSNLAEFSVSELSGSIKRTVETAFEQVRVRGEISGYRGPHSS GHAYFSLKDDRARIDAVIWKGTFSRLKFRPEEGMEVIATGKITTFPGSSKYQIVIESLEPAGAGALMALLEDRRR RLAAEGLFDSARKRPLPFMPRVIGVVTSPTGAVIRDILHRISDRFPVHVVVWPVKVQGEGSGEEVANAIRGFNAL KPGGDIARPDVLIVARGGGSLEDLWSFNDEIVVRAAAESEIPLISAVGHETDTTLIDYAADVRAPTPTGAAEMAV PVRAELEAQLSGLAARLSGSVSRQMDNRRQGVRALVRALPSLDQLLALPRRRFDEAASGLGRGLELTTLNKRRAF ERSASGLRPETLLNGLKHHRQRITERMHRAETLVERRLLQGKGRVDSFDSALRSLPARLLGQLERQKERVVTAAR RADTAVLHRMAQNRSGLAAHDRILQSLSYKNVLNRGYAVIRDEENRPLTRAAAIASGAAVSMEFADGRVSAITTG EGTPAPETAAAPKKKPAKPASSDPGNQGNLF Agrobacterium tumefaciens NYSGXRC-6095c SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3862 MSDYLSVSSLTKYLKLKFDRDPYLERVYLTGQVSNFRRRPNHQYFSLKDEKAVIQATMWSGIYRKLGFELEEGMKI NVIGRVQLYEPSGSYSIIIEKAEPDGIGALAVQFEQLKKKLAEAGYFDDRHKQRLSQFVKKIGVVTSPSGAVIRD IITTVSRRFPGVDILLFPTKVQGEGAAQEVADNIRLANERTDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESHL PIISSVGHETDTTLADFAADRRAATPTAAAELATPVTKADLLAFLKERQMRSYQAVMRLIRQKDEQVKKLQRSVI FRQPERLYDAYVQKLDHLRTHLLTKVRQVYDVYDSKEHLLRQRLLSFNLSGCIQRYQAQLKQDQRLLLSHMSSQY DSKLARFEKAQDALLSLDTTRIVARGYAIVQKDNHIIQSTQQIKKGDRLHLEMKDGQVQVEVENVKQEENI Streptococcus mutans NYSGXRC-6096a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC3864 GENBANK NP_207057.1 VDVLSVSEINAQIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIKCVLFKGNANRLKFALKEGQEVV VFGGISVYVPRGDYQINCFEIEPKDIGSLTLALEQLKEKLRLKGYFDEENKLPKPHFPKRVAVITSQNSAAWADM KKIASKRWPMCELVCINTLMQGEGCVQSVVESIVYADSFHDTKNAFDAIVVARGGGSMEDLYSFNDEKIADALYL AKTFSMSAIGHESDFLLSDLVADLRASTPSNAMEILLPSSDEWLQRLDGFNVKLHRSFKTLLHQKKAHLEHLVAS LKRLSFENKHHLNALKLEKLKIALENKTLEFLRFKKTLLEKISTQTLTSPFLQTKTERLNRLENALKLAHANLKL PQFGALVSKNNQAIELEALKRGDKIELSNEKTRASAEILSVDRV Helicobacter pylori NYSGXRC-6096b SGX Pharmaceuticals 2004-01-29 active Selected Cloned Expressed Soluble EC3864 GENBANK NP_293910.1 VTEPDSKPKKGRAGRKKAEPVRPPEQFLELAELLDYVGQVIARGVPGGVWVRAEIASLTDRRHLYLDLVQAGEGGA GGVGEVAKCRATVWARERFALEAKFRGATSGATLSAGLKVLLFGTAEFHPQYGFSFNVLDISPEYTLGDAALRLE AMRAELVAEGSYGLNRLLPVPTDFARVAVIAPREAAGLGDFRREADPLEAAGLVEFHYLEATFQGREAGASLLRA VAAARELHQEKALDALFVIRGGGAVTDLAWLNDLELARALATFPAPVVTGLGHARDDTLPDEVACLRTDTPSKAA AYLVRTVVNAAAQAQEAARTIRAEAARVLVEAEAAAAWARDRALSSAVRRVDAAAAEVDALMRQALGLTPQRTLA RGYALVRDAAGQPVTRAAGARAGEPLTLEWSDGSVPVRVE Deinococcus radiodurans NYSGXRC-6096c SGX Pharmaceuticals 2004-02-16 active Selected Cloned Expressed EC3864 GENBANK NP_281516.1 MTPTELNLKAKALLETHFDDIVLSGEISKITLHGSGHWYFDLKDERSSIACAMFKGANLKVGFKPAVGDFLELCGS VSLYPESGRYQFIATSMKKAGFGDLEAQFLALKERLQKEGLFDPRFKKSLPKFPKKVGIITSKTSAALQDMLKLI HQKEYFLAKIYIFDALTQGNNAPFSLIQALKKADDMDLDVLIIARGGGSREDLFCFNDENLAREIFKAKTPIISA IGHEIDYVISDFVADFRAPTPSAAIDTLFYSKLDIEQSLDLMEEKLMQLWNYKIQNYENLLLNLSKFFKFNSLPK IIDEKIKQSHNIEKQLNHLLANQMRYNELKLDKLQNAYLQHENFFNKSKKFICIRKNGKIANLEDLKSDDIVILS SQTSQKEAKIL Campylobacter jejuni NYSGXRC-6096d SGX Pharmaceuticals 2004-01-22 active Selected Cloned Expressed EC3864 GENBANK NP_230415.1 LSSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVKCAMFKGNNRLVNFKPQ NGQQVLVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKMQLAAEGLFAQTRKKPLPENPRCVGIITSRTG AALHDILHVLKRRDPNLPVVIYPTLVQGEEAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTI AASEIPIISAVGHEIDVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARLQ HKLDKQHPQARLERQQQQLDELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQQRFNLIQQEQRINQSI QRYLIQSRHQLALLSEKLDAVSPLATLARGYSVTRTTQGELVRQSAQVKPGDTLVTQLMDGEILSTVNSR Vibrio cholerae NYSGXRC-6096e SGX Pharmaceuticals 2004-02-06 active Selected Cloned Expressed EC3864 GENBANK NP_110162.1 MEFLEQEGQEVLTKEIKAGFCEITPSSITEQTTKPQLDETQLVDEYVHTKELETTPIPISFATKEVLFEEVFNTPS TQQVDESVLVNEYIELTQQIKNASEQVSSNHTHKFSVATEPAATKAVSETMLLDDYVEMVEQDVQAQTALPQAAL DPTVSLTFSSPIDSNAILVYPEMKVPHVFDTVAPTTTTVPLDQTQLLDELVEVPVLTHTVTPAPLQPKAAPTNFA LDQTQLVDELVTVPLTHTLVNESAPVTPVVVTSPAAEHSFSITTVDKANLTNALSQTVVIKPAEDSAHQSAVLDK EIATKQAQLQQLQAQIELRQAQLETPPVTYMGVEEYKLLPVQDVVPVQPTVSFEMTLLQEQLDKALKHNAALQIQ LEEQLAKPLQYDQSPVLQERIELLQNQNTNLTQELNELQQKLFKSQNNSLLLARLEEENRTLKQHLQNNLPEANQ LNFVLEKQLEQLQQDKHSLTLQIEQYKFDSKKHQEQLALIPSLRSEINSLETEVISLKQTNQRLSLIERENNFLK TEIKQLRETKLNDENTKYRNLLKQYELMRADSDAKLKELEHEQHLAHQHHQEQLAQLQRHNEALVKELDQVKATN FELGLAAQGFEQQKVVLEQKNSSLLASLQAAEENVQALGITNSELQNQLNVLEFTHKEKTAFDSKTLTLTKQQLE QTQFDLSLTQEQLATFKQQNQSLTDKLMASETQLNHLQQSDENLTQLQTQHELLQESYNKLQDEANHTQQQFHQA QNELDAAHQQLALFKQNNEELTDKCSNIQNELHDLNRVKTNWENLNTEHNLLQDKYAQQKEQMQHEHSNLAQIQA EHELLQESYNKVKAELNEIQITNLNEANAQYQDLLSAYELLQSNHNKLKQELQVLNQVNLEKQQLAQKLHNTHQS LSQTHAELTQLQAAYNNLQATPPVSDELLEQFNQVQLEKQRLLQQNLALVHELQYFNELNSSQTHEIKTKQDETV KEVIIVEKEIPVPPEKKPRLKKRDIVIENKEDALGKLSKKERIQAYAERLAKINGKQ Mycoplasma pneumoniae NYSGXRC-6097a SGX Pharmaceuticals 2003-11-05 active Selected EC3861 MRNDPFQRLGLDREVLTVSQLNQRARLLLEDVFPQVWVEGELSNLARPASGHVYFTLKDSNAQIRCALFRQNALRV RQALRDGLAVKVRGKISLFEGRGDYQLIADTVEPAGDGALRLAFEALKEKLAGEGLFASERKRPLPAHPRRIGIV SSPSGAVIRDIISVFRRRAPQVELTLVPTAVQGREAVAQIVRALQLADRQGFDALILARGGGSLEDLWCFNEEAV ARAVAACATPIVSAVGHETDVSISDFVADVRAPTPSAAAELLAPNAGDLQQRLDGLRRRLVLRMRDQLLRERLRL EGVARRLRHPGERLRQQAQRLDDLDMRLRRAFERQLAVRHERLVRLETRLAAQHPGRTLALLRQKLDSLAARLPR AAREVLKDRRQRLEGLAQTLNVVSPLATLGRGYSILLDERGRAIRDAGQTQPGQRLKARLAEGELEVRVEDNHRT PVTLSLLD Pseudomonas aeruginosa NYSGXRC-6097b SGX Pharmaceuticals 2003-11-05 active Selected EC3861 MPSYTLTQLASAVRNCLESGFPGRYWVSAETSGVRVGISGHCYLELLDKDTSGSQVTARMKAMIWASDYATLSGRF QRETGETFDSGLHVLVLVSVSYHEQYGLSLRILDIDPSYTMGAMARKRKEIIEELRRQGLYDLNRSLSLPRPTQR IAIVSSGAAAGFEDFIAHLSHSAEHFCFYPVLFQAVMQGAQTEASVLGALERIAYHRDSFDVVVIIRGGGAVSEL AAFDSLAIGQACARFPLPILTGIGHDRDETVVDLVAYRSLKTPTAVADFLVNCQREEWKLIDDLRSRAAEGLRMM MMYCHERLIQLSLRTPAILKSSVREEHHRIKSVEDRIRLAAKQRIAFGLQQLQIASRSLPALMKSELKQNTGQLD QVAARLPLLVTANLKNYNRRLETNEQAIRLLHPNATLRRGFAIVLKDDKAIRSHSELHKGDHLVAQFADGSVSAV VDQPQKGKH Porphyromonas gingivalis NYSGXRC-6097c SGX Pharmaceuticals 2003-11-05 active Selected EC3861 MAVRDCPECHGTGKIKVGEKECPVCHGWGYVPADFKLGEHLKGYRNLKNLGVEEEVDEIPCPECHGKGTVPVYDTC PTCGGTGKVLVCDICGRIKGPWEPGMETTWVCPECERKFKVVYVLDNACDYEDVEVGKYYKGIIDRVERFGVFVR LNKHVLGLIKKKDLLGKRQYIPGEEIIVQVLDVRPDRKEIDFLEAPLTRYREVQVKKELPVTLIGDLREELAGKT VKVRGKVTQVQVTGGPTVFTLTDGTGITWAAAFEAPGVRAYPNVNIGDVVEVIGKVSFHAGRIQIEIVDMHRIWG PEALEVKKRIEEELDKKAQPKDVGFLVKSEVLEALKPKIMKAAFMIRRAIFEGRPIILRHHADTDGYTAGVALET AIVPLIEEVAPDPDARWHLFKRRPSRAPFYELEDVLKDIIFMMEDHMRFGDELPLVVIVDNGGTTEDIPAYKRLK AYGVKIVVIDHHDPRDWISEDKAKVDEYVDVHVNPHHVKRGYYELTAGMLATEVARYVNPAVEDKIKHLPAIAGT GDRSKAPEFYQYLEYAKEKGLTEEDLKKIAEVIDHEAFYWKFMDGRGIIEDILLVTGNLQRHRMLVDSIYSEVKE KQEKVLRAVLPHVKSVVLPNGIRFNTIDVELYAPKFDYPSPGKLSGLIHDHFKEKYGEESPILTLAYGPDFAVVR ASDGMAKYNFDLNKIVKILAEKLPDAGVEGGGHSYAGSIKFFEGKRKEVLEAFAKEIFKLKAGE Pyrococcus horikoshii NYSGXRC-6097d SGX Pharmaceuticals 2003-12-02 active Selected EC3861 MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAMFKPKSQWLTFQPREGL RVLARGRLTLYEARGDYQIVLDHLEEAGEGALRRAFEQLRIRLEAEGLFDPARKQPLPVHPRRIAVITSPSGAVI RDIFSVLMRRFPLVEIELLPSLVQGDTAAAQITHLLRCADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAA HTPVISAIGHETDFTLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLRL QARNPEMHLRLLAQRQAEAGRRLEQCLHHVLDRAQGQLRNHHTRLYALNPRQQIAGLQQHLKHLNPQQPLQRRLQ QEQLRLHGLVRALEAVNPLATVARGYALVHRADNNTLVRDSAQVCVGDVLDTKLAHGQLRVRVEVSST Xylella fastidiosa NYSGXRC-6097e SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC3861 GENBANK NP_269578.1 MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKI NVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRD IITTVSRRFPGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQL PVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVI FRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQY DSQLARFEKAQDALLSLDASRIIARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI Streptococcus pyogenes NYSGXRC-6097f SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble EC3861 GENBANK NP_814715.1 MTQQYLTVTALTKYLKRKFDADPYLGRVYLTGEISNFRFRANAHQYFSLKDDHAKISAIMFKSAFQKLKFQPKEGM KVMVVGRISLYENSGSYQIYIEHMEPDGVGALYQALAELREKLGKEGLFEGPKQQLPRYPKRIAVVTSPSGAVIR DIITTVKRRYPIAQLVLFPTLVQGEQAADDIVRNIQRADAQSDFDTMIIGRGGGSIEDLWPFNEEKVARAIHAAT TPIISSVGHETDVTIADMVADVRAATPTAAAELAVPVLNEELLRISERRSRLEQSFLYLLQQRTERFQRLQNSYV FKQPERLYEGQTIKLDRMTQRLFQAMTTIHHQKQRQAQGIIAQLQQQTPKGQLRESQQQLAFLQRNLQTQMTQLF LNKQKQFTSAVQQLDLLSPLKIMGRGYSYTTKEDRVVKTVTELQPADQLTIHYADGTVQANVETITAKKEEF Enterococcus faecalis NYSGXRC-6097g SGX Pharmaceuticals 2004-02-17 active Selected Cloned Expressed EC3861 GENBANK NP_438559.1 MSDNIYSVSQLNSAARQMLEGNFCQIWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFRMKNLRVAFRPQNGMQV LVRANVSLYEPRGDYQLIIDSMHPAGEGLLQQQFEALKMKLAAEGLFAQNLKKTLPHFSKAVGIITSSTGAALQD ILHILARRDPSLKVVIYPTAVQGKEATAEIVQMIELANARQEVDVLIVGRGGGSLEDLWCFNEEEVARAIFRSTL PIISAVGHETDVTIADFVADLRAPTPSAAAELVSRNQDELLQQLRHQQQRLDMAFDRLFTRKSQRLKQLALRLQN QHPQNQLRAQQAKNEQLTHRLQLAILRQFENTQQKFTALSVRLKQNPLPYRIQRYQQGLEQLKVRLNFCVNRQVT ERQNKLATLCGKLDGLSPLKVLARGYSIAENPQGKAIVSVKDVNQGDFITTQVADGKIVSKVL Haemophilus influenzae NYSGXRC-6097h SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3861 MTDATVGDEAAAPTVVRLDASCTTQEVEAGEYYHATVNGVVEYGAFVDLSEHVSGLIHESTYSGDPDLAVDDDVIV HLSAVRDNGDLSFEFVDPEEYRTEQRSHAYERTTADAVGSRIGDTVHIEGEVVQIKQTAGPTVFRVRDETSAIPC TAFEDAGVRAHPGVEVGDIVHVSGDADDREGTTQLEVDAFEVLSGGDSADVARRLDAALAEQADPVDVDALVDWP ALEQLLPDLRSVARTLRRAVLEGRPIRMRHHADGDGMCASLPVQYALRQFIEDTHQDEDAARHLLKRLPSKAPYY EMEDATRDLNFALEDRARHGQKLPLLLMLDNGSTEEDTPAYKTLDNYDIPIVVVDHHHPDPGAVDPLVDEHVNPY LHGEDYRITTGMLCVELARMIYPGITSDLEHVPAVAGLSDRSKADAMTDYLDLARDAGYDESFLQQMSEALDYEA YMLRYDHGTQVIADILNVDGDAQRHRELVPFLDRLASEAVAEQLDATRSHVEHERVASGANLYRIDVENHAHRFT YPRAGENNRRDPRPQGRGNRGAGDHHRLRPGLRGAPVGRRAPGHPHDGRRTQRRTPWGRRLRRRPPGRRLDPVRS RDA Halobacterium sp. NRC-1 NYSGXRC-6098a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3870 VTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSLTVTCSRDLVLSAPVKL AEGVQVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRA SAAERDVTTVASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRA IAACRTPVVSAVGHEPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQL RSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEG GSEPQVLRSVHDAPEGTKLRVRVADGALAAVSEGQTNGL Mycobacterium tuberculosis NYSGXRC-6098b SGX Pharmaceuticals 2004-01-07 active Selected Cloned Expressed Soluble EC3870 GENBANK NP_294618.1 MIKGKELLGRPVVAVSNGAQVDNVHDVVFDHQGNRVLALLVEEGGWLRAAKAVPFGRVQSIGEKAVMIATPEDVVN TGRDPVLKEALAGKTNLIGMTLLTTDGQTLGKITDVYFDERSGQVEGYEASGGLFADMTNGRTFIPAPQSIQIGK DSAIVPAGVAAAMREQAPGGIRGAFHTAGKSLGGAVQGAADSVRGAYEDTSRSVRENYEQVSANVAEAAREGQQQ ARAAASDLRSRVQGGAEDLREASAERQKDFVVGKVAGQDVRTDNGVLIVAKGTTIDEGQARFAEQNGALPALLAA AAGGSVREGVRDLLADPSSDAGDVVGRRVQEDVRSSVGSLIAVQGQIVTPEVAERARELGLEERLVAATQAPGLQ TPPVPDRAELREQASDLRDNLADGLSNVSQNVSQGANELLGRAKSWLGERREDLEDSLDRQEQEAYQARIRDALG RPVTRAVLTRTDRVILQPGELVTHAALDEARAAGVLGLLLDSVDGGAPLS Deinococcus radiodurans NYSGXRC-6099a SGX Pharmaceuticals 2004-02-16 active Selected EC1026 MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRGHIYFTLKERKGRMQSVMFARQSERLPFKPENG MKVLVRGGISVYEPSGNYQLYAKEMQPDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAA VRDVITTLKRRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEEIVARAIFA SNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTAEVRMTRAMQQHLGQEKGRIQTLQSS YAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLDRKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNI QMKQLHSQFQTVLGKLNALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK Bacillus subtilis NYSGXRC-6099b SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC1026 MLSSQTSSIFTVSRLNQTVRLLLEQEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQH GQQVLVRANITLYEPRGDYQIIAESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQHKQPLPSPAHCVGVITSKTGA ALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANARGECDVLIVGRGGGSLEDLWSFNDERVARAIF ASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEIVSRNQQELLRQIQSAQQRLGMAMDYYLANRSRRFTQIFH RLQQQHPQLRLARQQTALERLRQRMGFALEARIKQANQRQQCVSQRLSQQNPQPRIHRAQSRIQQLEYRLTENIR SRLSEQRERFGNAVTHLEAVSPLATLARGYTVSTTTDGKVLKKIKQVKAGDIMTTRLEDGWLESEVKSVTPGT Salmonella typhimurium NYSGXRC-6099c SGX Pharmaceuticals 2004-01-26 active Selected Cloned Expressed EC1026 MAGHQPILTVSEVTRHLKRTIEDDPLLQDVWMRGEISNFKHHSRGHMYFTLKDEHAKMSAVMFAGNNRFLNFKPEN GMKVIVRGEVNVYEPFGQYQLYALEMQPDGIGNLYLAYEQLKERLEQEGLFKEENKKPLPPVARQIAIVTSPTGA AIRDIASTIKRRFPVAQLTLLPVLVQGEEAPHSIAKAIRQANEVGGFDLLIVGRGGGSIEELWAFNEELVARAIY QSVIPIISAVGHETDYTIADFVADVRAATPTGAAELAVPDLKELISRVNQYTERLKRAQHELLKRQKEHLQRLQK SYAFRYPAQLVKQKELELDQQLERLTKHQRRMVSDAKDRLSQLEYRLKRIHPEGRLRQAEQARVKLEVLLKKEFQ QMMERKEQQFQQAISSLNLLSPLRVMERGYALPYKAKTQELIKSVKQVRMNDRLHLRVTDGQLICDVKEIESESG GEGYDQK Bacillus halodurans NYSGXRC-6100a SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC1028 GENBANK NP_417004.1 MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSSRRVTFRPQH GQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQYKKPLPSPAHCVGVITSKTGA ALHDILHVLKRRDPSLPVIIYPAAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIF TSRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSTRQRLEMAMDYYLANRTRRFTQIHH RLQQQHPQLRLARQQTMLERLQKRMSFALENQLKRTGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAETLR AQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIESEVKNIQPVKKS RKKVH Escherichia coli NYSGXRC-6100b SGX Pharmaceuticals 2003-11-05 active Selected EC1028 MAADFAASVILDTALSVSGLTDYLRLLLEHDEQLRQVWVVGEVSSTNHHRSGLFFTLQDPDGSAAIKCVVWSSQVP KLAQLPVAGEQLIVLGSIRLYPQRGEYQLSVWQAVPAGVGLQALRYQQLKNRLLAEGLFDPQRKRSLPIHPQTIA VVTSPTAAAWGDIQKTLKHRYPGLHVLFSPATVQGEQAPESIVKAIARVEKDGRAEVLILSRGGGAVEELACFND ERVVRAVAECSIPVVTGIGHQRDESLVDLVADVCVHTPTAAAEKVVPSLAELSNQHRQRIIALHQVLLHTQTSAE NQLQTLRNRLQNLRLDRHLQQEAQKLNWQRQRLLQLTMGRSQQAKQHLELLRQKLISLDPKSVLQRGYAVVRQEN GAIARSADELAVGNELFIQLAQGEVKAKVIEVEQRQ Nostoc sp. NYSGXRC-6101a SGX Pharmaceuticals 2003-11-05 active Selected EC4265 MQHKRSRAMASPRSPFLFVLLALAVGGTANAHDDGLPAFRYSAELLGQLQLPSVALPLNDDLFLYGRDAEAFDLEA YLALNAPALRDKSEYLEHWSGYYSINPKVLLTLMVMQSGPLGAPDERALAARLGRLSAKRGFDAQVRDVLQQLSR RYYGFEEYQLRQAAARKAVGEDGLNAASAALLGLLREGAKVSAVARRQSARAYAQTFQRLFGTPAAELLQPSNRV ARQLQAKAALAPPSNLMQLPWRQGYSWQPNGAHFEHGSGYPYSSFDASYDWPRWGSATYSVVAAHAGTVRVLSRC QVRVTHPSGWATNYYHMDQIQVSNGQQVSADTKLGVYAGNINTALCEGGSSTGPHLHFSLLYNGAFVSLQGASFG P Pseudomonas aeruginosa NYSGXRC-6101b SGX Pharmaceuticals 2004-02-24 active Selected Cloned Expressed Soluble EC4265 GENBANK NP_212389.1 MLKSMYRIQKALLILCILGIENINSEIINTIPKVQYKKEAFQGDYIYFASNQNFKSLSLLSTNKNPIISSSPFKFT VGSKIYYIALMGITPMIKEGKRKIQIEFENKSYIKEIEIKKFHFKKTKISFNKEKAKLITQKKSTKQKEQALVLW NIIGNTGDTTIYHYDALVKPIKDQYIVTSLYGDLRLYMQGDKKISNYTMHNGIDYAPFKRENTPIFAAGKGKVVF AQNRELTGNTLIIQHLPGVFTIYLHLSKLGISENKIVSAGEYIGHTGNTGLSTGPHLHFEVRINGIAINPDFLLN GMLIDKNKIINNIKRIE Borrelia burgdorferi NYSGXRC-6102a SGX Pharmaceuticals 2004-06-01 active Selected Cloned Expressed Soluble EC4300 GENBANK NP_249358.1 VFPSSEVEAKRTTLNLELESNTDRLLQEKDDLLPQSVTNSSDEGTPFAQVEGASDDNTAEQDSDKPGASVADADTK PVDPEWKTITVASGDTLSTVFTKAGLSTSAMHDMLTSSKDAKRFTHLKVGQEVKLKLDPKGELQALRVKQSELET IGLDKTDKGYSFKREKAQIDLHTAYAHGRITSSLFVAGRNAGLPYNLVTSLSNIFGYDIDFALDLREGDEFDVIY EQHKVNGKQVATGNILAARFVNRGKTYTAVRYTNKQGNTSYYRADGSSMRKAFIRTPVDFARISSRFSLGRRHPI LNKIRAHKGVDYAAPIGTPIKATGDGKILEAGRKGGYGNAVVIQHGQRYRTIYGHMSRFAKGIRAGTSVKQGQII GYVGMTGLATGPHLHYEFQINGRHVDPLSAKLPMADPLGGADRKRFMAQTQPMIARMDQEKKTLLALNKQR Pseudomonas aeruginosa NYSGXRC-6102b SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC4300 GENBANK NP_347883.1 MGNYNSQYENYYRNLQNRSIRTSSYYKSSGFNRKNLGEKIIKKIEFQLIGTLVLFLAVFSLREVITPETKAACNYI KYTVSYNYDYSQILSYIEGFNLNDVETYASKIDMDSLKNQSVDYIENLKARVTGEKTFGAKIKQEYCLPINGKIA SHFKQKDKDVLGNQYLNNGVDIKANSDLDVKAIYDGTVEKVGEDKDFGKYVMVDNGDGVESKYSNMDSFEVQRGD GVTKGEVLGKVKKNDDASKSYLHFEIMYMGENQDPENYFTFK Clostridium acetobutylicum NYSGXRC-6102c SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC4300 GENBANK NP_212396.1 MIIPKKKQRVEKRKKNFLFNSKKSVNFELKDFANISNIGKRRKKVFKIKNFFKKKINFFKKVSLFFYKLKIQNINH YEYKYYYKSLRDKVFDIFSVRFDYKLVFKLNAIIFIFILTFYINIFSYYGSYVFLNRLSLPKDYFIDTFLYYSDQ DIAQISSYLPESNVSANVPGFKKNFVLKVFDHKIKPGETLSHVAARYQITSETLISFNEIKDVRNIKPNSVIKVP NMKGIVYIVKKNDSISSIASAYNVPKVDILDSNNLDNEVLFLGQKLFIPGGRLPKDFLKEVLGETFIYPVQGVIT SGYGYRPDPFTGVISFHNGIDIANLANTPIKASREGVVVTAGFNAGGYGKYIVISHSNGFQTLYAHLNSFAVKVG KKVSRGAVIGYMGSTGYSTGNHLHFTIFKNGKTENPMKYLR Borrelia burgdorferi NYSGXRC-6102d SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified EC4300 ICEDB: T2211 GENBANK ZP_01068610.1 MKKLLLLFIFVVQSFAALSVEELTWDNGDTLLKFLQRNSIPMSLYYGLDREDQELASDIAYKIKYQVLKDENNNIE QVLIPISDDLQIHIYKDKDGQYTLAFTPVSYQKEDRILHLTIKSSAYQDVYEESGSSTLARAMVRAFRGSINFRN IQKGDEVTLYYEQKRRMGKLWGDINIKMAMVEINKSAREVFSYNDIFYDRDGKELESFLLTKPVNYTRISSPFTT ARYHPILKRYRAHLGIDYAAPTGTPVKSAGKGVVTFIGTKGGYGNVIQIKHDSGYMTLYAHLSRFAKIKNGQKVN QGQVIAYVGSTGMSTGPHLHFGVYLNNKAINPASVVKIAKSELSGKAKENFKHIIAGYEQVVKEALASNQPNPPK EEDFENYIEF Campylobacter jejuni NYSGXRC-6103a SGX Pharmaceuticals 2004-03-15 active Selected Cloned Expressed Soluble EC2482 MKHQETTSQQYNFSIIKHGDISTPQGFTAGGMHIGLRANKKDFGWIYSSSLASSAAVYTLNQFKAAPLIVTEDTLQ KSKGKLQALVVNSANANSCTGQQGIDDARQTQTWVAQQLQIPSEHVAVASTGVIGEYLPMDKIKTGTEHIKDTNF ATPGAFNEAILTTDTCTKHIAVSLKIDGKTVTIGGSAKGSGMIHPNMATMLAFITTDASIESNTLHQLLKSSTDH TFNMITVDGDTSTNDMVLVMANHQVEHQILSQDHPQWETFVDAFNFVCTFLAKAIARDGEGATKLISVNVSGAKS ISDARKIGKTIVSSNLVKSAIFGEDANFGRIITAIGYSGCEIDPKCTYVQLNQIPVVDKGMAVLFDEQAMSNTLT HEHVTIDVQLGLGNAAATAYGCDLSYDYVRINASYRT Staphylococcus aureus NYSGXRC-6103b SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC2482 MELIKGNIASPKGFYADGKHAGLKRKRNDIGWIYSEVPANAAAVYTMNQMQAAPIFVTKDSFQSNAKLQAIIVNSG NANACTGNQGMLDALAMRAQTAEKLEIPLDSVAVASTGIIGDMLPMDKINAGIEMLEKQTGNAADFEEAILTTDT FQKQISFQTEIGGRKVTMSGVAKGSGMIHPNMATMLAFITTDAAIPAELLQKLLKIKVDKTFNQITVDGDTSTND MVVVMANGCAENPMLQEGTADFAKFADMFQAVTEHLAKSIARDGEGATKLIEVQVNGATKTEDARMIAKKIVSSS LVKTAAFGGDGNWGRIICAIGYSGGRFAPDNITIKIGGIEILNHSSQTIYNQQALDAYLEEEHIIIEVDLHIGLE SGTAWGCDLSYEYVKINACYRT Listeria monocytogenes NYSGXRC-6103c SGX Pharmaceuticals 2004-06-01 active Selected Cloned Expressed Soluble EC2482 GENBANK NP_721092.1 MKIIDGNIASPLGFSADGLHAGFKKRKKDFGWIVSEVPASVAGVYTTNKVIAAPLIVTRESVKKAQKMQALVVNSG VANSCTGLQGMEDAYTMQKWTATKLKIAPELVGVASTGVIGDLMPMDTLQKGLSKLVVNGNSDDFAQAILTTDTK VKTVAVTEQFGRDEVTMAGVAKGSGMIHPNMATMLAFITCDAVISSETLQLALSQNVETTFNQITVDGDTSTNDM VLVLSNGCTLNKEILPDTPEFDKFSAMLHFVMQELAKKIAKDGEGATKLIEVEVINAPNSLDACMMAKSVVGSSL VKTAIFGEDPNWGRILAAVGYAGVDVPVDNIDIYLADIPVMLASSPVDFDEEDMQDVMRADTIKIIVDLHAGDSV GKAWGCDLSYDYVKINALYRT Streptococcus mutans NYSGXRC-6104a SGX Pharmaceuticals 2005-02-23 active Selected Cloned Expressed Soluble Purified EC1731 ICEDB: T2205 GENBANK NP_288871.1 VSRIIMLIPTGTSVGLTSVSLGVIRAMERKGVRLSVFKPIAQPRTGGDAPDQTTTIVRANSSTTTAAEPLKMSYVE GLLSSNQKDVLMEEIVANYHANTKDAEVVLVEGLVPTRKHQFAQSLNYEIAKTLNAEIVFVMSQGTDTPEQLKER IELTRNSFGGAKNTNITGVIVNKLNAPVDEQGRTRPDLSEIFDDSSKAKVNNVDPAKLQESSPLPVLGAVPWSFD LIATRAIDMARHLNATIINEGDINTRRVKSVTFCARSIPHMLEHFRAGSLLVTSADRPDVLVAACLAAMNGVEIG ALLLTGGYEMDARISKLCERAFATGLPVFMVNTNTWQTSLSLQSFNLEVPVDDHERIEKVQEYVANYINADWIDS LTATSERSRRLSPPAFRYQLTELARKAGKRIVLPEGDEPRTVKAAAICAERGIATCVLLGNPAEINRVAASQGVE LGAGIEIVDPEVVRESYVGRLVELRKNKGMTETVAREQLEDNVVLGTLMLEQDEVDGLVSGAVHTTANTIRPPLQ LIKTAPGSSLVSSVFFMLLPEQVYVYGDCAINPDPTAEQLAEIAIQSADSAAAFGIEPRVAMLSYSTGTSGAGSD VEKVREATRLAQEKRPDLMIDGPLQYDAAVMADVAKSKAPNSPVAGRATVFIFPDLNTGNTTYKAVQRSADLISI GPMLQGMRKPVNDLSRGALVDDIVYTIALTAIQSAQQQ Escherichia coli O157:H7 NYSGXRC-6104b SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC1731 VLYSFYKVFCLKDYVFKKARIFVKENKLKANIVFPESSDSRVLKAAIVILQKNLADSIILIGKKDTVINSLKEFSN CNDILGRIEVVDPNSFPDIEMYLDEYWSLQKLKGVTKQSLKTQVLDEITFAMLMVRFGYAKSCVCGAVSTSAKVL SNALRIIPKLEGVKIISSFMIMDTLCTRNVDFCFGHNGILFFADCSVVVNPNSLELAEIALQSAKSFKDILNAKP KVALLSFSTKGSSSAKETEKVKNALNIVRNKESDLLIDGELQLDSAIIKDVAEKKCRESLVAGSANVLIFPNLDA GNIGYKLVERFAFAKAYGPFLQGFSKPISDLSRGCSVDEIVFASALMISI Borrelia burgdorferi NYSGXRC-6104c SGX Pharmaceuticals 2004-01-26 active Selected EC1731 MSNDTFKQAAIDYHCTQPAGKIKVVATKPMLTQRDLSLAYSPGVAFACQAIVENPQQASELTARGNLVAVISNGTA VLGLGNIGPLAGKPVMEGKGVLFQKFAGIDVFDIEIDESDPDKLVDIIASLEPTFGGVNLEDIKAPECFIVERKL RERMSIPVFHDDQHGTAIIVGAAVLNAMVITGKKIGEVKLATTGMGAAGVSCVNMLVSLGLNPDNILAYDREGVI HTGRTDLDPEKQRYARDTDKRTLAEIVEGADIFLGLSAAGILTPEMVATMAPDPVIFALANPIPEIMPEAVCAVR TDAIIGTGRSDYPNQINNVLCFPYLFRGALDVGATTINEEMKIACVKAIAALARCEASDLGAAYGGETPSFGREY LIPRPLDPRLLVELSSAVAQAAMDSGVATRPITDMSAYHDKLSQFVYRTSLMMKPVYDRARADKQRVVYAEGEEE VILRAVQNVIDEGLAFPILIGRPDVIESRIQRMGLRMKAGVDFEVTNIHDDPRFNDYWQYYHGVTERRGVTVSAA KELMRSRPTLIASVMVARGEADALLTGAVGRFHKRLGYARSVIPLEPRVSSTAAMTGVINQHGAFFFVDTHVQED PSAEQIAEATLQACYRLKLFGIEPSVALLSHSNFGSHDSRDALKMRQVRELLLKRSPRLNIDGEMQADTAWDEVL RERIMPNTTLKGRANLFVFPNLEAANIAYNLVRVFTDGVAIGPILMGISKAVHILTSSTTSRRVMNMTAIAAVDA QIRKQFEGGKRGG Xylella fastidiosa NYSGXRC-6104d SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble Purified EC1731 ICEDB: T1700 GENBANK NP_465627.1 MSDLFTTIKGQVTGKNVRIVLPEGTDERIVGAAARLQKENIVKPILLGNKAEIEAKAKEIGVSVEGIAIHEPATDP LFDELVAAFVERRKGKATEEAARKMLVDPNYFGTMLVYTGKAEGLVSGAAHSTGDTVRPALQIIKTKPGVSKVAG AMIMVRGEERYLFSDVAINIAPVAADLAENAIVSAETAEIFGIDPRVAMLSFSTKGSAKSDETEKVVEATALAKE KAPELTLDGEFQFDAAFVPTVAEKKAPGSVIKGDANVFIFPSLEAGNIGYKIAQRLGNFEAVGPILQGLNAPVND LSRGCNTDDVYNLTLITAAQAVNK Listeria monocytogenes NYSGXRC-6104e SGX Pharmaceuticals 2004-01-26 active Selected EC1731 MTVEDMTSHDKNNTPANTAKADIEEQALFFHRYPRPGKLEIQATKPLGNQRDLALAYSPGVAAPCLAIHENPEMAA EYTARANLVAVISNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIEIDAPGINDMVSTIAALEPTFGGI NLEDIKAPECFEVERQLREKMNIPVFHDDQHGTAIIVAAAVTNALELAGKSLSSVKIVASGAGAAALACLNLLVA MGANKENIWVHDIEGLVYEGRNTLMDEWKEVYAQKTDKRVLADSIDGADVFLGLSAAGVLKPELLERMAENPLIL ALANPNPEIMPEAARAARPDAMICTGRSDFPNQVNNVLCFPYIFRGALDCGATTINEEMKMAAVQAIAELAREEV SEVAARAYSGETPIFGPNYLIPSPFDPRLILRIAPAVARAAAASGVATRPITDFEAYFDQLNRFVWRSGFIMKPV FNAAKAAEKKRIIFAEGEDERVLRAAQVLLEEGTGVPILIGRPQIIETRLKRFGLRIRPHADFAVVNPEDDPRYR EYVDDYFALVGRAGINPEAARTIVRTNSTVIGALSVKRGEADALICGLEGRYDRHLRDVNQIIGKQESVRSFAGL SLLITQQGALFLTDTFVNNDPTSEEVAEMAILAAKEIRRFGITPKIALASHSNFGSRDSESARKMRRALKIIQQA APELEVDGEMQGGSALSEALRKRAMPNSVLTGEANLLVFPNLDAANITLGVTRTLTEGLHVGPILLGTALPAHIL SPSVTSRGVVNMAAFAVVQASHPSV Agrobacterium tumefaciens NYSGXRC-6105a SGX Pharmaceuticals 2004-04-02 active Selected EC2544 VTKPAADASAVLTAEDTLVLASTATPVEMELIMGWLGQQRARHPDSKFDILKLPPRNAPPAALTALVEQLEPGFAS SPQSGEDRSIVPVRVIWLPPADRSRAGKVAALLPGRDPYHPSQRQQRRILRTDPRRARVVAGESAKVSELRQQWR DTTVAEHKRDFAQFVSRRALLALARAEYQILGPQYKSPRLVKPEMLASARFRAGLDRIPGATVEDAGKMLDELST GWSQVSVDLVSVLGRLASRGFDPEFDYDEYQVAAMRAALEAHPAVLLFSHRSYIDGVVVPVAMQDNRLPPVHMFG GINLSFGLMGPLMRRSGMIFIRRNIGNDPLYKYVLKEYVGYVVEKRFNLSWSIEGTRSRTGKMLPPKLGLMSYVA DAYLDGRSDDILLQGVSICFDQLHEITEYAAYARGAEKTPEGLRWLYNFIKAQGERNFGKIYVRFPEAVSMRQYL GAPHGELTQDPAAKRLALQKMSFEVAWRILQATPVTATGLVSALLLTTRGTALTLDQLHHTLQDSLDYLERKQSP VSTSALRLRSREGVRAAADALSNGHPVTRVDSGREPVWYIAPDDEHAAAFYRNSVIHAFLETSIVELALAHAKHA EGDRVAAFWAQAMRLRDLLKFDFYFADSTAFRANIAQEMAWHQDWEDHLGVGGNEIDAMLYAKRPLMSDAMLRVF FEAYEIVADVLRDAPPDIGPEELTELALGLGRQFVAQGRVRSSEPVSTLLFATARQVAVDQELIAPAADLAERRV AFRRELRNILRDFDYVEQIARNQFVAREFKARQGRDRI Mycobacterium tuberculosis NYSGXRC-6105b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2544 GENBANK NP_249049.1 MSGNYLPRNTLVESLGHAMLKLSGWKIEGQLPALDKFVVIGAHHTSNWDFVAFLAAKFVLRLNARWFGKHTLFNGP LGGLMRRWGGIPIQRHLKLNTVDQAIQAFREHREFMLIIAPEGTRKKVDRWRMGFYHIARGAGVPVVPAALDYEN RRIVIGEPFWPTGNEDADLCSLIGFYRPFIPKKPHYAFLGD Pseudomonas aeruginosa NYSGXRC-6106a SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC4285 MMSSRVTIFTSCNDAYIYLLREGNSQAFPNAVGSKMVNLNTIPPKNGRDYYIALGLEGSANKLGVGIVKHPLLPKH ANSDLSYDCEAEMLSNIRDTYVTPPGEGFLPRDTARHHRNWCIRLIKQALAEADIKSPTLDIDVICFTKGPGMGA PLHSVVIAARTCSLLWDVPLVGVNHCIGHIEMGREITKAQNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGN CLDRFARTLKIPNEPSPGYNIEQLAKKAPHKENLVELPYTVKGMDLSMSGILASIDLLAKDLFKGNKKNKILFDK TTGEQKVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQEMMAQMCKDRANGQVHATDNRF CIDNGVMIAQAGLLEYRMGGIVKDFSETVVTQKFRTDEVYAAWRD Saccharomyces cerevisiae NYSGXRC-6106b SGX Pharmaceuticals 2004-01-26 active Selected EC4285 MIVLALDTSGVDCSACIYDNASDTVLGEVCETIGKGHAERLMAVIDGALQQAQLPLQKVERIAVTIGPGSFTGIRV GVAAARGFALSLGVEAVGVTTLETLALHHLAENPGRPVAVGLDAKRGETYLQIFGTDGSPLNEAALLSLDDAKDA LSGFDGAVIGSAAPLFAGEETGSGPDHFPIAFVARAGARKSAGQPKPAPLYLRGPDARPQTGFALARQDVA Agrobacterium tumefaciens NYSGXRC-6106c SGX Pharmaceuticals 2004-03-08 active Selected Cloned Expressed Soluble EC4285 MIDRYILAIESSCDETSVAILKNEDQLLSNIIASQVESHKRFGGVVPEVASRHHVEVITLCIQDALQEAGITAGDL SAVAVTYGPGLVGALLVGMAAAKAFAWANHLPLIPVNHMAGHLMAAQSIADLQYPLLALLVSGGHTELVYVAAPG DYRIVGETRDDAVGEAYDKVGRVMGLTYPAGKEIDQLAHQGQDIYDFPRAMIKEDNLEFSFSGLKSAFINLHHNA RQKGEQLRLEDLCASFQAAVLDILMVKTKKALAAYPVKTLVIAGGVAANQGLRERLKEDIKDINVVIPPLRLCGD NAGMIAYAAAVEYEKGHFAELDLNAKPSLAFEGLE Streptococcus mutans NYSGXRC-6106d SGX Pharmaceuticals 2004-03-16 active Selected Cloned Expressed Soluble Purified EC4285 ICEDB: T1692 GENBANK NP_816119.1 MTIFTKERKLLLAVESSCDETSVAVIEDGDKILSNIVASQIKSHQRFGGVVPEVASRHHVEQVTICIEEALTEAKV TPEELSGVAVTYGPGLVGALLIGLSAAKAFAWAHQLPLIPVNHMAGHIYAARFVAPLEFPLMALLVSGGHTELVY MKEDGSFEIVGETRDDAAGEAYDKVGRVLGLPYPSGKEIDALAHEGTDTYQFPRAMLKEDNYDFSFSGLKSAFIN TVHNAEQRGEALSTKDLAASFQASVVEVLVTKTIRACQEYPVKQLLIAGGVAANQGLREAMRHAISEQLPAVTLL IPPLKLCGDNAAMIGAAAFIEAEKNHFASYNLNAEPGVSFMTISEEG Enterococcus faecalis NYSGXRC-6106e SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble EC4285 MGKPLIALGLEGSANKLGVGIILHDTNGSAKILANVRHTYITPPGQGFLPSDTAKHHRAWIIPLIKQAFAEAKISF KDIDCICFTKGPGIGAPLNSVALCARMLSLIHKKPLVAVNHCIGHIEMGREITGAQNPVVLYVSGGNTQVIAYSE KKYRIFGETLDIAIGNCLDRFARIIGLSNAPSPGYNIMQEAKKGKRFIELPYTVKGMDCSFSGLLSGVEAAATEL LDPKNPSSVTKQDLCYSLQETGFAMLVEITERAMAHIRADSVLIVGGVGCNERLQQMMAEMSSDRGADVFSTDER FCIDNGIMIAQAGLLAYKTGDRCAVAESTITQRYRTDDVYISWRD Schizosaccharomyces pombe NYSGXRC-6107a SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC3570 ICEDB: T1711 MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQ KQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKL KSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSI PINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQ PNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN Staphylococcus aureus NYSGXRC-6107b SGX Pharmaceuticals 2004-03-02 active Selected Cloned Expressed Soluble Purified EC3570 ICEDB: T1687 GENBANK NP_390898.1 MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIRKHFYGKKVKLNMIMNAKSGLCPENCGYCSQSA ISKAPIESYRMVNKETLLEGAKRAHDLNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQ AKRLKDAGVDRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDIAKSLKALD ADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGREVNLRTLQPLGLYAANSIFVGDYLT TAGQEETEDHKMLSDLGFEVESVEEMKASLSAKS Bacillus subtilis NYSGXRC-6107c SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC3570 MSEITASPRHDWTLAEVEALFALPFMELVFQAANVHRAHFDPSEIQLSQLLSVKTGGCAENCGYCSQSAHFKTGLK ADKLMAADDVVAKARAARDGGAQRFCMGAAWRELKDRDLPKLTEMIGEVKALGLETCATLGMLTADQAKALKAAG LDYYNHNLDTGPDYYKDVVTTRTYQERLDTLAHVRDAGMSTCCGGIVGMGEQRRDRAGLLHQLATLPAHPDSLPI NGLVPISGTPLGDKVLSEGKAIDAIEFVRTIAVARIVCPKSMVRLSAGREGMSRELQALCFMAGANSIFVGGKLL TTPLPGQDEDSQLFQDLDLKPMGGAVRVEAKADAAMVAAE Caulobacter crescentus NYSGXRC-6107d SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC3570 ICEDB: T1694 GENBANK NP_439182.1 MLAEKLQINSITPHPSVEYWSVCKVEALFETPFLELVYRATQVHRKHFNPRAIQLSTLMSIKTGGCPEDCSYCPQS ARYHTGVQNQQLLDVDEIVAKAKIAKARGAGRFCMGAAWRGPKPKDIEKVTEIIKAVKSLGLETCGTFGLLQDGM AEDLKEAGLDYYNHNLDTAPEHYAEVIGTRRFDDRLSTLGKVRKAGLKVCCGGIVGMNETRKERAGLIASLANLD PQPESVPINQLVKVEGTPLADAEELDWTEFVRTIAVARITMPKSYVRLSAGRSGMTEEMQAMCFMAGANSIFYGD KLLVTDNPEEDGDQLLMAKLDLEPETAENKKL Haemophilus influenzae NYSGXRC-6107e SGX Pharmaceuticals 2004-05-25 active Selected Cloned Expressed Soluble EC3570 GENBANK NP_518387.1 MQHAPLNFVPDAAKVPPTPGQSPNARWSREAIEALFALPFNDLLFQAQQVHRAHFDANAVQLSTLLSIKTGGCPED CSYCPQSARYDTGVEAEKLMPIDTVLEAAARAKQNGASRFCMGAAWRNPKPHQLDAVADMVRGVKAMGLETCVTL GMLKQEQAQQLKDAGLDYYNHNLDTAPEFYGEIITTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESRHERAGLV AELANMEPYPDSVPINNLVKVEGTPLAGNEALDPFEFVRTIAVARITMPKAMVRLSAGREAMDDALQALCFMAGA NSIFYGEKLLTTDNPEADADRKLLARLGMRVEVQDHLHQAEGAQHSHSSHCHIDITPAD Ralstonia solanacearum NYSGXRC-6108b SGX Pharmaceuticals 2004-06-04 active Selected Cloned Expressed Soluble Purified EC1702 ICEDB: T1878 GENBANK NP_344186.1 MIYFFMVDAVELSRKYEGKIEIYPKVPITSYNDFALIYTPGVAEVSKAIYKDPDKSFELTSRWNTIAVVTDGTRVL GLGNIGPTAAMPVMEGKSLLFKYLGGVDAIPLPINVKSADEFTNVVKALETSFGGINLEDIESPKCFYILEKLQS MLNIPVWHDDQQGTAAAILAGLINAMILTNKDPKESKVVFYGAGASNIAAARILAKYGFKYENIVMIDSKGPLYA DREDVDHLMLHHKWKYELAIKTNKWEAKEIKDAFSGADAVVAASTPGPNVIKKEWISLMNKEAIVFALANPVPEI WPQDAKEAGAKIVATGRSDFPNQVNNSLIFPAIFRGVLDSRAKAITDEMTIAASEALAKYARDRGINENYIIPRM DEWEAFYEEAAAVASKAVELGLARVKKSREEFREIAKERIIRARKIMNLVISTWSP Sulfolobus solfataricus NYSGXRC-6108c SGX Pharmaceuticals 2005-02-10 active Selected Cloned Expressed Soluble Purified EC1702 ICEDB: T1712 MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGL GNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKET NIPVFHDDQHGTAIVTMAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSY GMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGA RVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVA RNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ Staphylococcus aureus NYSGXRC-6108e SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC1702 MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVISNGTAV LGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQKLR ERMNIPVFHDDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIY KGREPNMAETKAAYAVDDSGKRTLDEVIDGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKEV RPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGP EYIIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIADFDAYIDKLTEFVYKTNLFMKPIFSQARKDPKRVVLPEGE EARVLHATQELITLGLAKPILIGRPSVIEMRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQIMKRRGVTQE QAQRAMIGNHTAIGAIMVQRGEADAMICGTIGDYHEHFSVVKAVFGYRDGVHTAGAMNALLLPSGNTFIADTYVN EDPTPEQLAEIAVMAAETVRRFGIEPKVALLSHSNFGSSNSLSASKMRETLERVRERAPDLMIDGEMHGDAALVE SIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTVGPVLMGVSKPVHVLTPIASVRRIVNMVALAV VEAQTTPL Salmonella typhi NYSGXRC-6108f SGX Pharmaceuticals 2004-05-25 active Selected Cloned Expressed Soluble Purified EC1702 ICEDB: T1879 GENBANK NP_244034.1 VATTREEALHIHRENQGKLESKSKVPVRNARDLSLAYSPGVAEPCKEIFEDVETVYEYTMKGNMVAVVSNGTAVLG LGNIGPEASLPVMEGKAVLFKSFAGVDAFPICLRTTDVDQIVETVKLLEPTFGGVNLEDIAAPSCFEIEERLKKE TNIPVFHDDQHGTAIVTLAGLINALKLTGKRMSEIKVVANGAGAAGIAIIKLMQRMGVRDIIMCDSKGAIYDGRP YGMNDMKAEVAKWTNRDKIDGGLGDVLKGADVFIGVSVAGALTKEMIENMNDDPIIFAMANPVPEIMPEEAKAAG AKVIGTGRSDFPNQVNNVLAFPGIFRGALDARATHINEEMKVAAVHAIADLVAEEDLDPDYVIPAPFDPRVAPAV AAAVAKTAMETGVARRKVDPAEVEAKTKKLAIIE Bacillus halodurans NYSGXRC-6109a SGX Pharmaceuticals 2004-06-02 active Selected Cloned Expressed Soluble Purified EC3362 ICEDB: T1880 GENBANK NP_217493.1 VTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATVLLGPGDDAALVSAGDGRTVVSTDMLVQDSHFRLDWSTPQ DVGRKAIAQNAADIEAMGARATAFVVGFGAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLVSCRQWVVSVTAI GDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAMIDVS DGLLADLRHIAEASGVRIDLSAAALAADRDALTAAATALGTDPWPWVLSGGEDHALVACFVGPVPAGWRTIGRVL DGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG Mycobacterium tuberculosis NYSGXRC-6109b SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC3362 ICEDB: T1706 GENBANK NP_904922.1 MKRTEISSLGEFGLIRHLTDCVRLKNPGTLKGIGDDAAVISFDEGMKALVTTDMLLEGIHFDLTYTPLKHLGYKSA IVNFSDIYAMNGTPRQLTVSIGVSARFSVEDIEQIYQGILTACDAYGVDLVGGDTSASLTGLCLSLTCIGEAREE EIVYRSGAKPTDLICVSGDLGAAYMGLQLLEREKAVYQGEKDFAPDFAGHEYILERQLKPEARKDIVEELRSAGI KPTAMMDISDGLSSELLHIAHAGKVGVRIYDDKLPIDYQTAAMAEEFNMNLSTAALNGGEDYELLFTVPLTRLDD IQRIEGIHLIGHITEEADGHLLVARDGTEITLVAQGWNAAKALNG Porphyromonas gingivalis NYSGXRC-6109c SGX Pharmaceuticals 2004-01-26 active Selected EC3362 MDERAALELVGGLVSRAGDDAAVVGDTALTIDMLHDATDFPSGTTRYTAGWRSVGASLSDVAATGATATAAVAAYG APGFDDDELAAFVTGARDVCTAVGAEYVGGDLDGHSEFTVATAAIGDADHRVTRSGARPGDSVVVTGSLGRSAAA MALFDAGDTERANDLFQFMPRVAAGRVLGAHATAMMDASDGLARSLHQLAAASDCGMAVDSGRLPVADALAEVTA DPVERAVSFGGDFELVAAVPPERVEAARAAVPGSLSVVGRVTAAADGVRLDGDALADDGWTH Halobacterium sp. NRC-1 NYSGXRC-6109d SGX Pharmaceuticals 2004-02-27 active Selected Cloned Expressed Soluble Purified EC3362 ICEDB: T1683 GENBANK NP_241410.1 MRDEFSLIRSISPANVHQPSLHVGIGDDAAIYEGAPEMEEVLCVDTMVEEIHFRRDTLTPFQIGYKSLAINISDLA AMGATPKFYLVSIAVPPQWSDREIKTLYRGMAECAAPYRMDLIGGDTVSTNAKLVVTVTAVGHVPKGTRLLRQRA RPGDVVFLTGTVGQSAAGLELLNKKGLHGPFTEEEELLVLAHQQPQPQVEAGHLFARSGYRIALNDVSDGVASEA NELAEASKVKLVLKANTIPLHPAMETFSKEQQLEWALFGGEDFQLIGTAAVDAFASLQQLAIQRGISLTEIGYVE AGSPVVELEEGTARSVLKKSGYNHFAK Bacillus halodurans NYSGXRC-6109e SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC3362 ICEDB: T1709 VTKMRESEIIRMFIEEFDNHALGDDAGFVRFNDSWLLVTSDMLVWRTDVPDFMTPEEAGKKVVTMNVSDIAAMGGL PLAFFFSLGVPENTDEKTLRGIAKGINKGAKEYGVKIVSGDTNEAREIIIDGGAIGRGSRLLLRSNAKPGDLVCV TGELGRPLTALLLWLKGEEIPPKILEKAKNPKAREREGIELSNYANSAIDISDGLSKELWEIARSSNVRIVIDED KIPVNEEVREIVKDPIKIALASGEEFELVFTIPKENLGNISFDFTIIGRVEEGEGVYIKREDKMERLPILGWEHL KGGDYVNL Pyrococcus horikoshii NYSGXRC-6109f SGX Pharmaceuticals 2004-04-02 active Selected EC3362 VLKPPVPADSAEHLSEFGLIRRYFTRPARHATLGVGDDCALLGPRPGHELAISTDMLVAGRHFFADAEPRALGHKA LAVNLSDLAAMGAEPRAFTLAMALPAADPAWLGPFADGLLALADAFHCELIGGDTTRGPLTLSLTVFGDVPADLA LRRDAARPDDDLWVSGTVGDARLALGALRGEWPLAPEALARVQPRMDAPTPRVALGLALRGIARAALDVSDGLLG DLGHILAQSQVGATVEVDRVPRSATLAEEPPARQLQCMLAGGDDYELCFTAPAGLREAVLAAGQHAGVPVTRIGR IDTEPGLRLIDAHGKPVAFSQAGFDHFSSTS Ralstonia solanacearum NYSGXRC-6109g SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC3362 MLEFDLIDRLRGRIRPRQDVLLGVGDDAALLQPPQGEPLVVTTDTLNAGVHFPVETHPEDLGWKTLAVSVSDLAAM GATPRWCTLSLSLLQADMAWIDAFADGFFELADLHGLVLVGGDTTYGPLATSVTAIGCVPPGMALRRDGACIGDD IWVTGRPGEAAAALAMWCAGMLDITKCAPDPRCEILRQRLLRPTPRVEVGLGLRGLVHAAVDLSDGLLADLGHIC ASSGVGAVLECASLPRVAVHGGWDEAQVASWQLAGGDDYELCFTAAPQCGAPIQDMCANLGVEVTRIGRIVVGET VQVLNAAGVPWQLSRKGYQHFMD Xylella fastidiosa NYSGXRC-6109h SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC3362 MAPSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAAVLPSRPGYDLVITKDA MVAGVHFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGWPSGSDVASRETFARGLAEDGALFDISLLGGD TVTTSGPLVVSATFLGWAPQGETILRRGAKPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTL RDAMRVHAKAAADVSDGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVCA VDPNEAWAFRVAAAAAGVKVSEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG Caulobacter crescentus NYSGXRC-6109i SGX Pharmaceuticals 2004-06-02 active Selected Cloned Expressed Soluble Purified EC3362 GENBANK NP_439456.1 MARVFNACLFFYKIGGKMAMGEFDLIKRYFQQQILVDDSVQLSIGDDCALVSVPENYQLAITTDTMVENTHFLPTI SPEDLAYKAVATNLSDLAAMGAQPKWVSLALTLPNVDENWISTFSQSLLHTLKQYNVTLIGGDTTKGNLSITITA QGFVEKNKGICRHKAQIGDLIYVSSTLGDSAAGLTQILLGKSAVDSDDVFLQQRHLRPTPRIELGQALIGIAHVA IDLSDGLISDLGHILERSQCSAEVELTALPLSSSILNKYDRTQAEQFALSGGEDYELCFTIPPEYKDELELRLKK LNVPCTCIGKINEKCGDFSPRFLRDGKPVNITFSSGFDHFKESK Haemophilus influenzae NYSGXRC-6109j SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC3362 VWMNGFARWMDKLKVLSSEAGSKACWGYDACPAGDGIIASIDGYSMDSSRLPWMSLGDWGWKSVVAAASDVAASGG APFHVMYSLGLDSVERAVDVARGVGEAAVWMGATVGKSDFNTSKSPWIDVAVLGKAEKPLGRFGAKPGMTLVQVG ASGYGLLSHLTLQGRLSRDDLPGPVVEYTRRPKPPLRIGPELSSCEAAASIDNSDGLGASLHLLGVESGVSVVID DILVDRHVEKVLDELGLEKWAVLQSWEDYNIVAVGGDGSIDCILRWCRRLNIECATVGYTSSDGAGRVLIEGGRR EFRVSGWTWL Aeropyrum pernix NYSGXRC-6109k SGX Pharmaceuticals 2004-03-26 active Selected Cloned Expressed Soluble Purified EC3362 MQRFNQRVWMMFGEFNLIDKYFSNRQAQRKDVHLALGDDCAIVKVPENSRVAISTDTLVAGTHFLAQANPAWVAHK ALASNISDLAAMGATPAWVSLALTLPEIDDAWLTPFCDAFFELAKYYNVQLIGGDTTKGPLSITLTVQGFLPKEQ AMLRSGAKVGDWLYVTGDLGDSQAGLDVILDPEKRHLPFADILEQRHYLSTPRIVAGQALVHLASSAIDISDGLI ADLQHILRRSNVGASIDVSLLPLSKELLQFVDSVTSAQQYALTSGEEYELCFTIPEENRGSLENALAHCGTKVTC IGQIRPAGTFELHNQGKKLDWQLAGYDHFKVKA Vibrio cholerae NYSGXRC-6109l SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble EC3362 GENBANK NP_069567.1 VFYANMKEFELIKLVERLFGDEDVITPAGKHDAAYVKIGNRLIVLTCDTVNEKSDFPPYMLPEEMGWMAIAVTLSD VAACGARPLYFLSSISLKSIEFFEDILLGIKRCADRFGVKVVGGDIDFSEITTIAGFAIGEARRHITRRGAKVGE GVFITDLPGKAQLCLEMLERGAKREELPYAEKLYTPVPRIEEGMRIARYASAMTDVSDSLAVSLHQISQSSNVKI VLDNIVLSHLSPAENALELFLYGGGDFELVYTAKSSDDGIRIGRVERGKGVFAEIDGKTFEVEFRGYSHF Archaeoglobus fulgidus NYSGXRC-6109m SGX Pharmaceuticals 2004-01-26 active Selected EC3362 MTKVKDIGEQGLLKILQRFCPPEIIGDDAAVLVTEPKQSLVVTTDILVDGVHFSDVTTSPEDAGWRAAAANLSDLA AMGATPLGITIALALPGDLSVSWVERLYQGITECLQKYHTPIVGGDVVRSPITTLSITAFGQVHPNRIIRRSTAQ VGDAIAITGVHGASHAGLELLLDPKIGKDLTPEEKVALIKSHQRPQPRLDVLPYLWQISHSPLPIAGMDSSDGLA DAVLQICRTSGVGAVIESDQIPLPAAFDHWLTPEQALNYALYGGEDFELVLCLPPDLATTLVQHLGQSAAIIGTI TSDTNVILHHRNTKIPDQVLTLSQGFQHFGH Nostoc sp. NYSGXRC-6109o SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC3362 ICEDB: T1703 GENBANK NP_273434.1 MKEFDFIKRYLQTGTDNDVVLGIGDDAAIVRPREGFDLCFSADMLLKDRHFFADVKPEDLAWKVLAVNISDMAAMG AIPRWVLLSAALPELDEVWLKRFCGSFFGLAKKFGVTLIGGDTTKGDMAFNVTIIGELPKGRALRRDAAVAGDDI WVSGRIGMAAAALNCRLKRCVLPDEVFAECEQKLLHPEPRVGLGLALLPFARAAQDVSDGLAQDLGHILTASGKG AEIWADSLPSLSVLKDILPRAQWLSYTLAGGDDYELVFTAPESCRSRVFDAAERCGVPVTRIGKINGGCRLKVLD ADGRELELHSLGFDHFG Neisseria meningitidis NYSGXRC-6109p SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC3362 ICEDB: T1708 MKETEIIKLFQEELKSKVLGDDAGFIKLGDRWLLLTNDMLVWRTDVPDFMTPEEAGAKVVTMNVSDIAAMGGKPIG FFFSLGLPRDINEKTLREIAKGIKRGTKRYNVEVLSGDTNESNELVIDGGAIGEAERILLRSGAKPGEVVCVTGD LGRPLTALLLWLKGEKIPREIAEKMKNPIARVREGLELANYASSAIDISDGLSKELWEISKASKVKIVIDPNSLP VHEKVKEIVKNPVEVALASGEEFELVFTISQEYLDILSFEFSIIGRVEKGEGVYTTTGEKVPMRGWEHFAGGNND IGS Pyrococcus furiosus NYSGXRC-6110a SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC4925 ICEDB: T1713 MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANL QHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAI ASCINAHPYVKGELCVSDDLTYTTGYFAAAKIGYHRLFDIKPVNTRYGGRIIFVDDCIDLNHYISFLESTPKQVV YETV Staphylococcus aureus NYSGXRC-6111a SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC3894 MVVRRKVHVLLIARSFHSYTPCFRVTTRGKRQRSKSKQQAKVELDHTRELDNDQATETVVDRSVGPEKDIESINKD FLQRTKGLEPDIELKQLPQIKQEFNQRYKDRYVKPSEDWYVNSWRSLTKPKIPLYKLINSDFQLITKLKAPNPME FQPVQLMESPLNVGDFVLLKMRPNELAMCVSLPSSTMDPRYTFVTIDGTMCFATKNRVLLRIPHKLPAGIRSLIQ PESHHKHLPIGTVKNFSNQTNILPIVARQLITSRYPAQISKLAWKDLPITTKKLQLLHRSLQNYMGPWQIPFFTL VGLVQKLDLNKALDDKNGINYLTSLVNNYHTVNDIPINSPTFVSTYWAIMQQQESNLWGEIHLNTALLSPISVTI IPLKSQHLYYAQVIEKLEANSYREVNKFVKLVNERKYRDISALYPSVIQLLKDFAAGNFHNNGIIVALISKIFRK IERYKDCDITRDICQDLINEITPNSIPNPLLLNMDLALPASSKLVKWQQKLYDLTNIEELQWKKSGTDDDRYDFG DLRVFCIDSETAHEIDDGVSVKNYGRDGLYTLYIHIADPTSMFPESTNVDIEGISTDILNVALKRSFTTYLPDTV VPMLPQSICHLSDLGKQGQRTKTISFSVDVKITSKCSGKSIEIMYDSFKIRKGIVSNFPKATYEDVDRILGTPNS EASPVKKDLESLSMISKLLREQRIKNSNAVIFGEGFNKGLVMLNADSEGELTEVTFSDQEETLSTILVSEMMILA NTLTGRYFAENKIGGVFRCYKQLPLGEVAQQQYDSMITSTKKGIFPKLKDIVKLSSLLNSSFYTGRPFRHEMIGA KQYLTVTSPLRRFPDLINHLQIHRHLQKKPLCFNQTQIDSLIWPIQSRADILKRASRNSSTYWTLNYLKKLTKLE PERTFDVMVTSVPQNGFTGCVFPDLSFARGTLKLHPSSMHYPMIGDIVKNCKISKIDCLEGMLELEKL Saccharomyces cerevisiae NYSGXRC-6111b SGX Pharmaceuticals 2004-01-26 active Selected EC3894 MNYRQLFLLQNVNLESNYLLKRVCLSLKLSPCKLTRKFHHACPSSSKVLKYFRITGCLINFGKQPANDHHLWGHCG ARLKHTQSDLIDRFKNANLKSVNEENLKKFFSELENHGNIRQWLKDKFEKDKRAAVCPTTTKSEEEKLENDFEYS FDLEDFSSENFRQYDRGDLLVFYRGSEGIELAACTGTNVWNYSNVLTSINENGTIKEFRTSRVLLRCPNVFKKLK EVQQPLSDVSVPSDVLPFTIKLLKKISQRAQDLSRSHRNEFLRILTEFNIPNKLDNSASFSDLLKFVYKTSKPSP YAKISLLHFLLTESKHFLISDHIFSEIQKVYFLPSSQNDSFDDVVACLRQKSTPYLSFIKKARHLIQVSRDKYKL PISTEEIKPVVYSQVTWTEFEKKLLRYLVQEMIAKSIQSLPNTHLCQVYKEVGLQTHERGLTSDQFAKFLTDIGV WASWQPPRLFQQEYSIAGLGTNPQLDAVYERECNHFKKFVKNELKDSLESQRVDLRHLKAFAFDSSSTKEIDDAI SVEELGMSNSWLHIHVANPTSTVDIRSPLGTFAERNFQTIYHPNKIVYMLPLNITQKYWSLDSSSTAQRALTFSA KISKNGDILDYKVRPSFISSVIKYTPQQLDKALHSNRSIAKDIVSGPVDEETKGVSNDHMKDILRIYELS Schizosaccharomyces pombe NYSGXRC-6112a SGX Pharmaceuticals 2004-01-26 active Selected EC2728 MGHSVAGVCLEEPAVLTAFPSLLHPQDPPQQRDRILFVTAELSDFVKVGGLGDFSAALPRVLKREHSVRVLLPGYR QVLERCRDLRIIGSLPGRAAIPPCEIGLVTLDDGLEVMLVLCPLLYEREGTPYMDDQGNDWPDNHLRFARLCLAA AEIAGGRGAQGWQPGLVHANDWPSALTPAYMAWNGVRTPSLFTIHNLAYQGLCDLQCSAELGLPDEALSHESMEF HGRLSFLKAGIAHAHHITTVSETYAQEITTPEYGCGLHGILKYKVEKRQLSGIVNGIDDSWQPHCDPHLVACFSA RQWAGKRANTRYVEERFGLEPGKGPLFAVVSRLVQQKGIDLTLEISDALLQAGGRLVSIGRGEPNLEKAMLELAR RHPGQVGVHIGFDETEARRIYAGSDFLLMPSRYEPCGLSQLYAQCFGSLPIARCTGGLADTIVDGVTGFLFREET AQSYLDAVMRAINVYHCPSLLNAMRCKAMAAPMFWSDSVEPYNRLYRRLLRNTAPALRGVRQ Pseudomonas aeruginosa NYSGXRC-6113a SGX Pharmaceuticals 2004-11-28 active Selected Cloned Expressed Soluble EC3535 GENBANK NP_289144.1 TEKKCTVMLSKFKRNKHQQHLAQLPKISQSVDDVDFFYAPADFRETLLEKIASAKQRICIVALYLEQDDGGKGILN ALYEAKRQRPELDVRVLVDWHRAQRGRIGAAASNTNADWYCRMAQENPGVDVPVYGVPINTREALGVLHFKGFII DDSVLYSGASLNDVYLHQHDKYRYDRYHLIRNRKMSDIMFEWVTQNIMNGRGVNRLDDVNRPKSPEIKNDIRLFR QELRDAAYHFQGDADNDQLSVTPLVGLGKSSLLNKTIFHLMPCAEQKLTICTPYFNLPAILVRNIIQLLREGKKV EIIVGDKTANDFYIPEDEPFKIIGALPYLYEINLRRFLSRLQYYVNTDQLVVRLWKDDDNTYHLKGMWVDDKWML ITGNNLNPRAWRLDLENAILIHDPQLELAPQREKELELIREHTTIVKHYRDLQSIADYPVKVRKLIRRLRRIRID RLISRIL Escherichia coli NYSGXRC-6113b SGX Pharmaceuticals 2004-03-03 active Selected Cloned Expressed Soluble Purified EC3535 ICEDB: T1695 GENBANK NP_438586.1 MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKDEAGQEILDEIYRVKQE NPHLDVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDDPNMFFGVPINTREVFGVLHVKGFVFDDTVLY SGASINNVYLHQFEKYRYDRYQKITHAELADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQN GEYSLKSAVKLPNVLSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEII VGDKVANDFYIPPEQPFKMAGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTYHLKGVWVDDRYILLTG NNLNPRAWRLDAENGLLIYDPQQQLLAQVEKEQNQIRQHTKVLKHYTELEELNQYPEPVQKLLKKFARIKADKLV KMIL Haemophilus influenzae NYSGXRC-6113c SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC3535 MKLALLMLLAAALIEVYPNPYGLDDAEYVKFRCNSSCLLTDGEGWVEAGPGTHIAAKNLSYFEERFGYRADVQFSP QMALSNSGEEVCVEDAEGKDCFYYGKDIKFLDDGVIYYRTASGWDFRYEDWSNFSCLTEVVEGQLILTPSDFTLD DGWVVASYTFHAPFSPSKLFVDARTDRPCREFETDTVFLSAPSYRNFHYKFAVKGDKVVITTENWQFSKRGFVVL FENHNVSEMLQNLLRNDEKYRTSVSKTCSNWTYRNGADGRTLTFKAPITVFILPDCNPVLKFISSARERLLIIAP YIDFRWYKDDGLLEAIKGAKESGAEVKVVLNAKYAKEEAVSTLRKEGVKVELIDNLHGKAIVSDKRLLITSANMN MHGLKLNREIGVIINNPEMADAVIKEFEGGEVTPLDLLLTFAAFLASVAIFRKMKDKF Archaeoglobus fulgidus NYSGXRC-6113d SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC3535 ICEDB: T1716 MLSKFKRNKHQQHLAQLPKISQSVDDVDFFYTPATFRETLLEKIASATQRICIVALYLEQDDGGKGILDALYAAKR QRPELDVRVLVDWHRAQRGRIGAAASNTNADWYCRLAQENPGIDVPVYGVPINTREALGVLHFKGFIIDDSVLYS GASLNDVYLHQHDKYRYDRYQLIRNRQMADIMFDWVTQNLMNGRGVNRLDNTQRPKSPEIKNDIRLYRQELRDAS YHFQGDANDEQLSVTPLVGLGKSSLLNKTIFHLMPCAEHKLTICTPYFNLPAVLVRNIIQLLRDGKKVEIIVGDK TANDFYIPEDEPFKIIGALPYLYEINLRRFLSRLQYYVNTDQLVVRLWKDDDNTYHLKGMWVDDKWMLLTGNNLN PRAWRLDLENAILIHDPKQELAPQREKELELIRTHTTIVKHYRDLQSIADYPIKVRKLIRRLRRIRIDRLISRIL Salmonella typhi NYSGXRC-6113e SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC3535 GENBANK NP_229969.1 MIARRNPIEQLPAIAQDPDKFGVLLSAAEFRTHLVESIRQARKRIYLVALYLENDDAGREILTELYAAKQRNPGLE IHICVDWHRAQRGLIGAAESEGNAAMYRDFAQQHEHCIPVYGIPVRGREVFGVLHLKGFIIDDQVIYSGASLNNV YLQFHGRYRFDRYHTLENAELADSMVHFIQQEMLAHPAVNNLACGSKPTTKEIKSDIRQFRASLAQANYQFAKQK VNEGQVAVTPLVGLGRRRNRLNQSIIQLLASAKDEVFICTPYFNFPPSIAKEVKKALRRGVKVHIVIGDKTANDF YIAPEEPFKTIGGLPYLYELNLRRFAKANEAHIASRKLSIHLWKHENHSFHLKGIWVDKRYMLITGNNLNPRAWK LDLENAILIRDDYHHLTTKFEAEIDNILQHTQLICTYKQIEKPEHYPEKVQRLVRRIMRLKADRVLKQIL Vibrio cholerae NYSGXRC-6114a SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble EC4793 GENBANK NP_249984.1 MKKLSGIIVLLLAGAALYLALKTSPIDPLAWDAPAAPQMTGVLEPNDTLMKAELLGQGQLHGPEDTAVDSQGRVYA GLADGRVVRLDASGKVETFVDTGGRPLGMDFDAAGNLILADAWKGLLRIDPQGKVETLATEADSVPFAFTDDLDI ASDGRIYFSDASSKFHQPDYILDLLEARPHGRLLRYDPSTGKTEVLLKDLYFANGVALSANEDFVLVNETYRYRI TRYWLKGEKAGQHEVFIDNLPGLPDNLQGDRKGTFWVALPTPRKADADFLHRHPWLKAQLAKLPRMFLPKPTAYG LVIAIDEQGRIVRSLHDTSGHHLRMITSAKPVGDQLYFGSLENDRIGRLAIP Pseudomonas aeruginosa NYSGXRC-6114b SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC4793 MTPASAVPAHPCPPGPNALRRRLLQAALSTGVLASIGTAAPAAASAHATSTPSKPMDLYAYVGSRTTRERNARGDG ISVFRVDTQTGGLAPVQLVKDLVNPSFLALNPAGDRLYTVHGDLADISAFAVDRASGRLSFINRQSTQGKNPVHL ALDPSGRFVVVTNHIGASLAVLPLAADGALGEVTQLVKLDGPIGPHRIEQKQAKPHFNRFDPAGRFVIVPDKGLD RTFAFRFAEGRLTPATPSFVSAREGAGPRHVAFRPDGRVAYVVNELDSTVTTYGYDAGTATLTPLQVLPSLPDTF TGNSRASEIKVDAAGRFVYASNRGHDSIAVFRIDAASGLLRFVAAEPSLGRTPRFFTIAPGGRFLYALNEDSDSI VAFAIDPHTGRLHPTGTRAQSGSPVCMVFSTPAA Ralstonia solanacearum NYSGXRC-6114c SGX Pharmaceuticals 2004-03-16 active Selected Cloned Expressed Soluble Purified EC4793 ICEDB: T1688 GENBANK BAA21591.1 MYKRMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGAVIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLG KTYTQSPVLGTNGVIYLASYDKKIYFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKST WTERWKLKTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGNIYAGNQDGQL YAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGDMNWSFYTDGPVRTAPLIDAKGTVYFGS DDMKVYAADANGNELWSYQTDSNVVSSPQLAEDGTLYIGSYTKLMAFGK Bacillus subtilis NYSGXRC-6114d SGX Pharmaceuticals 2004-04-02 active Selected EC4793 MRHLPYPLLGLFLALSSTGAALAGEQYYPLDKGSAPYAVAPSAQGAVWYGADGGHSLGRLDPTSGESVQVPLGEGA RPRAIVSDESGNAWVLDSGLNAILRIGGERLGSERFPLPAKAAPAGLESAVFDDDGRLWFTGSRGFHGRLDPARR LVEVWPSPQGKAANGICVTPDGEVWYAQDDALVHVDPLDGSAERLPAPEGTKALRGIGADSIGRLWASDSGGARL YRYDPSDASWQSWPLPDSQARPDSLRVDAMDRVWLHDAASGALLRFDSEQATFRVLPSDRPAPGNALLGGRPGET WSAEPAADRLRVVRD Pseudomonas aeruginosa NYSGXRC-6115a SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC4749 ICEDB: T1699 GENBANK NP_208016 MREIVWVHSQRIAPYKTLILNELHYYPLESDLTPFNALIFTSKNAVFSLLETLNNSPKLKMLQNIPAYALSEPTAK TLQDHHFKTAFIGKKAHGKEFAKEILPLLEKKSVLYLRAKEIASSLDTILLEHGINLQQAVVYENKLKHLTLSEQ NALKPQEKSVLIFTAISHAKAFLHYFEFLKSYTAISIGNTTAHYLQEQGIQSYTAQKPSLESCLELALNLKS Helicobacter pylori NYSGXRC-6115b SGX Pharmaceuticals 2004-05-24 active Selected Cloned Expressed Soluble EC4749 GENBANK NP_282228.1 MKIYLLNETPFEGVENLILNEIVFYDFSVDLSLYDALICTSKNALKALQHAKITLNFKLNLYAVGQSTAQYAKNLG FKKIKIPSKAYGKDLFLEFKEELKMQKCLYLRAKNIVSTLNLDLKNVGVDLDEMIVYENVFKKGDKKLIHPAIFI FTSPLSVENFLKFYSLKEEDKVVVIGQSTAKKLLNFKNLYICENQSLLNCVKLAKTLV Campylobacter jejuni NYSGXRC-6116a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC1925 GENBANK NP_207735.1 MKKEVVVIGGGIVGLSCAYSMHKLGHKVCVIEKNDGANGTSFGNAGLISAFKKAPLSCPGVVLDTLKLMLKNQAPL KFHFGLNLKLYQWILKFVKSANAKSTHRTMALFERYGWLSIDMYHQMLKDGMDFWYKEDGLLMIYTLEESFEKKL KTCDNSGAYKILSAKETKEYMPVVNDNICGSVLLTENAHVDPGEVMHSLQEYLQNVGVEFLYNEEVIDFEFKNNL IEGVITHKEKIQAETIILATGANPTLIKKTKNDFLMMGAKGYSITFKMPEELKPKTSSLFADIFMAMTPRRDTVR ITSKLELNTNNALIDKEQIANMKKNLAAFTQPFEMKDAIEWCGFRPLTPNDIPYLGYDKRYKNLIHATGLGWLGI TFGPAIGKIIANLSQDGANEKNADIMLFSAFFRD Helicobacter pylori NYSGXRC-6116b SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified EC1925 ICEDB: T2193 GENBANK NP_230435.1 MMEVLVLGSGVVGLTSAWYLAQAGHDVTVVDRQPRGAEETSFANAGQISYGYSSPWAAPGIPQKALKWMLEKHAPL KIQPSLDPALLSWMGKMLLNCQLSRYQVNKSRMLAIANYSRECLKALNQTYSLDYQGRQRGTLQVFRDEKQLTAI EKDMQLLAQSGVRFELLNVAQCLTHEPGLAPVQEKLVGGLWLPDDETGDCYLFCQQLTELAKQQGVRFHFDCHIQ QLVCEGKKIIGVQTDLGLLKADAYVVALGSYSTSLLKPLGIEIPVYPVKGYSLTLPIIDEKFAPQSTVMDETYKV ALTRFSDRIRVAGTAELAGFDPAIPEARKATIEMVARDLFPHGGDFAKGQFWTGFRPMTPDGTPIIGATPYTNLY TNTGHGTLGWTMACGSASILADVLTHGESPLSRLGLDLFRYPKAS Vibrio cholerae NYSGXRC-6117a SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble Purified EC4297 ICEDB: T1859, T83 GENBANK NP_370800.1 MEDVLYMKKLTAAAIATMGFATFTMAHQADSAETTNTQQAHTQMSTQSQDVSYGTYYTIDSNGDYHHTPDGNWNQA MFDNKEYSYTFVDAQGHTHYFYNCYPKNANANGSGQTYVNPATAGDNNDYTASQSQQHINQYGYQSNVGPDASYY SHSNNNQAYNSHDGNGKVNYPNGTSNQNGGSASKATRSGHAKDASWLTSRKQLQPYGQYHGGGAHYGVDYAMPEN SPVYSLTDGTVVQAGWSNYGGGNQVTIKEANSNNYQWYMHNNRLTVSAGDKVKAGDQIAYSGSTGNSTAPHVHFQ RMSGGIGNQYAVDPTSYLQSR Staphylococcus aureus NYSGXRC-6117b SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC4297 GENBANK NP_294572.1 MKARFLLLAALLSGVAGAYTVKKGDTLYSLARGSGLTVDALMRLNGLSTPELRVGQVIKLPGEGAATPATPAPAAP TPATPAPAAPAPAPAVPTKLPTVATAANVLKLPGVTITAPKALKMGDGFALRLSGEQAANVTVRFPSELGEDVRQ PNEELRPLWSSGQYIVPGRVVLGKTTPVIYEVRLGGDVVRGQIPVGDLGQRVQHLNLPPSISKVLQDPAREAEDA AVEQAYQRRTPQQWQQPFASALASGKATSSSFGQPRTYVAGGKVAYHYGTDYPARSGTAVLAINDGTVVIAGRYP VRGGLVVIDHGAGVVSLYFHQSKVTAKVGQQIKRGQKVGEVGSTGLSAGPHLHLEVRVRGEGTNPAGWMGKLWP Deinococcus radiodurans NYSGXRC-6117c SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC4297 MSAGSPKFTVSRIAALSLVSLWLAGCTSSSNPPAPVTSVDSGSSSNTNSGMLITPPPKMGATTQQTPQQAPQIQPV QRPVTQPMQTQPVTEQPVQMENGRIVYNRQYGNIPKGSYTGGSTYTVKKGDTLFYIAWITGNDFRDLAQRNSISA PYSLNVGQTLQVGNASGTPITGGNAITQADAAQQGVVTRSAQNSTVAVASQPTITYSEGSGEQSANKMLPNNKPA GTVVTAPVTAPTVSTTEPNASSTSTSAPISAWRWPTDGKVIENFGASEGGNKGIDIAGSKGQAIVATADGRVVYA GNALRGYGNLIIIKHNDDYLSAYAHNDTMLVREQQEVKAGQKIATMGSTGTSSTRLHFEIRYKGKSVNPLRYLPQ R Salmonella typhimurium NYSGXRC-6117d SGX Pharmaceuticals 2004-04-02 active Selected EC4297 MRQLWTQAAVIALTAGTLGAPAHASGQSGQRFTPNFPITQPAAPPPGETIQAQPGEAESLPRPTPIPVQSAPPIAQ AELPPPAPVSTPAPAPQPVLRATPPRTVVTTTVTGPVVEVAGKPQVRVVESGDALDAIARGMGSTRAELVKLNDL EPPYRLKLGQKIKGPATTAKAYVVQTGDTMFAIAKRFNVTAAALAEENDLKSGAAIKKGQKLLLPDGYKDKGPIK TTQVIPGTPATMVAEAEPAPATTRPATPAATPSRPVRQPVSEETSEPATTSTTTLSVTGSVVTVAGPRQVHTVKS GDTLTAIARKFDMSVSELAEANKLDTEKPLKLGAKIKGPATTQKAYSVQTGDTLGEIAKRFNVSVKALAAENNLR ATASLKKGQKIALPDGFRDKGPIRTTTTTRPATPPANTYARVDSSAAAASTPSSPVPYTPSGAAPRPSAPVAAQP ITPPPSSGRTIIETAAAPTEAEIIASGKGKFAWPLRGDIISSFGVKGTGQRNDGLNIRAPQGTPVLSSADGEIAY AGNQVPTFGNLVLVKHADGWVTAYAHLSSTNVKMRQQVKQGEQLGTVGATGGVNEPQLHFEMRYAPTVKDKAKPV DPALVLPR Caulobacter crescentus NYSGXRC-6117e SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC4297 MQIILIHPRKAGAVHLSRRQFAVAMGAALLAVAALSGGATWLAVKRGLVPGATAAASTEADKRITRENLNLMAARI GEMQAQMVRLDALGARVSGLAGVPPREFDFKSMPGRGGPQGAVSRSLSMPEIQSELDRLTRSADQRNDYLSVLES TLMDRQIHAKMMPTVRPVATGYDSSGFGVRIDPFTGRRTQHDGVDFVGPVGTPIVAAAGGVVVASEYHHEYGNMI DIDHGNGLKTRYAHASKVFVKVGDIVKAGQRIALIGRTGRATGPHLHFEVHVNDVPQNPVAFLENAGQPKMAVDK DAGPQMAAADIGKSLAAAGR Ralstonia solanacearum NYSGXRC-6117f SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble Purified EC4297 GENBANK NP_438864.1 MKKSFLLLPLSLVVLSACTSNFPAPISDADGNFSPSVIQSVNGSNVGGAWQPEIQKNSLPTTGNMVTPQQNFQPIN QQPTMPTAPAQPAFQPSPKTVVSAPTVQTKTVTKTVADCVDGQHINIPRNPNTNAPDYSKISKGSYKGNTYKVNK GDTMFLIAYLAGIDVKELAALNNLSEPYNLSLGQVLKISNCDIKTVTTTVSVKQPAVTASTATPVKPAVTYTPGA NGTQIGSDGTIIGPIKSEAGTSPSVPVATSSTQVTSSVNNANSTPINSNVVAPIASNVVWQWPTSGNIIQGFSST DGGNKGIDISGSRGQAVKAAAAGRIVYAGNALRGYGNLIIIKHNDDFLSAYAHNDKILVADQQEVKAGQDIAKMG SSGTNTVKLHFEIRYKGKSVDPVRYLPRH Haemophilus influenzae NYSGXRC-6117g SGX Pharmaceuticals 2004-01-26 active Selected EC4297 VKAVLKNTPTRDDAPADQFNVVNNQANRRARRQAAMIGLAISMGATSLLVTRQSDQAQAAAPVGSQKAASSIPTAT DSELKLAATQLGTSRVLATSVPENPVIMEPTAVSQLPGLEAKWQILSSGMSVQLPASENITKNIAFHKTTINHQS QLAQGEQTTKPVKEIAAQLNNVNGVTAGQNTLPTTQPQALADDTTASDGINAQLKAQQEFALSRLQEKSSRLRKS LAELRSEESKDLSKATIGLTQPTSLANQLPPLTTNGTVIEQQLTVANGSQDSLATTIKQPQPINIQVQPLTETSA STANTYEVKPGDTLAAIASRYNTSVAELVKVNNLSNPNQLKISQQLIIPSAIDSSSTIAQAPAIISSNRVQYPGT PTVPNFPVDTARVNPSLPVAQPPSIANNDSVPITVPTPGADSETPVDTIVPLESASAPAETQGVGGNVPIPKAFI EIQRPQQPGKRAARAKGDRLRSLQAEIQRLQAKYRDQQTGNTPVPVVANQNNNTAIPIPVTSPNNFAVTRPISRQ QEIAVPIAVPTPLAPNDSNHPVKPQFRATLPVNEALNPEFLPNNAPQNPSVRRVATPPVRLNASESLGRMRGTTV SPKLPPLAAVDQYLPQAIDESVPPPSDSTTAFIWPAKGVLTSGYGWRWGRMHRGIDIAAPVGTPVFAAADGVVEK SGWNRGGYGNLVDIRHPDGSLTRYAHNSRLLVQAGQQVRQGQQIAAMGSTGFSTGPHTHFEIHKTGKGAINPIAM LPATTSNRI Nostoc sp. NYSGXRC-6118a SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC919 MSSNSTPEKVTAEHVLWYIPNKIGYVRVITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVL DMVTDRSSTAGLMCFLCVQYPQWCVFFQLMLGLDITSHYMHMYASLSAGKTSHKSVGEGESRLLHLYYTRRDVLF TICAFNELFYAGLYLQLFSNSATFGKWTTIISFPGYVFKQTANVVQLKRAALILADNDAKNANEKNKTY Saccharomyces cerevisiae NYSGXRC-6119a SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC432 GENBANK NP_390074.1 LPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLMPKKIQTETQLLRLLGNSPLQVHFTFLIPSTHT PKNTAREHLDEFYTTFSNIRHKRFDGMIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYY HYGVEKIQMPKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAGGLLNCV Bacillus subtilis NYSGXRC-6119b SGX Pharmaceuticals 2004-03-02 active Selected Cloned Expressed Soluble Purified EC432 ICEDB: T1684 GENBANK NP_243146.1 MPIKIPDNLPAKEILTKENIFVMAESRAYSQDIRPLKIVILNLMPIKQTTETQLLRLLGNTPLQVEVSFMYTDTHI SKNTSYDHLQTFYQTIDEVKQKKFDGMIITGAPIETLPYDEVDYWNELKQIMEWSKTNVTSTLHICWGAQAGLFY HYGVEKVPLPEKQFGVYPHKINVPNVKLLRGFDDEFYVPHSRHTDINKAQIEAHPDLEILSESEQAGVYIVASKD GKQIFVTGHSEYDACTLQQEYERDRARGLNIQVPENYFPNDDATRKPLLRWRAHSYLLFSNWLNYYVYQETPYDL SR Bacillus halodurans NYSGXRC-6119c SGX Pharmaceuticals 2004-03-23 active Selected Cloned Expressed Soluble Purified EC432 ICEDB: T1735 GENBANK NP_348450.1 MPIKIPDNLPAAKTLNEENIFFMDEDRAYHQDIRPLNIVIVNLMPTKIVTETQILRLIGNSPLQVNPTFIHTQTHK SQNTSKEHLIKFYETFEEIKNNKFDGMIVTGAPVETLSFENVDYWEELCRIFDWSVTNVTSTIHICWGAQAGLYH HYGIPKYELHEKLFGVFKHNLTERNIKLTRGFDDEFYAPHSRHTYVKREDIKKNPSLKILAESDEAGAYIVASEN GKNIFVMGHAEYDGDTLNLEYIRDKNQGMNIKIPKNYFKDNDPEKGPMVTWRGHANLLFSNWLNYYVYQETPFEL Clostridium acetobutylicum NYSGXRC-6119d SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC432 ICEDB: T1719 MPITLDKKLPAVDILKSENIFVMDDKRAIHQDIRPMSILILNLMPTKVATETQLLRLLANTPLQLSVDFLYMTSHH SKTTQAEHMKTFYKTFKDIKDNYYDGLIITGAPVETMPFEKVDYWEELCQVFQWSKTHVYSTLHLCWGAQAGLYY RYSVDKVQMTDKLSGIYLQKVNEQLSPLMRGFDDCFLSPHSRYTEVLLKDINNKTNLEILASGEKVGLSILASRD MREVYSFGHLEYDRETLDNEYKRDLKAGKSPKIPENYYQDDDVTTHPIMRWNLAAATFFSNWINYAVYQETPYRL EELEKDISFYGYL Streptococcus mutans NYSGXRC-6119e SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC432 ICEDB: T1723 MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLANTPLQLDIDFLYMESHR SKTTRSEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYL RYGVEKYQMDSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRD LREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFDW RKIEDDASAYGYL Streptococcus pneumoniae NYSGXRC-6119f SGX Pharmaceuticals 2004-03-17 active Selected Cloned Expressed Soluble Purified EC432 MLREKAVPIRIPDQLPASDVLRNENIFVMSESRASTQEIRPLKVLLLNLMPKKIETETQFLRLLSNSPLQVDIELL RIDDRPSKNTPEEHLNTFYRQFELVKNRNFDGLIITGAPLGLVQFEDVAYWQHLQNIMAWAKAHVTSTLYICWAA QAGLKLLYNLPKRTREEKLSGVYYHDIHKPFHPLLRGFDDRFLAPHSRYADFDAEFLAEHTDLDILATSDVAGVY LAATKDKRNVFVTGHPEYDAYTLHGEYVRDLGEGLNPAIPVNYYPNDNPDNKPCASWRSHGHLLFANWLNYCVYQ QTPYDLEKFSEANFTKDE Vibrio cholerae NYSGXRC-6120b SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC3446 ICEDB: T1704 GENBANK NP_273664.1 MIQAVLFDLDGTLADTALDLGGALNTLLARHGLPAKSMDEIRTQASHGAAGLIKLGAGITPDHPDYARWRTEYLDE YDSRYAQDTTLFDGVNELIAELGKRGIKWGIITNKPMRFTDKLVPKLGFIIPPAVVVSGDTCGEPKPSVKPMLYA CGQIHADPQHTLYVGDAERDIQAGRNAGMTTVLAEWGYIAPEDDTGSWQADFHIRTPLDLLECLDKIQP Neisseria meningitidis NYSGXRC-6120d SGX Pharmaceuticals 2004-01-26 active Selected EC3446 MLTAILFDLDGTIVNTDPIHYQAWRQMLWKCNIEIDETFYKSRISGRLNPEIVKDILPELSSAAGREFADEKEALF RELASHLQPLNGFAELIAWTEVHQLKRALVTNAPRLNAEFMLEVLGITDSFHQIVLADDCVAGKPDPAPYQVALS KLGIPAEKAIALEDSPSGIRAAVGAGIRTIGIASTHDPDILLEVGSFMAIPDFTDLHLWTLLNSLIEPDLIRST Nostoc sp. NYSGXRC-6120e SGX Pharmaceuticals 2004-03-22 active Selected Cloned Expressed Soluble EC3446 GENBANK NP_213659.1 MLKDFLKEQGFEVRENHEVDAVIIGQDKEIEFKKIKNATSAVFLKGAKIIPVNLSKIVKDSDGLYFPGSGSYAYMF KHATNYEGEIPNLGKPSKEFINLALEGLPREKVFLISDDIYTDLMGAKELGIGTIFMTTGKYKQEELKKANFKPD YVFHSLKELMREIKKWLS Aquifex aeolicus NYSGXRC-6121a SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC1550 MKYVVVSGGVISGIGKGVLASSTGMLMKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYER YLGVTLTKDHNITTGKIYSHVIAKERKGDYLGKTVQIVPHLTNAIQDWIERVAKIPVDDTGMEPDVCIIELGGTV GDIESAPFVEALRQFQFKVGKENFALIHVSLVPVIHGEQKTKPTQAAIKGLRSLGLVPDMIACRCSETLDKPTID KIAMFCHVGPEQVVNVHDVNSTYHVPLLLLEQKMIDYLHARLKLDEISLTEEEKQRGLELLSKWKATTGNFDESM ETVKIRLVGKYTNLKDSYLSVIKALEHSSMKCRRKLDIKWVEATDLEPEAQESNKTKFHEAWNMVSTADGILIPG GFGVRGTEGMVLAARWARENHIPFLGVCLGLQIATIEFTRSSLGRKDSHSAEFYPDIDEKNHVVVFMPEIDKETM GGSMRLGLRPTFFQNETEWSQIKKLYGDVSEVHERHRHRYEINPKMVDELENNGLIFVGKDDTGKRCEILELKNH PYYIATQYHPEYTSKVLDPSKPFLGLVAASAGILQDVIEGKYDLEAGENKFNF Saccharomyces cerevisiae NYSGXRC-6121b SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC1550 ICEDB: T1720 MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYE RFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAATTTDSDVIITEVGGTVGDIES LPFLEALRQMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEQPAGQGIKNKLA QFCDVAPEAVIESLDVDHLYQIPLNLQAQNMDQIVCDHLKLDVPVADMTEWSAMVDKVMNLKKKTKIALVGKYVE LPDAYLSVVEALKHSGYVNDTAIDLNWINANEVTPETVTDLLGDADGIIVPGGFGHRGTEGKIEAIRYARENDVP MLGICLGMQLTCVEYARHVLNLEGANSAELDPDTKYPVIDIMRDQIDIEDMGGTLRLGLYPCKLKSGSKTASAYS NQEVVQRRHRHRYEFNNAFRQQFEEAGFVFSGVSPDNRLVEVVELSDKKFFVAAQYHPELQSRPNRPEELYTAFI TAAVENSQAH Streptococcus mutans NYSGXRC-6121c SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble Purified EC1550 ICEDB: T2198 GENBANK ZP_01068758.1 MKQTKYIFVTGGVLSSLGKGIAAASIATLLKNSGLKVSILKADPYINVDPGTMSPFEHGEVFVTDDGAETDLDLGH YERFLDESLSQDNNFTTGRVYQSVIEKERRGEYLGKTIQVIPHIVGEIKDRIKKAGEGKDILIVEIGGTVGDIEG LPFLEAIRALRLEVGKNNAMNIHLTLVPFIKAAGELKTKPTQHSVGELRRIGISPDMIICRSEKALDRDLKDKIA ISCGVEKNCVIESVDAASIYQIPLNFLKQDILSPIAEILDLKNLKPNMENWDSLVKRVIAPSNEVKIAFVGKYVD LKESYKSLTEAIIHAGAALDTKVELKWVDSEKLENMESSEVFKDVSGILVAGGFGYRGVEGKIKAIQYARENKIP FLGICLGMQLALVEFARNVLKLKDVNSSEFNEKCQNPVVYLIDEFMDTNGEKQIRTAKTPLGGTMRLGAYKCDIK EKSLLAKVYNEVKSVKERHRHRYEANPKYRADFEKYGLIVSGESKGLIEAVELNCHPFFLAVQFHPEFTSRLEHV NPVICSFIKAAINYEDN Campylobacter jejuni NYSGXRC-6121d SGX Pharmaceuticals 2004-03-12 active Selected Cloned Expressed Soluble Purified EC1550 ICEDB: T1730 VTGGVISGLGKGTITSSIGHILKDSGIKVSAVKIDPYINYDAGTMNPYQHGEVFVLDDGGEVDLDLGNYERFMNIN LSRDNNITTGKVYLEVIQKERHGDYLGKTVQIIPHITDEIKRRIREVARTSGADVVLIEVGGTVGDIESMPFLEA LRQLKREEQNVVFAHVTLVPEIGPTMEQKTKPTQHSVKALREIGIQPDIIFARSKQKLTEETKSRISLFTDVPVE GIISVSDVENVYLLPQMMVNEGLITRLSKLLNMNIEYRDSWTSYAENIRHPRDRVKVAIVGKYVDLHDAYISHKE AFSHVTGNTGIAVDIMWIDSEKVKNDQSVLSEADAILIPGGFGYRGVEGKIAATRYAMENGVPFLGICLGFQVAV IAVARYVLGLDGANSTEFDEKTKYPVVDILPEQRGVKDMGGTMRLGSKKVVIKKGTLAHRIYGADVIYERHRHRY EVNPDYIDMIEKAGFKFSATDEEGIRMEILERPGDESFIATQYHSEFKSRPLDPSKVHLHLVEQALIFKHRRMGE NHEGYATAASSQGQ Thermoplasma acidophilum NYSGXRC-6121e SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble EC1550 GENBANK NP_420528.1 MTRYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYE RFTGVSATKADNITTGQIYKTIIEKERRGDYLGATVQVIPHVTNEIKDFVLSPAMDETGEKAVDFVLVEIGGTVG DIEGLPFFEAIRQLRQDLPRGQSCYVHLTLLPFIKTAGEMKTKPTQHSVKELRSIGIQPDILLCRCEQEIPPEEK RKIAQFCNVRPSAVIQAMDSSSIYAVPIDYHEQGLDAEVLDVFGMRDAPAPDLTRWKTIDDTVQHPDGEVTIAVV GKYTVLKDAYKSLIEALHHGGLANKVKVNLDWVESETFEGDEGAAAARLENAHAIMVPGGFGERGAEGKIRAAQF ARERKVPYFGICFGMQMAVIETLRNVAGIKDASSSEFGPTERPVVGIMTEWIKGNETVQRRANDDLGGTMRLGAY DAVLTAGSKIAEIYGATEISERHRHRYEVNIGYVHLMEDAGLKLTGRSPNGVLPEIVERDDHPWFIGVQYHPELK SRPFAPHPLFASFIAAAKEHGRLV Caulobacter crescentus NYSGXRC-6122b SGX Pharmaceuticals 2004-03-23 active Selected Cloned Expressed Soluble Purified EC4978 ICEDB: T1739 MQYIVVTGGVISGLGKGTITSSIGHILKDSGFKVSSVKIDPYINYDAGTMNPYQHGEVFVLDDGSEVDLDLGNYER FMDINLSWKNNITTGKVYLEVIEKERHGDYLGKTVQIIPHITDEIKRRIRDVATSSKADFVLIEVGGTVGDIESM PFLEAVRQLKREENNVIFAHVTLVPEIGPTEEQKTKPTQHSVKALREIGIQPDIIFARSKNRLLEETKKRISLFT DVPEGGIISVYDVENVYLLPEVMVNEGFISYLSKLSGKEIKYRDSWKAYTENIKHPKDRVKIAIVGKYVDLHDAY ISHKEAFSHVTGNTGIAVDIKWLDSEKVKDDQSMLSDVDAILIPGGFGYRGVEGKIAATRFALENHIPFLGICLG FQVAVIEIARDIIGLQNANSTEFDPATKYPVIDILPEQKGIKDLGGTMRLGSKKVLIKDGTLAKRIYGTDTIYER HRHRYEVNPNYISIIEKAGFVFSGTDEDGIRMEILEKKGDESFIATQYHSEFKSRPLNPSRVHLHLVQQALIYKK NKDIGEAVKLRSSV Thermoplasma volcanium NYSGXRC-6122c SGX Pharmaceuticals 2004-01-26 active Selected EC4978 MKYVLVSGGVISGIGKGVIASSTGLLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGEVFVLNDGGEVDLDLGNYER YLNVTLTHDNNITTGKVYSNVIQKERRGDYLGKTVQIVPHVTNEIQDWVERVARIPVDQSGEEPDVCIVELGGTV GDIESAAFVEAMRQFQFRVGHENFVSIHVSLVPVINGEQKTKPTQQAIRDLRSLGITPDLIACRCKQPLEKSVID KISLFCHVGPEQVLAVHDVSSTYHVPQLLEDKLLEYLKIRFALDKISVSRELALAGENMWSSWKHLTQGYDHLFK KVTIVLVGKYTHLQDSYISVIKALEHSAMRCGRKLDLQWVEASHLEASTNTSDPLSYHKAWHLVCSANGILVPGG FGSRGVEGMIAAAKWARENNTPYLGICLGMQVAVIEFARSVCGIEGAFSEEFDKECENNVVVYMPEIDKDKLGGT MRLGLRPTFFQPNSEWSKLRKLHKMVDEVLERHRHRYEINPAFVSRLEQGGISFIGKDERGERMEIIEKRDHPYF VGVQYHPEYLSKPLKPSPPIFGLVAASAGLLDEFIQSGEEVEWSNFSHFNAESALADMNDSVEVTEEATVVTIS Schizosaccharomyces pombe NYSGXRC-6122d SGX Pharmaceuticals 2004-01-26 active Selected EC4978 MKYIFVTGGVVSSLGKGVASASLGALLRARGYKVTAVKIDPYINIDAGTMRPYEHGECFVTASGAETDLDIGNYER FLDLDIPAGSNITTGQVYQEVIRKERAGDYLSQTVQVIPHVTDEIKRRIRAAGESAGAEIVLIEVGGTVGDIESL PFLEAIRQFRFDEGDDNVLYLHLTLVPYLGTSNEFKTKPTQHSVAALRSYGISPDIVMVRSKDKLPAEITRKIAA FTSVRENRVFSSYDVEHVYQVPLALEEQGLGKAVEELLGLEGTHPRLGVWTDAVRTIKHPKQQVTIAIAGKYTAM PDAYLSLMESLTHAGIANDARVNIKWVNAEQLAEAGAGELEGQFADVDGILVPGGFGIRGIEGKVKAAEYARTHG VPYLGICLGMQIAVIEYARHVAGIEDANSAEFDEYAKNKVIDLMPEQLEVAGMGGTMRLGDWPMELRAGTKIAEL YGVPQGGTVKERHRHRYEVNPAYVEQLEAAGLTISGVTPGVEGRGAGLVETVEIADHPFFVALQAHPEFKSRPMR PSPPFAGFVKAALEHQQQ Deinococcus radiodurans NYSGXRC-6123a SGX Pharmaceuticals 2004-12-04 active Selected Cloned Expressed Soluble Purified EC989 ICEDB: T2202 GENBANK NP_416411.1 VTEPLTETPELSAKYAWFFDLDGTLAEIKPHPDQVVVPDNILQGLQLLATASDGALALISGRSMVELDALAKPYRF PLAGVHGAERRDINGKTHIVHLPDAIARDISVQLHTVIAQYPGAELEAKGMAFALHYRQAPQHEDALMTLAQRIT QIWPQMALQQGKCVVEIKPRGTSKGEAIAAFMQEAPFIGRTPVFLGDDLTDESGFAVVNRLGGMSVKIGTGATQA SWRLAGVPDVWSWLEMITTALQQKRENNRSDDYESFSRSI Escherichia coli NYSGXRC-6123b SGX Pharmaceuticals 2004-06-01 active Selected Cloned Expressed Soluble EC989 GENBANK NP_456495.1 VAEPLTVSPELTANYAYFFDLDGTLAEIKPHPDQVVVPHKILQLLDRLAAHNAGALALISGRSMTELDALAKPFRF PLAGVHGAERRDISGKTHIVRLPEAVVREVEALLRSTLAALPGTELETKGMAFALHYRQAPEHEAALLALAQHVT QHWPQLALQPGKCVVEIKPKGTNKGEAIAAFMQEAPFTGRIPVFVGDDLTDEAGFGVVNHAGGISVKVGVGATQA AWRLESVPDVWRWLEQINYPQQEQQVMNNRRDGYESFSRSI Salmonella typhi NYSGXRC-6123d SGX Pharmaceuticals 2004-12-10 active Selected Cloned Expressed Soluble Purified EC989 ICEDB: T1733 GENBANK NP_111774.1 MIDGLLITELNKLTPGSSYIFLDYDGTLVPIIMNPEQSLADPELIEMLTELRSKYKLFIVSGRSPEEIKRFIPLDL NLICYHGACSIVNGKTYYYNNAQSFLGIFNEIYQSSLNLVNEFPGLRIYKKNLAVLYHFGLMKPQDVPALERVIV EISQKEHVDVYKGKMIFELRVPGVNKGIAIKNVRDEETALIAGDDATDECSFKYNEDAITIKVGPGKTSAHFRVN DYSEMREVLKLLLNNAEKRS Thermoplasma volcanium NYSGXRC-6123e SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC989 ICEDB: T1701 GENBANK NP_217889.1 VRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFGSGLDVPIVAAGRLAVRPGRCVVVSAHSAGVTA ARESGFALIIGVDRTGCRDALRRDGADTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVARQPAVFFDFDGT LSDIVEDPDAAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFELTAPDGTHHQNDAAAA AIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAVRTAEQRHALRVTTGREVIELRPDVD WDKGKTLLWVLDHLPHSGSAPLVPIYLGDDITDEDAFDVVGPHGVPIVVRHTDDGDRATAALFALDSPARVAEFT DRLARQLREAPLRAT Mycobacterium tuberculosis NYSGXRC-6124a SGX Pharmaceuticals 2004-03-16 active Selected Cloned Expressed Soluble Purified EC2726 ICEDB: T1799 MKVVFVSYEVFPFAKVGGLADVAGTLPKYLKKHGVDVTIVMPKHRIVEKNAEKFGYEIKKVAESLSVSHVKTDQKF DIYESVLPGSDVKTYFVANDYYFSAEDVYAGPDLGEQAIFFCAATLDLVKHLDLKPDIVHVNDWQTALIPVYLKT VYRDDPYFSRTATVLTIHNLGYQGVFDPKYLSFAGLPDYVYTIDGLEFYGQLNFLKGGIVFSDVINTVSPTYAEE IQTEEYGEKLDGVLRMRSKDLYGILNGIDYELYNPATDRYIYVNYDVNRLELKWENKVKLQEELGLPVNKETAVA GLISRLVPQKGLDLLVDVMDYLTLFDLQIVVLGTGDEQYENAFRKFQERYPDKVSANIKFDVELAQKIYAGADIF LMPSRYEPCGLGQMFSMRYGTIPVVRYTGGLADTVKEYDPQSMEGTGFGFKKYDSAHLLKAVSKALHFYYREKDH WRRIMTNAMNTDLSWDRSAKEYVDLYKKALAKVGR Thermotoga maritima NYSGXRC-6124b SGX Pharmaceuticals 2004-03-10 active Selected Cloned Expressed Soluble EC2726 MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYYDMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKK TVLNGVTFYFIDNQYYFFRGHVYGDFDDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYRWIQ AYEDIETVLTIHNLEFQGQFSEGMLGDLFGVGFERYADGTLRWNNCLNWMKAGILYANRVSTVSPSYAHEIMTSQ FGCNLDHILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAKNKAKLQERVGLPVRADVPLVGIVSR LTRQKGFDVVVESLHHILQEDVQIVLLGTGDPAFEGAFSWFAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSR FEPCGLSQMMAMRYGTLPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNLQ KQAMESDFSWDTACKSYLDLYHSLVN Streptococcus pneumoniae NYSGXRC-6124c SGX Pharmaceuticals 2004-01-26 active Selected EC2726 MRILFVAAEAAPIAKVGGMGDVVGALPKVLRKMGHDVRIFLPYYGFLPDKMEIPKDPIWKGYAMFQDFTVHEAVLP GTDVPLYLFGHPAFTPRRIYSGDDEDWRFTLFSNGAAEFCWNYWKPDIIHCHDWHTGMIPVWMNQSPDITTVFTI HNLAYQGPWRWYLDKITWCPWYMQGHNTMAAAVQFADRVNTVSPTYAEQIKTPAYGEKIEGLLSFISGKLSGIVN GIDTEVYDPANDKYIAQTFTADTLDKRKANKIALQEEVGLEVNSNAFLIGMVTRLVEQKGLDLVIQMLDRFMAYT DAQFVLLGTGDRYYETQMWQLASRYPGRMATYLLYNDALSRRIYAGTDAFLMPSRFEPCGISQMMALRYGSIPIV RRTGGLVDTVSHHDPINEAGTGYCFDRYEPLDLFTCMIRAWEGFRYKPQWQELQKRGMSQDFSWYKSAKEYDKLY RSMYGLPDPEETQPELILTNQ Nostoc sp. NYSGXRC-6124d SGX Pharmaceuticals 2004-12-01 active Selected Cloned Expressed Soluble Purified EC2726 ICEDB: T2191 GENBANK NP_241951.1 VNVLHVASECNPFFKTGGLADVLGSLPKALIKQGINVSVILPKYGHLSDEWQNQLTLKKSFTVSVTWRNQYCGLEQ FVDQGVTYYFIDNEYYFKRERLYGYLDEAERFTFFNHAVLSSLPFLDESPDLIHCHDWQSGLIPAYMKTGSVENP VPTVFTIHNLRYQGAFPPDVFRELLHFAPEHFAGLEMDGAINFLKGALVHSDRVTTVSPTYAQEIQTPAFGEGLH GLLHQERGKTRGILNGIDLEDFDPKTDPHVTYPYKHNQMEKRKNKQVIQRLFELPERKDIPLIAMVSRLVEEKGV PLLTQIAGELVTTENVQLAILGTGDPSLEDQLHHLASLHPHQISFKCVFAEPLARKLYAGADLFIMPSRFEPCGL SQMISLRYETVPIVRETGGLYDTIQSYNEEIGEGNGFSFTHYNAHDFLYTIKRALRFYRTEKEWENLLLNIYSSE VGWDVSAKQYTALYEEILGKRKVEA Bacillus halodurans NYSGXRC-6125a SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC2240 ICEDB: T1715 MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLF NVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEF LEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPAN AQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVD GRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVS GQDVAAALEANAKSVESRGKSKFIHDAAVKRRVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTK DIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYG SRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDL EAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSI EFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSL THMVEAAKYFREQYKN Saccharomyces cerevisiae NYSGXRC-6125b SGX Pharmaceuticals 2004-01-26 active Selected EC2240 MTIVTNLSFPRIGARRELKRALESHWRGETDATQLQHTARELRARHWQLQRDTGVDLPPSNDFSLYDHVLDTAFLF DAIPQRYRALADADPLAGYFAMARGRQADGIDLHALEMTKWFDTNYHYLVPELHRDQHFALRGNKPIAEFEEALA LGITTRPVLLGPVSFLLLSKTVDGSNRLDLLERLLPVYTQLLRQLQASGAEWVQIDEPTLVLDLDAQTQQAFRKA YAALNQGPRPKLLLTSYFGPLGDNLELALQLPADGLHIDLVRGTEQLDAVLNTLPAGRVLSAGLVNGRNIWRTAL DNALTLARYAQGRIGKDHVWLAPSCSLLHVPVDLEQEKNLDADVRNWLAFAKQKLSELRVLADALDNKPEAETAL TQTRQALEARRQSPKVHRPEVAQRLAALTPDTTQRNTAYPQRSQAQQQTLNLPAYPTTTIGSFPQTLEVREARAQ FKSGKLSESDYETFLKAETERCIRTQEEIGLDVLVHGEFERNDMVEYFGEQLDGFIFTKLGWVQSYGSRCVKPPI IYGDVVRPAPMTVTWSAYAQSLTDKPMKGMLTGPVTMLQWSFVRDDQERAQTCRQIALALRDEVQDLEKAGIKVI QIDEPAIREGLPLRRGEWADYLNWAVESFRIASSNVRDTTQIHTHMCYSEFNDIIEAVAALDADVISIETSRSRM ELLDAFVKFRYPNAIGPGVYDIHSPRVPQEEEMVLLLKKARAVLPPEQLWVNPDCGLKTRGWKETRAALQTMVHA AQRLRAE Xylella fastidiosa NYSGXRC-6125c SGX Pharmaceuticals 2004-02-27 active Selected Cloned Expressed Soluble Purified EC2240 ICEDB: T1680 GENBANK NP_214172.1 MVKTYAFGFPKLGEKREFKRLLENYWKGKISQEELIKGMEELNLWRANLYRENVEIIPSNELSYYDFMLDTTVMVG AIPSRFGEYRGLDTYFEMARGKNALELTKWFNTNYHYLVPELEGENFKLLINRPLEDYKFFKEKGINTVPHVIGL FTFLKLSKAPKRVEEEGLPVIILEKLDTKERLEKFTKALLPVYKELLESLKNEGVNRVHFEEPALVTDLEDYDWE ILNEIYSELSKVGVDLGILTYYDSVSDYDKFVNLPVKALHFDLVSNEENLKNIKEKGFPEDKELIAGIINGRQPW RANLREKVKLLEELLKVSANLVVSNSCPLYHLPVTVEPEDELPEGLKERLSFAKEKLREIRLIKEALEGKEEALR EVESSEKVMTAVFAQNPEVRRRLASLSEKDFQRELPYKERDKIQRDILKLPLFPTTTIGSFPQTEDVRKMRTAYR TGKISEEEYKNFIKQKIKYAIEVQEDIGLDVLVHGEFERSDMVEYFAIKLDGIATTKHGWVLSYGSRVYRPPIIY GDVSRPAPMTLEEITYAQSLTNKPVKGMLTGPVTILNWSYYREDVPKREIAYQIALALLDEVKDLENAGIKVIQI DEPAFREGAPLKKRDWPEYFDWAVKAFRLASRAKPETQIHTHMCYSEFNEIIEYIYQMDFDVISIEASRSKGEII EVFEKFKGWDRQIGIGVYDIHSPAIPTKEEMKAIMLRAMKVLPKELLWVNPDCGLKTRRWEEVIPALRNMVDMAK ELREEVGVKV Aquifex aeolicus NYSGXRC-6125d SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC2240 MGDADEPWREFFGFEAPYDQQADAIGAAIEAGDSDGFLAMEGPCGTGKTMAALTAGAHLVRNTDSYERVLVVTPVK QQLEQFVADLRTMNAGLDDPLDGVALVGKRDLCPYEREDKFPDDAGVHERCEDLRESTAGLVEGDDGGEFDGQDA RDLTELPAAETPDEPWWDPAAGRALARSARADASQTLSQTPLRTAGTDAPYVPHQPTAPEDMADGDPPLMCPFEA DWYGRDKGSPVGFETGQHNVVTSADVLPAGVDHGTCPHRVQQVLLDHAEVVVGNYNHLFDPQTRGLTDHLIDDST FVVVDEAHRLEERVRDLLSDRLGRHTLTRARNDCRTLLTRANQSRENRQQVTDHLASHDCSLDAVEAMVGFLDDV LEWLDDRVARYLAAEGFDPDRPGSLPERDHEIPLRDPESEQPDALTQWAEQHGHTGDAWRSLAATGTAVQAILDD DGDRSAVAGPVGVTLQRWWERDHATYFREVELEHVPKESGRAGAAWAESYTPALVMFNCMPARALRETLSEVGGG VLMSATLEPLDVFREVAGLDRLAAGAGDSDPRPVVERRYDLRFPESNRASFLVDATPFTAHNRGDPEPGTDNPTR DEYRYVLRTVARQPGNVLVCMPNYREAAWAAAYLSDGVVEKDVLVDESSSNAATDDLKATFFAGDGKVLVTSTRG TLTEGVDYDGAKLGACLVVGVPLVNVGSPRIRAVRRAYADAFGDDHAFEYALTVPAVRRARQAIGRVIRGPEEVG VRVFAGGRYVEDARHSVFEYLGPGERAEFTTLTPSFLGSQLDAFRSESD Halobacterium sp. NRC-1 NYSGXRC-6125e SGX Pharmaceuticals 2004-07-13 active Selected Cloned Expressed Soluble Purified EC2240 ICEDB: T1696 GENBANK NP_439844.1 MTTSHILGFPRVGAKRELKFAQERYWRKELAEQDLLDLAKALREKNWKHQAAANADFVAVGDFTFYDHILDLQVAT GAIPARFGFDSQNLTLDQYFQLARGNKDQFAIEMTKWFDTNYHYLVPEFQKSTAFKANPAHYVNQIREAKALGLN FKPVIVGPLTFLWLGKEKGEAFNRFDLLNQLVPVYVEILNALVAEGAEWIQIDEPALALDLPAEWVEAYKSVYTE LSKVNAKLLLATYFGSVAEHAELLKALPVAGLHLDLVRAPEQLAAFEDYSKVLSAGVIEGRNIWRANLNKVLDVL EPLKAKLGERLWIAPSCSLLHTPFDLEVEVQLKEKNTALYSWLSFTLQKVEELNVLKQALNNGRASVQAALDASQ VAADARATSKEIHRPEVAERLANLPKGADQRKSPFAERIVKQNAWLNLPLLPTTNIGSFPQTTEIRHARASFKKG ELSLADYEAAMKKEIEYVVRRQEELDLDVLVHGEAERNDMVEYFGELLDGFAFTKFGWVQSYGSRCVKPPVIYGD VTRPEPMTVRWSQYAQSLTNRVMKGMLTGPVTILQWSFVRNDIPRSTVCKQIGVALSDEVLDLEAAGIKVIQIDE PAIREGLPLKRADWDAYLQWAGEAFRLSSMGVQDDTQIHTHMCYSEFNDILPAIAALDADVITIETSRSDMELLT AFADFKYPNDIGPGVYDIHSPRVPTATEVEHLLRKALNVIPKERLWVNPDCGLKTRGWTETIDQLKVMVDVTKKL RAELA Haemophilus influenzae NYSGXRC-6126a SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC4280 MISIKGTGRFLLDNYRIWQRRAFNRPIQLRKGYKVLAIETSCDDTCVSVLDRFSKSAAPNVLANLKDTLDSIDEGG IIPTKAHIHHQARIGPLTERALIESNAREGIDLICVTRGPGMPGSLSGGLDFAKGLAVAWNKPLIGVHHMLGHLL IPRMGTNGKVPQFPFVSLLVSGGHTTFVLSRAIDDHEILCDTIDIAVGDSLDKCGRELGFKGTMIAREMEKFINQ DINDQDFALKLEMPSPLKNSASKRNMLSFSFSAFITALRTNLTKLGKTEIQELPEREIRSIAYQVQESVFDHIIN KLKHVLKSQPEKFKNVREFVCSGGVSSNQRLRTKLETELGTLNSTSFFNFYYPPMDLCSDNSIMIGWAGIEIWES LRLVSDLDICPIRQWPLNDLLSVDGWRTDQL Saccharomyces cerevisiae NYSGXRC-6126b SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC4280 MLCLVYNSILCKQRRISLKVLQQFRCWNISKTFLSYRTLTALAIETSCDDTSVSVVRTSDSSSHCQNEIICLNTHR TISKYEAYGGIHPTIVIHEHQKNLAKVIQRTISDAARSGITDFDLIAVTRGPGMIGPLAVGLNTAKGLAVGLQKP LLAVHHMQAHALAVQLEKSIDFPYLNILVSGGHTMLVYSNSLLNHEIIVTTSDIAVGDYLDKCAKYLGIPWDNEM PAAALEQFASPEINSTSYSLKPPIPLNTREKVHSASFSFSGLESYACRIIRKTPLNLSEKKFFAYQLQYAAFQHI CQKTLLALKRLDLSKVKYLVCSGGVARNELLKKMLNDTLMVLQFEHQPTDIKLVYPSPDICSDNAAMIGYTAIQM FKAGYTSSFDVEPIRKWPINQILTVEGWLTKKNKKV Schizosaccharomyces pombe NYSGXRC-6126c SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC4280 MKVLGIETSCDDCCVAVVENGIHILSNIKLNQTEHKKYYGIVPEIASRLHTEAIMSVCIKALKKANTKISEIDLIA VTSRPGLIGSLIVGLNFAKGLAISLKKPIICIDHILGHLYAPLMHSKIEYPFISLLLSGGHTLIAKQKNFDDVEI LGRTLDDACGEAFDKVAKHYDMGFPGGPNIEQISKNGDENTFQFPVTTFKKKENWYDFSYSGLKTACIHQLEKFK SKDNPTTKNNIAASFQKAAFENLITPLKRAIKDTQINKLVIAGGVASNLYLREKIDKLKIQTYYPPLDLCTDNGA MIAGLGFNMYLKYGESPIEIDANSRIENYKNQYRGKNNEKNFSNA Borrelia burgdorferi NYSGXRC-6126d SGX Pharmaceuticals 2004-03-03 active Selected Cloned Expressed Soluble Purified EC4280 ICEDB: T1697 GENBANK NP_438688.1 MKILGIETSCDETGVAIYDEEKGLIANQLYTQIALHADYGGVVPELASRDHIRKTAPLIKAALEEANLTASDIDGI AYTSGPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPMLDDNSPHFPFVALLVSGGHTQLVRVDGVGKY EVIGESIDDAAGEAFDKTAKLLGLDYPGGAALSRLAEKGTPNRFTFPRPMTDRAGLDFSFSGLKTFAANTVNQAI KNEGELIEQTKADIAYAFQDAVVDTLAIKCKRALKETGYKRLVIAGGVSANKKLRETLAHLMQNLGGEVFYPQPQ FCTDNGAMIAYTGFLRLKQGQHSDLAIDVKPRWAMAELPAI Haemophilus influenzae NYSGXRC-6127a SGX Pharmaceuticals 2004-03-26 active Selected Cloned Expressed Soluble Purified EC1522 ICEDB: T1800 GENBANK NP_390902.2 MMQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFMQIQFEEVHESIKTIQ PLPVHTNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDW PDANFEKWALHSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGC RVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS Bacillus subtilis NYSGXRC-6127b SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC1522 ICEDB: T1689 GENBANK NP_347173.1 MNSYVLGFKEIDKTKISMVGGKGANLGELSRVAGILIPEGFCVTTEAYKKIIEKSKEFNELLDELSCLRLEDGEKV YEVSKKIRMVIERISIPKDIVEEIDVYLTRLGEKDAYAVRSSATAEDLPTASFAGQQDTYLNIIGKKSILEHISK CWASLFTDRAVIYRLQNGFDHRKVYISVVIQKMIFPKAAGILFTADPVNSNRKVLSIDASFGLGEALVSGLVNAD MYKVLSGKITDKKVSKKKLAIYASKDGGTKAQELEIEKQNKQVLTEEQILQLEHIGRSIEEHFSFPQDIEWCLNQ DTFYILQSRPITTLYPIPKANDEENHVYISVGHQQMMTDPLKPLGMSLYELTSFGNRFKAGGRLFFDVTQMLASK DSRKMLLNNMEQHDPLMKDALVTIIERDFIKALPSDNGNQSKSNKGVSAGESENQIENNPTIVSDLINKNQASIE ELKENIKTKSGLELIDFIRTDVEELKKILSDPQSSAVFMTAINASHWINEKMRDWLGEKNAADILSQSVPNNITS KMGLELLEIADVIRPYPEIIDYLQHVKDDNFLEEIVKFNGGHEVKNAILSYLSKYGMRCSGEIDITRTRLSEKPI TLVPMILNNIKNFETGAANIKFQQGKQKALEKEQELLERLKQLPDGEQKAKETKRMIKLIRNFIGYREYPKYGMV NRYFIYKQALMKEAEKLANIGAIHEKEDIYYLTFEELREVIRTKKVDYSIINKRKNEHKLYEKLIPPRVITSDGE IVEGEYKRENVPEGAIIGLSVSSGVIEGRARVILNMEDANLEAGDILVTSFTDPSWTPLFVSIKGLVTEVGGLMT HGAVIAREYGLPAVIGVENATKLIKDGQQIRVNGTEGYVEIL Clostridium acetobutylicum NYSGXRC-6128a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC1037 MDKINPDWAKDIPCRNITIYGYCKKEKEGCPFKHSDNTTATTINDVPPPIDVGEATTPTMTSVPKFNAKVSASFTP MTVGSDSLTTVTNTTSAATNATGNIAMAATSATASTVNPMINPIVNSSLVNNNNNNSNISISIPTTASSSNYDPF NAPIFTPSSTSSIHTNANAHSFPFPSIANSGGININATDDNSNNMSMANNVPPPMQPPPIESSNLKYPRIYPPPH SLLQYHLYAPEQPSSLKSLLKPNERSADQLFIPNNIREDLTKKNLSILQVFPSSGKVIPSIVQDYFNLVPLNFNN NDFLNKTTLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLSICLVFD YYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNWRKVLITGDPGRIKLSHCNFMDL LFNDDTDTVVSSGGSTIEGQQQLDYKYLGELLFNLSINIENSNNNTAPKEYRLEEITPQSIDDMRQIDDKFKDVL KYLISDNGDSKKSIHDLTSHFYDKMFMVLESSQTYTEYMESVLSRELENGRLFRLVNKLNCIFGRIESRIDINWS ESGTKFPIILFYDYVFHQVDSNGKPIMDLTHVLRCLNKLDAGIQEKLMLVTPDELNCIIISYKELKDLIESTFRS ITQ Saccharomyces cerevisiae NYSGXRC-6128b SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC1037 MKRMLINATQAEELRVAIVDGQSLYDIDIEQPSKEQKKSNIYKGRITRLEPSLEAAFVDYGTDRHGFLPLKEISKD YFQAGLDHHKAGIRELLREGQEIVVQVDKEERGNKGAALTTFISLAGRYMVLMPNSPSAGGVSRRIEGEDRAALK EALEKLNIPNDMGVIIRTAGVGRDTQELQWDLDFLLHAWRAIAEAALSKPAPLLIYQESRLIIRALRDYFRADIG EILVDTEEMYQDAHEFMRHVMPQSLRKLKYYKDDIPLFNRFQIESQIEGAYERNVRLPSGGSIVVDQTEALTAID VNSSRATKGNDIEETAFQTNLEAADEIARQLRLRDVGGLVVIDFIDMSSSKHQREIETRLQNCLKYDRARVQLSR ISRFGLLEMSRQRLRPSLGESSQIVCPYCDGHGRMRSIESLSLSIIRIVEEHAMKENTGQVLVQTPVEIANYLLN EKRRAINEIEKRHDAPIIIIADEQLHTPHYEVTRLRENELSEETGKPSYQRNTPRKLPVHALTKSQLNIPPAPAV KSIPPPQLAPTQENIPTIREQSAENRAHPIPELVSSLASWLKRIFGNTDKRQTASNSSHPAPLQQNRNGNVQRNE RNHRDGRIATSNTQPQQQSSNHRDNYRHNESNNYPQIQNQSTADTNGKLRNESQTPKSSAYVSKQPQMPRQPQPQ LPKTPRTQSQPTQNSTKTTLDKQPAPVLYGEDNTLQKAKPIPLTAEAVLTNMPAPSMTATPSGKDQNALPTTSNV TQDTSNALIEAQSTTKTNIDTNTDIEPQQNNHEGTANNDGSNRRRRGRRGGRRRRRNTSLGNETNAVSESNSIKL SNDTETDNADNIEAPQALRPAMQENKRQPEFEFDDLAPAAPITAPLRKAIAAEREEISADLTTTAPQSMMETTSR THVASQMAPQSETSAASTTSHTSVQATTTHTHKDVVSDSPSRTPYKAHSNTTRHTSGRRLETLSTAHTPAKASPS EHITPTSRSNANAKTTKTEIPNKPTNANSDTAARPTATDVLVVTNQPVMATKPSTTIEKAQTKVVPSTTYNNEHI ETKRKIIATESETTQPPVRKPRLPMQNPLPKVVAPLEDKKQAPFVENTTQRNINNATTTSQNDKLLDFTKNNEKN SDNNTL Xylella fastidiosa NYSGXRC-6128c SGX Pharmaceuticals 2004-01-26 active Selected EC1037 MRISSAALLTLTTLVASNATQQAIAAPHTASTPSKQNENLVIPVVEETPVQLGNVTPPETEVTPQFSTKSRVIAQN SPVVLPSTPRPVVPPAPKPATTVNELVVTATDVQIVGATPELQEIIRQVIKTQTGGDTSQTQLQRDVAAILETGL FASANVNSRTTPSGLNVVYQVQPVIVRSLQLTGAKALTYSVAQPRFQSQIGKPISPEGLKQAVAQVNQWYADNGY NLARVLSIEPNRQGILNINVAEGLVSDIKFRFVNDDGKTIDSNGNPVGGRTKPDFLRQQLKLQPGQVFQENIVKQ DVQQLYRTGLFQSVNVAFAGDATKLDMIYELKENGARAINLGGSYNGDVGLMGTLNYQDQNIGGKNDTLLANVGL SRTDLQFDTKFISPYRDTNSDRLGYTVNAFRRREISETFDDEIKLANGDKVREGKVGTGISLQRPIDGWNASLGF NYSRTSIRDRQGNITPTDAQGNPLSVSGTGVDDLTTVSFSATKDQRDNPINPTQGSVVRVSTEQSVPIGQGNISM NRLKADYSQYVPVNIFNSQTPQVFALNVQAGTVLGNLPPYETFNLGGSNSVRGYDAGNVGSGRSYVLASAEYRFP IVPIVGGVLFADFASDLGSGDTVLGNPAGVRGKPGSGFGYGAGIRVDSPLGLIRADYGINDQGESRVHLGIGQRF Nostoc sp. NYSGXRC-6128d SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC1037 GENBANK NP_045618.1 MRLCLIKIFIIPNLVFSSLFLFESCSGFLSKKSIEQFALALKDHQENKNTTNTSVDKNSKEIESPKDVTSSNKKTY DPILQVGSNQHMSDDPGANNKESLPNSSPAIIQNDSHAQNNVKMEENKSATPQHDPIEQSNFKNSLTTTSKTPAI PSEEEIKANLDEFAQEEYEQTSLSEIKNATQIVNHANPENKLNNTLLEFEKDYETLSNLLFSNLDASPLNRKIKT IMPKLQEMRSFMEQATNSWVSAKGMLDEAKDKLAESIYKRLYNGNSYRFGGSFNGRDMQHAKNLAYRAIDFASAC IEYTQKAIDYLQQGNSCKKEIENIFKL Borrelia burgdorferi NYSGXRC-6129a SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC2631 MNLTLRPAGVDDLSALVELENRCFDYDRLSRRNFQWMLTRAHASLTVAEGDGGVLGYALVLFHEGTSLARLYSIAI DPRARGIGLGQKLLEAAEQAARDNDRAYMRLEVRPDNRGAIALYERNGYRPFATVRDYYEDHSEALRFEKRIRNP GHDQRRHVPFYRQTTDFTCGPACLLMAMGALQPERQLTRREELRLWREATTIYMTAGHGGCSPQGLALAAWRRGF RVKLVLSAGGPLFLDGVRNEDKKAVMRLVHEDFCEELDASGVEQKRSARLDIPRQLARGGQPLVLISSYRLTRSK APHWVLVTHYDEDFVYLHDPDVDHSQHRQPLDCQHIPVSHAEFDKMSRFGRSKLRAAVILFNPE Pseudomonas aeruginosa NYSGXRC-6129b SGX Pharmaceuticals 2004-03-13 active Selected Cloned Expressed Soluble Purified EC2631 MEDFAESEGGVKKKIPISLVTIRSAKLFDIPFIMRIEQASFREKYPRGLFLTFLESNPDTFLVAEYNGKVIGYVMG YLRPDMEGHIMSIAVDPNYRGNGIGKALMIAVINKLFKKGARWIGLEVRVSNVIAINLYKKLGFKITKRIYSYYS DGEDAFYMILTPEDWKRVNLE Pyrococcus horikoshii NYSGXRC-6129c SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2631 GENBANK NP_341764.1 MTYILRRSQLLLIVSSYQLVHYLCSQLSSLKDASCMCAYILTTLYKDIDMELAEKDKGRDFTLRNARMDDIDQIIK INRLTLPENYPYYFFVEHLKEYGLAFFVAIVDNSVVGYIMPRIEWGFSNIKQLPSLVRKGHVVSIAVLEEYRRKG IATTLLEASMKSMKNDYNAEEIYLEVRVSNYPAIALYEKLNFKKVKVLKGYYADGEDAYLMARPL Sulfolobus solfataricus NYSGXRC-6129d SGX Pharmaceuticals 2004-05-25 active Selected Cloned Expressed Soluble Purified EC2631 ICEDB: T1909 GENBANK NP_213398.1 MLKVREMEREDVERVYEINRESFTTDAWSRFSFEKDFENKFSRRFVLEEDGKVVGYVIFWVVKEEATIMTFAIAPG YRGKGYGEKLLREAISRLGDKVKRVVLDVRKSNLRAINLYKKLGFKVVTERKGYYSDGENALLMELKISRPSEAE LSR Aquifex aeolicus NYSGXRC-6129e SGX Pharmaceuticals 2004-04-02 active Selected EC2631 MNTLKTSPLPVRLCTLRESHLDKVMEIERRVYCFPWTRAIFRNCLQSGHLALLMKQGRNMIGYGIVNITRKEAHLL NICIAPEQQSHGLGRSLLRTLIKRSCNSGAQCMFLEVRPSNTVAIALYHSEGFNEIDRHRHYYPAQNGYEDALVM GIEFS Xylella fastidiosa NYSGXRC-6129f SGX Pharmaceuticals 2004-05-17 active Selected Cloned Expressed EC2631 GENBANK NP_069357.1 VEIRRADKDDLDDFVRVYVESYRGLEDYAYTRKRDVKNYFKWLLSRDKDGVMVAEIDGEAVGFVACDTNWFSIFER KKVGEIHELFVLPEFRGEGIGAKLMEKALEYALERNRKVAELWVGRTNYRARRFYASQDLRRPESGGSGSE Archaeoglobus fulgidus NYSGXRC-6129g SGX Pharmaceuticals 2005-02-23 active Selected Cloned Expressed Soluble Purified EC2631 GENBANK NP_269295.1 MLRPLSKTDCPMLQEINAKALGYLVSLDLLERQYERLIEDCHHYFLAYADKDTNQLLGYVHAERYETLYASDGLNL LGLAVLPAYQRRGIGSALLRALESQARQEGIAFIRLNSASHRKEAHAFYRNLDYADDKTQLRFIKNLQGDDNDF Streptococcus pyogenes NYSGXRC-6129h SGX Pharmaceuticals 2004-12-10 active Selected Cloned Expressed Soluble Purified EC2631 ICEDB: T1725 GENBANK NP_345969.1 MKIRQARLEDLDRIVELEFENFSVEEAIPPSVFEAHLREIQTSFLVAEKEGRIMGYIEGPVGLHRHLQDQSFTEEI KDYSHEPGGYISVTCLSIAKEAQGLGLGQKLLTALKEVALEDERDGINLTCHDYLIAYYEKHGFVNEGQSQSTFA GETWYDMVWEMKK Streptococcus pneumoniae NYSGXRC-6130a SGX Pharmaceuticals 2004-01-26 active Selected EC2135 MSRHPLKIVIAGAGIGGLAAAACLKAAGFEVELYERARELRAVGSALSLMPNALTALERVGVRPDLTRAQAFDSLR FLTRRGRPIRAIDFGGLARQLGQPSLAIHRASLQQALLEQARDCRIELGVSATGYLRHADGEGVTVLCSDGREVH ADVLIGADGFNSAIRATMTGPERPTDWHYVIWRATPAFRHPKVTPGYVAHYWGRGQRFGLADIGEGNVYWWGTRN MPAEQAKDWRGGKAGIQRLYAGWADEVQAVIEATPEADISSLPAQDRPFLERWGDGPVTLLGDAAHPMLTSLGQG AAIAIEDAAVLAHCLATIDDPQAALRAYENRRRDRARAMVETSRALSRIEQLEHPLRTVARDLYFRFAPERTFAR QNELALTFPGVE Pseudomonas aeruginosa NYSGXRC-6130b SGX Pharmaceuticals 2004-03-12 active Selected Cloned Expressed Soluble Purified EC2135 ICEDB: T1726 GENBANK NP_461120.1 MTHVTSAIIVGGGIGGAATALSLARQGIKVMLLEKAHEIGEIGAGIQLGPNAFSALDSLGVGDVARQRAVFTDHIT MMDAVNAEEVVCIETGQAFRDHFGGPYAVIHRVDIHATVWEAVLTHPGVEYRTSTHIVDIRQTPDDVTVFDEQGN SWTADILVGCDGVKSVVRQSLLGDAPRVTGHVVYRAVIDCDDMPDDLRINAPVLWAGPHCHLVHYPLRGGQQYNL VVTFHSRQQEEWGVKDGSKEEVLSYFAGIHPRPRQMLDKPTSWRRWSTADREPVAKWGTERITLVGDAAHPVAQY MAQGACMALEDAVTLGKALERCDGDAQQAFALYESVRIPRTARIVWSTREMGRLYHAAGVERQVRNLLWKGKSQE AFYRGIEWLYGWKEDNCLEPR Salmonella typhimurium NYSGXRC-6130c SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC2135 GENBANK NP_242714.1 MGRRPKKSSYDVVVIGAGMGGLSAATFLAQEGYSVLVLERHYRAGGYAHSFRRRKFIFDSAVRIAAGAMDGGLLEE LLQEAGVSQDVEFLHLEDIYTAYYPNRKITVKGSVEGLIEAYCEEFPHECHNIRALVQEMEKLYEVTLMLLHSGD PLKVLSNPLMLKYRDKSFHDLTSSFLQDPQAIHSFAALWAYYGTPPTQGSAMFFAYAIMSYFKEDIYYAKGSFQS LADAFVKRIESLGGEVCLRNEVQRVEVEDRQIKGVHLQTGEYVEAEKVVCNGDFLKLVQHLVGEEHFPARYLKRI SKLKPSISAFEVFLGVDLPLEKQGLSHETFIYNDYDYDLFMEKHQSLGEIGASGLSGLAISIPSLVDSSLAPEGM HTAILTTLVPYDIGCDWKEKKEDYQDQLIKMAERAIPNLGRHAVHVESGTPLTMERYTNNSFGSIYGWEQTKNQM TGRPQHETPIKGLYLSGQWTDPGGGIVSAILSGYKLRKKIMKEQVVM Bacillus halodurans NYSGXRC-6130d SGX Pharmaceuticals 2005-02-23 active Selected Cloned Expressed Soluble Purified EC2135 ICEDB: T1887 GENBANK NP_354573.1 MPIKSVAIIGAGIAGLTAALAFARHGIDCDIIEQTGELAEVGAGLQLSPNAARILATLGVLPDIEARWTEPVSVDL ASGKSLTTLLSLPMGAVARSRWGAPYGVLHRSTLQSALLQAVTRNPLCRLHLGKRIENATADVIAATTFRDHDLI VGADGVWSAARFSVPAAPTATFSGNVAWRFTVAAEEVPSAFNKTTVTAYLGSRGHIVAYPLKEVGGFNIVAIALG ADPGATWRAESSGRQKALLLEQFRDFSPDIVRLLDSSENPTFWPLYQAGPGRWHNGRDTVLIGDAAHAMMPFAAQ GAAMAIEDAFELAGTMAGSNGEKPLPVPQALAAFEALRLPRIEKARKRASLNRFAYHARGPVRIARDLVFSTRPP EAFLKDFDWLYGYHARG Agrobacterium tumefaciens NYSGXRC-6131a SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC1196 GENBANK NP_217936.1 MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEALGPAMRRALAAAGLKQP DIVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLG EPIIELGSTVDDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARY VESHAADPGFRTADIAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPSP RLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQGQVR Mycobacterium tuberculosis NYSGXRC-6131b SGX Pharmaceuticals 2005-06-28 active Selected Cloned Expressed Soluble Purified EC1196 ICEDB: T1685 UNIPROT Q9KFD3 VGDVVMNERELILAIETSCDETSAAVIENGTTILSNVVSSQIDSHKRFGGVVPEIASRHHVEQITVIVEEAMHEAG VDFADLAAVAVTEGPGLVGALLIGVNAAKAIAFAHQLPLIGVHHIAGHIYANRLLKELEFPLLALVVSGGHTELI YMENHGEFEVIGETRDDAVGEAYDKVARTLGLPYPGGPHIDRLAVNGEDTLQFPRAWLEPDSFDFSFSGLKSAVI NTLHNAKQRGENVQAEDVAASFQASVIDVLVTKTKKAAEEYKVRQVLLAGGVAANKGLRTALEEAFFKEPIDLVI PPLSLCTDNAAMIGAAASIKFKQQTFAGMDLNGQPSLELEND Bacillus halodurans NYSGXRC-6131c SGX Pharmaceuticals 2004-05-26 active Selected Cloned Expressed Soluble Purified EC1196 ICEDB: T1882 GENBANK NP_294480.1 MTVSAAPVTPLSVTLALDTATPFLTLAVSWPGGELERVQEVGRASAERLADETRALFGAAGLPFQAQTIVIGTGPG SYTGVRVGASYALGLARVWGAEVRGVSTLESLVRGDGPQAVSLDARKGNVYSAVYEVSAGTVTDTVQPVARRPLA EFEAELSGLPHWRDPAPSGLALLRAGLAHGAKDWELAYL Deinococcus radiodurans NYSGXRC-6132a SGX Pharmaceuticals 2004-11-10 active Selected Cloned Expressed Soluble Purified EC339 ICEDB: T1690 GENBANK NP_418248.1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDR KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAE VTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELG WQDIKVADNADNDALLRALQ Escherichia coli NYSGXRC-6132b SGX Pharmaceuticals 2004-04-02 active Selected EC339 MDDRSPSPSSVPPDALPHPSAPVVIVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYAL VVFVSPNAVQQAFAAMPEGFRWPQDVPAAVVGPASAQALAAHGVAAPTYRVIRPDSHADDARQDSEALYARLDVA TLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDTAAWAALREVLAGRHAWTLTSSEAARNLDSL ARASLSAAEVEALYAAPCFAPHARIVEQAQSLGFRDVTLTGAGDDRLLAGVLAWAGPVALAAETTPSPAPVAAPA ESNPSSPAPTVSQTPVPTSVPTPGPAAASPGLAPAPAAPTMTAGAGPGRGGWLLWAALILALVVVAGLQIRNERL AREVRQRAQQNETLAQEMRVLSRNNQDAFAQLQQKFGALDARTAETRDRQGALEQASQDLLRNRDDWQRAEIERS LEVASEQLQLTGNVSGALATLQTIDARLATVDKPQFRAMRRAVARDIAKLKAMPAVDLSGAAIRLDDAINGIDAL PLVSSAAPLESGQAAPASRGRPAKPGKGAAPASAFAASPAAESGWSAGVRAWWSRLWHDVRSELGQIVQVRRVDQ TDALLLSSDQAWFLRENLKLWLMNARLALLSRNEAVFRADLGRADTLLARYFDTQSPRVVAEQTLLQQARASVGA LEVPTLGDSLAAARGQGKE Ralstonia solanacearum NYSGXRC-6132c SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC339 GENBANK NP_229778.1 LIESVMTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAEDLSSFDIIIAVSQHAVIFSDQFLQHR RICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISDSEHLLALSMLRDVAGKKVLILRGNGGRELIYSTLVERGA TVRYQEAYCRHERPFAAAECVQKWQLAKVDSLVITSSEQLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLG FHRIVVTLSAANRDLVAALMPEKPTGTLSNDQQQ Vibrio cholerae NYSGXRC-6133b SGX Pharmaceuticals 2004-05-17 active Selected Cloned Expressed EC2157 GENBANK NP_242295.1 VTNLHYTVKSLMRFKDKTVIISGGGNSAIDWANELEPIAKKVYLTYRKEALNGHEAQISQLLSSSATCLFHTTISK LIARDNKEVIEQVELTDHQTGEVTNLAVDEVIINHGYERDKSLLDQSEVTLDRIDDYYIAGTPTSATSVGGIYAA GDVLKHEGKLHLIAGAFQDAANAVNQAKQWIEPEAHQSAMVSSHNHVFKERNRELIRQMLKN Bacillus halodurans NYSGXRC-6133d SGX Pharmaceuticals 2004-12-01 active Selected Cloned Expressed Soluble Purified EC2157 ICEDB: T2204 GENBANK ZP_00231061.1 LPNEVYDVTIIGGGPIGLFSAFYSGLRSMKTKIIDAEPAVGGKVRYFFPEKIIRDIGGIPAITGENLVANLKQQAE TFHPTIVCSERVVDVTKLADGTFQLTSHNGSIHFSKTIVIATGSGTFEVNKLEALHAEDFPFAIHYDVKNIEQFR DKVVVVSGGGNSAIDWAQTLEPIAKKVHLIYRGEDFKAHEESVRELKNSRVEIHIHHEISELIGTNNQLTEITVC CNQTQTTKTIETEALFINHGVKVDLGTMAEWGFKQADFGIVVDDEMKTTVPGIFACGDSATYPRKIRIIAAGLHE GPIAINSAKKYLEPTAADEAMISTHHESFIG Listeria monocytogenes NYSGXRC-6134a SGX Pharmaceuticals 2004-11-10 active Selected Cloned Expressed Soluble Purified EC1603 ICEDB: T1737, T657 PFAM PF00696 MNVVVQKYGGSSVATPERIKNVAQRIKKKVDEGYKVVVVVSAMGKTTDNLIKLAKEISPRPDSRELDMLLATGEQV SAALLSMALKDLGVKAKSLNAFQVKIKTTPHHTSARIVDIDDSVIRENLKDYDVLVVTGFQGVNEHGDLTTLGRG GSDTSAVALAAKLRVPCEIYSDVDGIYTCDPRVHPRAKKLAYITYDEALELTALGAKVLHSRSVEIAKKYGIPIY CASSFTEEEGTMVVERLPEWLEEPVVTGATISHGQIKVSISFLPKDVKYITAIFEEVGKRALNVDMISLVPSNGK VFLSFTILEDHKEDLDEALKEALRDVEGWKSTYEGGFAKLSIVGVGMRTSPGVAARFFEALERAGVTPELVTTSE IKISCLVPEEKAEEALKSVIEEFEL Thermotoga maritima NYSGXRC-6134b SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC1603 GENBANK NP_249595.1 MALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQV TIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRG GSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPL RVLHSFQEGPGTLITIDDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAH DNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMIS TSEIKVSVVIEEKYLELAVRALHTAFELDAPARQGE Pseudomonas aeruginosa NYSGXRC-6134c SGX Pharmaceuticals 2004-03-08 active Selected Cloned Expressed Soluble Purified EC1603 ICEDB: T1686 GENBANK NP_243962.1 MSIIVQKYGGTSVGSVQRIEHVANRIIATAASGKKVVVVVSAMGKTTDELVGLASEITDEPRKREMDMLLATGEQV TIALLAMALHKRGQEATSLTGWQAGMITESHHGNARILEVERARMDELLDKVHVVIVAGFQGIDQQGEIMTLGRG GSDTSAVAIAAALKAERCEIYTDVTGVFTTDPRVVKQARKLQTISYDEMLEMANLGASVLHPRAVEFAKNYEIPL LVASSMVDEPGTMIEEEGTMEQNLLVRGIAFENDVTKVTVHGLPNEIHTLPTLFAHLSAAGINVDIIIQNQTDSG MAISFSITQSSLKETLARLEELKGELSFQGIDYEEELAKVSIVGSGMVSNPGVAAKMFEILAANDIAIKMVSTSE IKVSAVIDEELMVLAVEMLHEQFKLHEEEPAVAVKV Bacillus halodurans NYSGXRC-6134d SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC1603 GENBANK NP_356477.2 MVLVKAMARIVMKFGGTSVANLERIHNVARHVKREVDAGHEVAVVVSAMSGKTNELVDWVQNAAKVAGTNAASFYD AREYDAVVASGEQVTSGLLAITLQSMGINARSWQGWQIPIRTDNAHGAARILEIDGSDIVHRMGEGQVAVVAGFQ GIGPDNRIATLGRGGSDTSAVAIAAAVKADRCDIYTDVDGVYTTDPRIEPKARRMKKIAFEEMLEMASLGAKVLQ VRSVELAMVHKVRTFVRSSFEDPDAPGMGDLINPPGTLICDEDEIVEQEVVTGIAYAKDEAQISLRRVADRPGVS AAIFGPLAEAHINVDMIVQNISEDGSRTDMTFTVPSGDVAKALRVLDENKGQIGFDVAQNETGLAKVSVIGIGMR SHAGVAASAFKALAEKNINIKAITTSEIKISILIDGAYAELAVRTLHSAYGLDKA Agrobacterium tumefaciens NYSGXRC-6134e SGX Pharmaceuticals 2004-03-12 active Selected Cloned Expressed Soluble Purified EC1603 ICEDB: T1732 PFAM PF00696 LTEKCVIKIGGSVLKDGSSLPRVMDIISHFRSPILVVSAFGGITDALYRFYEYDESRMDKLRDLLLMHLGILWKYN IEAHPEISIQDSSILDQDAYVSYGEKMSAFTLARFLTGNGIPAAPIYTDEAGLIVEEISKERTVDLEGSRAFFEN IARVETSGKVPVVTGFFGIDRYGKTRILGRNSSDYSAVAVAAILGIREVILIKDVPGIYMNLEDRTSIVNRIDYE TALRIVDRGSKVVHRAALRLAMKMGMNLLITSPENLESGTVIGDLF Thermoplasma acidophilum NYSGXRC-6134f SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC1603 GENBANK NP_147738.2 VERLNKPSAPRYSRLREWVVGCAPNDLVVVKFGGSVLNGSPGFLAAGRLVLGLLESGLEPVVVVSAVKGVTDALLS SFERRDPGVGGAVGKTYLSIARELGLPPESVRDVSLASAEVSKLLWAAEVLGQWTPRVRDLVVSYGERLSAALMA GLLRRLGVEARWLGGGEAGIVTDGEFGDATPLYGYTEGVIRERLEPMLEEGVVPVVAGFTGATREGDTTLLGRGG SDLTATLLASALGAGRVVLYTDVPGILSGDPRVVGEPRRVGYMSYEEAWEVARLGLRKFHPRTFEPLIAGGLGVE VVVSDLRGRSTRIGPGRGGPPLKVVSLSRGVARLVVRGPSMAGKRGFLSRLAGLLAGRGVNILAIRQPPSETAIE LVVDERDLPAAVEELGARSGAAGVRLEVERGFDVVSIVGWGAVEALPEALSAAEKTGGRLLSTGELSPSISILAR GRTSPELARLLHRRVVESWVTG Aeropyrum pernix NYSGXRC-6135a SGX Pharmaceuticals 2005-10-26 active Selected Cloned Expressed Soluble Purified EC959 ICEDB: T1691 GENBANK NP_415296.1 MAHRPRWTLSQVTELFEKPLLDLLFEAQQVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQTSRYKTGLEAERLM EVEQVLESARKAKAAGSTRFCMGAAWKNPHERDMPYLEQMVQGVKAMGLEACMTLGTLSESQAQRLANAGLDYYN HNLDTSPEFYGNIITTRTYQERLDTLEKVRDAGIKVCSGGIVGLGETVKDRAGLLLQLANLPTPPESVPINMLVK VKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPEEDKD LQLFRKLGLNPQQTAVLAGDNEQQQRLEQALMTPDTDEYYNAAAL Escherichia coli NYSGXRC-6135b SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC959 ICEDB: T1717 MARHPRWTLSQVTELFEKPLLELLFEAQQIHRQHFDPQQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLM EVEQVLDSARKAKNAGSTRFCMGAAWKNPHERDMPYLEKIVQGVKAMGLETCMTLGMLNESQAQRLANAGLDYYN HNLDTSPEFYGNIITTRTYQERLDTLEKVREAGIKVCSGGIVGLGETVTDRAGLLLQLANLPTPPESVPINMLVK VKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPAEDKD LQLFRKLGLNPQQTRVLAGDNEQQQRLEQTLMTPDTDDYYNAAAL Salmonella typhi NYSGXRC-6135c SGX Pharmaceuticals 2004-06-04 active Selected Cloned Expressed Soluble Purified EC959 GENBANK NP_578579.1 VIRGWLAEGERMKETSYYSYVVGELPKGCQYCVRGEKLVLFVTGVCPRNCFYCPLSPWRRKDVAYANERPIRKIED IIEEAKIQEARGAGVTGGDPLARLNRTVEYIRTLKEEFGKKFHIHLYTTGILADKRALSMLYDAGLDEIRFHPDL FEPSSKFLNREIENLKNAFDFDWDVGGEVPAVPGFGDRIKWFAEILDKFGGKFLNINELEYSETNLSNILNRGFK LAGENSFAIKGSLELGLEILEWGEKNTSLYYHLCTAKLKDAVQLRNRLRRMAKNVAKPYMEITEDGTLRFGIAEY EDLEELYKFLVEEAEVPKEWLYINWEKKRIEMPVEVAEELAEAIEGDVKFYIVEEYPTWDRIEVERIPLN Pyrococcus furiosus NYSGXRC-6135d SGX Pharmaceuticals 2004-03-22 active Selected Cloned Expressed Soluble EC959 GENBANK NP_071141.1 MQNVESELKDIRLPYKTKSLCPECLKILEAEVYEENGKVMIRKVCEEHGEFVDVYWGDAEMFKKAARFAADGHGIS TPITQNTTCPFSCGLCNNHKSHTALLNIVLTNRCDLACWYCFFYARRAGYVYEPTIEQIREMVRKAKNMKPIGCN AVQLTGGEPTLRDDLIDIIRMIKEEGYDHIQLNTNGIRLAEDPDFALRVRVAGVNTVYLSFDGVDEKTNPKNHHE IPKILENCRRAQLGLVLVPTVIKGVNDHQLGDIIRFAAENIDIVRGVNFQPVSLVGSMPRKEREQFRITIPDCIK AIEEQTNGEIGREDFYPVPSVVPISRFVEALTGQPQYELTTHFACGMATYIFKDNGRLIPITRFVDVEGLFEFLN EKAEEIAKSRMKTIRAIKDIIDLRKFVDTSKAPKGFNIAKILYEVLIKHDYSTLGEFHVKSLFIGMMHFQDLYNY DIARVERCEIHYGSPDGRIIPFCTFNVIPERYRDAIHEKYGIPIEEWEKRTGRKLKDDIKRAVRRPR Archaeoglobus fulgidus NYSGXRC-6135e SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC959 ICEDB: T1722 MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVKLTGGEPTLRRDLVEIV RGLKQLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSRDTFKKITGVDAFDRVIEGIKSAIDVGLVPVK LNFVVNRRNREEAFKFIELSQNLGVNEIHLIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYV LPSGLIVEVVKPYANPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIRE PNFKYKI Sulfolobus solfataricus NYSGXRC-6136a SGX Pharmaceuticals 2004-03-02 active Selected Cloned Expressed Soluble EC2244 GENBANK NP_248478.1 VVAMITTVVGSYPVVKKEETFLDKVKKVFGLYDEYKYAIERAVKDQVKAGVNIISDGQVRGDMVEIFTNNMYGFDG KRVVGRVEFIKPITLKDILYAKSIAKKLNPNVEIKGIITGPCTIASSVRVESCYSDNRDENLIYDIAKALRKEVE ALKKHVPIIQIDEPILSTGMYDFDVARKAIDIIVDGLNIKFAMHVCGNVYNIIDELNKFNVDILDHEFASNKKNL VILESMEKKVGFGCVNTKVKKVESVEEIKSLIEEGIEILKNNEKLNKNLSDNILIDPDCGMRLLPIDVAFNKLKN MVEATKLIKI Methanococcus jannaschii NYSGXRC-6136b SGX Pharmaceuticals 2004-05-17 active Selected Cloned Expressed EC2244 GENBANK NP_142996.1 MELPILPTSVIGSYPKPRWLLRMYRLRDLGKIPEEDFKEAVKDASVSVLREHERAGVDIPWDGEMWRTEMTEHFTA KIGGFKFYGPVRVWGNAYFNKAAAVDKLEYKEPLVLEEFLWVKKNTTREVVKIPITGPYTIAEWSFNEYYPDKES FIMDLAKIINKELKMLENHGALYIQLDEPAMLNHPDEVPLAVEAINKAVKGIKIKVGLHVCYSNYYLLADYFDEI RVTQFALEFANRQFRDMDFLKKLSNKELGFGVVDVHNPRIESVEEIVKAIKKVFEYVEPELLYINPDCGMKLLDR NIAYNKLVNMVKATELVRKELEREGKKTTEFRTLKDI Pyrococcus horikoshii NYSGXRC-6137b SGX Pharmaceuticals 2004-05-26 active Selected Cloned Expressed Soluble Purified EC2473 ICEDB: T1910 GENBANK NP_579413.1 PFAM PF00696 MRVVKIGGSVISMLENLWRENGISEILGNSVIVHGGSRHVDELSRKMGVKIEKLTSPSGVTFRRTTKEVLKVYVAA MIRANKEIVEFLRNQGINAIGLTGLDRELIIGERKKLIKAVINGRVVAIRDDYSGVIKKVNTQILREYLKIGTPV IASIAYDPIENTPLNVDGDKVAYHVALAMDAKELYFLSDTAFMAGGKVVSELPADEIEKYLIFAKGGMKKKLLMA KEAINSGIKNVVIEGLNGRTVIY Pyrococcus furiosus NYSGXRC-6137c SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC2473 PFAM PF00696 VGGAEESSPETLAYGGRRALARYGVAVVKIGGSIASRLERVADEIAVLAREGLRLVVVHGGGKVVDEYSRRMGVEP RYVLHPSGVRSRYTSWEELEVYVMVMAGLLATSISSELASRGLKVLSLTGLDGLSVEARRRERIVIVNERGRPQA IPGGYTGKIERVDSMFVGSMLQQVDVILYSPVAYGREGDRVVALNVDGDQMAASLSAALKAPLALVTDVPGVILD GRVVDRIRVSEAREIAAKAGVGMNRKILMAAKAVSEGSPYAAIGDPPIQSLINGEKGTLVTRS Aeropyrum pernix NYSGXRC-6137d SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC2473 ICEDB: T1710 GENBANK NP_518154.1 PFAM PF00696 MTASVAAAPDPAGLDPELAHIAPALKAEILAQALPYIRKFHGKTIVIKYGGNAMTEEKLKHGFARDVILLKLVGMN PVVVHGGGPQIDDALKKVGKTGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVMLINQYGGQAVGLTGKDGGLIRA KKLKMPDREQPGQFIDIGFVGDIETINPAVVRALQDDAFIPVISPIGFSDDGQAYNINADVVAGKMAEILKAEKL VMMTNIPGVMDKQGNLLTDLSAREIDELFADGTISGGMLPKISSALDAAKSGVNSVHIIDGRIEHSLLLEILTEQ AFGTMIRSH Ralstonia solanacearum NYSGXRC-6137e SGX Pharmaceuticals 2004-03-05 active Selected Cloned Expressed Soluble Purified EC2473 ICEDB: T1705 GENBANK NP_274107.1 PFAM PF00696 MESENIISAADKARILAEALPYIRRFSGSVAVIKYGGNAMTEPALKEGFARDVVLLKLVGIHPVIVHGGGPQINAM LEKVGKKGEFVQGMRVTDKEAMDIVEMVLGGHVNKEIVSMINTYGGHAVGVSGRDDHFIKAKKLLIDTPEQNGVD IGQVGTVESIDTGLVKGLIERGCIPVVAPVGVGEKGEAFNINADLVAGKLAEELNAEKLLMMTNIAGVMDKTGNL LTKLTPKRIDELIADGTLYGGMLPKIASAVEAAVNGVKATHIIDGRLPNALLLEIFTDAGIGSMILGGGEDA Neisseria meningitidis NYSGXRC-6137f SGX Pharmaceuticals 2004-05-26 active Selected Cloned Expressed Soluble Purified EC2473 ICEDB: T1911 GENBANK NP_341712.1 PFAM PF00696 MIVVKIGGRVVKNSLDKIILDILNINDKVILVHGGGDIVTDYTKRLGIEPVFVTSPEGIRSRYTTKEELEVYIMAM SLINKSITSKLCSLGKNAIGITGVDGGLLLAERKKRIVVIDERGKKRIIEGGYTGKVKEVRSEIINHLVKLFDII VVSPIALDVEERTPLNIDGDQAAFAISKALRANVLILLSDVEGVLVEGKVINRLTPSEAKELSKKIGPGMNRKLL MAAESVENGVNKVIIGSGVKDRPIINALELNGTVIANG Sulfolobus solfataricus NYSGXRC-6137g SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC2473 MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLN NISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEP DYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASI KAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSW VKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRD AGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQ WVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYS TRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRK LEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCY ATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHV GQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCA TIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV Saccharomyces cerevisiae NYSGXRC-6138a SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC3032 MGMYKKLAIATLLYSADYLPGVFALGHQVNKLLEEAGKKGDIETCLIVTTSLFNGTLSELAKNILQSIYTKIVLVE PLNCQEESIQKNSENLALLERPELSFALIKARLWELTQFEQVLYLDSDTLPLNKEFLKLFDIMSKQTTSQVGAIA DIGWPDMFNSGVMMLIPDADTASVLQNYIFENTSIDGSDQGILNQFFNQNCCTDELVKDSFSREWVQLSFTYNVT IPNLGYQSSPAMNYFKPSIKLIHFIGKHKPWSLWSQKNFIKNEYHDQWNEVYEEFKEEHQLNNEVSKPKISDSDK TETPETITPVDAPPSNEPTTNQEIDTISTVEENVDNQNAEPVPNSDHSPAPNPVPLDFTKWLTTFINKDHLTNQP VNESREYSKENDNNIINSSSNRDQESPPNSTQELNSSYSVVSTQADSDEHQNAEEEDSTTDNASNSGEESHLDDI STAASSNNNVSNQPDGKNFSNSKENNISVESSPSNPEQKRSTDNIQKPSVSTNDLPDDVEPHTSVDDNIQYLEKD KEGYEEFLPDVYESNAIDNEEEFFDDDARDATEGETKTSAVADKQEDMKLTAEETNQPQQEMPNFKFDWEDSDYL SKVERCFPDDIFEYAVE Saccharomyces cerevisiae NYSGXRC-6139a SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC4903 ICEDB: T1714, T730 MTRPFNRVHLIVMDSVGIGEAPDAADFKDEGSHTLRHTLEGFDQTLPNLEKLGLGNIDKLPVVNAVEQPEAYYTKL SEASVGKDTMTGHWEIMGLNIMQPFKVYPNGFPEELIQQIEEMTGRKVVANKPASGTQIIDEWGEHQMKTGDLIV YTSADPVLQIAAHEDIIPLEELYDICEKVRELTKDPKYLIGRIIARPYVGEPGNFTRTSNRHDYALKPFGKTVLD HLKDGGYDVIAIGKINDIYDGEGVTEAVRTKSNMDGMDQLMKIVKKDFTGISFLNLVDFDALYGHRRDKPGYAQA IKDFDDRLPELFSNLKEDDLVIITADHGNDPTAPGTDHTREYIPVIMYSPKFKGGHALESDTTFSSIGATIADNF NVTLPEFGKSYLKELK Staphylococcus aureus NYSGXRC-6139b SGX Pharmaceuticals 2004-06-04 active Selected Cloned Expressed Soluble Purified EC4903 GENBANK NP_465478.1 MPDKFKRVHVVVMDSVGIGEAPDAAKFGDFDVDTFGHIAKHVGGLKMPEMGKLGLSNIREIEGIKKAEKPLAYYTK MQEASNGKDTMTGHWEIMGLYIDTPFRVFPDGFPDDLINQIEEKTGRKVIGNKPASGTEIMAELGEEHVKTGALI VYTSADSVLQIAAHEDVVPLEELYEICEFCRKITLDDPYMLGRIIARPFVGEPGAFVRTPNRHDYALKPFKPTVM DALKDGGKDVIAIGKISDIFDGEGVTESIRTKSNMDGMDQFIAVLDKDFNGMSFLNLVDFDALFGHRRDPQGYAD ALVDFDGRLVEVMEKLTDDDLLIITADHGNDPTYTGTDHTREFVPLLVYSPRFKNGGSELELRKTFADLGATVAD NFDVKMPEYGTSFLRDLK Listeria monocytogenes NYSGXRC-6139c SGX Pharmaceuticals 2004-05-26 active Selected Cloned Expressed Soluble Purified EC4903 ICEDB: T1860 GENBANK NP_813986.1 VFKRVHLIVLDSVGIGEAPDAEKFGDVGSDTLGHIAKEAGLTIPHLEKLGLGTIAPLTGVKAVADHDGYATKLEEI SVGKDTMTGHWEIMGLNIKKPFRVFPNGFPEELLKQIEDFSGRKVVCNKPYSGTAVIDDYGEHQMKTGDLIVYTS ADPVLQIAAHEDIIPLEELYKICQYVRDITKDEPYMIGRIIARPYVGEPGNFTRTSNRHDYALDPFGHTVLDSLK ENGNDVIAVGKINDIFNGQGITEAIRTKSNMDGVDQLLTVMNKEFTGLSFTNLVDFDALYGHRRDVKGYAKAIED FDGRLPEIMAAMAEDDLLLITADHGNDPTFPGTDHTREYVPLLAYSKKMTKQGSLPQGFYSDISATIAENFEVPA TENGQSFLNQLQ Enterococcus faecalis NYSGXRC-6139d SGX Pharmaceuticals 2004-03-17 active Selected Cloned Expressed Soluble Purified EC4903 ICEDB: T1728 MSKFNRIHLVVLDSVGIGAAPDADKFFNAGVADTDSDTLGHISEAAGLSVPNMAKIGLGNISRPIPLKTVPTEDNP TGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPR QMETGELIVYTSADPVLQIAAHEDIIPVEELYKICEYARSITLERPALLGRIIARPYVGDPGNFTRTANRHDYAV SPFQDTVLNKLADAGVPTYAVGKINDIFNGSGITNDMGHNKSNSHGIDTLIKTLQLPEFTKGFSFTNLVDFDANF GHRRDPEGYRDCLHEFDNRLPEIIANMKEDDLLLITADHGNDPTYAGTDHTREYIPLLAYSVSFTGNGLIPQGHF ADISATVAENFGVDTAMIGESFLSHLK Streptococcus pyogenes NYSGXRC-6139e SGX Pharmaceuticals 2004-03-11 active Selected Cloned Expressed Soluble Purified EC4903 LLDEMEFRFQLQKKENRRGHKMSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISKTVGLNVPNMAK IGLGNIPRETPLKTVAAESNPTGYATKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRK VIRETNKPYSGTAVIYDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIA RPYVGEPGNFTRTANRRDLAVSPFSPTVLDKLNEAGIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTLLKTM GLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMRENDLLLITADHGNDPTYAGTDHTREY IPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETAMIGESFLDKLV Streptococcus pneumoniae NYSGXRC-6139f SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC4903 ICEDB: T1718 MKRAFIMVLDSFGIGATEDADRFGDVGSDTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLVKAHEGSTGKIAAGM DGNADVIGAYAWAHELSSGKDTPSGHWEIAGVPVLFDWGYFSDHENSFPQELLDKLVKRANLPGYLGNCHSSGTV ILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTEGGYNIGRVIARPFIGDKAGNFQR TGNRHDLAVEPPAPTVLQKLVDEKQGHVVSVGKIADIYANCGITKKVKATGLDALFDATLKEMKEAGDKTIVFTN FVDFDSSWGHRRDIAGYAAGLELFDRRLPELMELVGEDDILILTADHGCDPSWTGTDHTREHIPVLIYGPKVKPG SLGHRETFADIGQTLATYFGTSPMDYGKNML Salmonella typhi NYSGXRC-6139g SGX Pharmaceuticals 2005-10-26 active Selected Cloned Expressed Soluble Purified EC4903 ICEDB: T1681 GENBANK NP_213380.1 MDVISELVKKNGSKILLIVLDGLGGLPVKEGKTELELAKTPNLDKLVKNSATGLHIPVDWGITPGSGPGHLGLFGY DPIKYQIGRGILEALGLGIDVKDTDIAVRGNYATVEYRNGKPIVVDRRAGRIPTEENKRITAKLQEAIKEIDGVQ VIIKPGMEHRLAIVFRFPEKLSPGSDAINDTDPQQVGKEPLEPKGENPNAEKVAEVVRKFIQRATEILRNEPKAN YILLRGFSQKPDIPTMEERFGVKPCCIAVYPMYKGLASLVGMDVIEFEGSTIQDEIDTLKKVWNEYDYFFVHIKK TDSYGEDGNYEGKVSVIEDFDAHLPQFLELKPDVLAITGDHSTPSILKGHSWHPVPLLIHSPYVLGGTSERFTER ECLKGELGIIPAVKITQLLLANALRLKKYGA Aquifex aeolicus NYSGXRC-6139h SGX Pharmaceuticals 2006-12-19 active Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data EC4903 ICEDB: T1738 MRVVLIVLDSVGIGEMPDAHLYGDEGSNTIVNTAKAVSGLHLPNMAKLGLGNLDDIPGVEPVKPAEGIYGKMMEKS PGKDTTTGHWEIAGVILKKPFDLFPEGFPKELIEEFERRTGRKVIGNKPASGTEIIKELGPIHEKTGALIVYTSA DSVFQIAAKKEIVPLEELYRYCEIARELLNEMGYKVARVIARPFTGEWPNYVRTPERKDFSLEPEGKTLLDVLTE NGIPVYGVGKIADIFAGRGVTENYKTKDNNDGIDKTISLMKEKNHDCLIFTNLVDFDTKYGHRNDPVSYAKALEE FDARLPEIMHNLNEDDVLFITADHGCDPTTPSTDHSREMVPLLGYGGRLKKDVYVGIRETFADLGQTIADIFGVP PLENGTSFKNLIWE Thermotoga maritima NYSGXRC-6140a SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC2605 MSTVQAIRTVLFYLLLSASAFVWGTLSFFIAPILPFRARYRFVVQNWCRFAIWLTRVVAGIRYEVRGLENIPEKPC VILSKHQSTWETFFLSGFFEPLSQVLKRELLYVPFFGWALALLKPIAIDRSQPKLALKQLAKQGDECLKKGAWVL IFPEGTRIPVGQMGKFSRGGTALAVNAGLPVLPIAHNAGQYWPKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAEL NQRAEAWVSETMAEISPIQQRVSHPEPSVVS Pseudomonas aeruginosa NYSGXRC-6140b SGX Pharmaceuticals 2004-12-01 active Selected Cloned Expressed Soluble EC2605 GENBANK NP_214410.1 MCPLTPVGKYLLLPLWLGVRPFFRALFRIEVIGKENIPEGACIVASNHRSHLDPPVLNAVFPEPLVFLAKEELFKP PFGGILKHMRAIPLRRGSEDISTLEECVSLLKLGCKIGIFPEGTRANPGEFKRAKPGVGFLAINSGFPVLPVYID GTDRAFPRGKKFPKPFVKVSVVIGKPLEFKGLEPSVKNYKRVANEIMEEIKKLAQSLHRK Aquifex aeolicus NYSGXRC-6140c SGX Pharmaceuticals 2004-05-17 active Selected Cloned Expressed EC2605 GENBANK NP_216698.1 MWYYLFKYIFMGPLFTLLGRPKVEGLEYIPSSGPAILASNHLAVADSFYLPLVVRRRIWFLAKSEYFTGTGLKGWI NRWFYSVSGQVPIDRTNADSAQGALQTAVVLLGQGKLLGMYPEGTRSPDGRLYKGKTGLARLALHTGVPVIPVAM IGTNVVNPPGRKMLRFGRVTVRFGKPMDFSRFEGLAGNHFIERAVTDEVIYELMGLSGQEYVDIYAASVKDGRNA GGAGANPNSTDAARIPETAAG Mycobacterium tuberculosis NYSGXRC-6140d SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC2605 GENBANK NP_518643.1 MTFVRSLLYLSFLIVWTPFYAVACFIAFPFMNPHRRFWMVTGWTKSAIWVARWLLGIRWQCQGWEHIEEAVATNKQ VVLLSKHQSAWETIAFVAIMPRPLCYVFKRELLYVPFFGWALGMLKMVHINRKDGTNAFASVARQGKERMADGSW IIMFPEGTRTPVGAPNPRYKSGGARLAVDTGAWVIPIAHNSGRLWPRNAFLKYPGLITLSIGPAISSAGKSGDQL NREVQAWIEAEMRRIDADSYRERA Ralstonia solanacearum NYSGXRC-6140e SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC2605 MLWSMTDGATPATPPTAAPEERFPHVNPLVYRFVVDVTFLPVLLTGMHIDVHGREHVPPPGTPLVVAANHQSALDP FLIARALPPGRYLQFMAKRELFVPVIGDIIRAGGSFPVDRESNDVGAIRTSLRILKAGGTVGIFPQGTRGGQELH GGAALIAARGRAPILPAGISHDGKRWVVRFGEPLPARGGIKANTEELGRRLQVLAQPVGRHL Deinococcus radiodurans NYSGXRC-6140f SGX Pharmaceuticals 2004-01-26 active Selected Cloned EC2605 MKGHPSMRSVLFNAYYWVLSIFYGLSAAFAALAPGREAVTFTLRLYSRRMLWALDTLAGVKVQVKGKENLPAGPCI IAAKHHSWGDGFVMFAHVDSLSFVTGDHLEKFPLVGTILKKFGAIVVDSCGGPEAREALSKSAAQVAAEGRRILI YPEGHLAAPGEHFRYRTGVYYMSKDFGLPVVPVATNLGCFWQQTEKKKTPGMATIEFLPALPQGLEKDDFMKLMQ ATIEGRTNELIAEARGEAVKPSVLVEPGGKKTASAPAEPAAASLLP Caulobacter crescentus NYSGXRC-6140g SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2605 GENBANK NP_275025.1 MLIIRNLIYWLILCSTLIFLFPFMLLASPFRDGAHKMARVWVGILNWSLKHIVGLKYRIIGAENIPDRPAVICAKH QSGWETLALQDIFPPQVYVAKRELFKIPFFGWGLKLVKTIGIDRNNRREANEQLIKQGLVRKNEGYWITIFPEGT RLAPGKRGKYKLGGARMAKMFEMDIVPVALNSGEFWPKNSFLKYPGEITVVICPTIPHASGSEAELMEKCEHLIE TQQPLISGAGPFAAKMPSETA Neisseria meningitidis NYSGXRC-6140h SGX Pharmaceuticals 2004-06-01 active Selected Cloned Expressed Soluble EC2605 GENBANK NP_905433.1 MLWSRCTLFLFLCPIRVRGREHIPGKGPFVVMANHQGACDIFMMYGYLGIPFKWVLKEGIRKLPFVGYACRSAGFV FVDDTRPSSIAHTMDQAKRVLAEGTSIFIFPEGSRTRNGRLARFKKGGFLMADELGVPIIPVSLDGSYRVLPSGK LIPRPHRLTLTIHPPLSVADFGERPLCISEAVRETSRRIASVLPEEMAATQSK Porphyromonas gingivalis NYSGXRC-6141a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3719 MVVVGKSEVRNVSMSRPKKKSLIAILSTCVLFFLVFIIGAKFQYVSVFSKFLDDRGDNESLQLLNDIEFTRLGLTP REPVIIKDVKTGKERKLHGRFLHITDIHPDPYYVEGSSIDAVCHTGKPSKKKDVAPKFGKAMSGCDSPVILMEET LRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTELFSAGNEEDPRDFDVSVIPSLGNND VFPHNMFALGPTLQTREYYRIWKNFVPQQQQRTFDRSASFLTEVIPGKLAVLSINTLYLFKANPLVDNCNSKKEP GYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAKNFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHFIPTDGKKA RKSLLKAMEQSTRVQQGEDSNEEDEETELNRILDHAMAAKEVFLMGAKPSNKEAYMNTVRDTYYRKVWNKLERVD EKNVENEKKKKEKKDKKKKKPITRKELIERYSIVNIGGSVIPTFNPSFRIWEYNITDIVNDSNFAVSEYKPWDEF FESLNKIMEDSLLEDEMDSSNIEVGINREKMGEKKNKKKKKNDKTMPIEMPDKYELGPAYVPQLFTPTRFVQFYA DLEKINQELHNSFVESKDIFRYEIEYTSDEKPYSMDSLTVGSYLDLAGRLYENKPAWEKYVEWSFASSGYKDD Saccharomyces cerevisiae NYSGXRC-6141b SGX Pharmaceuticals 2004-01-26 active Selected EC3719 MRPSVITVAVLFVQSTWASFAFGNPMSMRNKAHTNDLVNSKGKPLVGRFLHITDMHPDIYYEKGSTVDHYCHSYDH NSDDTPLGKSKVGYLSPGPGYECDSSPALIDKTLEWLKEHQDDVLGGIDFILWTGDNSRHDNDNHFPRTQSEILA SNEDLVNKMIEAFPDVPIVSAIGNNDIYPHNIMEAGPSSMTRQLAGAWDALIPYEERHTFEKGSYYLCDVIPDKL AAISINTLYLSNKNAAVDGCPDDNLDEPGSLFMRWFKIQLEAYRLKGMKVWLLGHIPPTRGQWYEDCYTSFTDLL YEFRDIIVGQLYGHMNINHFVFLEFDKLPVDTESYGIKSAQPKYVKSLIDAQYAELPTFPENLTEEFLNGTVGNY SLATVGGSIIPEMFPTFRVYEYNISDIANQLDDREELTEITSFNWETLEEQSQSDYEIDKKKKKKKKNNKKKKKN KRKNIKPGPLGPAYVPSLFTPISFKQYFLNTSNYMDATKDTEISYELLYTSKDSPYNMPDLTVPEYMRLAKRIAT CDKPEDPHQFKLQSGDQNTFRISKKKKPSICPIAYTYLWHAYIGSISDFED Schizosaccharomyces pombe NYSGXRC-6142a SGX Pharmaceuticals 2004-03-22 active Selected Cloned Expressed Soluble EC550 GENBANK NP_390973.1 LKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKYSQIPEPWKKRMKKQAECTVAVGWRQQYCGIEH MAENDVNYYFIDNEYYFNRDSLYGHYDDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHP FYERMKSVLTIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTYRNEIMTPY YGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLENKTKLQQRMGLPEKNDIPLISMVTR LTKQKGLDLVRRIMHELLEEQDIQLVVLGTGEREFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPS KFEPCGLGQLIALQYGAIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSIV KTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE Bacillus subtilis NYSGXRC-6142b SGX Pharmaceuticals 2004-02-25 active Selected Cloned Expressed Soluble EC550 GENBANK NP_213495.1 VRVLFCSSEIYPYAKTGGLADFSFCLIKYLKKYGVKVKGVMPYYKTLKAENLRKTDKGVTLNLNGKDYTFEVYESE DCYFLRNDELFGRDYIYGPPGWGYEDNDIRFGGFSRAVSELISTGQLEADVVHANDWQTALIPLFLKEVFKTPVK TVFTIHNLAYQGLFPKETVERVGIPPYLFHMEAVEFWGLVNFMKGGIVFSDLITTVSPTYAKEIQTQEYGYGLEG VLKKYSYKLRGILNGIDYEVWNPEKDKYIYQNYSLRNYSKKFKNKEFLSKELGIEAEKPLISFINRFTHQKGVEL ILNCAEEMSKLNANFVFLGTGEYENAFLDVSKIYKNFKVFAEFNEGFARKLYASSDFILMPSYFEPCGLTQMIGM RYGCVPIVRKTGGLRDTVKDISEGGYGITFEEPSKETFLCSLKRAIELYENAKKFRNSVKIVMSLDFSCDRMTKE YIECYEEVQSHQ Aquifex aeolicus NYSGXRC-6142c SGX Pharmaceuticals 2004-03-09 active Selected Cloned Expressed Soluble Purified EC550 ICEDB: T1707 MDSKKILYISQEIFPYLPETDISVVSRKLPQTIQERGNEVRIFMPRYGIINERRNQLHEVIRLSGINMIINDNDHP LIIKVASIQSARMQVYFIDNDDFFKRKTMYDIKPKQENDNDERAIFFVRGALEAIKKLRWIPDVIHCHGWFTALA ALYLKKMYADDPCLQKAKVVYSVYDDAGQGVIPETLFGKLGFDKITPDDLSVMEQSSDYLALNRLAIRYADGVIQ GSETIAPELTDYISSLEGKAFLPYQGKEDYEEAFDNFYSDLLTAN Porphyromonas gingivalis NYSGXRC-6142d SGX Pharmaceuticals 2004-02-20 active Selected Cloned Expressed EC550 GENBANK NP_348856.1 LKILFASSESYPFIKTGGLGDVSYALPKALRKIGIDARVIIPKYSDIPEYFRYNTHHIASFGVPVGWRSQYGGLEY YEYDGVPFYFIDNDYYFKRSGLYGYYDDGERFAYFSRGVLQAITYMQDFNPDIIQCNDWQTAIIPVLLKDHYRNY RNYNHIKTIFTIHNLKYQGVFGKSVLGELLCLNEGYYNENALKFYDGISFMKGGILFSDKLSTVSRTYAEEIKDP YYGEHLDGLLRSRSYDLWGIVNGIDYDILNPETDKDLFFNFDSSTLYNKTKNKIELQKMLNLPVSENIPMIGIVS RLVSQKGLDLISCVLEDLLQDGIQLVVLGTGDAKYENMFKYFAWKYPNKLSANIQFNNSLAQKIYGASDMFLMPS KFEPCGIGQLIALRYGSLPIVRETGGLKDTVRPFNPITGEGNGFSFTNYNAHDMLHVIRNAEYFYYNEKYNWNKL VQTAMNDDNSWSKSAEIYRNLYMSVL Clostridium acetobutylicum NYSGXRC-6142e SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC550 LSLNVLFVASEAVPLAKTGGLGDMVGACAGALQRAGLHVTVMLPGYPAAQAQLRDARVACALPDLPGGPARVLLGA MPDTGVPVLLLDAPALFDRPGNPYLDACGEPYADNALRFAAFSHAAAHVAGGVPDLPAFDIVQAHDWHAALVPLL VKRAGRPVKTVLTVHNLAFQGNFPPRIAQDLGLPPEAVREAGFFGQFSFLKAGLMWADRITTVSRTYAREILTDA FGYGMQDVLRARRHDLVAILNGIDNAVWNPSKDAYLSRPFFAGNLSGKHAAKLQLQTLLRLPKDAHAPLLALGSR LTHQKMADVALQALPQMLEAHPDLQVAVLGCGERRYESAMAALAERHPRRMAAVIGYTERNAHMLHAGADLLLHG SRFEPCGLTPLYAMRYGTVPVASRVGGLVDTIADRGSPEAALRGATGFLFDGETPEAMAGAVARALRVFVQPRAW RVLQYNGMTTDFGWSQPASEYLALYATLAPRATPMPHLQHWPMRTLARPASPPDTAPVGKPARRRRTTALSTTAR AHPVARAAGREKIRA Ralstonia solanacearum NYSGXRC-6142f SGX Pharmaceuticals 2004-03-26 active Selected Cloned Expressed Soluble Purified EC550 ICEDB: T1740 GENBANK NP_231362.1 MEQFNVWFTVSEVQGLVKSGGLADVAKALPQALKALHQQVAIALPAYRSVPGKEDAELVLETELTHWPHTQYRVLK RDLDGVPIYLIDCPAYFDRPALYAENNQAYADNGERFGFFSAACLDVLPKLGIQPDIIHANDWHTGLVPFLLKTR YRYDSFFEQVKSVLTVHNAIFKGIFSYHQLEVIPELNLSGMEFLQYGHDHVSMLRAGIAFADKVNAVSPNYAAEL LTPLGAHGLVDDFVRRARDLHGIVNGCDYSEWNPRTDHYLPATYSDEPESMRKGKALCKTALQEELHLPVTDVPL FGMVCRLTHQKGFHYLLPILEQFLRNNVQVVIVGTGEPEVAARLNKIAHYHRAKFAFVETYSERLAHWVEAGSDF FLMPSEFEACGLNQIYSMAYGTLPIVREVGGLKDTVNDYDKFPERATGFGYQEPTPEALLITMQRALLFYLQQPE EMLKVQQRAMQQNFSWEESAQEYMKMYRLARFG Vibrio cholerae NYSGXRC-6142g SGX Pharmaceuticals 2004-03-03 active Selected Cloned Expressed Soluble Purified EC550 ICEDB: T1698 GENBANK NP_439511.1 MKILHVCSELYPLLKTGGLADVLGALPQAQNQIGLDARFLLPAYPAITTGIPNTQVVAEFDNFAGHVVLRYGEYNG VGIYLIDAPHLYGREGNPYHDAYYNDYGDNYKRFALLGWVGAELATGLDSWWRAEVVHAHDWHAGLCVAYLFNKG KPAKSVFTIHNLAYQGQFSYHHLYEIGLPTGMFHVEGLELFGQISYLKSGLFYSDASTAVSPTYAQEITTPEFAY GLQGLLSGLKAQGRLVGILNGVDENIWHPNVDQYIPHHYKLKYMAGKKKNKAELQAYFNLPQDESALAFVMVTRL TEQKGVDLLIESADEIVKQGGQLMILGSGAPHLEQGIRELAERYPQNIAVKIGYDEALSHLMVAGGDVILVPSRF EPCGLTQLYGLQYGTLPLVRKTGGLADTVVDSTSESIKARTATGFVFESATPEALRHCLQRAFALWQKPRAWAMV RTDAMEQDFSWRKAAEQYRTLYERL Haemophilus influenzae NYSGXRC-6142h SGX Pharmaceuticals 2004-04-02 active Selected Cloned EC550 MRILAVTAEMFPFVKTGGLADATSALPQALERKGADVRTLLPLYRGLTPLVRGRKPVLVANILEQPVSVYYVVSDG HKLLLLEAASLFDRDGHPYGVKGEPFADNDLRFAVLSKVAAEIALGAIDGWQPDVVHVHDWHAALTCVYLADSTP SVASVLTLHNLAFQGQYPLERAGMLGLPSHLCTVDCLEYYDDMSFLKGGLTTASAVTTVSPTYAREILTPEMGMG MHGVLARRRGDLRGIVNGVDHDVWNPATDPYILANFTAATATRRSLNKYALLQALGLAPTQGPVFGVVSRLTWQK GIDLLPHVVPLIIERKGRLIVHGEGDTALEDSLQALAKRYPELVCAHIGYDERLAHMIQAGSDFIIQPSRFEPCG LTQLYALRYGALPIVSRTGGLAETIIDANDAAIEAGVATGFQFEPANEDDLRAALERAISAYNDRELFRRLQTQA MQANFSWDKSAAQYMALFESLVGNSTRETDAVADIRTETFAKIRADRRLAGTPGSPTG Agrobacterium tumefaciens NYSGXRC-6142i SGX Pharmaceuticals 2004-12-09 active Selected Cloned Expressed Soluble Purified EC550 ICEDB: T1721 GENBANK NP_721880.1 MKILFVAAEGAPFAKTGGLGDVIGALPKSLVKNNNEVSVILPYYDVVDAKFGDQIEDLFYFFTNVGWRREYVGIKH IFRDGVDFYFIDNKHYFYRGQIYGEFDDGERFAYFQLAALEAMEKIQFIPDILHVHDYHTAMIPYLLKEKYHWIN AYHGIKTVFTIHNIEFQGQFNPSMLGELFGVGDERYRDGTLRWNDCLNWMKAAVLYADRVTTVSPSYAKEIMTPE FGKGLDQIMRMESGKLSGVVNGIDTDLFDPETDPHLAVHFSKDDLSGKAKNKAALQERVGLPVREDVPLVGIVSR LTDQKGFQLVVDQLNTMMQLDLQIVLLGTGYADFENAFAWFGHAYPDKMSANITFDLELAQQIYAASDIFLMPSA FEPCGLSQMMAMRYGTLPLVHEVGGLRDTVIPYNEFEKTGTGFGFQDFSGYWLTKTLEAALDVYYNRKEDWKILQ KNAMTTDFSWDTASQSYEHLYKELA Streptococcus mutans NYSGXRC-6143a SGX Pharmaceuticals 2004-04-02 active Selected EC2660 MSFLNLPVRTLVAACGLSLLSLAAHADSFRGDAHAPQQAAVATPHPAATVAGLETLANGGNAFDAAAAIAAALAVA EPYGSGLGGGGFFLLRQAGAQPTYRFLDARERAPKAAYADMYRRNGKVDPRLSVDGPLAAAIPGLPAALVELSSR YGRKPLADNLVPAIRLAVDGVSVDRIYRDRAAMRLEAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGR YGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERRPLEVKLANGRELISAPPPSAGGVALAQSLQMLEQL PWQKAEPVQRAHYVLEVLRRAYRDRGLLGDPDFVANPLPSLLAPDYLKRLAAGIDPRRATPSSALPEAPAWREGD HTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPDTGVVLNNEMDDFAADTQGANSYGLAGSQANAVAAGKRPLSSM SPSFLESPTDFAAFGTPGGSRIPSMVLISMLQYFDGRPVGQWVAAPRYHHQYKPDVVEYEPRAFSDAEAAELRRR GYQLKRLERSYGNQQVLYWDKRSGRVDAASDPRGIGYSSLSLEAQAQPRPH Pseudomonas aeruginosa NYSGXRC-6143b SGX Pharmaceuticals 2004-01-26 active Selected EC2660 MSPTDTTPLLYSWDDQSRHQDPDWHKLRNYHGAWYRRISRRRFSQFIFAFGLMTLFVLVYSISSNLHTPTQFTGHK VRGRRGAVASEVPVCSDIGVSMLADGGNAVDAAIASTFCIGVVNFFSSGIGGGGFMLIKHPNETAQSLTFREIAP GNVSKHMFDKNPMLAQVGPLSIAIPGELAGLYEAWKSHGLLDWSKLLEPNVKLAREGFPVTRAMERVLKLPEMAH LLKDPIWQPILMPNGKVLRAGDKMFRPAYAKTLEIIANKGIEPFYRGELTNSMVKFIQDNGGIVTVEDFGNYSTV FADALHTSYRGHDVYTCTLPTSGPALIEGLNILDGYPLNTPSLAFPKRLHLEVEAMKWLSAGRTQFGDPDFLPLD HLDVVSKLLSKEFASQIRNNISLSKTYPWEHYNPSYDLPISHGTTHVSTVDSNNLAVSITSTVNLLFGSQLMDPV TGVVFNDQMDDFSIPGASNAFNLSPSPWNFIEPFKRPQSSSAPTILTDINGDFEMALGASGGSRIVTAVLDSIIK RIDMDYDIESMVASARPHHQLLPDILILESGFSKSVATRMKKYGHKVWRLKQHDTPLSQIQAVTRHHSEYYGMSD PRKYGQAAAY Schizosaccharomyces pombe NYSGXRC-6143c SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2660 GENBANK NP_344523.1 MPSAVGKKVVTTQNYIASYVGAKVLEEGGNAFDAAIAISATLSVVIPHTSGLGGDGFLLAKTPEGLIAYNASGWAP KELKVDKINSDRGPLTVVVPGLVDLWEFIYENYASKSLHELLIPAISLATNGFMVGRGLHHAIISSFKLSDDWNR VYGSKRFGDEIKLRGIAKVLKEISKDPRSFYEGKIAEELTKGLRERGVPVSYEDFSEFHGEIINPIKMKYKDFML YELPPNTQGLTTLELLKMIEVTEINKLPFNDVRRVNDHVRLSALAYADRNNYIADPRFVNVPVEMLLSEKYIANK IAEYGFEVKVNVTGDTTFFAVADGENEIGFIQSLFYPFGSGIVVNDIPFNNRGAGFSEGNNKPEPRKRPLHTLSI LMAEKDDERIFIGCAGGDLRPQIHAEVFEYYADYNMEIDEAVQAPRFMYLGNKVIAEKRLGVPATQTDYYSPEVG IVQALKYKKGRYIGVADIRSEGIVLPI Sulfolobus solfataricus NYSGXRC-6144a SGX Pharmaceuticals 2004-03-29 active Selected EC3374 GENBANK NP_346085.1 MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGILAKLKLDAVTVACGFL HDVVEDTDATLDDLEREFGPDVRMIVDGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRT LKHLRKDKQERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLE EYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYIA NRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQAD DAKEFVDSVKENYLAEEIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVEI IANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSY KTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGLL VRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQENYEQRLLDVEWEDQYPSSNKEYMAHIDIYGLNRTGL LNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG Streptococcus pneumoniae NYSGXRC-6144b SGX Pharmaceuticals 2004-03-29 active Selected Cloned EC3374 GENBANK NP_722338.1 MAKDANLTGQEVIDICSMYMNKADIAFVQKALDYATECHSGQFRKSGEPYIIHPIQVAGILADLHLDAITVSCGFL HDVIEDTEATLDHLEAKFGSDVKNIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRT LRHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNEVEFYKISHLMNEKRREREALVDDIVDKIK AYTAEQGLHGEIYGRPKHIYSIYRKMRDKKKRFDQIYDLIAIRCILDTQSDVYAMLGYIHELWRPMPGRFKDYIA NPKANGYQSIHTTVYGPKGPIEVQIRTHEMHQVAEYGVAAHWAYKKGIKGKVNSQESALGMNWIKELVELQDASN GNAVDFVDSVKEDIFAERIYVFTPNGAVQELPKDSGPIDFAYAIHTQVGEKATGAKVNGRMVPLTAKLKTGDVVE IITNSNSFGPSRDWINIVKTNKARNKIRQFFKNQDKELSITKGRDLLVDYFQEQGYVANKYLDRKHIEAVLNRLN YRNEGALYAAVGFGELSPVTVFNKLTEKERREQERAKAKAEAEELMKGGEVKHDNKKEVLKVKSEGGVIVQGSSG LLMRIAKCCNPVPGDPIEGYITKGRGVAIHRADCHNIKSQEGYEERLIDVEWEDDYSTKEYMAEIDIYGLNRAGL LNDVLQILSNQTKNISTVNAQPTKDMKFANIHVTFGIPNLTVLTAVVDKIKVIPDVYSVKRTNG Streptococcus mutans NYSGXRC-6144c SGX Pharmaceuticals 2004-03-29 active Selected EC3374 LYLFDSLKDVAQEYLTEPQIEALRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMRLDLETLQAALLHDVIE DCDVTKEDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFRKMVLAMVQDIRVILIKLADRTPNMRTLGALR PDKKRRIARETLEIYAPLAHRLGIHNIKTELEELGFEALYPNRYRVLKEVVKAARGNRKEMIQRIHSEIEGRLQE VGLPARVVGREKNLFSIYNKMKTKEQRFHTIMDIYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKAN GYQSLHTSMVGPHGVPVEVQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWMQSLLELQQSAGNSFEF IENVKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGNTCVGARVDRTPYPLSQSLKSGQTVEIISAPG ARPNAAWLNYVVTSRARTKIRQVLKTMRREDSITLGRRLLNHALGEHSVNEIAPENISKVLSDLKIASMDDLLAA IGLGELMSIVIARRLLGNADELTEPSKSGGNKNKLPIRGAEGILLTFANCCHPIPDDHIIAHVSPGRGLVVHRET CPNVRGYQKEPDKYMAVEWTKDYDQEFITELKVDMHNRQGALAELTNVISKTGSNIHGLSTEERDGRLYTVTVLL TTKDRVHLAGIMRKIRTMPHALKVRRRKN Vibrio cholerae NYSGXRC-6144d SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC3374 LKPIDEELLLEQLIDNVKNCKDLEAAKALLFEICGHDAILEKAVDYCIFCHEGQFRKSGEPYAVHPILVATLVGFL SENKSNILAALLHDVIEDTNCTEEELREQFGSEVLKLVLGLTKIIEIREDNLISSKSKKSLTKSALTFRNMLLAS IEDVGVLIVKLCDRLHNMLTLDILREDKQKRISEETLVVYAPIAHRLGISSIKNYLEDLSFKYLMPDEYKLIDNY INSNNQEMQLGLNEFISKIELLFLSNGFRQGSFEIQKRIKHSYSIYLKMQRKGIGIEEVLDLLGVRILVEKVSDC YLALGILHTHFNPLVSRFKDYIALPKQNGYQTIHTTLFDAKSIIEAQIRTFDMHKIAEFGIAAHWKYKEDGSVVA PRLDWLTDISMQSINNLENAEDYNAIELYEYAKDSLYVEDVAVYSPKGEIFTLPRGATVLDFAYEVHTKVGLHAK SAYVNRIKVPLLTELKNGDIVRVVTSNDKFYRCSWIDSVKTGKAKASIREFCKQKIREINLASSINMLSFIFGVD KNRIETWIEKENLVRRIRQVATDSAYLKDIVNGLKKYAKKSYWFDKYEIKEQKIGNFTLYCNHKIANVDFDFCCH PKRGDAVLAFVKGGNAIVHHKLCDRADKMIDNNQDMVFIKWDSNIPKSYKLIFSLENKKGVLAEFLAFLAKMQIN LLTINLSSDLNSAVDYFEITMEIPDNINPDSVKDRLKSRCKILDFTSLNDAYKES Campylobacter jejuni NYSGXRC-6145a SGX Pharmaceuticals 2004-05-18 active Selected Cloned Expressed Soluble Purified EC126 GENBANK NP_010329.1 MPAPQDPRNLPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNVSVVYG QLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWF GGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILN MVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASW LYNHHPAPGSREAKLLEVTTKPREWVK Saccharomyces cerevisiae NYSGXRC-6145b SGX Pharmaceuticals 2004-03-28 active Selected Cloned Expressed EC126 GENBANK NP_485400.1 MGRHSDNSLQESANHTVLLTSPTNTIPKDSRQRSQQFMQNLQDEICTALEQLDGKASFHQDHWERAEGGEGRTRVI REGRVFEQGGVNFSAVWGNSLPASILAQRPEAAGHEFFATGTSMVLHPRNPYVPTVHLNYRYFEAGPIWWFGGGA DLTPYYAFKEDAVHFHQTLKNACDVHNPEYYPTFKRWCDEYFYLRHREEQRGIGGIFFDYQDASGKLYVESQTDS SVAIYSQKVGNVARNWEDIFAFVQSCGQAFLPAYLPIVERRQGIEYGDRQRNFQLYRRGRYVEFNLVYDRGTVFG LQTKGRTESILMSLPPLARWEYCYEPEAGSPEAELTEVFLQPRDWV Nostoc sp. NYSGXRC-6145c SGX Pharmaceuticals 2004-03-28 active Selected Cloned EC126 GENBANK NP_520313.1 MDTQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERGGVGFSHVMGDTLPPSA TANRPELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQRPDAEPVWWFGGGMDLTPYYGFAEDAAHFHRTCK QALEPFGEELYPRFKQWCDDYFYLKHRKEARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATP YGERERAFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARDW V Ralstonia solanacearum NYSGXRC-6146a SGX Pharmaceuticals 2004-03-27 active Selected Cloned EC449 GENBANK NP_010231.1 MSVIGRFLYYLRSVLVVLALAGCGFYGVIASILCTLIGKQHLAQWITARCFYHVMKLMLGLDVKVVGEENLAKKPY IMIANHQSTLDIFMLGRIFPPGCTVTAKKSLKYVPFLGWFMALSGTYFLDRSKRQEAIDTLNKGLENVKKNKRAL WVFPEGTRSYTSELTMLPFKKGAFHLAQQGKIPIVPVVVSNTSTLVSPKYGVFNRGCMIVRILKPISTENLTKDK IGEFAEKVRDQMVDTLKEIGYSPAINDTTLPPQAIEYAALQHDKKVNKKIKNEPVPSVSISNDVNTHNEGSSVKK MH Saccharomyces cerevisiae NYSGXRC-6146b SGX Pharmaceuticals 2004-01-19 active Selected EC449 VRKIRNLLLTLYFYFIATVYIVFYGGFVLFRSFLMRDREKARKYVLKEIEKFGKRAFTWLFSDVVVEGSENIPKDR NFIVVANHQSLMDIPLILGFVATGAFIAKEELRKIPGVNWYIRYLNGVFLDRKNPRRAVRALREAIEKLKNGVTF IVFPEGTRSPDGKVLSFKKDSLMIAVKTGVPVLPVSIWGTYHLIPKGRWTFTPGKVFLKIHEPVDPKGFSSEEEL RKYVEEVVKRGVEELKARWSK Thermotoga maritima NYSGXRC-6146c SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC449 MVSPVVARIIELLPDSCVGFIGKRILNMYLNKYADINVHGMENLKGIDKPIMFIGNHLSNSDGLVLNKVLKDYDVT FVAGVKLKGDAITNLGTYCVKTTEIKPNTADKDGIYRVIDILKSNHNILMFPEGTRSRTGAMIEAKRGPLFIAKL SKAIIVPVGICGSEKLLPINKEGNMSNENFHHAKVEVNIGKPFYFDKRMKEESKKDYEKRALDNAMYKIAELIPE NYRGVYSDIKKVL Clostridium acetobutylicum NYSGXRC-6146d SGX Pharmaceuticals 2004-03-29 active Selected Cloned EC449 GENBANK NP_484285.1 MSRTREPLISLALYHAFKWSVVSPMLHTYFRGRIYGVENVPQSGPVVVVSNHASYFDPPIVSNCVRRPVAYMAKQE LFEIPVLAQAIKLYGAYPVSRGSADRNAIRAALEYLENGWAVGVFMEGTRTPDGRISDPKRGAALLAAKAKAPIL PVCLWGSENILQKGSSVPRAVPLTVRIGNLIDTPSSTNKDELESITQKCAAAINQMHDLGR Nostoc sp. NYSGXRC-6146e SGX Pharmaceuticals 2004-04-07 active Selected Cloned Expressed Soluble EC449 MEFLRDFGKTALIHQGNEISYAELLENIASFANLMDITPNERVGIVMENRPEWVYAFYGTWKKGGIVVPIDFMSTP QEIRYILEDAEPSIIFCSDETYPRVREASEDLKVEIVNVDNLVLPTPWEGIVRRDEDDVAVLPYTSGTTGNPKGV MLTFKNLMSNIRGVSEVGIAGKEDKTLAILPFHHMYPLMTTMLLPLYLGATVVFLDKLTPEDIIEKLQKYQITVL IGVPRLYQLFHRRIMEEINKNVLAKNLFKLMKKVKNQKIRKTVFKKVHDAFGGRIKYMVSGGAKLPLDIAQDLTT LGFTVIEGYGLTETSPIVSFNPPNRIKLGSVGVPIKGVEVMTTSEGEIIVRGDNVMKGYWKKPEETQKVIINGWF YTGDLGEIDEEGYIYITGRKKEIIVLGSGKNVFPEEIESKILAKAPYIKEVGVFEKDGKLLALIYPDFEKVKELG ITNLEETIKWEVIDKVNRELPEWKRVVGFKIVKTELPKTRLGKLRRFLLPQIYEKAEEIKEEKTEDYSVFETEEG RIIKEFLEKISQKEVKPGDHLEIDLGLDSLAKVELLGFIETNFGVSLSEEELSKNLVVKDLIELVRSKKKSVDTK EVSWKDILTKAKPYELYHYPLIFELGRKLLKLYFKLYHRIDVRGLENLPKPPFIIAPNHQSYLDAFAIAAVLPKE IAHETYFLGDETYFRNPITSTFGKLAHVITVNVNKGLKESLQKTAYALMSGKVVVIFPEGARTRTEELMEFKKGV AILARELGVPIVPVAIEGAYEAWSVYDKFPKPKKIKIMFGKPVDPDEKSYEEITKELYEWIKSMLEFLKKES Aquifex aeolicus NYSGXRC-6147a SGX Pharmaceuticals 2004-05-06 active Selected Cloned Expressed Soluble Purified EC4850 ICEDB: T1803 GENBANK NP_228089.1 MIDLKQYEFWFLVGSQYLYGLETLKKVEQQASKIVDSLNDDPIFPSKIVLKPVLKSSSEITEIFEKANADPKCAGV IVWMHTFSPSKMWIRGLSINKKPLLHLHTQYNREIPWDTIDMDYMNLNQSAHGDREHGFIHARMRLPRKVVVGHW EEKEVREKIAKWMRVACAIQDGRMGQIVRFGDNMREVASTEGDKVEAQIKLGWSINTWGVGELAERVKAVPEREV EELLKEYREKYIMPEDEYSLKAIREQAKIEIALREFLKEKNAVGFTTTFEDLHDLPQLPGLAVQRLMEEGYGFGA EGDWKAAGLVRAIKVMGTSLPGGTSFMEDYTYHLTPGNELVLGAHMLEVCPTIAKEKPRIEVHPLSIGGKADPAR LVFDGQEGPAVNASIVDMGNRFRLVVNKVLSVPIERKMPKLPTARVLWKPLPDFKRATTAWILAGGSHHTAFSTA IDVEYLIDWAEALEIEYVVIDENLDLEDFKKELRWNELYWGLLKR Thermotoga maritima NYSGXRC-6147b SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble EC4850 GENBANK NP_347974.1 MLENKKMEFWFVVGSQHLYGEEALKEVRKNSETIVDELNKSANLPYKIIFKDLATSADKIKEIMKEVNYRDEVAGV ITWMHTFSPAKMWIAGTKILQKPLLHFATQYNENIPWKTIDMDYMNLHQSAHGDREYGFINARLKKHNKVVVGYW KDKEVQKQVSDWMKVAAGYIASESIKVARFGDNMRNVAVTEGDKVEAQIQFGWTVDYFGIGDLVAEMDKVSQDEI NKTYEEFKDLYILDPGENDPAFYEKQVKEQIKIEIGLRRFLEKGNYNAFTTNFEDLYGMKQLPGLAVQRLNAEGY GFAGEGDWKTAALDRLLKVMTNNTATGFMEDYTYELSRGNEKALGAHMLEVDPTFASDKPKVIVKPLGIGDKEDP ARLIFNGSTGKGVAVSMLDLGTHYRLIINGLTAVKPDEDMPNLPVAKMVWKPEPNFIEGVKSWIYAGGGHHTVVS LELTVEQVYDWSRMVGLEAVIIDKDTKLRDIIEKTTK Clostridium acetobutylicum NYSGXRC-6147c SGX Pharmaceuticals 2004-03-27 active Selected Cloned Expressed EC4850 MKKLNIALLGLGTVGSGVVKIIEENRQQIQDTLNKDIVIKHILVRDKSKKRPLNISQYHLTEDVNEILNDDSLDII VEVMGGIEPTVDWLRTALKNKKHVITANKDLLAVHLKLLEDLAEENGVALKFEASVAGGIPIVNAINNGLNANNI SKFMGILNGTSNFILSKMTKEQTTFEEALDEAKRLGFAEADPTDDVEGVDAARKVVITSYLSFNQVIKLNDVKRR GISGVTLTDINVADQLGYKIKLIGKGIYENGKVNASVEPTLIDKKHQLAAVEDEYNAIYVIGDAVGDTMFYGKGA GSLATGSAVVSDLLNVALFFESDLHTLPPHFELKTDKTREMMDSDAEINIKEKSNFFVVVNHVKGSIENFENELK AILPFHRSLRVANYDNQSYAAVIVGLESSPEELITKHGYEVDKVYPVEGV Staphylococcus aureus NYSGXRC-6147d SGX Pharmaceuticals 2004-04-15 active Selected Cloned Expressed Soluble Purified EC4850 ICEDB: T1813 MLQTKPYTFWFITGSQHLYGEDAIEQVRQHSQTMVEKLNKIGELPYTIELKEVLTTPDAIRKMVIAANSDDDCAGM ITWMHTFSPAKMWINGLKQLKKPLLHLHTQFNREIPYDDIDMDFMNLNQSAHGDREYGHIGARLNISRKVIVGHW QNNDVQERLGAWMRTAAAFVDGHHLKVARFGDNMREVAVTEGDKVEAQIQFGWSITAFGIGDLVEKMKAVSEDEV RRLFDEYQELYRLSPSILEQDEVKAAVLEQAKMELALKEFLEEGGYTAFTTNFEDLHGMKQLPGLAVQRLMAEGY GFGGEGDWKTAALLRMMKIIADGKGTSFMEDYTYHLAEGNELVLGSHMLEICPTIAANQPEIQVHPLGIGGKEDP ARLVFDGADGPALNASLIDLGHRFRLVVNEVEAIKPERDMPKLPVAKVLWKCKPSLSEATEAWIHAGGAHHTVFS FEVTPEQLYDWATLADIEVVFINDKTDVLQFQQQLQWNEAFRRLFK Bacillus halodurans NYSGXRC-6148a SGX Pharmaceuticals 2004-05-04 active Selected Cloned Expressed Soluble Purified EC486 ICEDB: T1807 GENBANK NP_116670.1 MARDLQNHLLFEVATEVTNRVGGIYSVLKSKAPVTVAQYGDNYTLLGPLNKATYESEVEKLDWEDESIFPEELLPI QKTLMSMREKGVNFVYGNWLIEGAPRVILFELDSVRHFLNEWKADLWSLVGIPSPEHDHETNDAILLGYVVVWFL GEVSKLDSSHAIIGHFHEWLAGVALPLCRKKRIDVVTIFTTHATLLGRYLCAAGDVDFYNNLQYFDVDQEAGKRG IYHRYCIERAAAHTADVFTTVSQITALEAEHLLKRKPDGILPNGLNVVKFQAVHEFQNLHALKKDKINDFVRGHF HGCFDFDLDNTVYFFIAGRYEYKNKGADMFIESLARLNYRLKVSGSKKTVVAFLIMPAKTNSFTVEALKSQAIVK SLENTVNEVTASIGKRIFEHTMRYPHNGLESELPTNLDELLKSSEKVLLKKRVLALRRPYGELPPVVTHNMCDDA NDPILNQIRHVRLFNDSSDRVKVIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSI TTNVSGFGAYMEDLIETDQAKDYGIYIVDRRFKSPDESVEQLADYMEEFVNKTRRQRINQRNRTERLSDLLDWKR MGLEYVKARQLGLRRAYPEQFKQLVGETISDANMNTLAGGKKFKIARPLSVPGSPKVRSNSTVYMTPGDLGTLQD ANNADDYFNLSTNGAIDNDDDDNDTSAYYEDN Saccharomyces cerevisiae NYSGXRC-6148b SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC486 LATYFMYPSTGGLNTYIAVLKKTLEAQGYTVDVLARKPGPRLHLLSEEINMNTLRKMMSKPLNHYYKKHGQFSEPY IIKQELDRYVFELSSALLPIETYDLIHAQDVVSTRALARVKPAHIPLVTTIHGLYSEERFNRGVIQTKNDHSWKY SLAQEYIGALSADKVIVLTNWMRQRFQDQLNISSHHFETIPNGMFIEEFTNKLTNKTQVHIPESKKFTILCPARL VAEKDHRTLIDAVQLLKKEREDFICLLAGDGELREELEGYCREKEVQDVCLFLGNRNDIPELMNRSDLVVLPSLQ ENLPFTVMEAQVAGKPLIVSNAGGLPEMVHDGVTGRLFKKRDSRQLAFILKELMDHDEDRQLLGNNAKDWGRSQW SANTFCEKIKTVYAEALEQKKKEPRLMEFESVNRPTYHTLELHRFFEKSLWKKIDQCLPSNYTIPDPAFIKSLTT Y Bacillus halodurans NYSGXRC-6148c SGX Pharmaceuticals 2004-12-03 active Selected Cloned Expressed Soluble EC486 GENBANK NP_393819.1 MESRGNSTGILRGSQRWSFLRISVIGWELPPAFSGGLGIHTVNLFSIIGQLRDVTLYVPDLGYDFPQYPFRVRKVR ISKARFLSGYAVIDDFYETVMDYNDRVVEQFDPDGVDVVHCHDWITFSAGLRIREKYGIPLVVTFHSTEFDRSAF FNPQERIMSIERDGARNADRIICVSNLTRRMIVENYGADDTKIRTIYNGVDPYPYLSHPDEKRERDVLYFGRVTS QKGPKFFMEVAKKVLELDGSVKFTVAGTGELLPEMKRYAFENGFLNHMDFTGFVSFRRAISYYKRSSVFIIPAVS EPFGMTVLEAMISGTPVILSKTTGVGEALNHVLSADFWDTDKMALYTISILNHRGLLKTLSEYGKMEAMRFTWRR AALSTMEVYDSL Thermoplasma acidophilum NYSGXRC-6148d SGX Pharmaceuticals 2004-04-14 active Selected Cloned Expressed Soluble EC486 GENBANK NP_349671.1 MKVALVHDWLTNMGGAERVIINLKEIYKEAPIYTSLYNPDKLDDELRNIDVRTSFLQKPKNIKRGHQKLLPFMPMA FESFDLNEYDIVLSSCSSCAKGVVTNPNTMHVCYCHTPMRYAWEYYYEYADEWGLNKLKGKLLKYVMNYIRLWDG VSSKRVDYYIANSQNVAKRIWKHYKRESVVIHPPVRCKLFDISDVNEEYFLIVSRLVPYKRIDLAVEVFNELGLP LVVIGGGKDLDRLKNMAKDNIKFLGRQSDEVIKEYYSKCRAFIFPGEEDFGITPLEAQASGRPVIAYGKGGALET VVSGVTGVFFKEQTVDSLKSAVNEFEKINFDKSVIRRHAEEFDEEIFKKKIREYLSRSYDEFKKLKKWKVI Clostridium acetobutylicum NYSGXRC-6148e SGX Pharmaceuticals 2004-02-23 active Selected EC486 MNPLRIGLFTDTFLPDQNGIVTSVCLLSDELRALGHQVDVVAPRFPEHLDRRPDVRRVASVRYPLLPTYRLAWPGR RSFEQRYDLIHTHTPLTLGLAGARLARKWGVPHVATYHTHLEAYTHYVPGMTQLNRAVHFMPKVVGRLYGEADAV ITPTAGTLDTLRQAGITDAVVIPTSIDPAVLEAAPPIASPWPPGTRRLLTVGRLAREKRFDLVLDTLADLPGAHL VILGEGPERTHLEDHAQRLGVAEHVTFVGVRPWTEIGAYYRLAELFVFASDTETQGLVLQEAQLMGVPVVAVGAR GTLTGVQSGYSGYLTAPGDVPELVRRARELLESPEQYARFSRQAREFGGRTTPAGVARQVLAVYARTLGLPPESP DDPRADGLSAPAEAAGRPRNNPVYGR Deinococcus radiodurans NYSGXRC-6149a SGX Pharmaceuticals 2004-05-13 active Selected Cloned Expressed Soluble Purified EC835 ICEDB: T1836 GENBANK NP_010239.1 MQLSKAAEMCYEITNSYLHIDQKSQIIASTQEAIRLTRKYLLSEIFVRWSPLNGEISFSYNGGKDCQVLLLLYLSC LWEYFFIKAQNSQFDFEFQSFPMQRLPTVFIDQEETFPTLENFVLETSERYCLSLYESQRQSGASVNMADAFRDF IKIYPETEAIVIGIRHTDPFGEALKPIQRTDSNWPDFMRLQPLLHWDLTNIWSFLLYSNEPICGLYGKGFTSIGG INNSLPNPHLRKDSNNPALHFEWEIIHAFGKDAEGERSSAINTSPISVVDKERFSKYHDNYYPGWYLVDDTLERA GRIKN Saccharomyces cerevisiae NYSGXRC-6149b SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC835 GENBANK NP_587730.1 MDELERVYQSIKNIFTHSAPSEKLVGLQNRLSISLRFIEYAFETYQPERLAMSFNGGKDCLVLFLLCIYYLKEKYK EQAQAKLSNIPFVFVRPRDEFPEMDDFVNECQSKYRLNIIKISLPMKEAFCKFLKEHKHIQAILIGIRRLDPHGL HRIAFEVTDKGWPKFMRIQPILDWSYTEIWDLLLETNTKYCSLYDRGYTSLGGVSDTSPNPALKNPDGTYSPAYL LSDGSLERAGRNNTVPFSRTNSRFLYDSGASSYASSEVS Schizosaccharomyces pombe NYSGXRC-6150a SGX Pharmaceuticals 2004-03-29 active Selected Cloned EC651 GENBANK CAA85352.1 MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQE IPYLPSAYIKYISSSNYKLHPEEQISFTSEEIEGKPTHYKLKILVSGSWKDTILMRSLTVLISEAYLIVTSTGLR NHRQAEKKAETLFDNGIRFRIHGTRRRRSLKAQDLIMQGIMKAVNGNPDRNKSLLLGTSNILFAKKYGVKPIGTV AHEWVMGVASISELDYLHANKNAMDCWINTFGAKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYT KKISHHYHDVLKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRKKSEPQVKSEPLNIVIK LLEVNGNHAIKISDNLGKNMGDPATVKRVKEELGYTERSWSGDNEAHRWT Saccharomyces cerevisiae NYSGXRC-6151a SGX Pharmaceuticals 2004-05-06 active Selected Cloned Expressed Soluble Purified EC288 ICEDB: T666 GENBANK NP_390627.2 VNEMEKRPEDTRVVVGMSGDIDSSVAALLLKEQGYDVIGIFMKNWDDTDENGFCTATEDYEDVIRVCNQIGIPYYA VNFEKQYYEKVFQYFLDEYKAGRTPNPDVLCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDE NKDQTYFLNQLTEDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQPGDMM TMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHNPLLYSDKITATNISWVRSDIMK GEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQVRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV Bacillus subtilis NYSGXRC-6151b SGX Pharmaceuticals 2004-05-17 active Selected Cloned Expressed Soluble EC288 GENBANK BAB59586.1 LLVMKCSKCSAEAIYYAKYNGLYLCRDHFNEMIEGRVKKEIRKQVEFHGDDVTISVALSGGKDSSVTLFLLHKILG NRKNMKIKAFTVDEGIDGYRPSGLESAKRLCTSLGIDHETISFYDSYGLTLDSIVKTNPVKIPCAYCGPLRRKLI NEMADKQDADYVALGLNLDDYSQSILMNVAKGDFDRFIRMSPQTDRKVGLVRRIAPLRTILEKEVVLYAVTNDIP FDSSWCPYYSRAQRNVFREVVNKLSEENPSTKFAILKFFDRVRENITTGHEEVKLKRCKICGAPTERDVCTACSS LQEVNEMMAEH Thermoplasma volcanium NYSGXRC-6151c SGX Pharmaceuticals 2004-05-06 active Selected Cloned Expressed Soluble Purified EC288 ICEDB: T1912 MLWGESMEEIVNKITKFIREKVEEANANGVVVGLSGGIDSSVTAYLCVKALGKDKVLGLIMPEKNTNPKDVEHAKM VAENLGIKYIISDITDILKAFGAGGYVPTREFDKIADGNLKARIRMCILYYFANKYNLLVAGTSNKSEIYVGYGT KHGDIACDIRPIGNLFKTEVKKLAKYIGVPKEIIEKPPSAGLWEGQTDEEELDIKYETLDTILKLYEKGKTPEEI HKETNIPLETINYVFDLIKKNEHKRTLPPTPEI Methanococcus jannaschii NYSGXRC-6152a SGX Pharmaceuticals 2004-05-05 active Selected Cloned Expressed Soluble EC1569 VAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLAKLQDDIYKNLKPWDRVQIARLADRPTTLDYIE HLFTDFFECHGDRAYGDDEAIVGGIAKFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNR PIICFIDTKGAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLENSTYSVISP EGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVKLQASYMDETLKQSLKTLLKLSEEEL VQQRYEKYKAIGKVSVEDQYIGVN Bacillus subtilis NYSGXRC-6152b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC1569 GENBANK NP_519290.1 MKTTFLEFEQPIAELEAKIEELRFVQDDSAVDISEEISRLAAKSQQLTKDLYATLSPWQVAQIARHPQRPYTLDYV REIFTDFHELHGDRTFADDLSIVGGLARFNGQPCMVIGHQKGRDTKERALRNFGMSKPEGYRKAKRLMELADKFG LPIFTFVDTPGAFPGIEAEERGQSEAIGHNLFVMAGLKVPLIATIIGEGGSGGALAIAVGDSVIMLQFATYAVIS PEGCASILWKTAEKAPEAAEALGLTAHRLKALGLIDKIVNEPLGGAHRDPKAMATMLKRALAESLRQFQGMKTSE LQARRHERLMAYGKFKETGSN Ralstonia solanacearum NYSGXRC-6152c SGX Pharmaceuticals 2004-11-29 active Selected EC1569 MATTERKPLLLDFEKPLAELANRIDQIRQLAEENGVDVSGEIRKLETRAMQLREEIFSTLSPSQRLQVARHPRRPS TLDYIQAISDEWMELHGDRCGGDDPALIGGVARLGGKPVVILGHQKGRDTKDNIARNFGMATPGGYRKAMRLMEH ANKFSMPILTFIDTPGALPTVVAERQGAGEAIAYNLREMFSLDVPIICTVIGEGGSGGALGIGVGDRLLMFEHSV YTVATPEACAAILWKDASKSPQAAVALKIVSHDLKNLGIIDQILPEPTGGAHSDPLTAATTLKQALLDNLDELDR LTSQERRQLRYDKFRKIGVFTEVAH Nostoc sp. NYSGXRC-6152d SGX Pharmaceuticals 2004-03-30 active Selected Cloned Expressed EC1569 GENBANK NP_297496.1 MNPNYLDFEQPIADLEAKIQELHTASMGPSINVDTEVRALENKLRLRTAQIFRNLSAWQISQLARHPRRPYTLDYI SVVCDEFQELAGDRALADDKAIVGGLARIGHRPVMLIGHQKGRDNKERLMRNFGMPKPEGYRKALRLMKLAERFG LPLLTFIDTMGAWPGIDAEERNQSEAIATNLIEMAELKIPVICTVIGEGGSGGALAIGIGDRTLMLEYSTYSVIT PEGCASILWKDAAKASDAAEQLNLTARRLKEFGLIDKVIREPIGGAHRNPQQMANRLKAVLLNELEALDKVPLVT LLNQRHKRLRTYGAYENH Xylella fastidiosa NYSGXRC-6152e SGX Pharmaceuticals 2004-03-29 active Selected Cloned EC1569 GENBANK NP_274168.1 MKPVFLDFEQPIAELTNKIDELRFVQDESAVDISDEIHRLQKKSNDLTKSIFSKLTPAQISQVSRHPQRPYTLDYI EALFTDFEELHGDRHFADDYAIVGGLARFNGQSVMVVGHQKGRDTKEKIRRNFGMPRPEGYRKALRLMKTAEKFG LPVMTFIDTPGAYPGIGAEERGQSEAIGKNLYELTRLRVPVLCTVIGEGGSGGALAVALGDYVNMLQYSTYSVIS PEGCASILWKTAEKAADAAQALGITADRLQKLDLVDTVIKEPLGGAHRDFGQTMKNVKAVLEKQLHEAQSIPLAD LLSRRFDRIMAYGKFSEQ Neisseria meningitidis NYSGXRC-6152f SGX Pharmaceuticals 2004-05-05 active Selected Cloned Expressed Soluble EC1569 GENBANK NP_142271.1 VDPLSGFLGSLIWWFLFLYLLLWPQMQYRQLQLAREKLLERLARKRNSTVITLIHRQESIGLFGIPVYRFISIEDS EEVLRAIRMAPKDKPIDLIIHTPGGLVLAATQIAKALKDHPAETRVIVPHYAMSGGTLIALAADKIIMDPHAVLG PVDPQLGQYPAPSIVRAVEKKGVDKVDDQTLILADVAEKAIRQVRDFIFNLLKDKYGEEKAKELAQVLTEGRWTH DYPITVEEAKKLGLNVSTDVPEEVYALMELYKQPIRQRGTVEFVPYPMKQEGKH Pyrococcus horikoshii NYSGXRC-6152g SGX Pharmaceuticals 2004-03-28 active Selected Cloned Expressed EC1569 GENBANK NP_372224.1 MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIF DSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIF TFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGA AALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDVEQQALAIKSAFVAQLDSLESLSRDEIAND RFEKFRNIGSYIE Staphylococcus aureus NYSGXRC-6152h SGX Pharmaceuticals 2004-04-21 active Selected Cloned Expressed Soluble EC1569 GENBANK NP_350151.1 MENSQELTPWQRLTIARMLERPTSLEYIDLIFDSFMEFHGDRAFGDDAAIVGGVAEFNGMPVTVIGQQKGRNTNEN IKRNFGMPSPEGYRKALRLMKQAEKFNRPLICFVDTSGAYCGVEAEQRGQGEAIAKNLISMANLKIPVISVVIGE GGSGGALAMAVADEVWMLENSVYSLLSPEGFASILWKDSSRAKEAAEVMKITADDLKGYGIIDKVIKEPDGGAQN DITMVANALRENLKKAIEGLSSTGINELLDNRYNKFRQIGKFIENEDN Clostridium acetobutylicum NYSGXRC-6152i SGX Pharmaceuticals 2004-06-25 active Selected Cloned Expressed Soluble Purified EC1569 ICEDB: T1861 GENBANK NP_252329.1 MNPNFLDFEQPIADLQAKIEELRLVGNDNALNISDEISRLQDKSKALTENIFGNLSSWQIAQLARHPKRPYTLDYI GYLFSDFEELHGDRHFADDPAIVGGVARLDGSPVMVIGHQKGREVREKVRRNFGMPRPEGYRKACRLMEMAERFK MPILTFIDTPGAYPGIDAEERGQSEAIAWNLRVMARLKTPIIATVIGEGGSGGALAIGVCDQLNMLQYSTYSVIS PEGCASILWKTAEKAPEAAEAMGITAERLKGLGIVDKVIDEPLGGAHRDPASMAESIRGELLAQLKMLQGLEMGE LLERRYDRLMSYGAP Pseudomonas aeruginosa NYSGXRC-6152j SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC1569 GENBANK NP_215419.1 VSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGG SIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVF ASWGSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPE PLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQR AVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLG QGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAAD EPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD Mycobacterium tuberculosis NYSGXRC-6152k SGX Pharmaceuticals 2004-02-23 active Selected EC1569 GENBANK NP_294938.1 VTSTPADALRELEARVRDLEATAERTGQNLDAALAPLRTQLETLRREHAAGLSRWDRVQLARTPGRPTALDYVDRL CSDWTELHGDRRFGDDPALIGGPARWQGRPVMLLLQQKGRDTKTKIKRRFGSANPEGYRKAIRLMDLADRFGLPV VSLIDTQGAYPGLEAEERGQGWAIAESIQRMVRLRVPAVCAVIGEGGSGGALAIGVGNRVLIQENAWYSVISPEG AASILWRDAAQAPLAAEALRVTAADLLDMGIVEEVVPEPPGGAHLDMDAAAEALGSVISRHLDDLSALTPDDLLA QRAARFRSLGAFEER Deinococcus radiodurans NYSGXRC-6153a SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC481 GENBANK AAA34439.1 MSDRFVIWAPSMHNEPAAKCGYCHGNKGGNMDQLFALDSWAHRYMNKMDVVKIENCTIGSFVEHMDVATYDRMCNM GFRRSGKFLYKVDPLRNCCRLYTIRTAPQELNMTKELKKCISRFASRITSEDYCPAAVASSDFVGKIVNAEMNSK TFYTRFEPALYSEEKYHLFVKYQEKVHQDYNNSPKSFKRFLCDTPFGPEAVLGTQESWEQLNNWQRMKPGEKLKH MGPVHECYYYEGKLIAITVSDILPSGISSVYFIWDPDYSKWSLGKLSALRDLAIIQRTNLQYYYLGYYIEDCPKM NYKANYGAEVLDVCHSKYIPLKPIQDMISRGKLFVIGEEETKVTKELYLVDSETGRGEGFPTDNVVKYKNIAEEI YGVGGCAFKSANESALELKELYGIPIEEEDLDTIYHLKEHNGHAPNGIPNVVPGLLPLWELLDIMQSGKITDLEG RLFLFEIETEGIRPLINFYSEPPNVKKRICDVIRLFGFETCMKAVILYSEQM Saccharomyces cerevisiae NYSGXRC-6153b SGX Pharmaceuticals 2004-03-30 active Selected Cloned Expressed EC481 GENBANK NP_593608.1 MVLDKLLYTGYNRLIDLGWRRSGHYLYKPNGKTSCCSLYTIRLDSYNFKIAKEQKKAIKKWVKYVNGKPLKPMKSE ISTDYLNNAFQTIESLGAEKYSVTMEPCTYTDEKFEVFKKYQMQVHLEKEEEITKKGFSRFLCNSPLFNEDKGIK YGSYHQMYRFQGRLVAVGVLDLLPHGVSSVYLFYDPDMSKFSLGRISACREIWLALECGYRYYYMGYYIHTCPKM KYKATYSPSYLLNPGTNKWIPIENFTSLWNTGAPKYISFGDENNSDIQTAVDYDSSEDSSQNEDDYTLFNRQLPG ILSVNVAESLVSENFANIGNSTFPTRHVLSYFPQVKHWFVEINAAVGEEVAKSYTLVLSS Schizosaccharomyces pombe NYSGXRC-6154a SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble EC1270 GENBANK NP_010872.1 MAPIFRNYRFAIGAFAVIMLILLIKTSSIGPPSIARTVTPNASIPKTPEDISILPVNDEPGYLQDSKTEQNYPELA DAVKSQTSQTCSEEHKYVIMIDAGSTGSRVHIYKFDVCTSPPTLLDEKFDMLEPGLSSFDTDSVGAANSLDPLLK VAMNYVPIKARSCTPVAVKATAGLRLLGDAKSSKILSAVRDHLEKDYPFPVVEGDGVSIMGGDEEGVFAWITTNY LLGNIGANGPKLPTAAVFDLGGGSTQIVFEPTFPINEKMVDGEHKFDLKFGDENYTLYQFSHLGYGLKEGRNKVN SVLVENALKDGKILKGDNTKTHQLSSPCLPPKVNATNEKVTLESKETYTIDFIGPDEPSGAQCRFLTDEILNKDA QCQSPPCSFNGVHQPSLVRTFKESNDIYIFSYFYDRTRPLGMPLSFTLNELNDLARIVCKGEETWNSVFSGIAGS LDELESDSHFCLDLSFQVSLLHTGYDIPLQRELRTGKKIANKEIGWCLGASLPLLKADNWKCKIQSA Saccharomyces cerevisiae NYSGXRC-6154b SGX Pharmaceuticals 2004-03-28 active Selected Cloned Expressed EC1270 GENBANK NP_593447.1 MTPTMKSIARRKALLIALSIFAVTFILWNGFPGSSNRPLPSSNDEFHYEDIELPSGYRSEGEVVDLLNPKDELEEP LFSEEPLFPVTTSIPTKTAVSKPKIAPTSAAKDVTFSSSIDSDDCSVAYDNSKPVRQYVLMIDAGSTGSRVHVYQ FNNCNPSPKLEEEFFKMIEPGLSSFAGDPEGAAASLDPLLDYAMENVPEEYRRCSPIAVKATAGLRLTGESEAKA ILKSVRQHLENDYPFPIVKDGVSILEGSMEGIYAWITINYLLGTLGGKATHSTVAVMDLGGASTQLVFEPRFASD GESLVDGDHKYVLDYNGEQYELYQHSHLGYGLKEARKLIHKFVLNNAEALKESLELLGDSTSIIHPCLHLNASLT HPDSKSEASEVVFVGPSLAHLSLQCRGIAEKALYKDKNCPVRPCSFNGVHQPKFTETFTDSPIYLISYFYDRMIS LGMPSTFTIEDMKYLANSVCSGPTYWQDAFSLTDALKELKEEPEWCLDLNYMISLLSVGYEIPNNRQLHTAKKID NKELGWCLGASLSMLSEQNNGWNCNVKEEI Schizosaccharomyces pombe NYSGXRC-6155a SGX Pharmaceuticals 2005-02-23 active Selected Cloned Expressed Soluble Purified EC889 GENBANK NP_414709.1 MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWSGDAFDNGISAEQLIEARTEFIDQLLQRLW IEAGFSQIADLALVAVGGYGRGELHPLSDVDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLE GLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGL RDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNY SGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLTRTLIDLRDETLFMRQPEAI LRMFYTMVHNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQW SHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGHHSI LGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICAT NETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHS PNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDT FIVLEPDGNPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPG LLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG Escherichia coli NYSGXRC-6155b SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC889 GENBANK NP_231893.1 LHGRAMPYQSPITFQEPQLTVESLKQQLESFTEYQKQEFFDHHPVTDLVLGRSEYMDLLLHRLWQFFGFDELVEVS LVAVGGYGRGELHPLSDIDLLVLSQQPLSEQVANKISQFLTLLWDLKLEIGHAVRTVEQCAEIGKADLTVATNLQ EARLLCGCEETFHRLKMVIHSESFWPSEIFYQAKVREQKERHARYHDTTYNLEPDIKSTPGGLRDIHTLSWVARR HFGATSLYEMSRFGFLTDAEYRELVECQDFLWRVRFALHIELKRYDNRLTFAHQVQVARHLGYFGEGNRGIEMMM KEFFRTLRRVAELNKMLLKIFDKAILNNGEEAEAVIIDDDFQRRGNMIEARKPALFQARPETILDMFLHMASDST IESVAPATMRQLRTARRRLNKFLHTLPAAREKFIELVRHPNALHKAFSQMHKLGVLAAYLPQWNQIVGQMQFDLF HVYTVDEHSIRLLKHIHLFSDANNHDRHPICCEIYPKIQKKELLILAAIFHDIGKGRGGDHSEIGADEAFDFCIE HGLSKPEAKLVAWLVKNHLLMSVTAQRRDIYDPDVIIEFAKKVRDEERLEYLVCLTVADICATNPELWNSWKRTL LAELFYSTQRALRRGLENPVDVRERIRHNQQMASALLRKEGFSSREIEVLWQRFKADYFLRHTHKQIAWHCTHLL RHEDSSKPLVLLSKKATRGGTEVFIYTKDQAALFATVVAELDRRNLNVHDAQIMASKDGYVLDTFMVLDQNGQAI EEDRHQALIRHLVHVLEDGRPTTQKARRIPRNLQHFKVKTQVDFLPTKSKKRTLMEFVALDTPGLLATVGATFAE LNLDLHAAKITTIGERAEDLFILTNAQGTRLNEEEEQHLREKLIEHVAELAPSAQ Vibrio cholerae NYSGXRC-6155c SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble Purified EC889 GENBANK NP_577953.1 VNKRCEEVLRRYFAEVPFIIEKACELAESMLGEGSHGLSHTIRVLDLALQIGRVEGANLEVLALAAILHDIARPLE DKGRIKDHAQEGARIVRSFLSKLRYPHVDEVAHAIEAHRFSTNIEPRTLEAKILSDADKIDALGAIGIARVFMYA GEKGRSIEDSIKHFEEKILRLKDLMYTETGKRIAQERHKIVEEFVNILKKELI Pyrococcus furiosus NYSGXRC-6156a SGX Pharmaceuticals 2004-03-29 active Selected Cloned EC1615 GENBANK BAA32344.1 PFAM PF00696 MAQQLSARQPRYKRILLKLSGEALMGSEEFGIDPKVLDRMALEIGQLVGIGVQVGLVIGGGNLFRGAALSAAGMDR VTGDHMGMLATVMNGLAMRDALERSNIPALVCRSYLHGRCDRPLRPPQGHAHLGGGEVVIFSAGTGNPFFTTDSA ACLRAIEIDADVVLKATKVDGVYTADPFKDPNAEKFERLTYDEVLDRKLGVMDLTAICLCRDQNMPLRVFNMNKP GALLNIVVGGAEGTLIEEG Pseudomonas aeruginosa NYSGXRC-6156b SGX Pharmaceuticals 2004-02-23 active Selected EC1615 PFAM PF00696 LLKRREPDMFKRVLLKLSGEFLAGDNGFGISPETTAELARRIIGALDGTEVELAVVIGGGNLWRGARNGQGMDPAT ADYIGMLGTVMNAMALQDAMEAAGKPTRIMSAIHMQQVAEPYIRRRAMRHLEKGRVVIFGGGNGAPFFTTDTTST LRALEIGADVVLMAKNAVDGVYDSDPRKNPDAKRYEQLTHMDVVEQRLEVMDATALTLCMDKGLPIVVFDIFEEG NLARLLRGERVGTLIQSRG Deinococcus radiodurans NYSGXRC-6156c SGX Pharmaceuticals 2004-12-01 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T2199 PFAM PF00696 MQSIKYKRVMLKISGEALAGTNGYGIDFEVANRIAKEIKEIVDLGIEVGAVVGGGNIWRGRNGKGMDRTTADYMGM LATCINALALQDSLENMDVDTRVQTAIEMKQVAEPFIRRRAMRHLEKGRVVIFAGGTGNPYFSTDTTAALRAAEI EADVILLAKKVDGVYDKDPHKYDDAIKFDNLTYMEVLEKNLQVMDSTATSLCMDNNIPIIVFGLDVSGNIRKAVL GEKIGTIVSK Clostridium acetobutylicum NYSGXRC-6156d SGX Pharmaceuticals 2004-04-23 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1829 PFAM PF00696 GENBANK NP_420728.1 MSDTSAPQKYRRILLKVSGEVLMGDTPYGIDTNTVQSVAEDVAEIVKSGVELCLVIGGGNIFRGMAGAAKGMERSS ADYMGMLATVMNALAMQDALERIGVETRVQSAIPMATVCEPYIRRRAQRHLEKGRVVIFAAGTGNPFFTTDTAAA LRAAEMQCDALFKGTSVDGVYTADPKKDPTAQRYDRLSYMDVLAKDLRVMDASAVALMRDSNIPIVVFSIKGRGN LLTVLRGEGTHTVVAEDRAA Caulobacter crescentus NYSGXRC-6156e SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC1615 PFAM PF00696 MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIG GGNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRV VIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFS LCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT Mycobacterium tuberculosis NYSGXRC-6156f SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1841 GENBANK NP_721960.1 PFAM PF00696 MVKPKYSRVLIKLSGEALAGEKGVGIDIPTVQTIAQEIKEVHDSGIEIALVIGGGNLWRGEPASKAGMDRVQADYT GMLGTVMNALVMADALQHAGVDTRVQTAIAMQQVAEPYIRGRALRHLQKGRIVIFAAGVGSPYFSTDTTSALRAA EIEADAILMAKNGVDGVYNDDPRKNADAIKFNELTHMEVLKRGLKIMDSTASSLSMDNDIDLVVFNLNESGNIKR VIFGEQIGTTVTSRISDSE Streptococcus mutans NYSGXRC-6156g SGX Pharmaceuticals 2004-04-23 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1832 GENBANK NP_243291.1 PFAM PF00696 MAKYKRVVLKLSGEALAGEQGYGIDPEVIQSIASQIKEIVELDVEVAVVVGGGNIWRGMAGSAKGMDRATADYMGM LATVMNSLALQDSLENLDVQSRVQTSIEMRQVAEPYIRRRAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEI EAEVILMAKNKVDGVYNAEPSVDVNAKKYTSISYLDVLKEGLAVMDSTASSLCMDNNIPLIVFSIMEEGNIKKAV LGEEIGTVVRGSN Bacillus halodurans NYSGXRC-6156h SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC1615 GENBANK NP_231889.1 PFAM PF00696 MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAKAGMNRVVG DHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWSDAIRELRQGRVVIFAAGTGNPFFTTDSAACL RGIEIEADVVLKATKVDGVYSADPVANPDAQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGAL RRVVMGEAEGTLISDVQ Vibrio cholerae NYSGXRC-6156i SGX Pharmaceuticals 2004-04-16 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1810 PFAM PF00696 MVKPKYQRVVLKLSGEALAGEDGFGIKPPVIKEIVQEIKEVHELGIEMAIVVGGGNIWRGQIGAQMGMERAQADYM GMLATVMNALALQDTLENLGVPTRVQTSIEMRQIAEPYIRRRAERHLEKGRVVIFAGGTGNPYFSTDTTAALRAA EVDADVILMAKNNVDGVYSADPRVDETATKFEELTHLDVISKGLQVMDSTASSLSMDNDIPLVVFNLNEAGNIRR AILGENIGTTVRGK Enterococcus faecalis NYSGXRC-6156j SGX Pharmaceuticals 2004-04-16 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T2197 GENBANK NP_248255.1 PFAM PF00696 LILITLLKDGVGEKMRIVFDLGGSVVMPKEGAKAEKIMEYANIFKKIKDEGHEVAIVVGGGKTAREYIEIGRELGA SESFCDELGIMATRMNAMILITALGDYSIKKVPTSFEEAELILNLGKIPVMGGTHPGHTTDAVAASLAEFINADL LVIGTNVDGVYDKDPNKYEDAKKFDKMSAKELVDLAISSSLKAGSSSVVDLLAAKIIERAKLKVAVVKGTPEELL NVSKGIINGTIIEG Methanococcus jannaschii NYSGXRC-6156k SGX Pharmaceuticals 2004-11-28 active Selected Cloned Expressed Soluble EC1615 GENBANK NP_778571.1 PFAM PF00696 LRYPMSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVT GDHMGMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAA LRAIEIGADLLLKATKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGV LLRILHGEEIGTLVKERNSKS Xylella fastidiosa NYSGXRC-6156l SGX Pharmaceuticals 2004-05-03 active Selected Cloned Expressed Soluble EC1615 GENBANK NP_354383.2 PFAM PF00696 MMSSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGD HMGMLATVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAALHHLAQGRVVIFAGGTGNPFFTTDSAAALR AAEMGAEAIFKGTQVDGIYSADPKKDPTATRFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFA QILTGGGRKTIVHDK Agrobacterium tumefaciens NYSGXRC-6156m SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1821 PFAM PF00696 MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNYGAEKTGSDLGMDRATADYM GMLATVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAA EIEADVILMAKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKR AVIGESIGTIVRGK Bacillus subtilis NYSGXRC-6156n SGX Pharmaceuticals 2004-08-06 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1805 GENBANK NP_905987.1 PFAM PF00696 MTAYKRVLLKLSGESLMGAQQYGIDPNRLADYASDIKEACAMGVQIGIVIGGGNIFRGVSGAAKGFDRVKGDQMGM LATVINSLALSSALEGVGVKTKVLTAVRMEPIGEFYNKWHAIELLEQGYVTIFSCGTGNPFFTTDTGSSLRGIEI EADAMLKGTRVDGIYTADPEKDPSATKFDRITYDEIYARGLKVMDLTATAMCMENNLPIVVFDMDTPGNLLKVLR GEKIGTYVSNTSA Porphyromonas gingivalis NYSGXRC-6156o SGX Pharmaceuticals 2004-06-16 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1809 PFAM PF00696 MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVSAAKGGLIKRTSGDHMG MLATVINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQRHLEKGRVVVFAAGTGNPYFTTDTTAILRAVE IDADMVIKATKVNGVYDKDPKQFDDAVFLNTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKII QGDTSLCSTVKNN Campylobacter jejuni NYSGXRC-6156p SGX Pharmaceuticals 2004-04-29 active Selected Cloned Expressed Soluble Purified EC1615 ICEDB: T1848 GENBANK NP_579136.1 PFAM PF00696 MRIVFDIGGSVLVPENPDIDFIKEIAYQLTKVSEDHEVAVVVGGGKLARKYIEVAEKFNSSETFKDFIGIQITRAN AMLLIAALREKAYPVVVEDFWEAWKAVQLKKIPVMGGTHPGHTTDAVAALLAEFLKADLLVVITNVDGVYTADPK KDPTAKKIKKMKPEELLEIVGKGIEKAGSSSVIDPLAAKIIARSGIKTIVIGKEDAKDLFRVIKGDHNGTTIEP Pyrococcus furiosus NYSGXRC-6157a SGX Pharmaceuticals 2004-02-23 active Selected EC4605 MKNKSGNSYYREAVDIHSSLELSFILHKYHLRVDEKKSRNVFSAIRDELILDGDSRQNLATFCQTWIDDEIRELLN LSIDRNMIYKDEYPQMAEPEGRCVRMLSDSWSFPDSRHTLGCSTIGSSEAAMLGRLALKWQWCKKREVQGKSTEP DLRSCANMLA Escherichia coli NYSGXRC-6157b SGX Pharmaceuticals 2004-04-08 active Selected Cloned Expressed Soluble Purified EC4605 ICEDB: T1862 GENBANK YP_014994.1 MLYSEDDKRKQESYRIPLFGSEEESTSIPKYVLKKEPMEPRIAYQLVKDQLMDEGNARQNLATFCQTYMEKEAEIL MAETLEKNAIDKSEYPQTAELENRCVNILADLWNAPKDMSYLGTSTVGSSEACMLGGLAMKFRWRNNAEKRGLDI QAKRPNLIISSGYQVCWEKFCVYWDVDMRVVPMDKNHLSLDVDKVFDLVDEYTIGVVGILGITYTGKFDDIQLLD EKVEAYNETNEHQLVIHIDGASGAMFTPFVNPELPWDFRLKNVVSINTSGHKYGLVYPGVGWILWKDKEYLPKEL IFEVSYLGGSMPTMAINFSRSASQIIGQYYNFLRYGFEGYREIHEKTKKTAIYLAKTVEKSGYFEIINDGANLPI VCYKMKEGLDVEWTLYDLADQLLMKGWQVPAYPLPADLSDTIIQRFVCRADLGYNVAEEFAADFADAIHNLEHAR VLYHDKERNDSYGFTH Listeria monocytogenes NYSGXRC-6157c SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC4605 MDSSSVDIVLNKGGHNKSFEVKIYRIHTTKIMSFPNGSDAEGVLKRLEDYAKNDFEPHSRRMWGHIYYAGLKDVVE LARKAYLMYMDKTMLDFTCFPSLLRMEREVVRMASSLLNGDEEVVGNFTYGGTESIMLALKAAREKFRKEEGGNV VPEIVLPATAHPAFWKSAEYLGMRCLRAKLDDELRADVETVKELVGDKTAMIVGSAPNYPFGVVDDIKALSDIAV DGKLWLHVDACLGGFHLPFFRELGEKIPDFDFSVEGVHSISADFHKYGLSPRGASVILYRNAKLREGQIFVMASW PGYPLVNTAVLSTRSAGTLAAAWAVMSYLGFDGYLKLAKKTLYAKKRLIDGLTELGLELLGSPEGAVLAFTSERH NLFKVSTLMAEKGWYVQSQPGSKKLGFPRSLHFSVIPGHAEVVDEFLEDMREVLPECECSYPEMSSFDVSKLKFG EDGLPEDSELISELIHSMPPEIVESVFKQFINELIFR Archaeoglobus fulgidus NYSGXRC-6158a SGX Pharmaceuticals 2004-04-29 active Selected Cloned Expressed Soluble Purified EC4841 ICEDB: T1849 GENBANK NP_012080.1 MSNNKAGGEYEVITIGDAKKLQATISELGATLLDLKVNNESIVLGYPDIHGYISDGYNYIGATVGRYANRIYKGMF SMEDGPHQLTVNNCGNTNHSSISSFHLKKYKASKVQNPLDDLYIVEFTLLDDRTLPNEFPGDLAVNLKYTLNVAD MTLDLEYEAKLVSGEATPINMTNHTYFNLNKTMDKKSISGTEVRLCSDKSLEVSEGALIPTGKIVQRKIATFDSS KPTILQDDGPIYDYAFIVDENKNLKTTDSVSVNKLVPAFKAYHPASRLSLEVSTTEPTVLFYTGDNLCDGFTPRS GFAVEQGRYVDAINRDGWRDCVLLRRGEVYTSKTRYRFAV Saccharomyces cerevisiae NYSGXRC-6159a SGX Pharmaceuticals 2004-03-10 active Selected EC453 MNEIDEKNQAPVQQECLKEMIQNGHARRMGSVEDLYVALNRQNLYRNFCTYGELSDYCTRDQLTLALREICLKNPT LLHIVLPIRWPNHENYYRSSEYYSRPHPVHDYISVLQELKLSGVVLNEQPEYSAVMKQILEEFKNSKGSYTAKIF KLTTTLTIPYFGPTGPSWRLICLPEEHTEKWKKFIFVSNHCMSDGRSSIHFFHDLRDELNNIKTPPKKLDYIFKY EEDYQLLRKLPEPIEKVIDFRPPYLFIPKSLLSGFIYNHLRFSSKGVCMRMDDVEKTDDVVTEIINISPTEFQAI KANIKSNIQGKCTITPFLHVCWFVSLHKWGKFFKPLNFEWLTDIFIPADCRSQLPDDDEMRQMYRYGANVGFIDF TPWISEFDMNDNKEKFWPLIEHYHEVISEALRNKKHLHGLGFNIQGFVQKYVNIDKVMCDRAIGKRRGGTLLSNV GLFNQLEEPDAKYSICDLAFGQFQGSWHQAFSLGVCSTNVKGMNIVVASTKNVVGSQESLEELCSIYKALLLGP Saccharomyces cerevisiae NYSGXRC-6159b SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC453 LTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYFHGTPSSRLEGAFADGAARRTGFRLIAIDRPGY GRSTFQAGRNFRDWPADVCALADAFELEEFGVVGHSGAGPHLFACGAVIPRTRLAFVGALGPWGPLATPDIMRSL NAADRCYARLARSGPRLFGALFAPLGWCAKYTPGLFSTLLAAAVPAADKHLLSDERFGRHLRAIQLEAFRQGSRG AAYESFLQFRPWGFDLAEVAVPTHIWLGDRDSFVPRAMGEYLQRAIPHVDLHWAHGKGHFNIEDWDAILAACALD IGKRRGG Mycobacterium tuberculosis NYSGXRC-6160a SGX Pharmaceuticals 2004-05-03 active Selected Cloned Expressed Soluble EC554 GENBANK NP_248616.1 MKIVILAPTITPIVSYGGLGDVMRDLPKFLKKGNEVVVLTLNHYNRYFTLPYEDIKKITVIYKGAKITFDVLRTKH PTTGVDLIVFSNESVNNLNVWDPIKYEIFADLVITYLDEVKDIDVVSGHDWMCGLAIAKCNDILDLPTTLTIHNE AFKGEMIEYKGEVMTFLELGIKYADAVNTVSPSHAEEIKNYPYIKKYLNNKPFCGILNGIDIDEYDPMKIIERMC NLSNNKLDPRNYAYISPYSAEDSHNIKPKIKYSWFYRGGVYEYVEDWNKIDKGISATDVEVHGGVDGDIETPLIG FVGRATHQKGFNTMFEAIPELLEKHDIRFVFLTKGDRDIEERLKNLANEHDGRILALIGYSLPLSSLVFAGSDWI IMPSYWEPCGLVQMEAMAYCTPVIATETGGLKDTIIPLHPNPYEHPNFDKATGVLFKVPDKVGFMWGVEHALNWT FYKLNEICMFMQYIRYKCPKHPYDENSPLSMMMKNCYYHVFRNLSWQNSPSIRKYKGLFGGAIYNHYLQP Methanococcus jannaschii NYSGXRC-6160b SGX Pharmaceuticals 2004-05-13 active Selected Cloned Expressed Soluble Purified EC554 ICEDB: T1812 GENBANK NP_356569.1 MNVLSVSSEIYPLIKTGGLADVVGALPIALEAHGVRTRTLIPGYPAVKAAVTDPVKCFEFTDLLGEKADLLEVQHE RLDLLILDAPAYYERSGGPYLGQTGKDYPDNWKRFAALSLAAARIGAGVLPGWRPDMVHAHDWQAAMTPVYMRYA ETPEIPSLLTIHNIAFQGQFGANIFSKLALPAHAFGMEGIEYYNDVSFLKGGLQTATALSTVSPSYAEEILTAEF GMGLEGVIGSRAHVLHGIVNGIDADVWNPATDHLIHDNYSAANLKNRALNKKAVAEHFRIDDDGSPLFCVISRLT WQKGIDLMAEAVDEIVSLGGRLVVLGAGDVALEGALLAAASRHHGRVGVAIGYNEPLSHLMQAGCDAIIIPSRFE PCGLTQLYALRYGCIPVVARTGGLADTVIDANHAALASKAATGVQFSPVTLDGLKQAIRRTVRYYHDPKLWTQMQ KLGMKSDVSWEKSAGLYAALYSQLISKGH Agrobacterium tumefaciens NYSGXRC-6160c SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC554 MHIAFIHPSFPSAEGTGATHSATQIVSGLSELDHDIDVYCASEPQQNRLSSDINLYHLDGESQHPHTNTKLNREVK ARTNEFRKYDIVHSYLPSLIPSVANLGKNLDLSTVVTLNAYGGVCAKNDLLYLNEEHCEAKSNAKCLNCIARTGH QNNEQGYLYQTVSQLFSLRSINAGEDRLEYIDGFRAPSGHVRDNYTKFGFEEEKIHVIPHPLNDDFLVDHTSDFS EPINILYVGSLERHKGVDKLVPIIQGLRQREHDVELTVVGTGGLQSKMEEQSVNRNVEDYVDFAGFVSNEQLPSV YASHDVFIHPGIWEEPLARVYIEALATGTPIVTREYGSIETIIGDGGVTTDGSIDGFVQTIAELINANKLPALSE GGRSHVERYDRSQIVSQVEDLYGSVLT Halobacterium sp. NRC-1 NYSGXRC-6160d SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed Soluble Purified EC554 ICEDB: T1888 GENBANK NP_294317.1 LARGRPCLSAQRLGEEPRVNSTGRYSGPMRVLHLASEVFPFSRSGGLGDVLGALPAVQARLGEDAEVTVLSPWYAS LQGEPQELWRGEAWGEQAWLGELRQDGVRYLFLGLNEFQRPGLYHPDDVERFCAFGRAALPALDAVGVTPDVLHG HDWQAGLVVAHARLRGLRTAFSVHNLQYQGRWNLHEAAGWTGLPDWTFGPDGVEFFGDLNLMKAGLNFAGHVTTV SPTYAQEITTPQYGEGLEGLLVRLTHEGRLSGILNGLDQDRWNPRTDPDIAAYSDPAGKAGAVKALRQEFGLDDA PILATVSRLADQKGMDLLITALPELVRDWNVVVLGGGDPLLEAALTGWANHPRVAFASGMNEPLAHRIYAGAHAF AMPSRFEPCGLSQLIAMRYGTLPIVRETGGLADTVPPEVGFRFADATAPAFLQACREAQAAFQDPAQWQTRATRA MSLDFSWDGPARQYLELYRGL Deinococcus radiodurans NYSGXRC-6160e SGX Pharmaceuticals 2004-06-15 active Selected Cloned Expressed Soluble EC554 GENBANK NP_488416.1 MNSNTEKRIALISVHGDPAIEIGKEEAGGQNVYVREVGKALAQLGWQVDMFSRKVSPEQELIVHHSPLCRTIRLTA GPEEFVPRDNGFKYLPEFVQQLLRFQKENNVNYPLVHTNYWLSSWVGMQLKAIQGSKQVHTYHSLGAVKYKSIDT IPLVATKRLSVEKQVLETAERIVATSPQEQQHMRSLVSTKGYIDIVPCGTDIHRFGSIARQAARAELGIDQEAKV VLYVGRFDQRKGIETLVRAMNESQLRDTNKLKLIIGGGSTPGNSDGRERDRIEAIVQELGMTEMTSFPGRLSQDV LPAYYAAADVCVVPSHYEPFGLVAIEAMASGTPVVASDVGGLQFTVVSEKTGLLVPPKDIAAFNIAIDRILMNPQ WRDELGLAARKHVTHKFGWEGVASQLDGIYTQLLTQQVKEPALVTK Nostoc sp. NYSGXRC-6160f SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC554 GENBANK NP_250082.1 VVKVLSRGPVADAVPLLSILTACDCSVEEFERIAAFLETQTLKRWCWIHCPGVDSDCLPVEGMAVLYLPRAPAALR ATALEEAIWFLLSLPTLPWVELREDARRGDLFVSRRSLPEGRIGARLNGRRQPCSSAMLAPGSLPKAPGKRLLLL APWLEPGGADRCNLDLLRALAREGWMLTVVASLAAEHRWRDRFTALTADVWVLPDFLSAEKACGFLAYLVDSRQP DLMLLSNSAFAYDVLGYVRTRYPGLPVVDLNHMEEGWDDGGHPGRAARCTALLDRHWVVSGHLRHWLLDRGVEAS KVEVLHWFADVDSWKPDSLTRAKVRARLGIAPQCVVIAYAGRLCAQKRPELFAASLGELARRGSDFVALVLGDGE LAGELRNDLRRHGLAGRVRMLGWQDEAALRELFQASDIFFLPSAGEGIALVLYEAMACGMAIVAADVGGHAELVS AHCGFLVPRRDAEREARDYAARLESLMREPEMLGRMGQNSARRIREAFTLSLFERRLRELLERVPVSTPCGVCTD SPVPALGAARLSMQWASYRLANGLRCRLDIQKHGRFSRFLERCAKGVFFLRTFGAKALWQKIRKH Pseudomonas aeruginosa NYSGXRC-6160g SGX Pharmaceuticals 2004-02-23 active Selected EC554 MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIKDPNLADREKVDGVHYVHLDEDRYEEAVGAELK KSRFDLVHVCNRPSWVPKLKKQAPDAVFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSA RSKTKTVYSGVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIEEHPDVMMV FIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDVFVCSSQWQEPLARVHYEAMAAGLPI ITSNRGGNPEVIEEGKNGYIIHDFENPKQYAERINDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKN R Bacillus subtilis NYSGXRC-6161b SGX Pharmaceuticals 2004-04-22 active Selected Cloned Expressed Soluble EC1494 GENBANK NP_357459.2 MSLMLTVETRQAVNPDYAKTLDTEGLRRHFLANDMFRSGEIRLIYTHYDRFVMGGAVPNGAPLTLDKVEETKTPSF LDRREMGIVNIGETGTVSAGDETYTLNRGDVLYLGAGSRAVTFDGAGRFYITSCPAHRSLPAKLVSLADSKEVKL GATETSNKRTINQFIHPLVMESCQLVLGYTMLEDGSVWNTIPSHIHDRRMEAYLYFGMDEKSRVLHLMGEPQETR HLFISNEEGAISPPWSIHSGAGIGSYTFIWAMAGDNVDYTDMDFIQPGDLK Agrobacterium tumefaciens NYSGXRC-6161c SGX Pharmaceuticals 2004-05-04 active Selected Cloned Expressed Soluble Purified EC1494 ICEDB: T1825 GENBANK NP_390095.1 MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDRVVIGGAAPGQSELKLDAGDFLKTDFFLERREI GIINVGQPGAVRVGDDEYVLQTKDFLYIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGD DAASNVRSLYKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMGQPDETRHL VVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK Bacillus subtilis NYSGXRC-6161d SGX Pharmaceuticals 2004-04-22 active Selected Cloned Expressed Soluble Purified EC1494 ICEDB: T1831 GENBANK NP_420302.1 MFAKTYHATHPDMMFAVSNDDLRDRYLMQGLFQDGQIVLTYNHAERFVVGGVVATSPIKLPDQTEPASAAGHPFLE RRELGVINVGDTTGKITVDGVAYEIVPRDGLYVTMGAKDVTFEGVDGAARFYLVSLPAHAAFETKKLAFADAIPL ERGALETSNERTIYQYIVPTTCKSAQLLLGMTVLKPGSVWNTMPPHLHDRRSEAYFYFGLGENDRVFHYMGEPDE MRHIVIANEEAVMSPPWSIHMGSGTANYTFIWAMGGENLDYTDMNVLDICQLK Caulobacter crescentus NYSGXRC-6161f SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble Purified EC1494 ICEDB: T1820 MENRYATSPEDVKRYTTDKLRQEFLVESLFTPGEIQMVYTHFDRTVIGGAIPMKEPLALDAGDFLKTDYFLERREV GIINIGPKGKVIVDGDEYTLNKRDCLYIGLGKRDVSFHSEDSSNPARFYFVSALAHHEYPTKVLPIEEAVPTKLG SDAESNNRTIYKYIHSEGIQSCQLMMGMTLLEPNNMWNTMPAHIHDRRNEVYLYFDMEDDSRVFHFMGQPHETRH LVVKNEQAVISPPWSIHSGVGTANYTFIWAMAGENYTFTDMEFIKMEDLR Bacillus halodurans NYSGXRC-6161g SGX Pharmaceuticals 2005-11-10 active Selected Cloned Expressed Soluble Purified EC1494 ICEDB: T1801 GENBANK NP_457413.1 VDVRQSIHSEHAKTLDTQALRREFLIENIFVADEYTMVYSHIDRIIVGGIMPVSHPVEIGGEVGKQLGVSRLLDRR ELGVINIGGAGAIIVDGQRHDIGHRDALYIGKGAKELVFVSNEASRPAKFYYNCAPAHTAYPTKKVSPADVAPVT LGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYLYFNMEEDSCVFHMMGQPQET RHIVMRNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVQDLR Salmonella typhi NYSGXRC-6162a SGX Pharmaceuticals 2004-03-27 active Selected Cloned EC1839 GENBANK NP_011574.1 MSAVFNNATLSGLVQASTYSQTLQNVAHYQPQLNFMEKYWAAWYSYMNNDVLATGLMFFLLHEFMYFFRCLPWFII DQIPYFRRWKLQPTKIPSAKEQLYCLKSVLLSHFLVEAIPIWTFHPMCEKLGITVEVPFPSLKTMALEIGLFFVL EDTWHYWAHRLFHYGVFYKYIHKQHHRYAAPFGLSAEYAHPAETLSLGFGTVGMPILYVMYTGKLHLFTLCVWIT LRLFQAVDSHSGYDFPWSLNKIMPFWAGAEHHDLHHHYFIGNYASSFRWWDYCLDTESGPEAKASREERMKKRAE NNAQKKTN Saccharomyces cerevisiae NYSGXRC-6162b SGX Pharmaceuticals 2004-03-28 active Selected Cloned EC1839 GENBANK NP_592903.1 MNTTSEVIVGTGFQAIRQQLAQMHPELNFVEQLWLAYYKWFDNDVVATGLMSFLLHELIYFGRCIPWMIIDAMPYF RRWKIQPKKVPTLAEQWECTRLVLLSHFTVELPQIWLFDPMCATFGLSTSVPFPPVTKMIWQITLFFFLEDTWHY WAHRLFHYGIFYRFIHKVHHRYSAPFGLSAEYAHPLEIILLGAGTVFVPLMWCYFTHDLHLVTMYIWITLRLFQA VDSHAGYDFPWSLNKFLPIWAGADHHDYHHMAFKDNFSSSFRWWDAVLKTDQNYHQFKARRLAAKYEAESKKAK Schizosaccharomyces pombe NYSGXRC-6163a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC3370 GENBANK NP_223430.1 MNEIDKSVDIGFLRILDVIKKVKTPKGGIEVLRTLIDFTPKIENALNLATKSHKGQYRKSGEPYIVHPICVASVVA FCGGDEAMVCAALLHDVVEDTPCEIETIEREFGQDVANLVDALTKITEIRKEELGVSSQDPRMVVSALTFRKILI SAIQDPRALVVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIK EYLHKNKQSLLLKLNAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIYLKMQRKGAVNIDEILDLLAIRILLKNP IDCYKVLGIIHLNFKPIVSRFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGV DHEEHHEGMRWLQNFKYHDSDLKNDPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKA TDAYINSKKALLNQELRSGDVVKIIKGDKVIPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGR SVFEDADLKDYKNFEEKLTDCGVETTLTEAMKSFENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFK TNVLNFLTPNRQWQCKELEHFSVCSSNALEIKQVLLNDCCYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAIAEVD AKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLASLLTFLNRNECNIVGVSYLGYKDKYSSHCEVSFEIATDKADWM RALINRKYQDRIVELSSLDDAYELQ Helicobacter pylori NYSGXRC-6163b SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC3370 MIQAYEIAHLIKINDLEKARNIFKKTVENTYKDEFERKSIFKALEIAEQLHYGQYRESGEPYIIHPIMVSLFLAKF QLDFKATIAGLLHDVLEDTNVEKEEIVKEFDEEILSLIDGVTKIHDLHNKTRSIKEANTISKMFFAMTHDIRIII IKLADKLHNMTTLSYLPKNRQDRIAKDCLSTYVPIAERLGISSLKTYLEDLSFKHLYPKDYKEIKNFLSETKIER EKKLYKGKLSIEKELQKSGIEAEITVRSKHFYSIFRKMQTRTNKLTQIFDTLGIRIICKKQKECYEILEIVHRVW KPIPGRLKDYIASPKENKYQSLHTTVRIPEDNQLIEIQIRTEEMDRIANYGVAAHWIYKEQIELKADDLSFINRI KKWQQESANKSQYSMNDIHKELLNTFIYVYTPEGEVVELPFGSNSIDFAYIIHTDIGDQALYAKINGKISSITKP LKNEQIVEIFTSKDSKPDVIWLNSVRTKKARSKIRSWLNKNDNTIFVDNNIIAYLVGANKEQRKLFSLFKSYTKT KIKRIAIDPECSPTTGEDIIGIIHKDEIIVHNENCQKLKSYKKPQLIEVEWEATPTRKVHHIILLLKELKGIFSY LENIFTLNDVRLISEKIEDCGNGHGITNIIVSSNAKNITKIISALKENPNILQIMQIEEDIKNYDN Borrelia burgdorferi NYSGXRC-6163c SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC3370 LAPADVRHHRIGRRAKPYADSMPEPSPVAPSPDPDFGMAELRALIASRPEAERERVEAAYVFARDAHAGVMRKSGE PYITHPVAVAIILARLGMDTDSLMAGLLHDTVEDVEGVTFEVIERNFGPDVRRIVEGETKVSKLSKQGNQQAEVP GDGRDMQAENLRQMLIAMTVDLRIIVVKLADRLHNMRTLGSMKPEKQQRIARETMEIFAPLAHRLGIGRIKWELE DLSFRYLHPDAYEYLQTRLRTRQEERDELIVNAVAELQDALEDDLELLEWVEDIDIAGRSKHLWSIHNKMQKEGK ALEQIFDLLALRVILKPRPLTVPEGVEESRRERAEENREKRVCYHTLSVVHSMWTPLPGRVKDYIAVPKPNGYQS LHTTVISRSGQPIEVQIRSLRMHEVAEYGVAAHWMYKQGGQLAQKDRENWITQLREIQNEIGDASDYIDAVKNDI LSQRVWVFTPKGLAVSLTAGSTPIDFAYHIHTRIGETAVGARVNGSIVPLSHRLQNGDMVEVLTSKQGKPSEDWL NFVATRSARTKIRAYSRQQKRDEGLQKGHDLLERYLRRRQLPVRQLMRSKLLEEAAQKLLGTRNPDELYLALAAG KHTPSAVARILSPTLAQEQAAPSRPRPVAVKSSEHGIYVEGFTTQTKISNCCSPIRGDQIMGYLTRGRGVSIHRI DCPNMVRLLRDEPERCVAASWNATSEEELIVDLDVVAEDRQHLLADVMKVLSDQKTSSLKVAAQADTGGTAHIHL RLAVGSQPQLEVVRSALLAVPNVTDVLRIGRGAKRA Deinococcus radiodurans NYSGXRC-6164a SGX Pharmaceuticals 2004-07-13 active Selected Cloned Expressed Soluble Purified EC1735 ICEDB: T1835 GENBANK NP_371112.1 MADLLNVLKDKLSGKNVKIVLPEGEDERVLTAATQLQATDYVTPIVLGDETKVQSLAQKLDLDISNIELINPATSE LKAELVQSFVERRKGKATEEQAQELLNNVNYFGTMLVYAGKADGLVSGAAHSTGDTVRPALQIIKTKPGVSRTSG IFFMIKGDEQYIFGDCAINPELDSQGLAEIAVESAKSALSFGMDPKVAMLSFSTKGSAKSDDVTKVQEAVKLAQQ KAEEEKLEAIIDGEFQFDAAIVPGVAEKKAPGAKLQGDANVFVFPSLEAGNIGYKIAQRLGGYDAVGPVLQGLNS PVNDLSRGCSIEDVYNLSIITAAQALQ Staphylococcus aureus NYSGXRC-6164b SGX Pharmaceuticals 2004-05-05 active Selected Cloned Expressed Soluble Purified EC1735 ICEDB: T1842 GENBANK NP_269282.1 MSIRSLFGGLREKILGKNMKIVFPEGNDERVVRAAARLKFEGLLEPIILGQSEEVRNLLTKLGFADQDYTIINPNE YADFDKMKEAFVEVRKGKATLEDADKMLRDVNYFGVMLVKMGLADGMVSGAIHSTADTVRPALQIIKTKPGISRT SGVFLMNRENTSERYVFADCAINIDPTAQELAEIAVNTAETAKIFDIDPKIAMLSFSTKGSGKAPQVDKVREATE IATGLNPDLALDGELQFDAAFVPETAAIKAPDSAVAGQANTFVFPDLQSGNIGYKIAQRLGMFDAIGPILQGLNK PVNDLSRGSSAEDIYKLAIITAAQAIESQG Streptococcus pyogenes NYSGXRC-6164c SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC1735 GENBANK NP_110116.1 MSVIDLLKQRVQSAGKKPVIIFPEGSPTVMEAVNQLQQAGILTPPVIFRTRSEVPAGFNTAIKHYVIEEMDLTKYA NFVYEKRKHKGMEMREAQKFVRDASSLAATLVALNEVDGEVCGKEYATKDTLRPALQLLGTGNFVSSVFIMEKNE ERLYFTDCAFAVYPSPQELAVVAENTFKFAQSMGEPELKMVFLSYSTLGSGKGEAVDKVVSATQIFLEKHPELKA NVCGELQFDSAFVEKVRKQKAPNLTWNGSANIYVFPNLDAGNIGYKIAQRLGGYEAIGPIVLGLARPFNDLSRGA SVSDVFNVGIITAAQTLK Mycoplasma pneumoniae NYSGXRC-6165a SGX Pharmaceuticals 2004-02-23 active Selected EC2475 VTDLAGTTRLLRAQGVTAPAGFRAAGVAAGIKASGALDLALVFNEGPDYAAAGVFTRNQVKAAPVLWTQQVLTTGR LRAVILNSGGANACTGPAGFADTHATAEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKLLAGVAHVVHEMH GGLVGGDEAAHAIMTTDNVPKQVALHHHDNWTVGGMAKGAGMLAPSLATMLCVLTTDAAAEPAALERALRRAAAA TFDRLDIDGSCSTNDTVLLLSSGASEIPPAQADLDEAVLRVCDDLCAQLQADAEGVTKRVTVTVTGAATEDDALV AARQIARDSLVKTALFGSDPNWGRVLAAVGMAPITLDPDRISVSFNGAAVCVHGVGAPGAREVDLSDADIDITVD LGVGDGQARIRTTDLSHAYVEENSAYSS Mycobacterium tuberculosis NYSGXRC-6165b SGX Pharmaceuticals 2004-04-08 active Selected Cloned Expressed Soluble Purified EC2475 ICEDB: T1765 MAEILMGVGNAGLKESGNPDILVVYLPYPCTASFVFTDNYFKAGSVIYSERIARDKERIRAFVVNSGNANCGTGEE GIKHAEMMAEKVAQILDIPKDEVFVFSTGIIGKYLPIENVLKGIEQACSNLELLDLKRASEVISTTDRFPKYDFA KAGEVETFGFAKGAGMIHPSMATMLAFVFTNANLEYLTLKRIHESVTEKTFNSITVDGCESTNDAFGIISLGEVE ADPETVEFELLKVSESLAKQIVADGEGATKIIRVNVRSAITEIKAREIAEAIANSLLVKTAVFGRDPNWGRIAAA AGSTEFPIDPFKLEIYVGGYLLYDGKPHDENLEKAKKHLIEDREVDITVELNEGEYEWVCYSSDIGYDYIKLNAE YTT Aquifex aeolicus NYSGXRC-6166a SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC2656 MRRSFLKTIGLGVIALSLGVVSPLSAASYPPIKNTKVGLPLSSHPLASEIGQKVLEDGGNAIDAAVAIGFALAVVH PAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYG TKKLSQLIDPAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTL GAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIVSMSPPSSGGTHLIQILNVMENADL STLGYGASKNIHIAAEAMRQAYADRSVYMGDSDFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHE GSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLS SMSPTIVLKNNKVFMVVGSPGGSRIITTVLQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDN LTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGSTDPRKEF Helicobacter pylori NYSGXRC-6166b SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC2656 MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDG GDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFF NSGIGGGGYVVFSGKDDEDHLSIDFREKAPMDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDW RDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSV APFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAAL RIMDNFQNQEGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKT LENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAP SIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDR IELESFPMIGKAVLSTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY Saccharomyces cerevisiae NYSGXRC-6166c SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC2656 MMRPTVFSSKAVISSSSLSASLAGAKIIEKGGNIFDAAIAVSSVLSVTQNNLCGLGGDAFALVRYNGRVKGYNGSG KSSRNVNRGLYFELGYSRIPERGIYSAITVPGLVDLWNSLYLEYATMRFSDLISDAIKYAETGFYITRHYEESLI ASSPILGQYNWSNQFMPYGKIPAEGDLFIQKDLAGTLREIAEEGPRSFYDGYLSDIIFKAMEKTNLLIDSKDLSD HKTLAANPVKSTYMDYDVFETAPNSQGATVNYWLALLEQKIQNKIPRPVDIVESGLEAYRWRSMFIGDPERMPFN GDLLSKGAGPYYNNPRVPEDKGDTTYFSISDANGNSISMIQSNYMGFGSGIIPEGTGFVLQNRGSYFTLDDKHHN SLEPRKRTFHTLAACIIEKDGELVYSLGTMGGDIQPQVQVQIITGLINQDLMPQEAIERPRWAFPATIYEQPSVL NVEDTSLINENETRLRINPMKYSSSFGTAQVTALLNGRVAGGSDPRGDGFSIPV Thermoplasma volcanium NYSGXRC-6166d SGX Pharmaceuticals 2006-10-20 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC2656 ICEDB: T1863 PDB 2NLZ PFAM PF01019 GENBANK NP_241733.1 VSVMFDPQSYPYPSRRNVVYAKNGMVATSQPLAAQAGLDILKAGGNAIDAAIATATALTVLEPTSNGIGSDAFALV WTKGKLHGLNGSGRAPMSLTMEAVKAKGYEQELPPYGVIPVTVPGAPGAWAELAKMYGNLPLAASLAPAIRYAEE GYPVTPTLAKYWKAAYDRFKTEWTDDVYQPWFDTFAPKGRAPRVGEVWRSQGHADTLRSIAESNGESFYRGELAD QIHAFFDKHGGYLTKEDLACYRPEWVEPISIDYRGYRVWEIPPNGQGLVALEALNIVKGFEFYHKDTVDTYHKQI EAMKLAFVDGMKYVTEPSDMSVSVEQLLSDEYATERRKEIGEQALTPEPGTPPRGGTVYLATADGDGNMVSFIQS NYMGFGSGVVVPGTGIAMQNRGHNFSLDPNHDNALKPGKRTYHTIIPGFLTKNDQPIGPFGVMGGFMQPQGHMQV MMNTIDFGLNPQAALDAPRWQWTNGKQVQVEPTFPVDIAQALVRRGHKIQVVLDEGAFGRGQIIWRDPTTGVLAG GTEPRTDGQVAAW Bacillus halodurans NYSGXRC-6166e SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC2656 MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNASGRSPS AWTPEYFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFAS QPGFADAFMPGGRAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVD TITGTYRGYTIHQIPPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHPK RLLDKEYLRQRATLIDPKRAMPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDF TVVPRHPNRVGPRKRPYHTIIPGFVTRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNG MRVSFENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC Mycobacterium tuberculosis NYSGXRC-6166f SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC2656 VPLWRIRPMKMRFLSEAFLALMLSTAITSAQQASDTVAPEKATAVATARRVESRSFMVAAANPLAAEAGRDVIAAG GNAIDAMVAVQTVLGLVEPQSSGLGGGAFLVYYHAKNGKLTTLDGRETAPMDATPKLFLDDKGQPLKFMDAVVGG RSVGTPGTVRLLEEAHKRYGKADWASLLKPAETLATEGFKVSPRLASLIASEGDRLKKYPEARSYFFDTSGAALQ TGALLKNPAYAETLATLAKSGADAFYKGRIAEAVVKTVREATDNPGVLSLSDLSNYRVIEREPVCFIYRALDVCG MGPPSSGGIAIGQMLGMAESFDLKSLGPKNVESWRLIGDAQRLAFADRERYVADTDFVPLPIKGLLDKTYLGERA KLLDGDRALAKDAVKAGEPEWDHALLFGRDAALELPSTSHFVIVDKEGNVVSMTTTIESGFGSRLMTNGFLLNNE LTDFSFKTHDGGLPIANRVEPGKRPRSSMAPTIVMKDGKPLLAIGSPGGSQIIGYVAQALIAYIDWGMPVEAIVA QPHLINRFGTYDIEAGTSAEDLVEPLKALGYEVKPGELNSGLHAIEITAQGLAGSADPRREGAVMGE Agrobacterium tumefaciens NYSGXRC-6166g SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC2656 GENBANK NP_146992.1 VAKASAESLGGTVASEESIASYIGAGILSSGGNAVDAAVATSLALTVLIPHLGGVGGDFFMLYRSPEGRVFFVNGS GFAPRRLTREEVLGRGLQEIPESGPLSPTTPGYLAGLYHSWRSFGTMEWASLVKPARLLASRGFPLPPSTARSLK LRRECLEADPGSREAVLKTLPREEGSPARLPGLAALLSGVEEDPLYLYQGEPAEALEEYLASIGGVMGAEDLAGT RGFTAEPLYSEYRGWKVWEMPPNTQGVTTLHLLMLLEEEELPEPFSPERVDILAGLARMAYSIRDRYVGDPRYMP IDPHELARKETLLKLLGQEESNGSKATGDTTFFAVADREGGIVAGIQSLFYPWGSCVTEPRFQVTLNNRARGFTL KEGLPSTLRPGAFPLHTLSSVIMEQRERVIALGASGGHLRPQQHALFVTNIVDYGMNVLDAINAPRAVWDPGRGE ILCEEGFGCRPSWRKVERIGVANAVEVAGSVKRGYTDMRGDGLPAVAP Aeropyrum pernix NYSGXRC-6166h SGX Pharmaceuticals 2004-03-30 active Selected Cloned Expressed EC2656 GENBANK NP_229851.1 MEMGMNWTHTPLALSALMFAMAAQATPNQATDAVAPEQATGFEHKSLVKAKNWMVTAANPLASEAGASILRQGGNA IDAMVTTQLMLGLVEPQSSGIGGGSFLVYWDAKKKALTTFDGRETAPLNATPELFLDSTGQPMKFYDAVVGGRSV GTPGTVKLLWETHRQYGKLEWARLIEPVAKLAEQGFEVSPRLAALIAEDKERLGRFPATKAYFFDAQGEPLTAGT LLKNPDYAATLRAIAQQGASAFYQGDIAKDIIATVQNAPGNPGVLAQQDFDTYQVKQRAPVCAAYQSYQVCGMGL PSSGGLTVGQILALTEQYDLKGWGAQDVKSWQVLGDASQLAFADRGLYMADQDYVPVPTQGLLDKTYLAERAKLI QPGKALTSAPAGNPPWHHAQLRSPDQSIELPSTSHFNIVDREGNVVSFTTSIENAFGSRLLVRGFLLNNELTDFS FATQSEGRPIANRLEPGKRPRSSMAPTIVLQDNQPYLAIGSPGGSRIIGYVAQAIVAHTQWGMNIQAAINQPHVL NRFGEIELEQGTSAEQFKPALESLGAKVGIKELNSGLHAIRITAQGLEGAADPRREGVAIGE Vibrio cholerae NYSGXRC-6166i SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC2656 GENBANK NP_274091.1 MPCMNHQSNSGEGVLVAKTYLLTALIMSMTISGCQVIHANQGKVNTHSAVITGADAHTPEHATGLTEQKQVIASDF MVASANPLATQAGYDILKQGGSAADAMVAVQTTLSLVEPQSSGLGGGAFVLYWDNTAKTLTTFDGRETAPMRATP ELFLDKDGQPLKFMEAVVGGRSVGTPAIPKLMETIHQRYGVLPWGKLFDTPIRLAKQGFEVSPRLAISVEQNQQH LARYPKTAAYFLPNGVPLQAGSLLKNLEFADSVQALAAQGAKALHTGKYAQNIVSVVQNAKDNPGQLSLQDLSDY QVVERPPVCVTYRIYEVCGMGAPSSGGIAVGQILGILNEFSPNQVGYDAEGLRLLGDASRLAFADRDVYLGDPDF VPVPIRQLISKDYLKHRSQLLEQSDKALPSVSAGDFIHEWVSSQAIELPSTSHISIVDKAGNVLSMTTSIENAFG STLMANGYLLNNELTDFSFEPIKQGKQVANRVEPGKRPRSSMAPTIVFKAGKPYMAIGSPGGSRIIGYVAKTIVA HSDWNMDIQNAISAPNLLNRFGSYELETGTTAVQWQQALNDLGYKTDVRELNSGVQAIIIEPSRLVGGADPRREG RVMGD Neisseria meningitidis NYSGXRC-6166j SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC2656 GENBANK NP_370733.1 MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSI TAFDARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHA ANWATEKYSRQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKAC GGTIILEDLANYDIQIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHLA YSDRAQYLADDNFHEVPVQSLIDDDYLKARSTLINSNKANIDIEHGVVSDCISHTDVEENHTETTHFCVIDKEGN IASFTTSIGMIYGSGITIPGYGVLLNTTMDGFDVVDGGINEIAPYKRPLSNMAPTIVMHHGKPILTVGAPGAISI IASVAQTLINVLVFGMDIQQAIDEPRIYSSHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDLN TRDASGGADDTREGTVIGGDVLSIRKQPLPSPKIYDNDTHRVYFNDMQLPLYAEQVRWMHDKYWVDESVIRIIFP EVSVHIEDLRSYEIAGKNYIDIAWLARKKGYQVTLKDDSLYLTDETYHSVKANTNAYYRYDRDSITR Staphylococcus aureus NYSGXRC-6167a SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC3181 GENBANK NP_208206.1 LSIYKDINIASAKPSLKERKNIKHYALDHLNIDEKNNAPLFKTLLEDAMRVSSKEILLIVGGSSFYLKSILEGLSR MPKLSGEEVVKIEREIATLSNPYIFLKSIDPNMAFKIHPNDTYRTHKALEIFYATCTPPSEYFKANPKKPFEHAI SLFALSIEKSALHNNIKRRTKNMLHSGLVEEIKALYTQYPKDSQPFKAIGVKESVLFLEKRLTLKELEEAITSNT MKLAKRQNTFNKTQFNNLYVGSAEEVRHAILKHSKSGIKG Helicobacter pylori NYSGXRC-6167b SGX Pharmaceuticals 2004-06-24 active Selected Cloned Expressed Soluble EC3181 GENBANK NP_489306.1 MTKLIVICGATATGKSGLALNLAMRLGSVILSADSRQVYREFDIGTAKPTLAEQRAVPHYLIDICAPRETMTVADY QEQAQALINSLPVSPLLLVGGTGLYIRSIVQGMKIPRVAPNYELRSQLASLGQTTLYGILQQVDPIAAQKIHPND PVRTLRAVEVFYITGIPISAQQGENPPDYPILQIGLDCEMERLTERIHKRTEQMITDGLVGEVEYLCQKYGAELP LLNTLGYQEIKQYLTGEISLEAAKELTVLHTRQFAKRQRTWFRASPQIEWFNADHPDLLDIVCQHIQQP Nostoc sp. NYSGXRC-6168b SGX Pharmaceuticals 2004-05-05 active Selected Cloned Expressed Soluble Purified EC816 ICEDB: T1845 GENBANK NP_342373.1 PFAM PF00696 MALIVKIGGSIQKDEKDYELIVKKIQDFSKKSDKIIVVTSAIKNVTNELISATSNTDNSPNIVTEIYERHIKLLSK LADGKEFENSFKDISRLSDELFRVAWSIRVLDEVTPRVRDYILSFGERMATLLLSAILRSNGIEAEGIITPPFLT DENYGEANVIEDLSKNEIANILENAKANVIVLPGFIGRTREGRYTTLGRGGSDYTATLLGKLVGVREVRLVTEVP GIMTGDPKKFENAKTISRLSLEEAIELSQLGAKRLHPRTFDPVFGSDMKVIVESLYEDGFTIINGECQNNDGLKG ISLLDNAKLITVESTKIVGKIGSAARITNEAKEAGVNIISISQPASETTIQLVVDSLSANRLLSKLEEIRGTLVK DIEVNDINIVGIVGCGIKKKEISTKVLSIASSYDPLAISRGISNVSMTFIVNKDEGEKLAKELHKVIVSG Sulfolobus solfataricus NYSGXRC-6168c SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble Purified EC816 ICEDB: T1839 GENBANK NP_596542.1 MSIAKNIENDPSKGWVVQKFGGTSVGKFPIKIAVDVAKEYLSTKRVALVCSARSTDTKAEGTTTRLIRATEAALRP AVGSVHDLVRIIETDHVQAARDFIQDVGIQDELIDAFHADCVELEQYLNAIRVLSEVSPRTRDLVIGMGERLSCR FMAAVLKDQGIDSEFIDMSHIIDEQREWRNLDASFYAYLASQLASKVTAVGNKVPVVTGFFGMVPGGLLSQIGRG YTDFCAALLAVGLNADELQIWKEVDGIFTADPRKVPTARLLPLITPEEAAELTYYGSEVIHPFTMSQVVHARIPI RIKNVGNPRGKGTVIFPDTISRHGSATPPHPPKIMPDDISASLANKGATAVTIKDTIMVINIQSNRKISAHGFLA SIFAILDKYKLAVDLITTSEVHVSMALYEESDDGNMHEAFVELRRLGTLDILHGLAILSLVGKHMRNTTGYAGRM FCKLAEAQINIEMISQGASEINISCVIDEKMAVKALNVIHKELLEPLALHEVPSQASMLVEKPWLYSA Schizosaccharomyces pombe NYSGXRC-6169a SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC3880 MQGFLRSLFFGVKKIPKRFAPLVEKGVLKEALQSNKDRYLLKEGFDIGKIERVKNKAFFISLAKNYPKDPLIKNLP PSFKTDALILCQIECSKKRPIAFFKAALLNADHAMIAYLAKEKNQIVAIPFKEPFKKPISLKHSQRSLLELPRHC VVKIDLKKREISEILGALEDPLIDENLSLSLFDRIKDFSKDCLDLAQYYAQLKASDFKDRINYSHIPFITIDPKD AKDFDDAIFYDKEKNTLFVAVADVSEFVPKHSSLDKEARIRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLAL VYEIPLDNLKNARLSQGVIEVRANCAYEEINHFLNTQQSSLGKDLQQSLLGFLEVALKLKKERLKKGFNFNSFEN KLYLNEEGRIEKIETEKESGAHTLIEEAMLLANQSSARLLDGHFHNRGIYRTHKEPSLEQQKRLYDKLFDYEIVR PKNMGFFPFLEHALKISQEKSIEREVSRLIIKSQNLALYSPMQESHFGLGFASYTHFTSPIRRYSDLALHRLLKE LLFHQAKGCSYLLEETPELCAELNALQKKAALIERDFIKRKFARLALEFLEKEFLGVVLEAKDWVVVGLKEFIGL KVLIKTNKVFKPLEKVRIKITHADLILGQVRGEITERIKEHVS Helicobacter pylori NYSGXRC-6169b SGX Pharmaceuticals 2004-07-13 active Selected Cloned Expressed Soluble Purified EC3880 ICEDB: T1834 GENBANK NP_905829.1 MTKEEMRNAILDIFQSNPQSVMNYKQVSHLMGVEAAPQKLMVNSLMEDMAVDDILHEIERGRYRYNALGLIVIGTF ERRFNGRNSFIPEGGGTPIFIAERNSAHAMDGDKVKVQLFAKRRGRAPEAAVIEIIEQKQATFVGKIQINRDFAF LVTEDRTLANDIFIPKDNLGNAKNGDKVIVRILEWPEQSKNPIGEVQAVLGPAGDNDAEMNAILAEFGLPYVYPQ EVEEAADRLDGKITEEELARREDFRSILTFTIDPKDAKDFDDAISFRPLEDDCYEVGVHIADVSHYVTEGGIIDQ EAYNRATSIYLVDRTIPMLPERLCNDLCSLRPDEEKYAYSCIFRMNDEAKVLDYRICHSVIKSDRRFAYEEAQAV IETGEGDCKEAILKLNELAQRLRKERFQNGAIAFERKEVRFEIDEKGRPLGVIVKESKEANKLIEEFMLLANRTV ARHIGEETQGKRAKTFVYRIHDLPDPDKLETLSDFIRRFGYKLRTTGSNVEVSKSINSLLDNIQNKPEENLISTV AIRSMAKAIYSTDNIGHYGLAFDFYTHFTSPIRRYPDLMVHRLLTKYLSGGSSVDKNDYEEKCKHSSAMEQLAAS AERASIKYKQVEFMSEHLGKVFDGVISGVTEWGLYVELKENMCEGLIPIRCLDDDYYEYDDKNFCLIGRRYRHRY SLGDAITVRVAQANLDRKQLDFEPVS Porphyromonas gingivalis NYSGXRC-6170a SGX Pharmaceuticals 2004-05-04 active Selected Cloned Expressed Soluble EC4287 GENBANK NP_372573.1 MTKDILILAVETSCDETSVSVIKNGRDILSNTVLSQIESHKRFGGVVPEVASRHHVEGITTTINEALVDADVSMED IDAIAVTEGPGLIGALLIGVNAAKALAFAYDKPLIPVHHIAGHIYANHIEEPLTFPLIALIVSGGHTELVYMKDH LSFEVIGETRDDAVGEAYDKVARTIGLNYPGGPQVDRLAAEGEDTYSFPRVWLDKDSYDFSFSGLKSAVINQLHN QRQKNIPIIEANVATSFQNSVVEVLTFKAIQACKEYSVQRLIVAGGVASNKGLRQSLADQCKVNDIQLTIPSPKL CTDNAAMIGVAGHSLYQQGRFADLALNGHSNIDLEEYSAE Staphylococcus aureus NYSGXRC-6170b SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC4287 GENBANK NP_484154.1 MTTVLAIETSCDETAVAIVNNRQVLSSIIASQISVHQQYGGVVPEVASRAHLETINGAIAQAMDQAQLGWDKIDAI AATCAPGLVGALLVGLTAAKTLAILHNKPFLGVHHLEGHIYATYLSEPTLDPPFLSLLVSGGHTSLIYVKECGRY ESLGETRDDAAGEAFDKVARLLKLGYPGGPVIDKLAQTGNPQAFALPEGKVSLPGGGYHPYDGSFSGLKTAVLRL VQQLEKDGDSLPLEDIAASFQATVAKALTKRAIACALDYGLDTIAVGGGVAANSGLRQHLQAATAANNLRVLFPP LKFCTDNAAMIACAAVDHLSRGHTSPITLGVESRLSLSQVMKLYQ Nostoc sp. NYSGXRC-6170c SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC4287 GENBANK NP_269865.1 MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDL SAVAVTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPG DYHIIGETRDDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNA KQKGDELILEDLCASFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGD NAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN Streptococcus pyogenes NYSGXRC-6170d SGX Pharmaceuticals 2004-08-05 active Selected Cloned Expressed Soluble Purified EC4287 ICEDB: T1851 GENBANK NP_231623.1 MSVKILALDTATERCSVALLVGNTVYSRSEIAPRDHTKKVLPMVDEVLKEAGVTLQELDALAFGRGPGSFTGVRIG IGIAQGLAFGADLPMIGISTLAAMAQAAYRLQGLTHVASAIDARMEEVYWGRYVRQEDGSWQVAEAECVIAPALL AQTLTQDDLTQDEQIWATAGTGWDAYPALADLPLQLQTSEVLYPDAQDMAYLAQFELAQGNKVSVEQASPVYLRD TVAWKKLPGRE Vibrio cholerae NYSGXRC-6170e SGX Pharmaceuticals 2004-04-23 active Selected Cloned Expressed Soluble Purified EC4287 ICEDB: T1830 GENBANK NP_282490.1 MKNLILAIESSCDDSSIAIIDKNTLECKFHKKISQELDHSIYGGVVPELAARLHSEALPKMLKQCKEHFKNLCAIA VTNEPGLSVSLLSGISMAKTLASALNLPLIPINHLKGHIYSLFLEEKISLDMGILLVSGGHTMVLYLKDDASLEL LASTNDDSFGESFDKVAKMMNLGYPGGVIIENLAKNAKLKNISFNTPLKHSKELAFSFSGLKNAVRLEILKHENL NEDTKAEIAYAFENTACDHIMDKLEKIFNLYKFKNFGVVGGASANLNLRSRLQNLCQKYNANLKLAPLKFCSDNA LMIARAAVDAYEKKEFVSVEEDILSPKNKNFSRI Campylobacter jejuni NYSGXRC-6170f SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble EC4287 GENBANK NP_274799.1 MLVLGIESSCDETGVALYDTERGLRAHCLHTQMAMHAEYGGVVPELASRDHIRRLVPLTEGCLAQAGASYGDIDAV AFTQGPGLGGALLAGSSYANALALALDKPVIPVHHLEGHLLSPLLAEEKPDFPFVALLVSGGHTQIMAVRGIGDY ALLGESVDDAAGEAFDKTAKLLGLLYPGGAKLSELAESGRFEAFVFPRPMIHSDDLQMSFSGLKTAVLTAVEKVR AENGADDIPEQTRNDICRAFQDAVVDVLAAKVKKALLQTGFRTVVVAGGVGANRKLRETFGNMTVQIPTPKGKPK HPSEKVSVFFPPTAYCTDNGAMIAFAGAMHLGKGREVGAFNVRPRWPLSEIVR Neisseria meningitidis NYSGXRC-6170g SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC4287 MILSIESSCDDSSLALTRIEDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKIKAI AITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKQTCMPLSVLLVSGGHSLILEARDYENI KIVATSLDDSFGESFDKVSKMLDLGYPGGPIVEKLALDYRHPNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEVEK NAPNLNEAIKQKIGYHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCDAFDCKLVLAPLEF CSDNAAMIGRSSLEAYQKKRFVPLEKANISPRTLLKSFE Helicobacter pylori NYSGXRC-6170h SGX Pharmaceuticals 2004-06-24 active Selected Cloned Expressed Soluble EC4287 GENBANK NP_577901.1 MIALGIEGTAHTLGIGIVTENKVLANVFDTLKTEKGGIHPKEAAEHHAKLLKPLLRKALEEAGVSMEDIDVIAFSQ GPGLGPALRVVATAARALAIKYNKPIVGVNHCIAHVEITKMFGVKDPVGLYVSGGNTQVLALEGGRYRVFGETLD IGIGNALDVFARELGLGFPGGPKIEKLALKGEKYIELPYAVKGMDLSFSGLLTEAIRKYKSGKYRVEDLAYSFQE TAFAALVEVTERALAHTEKEEVVLVGGVAANNRLREMLRIMAEDRGVKFFVPPYDLCRDNGAMIAYTGLRMYKAG IKFKLEETIVKQKFRTDEVEVVW Pyrococcus furiosus NYSGXRC-6170i SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC4287 MCKDIKILAIESSCDETAAAVVVNGRKVLSNIISSQIDIHKKFGGVVPEIASRKHIENISLVVQDAIKEAGVELKD IDAVGVTYGPGLVGALLVGLQYAKGLAYSINKPLIGVNHIEGHISANFIQYPDLKPPFACLVVSGGHTFIVYMKD YGEFEVLGQTRDDAAGEAFDKIARAIGLGYPGGPKIQEMAKRGDESALQFPRAKFHDNSLDFSFSGVKSAVLNYL NTMKMQEKEINRADVAASFQKNVVDFLVDNTIKACKIKKIDRIAVAGGVASNSFLRETMVSRGRENGIDVLFPAP ILCTDNAAMIGSAAYFEFKKGNIAPLDLNAIPNLKLGER Clostridium acetobutylicum NYSGXRC-6171a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC3753 GENBANK NP_216793.1 MVKTAMLGAVALVIALGGTCGVADALPLGQTDDPMIVAHRAGTRDFPENTVLAITNAVAAGVDGMWLTVQVSSDGV PVLYRPSDLATLTDGAGPVNSKTVQQLQQLNAGWNFTTPGVEGHPYRQRATPIPTLEQAIGATPPDMTLFLDLKQ TPPQPLVSAVAQVLTRTGAAGRSIVYSTNADITAAASRQEGLQVAESRDVTRQRLFNMALNHHCDPQPDPGKWAG FELHRDVTVTEEFTLGSGISAVNAELWDEASVDCFRSQSGMKVMGFAVKTVDDYRLAHKIGLDAVLVDSPLAAQQ WRH Mycobacterium tuberculosis NYSGXRC-6171b SGX Pharmaceuticals 2004-02-23 active Selected EC3753 MVVAHRGCHAAAPDHGLASSAPENSLEALQRCIDIGVDMVETDVRRTQDGVLVIMHDPSVDRTTDGGGLVAKLTLA QIQALRLDGGDEAPPTLEAFLRAARGRVLVNLHLKGPFAAQAAEVARRADASDWVLFKARAKTDMSPIADQPLYR DVAFMPMVGEGAARDAGQLGQVITRQASGIRPIPAVETRRMGAQGFASVRDAAEAARVRVWANTLGMSSWKSFFG VSGDRRALRDPDTSWGRLIDQGVSIIQTDHPARLLGYLKSRRLRDGVTIATIGEASPSSTTHAALAGTR Caulobacter crescentus NYSGXRC-6171c SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble Purified EC3753 ICEDB: T1819 LQRPKVKTMHQTLATSRKTSNACNVLALCTRDNPAILTIAHRGFWTATAENSLASVRAAVAAGVEMIEIDTQATAD GRLVVIHDETLDRTTTGKGTVSALPFEVVRAAKLKAGAGGDGADVTDECVPTLEEVLEEARGRITVNIDTKFTRD LPQVMETVLRLGVEDQVLVKTDVDPEAERFEVLGSHWFGRIPHMPMFPVRKGKFAEDLRRIEALKAPMIEVKFTD IADLAEGRAEMERQNIRLWINSLDVSHCLDFNDTRALSNPEAVWGALAEAGTGAIQTDEVEAFTAWLKAGAGETG RAWTR Agrobacterium tumefaciens NYSGXRC-6171d SGX Pharmaceuticals 2004-04-13 active Selected Cloned Expressed Soluble Purified EC3753 ICEDB: T1883 GENBANK NP_295807.1 MSKIWFGALALLLMGCATPVASAPNPYLTGRTLNIAHQGGEALWPSNTLTAYRGAVALGVDLLEMDLHATRDGALV LSHDATLDRLTDTQGRIADLTLEQVLRADAGYTLTPAGGSGFPFRGQGVQVAQLKDVLREFPNTPLIIELKQASP SIAAPFCAELRRAGATGRVIAASFSDAALNEFRRLCPEVMTSMTERELRPLVLLSKVGLSALAPTPGQVAQVPVR SGGIEIVTPAFVRALHARGVAVQVWTIDDEAEMRRLVQMGVDGVITNRPDLLKKVLAER Deinococcus radiodurans NYSGXRC-6171e SGX Pharmaceuticals 2004-03-30 active Selected Cloned Expressed EC3753 GENBANK NP_393727.1 MIKLYDNYVFISQEGGESGERLYSKKFREKSVVDVSGLRIGEGLVVAAGPCSVENEAMILDIARSVKAAGADMIRG GAFKPRTSPYSFQGLAEKGIEYLVEAREETGLPIVTEIMNPEYYRYFDRVDMLQVGSRNAQNFDLLRFLGKQKKP VLLKNGMGNTAREWLETAEYILSGGNGNVVLCYRGVRGIENSTRFTMNVGSIIYAKSETHLPICADPSHASGRRD FVESMALASVAAGADMLEIEVHNDPDNALSDSEQQIRPVDLKRIIEKARALKDLLSHEI Thermoplasma acidophilum NYSGXRC-6171f SGX Pharmaceuticals 2004-03-30 active Selected EC3753 MNRSIAILLLGLSLSGCVEARSVVPADGPGPLLVAHRAGTADYPENTLLAIRKALDNGADALWLSVQLSADGHPVL YRPADLAVLTQGAGAVGQSSLAELARLNAGYMFKAEDGSYPYRQKPLRIPTLRQALRAIPPQVPVFLDMKSLPVE PLVDAVAGELERQKAWSRVRFYSTEKAANDYLTQRYADRARQFESRDATRNRLVGLAFGERCEAPPAGGTWMGIE LRRELTVTERFTLGESSYKVPAAQLWTRKAMDCVRREPVKVVMFGIETAEDYRTARTLGADAVMSNSPRKMEAIR RRVLADQPGG Pseudomonas aeruginosa NYSGXRC-6172a SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC2572 GENBANK NP_217858.1 MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPT PGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVA AVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLA RRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGV SAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGA CRR Mycobacterium tuberculosis NYSGXRC-6172b SGX Pharmaceuticals 2004-03-09 active Selected EC2572 MTEFIPPGSLFHALSSPFPMKRGGQLHRARIAYETWGHLNASATNAILIMPGLSPNAHAAHHDSNAEPGWWESMLG PGKPIDTDRWFVICVNSLGSCKGSTGPASYNPITQAMYRLDFPALSIEDGANAAIEVVHALGIKQLASLIGNSMG GMTALAILLLHPDIARSHINISGSAQALPFSIAIRSLQREAIRLDPHWNQGHYDDTHYPESGLRIARKLGVITYR SALEWDGRFGRVRLDSDQTNDTPFGLEFQIENYLESHAHRFVHTFDPNCYLYLSRSMDWFDVAEYANGDILAGLA RIRIQRALAIGSHTDILFPIQQQQQIAEGLRRGGTHATFLGLDSPQGHDAFLVDIAGFGPPVKEFLDEL Xylella fastidiosa NYSGXRC-6172c SGX Pharmaceuticals 2004-05-11 active Selected Cloned Expressed Soluble Purified EC2572 ICEDB: T1913 GENBANK NP_518148.1 MTELQVDPAASADPAAAADTPRHPAATLPPDSVGLVVPERMHFAEPLPLRNGSQLVGYDLMVETYGTLNAERSNAV LICHALNASHHVAGVHAEGEVGWWDNMVGPGKPVDTNRFFVIGVNNLGSCFGSTGPMSPHPQTGQPYGARFPVVT VEDWVNAQARVADRFGIRQFAAVMGGSLGGMQALAWSLMYPERVRHCVVVASTPKLSAQNIAFNEVARSAILSDP DFHGGDYYAHNVKPKRGLRVARMIGHITYLSDEDMAEKFGRELKAEDIRFSFDVEFQVESYLRYQGDKFAEYFDA NTYLLITRALDYFDPALAYEGSLTRAVAHTRASYLVVSFTTDWRFAPARSRELVKALLDNKRPVTYGEIDAPHGH DAFLLEDARYHALVRAYYERIAQEIGA Ralstonia solanacearum NYSGXRC-6172d SGX Pharmaceuticals 2005-05-06 active Selected Cloned Expressed Soluble Purified EC2572 ICEDB: T2207 GENBANK NP_273978.1 MSQNASVGIVMPQKIPFEMPLVLENGKTLPRFDLMIETYGELNAEKNNAVLICHALSGNHHVAGRHSAEDKYTGWW DNMVGPGKPIDTERFFVVGLNNLGGCDGSSGPLSINPETGREYGADFPVVTVKDWVKSQAALADYLGIEQWAAIV GGSLGGMQALQWTISYPERVRHALVIASAPKLSTQNIAFNDVARQAILTDPDFNEGHYRSHNTVPARGLRIARMM GHITYLAEDGLGKKFGRDLRSNGYQYGFGVEFEVESYLRYQGDKFVGRFDANTYLLMTKALDYFDPAADFGDSLT RALQNVKAKFFVASFSTDWRFAPERSHELVKALIAAQKSVQYIEVKSAHGHDAFLMEDEAYMRAVAAYMNNVYKE CQQ Neisseria meningitidis NYSGXRC-6172e SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble Purified EC2572 ICEDB: T1822 MAALDPITPAGGGTWRFPANEPLRLDSGGVIEGLEIAYQTYGQLNADKSNAVLICHALTGDQHVASPHPTTGKPGW WQRLVGPGKPLDPARHFIICSNVIGGCMGSTGPASINPATGKTYGLSFPVITIADMVRAQAMLVSALGVETLFAV VGGSMGGMQVQQWAVDYPERMFSAVVLASASRHSAQNIAFHEVGRQAIMADPDWRGGAYAEHGVRPEKGLAVARM AAHITYLSEPALQRKFGRELQRDGLSWGFDADFQVESYLRHQGSSFVDRFDANSYLYITRAMDYFDIAASHGGVL AKAFTRARNVRFCVLSFSSDWLYPTAENRHLVRALTAAGARAAFAEIESDKGHDAFLLDEPVMDAALEGFLASAE RDRGLV Caulobacter crescentus NYSGXRC-6172f SGX Pharmaceuticals 2004-03-29 active Selected Cloned EC2572 GENBANK NP_595166.1 MLRASSKRLQLSWQVFRRFQSSNPQLSFPCVDQAQERSRQFEQSLQKQQACPNSVDPSASITSPSLSSGPEPVYGK IVSGFKKFYHNKPFLCDHGGILPKFEIAYETWGTLNKDHSNAILLHTGLSASSHAHSHPENTAPGWWEQFIGPGK DVDTNKFFVICTNVLGSCYGSTGPSSVDPGDGKHYATRFPIITVNDMIRAQLLLLDHLKIEKLYASVGSSLGGMQ SLTLGALAPHRVGRIASISGGARSHPYSIALRFTQRQILMNDPYWNRGFYYDGVPPHTGMKLAREVATISYRSGP EWEQRFGNRRADPSVSPAFCPDFLIETYLDHAGEKFCLQYDPNSLLYISKAMDMHDMSASHQRSLSENRKKNQHK LDKYLSADVSAEEIIKLNEDTSVLPDVPYQEIANEDRAPEPDPETNLIAGLAPLKDTPVMVMGVESDNLMPVECQ RETARCLEKAGNKQVVYHELDANESFYGHDTFLIYRKDLDLVGGKLKKFLELS Schizosaccharomyces pombe NYSGXRC-6172g SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble Purified EC2572 ICEDB: T1837 GENBANK NP_014122.1 MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTG SADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLG VKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVA GLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKG QSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLAR DRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTN CKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW Saccharomyces cerevisiae NYSGXRC-6172h SGX Pharmaceuticals 2004-02-23 active Selected EC2572 MAAALAVIAVHNTVAKNYYQVCTDGGPMPTTELDGFTFACGDTVDSLTVAYRTYGDYTGSNAVLVCHALTGSQHVR GRADGDDRGWWPDIVGPGRPIDTTEYFVVCANVPGSCHGTDGPPADGPGGDPWGTAFPPVTVPDWTRCQRRLLDT LGVDRLHAVVGGSVGGMNALDWARRYPDDVHRIAAVATAPRLDAQCLGLNAIARRAIRGDPNWNDGDYYGGAHPD RGLALARQLGHVMYLSKASMADKFGRRTATTDTALPADPAAEFFATRDVESYLDYQADTFVARFDANSYLYLLRA MDAYDLAAGRPSVADALAAFDGDALVLSFTGDWHFTAAQSATVADAFRAGGAAGVAHHVVDSDYGHDAFLVDSAA VGPPLADFLAAGTDGAAVTDATGGV Halobacterium sp. NRC-1 NYSGXRC-6172i SGX Pharmaceuticals 2004-03-29 active Selected EC2572 GENBANK NP_343529.1 LQIQFHYMEYSELIKLLEETVRIPFYAILGKLKNNLIYLATSEGEISIYALIGGKNVKLTKSPIAISTRPKSSLDF IPFARDVEKGKEIHAIHIANLKGEEFQIESPRVRISSLTYDDKRIVFTGSSQNETSLYVIENGKLSKLTTIPPFS FVTDVNEKYIIGSGVLKGNPRSQEFFIADFSGNIEILTPKEGSVTNAYYLMGNKVYLISDYETPGESYWIYIYDI ESKKYDRVEIPGFEFKAIEIYYDPEDLLIIAKKDGESRLFDNGKEINTPKGTISGATRIGDEIYFSHSSLVSPHK IYKVSRYGKIEVVVDNRKVDVGEVEYVKVKTDVEVPTWVIKRKIPGNTIIYIHGGPWSEVDNSWNLLIAPLVLAG YNVIAPNYRGSTGYGSKFMFMNIGDAGGGDLRDVVKVRDYAIETGITNKVGIMGYSYGGYMTLLAVGKEPDKWDF GIAGAAVADWVEMYDLSDSLFRGFMEILFNGKNIDLMKERSPITYVRNVKVPLCIIHSQNDTRTPLNPVMRYIQE LQRTGKTYEFHVIPNLGHAIYKVSDAIDILLPALIFLKKLEEQ Sulfolobus solfataricus NYSGXRC-6172j SGX Pharmaceuticals 2004-04-16 active Selected Cloned Expressed Soluble Purified EC2572 ICEDB: T1811 VTLQQKELFQKSPLLLENGETLSPVLVGYETYGTLSASRDNCILLEHALTGTAHAAKHFEDDAPGWWDDYIGPGKT IDTDKYFLVCTNVFGGCSGTTGPSSINPKTGEPFRLQFPGFSIKDIIKVQRELLEQLGVTRIVSVIGGSMGGMQA TEWAIDYADITDSIINIASPLAAGPDAIGYNLIMRMAILNDPDFNGGNYVGQPEGGLATARMVGMMTYRTSELFS KRFERFTVAESSPAAFSKEHFQIESYLQYQGDTFVERFDANSYLYLTKAIDLFDVTAPAKDDLPAFSKIKIPYLL IGITTDQLFRIHDLRRGYELLKEWDVPVTYHEVASEYGHDAFLVEKEVPKFEPLIRSFLSNLPVKSI Listeria monocytogenes NYSGXRC-6173a SGX Pharmaceuticals 2004-05-06 active Selected Cloned Expressed Soluble Purified EC4998 ICEDB: T1802, T734 GENBANK NP_345012.1 MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHY ERFIDINLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIE SLPFLEALRQMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKL AQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMTEWSAMVDKVMNLKKQVKISLVGKYV ELQDAYISVVEALKHSGYVNDAEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDV PMLGVCLGMQLTCIEFARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAAY HNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAF VTAAVENSN Streptococcus pneumoniae NYSGXRC-6173b SGX Pharmaceuticals 2004-03-28 active Selected EC4998 GENBANK NP_519247.1 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYE RFVSAKMRKANNFTTGQIYESVIRKERRGEYLGKTVQVIPHITNEIQAFIERGAKASHDGKADVAIVEIGGTVGD IESLPFLEAARQMSLRLGRNQAAFVHLTLVPFIASAGELKTKPTQHSVQKLREIGVQPTALLCRADRPIPDDERA KISLFANMPQDAVISVWDVDTIYKIPQMLNEQGLDRIICEELRIDAPPADLSMWSRMVHTLENPQHEITIGMVGK YVDLTESYKSLIEALRHAGLHTSTRVNIEYIDSEELESGHTQVLESLDAILVPGGFGKRGTEGKIRAIQYAREKT VPYLGICLGMQLAVIEFARHVAGMQDANSTEFNLETEHPVVALITEWQDRDGRVEKRSADSDLGGTMRLGAQRVP VQTGTKASQIYGAEVNERHRHRYEVNNHYVPQLEKSGMIISARTPSENLPEMMELPGAMHPWFVGVQFHPEFTST PRDGHPLFKAYVEAALAHRQRQAQRAVA Ralstonia solanacearum NYSGXRC-6173c SGX Pharmaceuticals 2004-04-23 active Selected Cloned Expressed Soluble Purified EC4998 ICEDB: T1816 GENBANK NP_349494.1 MKTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLKVSIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHY ERFIDENLSKNSNVTTGKVYWSVINKERRGDYLGGTVQVIPHITNELKERVYRVAKEKDVDVVITEIGGTVGDIE SLPFLEAIRQIKYEVGFGNSCFIHVTLLPYLRKAGEIKTKPTQHSVKELRGIGIQPDIIVCRTEKEISKDVRSKI GLFCNIDGDSVISNLDAENLYEVPLMLHDQGLDSLVCKKLELECQEVDNSEWESMVKNIKSLSGEVTIGLVGKYV ELHDAYISVVESLNHGGFANNVSVNVKWINSEEVTKDNVDSVLSDVDGILVPGGFGDRGIEGKIEAIRWARENKI PFFGICLGMQCAVIEYARNVLGLEGAHSSEIDPQTKYPVIDLMPDQKDIDDKGGTMRLGLYACKLSKDTNAYDAY EEEVIYERHRHRYEFNNEFRKRLTEEGLILAGTSPDDRLVEIVEIKDHPWFVGVQFHPEFKSRPNRPHALFRDFI KVACTVKEK Clostridium acetobutylicum NYSGXRC-6173d SGX Pharmaceuticals 2004-04-15 active Selected Cloned Expressed Soluble Purified EC4998 ICEDB: T1853 MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYE RFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITNEIKEKIMRAAKMTDADVIITEVGGTVGDIES LPFLEALRQMKADMGSDNVMYIHTTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNILVVRTELPVSQNTKNKLA QFCDVNPEAVIESRDVETLYSIPLALQAQNMDQIVCDHLKLDAPAADMTEWRALEEKVLNLKKKTKIALVGKYVE LPDAYISVVEALKHAGFDFDSDIEIDWVDSQELTAENVAERIGSADGILVPGGFGDRGIEGKIEAIRFARENDVP FLGICLGMQMACVEFGRNVVGLEDAGSAETNPDVTNNIIDLMADQENIENLGGTLRLGLYPCKLKKGTKTAAAYG NEDVVQERHRHRYEFNNKYRQLFEENGLVFSGVSPDNRLVEIVEIPEKQFFVACQFHPELISRPNRPQRLIKGFV GAALANKESK Enterococcus faecalis NYSGXRC-6173e SGX Pharmaceuticals 2004-04-29 active Selected Cloned Expressed Soluble Purified EC4998 ICEDB: T1847 GENBANK NP_269881.1 MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYE RFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIES LPFLEALRQMKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLA QFCDVNSEAVIESRDVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVE LPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVP MLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYN NQEVVQRRHRHRYEFNNKFRPEFEAAGFVFSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFV TAAIKNSN Streptococcus pyogenes NYSGXRC-6173f SGX Pharmaceuticals 2004-05-04 active Selected Cloned Expressed Soluble Purified EC4998 ICEDB: T1824 GENBANK NP_244659.1 MTTKYIFVTGGVVSSLGKGITAASLGRLLKNRGMKVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHY ERFIDINLNKNSNVTTGKIYSSVLKKERRGDYLGGTVQVIPHVTNEIKERVFRAGRETNADVVITEIGGTVGDIE SLPFLEAIRQIKSDIGVDNVMYIHCTLIPYLAAAGEMKSKPTQHSVKELRSLGIQPNVIVVRTEKPVPEEMKEKI ALFCDIRKDSVIEARDADTLYEVPLDLQAQNLDEIVCDHLNLSCQEADMTEWKSLVEKVKNLSGLVKIALVGKYV ALPDAYLSVAEALRHAGYAFDADINIKWVDSEDVTAENVAEQLQGVDGILVPGGFGDRGIEGKIEAIRYAREQKI PFLGICLGMQLASIEFARNVLGLEGAHSAEINPDTPHPIIDLLPEQKDVEDMGGTLRLGLYPCKLKNGTLAQSAY NDQVIYERHRHRYEFNNQYREQMEAKGFMFSGTSPDGRLVEIVELGDHPFFIASQFHPEFVSRPTRPQPLFREFI QASLRK Bacillus halodurans NYSGXRC-6173g SGX Pharmaceuticals 2004-03-15 active Selected EC4998 MTKFIFVTGGVVSSIGKGIVAASLGRLLKSRDYSVSILKLDPYINIDPGTMSPFQHGEVFVTQDGAETDLDLGHYE RFTDTSMSRLNSVTTGSIYQAVIMRERRGDYNGGTVQVIPHITNEIKERILSVAKETNPSVVITEIGGTVGDIES LPFLEAIRQLRKQVGRQNVLYMHVTLMPYIASAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPIPRGLKQKLS EFCDVPVECVITSQDARSIYEVPLILEGEGLAEQTLKLLQMEQRQPNLEKWQAMVQGLYSPKHTVEIAIVGKYVS LGDAYLSVVEALRHAAIATQGDLQLRWINSEDLETQAPETYLAGVDGIVVPGGFGTRGVDGKIAAIKYARDRQIP FLGLCLGMQCSVIEWARNVGGLAGANSAEFDSTTKYPVINLLPEQQDVVDLGGTMRLGVYPCHILPNTLASKLYQ AEIIQERHRHRYEFNNDYRQLLLDSGYVISGTSPDGRLVEIVEYPQHPFFISCQFHPEFQSRPNTPHPLFTGFVQ AAIAQSHPTANFQTPVKVS Nostoc sp. NYSGXRC-6175a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC4310 GENBANK NP_207303.1 MVFFHKKIILNFIYSLMVAFLFHLSYGVLLKADGMAKKQTLLVGERLVWDKLTLLGFLEKNHIPQKLYYNLSSQDK ELSAEIQSNVTYYTLRDANNTLIQALIPISQDLQIHIYKKGEDYFLDFIPIVFTRKERTLLLSLQTSPYQDIVKA TNDPLLANQLMNAYKKSVPFKRLVKNDKIAIVYTRDYRVGQAFGQPTIKMAMVSSRLHQYYLFSHSNGRYYDSKA QEVAGFLLETPVKYTRISSPFSYGRFHPVLKVKRPHYGVDYAAKHGSLIHSASDGRVGFIGVKAGYGKVVEIHLN ELRLVYAHMSAFANGLKKGSFVKKGQIIGRVGSTGLSTGPHLHFGVYKNSRPINPLGYIRTAKSKLHGKQREVFL EKAQYSKQKLEELFKTHSFEKNSFYLLEGF Helicobacter pylori NYSGXRC-6175b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC4310 GENBANK NP_461954.1 MVLSAGRLNKNSLGIAVLLCTGLLLAGCSSNSGSGTYSGSVYTVKRGDTLYRISRATGTSVKELARLNGISPPYTI EVGQRIKVRGSAKSSTSTRKTSNKTATKTAAVRPSSSVPKSSWPPVGQRCWVWPANGKVILPYSTAEGGNKGIDI AGARGTPVYAAGAGKVVYVGNQLRGYGNLIMIKHNEDYITAYAHNDTMLVNNGQSVKAGQKIATMGSTDAASVRL HFQIRYRATAIDPLRYLPPQGSKPKC Salmonella typhimurium NYSGXRC-6175c SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC4310 MAIKRFKRLRQSLEALFPERHIYIRSGGEMRGYVFSTNKQLLGAAGVAVGALWMGVCTAAMMVNALAVSSTDQQVI KQKAYYERLNADRQARLNSAVAQLSATNGSLEELAASVEKRHAALALLVSDFKGVPGAAEALQVAKPRLLAASPV QRVQATRMDQERLIDAAESFAKSRAERLRLAMRMAGLDAGNYTGRGVSLGGPLIEAKDPRALAAVLDVDEEFATR IQRAANDMSDMRLLGAAAKKLPFYRPTSNPALSSSYGVRFDPFTRRPAFHSGLDFPGGYHTPIMATAPGVISFTG VRSGYGKTVEIDHGGGFKTRYAHLAAISVRVGQRVAIGSRVGGMGSTGRSTGPHLHYEVWVNGKAQNPNRFLKAG EYVQQAS Caulobacter crescentus NYSGXRC-6175d SGX Pharmaceuticals 2004-02-23 active Selected EC4310 MSKIFLLFNAGFFFLKIIYVFSYPEIKNFSRQDPVFSDLKIKVLKYNKKQHIPLFFYSYKVKKGDTFFKIANKING WQSGIATINLLDSPAVSVGQEILIPSKKGVFVFDSKDYRFNNLLLATRDLAKAEKVKIKRNDRVYEFYFFDFVKN PDFGLFSGTELLFFLNANFIFPLKKFIVSSDFGFRNDPFTGNKSFHTGIDLAAPMNAEVYSSSSGIVIEAGYNDL YGNFVVVGHKNNIKSLYGHLNLYSVKIGDFVKSGEFLGVGQTGRATGPHLHFEILKKNIPINPLKFLK Borrelia burgdorferi NYSGXRC-6176a SGX Pharmaceuticals 2004-06-24 active Selected Cloned Expressed Soluble Purified EC1125 ICEDB: T1884 GENBANK NP_288491.1 MNNKGSGLTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGR FTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVIDGSELTLDRSMSAGLTRYFPTTEL AQIGDETADGIYHPTEFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDS PYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVCY IGHCGGLRKVRPLADYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVT TDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKLPGQANRFYEGAISEH LQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR Escherichia coli NYSGXRC-6176b SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC1125 MTDTRASAHLYPAHDLAVCTDAGSAVERITAIYDRSAQAIRARFHAFARGEALDDDTPACYPYLGITVDPKTLVSD ARPSWGTVAYPGVYGTTLTRPDLFREYYRVQIERLLHYHNSPVVVGVSNRPIPLPFVVEASTIDITPEQARALGG AFPLPDLAQIDDAIANGTYRPADNEPQPLSMFTAERVDLALQRLYHYTATHPKHFQRFVLFTNYQRYVDEFAALG RKLMEEGNDEGYVRFVEPGDTVHELGTPAPDDSHRIKGLPQMPAYHLVREDRLGVTLVNIGVGPSNAKTITDHLA VLRPHCWMMIGHCGGLRRSQQLGDYVLAHAYVRDDHVLDQDLPPWVPVPPIAEIQVALQEAVARITGLSGSDMKS RMRTGTVVSTDDRNWELKYQALYTRFNQSRAIAIDMESATIAANGFRLRVPYGTLLCVSDKPLHGELKLRGMANL FYRQRVSQHLAIGMEAVRLLRENGVETLHSRKLRSFDEPAFR Ralstonia solanacearum NYSGXRC-6177a SGX Pharmaceuticals 2004-04-23 active Selected Cloned Expressed Soluble Purified EC692 ICEDB: T1828 GENBANK NP_389615.1 LNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYKGMDIGTAKITEQEMEGVPHHLIDILDPQDSFS TADYQSLVRNKISEIANRGKLPMIDGGTGLYIQSELYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADP EAAAAIHPNNTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMMQSGLLPEV KRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQLTWFRNKMQVTWFDMTPPVDMELKK KEIFTHIAGKLEL Bacillus subtilis NYSGXRC-6177b SGX Pharmaceuticals 2004-11-28 active Selected Cloned Expressed Soluble EC692 GENBANK NP_355007.2 LTAFAAASPRAAVRTGFDGLAISVATRAMMKNLDQNFDAILITGPTASGKSALALRLARERNGVVINADSMQVYDT LRVLTARPSDHEMEGVPHRLYGHVPAGSAYSTGEWLRDISGLLSDLRGEGRFPVIVGGTGLYFKALTGGLSDMPA IPDDLREGLRARLIEEGAAKLHAELVSRDPSMAQMLQPGDGQRIVRALEVLEATGKSIRDFQRASGPMIIDPERA QKFIVLPERPVLHDRINRRFEAMMDSGAVEEVQALLALNLAPDATAMKAIGVAQIADMLTGRMGAAEVIEKSAAA TRQYAKRQMTWFRNQMGDDWTRIQP Agrobacterium tumefaciens NYSGXRC-6177c SGX Pharmaceuticals 2004-05-04 active Selected Cloned Expressed Soluble Purified EC692 ICEDB: T1826 GENBANK NP_420901.1 VESSDIASRIWLIAGPTASGKSAYALDLAERIDGEIVNADSMQIYAGLRVLTAGPSQEETARAPHHLFQIVDPALG WSVGRWLEAATQALAEIQARGKPAIVVGGTGLYFRALTHGLADVPPVPETQREISSLLYAARGETEFREILKPLD PEAEARIESGDRQRLVRAHAVAITTGKSLTAWQTDTKPALAPGSWKGLVLDPPRAELYARCDARLAVMVEQGALD EVRALETRGLDPALPALKAVGYREFAAHLRGETSLDQALDAARQETRRYAKRQLTWFRNQTPDWERIVP Caulobacter crescentus NYSGXRC-6178a SGX Pharmaceuticals 2004-03-30 active Selected Cloned EC4299 GENBANK NP_646207.1 VYATDKPGALTQPTFAVLNDRGSGNAPGGGVQEVIHRADGTFHAPQGRDVVVPLGVGDSVINANDTLKLQRMGVLP KFHGGTKKKDWLDQLKGNIGKKAGEFGATAKNTAHNIKKGAEEMVEAAGDKIKDGASWLGDKIGDVWDYVQHPGK LVNKVMSGLNINFGGGANATVKIAKGAYSLLKKKLVDKVKSWFEDFGGGGDGSYLFEYPIWQRFGRYTGGLNFNG GRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGKSGAT GNFVRGAHLHFQLMQGSHPGNDTAKDPEKWLKSLKGSGVRSGSGVNKAASAWAGDIRRAAKRMGVNVTSGDVGNI ISLIQHESGGNAGITQSSALRDINVLQGNPAKGLLQYIPQTFRHYAVRGHNNIYSGYDQLLAFFNNRYWRSQFNP RGGWSPSGPRRYANGGLITKHQLAEVGEGDKQEMVIPLTRRKRAIQLTEQVMRIIGMDGKPNNITVNNDTSTVEK LLKQIVMLSDKGNKLTDALIQTVSSQDNNLGSNDAIRGLEKILSKQSGHRANANNYMGGLTN Staphylococcus aureus NYSGXRC-6178b SGX Pharmaceuticals 2004-04-22 active Selected Cloned Expressed Soluble Purified EC4299 ICEDB: T1815 VVKNKFTITITDINGSRHFYLNQIIKKIVFYIIAFIVLFLVFSGFYIKYLDSKLSDISEKREELLKKSKELELSNS QMQKSIEEKTQQYAAIEDKIASFEEALGLEAENNLTISARLDNLQLTNEQQLGILGQIPNGWPIENKGITGNFGW REHPLLKRREFHPGIDLRAEIGTPIYAPASGVVEFSGYSDNGYGYNVILLHNFGFKTVFAHMMRKEVVKAGQFVN KGQLIGYSGNTGLSTGPHLHYEVRFINKTLEPLYFLNLQRKNMNDFFNQERRVPWQSLIKAVSAQHPALAQKQQ Campylobacter jejuni NYSGXRC-6178c SGX Pharmaceuticals 2004-06-08 active Selected Cloned EC4299 GENBANK NP_390480.1 MAKLTATFELHDKISRKLRMIQGNAERLKRAANGPLIFEAEDRTERVMRQIDRSANRLTARARLLEMGLDDRVSNG LHSIRQQAEDLTEGSHEVTVSVNDQATPRFRLIRGGLTDLNSSHAEPTVSVRDHASNQLDEIRRHVTDVDSEHAE PTVSIKDRASAALDAIEAKIDSLKGATITLAVAGGFPAGSIMGSGKSTMSQDAYVSATSNVNKKDVAKMTDQIYF NNKAGSSREEVSLSLRNLSQQTGASKKALAELTESSSKIAQLMNADQAEVDRAFSSMYNNLKLSGKQSGDLIAYV YRNAGDQADDLLDTMNEYSSTFKDLKLTGGQIANAMIKGTKGGARNFDNLADSMREFNIRRTEMSDSQVDAFKTL FGAKETKKMFKGFKDGSISGEESLFRVAKALSKVKDKTKRAAIATELIGTQYEDLKQPILDMAEGIGTSAKTSGE LERSFTKLRDNNPMTPVNDAMRDFESISKDMGTSLLTGLGPAFDKISSFINSKEGQEKLKEIKKDIADLGEEIGD KLNVAIEWSVNHWDDLKTAIKVVIPSLIGLIGYLKILRPLLKGIGTVGSDAAGVIRKLIPKRTPKAGTNTQSERR NRNSNRNASTRGRESKTATGPTSLPRSGSLTYCCCSDGGKNDRIRRRRGKRVLGRRGNPNRMNPSDSSIAVSSER LERRRSGRTVGTNPTRDSRSAIITTRSELYSAGRAAGGTSKFGKVLSPLKSVGKFAKGVPLLGTALAATDLIGMN KDNVGEKIGSAGGGLAGAATGAAIGSVIPGVGTAIGGLVGGIAGTMGGSSLGKAFDGSEVKKKLNSTLFDQKWWS EKWSGIKSNAKTSINGLSDTWSNVKEKVKSTLFNSEWWSEKWSGVKSWAQNKWNSASPVWESVKGKIKSTLFSEK WWSGKWEGVKSWAQSKWDSASSVWQSVKGKLKSTLFSEKWWSGKWESVKSWSKNKWDNAKSIWKSVKSSISETLF SKKWWSEKWQSVKELGSSILGGVKEVGGKVASSAKKTAGKAWGYVKSGVNYLFGSGKEKPKKHATGGYITKPTIS WIGEAGKEFVIPVENNKGRGKMLLSQAASKLGMSVVDDIASASSAGGEPATSPLVRSAAVTASVSPIIDTSSLDE QATSFGQQFTKSFDQGIRDNVVSMEAWKQKNVGQPMNNLISYSPNYGKQVVNGYAKGQNSTSTGTDGFLQTKVKM PFQNTVNKSSSWGSGTIKGFASGQNSSQTGTDQYVSTHINKPFIRSKESSNGWGSGMIGNFVSGMTSKASEVNEA AKELAKKVEKAFREELDIHSPSRVMMSLGRFASIGIVKGLDSVDVKKFAEKQAGSLAAAYSGMGAVSGNVKQWLM AAIMATKTPMSWLPGLMTIAQHESGGNPKAINLWDSNAKAGHPSQGLMQTIPSTFNAHKLPGMNNILNPIHNAAA AIGYIKSRYGSINNVPGIRSMRHGGPYVGYANGGLITKEQIARVGEGNKREWIIPEERGIRGRYLLAQAAKALGM EVTDPSEKGQTELSSGQVTAATTGRNQTTFKAAGGKEVIIQFNGDQHFHNDQDMNSLVAKIKQALVDELEQDINI GTKGVVAFD Bacillus subtilis NYSGXRC-6179a SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC3780 GENBANK NP_012403.1 MSIISSWLLVSIICLTTSIVTKLQAAGVTTHLFYLTRGAPLSLKENYYPWLKAGSFFPDALYSCAPSNKDWSDFAE FTHWPNFLMIAVSYWQQKYGQNDRLRGTHGSLALKSFLIGVFTHQIVDVSWHSLVTDYRMHGLLRVLSETEFDGD IETAHTFLDVMGEFLTLNNVIRDSNNNENWDFLTRSDWKLPREEDLMEIIRNAGLSKEKLSYAELEFCVKRGMAA AISEGYLFRSQRNQLLTNIYSTSPRANDLILNHWLGGQSNLVAMLQRCVPFFETLFHDENTNEAQAEELRLCANL PPVSQKRINARPLVSSLKARKGNSHIVVSPMKSFSDFGTSLTMGKFREDNKDYLAVSAPLEDTVGAIYIVPWDIL TVARKEDFSILQPITAMYGSKVGTYKASDVDYLLVSQPGTCTIDFYFKGVKILTIKDETTEEAHQLQFAVTGNFY DDKIPDLVVSSPSYGANETGIATFIPGSSIISYLTNSDKYQVVDISTFKGVINLDGYPMKIPFQHFGATIQISDT TDKQKLIYITCQSLGTVFVYSSNDLHDLSIPIYYITKNGVIPAKDSDHVEWHIIPSKEHGMFGAAIYSWNFEGMS FVAVSQPMFDTVFIYIEKSGQIEFFLKLVLKIKTKSDSIPDEFGSSLLFNDEEKKLYVSSPGSFDARGSIWKISM DELLKAGNDPKRKTLLINNLRHLMLINPDKSSKGVSNFGNSMILGPQNHLIVGIPQYGYGNFDHMQLTGRILVL Saccharomyces cerevisiae NYSGXRC-6179b SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble EC3780 GENBANK NP_708313.1 MAELTALYTLTAQMKREGICRLLVLSGEEGWCFDHALKLRDALPGDWLWISPQLDAENHCSPSALQTLLGREFRHA VFDARHGFDAAAFAALSGTLKAGSWLVLLLPVWEEWENQPDADSLRWSDCPDPIATPHFVQHLKRVLTADNDAIL WRQNQPFSLAHFTPRTDWHPATGAPQPEQQQLLQQLLTMPPGVAAVTAARGRGKSALAGQLISRIAGSAIVTAPA KAATDVLAQFAGEKFRFIAPDALLASDEQADWLVVDEAAAIPAPLLHQLVSRFPRTLLTTTVQGYEGTGRGFLLK FCARFPHLHRFELQQPIRWAQGCPLEKMVSEALVFNDENFTHTPQGNIVISAFEQTLWRSEPETPLKVYQLLSGA HYRTSPLDLRRMMDAPGQHFLQAAGENEIAGALWLVDEGGLSQELSQAVWAGFRRPRGNLVAQSLAAHGSNPLAA TLRGRRVSRIAVHPARQREGTGRQLIAGALQYTHDLDYLSVSFGYTGELWRFWQRCGFVLVRMGNHREASSGCYT AMALLPMSDAGKQLAEREHYRLRRDAQALAQWNGEMLPVDPLNDAILSDDDWLELAGFAFAHRPLLTSLGCLLRL LQTSELALPALRGRLQKNASDAQLCTTLKLSGRKMLLVRQREEAAQALFALNEVRTERLRDRITQWQFFH Shigella flexneri NYSGXRC-6179c SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC3780 MWYTYNEDFGVVQLLFLHSNDTLTARTHITKGQIDIELTMRTTKKSSKKGIPLNLMVVGDVGLGRTAFINTLCEKP LIRHNNNFDPAEASSVSPVEIVPYQTDIILEDGTKINLTVLDTPHFGEAIDNENNFDIILQYIESQYDNVLEEES RIKRNARFCDDRVHALIYFISPTGHGLRELDIELMRRLAPRVNIIPAIAKADSLTAQELQTTKEMINADIEYYKI PVYDFPYDIEEDEEAIINLSQQLRATIPFAIVSSDRLIEMNGQTVRGRAYPWGVVEVDNPRHSDFLALRSALFAT HIEDLHNITSNQLYETYRTEK Schizosaccharomyces pombe NYSGXRC-6180a SGX Pharmaceuticals 2004-05-12 active Selected Cloned Expressed Soluble Purified EC3469 GENBANK NP_009880.2 MSIPADIASLISDKYKSAFDNGNLKFIQTETTKTKDPKTSMPYLISHMPSLIEKPERGQTPEGEDPLGKPEEELTV IPEFGGADNKAYKLLLNKFPVIPGHTLLVTNEYQHQTDALTPTDLLTAYKLLCALDNEESDKRHMVFYNSGPASG SSLDHKHLQILQMPEKFVTFQDRLCNGKEHFLPTFNTEPLQDAKVSFAHFVLPMPESEETVDEDLLAMCYISILQ RALTFFQDWLNENPELKKSYNLMLTKEWICVVPRSKAFSDEMKIGFNSTGYCGMILTKNDEVFSKITEKPELIND ILLECGFPNTSGQKPNEYNY Saccharomyces cerevisiae NYSGXRC-6180b SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC3469 MWWKFSLYLSHYRYRFPSGKIFTMKILWAPWRRAYVENVDKIEGCFLCHALSQPPEKWKEVLLVYKGKNAFIILNK YPYNTGHLMIVPVKHIGNYEEVDEETALEMHKLLQVSLKALKKEYKPHGFNVGYNFGRPAGAGLEEHIHLHVVPR WNGDTNFMPVLAQTKVISEDLYSTYDRVKKAIEEVLNESS Aquifex aeolicus NYSGXRC-6181a SGX Pharmaceuticals 2004-07-13 active Selected Cloned Expressed Soluble Purified EC1266 ICEDB: T1833 GENBANK NP_336651.1 VQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKKLLEEAGEVWLAAEHESNDALAEEISQLLYWTQ VLMISRGLSLDDVYRKL Mycobacterium tuberculosis NYSGXRC-6181b SGX Pharmaceuticals 2004-04-23 active Selected Cloned Expressed Soluble Purified EC1266 GENBANK NP_353077.2 LQEHPMSAFSLSDLERIVAKRAAASPDESWTAKLVAAGQERAAKKLGEEAVEAVIAAIAQDRDGLKNEAADLLYHL LVVLKIADIPLSDVFAELERRTGQTGLAEKAARPTP Agrobacterium tumefaciens NYSGXRC-6181c SGX Pharmaceuticals 2004-05-03 active Selected Cloned Expressed Soluble EC1266 MDKNEILSKLYNVIEDRKNNPIEGSYTNYLFEKGIDKILKKVGEETTEVIIASKDDNKEDLINEICDVIYHTLVLL NYKNIKLEDIEKELQKRNEKILNKKQERRPIENI Clostridium acetobutylicum NYSGXRC-6181d SGX Pharmaceuticals 2004-07-13 active Selected Cloned Expressed Soluble Purified EC1266 ICEDB: T1850 GENBANK NP_342120.1 VHDMSNEIVDELYKIILDRIEKRPTGSYTAEIVNKGKPYVARKVGEESVETIVASLAENKERFISEVADLIYHLLV LMALEGVTPEDIYRELERRRK Sulfolobus solfataricus NYSGXRC-6182a SGX Pharmaceuticals 2005-04-25 active Selected Cloned Expressed Soluble Purified EC3741 GENBANK NP_371645.1 MKKVNRNILNAVLVGAGFLSSLLMINKNKVITKKQTIPAFFKGNAPYIFAHRGGMALRPEQTQLAFDYAKQLGVDG FETDVRLTKDQQLIVFHDATVDRTTNGSGKVSAHTLAELKKLDAAYHFKDINGLTPYRGHAHTTILTFDELLKQY PDMYINVDLKDAPESYEGSIAPQIMFDTIAENQAFDRVLVTSFYKEQIVRFNKIAQGSVAIGASQQEVTEAFLKY HLLGGRYYQPLAQTFQMPTHFKGIDLTSSRFIKWLNDMNIIPGYYGVNSIDLMNDLYQKGAHTIVTDRPDLAQQF KQTIPNK Staphylococcus aureus NYSGXRC-6182b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC3741 GENBANK NP_214831.1 VEFLRHGGRIAMAHRGFTSFRLPMNSMGAFQEAAKLGFRYIETDVRATRDGVAVILHDRRLAPGVGLSGAVDRLDW RDVRKAQLGAGQSIPTLEDLLTALPDMRVNIDIKAASAIEPTVNVIERCNAHNRVLIGSFSERRRRRALRLLTKR VASSAGTGALLAWLTARPLGSRAYAWRMMRDIDCVQLPSRLGGVPVITPARVRGFHAAGRQVHAWTVDEPDVMHT LLDMDVDGIITDRADLLRDVLIARGEWDGA Mycobacterium tuberculosis NYSGXRC-6183a SGX Pharmaceuticals 2004-03-15 active Selected EC1922 MRVLVLGSGVIGTASAYYLARAGFEVVVVDRQDGPALETSFANAGQVSPGYASPWAAPGIPLKAMKWLLEKHAPLA IKLTSDPSQYAWMLQMLRNCTAERYAVNKERMVRLSEYSRDCLDELRAETGIAYEGRTLGTTQLFRTQAQLDAAG KDIAVLERSGVPYEVLDRDGIARVEPALAKVADKLVGALRLPNDQTGDCQLFTTRLAEMAKGLGVEFRFGQNIER LDFAGDRINGVLVNGELLTADHYVLALGSYSPQLLKPLGIKAPVYPLKGYSLTVPITNPEMAPTSTILDETYKVA ITRFDQRIRVGGMAEIAGFDLSLNPRRRETLEMITTDLYPEGGDISQATFWTGLRPATPDGTPIVGATRYRNLFL NTGHGTLGWTMACGSGRYLADLMAKKRPQISTEGLDISRYSNSPENAKNAHPAPAH Pseudomonas aeruginosa NYSGXRC-6183b SGX Pharmaceuticals 2004-05-03 active Selected Cloned Expressed Soluble EC1922 GENBANK NP_357312.1 MNVTILGAGVVGVTSAWYLAKAGHKVTVIDRQPAAALETSFANAGEVSPGYSSPWAAPGIPMKAMKWLFMKHAPLI IRPTADPAAWRWMSQMLRNCTSARYAINKSRMVRVAEYSRDCLMALREETGIDYDQRMQGTLEVFRTQKQFDAIG KDVDVLTAGGVPFEILDRDGCAAIEPGLAPAKEKIVGGLRLPGDETGDCFMFTTELARMAEEAGVTFLYDTGIMR PIVEGGRIKAVETTRGLIEADIFVAALGSYSPQFVRQLGLTLPVYPVKGYSITVPIVKEERAPVSTVMDETFKVA ITRLGSRIRAGGMAEIAGFSKDLPAARQETLAHSVEDLFGGAGDQSQAKFWCGLRPMTPDGTPVIGATRYSNLYL NTGHGTLGWTMSCGSARVLADLISGNKPEIDTHDLAISRYAA Agrobacterium tumefaciens NYSGXRC-6183c SGX Pharmaceuticals 2004-05-05 active Selected Cloned Expressed Soluble EC1922 GENBANK NP_273234.1 MKVLVLGAGVAGVSSAWYLAEAGHEVTVIDRAEGVAMETSFANAGQLSYGYTTPWAAPGIPTKALKWLFKSHPPLL FRPDGSLYQIEWLWQMLQNCTAAHYQTNKERMVRISEYSREMFRRFEAQTGMNFEGRKKGTLQIFRQTKEVEAAK QDIAVLERYGVPYRRLKPEECAEFEPALARVTAKIAGGLHLPADATGDCRLFTENLYKLCQEKGVRFHFNQNISR IDHNGLRIKTVETETGRFEADAVVCALGCFSRTVLAQLDLNLPIYPVKGYSLTLPVTNSDGAPVSTVLDESYKVA ITRFDNRIRVGGMAELSGYEIKLPEKRRETLALVVNDLFPEGGDLSQASFWSGLRPMTPDSTPLIGRTRFDNLFL NTGHGTLGWTMSLGSAKLTADIVSGKDTEIRSDDLSLSRYQA Neisseria meningitidis NYSGXRC-6183d SGX Pharmaceuticals 2004-03-09 active Selected EC1922 MRVLILGSGVIGTTSAWYLSKAGCEVVVVDRQSGAGLETSYANGGQLSFGYTSPWAAPGVPLKAVRWLFERHAPLS IRPTTDWNQYVWLARMLRHCSAERYAVNKSRMLRLSEYSREALEALSAETGITFEGRHLGTIQLFRTQQQLDVVV RDIELLTQYGIPYEVLSPSQISKFEPGLADGSVRFPGALRLPHDQTGDCCLFTQRLAALAAKRGVEFRYGCTVQR LEVDGPRVTGAWINGALERADCCVVALGSYSPLLLAPLGLRLPVYPLKGFSLTLPMIDASRAPVSTVLDESYKVA VTRFDERIRVAGMAEVSGYDVSLNPRRRATLEMVVQDVYPGCGDLGRGEFWTGLRPATPDGTPVIGATPYQGLFL NTGHGTLGWTMSSGSGRYLADLICCRPCEISSEGLDMFRYLVSTIPCPQECAPCVPPTP Xylella fastidiosa NYSGXRC-6183e SGX Pharmaceuticals 2004-03-28 active Selected Cloned EC1922 GENBANK NP_460759.1 MRVVILGSGVVGVTSAWYLSQAGHDVTVIDRESGPAQETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLA VRLDGTPFQLKWMWQMLRNCDTRHYMENKGRMVRLAEYSRDCLKTLRAATGIEYEGRQGGTLQLFRTAQQYENAT RDIAVLEDAGVPYQLLEASRLAEVEPALAEVAHKLTGGLRLPNDETGDCQLFTQRLARMAEQAGVTFRFNTPVEK LLYENDQIYGVKCADEIIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIVEPDGAPVSTILDETYKIAI TRFDKRIRVGGMAEIVGFNTDLLQPRRETLEMVVRDLFPRGGHIEQATFWTGLRPMTPDGTPVVGRTRYKNLWLN TGHGTLGWTMACGSGQLLSDILLGRTPAIPYDDLSVARYRSDFTPTRPQRLHSAHN Salmonella typhi NYSGXRC-6183f SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC1922 GENBANK NP_836877.1 VAMRVVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAP LAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKALRAETNIQYEGRQGGTLQLFRTEQQYEN ATRDIAVLEDAGVPYQLLESSRLAEVDPALAEVAHKLTGGLQLPNDETGDCQLFTQNLARMAEQAGVKFRFNTPV DQLLCDGEQIYGVKFGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIAQEDGAPVSTILDETYKI AITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHVEQATFWTGLRPMTPDGTPVVGSTRFKNLW LNTGHGTLGWTMACGSGQLLSDLLSGRTPAIPYEDLSVARYSRGFTPSRPGHLHGAHS Shigella flexneri NYSGXRC-6184a SGX Pharmaceuticals 2004-03-15 active Selected EC2617 MFSRWSKPLVLAAVTRASLAADLAALGLAAGDAVMVHAAVSKVGRLLDGPDTIIAALSDAGRPAGTILAYADWEAR YEDLVDEDGRVPQEWREHIPPFDPRRSRAIRDNGVLPEFLRTTPGALRSGNPGASMVGLGARAEWFTADHPLDYG YGEGSPLARLVEAGGKVLMLGAPLDTLTLLHHAEHLADIPGKRIRRIEVPLATPTGTQWRMIEEFDTGDPIVEGL AEDYFAEIVTAFLAGGRGRQGLIGTAPSVLVDAAAITAFGVAWLESRFGSPSS Pseudomonas aeruginosa NYSGXRC-6184b SGX Pharmaceuticals 2004-12-01 active Selected Cloned Expressed Soluble Purified EC2617 ICEDB: T2212 VRSRHPPFPPSRNDNHSVHLPEFTMSNAVHETDSKNTVASKPPLDPHLKALENEAIHIFREVAAEFDNPVMLYSIG KDSSVLLHLARKAFFPGRIPFPLLHVNTGWKFKEMIEFRDNIVKEYDLDLISYTNPRGALENVTPFSHGSALYTD IMKTEALRQALDAGQFDAAFGGARRDEEASRAKERIYSFRTPDHKWDPRNQRPELWNIYNGMVRKGESVRAFPLS NWTEVDIWRYIEAENIPLVPLYYAAERPYIERDGMMILAEDERLELLPGEEIKHGSIRFRTLGCFPLTGAIRSEA ATLQDVIAELEIATVSERQGRAIDRDQSGSMEKKKREGYF Agrobacterium tumefaciens NYSGXRC-6184c SGX Pharmaceuticals 2004-02-23 active Selected EC2617 VAYAWPMTEDTAIAHADAPRTRASLAADLRSLGVQAGDVLLVHSSLSRLGWVAGGAVAVIQALQDVLTPQGTLVMP THSSDLTDPAGWLSPPVPEAWWEVIRAELPAFDPALTPTRGMGRIPELFRTWPGVRRSDHPHSSFAAWGRHAEFV TAGHALAFSLGEGSPLARIYDLNGRVLLLGTERNTNLHLAEVRAGVRPTVAVSGPVMVDGERQWLTFDEPDYDAE AFAPVKAAFEAAGGVVRGTVGSAQARLMSQRELVDFAVNVWRVVRVPPHSSPS Deinococcus radiodurans NYSGXRC-6184d SGX Pharmaceuticals 2005-01-13 active Selected Cloned Expressed Soluble EC2617 MGEKMAIWRTKKPATKQKIVSDLQELGIKKGDTIIFHASMSKAHWICGGPVTVILALQELVGELGNIVMPAQTGQL SDPAKWENPPVPESWWKIIRRETPPFDPLVTPTRGMGVIAETFRTMPDVERSFHPYHSFCAWGKDKKQILANQPL AKSMGDESPLGKMYQLDAKIILFGVDNNNNTSLHLAEERSNAFPLIENQAAFLKNGEIIWEKYQEIDYNSEVFIA LGRAYEKEHDFHPTTIIGAPTKIYDMRDLVDFGTKYFQTKNH Listeria monocytogenes NYSGXRC-6185a SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified EC696 ICEDB: T2200 GENBANK NP_217243.1 VRPLAIIGPTGAGKSQLALDVAARLGARVSVEIVNADAMQLYRGMDIGTAKLPVSERRGIPHHQLDVLDVTETATV ARYQRAAAADIEAIAARGAVPVVVGGSMLYVQSLLDDWSFPATDPSVRARWERRLAEVGVDRLHAELARRDPAAA AAILPTDARRTVRALEVVELTGQPFAASAPRIGAPRWDTVIVGLDCQTTILDERLARRTDLMFDQGLVEEVRTLL RNGLREGVTASRALGYAQVIAALDAGAGADMMRAAREQTYLGTRRYVRRQRSWFRRDHRVHWLDAGVASSPDRAR LVDDAVRLWRHVT Mycobacterium tuberculosis NYSGXRC-6185b SGX Pharmaceuticals 2004-04-28 active Selected Cloned Expressed Soluble Purified EC696 ICEDB: T1818 LEKVLVIVGPTAVGKTALSIALAKKFNGEIISGDSMQVYRSLDIGTAKVTETEKEGIPHYLIDCREVSETYSAADF QKEGRQKIKEITEKGKLPIIVGGTGLYIQSLLYDFQLGSREIDDSPEIRETYNLFAEEKGNQALWLLLQQKDPLA ANSIHFNNRKKVIRALEVFDKTGYSILTPKEKPARLYDYYLLGLETDRALLYERINQRVDQMMTEGLLEEAKQMF QQPHAQAAQGIGYKEFFPYFSGEQSLEMAVETVKQQSRRYAKRQLTWFRNRMAAHWWNLVQQPTDLPKLEKEVAE WLQQKESE Enterococcus faecalis NYSGXRC-6185c SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC696 VEEFEGEAIVEAENVVSIMLRREAAERADEILHFSYWSGEIKELDAPGYLDRWQKKCYHATCSLDEGEILLVVGPP GSGKTTFIAEAARKLSEEERVWVTSNTNIAVDNVLEKLERALRIGHPSKITAGVRRHSVEYNLLSGIRFSDYREY ASKVAEAYREIARIQNDMIRKGKIVVGSTILKGMMSALKNYDFDTVIIDEASNTCISTALLALEKAEKAVVVGDP YQLPPVYEVGGHKAAKFSAYNFLINIYGKNLWLRRHYRSNAKIAEFAARHVYGFLEIDEKCRRIKIEPCKTTIPE VGDPEKPLVFIDCNGVERREGRSKVNEEEAEVVAMIAEELAECVGEENVGVITPYVKQAELIRGILSEFGVMVEV STVHSYQGREKDVVIYSITATGNPYFASEKRLFNVALTRARKKFIAVGNSKALEGKNLLLTRFMVAAIKEGGFVR LR Archaeoglobus fulgidus NYSGXRC-6186a SGX Pharmaceuticals 2004-02-23 active Selected Cloned EC2372 MQAVIYGKQVIMHLLNSHQEKLQEIYLSKEIDKKLFFALKKACPNIIKVDNKKAQSLAKGGNHQGVLAKVELPLAV SLKEVKKAQKLLVLCGITDVGNIGGIFRSAYCLGMGGVILDFAKELAYEGIVRSSLGLMYDLPFSVMPNTLDLIN ELKTSGFLCLGASMQGSSQIENLSLKKCALFLGSEHEGLSKKILAKMDTILSVKMRRDFDSLNVSVAAGILMDKI N Helicobacter pylori NYSGXRC-6186b SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC2372 MIVYGKQIFFYILEYHKDCINELYLAKECDKITFSKIAKSGFKIKKLDFKTAQAYAKGGNHQGFLLDIKESSFANL NEIKKNDFIVMLYGISDVGNIGAITRTAYALGVGALIFIGEKLAMEGVIRTSSGAALDLPIVISNDALSVINELK QVGFYFYASDGSGKEIHSVKISNGKKVLVLGSEGFGLSSKIVKKCDECVGIAMKNNFDSLNVSAAFAILCDRMLN A Campylobacter jejuni NYSGXRC-6186c SGX Pharmaceuticals 2004-04-21 active Selected Cloned Expressed Soluble EC2372 MEKKFVIWGRNPIIEALRAGRNLEKIYVAHDSHPPKELLELAKKRGVKVQRISRKKVEELAGTKKTQGVVALLSPV NYVSPHELFKECIEKKSFFIVIDHITDPQNVGNLLRTCEVLGGVGALISKDRTSPINETVVKASSGAVFHLKISK VSSLSRELKNFQKMGGWVFAVEKGGKDIREVDIPLPVALVLGSEDKGVSKSVLDISDQIVTIPMKGKVTSLNVGS AGAIAMWETAKKIL Aquifex aeolicus NYSGXRC-6187a SGX Pharmaceuticals 2004-03-29 active Selected Cloned Expressed EC818 GENBANK AAB49995.1 VALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQVCPAPPPRELDMLLTAGERI SNALVAMAIESLGAHARSFTGSQAGVITTGTHGNAKIIDVTPGRLQTALEEGRVVLVAGFQGVSQDTKDVTTLGR GGSDTTAVAMAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIP VHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVARRRRQHRHGAAERL QGRGRQDRHHLHLLPQTSGPPPWKNWTRSETRSASTQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNI ELISTSEDQRSRCCAATPNWTRPWSRCMKRSGSAATRRPRCTRGRDGRWACQ Mycobacterium tuberculosis NYSGXRC-6187b SGX Pharmaceuticals 2004-02-23 active Selected EC818 MGNTTDELLDDITFDADEPDRAEIVSMGERTSVRMLKAALAARGVDATFLEPGTTDWPIVTNERGEVDADATAAGV DRLAGRLGDTVPVITGFLAEDPQGNVTTLGRGGSDTTAVMLGRYLDADEVVIVTDVEGIMTGDPQVVEGARNVGR ITVDELRNLSFRGAEVIAPSALSFKDDALDVRVIHYQHGDLLSGGTRIEGTFESMIDMRDSPLACLTVAGRAIRN RPGITSALSTALSDSDINVDAVASGMDSMTFYVDESVAERAENILHQEVIAVSELSSVTVTDDIAAIRVLGGELP NRPGVLCRIIDPLADRNINVIDIISSATSVAVFVSWADREPALDVVQNGFGS Halobacterium sp. NRC-1 NYSGXRC-6187c SGX Pharmaceuticals 2004-03-27 active Selected Cloned Expressed EC818 GENBANK NP_487684.1 MALIVQKFGGSSVGSVERIQAVAQRVYKTVKAGNSLVVVVSAMGKTTDGLVKLANEISRNPNRREMDMLLSTGEQV TIALLSMALQELGQPAISMTGAQVGIVTEAEHTRARILHIETERVEGHIKEGKVVVVAGFQGISSNGSLEITTLG RGGSDTSAVALAAALQADFCEIYTDVPGILTTDPRIVPEAQLMGEITCNEMLELASLGAKVLHPRAVEIARNYGM PLVVKSSWTDDPGTWVTTPKPQGRSLINLELARPVDDVELDTDQAKVALLRVPDKPGVAAKLFGEISRQKVDVDL IIQSIHEGNSNDIAFTVTTPILKRAEAVAAAIAPSLRSPSHPKSDEAEVMVEQNIAKVSIAGAGMIGRPGVAAQM FATLAEAGVNIQMISTSEVKVSCVIDAQDGDRAIIALRKAFEIETPLHSQLPTPSSLSTHNSPPVRGVALDLNQA RLAIRQVPDRPGMAAQLFGILSQHNISVDMIIQSQRCRIVDGVPRRDIAFTVPRMDGETAQKLLCQVAPELGWGD VVLDSAIAKVSIVGAGMVGQPGVAAKMFEALAKHQINIQMIATSEIKISCVVSQEQGVQALQVIHTAFELAGTEK FVVPA Nostoc sp. NYSGXRC-6187d SGX Pharmaceuticals 2004-03-29 active Selected EC818 GENBANK NP_519292.1 MALIVHKYGGTSMGSVERIKNVAKRVAKWHRAGHQIVVVPSAMSGETNRLLGMAKEISAQPDPRELDMIASTGEQV SVGLLAIALHAEGIDAISYTGWQVPVQTDSAYTKARIQSIDDERVRADLEAGRVVVITGFQGIDGEGHITTLGRG GSDTSAVAVAAALEAEECLIYTDVDGVYTTDPRVVDDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKT RVLSSLTDPLMPLEVEMHSGTLITFEEDSNMEAAAISGIAFARDEAKITVIGVPDKPGIAYQILGPVADANIDVD MIIQNQSVDGKTDFTFTVPRGDYQRALGILNDSVKGHIGAANVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSE EGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA Ralstonia solanacearum NYSGXRC-6187e SGX Pharmaceuticals 2004-05-04 active Selected Cloned Expressed Soluble Purified EC818 ICEDB: T1823 PFAM PF00696 VNVVKFGGSSLASAPQLQKVLQIVKEEPRRTFVVVSAPGKRTPQDIKVTDLLIQYYQRYLNNEEIESTISAIIRRY EDLFDELHLDKAVLADIAISIRQLATLPKENNAFLFDYFLASGEDNNAKVVASFFKQNGLDARYISPKELGLLVT PEPGNARILPKALEKISVYRETQQILVIPGFFGYTEAGEICTFSRGGSDITGSIVAAGVQADLYENFTDVDGIYV AHPGIIEQPQTIQELTYREMRELAYAGFAVLHDEALMPAYRANIPVVIKNTNNPHHPGTLITTSRKVKHAPVVGI ASDQGFASIYISKYLMNRELGFGRRLLEVLEKLALSYEHMPSGIDDITIVLREDQLTTEIENRLMAQLQEVLAPD ELRITHHLSMIMIVGEGMRQRIGVTAESTMALAKEKINLEMINQGSSEVSIMFGIKKEQEEKAIKALYRTFFHD Enterococcus faecalis NYSGXRC-6187f SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble EC818 GENBANK NP_393581.1 MMILKIGGSVITDKSAYRTARTYAIRSIVKVLSGIEDLVCVVHGGGSFGHIKAMEFGLPGPKNPRSSIGYSIVHRD MENLDLMVIDAMIEMGMRPISVPISALRYDGRFDYTPLIRYIDAGFVPVSYGDVYIKDEHSYGIYSGDDIMADMA ELLKPDVAVFLTDVDGIYSKDPKRNPDAVLLRDIDTNITFDRVQNDVTGGIGKKFESMVKMKSSVKNGVYLINGN HPERIGDIGKESFIGTVIR Thermoplasma acidophilum NYSGXRC-6188a SGX Pharmaceuticals 2004-04-29 active Selected Cloned Expressed Soluble Purified EC1552 ICEDB: T1846, T697 GENBANK EDN63419.1 MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYER YLGITLSRDHNITTGKIYSQLISRERRGDYLGKTVQIVPHLTNAIQDWIQRVSKIPVDDTGLEPDVCIIELGGTV GDIESAPFVEALRQFQFEVGRENFALIHVSLVPVIHGEQKTKPTQAAIKDLRLLGLIPDMIACRCSEELNRSTID KIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQHMIDYLHSRLKLGEVPLTLEDKERGSQLLTNWENMTKNLDDSD DVVKIALVGKYTNLKDSYLSVTKSLEHASMKCRRQLEILWVEASNLEPETQEVDKNKFHDSWNKLSSADGILVPG GFGTRGIEGMILAAKWARESGVPFLGVCLGLQVAAIEFARNVIGRPNSSSTEFLDETLLAPEDPSSHIHAEIDKE HMGGTMRLGLRPTIFQPNSEWSNIRKLYGEVNEVHERHRHRYEINPKIVNDMESRGFIFVGKDETGQRCEIFELK GHPYYVGTQYHPEYTSKVLEPSRPFWGLVAQLRHTCEVIKDINLSEGNENE Saccharomyces cerevisiae NYSGXRC-6188b SGX Pharmaceuticals 2004-06-29 active Selected Cloned Expressed Soluble Purified EC1552 ICEDB: T1886 GENBANK NP_069090.1 MKYIVVTGGVMSGLGKGITAASIGRLFVDMGYRVIPIKIDPYINIDAGTMNPFQHGEVYVLKDGTEVDLDLGHYER FIGEEVTGDHNITTGKIYKRVIEKERKGDYLGQTVQIIPHVTDEIKSWIRRVAKESNAEICLVEIGGTVGDIEGM PFLEAIRQMHNEEKEEDFALVHVTLVPLDAGGEQKTKPTQHSVKELRELGLHPDVIVGRCSERLKPATKKKIALF CDVPEEAVISNEDAEDIYEVPLIFKREKLDEYLMRKLNLRAKESRKEWEEMVKRMKTLYEEASIAIVGKYVDVRD AYLSIKEALKHGGIEAGCKVNIVWVDSEDLENVDDFTLDVDGILVPGGFGARGAEGKIRAIEYARENGVPFLGIC FGFQLAVIEFARNVVGFSEANSTELDENTPHPVIDLLPEQKGIDEMGGTMRLGDIEVTIKPGTIAHKLYGSEKVV ERHRHRYEVNPEYIEKIESKGLVFSAYSDGGRRMEIAELPDHPFFFATQFHPEFKSRPYRPSPPFVGFVRAALKY RREEEI Archaeoglobus fulgidus NYSGXRC-6189a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3172 MSSLPPAIFLMGPTAAGKTDLAMALADALPCELISVDSALIYRGMDIGTAKPSRELLARYPHRLIDIRDPAESYSA AEFRADALAAMAKATARGRIPLLVGGTMLYYKALLEGLADMPGADPEVRAAIEAEAQAEGWEALHRQLAEVDPES AARIHPNDPQRLMRALEVYRLGGVSMSDLRRRQSAEKADFDASGRNQLPYTVAQLAIAPEQRQVLHARIAQRFRQ MLEQGFIAEVEALHARSDLHAGLPSIRAVGYRQVWDYLDGKLSYAEMTERGIIATRQLAKRQFTWLRSWSHLHWM DSLAGDNLPRALKYLKTVSILA Pseudomonas aeruginosa NYSGXRC-6189b SGX Pharmaceuticals 2004-06-17 active Selected Cloned Expressed Soluble Purified EC3172 ICEDB: T1844 GENBANK NP_904649.1 LETQDHTLYVLLGPTGVGKTDLSLDIAERLGSPIISADSRQIFRELPIGTAAPTPEQRAKVPHLFVGTHSVRDYYS AGMYEVEVLEALKELFRKYRGVLLTGGSMMYIDAVCRGIDDIPDPFPEVREELYARYAAEGLDGILAQLRLLDPD YYAKVDRRNYKRVIHGLEICLSTGRPFSSFHRHEAKERPFRIVKIGLYREREELCKRIDARVLEMMEQGLEEEAR AVYPLRHLNALNTVGYKEMFEYFDGSIDRAEAVRRIQRNSRVYARKQMTWFRRDSTIRWFHPEADKGTVLTLVT Porphyromonas gingivalis NYSGXRC-6189c SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC3172 MTAAPHTAPRAVCLLGPTASGKTAAALALAERWPVEIISMDSALVYRDMDIGTAKPSRAEQAIAPHHLIDIIDPLD AYSAAQFATDAQALIEAIRARGRLPLIVGGTMLYYKALTQGLSDLPGADPAIRAEIDAEAARDGWPALHAKLAQV DPVTAARLHATDAQRIQRALELYRLTGQPMSALLAREAGAAAFHRHEAAAAYLSIALEPADRAVLHARIAQRFDA MLAGGLLDEVEALRRRGDLSPVLPSIRCVGYRQAWAYLDGEIDMATLREQGIAATRQLCKRQITWLRSTPERRVV DCLAPDYVDQVARLVRNALETP Ralstonia solanacearum NYSGXRC-6190a SGX Pharmaceuticals 2004-01-19 active Selected EC1604 VALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQVCPAPPPRELDMLLTAGERI SNALVAMAIESLGAHARSFTGSQAGVITTGTHGNAKIIDVTPGRLQTALEEGRVVLVAGFQGVSQDTKDVTTLGR GGSDTTAVAMAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIP VHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVARRRRQHRHGAAERL QGRGRQDRHHLHLLPQTSGPPPWKNWTRSETRSASTQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNI ELISTSEDQRSRCCAATPNWTRPWSRCMKRSGSAATRRPRCTRGRDGRWACQ Mycobacterium tuberculosis NYSGXRC-6190b SGX Pharmaceuticals 2004-07-06 active Selected Cloned Expressed EC1604 GENBANK NP_230198.1 VKKPLIVQKFGGTSVGSIERMQTVAEHIIKAKNDGNQVVVVVSAMAGETNRLVGLAQQVDSVPNARELDVLLSAGE QVSMALVAMTLHKMGYAARSLTGAQANIVTDNQHNDATIKHIDTRTITELLEQDFIVIVAGFQGINENGDITTLG RGGSDTSAVALAGALNADECQIFTDVDGIYTCDPRIVPSARKLDVIDFPSMEEMARKGAKVLHLPCVQYAWKHAV PLRVLSTFEVNQGSLIKGSAATHAVCGIALQRDMALIRVESESFPSIIKQCQMLGIEVCTTIDEPTHSAFVIKRD AYAKLQLVGADKIRGSEPVSLITKVGIQAGALVAHARQTLAQHGIDVRYVSASEQSSMLMLDPANVDRAANILHE TYVTSEIPQEFGLKQTFLG Vibrio cholerae NYSGXRC-6191a SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3692 MLLFEQPVDLEKNNEDDTNIKPFAISRHFLLKLLLCGIILIELLLYSKCPKPIDNGPRTIANRSNTYFNGTHDFKT LTILISIDGFHPRLIDAKYTPFLYNLHNLRSPYDMNITTAPYMIPSFPTQTFPNHWSMVTGKYPIEHGIVSNIFW DNFTSSEFRPNNLDARIWSNTADPIWQLLQTESQGEYKVATHMWPGSEVVYEDHGDVPRERMPFYFGKFNQWEKL QDKLAQIFRYIDMPQLKDRPELVISYIPNVDSYGHSFGYDLRDKRLQKLIGEVDGFFLDLIEGLQKRNLLKISNV MIVSDHGMSNVNANDGEHVVVWERVFPADAMSAFISHLYNEGPMMMVCLKNPRDKQWICDLIEAQLEKAYGDEIS RKFHVILKEDFDPSWKYFQYDNRKHRYDDRVGDIWILADEYYAIVKEMGDVPIGIMGTHGYNFNNCSDMASIFIG MGPMFNNEVVPPFENIEVYNMLIKASALLGEEKTKKEKSLLQ Saccharomyces cerevisiae NYSGXRC-6191b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3692 VRDLKTLLIVIDGVSYSVFNQFRYNLDTMNNLIENGSFGKLESVFPTITPVALASLFTGYLPLNHGITSTKIFIKG NSLSKPLSAHSSTPLKVDPIWYLLAKKGYKVVVASAPQALPDKWKLKNLTLFDPYKSKIKECSDGALLNIGNTTI NEVNFDIESNNNEYTIKITDIENNTLSLKLRQNEWTSPLEVIMGCKGKEMKGTFRLKGLSNGVYLTPVSFLIPSW SNNQELQNEIWENVVKKYGMLLDGDYISLKSNIIGFSEYYETLKFAYEFFYNYSLYLLKREEWDFAITYLPIVDN IQHLLFGVDDSQSLDYVFQVYKMADNFVKAHIELADNIIICSDHGINKVKKRLYLNKFLEELNVLKTVDDKKIDW KRTKAYYGGGGIIRINLREREKFGIVGKKEFNKLIKYLTINLERLEDPDTGERIFTVIYSNETPASDRQGDIMID GVNPKYSISSNIEKDTIFENVIPYRTTTADHGYYRNDDINGIIIFYGKNFTKKQVNMKIVDVTPTILKLYGINCK SDGKIVNEVFKNGHADSTK Sulfolobus solfataricus NYSGXRC-6191c SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3692 KLFCFKAIIFPIVGGSFNNGTNVFQSTVIVISLDGFRADYLYRGFTPNLLSLAERNVHVPFLIPSFPSITFPNHYT IVTGLYPESHGIVSNNFFDPVTGKQFVNSMPECNKDPTWWDKGEPIWVNAERNNVRSAVHMWPGNEVENHGYRPT YSDGFNFDTTLREKKDRILEWLDLPDKDRPQLLLAYAPHVDMVGHAFGPDSPELNIIIQEVDIVIGELIEGLKKR NIDKHVNIIFLSDHGMAPTSDNRLIWLDNMFNLSAVAHRDAWPLGGFRGESDLDDEYIYESLVNYSRSSLPSAEN WNVYSKKDIPSRWHYSNNERIAPVWMIPDVGWSLVSMLDHSPELEYEPLGVHGYDNLSPVMRALFIASGSSFKNF KGKKLAPFQNTEIYGILSHILDLPAQPNNGTYEGALPLRRNRNSTKEWLLKDIEQAYSKLI Schizosaccharomyces pombe NYSGXRC-6191d SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC3692 GENBANK NP_420090.1 REKAPHLTILVSIDGFRADYLDRGDTPVMKALAENGARAAMRPSFPSVTFPNHYTLITGKRPDRNGIVANTMVDPS VSAEKFTMRSLDPAWWSQAKPFWVSVEQQGKRAAAMFWPGSEVEIDGVRPSRWVKFDQTMPGDARVDQVLNWLDS ADGPPIAFSTLYFDIVDTQGHHYGPESPEVRAAAASVDAALGRLVAGLKARGRFESTDIVIVADHGMAPLPAANR VVLDDLVDVSKIRLVTTGAVTAFSPMPGERKAVEAAFLSKPLPHMTCWKKNRIPARFHYGRNSRVPAIVCLSETG WYTTTEAAKQKPSEWDGKDGGAHGFDPYDPTMQAVFVAHGPSFKSGVALPAFDNVDVYALLAKVTGVRPEKTDGS LKVVREALR Caulobacter crescentus NYSGXRC-6192a SGX Pharmaceuticals 2004-11-29 active Selected EC2233 MHLLRTQPGGFVPDDGIAHLAQTPAELVILCSGDSHLALLAEAARALPDDYPSLRLANPMQLQNHASVDLYVEEVL RHARVILLSLHGGIGYWRYGVEQLVALAERGALLIPVPGDDRPDPELSALGNLPAEQAERFWQYLRQGGLENAGQ FYRCLASQCLGRDYAWREPQALPRVALFHPRHAEATLEHWRADWQAGRPVVALLFYRTHLQAANTAFIARFCERL AAQGLNPLPIALASLKESACLAQVEDWLERSDAALIVNTTGFAQSNPEAPELRPFRRDVPVLQAICSLDNRPLWL DNPQGLGPRDLAMHVALPELDGRIVTRPISFKGLAWRSERSESDVVCYLADDERMDFVAELARRWAELARKPNAE KRVALVLANYPTRDGRIGNGVGLDTPAAALNILRALRQQGYPVDGLPASGTELIRQLLGGVSNDLEHLDLRPCAQ SLALDDYLACFARLPERNRQAVLARWGEPQQDPMFRDGRMMVAGLRYGLTFVGIQPARGYQLDPAAVYHDPDLVP PHGYLAFYFWLRHAYRADALLHVGKHGNLEWLPGKGVGLSAECWPDALLGPLPNIYPFIVNDPGEGAQAKRRTQA VIIDHLMPPLTRAESYGPLRDLERLADEFYDASLLDPRRAEQLRGEILVLLRDNRLDREIGLQLSDDPDSWLPQL DAYLCDLKESQIRDGLHVFGESPSGRLRLDTLLALLRVPRGDGKGANAGLLKSLADDLGLGFDPLACDMGEAWQG ARPACLEERGGEPWRTLGDTRERLELLALHWIERCLGGESPPATWRASGEVLRGLCEQVAPTLDACGGAEIDGLL AALEGRFVPAGPSGAPSRGRLDVLPTGRNFFSVDVRNLPTPTAWRIGFQSANLLLERHLQEHGDHLRQLGLSVWG TATMRTGGDDIAQALALLGVRPVWQAGSQRVADFEILPVSLLDRPRVDVTLRVSGFFRDAFANLIRLFDAAVQAV AELDEAEELNPLAARVRLERQRLEAQGTAPAEARRQAGWRIFGAKPGAYGAGVQGAIEERLWETRADLAEVYLNW GGYAYGAADDGTPARERFAQRLERLQAVLHNQDNREHDLLDSNDYYQFQGGMLAAVETLRGAPVASYHGDHSQPD NPRIRTLKEELNRVVRARAVNPKWIAGMKRHGYKGAFELAATVDYLCAFDATSELIDDHQYALLADAYLLDAETR EFVRQHNPQALRDMAERLVEAQRRGLWQEPGAYREALENLLLDVEEE Pseudomonas aeruginosa NYSGXRC-6192b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2233 MSSMLPSISPELARIAPGFRALSINVIAAPVRDAQVGEIALKEACQAVINGQPAWAQAHIDAWNAVFKAFGAKPKR TPCSAEALRKRVLKDGTMAALDPVVDLYNAVSLRYAVPVGGENSAAYCGSPRLVFADGSETFDTLKEGKPVTESP EPGEVIWRDDRGVTCRRWNWRQGVRTRLSASDKMMWFILESLPEMPVDELYAAENMLTDGLEKMMPGLRFESTLI GV Salmonella typhi NYSGXRC-6193a SGX Pharmaceuticals 2004-05-17 active Selected EC2609 GRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVARADMFTGRTIGIVARIL KIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGTTWCGRPGDDAGRPAARAGAGCSHRGCGAFYPAMFQAAI DAGRPVQPLRLTYHHVDGTVSTAPAFVGDDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNLARRCQSAVLAG ALGQSGQRPGRRHVPAT Mycobacterium tuberculosis NYSGXRC-6193b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2609 GPARKRALIQRWSRRLLALFRVTLAVDGEAVGQADLAGAMLVSNHVSWLDVYAINAWHSPRFVAKSEIRSWPVIGW LCAQTGVLFVERARKRDAHRIMHAIADALRGGESICVFPEGTTSNGMQLLPFHANLFQAPVTAAAPIRPVALRYR IAATGELTTIPAYIGDMSLLDSVNAILNGPPLVAEVFVGSAVSPEMDRRALAEHSRQAVATLMERAG Ralstonia solanacearum NYSGXRC-6193c SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2609 GENBANK NP_242501.1 MSIYSVGRWICRSYFRLFFKVEVIGASRIPDEGGLLLCCNHFSNYDPPFVGSFFPRKVRFMAKEELFRFKPLQSLM MAVGAFPVRRGAGDKQALKVGLKLLKEGETLGIFPEGTRSKDGQIGKGLSGVGFFALRSDATVVPCAIVGKYRFF RKVRFVIGEPVPMEELKERKASAEEATEVIMKAIRKLHEQNQMS Bacillus halodurans NYSGXRC-6193d SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2609 FDWRLRRRIPRIWHRIACHVLGIRVHVHGEVERAKPLMLAVNHASWKDILVLGSIADVVFIAKTEVRDWPVFGWLA RLQKSIFVQREQKRSTGQQVGEIASRMADGEIVVLFPEGTTSDGNRMLAVKSSLFGAASTAAEQVPGKLVYVQPV AIAYTRVQGMAMGRYHRIIAAWPGSITLVPHLLGVIKAGAIDVDVTFGDSVPFHSADNRKRLATDIAAAIRSMLA FSLRGGWRK Agrobacterium tumefaciens NYSGXRC-6194a SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC961 GENBANK NP_208197.1 MQEIFLCSISNVRSGDCKEDCAYCTQSSHHQGAIKRYKFKDEKVVLQEARALRQLGALGFCLVTSGRELDDEKCEY IAKLAKAINQEELGLHLIACCGRADLEQLEFLRDAGIHSYNHNLETSQNFFPKICSTHTWEERFITCENALRAGL GLCSGGIFGLNESWEDRIEMLRALASLSPHTTPINFFIKNPVLPIDAETLSADEALECVLLAKEFLPNARLMVAG GREVVFKDNDKKEAKLFEYGINAVVLGDYLTTKGKAPKKDIEKLLSYGLTMATSCH Helicobacter pylori NYSGXRC-6194b SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC961 ICEDB: T1926 GENBANK NP_249191.1 MSATASVATRHDWSLAEVRALFEQPFNDLLFQAQTVHRAHFDPNRVQVSTLLSIKTGACPEDCKYCPQSGHYNTGL DKEKLMEVQKVLEAAAEAKAIGSTRFCMGAAWKHPSAKDMPYVLEMVKGVKKLGLETCMTLGRLTQEQTQALADA GLDYYNHNLDTSPEFYGNIITTRTYSERLQTLAYVREAGMKICSGGILGMGESVDDRAGLLIQLANLPEHPESVP INMLVKVKGTPLAEEKDVDPFDFIRTLAVARIMMPKSHVRLSAGREQMNEQMQALAFMAGANSIFYGEKLLTTKN PQAEKDMQLFARLGIKPEEREEHADEVHQAAIEQALVEQRESKLFYNAASA Pseudomonas aeruginosa NYSGXRC-6194c SGX Pharmaceuticals 2004-07-06 active Selected EC961 MSSIIRYDWTAEELHALFDLSLPELLYRAASVHRQHFDPAEIQVSTLLSVKTGGCPEDCSYCPQAQRYDTGVTAQK LMDVDAVVAKARQAKLAGASRFCMGAAWRSPKDRDIPKIAAMIREVKALGLETCATLGMLNTCQAQALKDAGLDY YNHNVDTSPDFYDSVIHTRQYQDRLDTLAHVRDVGLKTCCGGIVGMGETRQHRVGLLLTLATLPAHPDSVPVNLL VQVAGTPLHGTQTLDPFEFVRMIAVARITMPRSMVRLSAGRESMSDELQLLCFMAGANSIFYGEKLLTTANPETE RDQALFQRLGLRPMHLMENVSNQDQHHGNVHADIACKHVV Xylella fastidiosa NYSGXRC-6194d SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC961 MFTRTIRQQIRRSSALSLVRNNWTREEIQKIYDTPLIDLIFRAASIHRKFHDPKKVQQCTLLSIKTGGCTEDCKYC AQSSRYNTGVKATKLMKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNRTFKNILEIIKEVRSMDMEVCVTLGM LNEQQAKELKDAGLTAYNHNLDTSREYYSKIISTRTYDERLNTIDNLRKAGLKVCSGGILGLGEKKHDRVGLIHS LATMPTHPESVPFNLLVPIPGTPVGDAVKERLPIHPFLRSIATARICMPKTIIRFAAGRNTCSESEQALAFMAGA NAVFTGEKMLTTPAVSWDSDSQLFYNWGLEGMQSFEYGTSTEGEDGTFTLPPKERLAPSPSL Schizosaccharomyces pombe NYSGXRC-6194e SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC961 GENBANK NP_011802.1 MMSTIYRHLSTARPALTKYATNAAVKSTTASSEASTLGALQYALSLDEPSHSWTKSQLKEIYHTPLLELTHAAQLQ HRKWHDPTKVQLCTLMNIKSGGCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKEAEEAKRNGSTRFCLGAAWRDM KGRKSAMKRIQEMVTKVNDMGLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIK NVQESGIKACTGGILGLGESEDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTI ATARIVMPKAIIRLAAGRYTMKETEQFVCFMAGCNSIFTGKKMLTTMCNGWDEDKAMLAKWGLQPMEAFKYDRS Saccharomyces cerevisiae NYSGXRC-6195a SGX Pharmaceuticals 2004-07-01 active Selected Cloned Expressed Soluble Purified EC2621 ICEDB: T1889 GENBANK NP_115315.1 MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIY KMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKS GFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFK TKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRD IASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFS CNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIE TIVYGIKNIKQEFIENGRKEIYKRTYKD Enterococcus faecalis NYSGXRC-6195b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble Purified EC2621 ICEDB: T1890 GENBANK NP_349180.1 MQSESLVIRRAEEGDAYQIIRLVKQVIKESPFFERTPEEFNFTVEDEQEYIKNTELFIVVEVDGKIVGSATLKRSS LSMLRHTALFGITILKEYSGKGIGSLIIKRVFEWAEENAIEKIDLEVFHDNFKAISLYKKFGFIEEGRKKNAIKA EDGYKDLVLMGRFSKA Clostridium acetobutylicum NYSGXRC-6195c SGX Pharmaceuticals 2004-07-15 active Selected Cloned Expressed Soluble Purified EC2621 ICEDB: T1891 GENBANK NP_241165.1 MNISFIASNTLHELAAFLEKLNNIREHHVGFCGEKGSEIKATLERDFSDIGVSKSFIVGYDGMEIKGAVGLDVDTK EESAEVWGPFVDEDDPEMWLDTATILWQQLIDSLTVPVSTFQFFINQHNVNAKKFILKLNGMEKGDHDILTCDRT QFYPPLNHDVRLFTNNHTQSFKKLHDSLFPQTYYDAEEILKKINEPTNKLLIIEKEQIVIGYAYVEVEPEHGEGQ IEYIGIAPDYRRQGLATQLLTNALHVLFSYPTVEDITLCVSKQNTKAIRLYQAAGFKKERQLTYFELNVDGLDNR RGRG Bacillus halodurans NYSGXRC-6195d SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2621 MKIAIITDGSVEMGMGHVYRTLSLANELRKFNVNEIIFFTKSDEDVIKKIEENGFKVIKCSDNNDILKNIKNIKPD VVIIDDLGIEEDFAKNIRELCKKLIFFDNPNPSSNKYADIVVNAIVGSELKNRKYFDEENKTLYFYGPKYLILRN EFYKVKKEMLSRSKNKETKNILIAFGGSDPSNLTCKVLEELLSKDRDFNINVVLGPKFQYEDELNNLLKRYSKSD KIKIYKNIDNMAELMKDNDLIITSPGMTMFEALFLGIPVVVLYQNELQRECYDDYLKKISKTHLNPLKEGYFIDA EHTDLHIGKGKFEIIEAITNIYNCKKIGEDSKIIIRQITDNDLELLMAWRSNPLIYKFFYIQKEPLKWEEHYSWW MSRENRVDWIILLRENNTIRKVGSVNVSQLNTDNPEIGILIGEFFLWGKHIGRHSVSLVLKWLKNIGYKKAHARI LENNIRSIKLFESLGFKKTKKGRENEWIYEVNL Methanococcus jannaschii NYSGXRC-6195e SGX Pharmaceuticals 2004-07-06 active Selected Cloned EC2621 GENBANK NP_490121.1 VINLRPATLADLNLLRHWDEQPHVIASDPNDDWGWEVELARSPDWREQLIVEIDSRPIGFIQIIDPAQEDSHYWGD VGENLRAIDIWIGEETDLGKGYGTQMMRLALARCFADPLVTAILVDPLASNTRVHRFYERLGFKFIEHRCFGDDE CFVYRLNREDWHCKSEVYV Nostoc sp. NYSGXRC-6196a SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC3365 GENBANK NP_337159.1 VTNVAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTTNPVLEPLVAVHRE IYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEE FGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEV IAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHY WSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEG KPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLA VQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDW QQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEG HVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVT RGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNILSASVTTS GDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA Mycobacterium tuberculosis NYSGXRC-6196b SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3365 MAELSDLLEKIDENCNNVDKDIVIKAYNFAYEAHKHQMRESGEPYISHPLDVACILAEMGMDMSTIVAGILHDVIE DTSYSYDDITEMFSKEVADLVSGVTKLDKITYKTKEEQQADNVRKMLLAMAKDIRVILIKLADRLHNMRTLKFKR EQKQKEKAKETLDIYAPLAHRLGMSKIKWELEDLSFRYLKPKEYYELVDLIAEKRVEREEYISKIVEELKLNLEA SGITPDIDGRPKHFYSIYRKMLNKSKSLDQIFDLTAVRILVNNIKECYAALGIVHTMYKPIPGRFKDYIAMPKPN MYQSLHSTVIGPEGKPFEIQIRTYDMHKTAEYGIAAHWKYKEGTIESTQNVPQNKNANKDDTKLTWIREMLEWQR ETPSAQEFMENFKIDLFSDEIFVFTPKGKVINLPYNATPVDFAYKIHTDIGNRCVGAKVNGKIVPLDYKLKTGEI VDILTTSLVKGPNINWLNSVTSNQAKSKIRSWFKKAKRDENISKGKELLEKESKKQEFNFGEIAKGENLELVLKR YNMNSIDDLYASVGIGAVGASVILSRFKDIYEKNKDNGSLTNEEVLENVNKNIHKEHSSKKISKSEQPGVTVKGV SDVLVRFAKCCTPVPGDPIIGYITKGRGVSVHRTDCTNVNNLIKEDSSRIIEVKWGKSKNESYMAEVEIKAEDRQ ALLADVVEVISYMEIAIESVNAKTSKGSAYLNLKLKIQDVEHLALLMKKLRRLPGIIDIYRTNS Clostridium acetobutylicum NYSGXRC-6196c SGX Pharmaceuticals 2004-07-02 active Selected Cloned Expressed Soluble Purified EC3365 GENBANK NP_815650.1 MPKEEILTGPAVIKIVSTYMGPEHVELVQKALTYAEKAHEGQVRQSGEPYIIHPIQVAGILAELHMDPHTVATGFL HDVVEDTDVTLDDLKEEFGEDIAMLVDGVTKLGKIKYKSHEEQLAENHRKMLLAMAQDLRVIMVKLADRLHNMRT LKHLREDKQRRIAQETLEIYAPLAHRLGISRIKWELEDTALRYINPNQYYRIVNLMQSKRDEREAYVAEAVEDIR LATEDLEIYAEIYGRPKHIYSIYRKMKDQKKQFNEIYDLLAIRVIVDSIKDCYAVLGAIHTRWTPMPGRFKDYIA MPKANMYQSIHTTVIGPKGNPVEVQIRTHEMHQIAEFGVAAHWAYKEGKAEKIETDELTKQVDWFHEIIELQDES YDASEFMQGVKEDIFSDKVYVFTPSGDVTELPKGSGPLDFAYSIHTEIGNKTTGAKVNGKMVQLDYVLKNGDIIE VLTSPNSFGPSRDWLKMVKTSKAKNKIKRFFKEQDREDNIIKGHDAVIKYMTEIGFTPKEFLTKNKMAEVLDKFK FQTEDDLFAAVGYGEVSAQVVCNRLTEKERREQELERQRQEAEELLNQPAKKESEKMKVRHEGGIVIQGVDNLLI RLSRCCNPVPGDEIVGYITKGRGVSIHRADCPNVQHQEELAQRLIEVEWEDTEHSRKEYAADLEIYGYDRSGLLS DVLQVISSMTKNLVGVEARPSKDKMAQIHVTVKIQNLSHLKTIVDKIKSVPDVYSVRRTNG Enterococcus faecalis NYSGXRC-6196d SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3365 MPAPQPSAPYDPLTAEARALLFHTASYLKPEEQAELEKAVAYAFRAHDGQTRKSGEPYITHPIAVATQLALWHMDI QGLCAGVMHDVLEDTGVTKGEMAAVFGNTIAEMVDGLSKLEKLKFEDHAEHQAESFRKLILAMTKDVRVIVVKLA DRLHNMRTLGSMRPDKRRRIARETLEIYAQIANRIGLNNAYQELQDLSFQNLHPNRYETLKKAMDKSRKNRQDVV GKVLRAFGQRLVGANIEAKIKGREKNLYGIHQKMMAKKLRFAEVMDIYGFRVIVNSIPACYAALGALHTLYQPKP GRFKDYIAIPKSNGYQSLHTTLVGPYGLPIEVQIRTKEMDAVAEGGIAGHWSYKSYSKTVDQAVLHTNRWLKNIL DLQASSANAIEFLEHVKVDLFPNEIYILTPKGKILTLPKGATPVDFAYAVHTDIGHKTVAARINNIMMPLRTKLK TGDSVEIITSEHAKPNPAWLNFAVSGRARSAIRQYIKNLNRHDAVVLGESLLQKALSSLLPKDVLLSDGIKEKYL ADLNDKQTSFEEVLYNVGMGHTLPVYVAMHIAELAGEHFGSEVRLSSIKVDGQESGHIHFAECCHPVPGDSIRLL LVKGKGMIIHRDTCPTLLKSDPEQQLDADWENMNGQNYRVGLQVQSEDSHGLLALMAQAISDSGADIESVETPSK SQSGTEGFVEFKFLLKVKNLNQLNQIIQNLHSIPYIRKVIRS Neisseria meningitidis NYSGXRC-6197b SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC1512 LREGRLRATSLAMKKMLTCGVIAAAVSVGFAAQAQSTATKPAPKLVVVISIDQFSANLYAQHRPEFTGGLKQLSAG IVYPNGYQSHAFTETCPGHSTLLTGKHPNKTGISANDWYDKTTGKTVYCLADPSVTLADDPKGRAVSPANMVATT YGDWLKAVSPNSRVFGVSGKDRGAITMSGHAADGQFWYQPGFGFTTYVRPGQTAEARLKPVAAFNAKLAADLKKQ PFVWDYAKSPLDAVTGGGSAKRCKALEADYETGGRKWRAALPIPAATTEAEKRRDLAASPYTDQVTLELATALRE AYGLGDGPQVDVLAISLSATDYIGHRYGTRGPEMCDQIARLDERLGAFLKGLEKVKGGVLVALSADHGGADMAER LHGEGYDYERVIGKPWIAKLNAQVRAQLGLSWDPLNAEGGLDQIYVVGPDGKATSDIDRTRITAAALPLIISDPA VAGAFDSNALLTLPPAPADASPEELSLAERLRRSVYPGRVGDIVVAFRPDRVPATAGPTYVSTHGSPWDYDRRVP ILFWWKGAAPHERVLPLDTVDIAPTIAAVTGVTPPADIDGKCRPLVYGQRC Caulobacter crescentus NYSGXRC-6197c SGX Pharmaceuticals 2006-08-03 active Selected Cloned Expressed Soluble Purified EC1512 ICEDB: T1864 GENBANK NP_242396.1 VDVKRFKRVFLIVMDSVGIGEAPDAKAFGDQGAHTLGHIAERMNGLHMPNMAALGLSHIRPIQGIEKVDKPKAHYG IMQEISSGKDTMTGHWEIMGLHIREPFRVFPNGFPEELLNEIRELTGREILGNKVASGTEIIKELGDEHVKTGAL IVYTSADSVLQIAAHEEVVPLEELYDICKKVRALTLDPKYMVGRIIARPFIGADGNWERTSNRHDYALKPFGRTV MNELKDAGFDSIAIGKISDIYDGEGVTESIRTISNDDGMEKLVRSMDQSFTGLSFINLVDFDAKYGHRRDPIGYG QALEQFDQQLADVVEKIGEEDVLIITADHGNDPVHHGTDHTREFVPLLVYTRGIKEGKDLGLRKTFADVGATIAD NFQVEAPSIGTSFLHEL Bacillus halodurans NYSGXRC-6197d SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC1512 ICEDB: T1927 GENBANK NP_341955.1 LKQYKILLIVADGLGDRPVSKLNGLTPLEAANKPAITDLLKNSMIGLMDPISPGIIPGSDTSHLSIFGLDPHVYYR GRGAFEALGAGATLSHGDVAFRGNFATVNNDLVVVDRRAGRKLEEGEQLVKELNEKIKEINDVKIKFYKGTEHRI AVVLSGKGISDKVSDTDPHHEGLKVLESKPLEDSNEAIRTAEIINILTRKVFDVLNSSEINKRRIEQGEKPANIV LLRGAAHYVKLPPFSSYTKLKAAAVSATALIKGICRELGMNVITPSGATGGIDTNYNAKAKAAIELLKENDFVFL HIKATDAASHDGLVEEKVKAIERIDRVIGAIIDNIGRDNLILMFTGDHVTPVEIKEHTGDPVPVLLYVPYPIIND NVGDFNEKEARKGSLRIRGLDVTNILLNYSNRAEKYGS Sulfolobus solfataricus NYSGXRC-6197e SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC1512 MAELNFKAIEEKWQKRWLEAKIFEPNIRDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLF PMAWHITGSPIVGIAERIKNRDPKTIWIYRDVYKVPEEILWTFEDPINIVKYFMKAAKETFIRAGFSVDWSREFY TTSLFPPFSKFIEWQFWKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGEDVPILDYIIIKFELRENGEVIYLP AATLRPETVYGVTNMWVNPNATYVKAKVRRKDKEETWIVSKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVS GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRETEILEKYDIDPRIVENITYISLIKLEGYGDFPAV EEVNKLGIKSQKDKEKLEQATKTIYKAEYHKGIFKVPPYEGKPVQEVKEAIAKEMLEKGIAEIMYEFAEKNVISR FGNRAVIKIIHDQWFIDYGNPEWKEKARKALERMKILPETRRAQFEAIIDWLDKKACARKIGLGTPLPWDPEWVI ESLSDSTIYMAYYTISRHINKLRQEGKLDPEKLTPEFFDYIFLEEFSEDKEKELEKKTGIPAEIIHEMKEEFEYW YPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLY IMSLAEHDSDFDWRRKEVGKLRKQIERFYELISQFAEYEVKGNVELKDIDRWMLHRLNKAIKETTNALEEFRTRT AVQWAFYSIMNDLRWYLRRTEGRDDEAKRYVLRTLADVWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVEE WWNETIEAEEEFIRSVMEDIKEIIEVAKIENAKRAYIYTAEDWKWKVAEVVSEKRDFKSSMEELMKDSEIRKHGK EVAKIVQKLIKERTFDVKRINEEKALREAKEFMEKELGIEIIINPTEDKGGKKKQAMPLKPAIFIE Pyrococcus horikoshii NYSGXRC-6197f SGX Pharmaceuticals 2006-08-10 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC1512 ICEDB: T1865 PFAM PF01676 PDB 3M7V GENBANK NP_721612.1 MSTFNRIHLVVLDSVGIGAAPDANNFSNAGVPDGASDTLGHISKTVGLNVPNMAKIGLGNIPRDTPLKTVPAENHP TGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEIISKIEKFSGRKVIREANKPYSGTAVIDDFGPR QMETGELIIYTSADPVLQIAAHEDVIPLDELYRICEYARSITLERPALLGRIIARPYVGKPRNFTRTANRHDYAL SPFAPTVLNKLADAGVSTYAVGKINDIFNGSGITNDMGHNKSNSHGVDTLIKTMGLSAFTKGFSFTNLVDFDALY GHRRNAHGYRDCLHEFDERLPEIIAAMKVDDLLLITADHGNDPTYAGTDHTREYVPLLAYSPSFTGNGVLPVGHY ADISATIADNFGVDTAMIGESFLDKLI Streptococcus mutans NYSGXRC-6198a SGX Pharmaceuticals 2004-07-16 active Selected Cloned Expressed Soluble Purified EC2574 ICEDB: T1928 GENBANK NP_370536.1 LFKEERTMTNYTVDTLNLGKFITESGEVIDNLRLRYEHVGYHGQPLVVVCHALTGNHLTYGTDDYPGWWREIIDGG YIPIHDYQFLTFDVIGSPFGSSSPLNDPHFPKKLTLRDIVRANERGIQALGYDKINILIGGSLGGMQAMELLYNQ QFEVDKAIILAATSRTSSYSRAFNEIARQAIHLGGKEGLSIARQLGFLTYRSSKSYDERFTPDEVVAYQQHQGNK FKEHFDLNCYLTLLDVLDSHNIDRGRTDVTHIFKNLETKVLTMGFIDDLLYPDDQVRALGERFKYHRHFFVPDNV GHDGFLLNFSTWAPNLYHFLNLKHFKRK Staphylococcus aureus NYSGXRC-6198b SGX Pharmaceuticals 2004-05-17 active Selected EC2574 VTAVLAGHASALLLTEEPDCSGPQTVVLFRREPLLLDCGRALSDVRVAFHTYGTPRADATLVLHALTGDSAVHEWW PDFLGAGRPLDPADDYVVCANVLGGCAGTTSAAELAATCSGPVPLSLRDMARVGRALLDSLGVRRVRVIGASMGG MLAYAWLLECPDLVEKAVIIGAPARHSPWAIGLNTAARSAIALAPGGEGLKVARQIAMLSYRSPESLSRTQAGQR VPGVPAVTSYLHYQGEKLAARFDEQTYCALTWAMDAFQPSSADLKAVRAPVLVVGISSDLLYPAAEVRACAAELP HADYWELGSIHGHDAFLMDPQDLPERVGAFLRS Deinococcus radiodurans NYSGXRC-6198c SGX Pharmaceuticals 2004-07-15 active Selected Cloned Expressed Soluble EC2574 GENBANK NP_249081.1 MPTVFPDDSVGLVSPQTLHFNEPLELTSGKSLAEYDLVIETYGELNATQSNAVLICHALSGHHHAAGYHSVDERKP GWWDSCIGPGKPIDTRKFFVVALNNLGGCNGSSGPASINPATGKVYGADFPMVTVEDWVHSQARLADRLGIRQWA AVVGGSLGGMQALQWTISYPERVRHCLCIASAPKLSAQNIAFNEVARQAILSDPEFLGGYFQEQGVIPKRGLKLA RMVGHITYLSDDAMGAKFGRVLKTEKLNYDLHSVEFQVESYLRYQGEEFSTRFDANTYLLMTKALDYFDPAAAHG DDLVRTLEGVEADFCLMSFTTDWRFSPARSREIVDALIAAKKNVSYLEIDAPQGHDAFLMPIPRYLQAFSGYMNR ISV Pseudomonas aeruginosa NYSGXRC-6198d SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2574 MSVQNVVLFDTQPLTLMLGGKLSHINVAYQTYGTLNAEKNNAVLICHALTGDAEPYFDDGRDGWWQNFMGAGLALD TDRYFFISSNVLGGCKGTTGPSSINPQTGKPYGSQFPNIVVQDIVKVQKALLDHLGISHLKAIIGGSFGGMQANQ WAIDYPDFMDNIVNLCSSIYFSAEAIGFNHVMRQAVINDPNFNGGDYYEGTPPDQGLSIARMLGMLTYRTDLQLA KAFGRATKSDGSFWGDYFQVESYLSYQGKKFLERFDANSYLHLLRALDMYDPSLGYDNVKEALSRIKARYTLVSV TTDQLFKPIDLYKSKQLLEQSGVDLHFYEFPSDYGHDAFLVDYDQFEKRIRDGLAGN Haemophilus influenzae NYSGXRC-6199a SGX Pharmaceuticals 2004-07-06 active Selected Cloned EC2166 GENBANK AAK01510.1 MSSHTALPIEPLDVLIIGAGVSGIGAAAYLRRHQPHKVFAILESRERMGGTWDLFRYPGIRSDSDLYTFGFDFKPW TKAKSLADAADILEYLREAVAEYQLDPFIQYRQKVVSANWQSDKGLWAVCVEDGHTAETRTIECRWLFSAGGYYR YDQGFSPRFEGAEQFKGQIIHPQHWPERLDYRGKHVVVIGSGATAVTLIPAMADEVASITMLQRTPSYIVNQPAN DSVAAFLRKILPAQTAYSLTRYKNAKITLVFWRFCQRFPGLARKLLIWLTRRELPKGYPVDVHFNPPYKPWDQRL CSVPEGDLFKAISAGKASVVTDHIERFTESGVLLKSGTELKADIIITATGLNVQLFGGIALHKDGEPVVLSQTLA YKGTMLSGVPNFAFAVGYTNSSWTLKVCLLCDHFCRLLGFMDSQGHNVCEPKAPDGVETRPLLDFGAGYVQRALD GMPRQGPREPWVMSMDYFRDIKLLRRGKVADECLRFSTVPDAYLHRSVALQTQGGGR Pseudomonas aeruginosa NYSGXRC-6199b SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2166 MSASALLDNQCDHFSTKMVDLIMVDKADELDRRVSDAFSEREASRGRRITQISGECSAGLACKRLADGRFPEISAG EKVAALSAYIYVGKEILGRILESEPWARARVSGLVAIDLAPFCMDFSEAQLLQTLFLLSGKRCASSDLSHFVAIS ISKTARSRTLQMPPYEKGTTKRVTGFTLTLEEAVPFDMVAYGRNLMLKASAGSFPTIDLLYDYRSFFDQCSDSGR IGFFPEDVPKPKVAIIGAGISGLVVASELLHAGVDDVTIYEASDRVGGKLWSHAFKDAPSVVAEMGAMRFPPAAS CLFFFLERYGLSSMRPFPNPGTVDTNLVYQGLRYMWKAGQQPPKLFHRVYSGWRAFLKDGFHEGDIVLASPVAIT QALKSGDIRRAHDSWQTWLNRFGRESFSSAIERIFLGTHPPGGETWSFPHDWDLFKLMGIGSGGFGPVFESGFIE ILRLVINGYEENQRMCSEGISELPRRIATQVVNGVSVSQRIRHVQVRAIEKEKTKIKIRLKSGISELYDKVVVTS GLANIQLRHCLTCDTTIFRAPVNQAVDNSHMTGSSKLFLLTERKFWLDHILPSCVLMDGIAKAVYCLDYEPQDPN GKGLVLISYTWEDDSHKLLAVPDKKERFCLLRDAISRSFPAFAQHLVPACADYDQNVVQHDWLTDENAGGAFKLN RRGEDFYSEELFFQALDMTNDTGVYLAGCSCSFTGGWVEGAIQTACNAVCAIIHNCGGILAKDNPLEHSWKRYNY RNRN Agrobacterium tumefaciens NYSGXRC-6199c SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2166 GENBANK NP_218371.1 MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIA DGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRF AGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLN RWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDL FRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSG IPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQGS RTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV Mycobacterium tuberculosis NYSGXRC-6199d SGX Pharmaceuticals 2004-06-23 active Selected Cloned Expressed Soluble Purified EC2166 ICEDB: T1866 GENBANK NP_390176.1 MIQGKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNYPTHQTFFSSSEKLEIGDVAFITENRKPVRIQA LSYYREVVKRKNIRVNAFEMVRKVTKTQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKE GHPYFDKDVVVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFGACVEKITE NEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFNEETMETNVEGVFIAGVIAAGNNANE IFIENGRFHGGHIAAEIAKRENH Bacillus subtilis NYSGXRC-6200a SGX Pharmaceuticals 2004-07-14 active Selected Cloned Expressed Soluble EC2549 GENBANK NP_216067.1 VTAREVGRIGLRKLLQRIGIVAESMTPLATDPVEVTQLLDARWYDERLRALADELGRDPDSVRAEAAGYLREMAAS LDERAVQAWRGFSRWLMRAYDVLVDEDQITQLRKLDRKATLAFAFSHRSYLDGMLLPEAILANRLSPALTFGGAN LNFFPMGAWAKRTGAIFIRRQTKDIPVYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGILRYITDAV DEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLARQQGERLGRAYLDFGEPLPLRKRLQEMR ADKSGTGSEIERIALDVEHRINRATPVTPTAVVSLALLGADRSLSISEVLATVRPLASYIAARNWAVAGAADLTN RSTIRWTLHQMVASGVVSVYDAGTEAVWGIGEDQHLVAAFYRNTAIHILVDRAVAELALLAAAETTTNGSVSPAT VRDEALSLRDLLKFEFLFSGRAQFEKDLANEVLLIGSVVDTSKPAAAADVWRLLESADVLLAHLVLRPFLDAYHI VADRLAAHEDDSFDEEGFLAECLQVGKQWELQRNIASAESRSMELFKTALRLARHRELVDGADATDIAKRRQQFA DEIATATRRVNTIAELARRQ Mycobacterium tuberculosis NYSGXRC-6200b SGX Pharmaceuticals 2004-07-06 active Selected EC2549 MIEFFSVSDTHQTQPTNRLVHPQVAVTTSRVSPWLSPVLYFVGNYFLLPSFFGRISITGQENIPKTGPVILAPTHR ARWDSLLLPYATGRYVTGRDLKFMVTKTECRGLQGWFVRRMGGFPIDTQHPAVSTLRHAVELLQQGQMLVIYPEG NIFRDGKLHPLKSGISRLALSAESSHPGLGVKILPISINYSQPYPCWGTDVSIHIGSPINVQDYTKGKVKQNAKR LTEDLARDLQSLSNPELAFSHHDAAEVSTSPIVSVSDSTERSPNVRGGATSRKRELLTIDY Nostoc sp. NYSGXRC-6201a SGX Pharmaceuticals 2004-05-17 active Selected EC4077 MGKLSVLVLLIVQAFYFSTQVSAVTFSDLNGSNGISSPELSKKQGISIIRIDVPWSEIESVKGNYDYTKYDNEIIR AKKLGYDVLPVLAYAPVWNKSIKGKIGSPPLETSSWNGFVESTVKRYRAYPYNITYFQVWNEPTLKAKFWLGNNE DFVNKIYIPAAKIIKKNNGKVVFGGWPLSNSISEFDYVLEGLGAIKYTDIIDIHYRGYKSYIKLYDKYIKTNKAD GIWQSELGYSSKPGNLLSSYLKIMSWALSHNWAKSDTYKIFWYPAWASREKKQYGLATTLKDGTTVLTENGNELV LLNDLYGSGELAVQDVQSNMKSSIDTDDYFFGVKISPNRIVIAVLYNGHVDYNQLNYSLMTKNNPRHITLVSSKR KQYQLDHTYEKGVTHIFVDKDKIRSISKGYSDVLFIKVEL Escherichia coli NYSGXRC-6201b SGX Pharmaceuticals 2004-06-29 active Selected Cloned Expressed Soluble Purified EC4077 ICEDB: T1867 GENBANK NP_349646.1 SKTSKMKKTEISKKPSELGISNKTQDDLSKYSDTVNIALFGVDRRLKTDVSRSDSIMILTMDPAHKKLKLSSIMRD TYVNVDGHGMTKITHAYAYGGPQLAIKTINENFKLNIKDYVTVDFYALEKIIDKLNGVEINVQSDEVGYLNGYID EVSKYEKVTPNHVTSSGKQLLDGRQAVAYSRIRYTAGGDFVRTERQRTVLMAVFNKLQAQGKSNMVSMFDEILPY TETNMGSIDIAKYGTKFISSDISNIDQERFPLDGYCSGVTVDNVWYLKTDLNVTSDQMRKYIFEDVKPSPKASLV NIPEK Clostridium acetobutylicum NYSGXRC-6202a SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC397 GENBANK NP_228936.1 MFLEKLVEMARGKGKKLAVAAANDDHVIEAVYRAWRERVCEPVLFGPEEEITRIIEELVPEWKNPQIIDCPPEEAG RLAVEAVSKGECDFLMKGKIKTGDLMKIYLDERYGLRTGKTMAMVSVMEIPDFPRPLIISDPGMLISPTLEQKVD MIEHCVRVANVMGLETPKVAVVGAIEVVNPKMPITMEAAILSKMNQRGQIKGCIVDGPFALDNVVSEEAAKKKGI QSPVAGKADILILPDIEAANILYKALVFLAKAKSASTILGGKVPVVLTSRADSEETKFYSIALSAVFA Thermotoga maritima NYSGXRC-6202c SGX Pharmaceuticals 2004-12-04 active Selected Cloned Expressed Soluble Purified EC397 ICEDB: T2208 GENBANK NP_349676.1 VIKSFNEIIMKVKSKEMKKVAVAVAQDEPVLEAVRDAKKNGIADAILVGDHDEIVSIALKIGMDVNDFEIVNEPNV KKAALKAVELVSTGKADMVMKGLVNTATFLRSVLNKEVGLRTGKTMSHVAVFETEKFDRLLFLTDVAFNTYPELK EKIDIVNNSVKVAHAIGIENPKVAPICAVEVINPKMPSTLDAAMLSKMSDRGQIKGCVVDGPLALDIALSEEAAH HKGVTGEVAGKADIFLMPNIETGNVMYKTLTYTTDSKNGGILVGTSAPVVLTSRADSHETKMNSIALAALVAGNK Clostridium acetobutylicum NYSGXRC-6203a SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3742 VTLIYGHRGAKGEAPENTLASFQRCLEHGVNRCELDLHLSRDGELMVIHDPTLKRTTGRRGKVAEHDAATLATYDA RKGGPGWVRPTPIPRLEELFEKCPFEHWQLEVKSASRERAARTVTRIRELTERFGNRDKVTVTSGSRTVLKALNE LTPELSRGLVAEYAWLDPLKVAQHYGCALLALNWTLCTPERLLKAQRQGLHVSVWTVNEPALMRRLADFGVDSLI TDFPGLASATLGNR Pseudomonas aeruginosa NYSGXRC-6203b SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC3742 MKYSDISEVKLISGGPIPSLSEVLERYSSMNYFIEIKVEHFDNKAARLVDLVANNIYASRLIDRSIVISFSGEAID YLTEHYPDIRSGLDFDDPGLLEDAQSKYGVLLPHYFLISQDFCRNLRKPVIPWTVDDVELANKLKKLGCKGIITN VGDRMLSAIK Thermoplasma volcanium NYSGXRC-6204a SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC810 GENBANK NP_388261.1 MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAEDTKVTDLLIACAEQYLATGSAPELAEAVVERY ALIANELQLGQSIIEKIRDDLFTLLEGDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVT NEPGNAQVLPESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENFTDVDAVYS VNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKNTNNPSAEGTRVVSKRDNTNGPVVGI ASDTGFCSIYISKYLMNREIGFGRRALQILEEHGLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHAD EVIVEHHLALIMVVGEAMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAGV LIS Bacillus subtilis NYSGXRC-6204b SGX Pharmaceuticals 2004-08-27 active Selected Cloned Expressed Soluble Purified EC810 ICEDB: T1868 PFAM PF00696 GENBANK NP_346919.1 MKIVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQ RYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKSGCFDEKKS YEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTI SKISYKELRELSYMGATVLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIA IEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALV ATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFN Clostridium acetobutylicum NYSGXRC-6204c SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble EC810 GENBANK NP_069534.1 MRIVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPSAGFIKMFIADMMKRHY EAIEYAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRSEDYIVSFGERLSAPIFSAALLSLGVDSVALT GGDAGIITDRNFGRAKPLPGVYTTIRNRLEPLLTIKKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDA DEVWLWKEVDGIMTCDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDAPGTVI GPTTKDSSEIVKALSLIPQAGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVAQSSSELNLSIVVDIRDLEKAY NALKSLENGVIKVEKIPYIAVVSAVGSGMAGTPGVAGKIFSALGKNGINVIMISQSCSEYNVSFVVDGSDGVNAV KVVHDEFGLGN Archaeoglobus fulgidus NYSGXRC-6205a SGX Pharmaceuticals 2004-12-15 active Selected Cloned Expressed Soluble EC1677 GENBANK NP_248434.1 MDVEDTVKKLNLKFRNIEGERLILAITCDENKNVLMVAFMNEEALKKTLETGYMHYYSTSRKKLWRKGEESGNVQK LIKFYRDCDGDALLFIVEQKGVACHEGYYSCFHYKIEDGELKITGEYYSKR Methanococcus jannaschii NYSGXRC-6205b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC1677 MSRKWLNKVKWDDHGLVPVIVQEQGSNDVLMFAFMNREALQKTVETGEAVFWSRSRKRLWHKGEESGHIQQVHEIR LDCDEDVVLLRVTQVGGIACHTGRHACFFQKFEGTAEDGDWHTVEPVLKNPDDIYAGKPGHNHE Ralstonia solanacearum NYSGXRC-6206a SGX Pharmaceuticals 2004-07-06 active Selected EC1659 MSDTLTRLAAVLEERKNAAPDSSYVASLYHKGLNKILEKVGEESVETIIAAKDAAASGDCQDLIYETADLWFHSLV MLSALGQHPQAVLDELERRFGLSGHAEKAARQPSA Pseudomonas aeruginosa NYSGXRC-6206b SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC1659 ICEDB: T1915 GENBANK NP_273647.1 MGDSVLSAIQQTITQRKSANPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKNPSHLVYEVADLWFHTMILLT HHDLKAEDVLDELARRQGLSGLVEKAARTES Neisseria meningitidis NYSGXRC-6206c SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC1659 MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLMLGYMNPQALDKTIESGHVTFFSRTKQRLWTKGETSGHVLNVVS IAPDCDNDTLLVLANPVGPTCHKGTSSCFGDASHQWLFLYQLEQLLAERKTADPTSSYTAKLYASGTKRIAQKVG EEGVETALAATVNDRFELTNEASDLMYHLLVLLQDQDLNLTTVIDNLRKRHQ Salmonella typhimurium NYSGXRC-6206d SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble Purified EC1659 ICEDB: T1916 GENBANK NP_228841.1 VMTLYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEIRRDCDDDAYLYIV DFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEMPEGSYTVKLFKEGKGKIAKKFGEEAVEV ITGYLQNDRENLVWEIADMMYHLTVLMADAGVTVQDVMRELEKRRK Thermotoga maritima NYSGXRC-6206e SGX Pharmaceuticals 2004-07-06 active Selected EC1659 MSFIDSLSPQNVIPVEEIRYDERGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWFWSRSRQEFWHKGGTSG HTQKVQSIRYDCDSDALLVGVEQIGDIACHTGERSCFHQVEGKIVAPPGDTLSQVFQVICDRRNHPTESSYTSKL FAGGDNKILKKIGEESAEVVMACKDDDQEAIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR Nostoc sp. NYSGXRC-6207a SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC829 GENBANK NP_289338.1 MVAVRSAHINKAGEFDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTL RAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMAAIRQLKATHTDSVSSEQVDNVRRMLLAMVDDFRCVVI KLAERIAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDRE HYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYR HLPDEKDDYVANPKPNGYQSIHTVVLGPGGKTVEIQIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAW LRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPF TYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKEA EKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKPSAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEG VGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDR SGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRLHGS Escherichia coli O157:H7 NYSGXRC-6207b SGX Pharmaceuticals 2004-07-30 active Selected Cloned Expressed EC829 GENBANK NP_232080.1 MVAVRSAHLNPDQQFELETWIASLTQEGKTAAKLTAVYRDCEQLLAGNPQGPLLLWRGREMIEILITLSMDRPTLV AALLFPIATSGVLDNESLEEGYGREVVKLIHGVEEMAAIGQLNVTMHGSEASAQVDNVRRMLLAMVDDFRCVVIK LAERICNLREVKNEPDEVRRVAAKECANIYAPLANRLGIGQLKWEIEDYAFRYQQPDTYKQIAKQLSERRIVREQ YIRDFVSDLRAEMKQSGINAEVSGRPKHIYSIWRKMQKKSLAFDELFDVRAVRIIADKLQDCYAALGIVHTKYKH LPNEFDDYVANPKPNGYQSIHTVILGPEGKTIEIQIRTKQMHEESELGVAAHWKYKEGSSAARSGYDEKITWLRK LLDWQEEMSDSGEMLDELRSQVFDDRVYAFTPKGDVVDLPMGATPLDFAYHIHSEVGHRCIGAKVAGRIVPFTHK LQMGDQVEIITAKEPNPSRDWLNPSLGFVHSGRARAKINAWFRKQSREKNLEAGREILEIELAKIGANLKHAEAY ALKRFNVNSVDEMYVGIGSGDLRINQIVNHINALVNKPTAEEEDKLALEKLQENKTLTPNRPHKDAVVVEGVDNL MTHLARCCQPIPGDEIRGYITQGRGISVHRSDCEQLEELSLHAPERIIDTVWGSGFVGSYLLTVRVEAMERSGLL KDITTLLANEKVKVASMKSRSDYKRQIIIMDFDLEVNNVEALARVSKRIEQIKDVMLVKRLG Vibrio cholerae NYSGXRC-6207c SGX Pharmaceuticals 2004-07-30 active Selected Cloned EC829 MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVA CGFLHDVVEDTDITLDEIEADFGHDARDIVDGVTKLGEVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLH NMRTLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIV SKVKTYTTQQGLFGDVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFK DYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQ DASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTG DVVEIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAIL PKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQG ASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNR SGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKRTNG Streptococcus pyogenes NYSGXRC-6207d SGX Pharmaceuticals 2004-07-06 active Selected Cloned EC829 GENBANK NP_274738.1 MTAISPIQDTQSATLQELREWFDSYCAALPDNDKNLIGTAWLLAQEHYPADAATPYGEPLPDHFLGAAQMVHELDL LPDAVAATLLADIGRYVPDWNLLVSERCNSTVAELVKGVDEVQKLTHFARVDSLATPEERAQQAETMRKMLLAMV TDIRVVLIKLAMRTRTLQFLSNAPDSPEKRAVAKETLDIFAPLANRLGVWQLKWQLEDLGFRHQKPEKYREIALL LDEKRTERLEYIENFLNILRGELKKYNVHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYTT LGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEGGKGDSAY EQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAK VEGQIVPLSTPLENGQRVEIITAKEGHPSVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKLT PKPNLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSETTIVKQSKIKKGGKNGVLIDGEDG LMTTLAKCCKPAPPDDIIGFVTRERGISVHRKTCPSFQHLAEHAPEKVLDASWAALQEGQVFAVDIEIRAQDRSG LLRDVSDALARHKLNVTAVQTQSRDLEASMRFTLEVKQVNDLPRVLASLGDVKGVLSVTRL Neisseria meningitidis NYSGXRC-6207e SGX Pharmaceuticals 2004-07-30 active Selected Cloned EC829 GENBANK NP_343743.1 MVTNLPAEAKAKWLKVMDAKTPEEKFQALQEFLKEVPKHKGTENLVYWAKRRMAELREEMEVRKSKKSGGFSLFVE KEGAGQAILIGDMLLRSFIMRKLTNVKQEFNELPVPGMVKYEDVQIQLVNPPKSLPLSKTIGLIRNADEVIIAIN NKEDLSLIKSLLEDNNILLRKPKGRVVIERTRYGISGIRVVNLGKLIGIDEKVVRDYIESFGIKSAIVKIIGEVT LDDIEKSMFEAVSYKPTVVISKDRFDTGELPMLTIDQIDKLPKHLFDMLEVIRVYTKEPGEEPTKDPLILKKGST VLDVARKLHSSLAENFRYARVWGKSVKFQGQKVGPSHILEDRDIVEIHVK Sulfolobus solfataricus NYSGXRC-6208a SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble EC4805 GENBANK NP_012836.1 MMSSDQQGKCPVDEETKKLWLREHGNEAHPGATAPGNQLECSANPQDNDKTPEYHTTVDLSQSREVSTIPRTNSDR NWIYPSEKQFYEAMMKKNWDPNSDDMKVVVPLHNSINERVWNYIKSWEDKQGGEACGGIKLTNFKGDSKKLTPRA WFRSRILHLAKPFDRHDWQIDRCGKTVDYVIDFYSTDLNDANSQQQPLIYLDVRPKLNSFEGFRLRFWKSLGF Saccharomyces cerevisiae NYSGXRC-6209a SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC393 GENBANK NP_223559.1 MQSLWIYPEDTEVLGAACKSLLKALKPRYQKIALFSPISGGCEGFGECESLSSLEVHSAIDKQKALELVSTAQEEL LFETILKRYDELQSTHDFVINLGYAPKFFLNALLDLNTILAKHLNAPVVAVAQTSLDHLKAMHSHILKKEAPFAI GLFVGETLEKPHFLSASLCKQQCELEASAIENLLQTKSEIITPLAFQRSLEKKAKKQIKKVVLPESEDERILKAA HRLNLMGAVGLILLGDKEAINSQAKNLNLNLENVEIINPNTSHYREEFAKSLYELRKSKGLSEQEAERLALDKTY FATMLVHLGYAHAMVSGVNHTTAETIRPALQIIKTKPGVSLVSSVFLMCLDTQVFVFGDCAIIPNPSPKELAEIA TTSAQTAKQFNIAPKVALLSYATGNSAQGEMIDKINEALTIVQKLDPQLEIDGPLQFDASIDKGVAKKKMPNSQV AGQASVFIFPDLNAGNIAYKAVQRSAKAVAIGPILQGLNKPINDLSRGALVEDIVNTVLISAIQAQDY Helicobacter pylori NYSGXRC-6209b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC393 GENBANK NP_439359.1 MSRTIILIPVSTGVGLTSISLGLIHSLEQKGTKVAFMKPVSQPSTGEDKLDRTTSIIRTSTSLETAEPFMLSVAES LIGQNQSDVLLEKIVANHQQLTKNNDIVVVEGLIPTRKHGYANSINYEIAQALDAEIVLVAAPATETPTELKDRV EAAASLFGGKNNPNLLGVVVNKFNAPVDESGRTRPDLAEIFDSFQHNHISETEVNKLFAGSAIKLLACVPWNANL IATRAIDLVKHLGASIINEGEINRRIRGITFCARSLPNMVEHFRAGSLLVASADRPDVLVAAALAASNGIEIGGI LLTGGYKIDAQINKLCRPTFEKAKLPIFRIEGNTWQTALSLQSFNLEVPVDDKERIENIKQYISQHFNADFINNL VADSSRLPRLSPPAFRFQLTELARAAKKRIVLPEGDEPRTIKAAVLCAERGIAECVLLADPASVQRVAEAQGVKL GKGITIINPADVRENYVDRLVELRKAKGMTETAAREQLEDTVVLGTMMLEANEVDGLVSGAVHTTANTIRPPMQI IKTAPGSSIVSSIFFMLLPDQVLVYGDCAVNPDPTAEQLAEIAIQSADSAKAFGIDPKVAMISYSTGTSGSGADV EKVKEATRIAKEKRPDLLIDGPLQYDAAVMEDVARSKAPNSPVAGKATVFVFPDLNTGNTTYKAVQRSADLVSIG PMLQGMRKPVNDLSRGALVDDIVYTIALTAIQATQ Haemophilus influenzae NYSGXRC-6210a SGX Pharmaceuticals 2005-07-29 active Selected Cloned Expressed Soluble Purified EC808 ICEDB: T1869, T739 GENBANK NP_390725.1 PFAM PF00696 MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAKAISDQPSKREMDMLLATGEQV TISLLSMALQEKGYDAVSYTGWQAGIRTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRG GSDTTAVALAAALKVDKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEFAKNYQVPL EVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNINVDIIIQTQAEDK TGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSE IKVSTVVSENDMVKAVESLHDAFELSKHPSAV Bacillus subtilis NYSGXRC-6210b SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC808 PFAM PF00696 MKVVKFGGSSLASATQLEKVLNIIKSDEERRFVVVSAPGKRDAQDTKVTDALIRYYRSYTSDKDVTADQSWIINRY RAIIDELGLGQNILEKITKAIVDLANLPIEDNDFLYDTFLAAGEDNNAKLIAEYFRKNGLSARYIHPKKAGIIVT SEPGNARIIPSSYDKLEELRDSDEVLVIPGFFGVTIDNQICTFSRGGSDITGSIVAAGVKADLYENFTDVDGIFA AHPGVVHKPHSISELTYREMRELAYAGFSVLHDEALIPAYRGKIPLVIKNTNNPEHPGTKIVLAHTGATIPVVGI AGDDDFVSINLSKYLMNREIGFGRKILQVLEELNIRWEHIPTGIDDMSIILRGRELTPIKEQEIISQLTRKLEVD EVEIERNLSIIMIVGENMKNHIGVTAKAAEAFSKKHINLEMISQGSSEVSVMFVIKTEQEKQAVRALYQTFFMKD E Streptococcus mutans NYSGXRC-6210c SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC808 ICEDB: T1870 GENBANK NP_110321.1 PFAM PF00696 MRLKILIKLSGAGMSADSSEPFSNQFLETVIAQLKQLVPNYQIGIVIGGGNIMRGKSCSDYNITEIAGHHLGIMAT VINGAFLKAKFDSHKLNSTLLSAVSCPSLATHIVSQTTIDDAFKNHDIVIFAGGTGNPYFSTDTAVALRATQMQA DIILIGKNGVDGVYTADPKKDKHAKFLASLTYAEAIKNDLQIMDITAFTMCKENNLKVIIFNINAEHAIIKALSK QGKYTLIEK Mycoplasma pneumoniae NYSGXRC-6211a SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC3076 ICEDB: T1929 GENBANK NP_253606.1 MAESVFAERIVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRNAEDLRPYLAEIRYQIERLAEVEVTADQLAFL ERIPFMKPDFIRFLSLFRFNLRYVHTGIEDGQLAIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVVLEQVGEQ LYRKLDWLSAQASSEELAEFQVADFGTRRRFSYRTQEEVVHILKRDFPGRFVGTSNVHLAREYDLKPIGTMAHEW LMAHQQLGPRLVDSQQAALDCWVREYRGQLGIALTDCITMDAFLDDFDLYFAKLFDGLRHDSGDPLAWAEKAIAH YRRLGIDPLSKTLVFSDGLDMPKALQLFRALRGKINVSFGIGTNLTCDIPGVEPMNIVLKMTACNGHPVAKISDA PGKTQCRDENFVAYLRHVFNVPA Pseudomonas aeruginosa NYSGXRC-6211b SGX Pharmaceuticals 2006-10-03 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC3076 ICEDB: T1871 PDB 2IM5 GENBANK NP_904408.1 PFAM PF04095 MGIIRSILDTDLYKFTTGYAYAKLFPRAYGEFRFIDRNRQGFTEEFAELVRGEIRAMAALSLTRDEKEFLQRELPY LPPIYIDFLDGFRFDPEEVTVSIDAQGHLDIRAQGLLYRVTLWETPILAVISELYYRFIGAEPDWKQVEEVTRSK GELMREHRATFSIFGMRRRFSLEVEDRVTDILKQYAGESLFGTSNVHLAHKHGLRVSGTHPHEWIQFHGAIYGYK MANYVAMEDWINVYDGDLGTVLTDTYTTDVFMRNFSKKHAMLFTSLRHDSGDPEIFIEKAVRRYEELRVDPKIKY IIFSDSLTPQRAIEIQKLCAGRIKASFGIGTNLTNDVGGGVEPLNIVMKLWKCKMTAKDDWHYCVKLSDVDGKHT GEPEEILLAMNTLGIKPK Porphyromonas gingivalis NYSGXRC-6211c SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3076 MPCPSRRPEQTRAARWYLAWRALTQQPWPQDTQRTVAASRYRGGVNDWVPTGRRCGPRRTAVGPPPAARRREGEPD NQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFL DPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPL IEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRG EPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVI VEPHRVLTLPLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA Mycobacterium tuberculosis NYSGXRC-6211d SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC3076 MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSG LPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGSWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALE SKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAH QQINPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKL GIDPLTKTLVFSDNLDLPKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKT ICHDKAFVRALRKAFDLPQVRKAS Salmonella typhi NYSGXRC-6211e SGX Pharmaceuticals 2004-07-06 active Selected Cloned EC3076 MEFIIKSLLDTDLYKFTMMQAVLHQYPGAQVEYRFKCRTPGVDLARFINEISHEIDGLCALRFSKEELDYLRGLRF MKPDFVDFLGLFHLDRKYLQLRASTQVSGEIELDIRGPWLHTILFEVPLLAIINEVWFRNTSMLNLDVGRARLDA KVRLLKGESGYEECSIADYGTRRRYSRQWHAELLPLLAQGLGSNFVGTSNVYFAKQYGYTPLGTMAHEYLQAFQA LGPRLRDSQVAGLEAWAREYRGDLGIALSDVVGLDAFLGDFDLYFCKLFDGMRHDSGDPFKWGERIIMHLESHRI DPRTKVLVFSDGLDMNKVMRLYQHFRGRCRLAFGVGTSLTNDLGPTPLQIVIKMVRCNGQPVAKLSDSPGKSMCD DPAYLHYLRQVFGVSADV Xylella fastidiosa NYSGXRC-6211f SGX Pharmaceuticals 2004-07-06 active Selected Cloned EC3076 GENBANK NP_274513.1 MTGIIHSLLDTDLYKFTMLQVVLHQFPQTHSLYEFRCRNASTVYPLADIREDLEAELDALCQLRFTHDELGYLRSL RFIKSDFVDYLELFQLQRRFVEIGTDDKDRLNIRIEGPMIQAMFFEIFILAIVNELYFRRLETPAVIEEGERRLQ AKAARLKEIAAAQNPDEPPFLISDFGTRRRYKLAWQEHVIRTLLEAAPGIVRGTSNVFLAKKLGITPIGTMAHEF LQAFQALDVRLRNFQKAALESWVHEYRGDLGVALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYVWGDKAYAH YQKLKIDSRTKMLTFSDGLDIERSWALHQYFKDRFKTGFGIGTNLTNDMGHTPLNIVLKLVECNGQSVAKLSDSP GKTMTNNSTFLAYLRQVFDVPEPETP Neisseria meningitidis NYSGXRC-6212a SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1872 GENBANK NP_215574.1 MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDVGQRAGQLANALRRLGVTGDQRVATFMWNNTEH LVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREA GKTVLRFAELIDAESPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDKVLPI VPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEKDPDHDMSSLRLVA CGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAWPPPGTPDDQHWAFRITQGQPVCGVETRIVDDDGQVL PNDGNAVGEVEVRGPWIAGSYYGGRDESKFDSGWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCL IAHPDVLEAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKA IRSRYAEGAYQITEVHT Mycobacterium tuberculosis NYSGXRC-6212b SGX Pharmaceuticals 2004-06-29 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1873 GENBANK NP_242798.1 MMNSPLLLSHFIERAERYFPTKQVISRTLNGKKSLTYQQIGERTRRLASALAQFGIKKGDRVGTFAWNTHRHLEAY FAIPGIGAVLHTINLRLSQDHIAYVINHAEDRVLFVDADVWPLIAQLRDQLSSVEAFVLMSDGELPEVDWPNVFS YEEFIAKGDPSFEFVQSIDETSPAGICYTSATTGKPKGVVYSHRGIYLHSMALGLADTAGLSEKDVLMPVVPMFH VNAWGLPFAATWFGTTQVMPGPQFTPQVLAELIDEEKVTLAAGVPTIWLGLLRELETGVYQTEHLRAILCGGSAA PAAMIQTFEQKYNVPFLHAYGMTETSPLVTVSMVKSYQADLNEEETLELRAKQGLVVPGLEVKVVGPNGEVKPDG AEMGELLIRGPWIADHYYKAEEVSDAFADGWLHTGDVATIDEEGFIKLVDRTKDLIKSGGEWISSVDLENAIMAH EDVFEAAVVSVPDPKWQERPVACVVLKDPNKGSVAEADIRRFLEGKFPSWWLPDRVIFMDELPKTSVGKFLKRAL REQVKEQMEANR Bacillus halodurans NYSGXRC-6212c SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1874 GENBANK NP_111828.1 MNGDYQLTIDKMLESGVSSNPNQIINYSGKKTFTYKEFRERVYRLAKALISIGVKKGDTVAVIDWDTYVYLEAYFA VPMIGAVLHTVNVRYPQDLIYYTMDHAEDKYVIVRDEFVPILSKNKEAFYFIKGWIIYSEYGNVPDELSPKYIYD ELMSKNYDIELPEISENDLATTFYTSGTTGIPKGVQFTHRQIVLHAISSGLALSDRPISLTADDVIMPLVPMFHV HAWGVPYMTIMSGRQYVLPGRYDFDHIIDLIAQENITVIAMVPSILYMIVTNPNVGKIAGRKIRAIIGGGALPEG LQKAAEKLGIMAISGYGLSETAPILTLATYNSDVKKLPLEEQKKYHLKTGIPIPLVQLRVIDDKWNDVPRDEKTI GEIVVRAPWLTSVYVKNKEGTEALWKGGWMHTGDLAVMDKFGYIKIVDREKDAVKSGGEFIPSLILEDAISACPG VVENAVVGKPHEKWGERPVAFYTGTAKPEEIRKCLEDIVRQGRIAKFWIPDDFINVKEFVKTSTGKIDKKVLREM LKK Thermoplasma volcanium NYSGXRC-6212d SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2046 MSNLVTNVQTSATELPDHPAVVYDDHTHTYSDLWERTGQFAAALRDHGVTPDDRVALYLPNLPQYVTAFHGALRAG CVVVPMNPQYKTREIEYLLSDSGASVVVALADGASTVEDVRAETAVDTVVTVGGDADVGTPFEAFLDTGSDDTVA PRDDDDLAVQPYTSGTTGQPKGVQLTHHNLASNAEQSMDIVPDGLQPADRKIGVLPLFHIYGMTVGMNAALFAGA TFYPMPRWDTEDAMSLVADAELTLFDGVPTMYNDIITHPNAEEFDLSSVRRCTVGGSGIPTEVLRKFEELYTAKI DEGYGLTETSPVTHFNSPNWGRRVGSIGKPLAGIDARIVTDDFESVPPVDEGPVDESDHDMDDITGELVVSGPNV MAGYLDLPEANRKAFTEADGKRWFHTGDLGYHDADGYFYIVDRKTHMINTAGYNVYPREVEELLFEHDAIADAAV VGVPDERRGETVKAYVVRAPDTDVSADEIREFCLTNLAEYKHPRTVEFVEQLPRTTTGKIKKHELVPDED Halobacterium sp. NRC-1 NYSGXRC-6212e SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed Soluble Purified EC2046 GENBANK NP_069100.1 MRFVRGFPSTMMDEYQLNITNILRHAATNFPEREVVSRNLDGSLFRYSYGEAYERVSRLANVLEELGVDVGDRVGV LSWNTHRFFELFFAIPGIGAVLLEMNLRLHPREIAYVANHSGAKVIFVDESLLPIAEAIAPSIGVEKYVVMTDGE TPETKLPEVYSYEELLRKASKDYDFPMVDETSAYAACYTSGTTGNPKGVYYSHRSMVLHSLIAAIGMGLRPEDAY MQLVPMFHANGWGVFFAATLAGSKLVFPGRYAVDNLAPVVELMQSEKVTATAGAPAIFLPMLNYLQKVEPKPKFN IRAWSGATEPPLAVMKGLKEFGIEIIHAYGATETSPLVCYNYVKPELREKLNEEELWELKRKQGIPVFGVEVMLV DEEGNRLPHDGKTIGELCIRGHWITGSYYKDARTFESFIDDGLLKWWKSGDAATIDEWGYIKIVDRFKDLIKSGG EWISSVDLENHLMAHPKVFEACVVGIPHPKWEERPLAFVVPKPEFKDSITKEELYEHLKQRFAKWQLPDDIIITD EIPKTSVGKFSKRTLREQYKDYYTK Archaeoglobus fulgidus NYSGXRC-6212f SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2046 VALTAASISESLCSRCLHVSGPGGFPMRSNMMPVPLTIPFILERARTGFAEREIVSLLPAGKDAQGQPIAQTHRTT YGEVADRALRLGAGLQALGLQPGDRVATLAVNSFRHLEAYLGVPSAGFVLHTVNIRLHPEQVAWILNHAEDRVLL IENVFAAMIPAIRAACPKLEHVFVLGGLPQPIPGVADYDQWVMSQEPLTHYPQLDENDAAAMCYTSGTTGNPKGV LYSHRSTVLHSLASAPKDALNVGEADSVLPIVPMFHVNAWGLPYTCAMYGAKQVFSGVFTDGKSIAQLMQDEGVT STAGVPTIWMGLLSELDRAKQAGEPYDLSGLERLIVGGSAAPESLIRAFEERHNLRLLHAWGMTETHPLGTASTL PLNMDPRSDEGYALRAKQGRPVPLVELEIVDDDSNVLPHDGAAMGRLLCRGPWIADSYFKGEGASSFLTLDGNLW FDTGDIATLDERGYMHIQDRSKDLIKSGGEWIGSVELENAIMAHPAVAQCAVIAMDDPKWDERPLAVVVLRPGQA ATHEELTEFIAPKFAKWWLPDATVFTDALPIGATGKFLKRELREEYRGYRQQNFPQRQD Deinococcus radiodurans NYSGXRC-6212g SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC2046 MDIVGGQNLRQMWDDLAGMYGDKTALIFESCEGIVRQFSYASLNEEINRTANLFYYLGIRKGDRVALHLDNCPEFI FCWFGLAKIGAIMVPINARLLGEESAWILQNSQVSLLVTSAQFYPMYREIRQDNSTPLNHICLIGEQLPADDGVS HFSQLQARQSATLCYTPALSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQIALRDDDVYMTVMPAFHI DCQCTAAMPAFSAGSTFVLLEKYSARAFWDQVRKYQATVTECIPMMIRTLMVQPATPTDRQHHLREVMFYLNLSA QEKDAFTERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFSYEAEIRDDQNRPLPAGEIGEICIKGIPG KTIFKEYYMQPEATARALEPEGWLHTGDSGYQDEDGYFYFVDRRCNMIKRGGENVSCVELENIISAHPKIQDIVV VGIKDAIRDEAIKAFIVLNEGETLSEAEFFSFCENNMAKFKVPSFMEIRTDLPRNCSGKIIKKNLK Salmonella typhi NYSGXRC-6212h SGX Pharmaceuticals 2004-07-26 active Selected Cloned Expressed Soluble Purified EC2046 GENBANK NP_393772.1 MEYKYELTIDKLLQSGVSSNPDQIINYTGKREFTFKDFSKRVNTLAKALISIGVKKGDRVAVIDWDTYVYLEAYFA VPMVDAVLHTVNVRYPQDLIYYTMDHAEDKYVIVRDEFVPILSKNREAFYFIKGWIVYSETGQIPDSLSPKYVYD DLMKESYSDIELPQLSENDLATTFYTSGTTGIPKGVQFTHRQIVLHSISSGLALADDPINLTSRDVIMPLVPMFH VHAWGVPYMSIMSGRRYVLPGRYDFDHIIDLIDKYNVSVIAMVPSILYLIVTNPNVKKIAGRGIKAIVGGGALPE GLANAAEKLGITAISGYGLSETAPILTLATYNERVKAMPESEKKKFRLKTGIPIPLVQLRVVDDKMNDVPKDEKT IGEIVVRAPWLTSVYVKNKEGTEALWRGDWMHTGDLAVMDEYGYIRIVDREKDAVKSGGEFIPSLVLEDAISSCS GVVENAVVGRPDEKWGERPVAFYTGTAKPDEIRKHLIEMVNAGRIAKFWIPDDFINIKEFAKTSTGKIDKKVLRE MIKK Thermoplasma acidophilum NYSGXRC-6212i SGX Pharmaceuticals 2004-07-21 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1930 GENBANK NP_288135.1 MHPTGPHLGPDVLFRESKMKVTLTFNEQRRAAYRQQGLWGDASLADYWQQTARAMPDKIAVVDNHGASYTYSALDH AASCLANWMLAKGIESGDRIAFQLPGWCEFTVIYLACLKIGAVSVPLLPSWREAELVWVLNKCQAKMFFTPTLFK QTRPVDLILPLQNQLPQLQQIVGVDKLAPATSSLSLSQIIADNTPLTTAITTHGDELAAVLFTSGTEGLPKGVML THNNILASERAYCARLNLTWQDVFMMPAPLGHATGFLHGVTAPFLIGARSVLLDIFTPDACLALLEQQRCSCMLG ATPFVYDLLNLLEKQPADLSALRFFLCGGTTIPKKVARECQQRGIKLLSVYGSTESSPHAVVNLDDPLSRFMHTD GYAAAGVEIKVVDDARKTLPPGCEGEEASRGPNVFMGYFDEPELTARALDEEGWYYSGDLCRMDEAGYIKITGRK KDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGERSCAYVVLKAPHHSLSLEEVVAFFSRKRVAKYKY PEHIVVIEKLPRTASGKIQKFLLRKDIMRRLTQDVCEEIE Escherichia coli O157:H7 NYSGXRC-6212j SGX Pharmaceuticals 2004-06-23 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1875 GENBANK NP_388908.1 MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQEAGMEKGDHLALLLGNSPDFIIAFFGALKAGI VVVPINPLYTPTEIGYMLTNGDVKAIVGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAK ILRPTSAAKQNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPMCHVFCLTV CMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHENGKKDDFSSIRLCISGGASMPVALLT AFEEKFGVTILEGYGLSEASPVTCFNPFDRGRKPGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGY YKMPMETEHALKDGWLYTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQS GEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALRDILPQ Bacillus subtilis NYSGXRC-6212k SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC2046 GENBANK NP_355840.1 MTMQSAVQHPAGGVAPSTTRVMNLSHFLTQAARRNPDHIGFVWGEKTWSWAQMEARVDAMAHALETEFGVRKGDRI LVQSSNNNQMFESMFACFRVGAVWVPTNYRQSPDEVAYLAKASGARGMICASAFPDHAKASHEASTIDFSIAIGT AEFGEDYDAIVARHMGRKVKSQAVDRDDPCWFFFTSGTTGRPKAAVLTHGQMAFVITNHLCDLMPGTGPDDASIV VAPLSHGAGIHQLVQVAHGAKTVLPAAEKLDVPAVWALIEKWRITNAFTVPTILKMLVEDPSVDRFDHSSLRYVI YAGAPMYRADQKRALAKLGPVLVQYFGLGEVTGNITVLPPSFHNAEDGPETRVGTCGFDRTGMEVQIQNDAAEEV GAGETGEICVIGPAVFAGYYDNPEANAKAFRNGWFRTGDLGHRDENGFLYITGRASDMYISGGSNIYPREIEEKI LMHPDISETAVLGVPDAVWGEVGVAVCVAREGADIAAIDLKAYLEGKMARYKLPKSVVFWDAMPKSAYGKITKKM IREELEKRGQMPAFEEKRTG Agrobacterium tumefaciens NYSGXRC-6212l SGX Pharmaceuticals 2004-07-23 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1931 GENBANK NP_370758.1 MNFDWIKTRSDFDDDKPAVIDHAKQTSWTYQQLNARADNMAHYLTSQGVKKGDVIGIFAPNDIAILDLLFACFKTG AVFLPLNWRLNPKEIAAIVEDAQLKLLFYAEKHLSSLTDIDQNLLHMDIDVAQYDEIVNPDYHQPFQATPVEPQD LAALIYTSGTTGSPKGVMFSYESFVHNGANLELTYKFNSNYITIVSTPMFHVLGFNDTVLPVLMSGGTLILQRYF NGEELNDMIAQYHPTFIIMIPTMYYSTLRASNFNPENFRAMDYIIQGGSQPLPSIQAAFKQYGINIINGYGLTEA PLVLVNTPENSKRKPMSIGKAVMFVDARILDDNGEEVPTGEIGELAIKAKNVTPGYWNKPAETAKAFHGRYLLTG DLAKMDDDGDIFIIDRKKELIITGGENVLPSEVENALAEHPLVDRCVVVGYDHPKYGESIAAAIILREDEPHYAE ILDQHMRSRLAGYKVPRMYVPVTHMPLNSTQKPDKLAIRQMMNDKVSQTL Staphylococcus aureus NYSGXRC-6212m SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC2046 ICEDB: T1932 GENBANK NP_252887.1 MSIFEQGLAPAAVNHIALTPLSFIERTASVYPHYPAVIHGNIRRDWAQTYQRCRRLASALAGRGIGQGDTVAVMLP NIPEMLEAHYGVPMIGAVLNTLNVRLDAEAIAFMLQHGEAKVLITDYEFHEVIHAAIGMLDHPPLVVDVNDPEYG EGRPVGELDYEALLAEGDPQFAWEWPRDEWQAISLNYTSGTTGNPKGVVYHHRGAYLNALGNQMTWSMGQHPVYL WTLPMFHCNGWCYPWTVTALAGVHVCLRRVDPQKVLTLIREHQVSHLCGAPIVLNALINMPDSAKAAIDHPVHAM VAGAAPPAKVIGAVEEMGIRVTHVYGLTEVYGPVTVCAWHGEWDDLPLERRAAIKSRQGVRYPTLEGVMVADPKT LEPVPRDGQSIGEIFMRGNTVMKGYLKNPSATEEAFAGGWFHTGDLAVCHPDGYIEIRDRLKDIIISGGENISTI ELEGVLYRHPAVLEAAVVARPDEKWGETPCAFITLKSDHQGLAESEIVAFCREHLAAFKIPRTVVFSELPKTSTG KIQKYVLREWAAAL Pseudomonas aeruginosa NYSGXRC-6212n SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2046 VKEFLALPEKTPWRPGYSLTIHKIYQYALYMWSDLEIVSRTTKGLERYTFSDAARRIESLANALRALGVSGLDRVA TMDWNTHWHYETYFAAPMMGAVLHPLNVRLAPNEIAYIMNHAEDKVLIVHSDFLKLAEAILPHAPSVEHVVIVDA ESHPDRIAGRRLHNYEDLIKEHGGRFEWPELDENRPAAMGYTSGTTGLPKGVYHSHRMIVVHALSGALALATRGR RRVTGDDTLLHIVPMFHVLAWGLPYMATLTGMKQVFPGRLDPKVLLDLIVGEKVTVTAGVPTILYMLLSHPESGK YDLSGLLFVNGGQALPKGLADAARKRGIEVIVGYGMTETAPILTLANVPQKYMDRSEELSLTTGWPVPLVELMVA DPETLEPVPKDGKTMGEIVVRTPWVTPEYYKDPEKTEKAWRGGWFHTGDIAVWTPEGYIQIVDRDKDIIKSGGEW ISSLRLESLISQHPGVAQVAVIGARHPKWGERPVAIIVPKPGWQDKLTTEEVREWLAKNFVEKGEIPKWWLPDKI VLVDDLPKTSVGKINKRSLREKFANILEQEPQQ Aeropyrum pernix NYSGXRC-6212o SGX Pharmaceuticals 2004-07-06 active Selected EC2046 MSFTTLYSAIQGDASARALVAPSLNAELSFSELRIAIMDLQRQIASLGIKVGDPVNIAIPNGLEFVVAFYAVSWQR AICGPLNSNYKQSEFEFYIDDLKSKLVIVPEGSVAANTPAVRAAKKLSVAVAELAWCPKSRLVRIVHFEGAKINA PQPLGLPQPDDVMLVLHTSGTTGRPKVVPLTHKNLCRSIHNITTSYRLDPRDTSYVVMPLFHVHGLLCGLLSTLA SGGCAVVPPKFSAHSFWKEFIQYGATWYTAVPTIHQILLRTPPPKPLPRIRFIRSCSSPLAPPVLSKLEATFRAP VLEAYAMTEASHQMTTNPLPPLVHKPHSVGKPFGVELKILDQKGNEMPQGKEGEICVRGINVTKGYLNNPAANKS SFTKDRFFRTGDEGKLDKDGYVFITGRIKELVNRGGEKISPAEIDAVLMQHPDVSEAVCFAVPDEKYGQDIQAAI NPVAGKTVTPKQLHDYLEQKVAAFKIPKKFYFTDRIPKTATGKVQRRLVCDAFFNHSKAKL Schizosaccharomyces pombe NYSGXRC-6212p SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC2046 MGHMMSAPLLISTIIEHAARNYGSTEVVSRRVEGDGGELHRTTYAAVRDRAKQLANALAALGVQPGERIGTLAWNG YRHLEIYYGVSGSGAVCHTINPRLFPDQVAYIVNHADDQYVFFDLTFVPLVEGLAPHCPNVKGWVAMTDRAHMPA SSVPMLCYEDLLAAQRAEYTWPLFDENTASSLCYTSGTTGNPKGALYSHRSTVLHSYGSALPDALGCSAQDVILP VVPMFHVNAWGLPYSVPLVGAKLVFPGPKLDGASLYELFEQEQVSFSAGVPTVWLGLLQHVQGKGLKFSSFRRTV IGGSACPPAMIRTLNALGVEVIHAWGMTEMSPLGTTCKLMSKHNGLPDETRQQVLERQGRAIYGVEMKIVDGNGH ELPWDGKAFGDLHVRGPWTIASYYRNGQSPLVDGWFPTGDVANIDPDGYMQITDRSKDVIKSGGEWISSIDVENV AAAHPAVHMAACIACRHPKWDERPLLVVMKKPGAELTRDEMLRYFEGKVAKWWIPDDVVFVTEIPLTATGKMQKL KLREQFRDYQLPLAQA Ralstonia solanacearum NYSGXRC-6213a SGX Pharmaceuticals 2004-07-27 active Selected Cloned EC2535 MPRYPFRRFGFGALRRLLYLWVRSETINQSAFTLKIDRSKPVLYVLQQPSVSDLAVVDTECRKAGLPRPVMPVAVG DAIEPAAFFYLTPEPDWLGRQDKRGASPTLVRMLAAVGQNGLDDAQIIPVSVFWGQSPDSESSPWKLLFADNWAV TGRLRKLARILILGRKTRVQFSAPIHLRELVEQGKGHERTLRMVNRILRVHFRNLKTAVIGPDLSHRRNLVKGLL RAPLVRQAISEECESERISQEKAEGIALRYANEIASDFSYPVIRFLEVILSWFWNKLYEGVKVNHIERVQDVAQG NEIVYVPCHRSHIDYLLLSYLLFRNGLTPPHIAAGINLNMPVIGSILRRGGAFFMRRSFKGNQLYTAVFNEYLHT LFSRGFSTEYFVEGGRSRTGRMLHPRTGMLAITLRSFLRDSRRPIVFVPVYIGYERVLEGRTYLGELRGATKKKE SIFDLFKVVGALKQRFGQVWVNFGEPIHLDQFLDRHQPDWQDQDLGPEYRPDWLPQTTNLLAKDVARHLNDAAAI NPVNLVALALLSTSRQALDESALARILDLYLALLRKVPYSPSATLPDGDGQALIEYVKSMNLLAEQKDALGRILY LDEQNAVLATYYRNNVLHVFALPALIASFFQSNSRISREQLLRFARALYPYLQAELFIRWSLDELDAVIDQWLAA LVEQDLLRQENDTFIRPAPSSRQYVLLILLARSVTQTLQRFYMAIALLLNAGQNALTAEELENLCTVMAQRLSIL HGLNAPEFFDKSLFRHFIQTLLDLRVLRKDEAGKLSYHELLGELAEGAAKRVLPAEIRLSIRQVALERPAEEAAA ESNDAAAN Pseudomonas aeruginosa NYSGXRC-6213b SGX Pharmaceuticals 2004-07-06 active Selected Cloned EC2535 LNSMSSGHLLSRSLLKLPMSVLVKGTAIPSNPIQDLDIDTHKPVIYALPFRSNVDLLTLQTHAKEAGLPDPLEPLM LNGKAFQRYVFIASRPTLLSSDQHVPSDSIALFSELLTEHKLDSELDVQVIPATVLWGRKPGKEGQERPYLQALN GPEKALAVLASGRDCLVRFSPVVSMRYMADTHGTDASIAHKLARVARIHFSRQKLAASGPNLPQRAQLFARLMNS PAIEKAIADEAKSKQIPLEKARKEAHDILDEIAADFSYSLVKKGDRILGWLWNRIYQGLNINNAATVRRLAQDGH EIVYVPCHRSHMDYLLLSYVLYHEGMVPPHIAAGINLNFFPAGPIFRRGGAFFIRRSFKGAPLYSTIFREYLAEL FAKGYSVEYFSEGGRSRTGRLLPAKTGMLAMTIQAMLRGLNRPVTLVPVYIGYEHVMEVGTYAKELRGKRKEKEN AGLVLRTLRKLRNFGQGYVNFGEPIPLNQFLNETVPQWTQDIDPMGESKPQWMTPTVNKLANRMMTHINDAAAVN AMTLCATALLASRQRALARDNLIKQVDCYLSLLRNVPYSATSTLPSESAEKLVEHAESLDKFVVETDTMGDIISL DRNQSILMTYYRNNIIHLLALPSLIAQLLIRQQSVSLEKVQATVAQIYPFLKQELFLRFEAEELNDLVLRYVAEL ARQGLVTVEGKTVTLNQAQTQVLMLLGRIISETLQRYAIALNLLVSCPHLGKAELEEKSQEVAQRLGRLHGINAP EFFDKGVFASLFVTLQEQGYLDDQGRCVLETAKPLSRQLYALIYPEVRMTIQESLCQVDA Vibrio cholerae NYSGXRC-6213c SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified EC2535 GENBANK NP_438907.1 MANFINMYRQLLSLPLSALVKNNPIPANPIEELSLNIHQPIVYVLPYTSQTDFVIFRRNCLALGLPDPAEKNEING VKLPRYVYLDEGRRIFKSKGAKDETTTIFNKYLELHRTSESLDVQLIPVSVLWGRSPGQEDKSDLPNLRLLNGIQ KTFAAIWFGRDTFVRFSQAVSLRYMVVEHGSDEKIAQKLARVAKMHFAKQRISATGPRLPNRQAMFNKLLQSEAI RRAIEDEAKSKNISIEKAQKEAYKILDEIAADVSHSSLRAVDRFLRWLWNKLYSGINVQNSNRVRKLALEGHEIV YVPCHRSHIDYLLLSYVLYHQGLVPPHIAAGINLNFWPIGRMFRSWGAFFIRRTFKGNRLYSAIFREYLSELFHR GYSVEYFIEGGRSRTGRLLAPKTGMMSMTLQALQHSQTRPISIVPVYVGYEHVLEVDTYAKELRGAAKEKENAGL VLRVIKKLRNLGQGFVNFGEPITLSNYLSQHFPDWKEQNHEEKPQWFTPAVNNISKQVMININKAAAVNSMNLVG TALLSSRQRALSREQLLEQLSSYQQLLQNVPYSTDVVLPNVTPQAMLEHVLALDRIGVLIEKDNFGEIVRLERSS AVLMTYYRNNIQHLFVLPSLVASIILHYEAIQKDLLLDAIRKIYPFLQGELFLHFNEDELNVQIHQIINEFARQS VINSNDNFLSINKSKVRILQLWSAGMLEILQRYYITVTILQKQPAISRAELEKESQLVAQRLSVLHGINAPEFFD KAVFSSFIANLKEQRYFDESGYTVLDKIEELASTLSHLISTEICLTVKGTIEKSEDLSS Haemophilus influenzae NYSGXRC-6214a SGX Pharmaceuticals 2004-12-01 active Selected Cloned Expressed Soluble Purified EC1024 GENBANK NP_290230.1 LYLFESLNQLIQTYLPEDQIKRLRQAYLVARDAHEGQTRSSGEPYITHPVAVACILAEMKLDYETLMAALLHDVIE DTPATYQDMEQLFGKSVAELVEGVSKLDKLKFRDKKEAQAENFRKMIMAMVQDIRVILIKLADRTHNMRTLGSLR PDKRRRIARETLEIYSPLAHRLGIHHIKTELEELGFEALYPNRYRVIKEVVKAARGNRKEMIQKILSEIEGRLQE AGIPCRVSGREKHLYSIYCKMVLKEQRFHSIMDIYAFRVIVNDSDTCYRVLGQMHSLYKPRPGRVKDYIAIPKAN GYQSLHTSMIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEHGETSTTAQIRAQRWMQSLLELQQSAGSSFEFI ESVKSDLFPDEIYVFTPEGRIVELPAGATPVDFAYAVHTDIGHACVGARVDRQPYPLSQPLTSGQTVEIITAPGA RPNAAWLNFVVSSKARAKIRQLLKNLKRDDSVSLGRRLLNHALGGSRKLNEIPQENIQRELDRMKLATLDDLLAE IGLGNAMSVVVAKNLQHGDASIPPATQSHGHLPIKGADGVLITFAKCCRPIPGDPIIAHVSPGKGLVIHHESCRN IRGYQKEPEKFMAVEWDKETAQEFITEIKVEMFNHQGALANLTAAINTTTSNIQSLNTEEKDGRVYSAFIRLTAR DRVHLANIMRKIRVMPDVIKVTRNRN Escherichia coli NYSGXRC-6214b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1024 UNIPROT P43811 VIARDAHEGQFRSSGEPYITHPVAVASIIAQLHLDHEAVMAALLHDVIEDTPYTEEQLKEEFGASVAEIVDGVSKL DKLKFRTRQEAQVENFRKMILAMTRDIRVVLIKLADRTHNMRTLGSLRPDKRRRIAKETLEIYCPLAHRLGIEHI KNELEDLSFQAMHPHRYEVLKKLVDVARSNRQDLIERISQEIKVRLENSGIFARVWGREKHLYKIYQKMRIKDQE FHSIMDIYAFRVIVKNVDDCYRVLGQMHNLYKPRPGRVKDYIAVPKANGYQSLQTSMIGPKGVPVEVHIHTEDME QVAEMGITAHWVYKENGKNDSTTAQIRVQRWLQSLVEIQQSVGNSFEFIENVKSEFFPKEIYVFTPKGRIVELPM GATAVDFAYAVHSDVGNTCVGVTVEHKPYPLSKALESGQTVNIITDPNAHPEVAWLNFVVTARAKTRIRHYLKQR CEEDAVKLGEVELNVALQPHNLGDFSIQQIRTVLDALALSSLDELLREIGLGNQSASMIAHQFVGVPLESANTKN LEFESKILTIAPMQVGKTQFAQCCHPILGDPIVGCCTEKNTVVVHHQHCASLKNACRQSLAKWDNVQSAVNFEAE LQIEILNEQNALLSLMTAISASESSLQNIWTEELENNLLLVILQVCVKDIKHLANIVHRIKGITGVVNVKRNINE L Haemophilus influenzae NYSGXRC-6215a SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC965 ICEDB: T1876 GENBANK NP_216105.1 VTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAVLQLPDDRLEELLALAHEVRMRWCGPEVEVEG IISLKTGGCPEDCHFCSQSGLFASPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAAGIEAI RNEVEINIACSLGMLTAEQVDQLAARGVHRYNHNLETARSFFANVVTTHTWEERWQTLSMVRDAGMEVCCGGILG MGETLQQRAEFAAELAELGPDEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFRLALPRTMLRFAGGREITLGD LGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQMPLKALNASL Mycobacterium tuberculosis NYSGXRC-6215b SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble Purified EC965 ICEDB: T1877 GENBANK NP_242614.1 MNWIQLAQEVIEGKRISENEALAILNSPDDELLLLLQGAFTIRQTYYGKKVKLNMIMNAKSGFCPENCGYCSQSSI SKAPIDAYPMVNKETILEGAKRAHELNVGTYCIVASGRGPTNRDIDHVTEAVREIKDTYGLKICACLGILKPEQA EQLKAAGVDRYNHNVNTSARHHDQITTSHTYEDRVNTVEVVKHSGISPCSGVIVGMKETKEDVVDMAFQLRELDA DSIPVNFLHAIDGTPLQGVHELTPIYCLKVLSLFRYVCPTKEIRISGGREVNLKSLQPLGLYAANSIFIGDYLTT AGQEETADHQILKDLGFEVESVEEMKASLQGQ Bacillus halodurans NYSGXRC-6215c SGX Pharmaceuticals 2004-06-29 active Selected Cloned Expressed Soluble Purified EC965 GENBANK NP_213667.1 MDKVERRLYELYEKAINYEPLSKEEALYILEVDDIYVPFLVHLAQKIKKHYFPENEVEFCSIINAKSGACSEDCKF CAQSKYYKTPINVYNLVPVDEMVEGAIRGVEFGANRYCIVLSGKSATKEEVERITEAVKEIKNEGLPINVCVSAG TLDEESLKKLKEAGVKRINHNLETSRNFFKNIVTTHTWEDRYETIKRIKKVGLSTCSGGIFGMGESNEDRVDMAL TYRELEVDSIPLNFLMPIEGTPMENAPGVEVMEALKIIAMFRFTNPKAELRLCGGREQNLRDFHGMATLMTNAMM VGGYLTRAGRDIKKDYQLLKDLKAKRKVSVE Aquifex aeolicus NYSGXRC-6216a SGX Pharmaceuticals 2004-07-01 active Selected Cloned Expressed Soluble Purified EC747 ICEDB: T1892 GENBANK NP_418037.1 MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRALLTHSGVSGEQIVGI GISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYA QIGCVMMTHDYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTA ALTGLKAGTPVVGGLFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEAS PTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGV VFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYHNFSEA QRDLRHPVRTLLPDMTAHQLYQKKYQRYQHLIAALQGFHARIKEHTL Escherichia coli NYSGXRC-6216b SGX Pharmaceuticals 2004-07-01 active Selected Cloned Expressed Soluble Purified EC747 ICEDB: T1893 GENBANK NP_349219.1 VRYLLGIDVGTSGTKTALFDECGNTIKTSTHEYELFQPQVGWAEQNPENWWTACVKGIREVIEKSKIDPLDIKGIG ISGQMHGLVLIDKEYKVIRNSIIWCDQRTEKECTQITDTIGKEKLIRITGNPALTGFTLSKLLWVRNNEPDNYKR IYKVLLPKDYIRFKLTGVFAAEVSDASGTQMLDINTRNWSEELLDDLRIDKNILPDVYESVVVSGCVIEKASKET KLAVNTPVVGGAGDQAAGAIGNGIVREGLISTVIGTSGVVFAATDTPRFDSKGRVHTLCHAVPNKWHIMGVTQGA GLSLNWFKRTFCAKEILESKEAGINIYDLLTEKASQSKPGSNGIIYLPYLMGERTPHIDPNVKGAFLGISLINNH NDFVRSILEGVGFSLKNCLDIIENMKVNIEEIRVSGGGAESSIWRQILSDIFNYELTTVKASEGPALGVAILAGV GAGIYNSVEEACDKIVKGNEKVMPNANLIEVYSKVYEVYNSAYPKIKDI Clostridium acetobutylicum NYSGXRC-6216c SGX Pharmaceuticals 2004-06-25 active Selected Cloned Expressed Soluble Purified EC747 ICEDB: T1894 GENBANK NP_389643.1 MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSEQNPEDWVQQTIEALAELVSISNVQAKDIDGIS YSGQMHGLVLLDQDRQVLRNAILWNDTRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKT AVFLLPKDYVRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLLPHVAAKTG LLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDFKGKVHFFNHGKKDSFYTMGVTLAAG YSLDWFKRTFAPNESFEQLLQGVEAIPIGANGLLYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGI TFSLHESIELFREAGKSVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEEC AEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN Bacillus subtilis NYSGXRC-6216d SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC747 MNLYVGLDVGTTGVKGILVNEKGEILATANERLTMFTPQPAWAEQDPLSWWEAVKKILKNLSERSKEMGGKIRAIS TSGQMHSLVAIDDNGKVLRNAILWCDQRTYKECEEATQILGGEENVLKLVGNPILPGFTLPKILWIRKHEPEIYG KISKIMLPKDFINYMLTGEVKTEHSDASGTVMYSVSKMEWNKDVLKELNIPESVLPEIIPSNGVVGNVKPEVASD LGLSEDTLVIGGGADNACAALGIAVVEPGDVMVSLGTSGTVLAPTKGNQPDPKGRVHFFAHTVPETRYHMGVMLS ATYSLEWFKEKFLSEDYETINEEVDKIPAGSNGIIFLPYLNGERTPHRDPFARGVFFGISSYNTKWDMVRAIFEG VAFGIKDSFDILRELKVVLNSVRITGGGSKSRVWNKMLADMTGLRIQKPAVDEGASYGAAILAVSGSMGENPAKI SKEWFRVKSYTDPAVENTETYEKLHEKFKKLYTSLKEMFRS Thermotoga maritima NYSGXRC-6216e SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC747 ICEDB: T1933 GENBANK NP_462574.1 MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLAHTGVSGSQIRGL GISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYA QIGCVMMTHDYLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALSPVVGSAEICGEITAQAA AITGLAAGTPVVGGLFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEAS PTSSGNLEWFTAQWGDLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGV VFSHMTHLNRMRERFTEVCALRVTGGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREA QRDLQHPVRTLLPDMTAHALYQRKYRQYQDLIEALQGYHARIKEHAL Salmonella typhimurium NYSGXRC-6216f SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC747 MNDKNYLLAIDNGTQSVRALLFDLQGNLLGKGKVELEAYYSKHPGWAEQDPEYYWAMLGEACRRLWDQVDIDRGLI RGVSLTTQRGTVIHVDAEGRPLRPAILWLDQRRAEVRERIRGPWGWLFKLVGAEGAVEHFRAQAEVNWVAQEQPE IAAKTDKVLLLSGFLSHRLTGRFVDSVGCCVAYLPFDYKRLRWAAPRDWKWQALAVRREQLPELFKPGERLGEIS AEASRHTGIPQGLPLIAAGADKACEVLGAGALEPTIACLSYGTTATINTTRARYLETVPLIPPYPAAIPDHFNTE VMIYRGYWMVSWFKREFGLREMQQAREQGVEPEQLFDELVNGVPPGSMGLTLQPYWSPGIREPGLEAKGAMIGFG DVHTRAHIYRAILEGLAYALRQGKERIEKRSGTPIVRLRVAGGGSQSDAAMQLTADIFGLPAERPHVYEASGLGA AIDCAVGLGLYPDVASAVAGMTRVGRVFLPQAEARQIYQRLYGEVYLRMYRQLRPLYRSIREITGYPA Pseudomonas aeruginosa NYSGXRC-6216g SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC747 ICEDB: T1895 GENBANK NP_439187.1 MHYYLGIDCGGTFIKAAIFDQNGTLQSIARRNIPIISEKPGYAERDMDELWNLCAQVIQKTIRQSSILPQQIKAIG ISAQGKGAFFLDKDNKPLGRAILSSDQRAYEIVQCWQKENILQKFYPITLQTLWMGHPVSILRWIKENEPSRYEQ IHTILMSHDYLRFCLTEKLYCEETNISESNFYNMREGKYDIQLAKLFGITECIDKLPPIIKSNKIAGYVTSRAAE QSGLVEGIPVVGGLFDVVSTALCADLKDDQHLNVVLGTWSVVSGVTHYIDDNQTIPFVYGKYPEKNKFIIHEASP TSAGNLEWFVNQFNLPNYDDINHEIAKLKPASSSVLFAPFLYGSNAKLGMQAGFYGIQSHHTQIHLLQAIYEGVI FSLMSHLERMQVRFPNASTVRVTGGPAKSEVWMQMLADISGMRLEIPNIEETGCLGAALMAMQAESAVEISQILN IDRKIFLPDKNQYSKYQHKYHRYLKFIEALKNLD Haemophilus influenzae NYSGXRC-6216h SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC747 GENBANK NP_356760.2 VRAAKRHGISIIVAEKNLILGLDVGNTVIKAVLFDTAGRQIAQHAIDGHSTYPQPGYVERDLEELWRNGCEAIRQL LVKSAVDPNSIAGVGCAGHGNGLYLLDKEQQPLLGIQSLDSRAADMAAELDRKSGDLLQARCLQRPWPAQTPTLL AWVKRHALDLYAQTSTVLFCKDFINFRLTGCLANDISDLSGAGLLALPEVLLDRELLSLYGLEDAFAFFPRCVES ADIVGQVTREAAGLTGLSEGTPVIGGFFDVVSSAMGSGVINPGEASVIAGTWSINQVFADKPVVSPDVFMVTTFG RDRYVNIESSATSAANLEWYVHRVRADHGDHAFERCNELVGSVTPRADDPFFHPFIFGSRLGAEFRGGFYGLAGW HGEGHMVRALFEGVCFEHRRHIGVLREAGLPVESAVMSGGGSRSQHWPQIMADVLEIPLRVAEARETGALGAALG AAVATGLYPNYEEAVAAMTRVQNSYQPDTARVSHYRRRYGLYQELTGQLRSFWSALRLPQ Agrobacterium tumefaciens NYSGXRC-6217a SGX Pharmaceuticals 2004-07-14 active Selected Cloned Expressed Soluble EC642 GENBANK NP_414724.1 MTEQRPLTIALVAGETSGDILGAGLIRALKEHVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLL HIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPVEK AFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDL EIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFW LAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQA VLELAQ Escherichia coli NYSGXRC-6217b SGX Pharmaceuticals 2004-06-09 active Selected EC642 MIQAPRIALIAGEASGDHLGAGLIQQLRLRLPTAEFVGIGGDMMRSARCQTWFDTSELAVMGLTEVLRHLPRLLKI RREFCKRALAWHPDVLIGIDAPDFNLTVERWFKQRHIRTVHYVSPSIWAWREKRAAKIGASVDRVLCLFPMEPPI YARYGIDARFVGHPMADEIPYQTDRATARTALGLPLLSPVLAVLPGSRHSEISQLGSTFLEAAGQLSEHLPGLHV VIPAANTQCKPLLAEQLSRSTLPVMHSHLLDNSARTAMLAADVVLVASGTATLEAMLLKRPMVVAYKVAPLTYRI VKTLKLLKINRFALPNILAGEDLAPELIQKDCTAPALCAALLDWFKHPQKVTALQNRYLQLHTQLRRNASTRAAE AITELLPQR Xylella fastidiosa NYSGXRC-6217c SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble EC642 GENBANK NP_143143.1 MKFAAGFVLIDAPHSALNMLGIDESLPDRNVTRVKTLRRGGNRYVYISPQAWRYWWRITLKEYFNWELSPLFREEK QVFTAANPIKYPDDDVFGYMRAYKKNKVNVTVTRISPLKNTPLVSVLPDRSSLTIDEGYASRHEGDPVPYSQEFY STVLKGAFSLDLDLVGRFTTKNKAGYKNLLTRDDIPKKGKGEDIVKEIKELEELARNVGVEIKDGEWIMPKEIRK KRSIETIKALRYLTGGAKQTQYHTDVTPKLFLGIIVNGGINPFISDIVREEKGEIILDAEALATRLEDFSDIIDS KLFLGYDMGFVRSLGLEIEAIKSTAGIEVVEGKVGEIIEKFAEEAGKYYI Pyrococcus horikoshii NYSGXRC-6217d SGX Pharmaceuticals 2004-05-17 active Selected EC642 MPLTVAPATLLVSNGHAEDLIGAALARELRRRRPDQPLLALPLVGAGGAYAGLAETAGPLLDMPSGGFPFGSLDNL RADLRAGLVQKSLGQWLAARTQGPALERVVVVGDTYALGVGTLAARQIPGALARPRLPLVHVQPLVSVLYGEGMT LGGHLRELNALGANVFMPWELALGRRAWRVYTRDAASARHLARRGVNAAYRGSFALDILPAPERDLAPLLTGVPV LALLPGQRGDAQTSLPVMLGAACALPDMQALVAWPRPFDELPPLLGWTLEERGEWGVLARRGTCSVWLLRASFST ILHAAAASGGVALGTAGTANEQAAGLGVPVVGFPTAGPQYVPGFAVRQQRLLGAALTLTRPEASAAAQAVRELLG GPQRTTAVRDGQRRIGQAGALPQIAEELGKMA Deinococcus radiodurans NYSGXRC-6217f SGX Pharmaceuticals 2004-05-17 active Selected EC642 VTINRDKPLKVMLVAAEASGDALGAGLAKALRARLGQGVTFVGIGGAKMAEQGVQSPFDIAQLSILGILESLKAYP RAMARLKDTVALAAREKPDVAVLIDSWGFNIRLAHALRRLDPTLPLVKYVAPQVWAYREGRAQALAKAVDLLLSI QPMDKAYFDAAGLQNVFVGNSALAKRFDHADPGRLRAAIGAAASQQILLVLPGSRPSEIERVMPAFEDAVRRLKV ERPDLHIVVPAAYTVAEAVKARVAGWPFRAHVIEDEGLKDDAFLAGDVALACSGTVTTELALAGRPMVVGYKTGA VTYAIVKRLMKPRWITLFNIAAGKAVAPELIQHACEGEGLAREVALRLDDPDLRQRQTAEQYAALDRMGRGMPDP SEAAAEALLDFLSARGALGRAG Caulobacter crescentus NYSGXRC-6217g SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC642 VKKIFLSLADRSASNYVYEILKEGFEEYEIYGLTDEKLEKIGVKSVARYSEISTVGLIEALPKVFKFLKIYRKILK NLKNTDTLIACDAPALNLRLIKDARKLGVKRIIYFISPQVWAWKPKRAEIIANYCDHVIVILPFEKKIYRKFPNL KVHYVGHPLVDLVKPQKTKEEFMKAFKKEPLPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFIE RELKVKTLTYEGASYDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPYISLVNILLKEE VVPEFIQKSSDEILKGFEKVYKNEEEIKEKLGTLKFILGERFVIRKLRELFLEIV Aquifex aeolicus NYSGXRC-6217h SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC642 LKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKA IKELANLSFTQKINGILCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDN QFFNKSTYIGHPLLDEIKEFKNQEDINHTFSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGKKILCVPSF NLEKLEVYGDISEFKIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLAN IFCDFAGKEALNPEFLQDKVNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILNEI Campylobacter jejuni NYSGXRC-6217i SGX Pharmaceuticals 2004-07-01 active Selected Cloned Expressed Soluble Purified EC642 ICEDB: T1896 GENBANK NP_439218.1 MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLK IRKNVIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKA FYDKFNVPCRFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQ FLVPLVNEKRRIQFETIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFL AKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQA AQAVIDLLEGKENV Haemophilus influenzae NYSGXRC-6217j SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC642 LTQPPAAPARRIGMAAGEASGDLLASLLLKGLHARLPRDVAYEGIGGARMAEQGFASHWPMHKLSVNGYVEVLGQL REILAIRRELKQNLLADPPMAFIGVDAPDFNFNVEIAMRRAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLF PFEPEIYARAGIPATYVGHPLADEIPLEPDVEGARSRLGLPLGRKVVAVLPGSRNSEVKLLGPTLFAAMARMQAV EPDLAFVLPAANAMLRERIDAMRAEHPGLHLWVVDGQSHAAMEAADVILLASGTATLEAALYKKPMVITYKVPWL TAQIMKRKGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLSDHANAAFLREHFTQMHLTLKQNMADIG AQVVVDLLRGRGKL Ralstonia solanacearum NYSGXRC-6217k SGX Pharmaceuticals 2004-07-30 active Selected Cloned EC642 MADGLRVALVAGEASGDILGSGLMQALRARHPDIEFIGVGGPRMEAEGLSSYFPMERLSVMGLVEVLGRLPELLRR RKRLIRTLIEARPDVMIGIDAPDFTLGVEHKLRQAGLRTVHYVSPSVWAWRQKRVLKIREACDLMLALFPFEARF YEEHGVPVRFVGHPLANTIPLQADRAAARARLGLPADGQVLALMPGSRGGEVGKLGALFLDTAQRLLVERPGLRF VLPCASAARREQIEQMLQGREPLPLTLLDGASHEALAACDAVLIASGTATLEALLYKRPMVVAYRVAGLTYRILK RLVKSPYISLPNLLAGRLLVPELIQDAATPQALAATLSPLLDDGSQQVEFFDAIHRALRQDASAQAAEAVLQLVE RR Pseudomonas aeruginosa NYSGXRC-6217l SGX Pharmaceuticals 2004-06-09 active Selected EC642 MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLL HIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEK AFYDKFNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDL EVVVPLVNAKRREQFEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFW LAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADA VLELAQ Salmonella typhimurium NYSGXRC-6217m SGX Pharmaceuticals 2004-06-09 active Selected Cloned EC642 MRIFISTGEVSGDLQGALLIAALQRQAVALGVELEIVALGGDKMAAAGATILGNTSGIGSMGIFESLPYVVPTLIV QRRAIAYLKQNPPDLVVLIDYMGPNLGVGTYMQKHLPHVPVAYYIAPQEWVWSMSLRNTSRIVGFTDKLLAIFPE EARYFSHNGADVTWVGHPLIDRMQEVLSREEARAKLGITPEQKAIALLPASRKQELKYLLPPIFQAAQNIQAKLP EAHFWIPLSLEVYRQPIEAAIKSYGLQATIVSGQQKEVFAAADIAITKSGTVNLELALLNIPQVVVYRLHPVTVW IARKILKGSIPFASPPNLVVMKPIVPELLQEQATPENITQASMELLLNYERRKQTLADYQEMRQCLGELGVCDRA AQEILQML Nostoc sp. NYSGXRC-6217n SGX Pharmaceuticals 2004-07-06 active Selected Cloned Expressed EC642 VNRPLRIGIVVGELSGDTLGEGFIKAIRARYPDAEFVGIGGPKMNALGCQSLFDMEELAVMGLVEVLGRLPRLLKV KAELVKYFTANPPDVFVGIDAPDFNLRLELSLKQAGIKTVHYVSPSVWAWRQNRIHGIAAATHLVLAFLPFEKAF YDKFNVPCEFIGHTLADSIPLASDKLAARQLLGLDEQRRWLAVLPGSRGSEMKMLAEPFIATCQKLQARYPDLGF VVALVNAKRRAQFEQAWQQVAPELNFVLVDDTARNVITAADAVMLASGTVALECMLLKRPMVVGYRVNAFTAFLA KRLLKTPYVSLPNILAGEELVKELLQDHCTVDNLYHEVSRLLESDNQALMDKFTEMHQWIRKDADQQAAQAVLHL IQK Vibrio cholerae NYSGXRC-6217o SGX Pharmaceuticals 2004-07-27 active Selected Cloned EC642 MKFAAGFVLIDAPHSALNMLGIDENLPDRNVTRVKTLRRGGNRYVYVSPQAWRYWWRTTLKEYFKWELSPLFREEK QVFTAANPIKYPDDDVFGYMRAYKKNNVNVTVTRVSPLKNTPLISVLPDRSSLTIDEGYASRHEGDPVPYSQEFY STVLKGAFSLDLDLVGRFTTKNKAGYKNLLTRSDIPKKGKAGEIVKEIEELEKLAREIGVEIKEEEWIMPKEVRK KRAVETIKALRYLTGGAKQTQYHTDVTPKFFLGIIVNGGINPFISGIVREEKGEIILDAEALATRLEDFSEIIDS ELFLGYDKGFVKELGLDIEALKSAVSIEVMEGKVGEVIESFAEEAGKYYL Pyrococcus furiosus NYSGXRC-6217p SGX Pharmaceuticals 2004-06-09 active Selected EC642 MWGQTNMADKKSPLIAVSVGEASGDLLGAHLIRAIRKRCPQARFTGIGGELMKAEGFESLYDQERLAVRGFVEVVR RLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAEKLKRSGIPTVHYVSPSVWAWRRERVGKIVHQVNRVLC LFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRETARQTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLLL ERYPAARFLLPAATEATKRRLAEVLQRPEFAGLPLTVIDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYK ISPLTYAYVKRKIKVPHVGLPNILLGKEAVPELLQSEAKPEKLAAALADWYEHPDKVAALQQDFRALHLLLKKDT ADLAARAVLEEAGC Neisseria meningitidis NYSGXRC-6217q SGX Pharmaceuticals 2004-07-15 active Selected Cloned Expressed Soluble EC642 GENBANK YP_001928322.1 MRYFIVAGEASGDLHASNLVRALKEHDPEAVFAFMGGDFLSEATGERPIFHYREVAFMGFIPVLTHLGVIRRAGEH VQEQMRAFNPDVVIAVDYPGFNMRYVLPFVREELGKPIVYYISPKVWAWKSWRIKTLKKYVDLMLCILPFEKDFF AGHDFPVIYVGNPCYDAVKQHMRPTIEEQERSAKDSRQVALLCGSRLLEVKENLPVMLRVMKQFPDYRPVIAGAP GLTIQDYTPFLPDDSIPVVFGRTYEILRESKAALVTSGTATLETALIGTPQVVCYYIRGGRLTNLIFKYCFGTPF ISLTNLIAGRAVVPELFGALFTEKRLAASLSPLLDASSAERQAQLSGYDSIRKSIGTDNTSDKAARHIIARFAKD NARPSSL Porphyromonas gingivalis NYSGXRC-6217r SGX Pharmaceuticals 2004-01-19 active Selected EC642 MQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYV SPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLAL LPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAA LLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLA NGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ Shigella flexneri NYSGXRC-6218a SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2047 GENBANK NP_249906.1 VLLDNSYRNLCLIYAVMRAGKHLVLIDPEWGEAAKQAIVDEMRLEALASEHPLEGALAGLRLALDFERSATRRLDR AAHSHMILFTSGTTGQPKGIELSQQAMLHAYRIGRDCLGIGEHTRSGCFYRISGLGILGINFLFPLLYGGSAVLL PLHCWADSEGFWECVERFGISFLYLVPPVVNHMVKEGSPPPRRLPLQRLLCVAGSARLDADLQAAFQRDYAALAN IYGLSECGFAFLFGKRRGDAFDNSVGPAVGLELKLTDPDGRPLEGSGERGRLWVRTPSLFSGYVNRPDLTAQVLE DGWLNTQDLAYFDEDRCVHVLGRCDGTINKGGNLFHLNECERALNGLDEVIDVCCLKVDCPLYGEDYVAVIHTAP QVEFAFLPWLQQQLGTLRAPQRVVLSHQALPLNGAGKHDRRALAALLQREAS Pseudomonas aeruginosa NYSGXRC-6219a SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC1975 VSAATDLYAVHQALAGESRAIPTGSCPTVGVAGLTLGGGLGADSRHAGLTCDALKSATVVLPGGDAVSASADDHAE LFWALRGGGGGNFGVTTSMTFARFPTADCDVVRVDFAPSAAAQVLVG Mycobacterium tuberculosis NYSGXRC-6219b SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC1975 MTLDVTRQDPRYDTLRHGFNLRWPSSDAQAAGRIALCEKTDEVAPALQRIIDTGMRPTVRSGGHCYEDFVSNNPGG VIVDLSLLNAPEVRADGAVRVPAGMQNWNGALELYKRHGVTLPGGSCYSVGAGGHISGGGYGLLSRLQGLTVDWL SAVDIVTVDKQGRAAPRTVDAARDPDLFRACRGAGGGNFGIITSYTFARLPEAPREVALATVAFDWAAMTPERFA ELLRLYGDYWATRGKDPDTWGLFSLLKLTHKSAGQIVMLTQFCNPDGTCRDLSVLNDFLARFQVCAPVPARARPP GYGPAHRQGVGQLLCSKPHTVVQYDWLTATQSLNGSGPNQRGKYKSAYMKRGFTAREAQRIYTHLTRTVQGIDLS QSLLQVDSYGGAVNKAERIADTAVPQRASVMKLQYQTYWTSAADDAGHLRWIGDFYRDVYGTPDVSAPHAGTPYP GDRYEGCYINYPDVDMLAYPFWPQLYYGDGDLYAFLQRVKRRYDPNNIFHHAMSVRP Ralstonia solanacearum NYSGXRC-6219c SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC1975 LLAKEVKEKLIKIVGLENVEDSPVERLVYSYDATPQFQALPDAVVSPRNTKEVAEIVKICNEYNIPIVPRGSGTNL CAGTCPTEGGIVLLFKHMNSILEIDEENLTVTVQPGVITLDMIRAVEEKGLFYPPDPSSLKISTMGGNINENSGG LRGLKYGVTGDYVLALEVVLANGEVIRTGGKLAKDVAGYDLTRLMVGSEGTLGIVTEATCKLIPKPESKQTMLAL YQDIEAAAQTVSSIIANKVIPTTLEFLDQPTLKVVEAHAQIGLPTDVQAVLLIEQDGPSEVVKREMEKMHALCEQ GQAISVQIAESEDEAEALRTARRSALSALARLKPTTILEDATVPRSEIANMVKVINEIAEKYELTICTFGHAGDG NLHPTCLTDIRNHEEIERVEKAFAEIFEKAIALGGTITGEHGVGVMKAPYLERKLGEAGMAAMKAIKEALDPNHI MNPGKVFAKDCRKRVVVSR Bacillus halodurans NYSGXRC-6219d SGX Pharmaceuticals 2004-01-19 active Selected EC1975 LLTRAAGLTCDSLVQLEMIVADEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWG WDDFEEVYNTWQNWPPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGSPTSGMVKTTPFIEA VTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQNASVWQQALGGAAGRVAPDQTAFYYRDAIIA QEYLTNWTSPGEKRQNVRWIEGLRTSLSKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQ SIPPLRRSLFF Bacillus subtilis NYSGXRC-6219e SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed Soluble EC1975 GENBANK NP_013624.1 MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARLAEKSLVTVGSGHSPSNMCVTDEWLVNLDRLDK VQKFVEYPELHYADVTVDAGMRLYQLNEFLGAKGYSIQNLGSISEQSVAGIISTGSHGSSPYHGLISSQYVNLTI VNGKGELKFLDAENDPEVFKAALLSVGKIGIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTSSEFIRVWW YPYTRKCVLWRGNKTTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPLTPFVEKFVFNRQYGKLEKSSTGDVN VTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLRSLDHSIAQAAINKEFYVHVPMEVRCSNTTLPSEPLDTSKRTN TSPGPVYGNVCRPFLDNTPSHCRFAPLENVTNSQLTLYINATIYRPFGCNTPIHKWFTLFENTMMVAGGKPHWAK NFLGSTTLAAGPVKKDTDYDDFEMRGMALKVEEWYGEDLKKFRKIRKEQDPDNVFLANKQWAIINGIIDPSELSD Saccharomyces cerevisiae NYSGXRC-6220a SGX Pharmaceuticals 2004-11-29 active Selected EC2231 MRRSLLFCGALLASLCAWAEPAQVRLLSSDFVLPGKHQRLAGWAREAGVELRGLRLGIGEAPPGEWLDGGNLLILD TPRPTDRAQVEEALGERLQGGTQPWIRVGGGPPGFGNLPAALGGRLVGYYANGGEANLRRLFEAVRRWHAGLTVD ALPAPQPLAQAGFYHPDAPAPFAVLADYLAWGASRWASDAPRIAFLIPRGAIADAQTGAIDELLRRSERHGQAPL AVWFDDSDPEALRKSFAGADVQALVNLQHLQNGPARRAEFLALDVPVLQTLGYRDGNEADWLAAASGVAPRTAAA FLGMPETWGMSDPLVISALENGEPKLMAGQAEALLDKLDRLLRLRRLPAADKHLALMFWNHPEGEKNVAASHLNV PASLARLGEALRAAGYRVATSDESALIDTAQRLLGGYYRPQTLDALYRDGLAASLPLDAYLHWFEALPADLREEM RARWGDPRRHWALRDIDGQRRFVFPAARLGNLLLLPQPPRAGRPGEAYHDSAVPPDHLYLAVYQFVREGFGADAL IHFGTHGTQEWLPGKDRGLAVGDYPLRALGDLPVFYPYIQDNVGEAIQARRRGRAVTVSHQTPSFAPAGLYDELR DLHQLIHEYQQLDEGAVRERSAEQIRAAVRAAHMNDDLGWSEAAMHEDFPAFLGVLHDHLHRLAGSAMPLGLHTF GVAASPELRLGTVMQQLGEPYYRALGLDPDELFAADFRALREGRAYRTLQRYLRDGGEIAKVADPRLREQLLRAR ELDRQLADTGELEALLAGLAGRFVAPGPGGDPIRNPQVPSGRNLFAFEADKVPTRAAYEAGAEAFGQLLESYRAE HQGRAPEKLAFSLWSSETMRHLGIVESQALHALGLRPRWDAGGRLLALDIVPAAELGRPRVDVVLQVTSVYRDQF DGFMRLLAEAIERLAALDEPGNPLARNSQALERRLRERGVEAPLAQRLSRLRLFGNAPGDYGTGVTQLTLDSTRW DDDSALAEQFLGRLQYAYGSRDWGVKLDGGNLFAEQLKGVQAAILSRSSTLNGVLSTDHPFEYLGGLSLAVRHLD GASPALYIADLRQRQPRTTAAAQFLASELRGRYLSPQWIAAMQREGYAGSLEMLDLANNLWGWQAADRIMVRADQ WQALHDTFVMDRRELGLAEWFETHNPTAQAQIIARMAEAIRKGYWDASEQTRRELAERWRQLAAAGAGEVGAATT REFIERMAGGFGEAAAQAEGAAASGAGETVSGRVLEEVAPPPSGEPQPWLRLAAAVLLALFAAGAVRQSVVNRRP MENRS Pseudomonas aeruginosa NYSGXRC-6220b SGX Pharmaceuticals 2004-05-17 active Selected EC2231 MHILATTSSSLDDLIEPVDLNQPRSDVVVLSFSASDLAGLERAWGKAGETLPSLSAANLSELRHPMSVDLWIEKTA EHARVILIRILGGAERWRYGVDQLAILARRRGIKLLLLPGECSERDEKLEAASTVDKPMLASVLSFFREGGRENM GRLAAGLSVLAGGGEWPDIKADPLPKAGFYRPDLGVVGQDEACAGFPAGASVLPILFYRSMLLAEDAAPVDALFQ ALSARGFAPLPIFVSGLKDGEAIRFLETVLPALQPAAIIAATAFASHTDDRGETLFDRLGVPVFQAVMATTRRVG WVENARGLNPSDLAMHVVLPELDGRILTGAISFKQARTDGGVSLVNVPEADRIEQVANRIAAFLRLKSAPPRDRR IVILMPDYPGAAPGRTGYAVGLDVPQSVLEMLRDLAEAGYAVEDIPETARALLDRIESQEATVDLSTYRDFFAGL TETASSSMNATWGAAEQDDAFADGAFHFRVARFGQVFVALAPDRGRNEDRRVDYHDPALPPRHALVAFGAWMQSV VATHAIVHVGAHGTLEWLPGKTVALSRDCFPEIVTGPLPVVYPFIVSNPGEAAVAKRRIAAVTIGHVPPVLVNAG LSPEQLALEQLVDEYAQADGLDRRRRDRLAKLIVEKALETGLAAEAGVGAKDDADAALSRIDAFLCDLKDFAIKD GQHVFGRSPEGEADPLRLQSAKAEKAALLAALDGRHIAPGPSGAPARGRLDVLPTGRNLYAADPRTMPTPTAFDL GRMAGEEVLRHHLQSHGDWPKHLVFDLWGSASLRNGGEDVAQALHLMGARPIHDPATGRVTGIEVLPPASLGRPR VDVTFRISGLFRDMFPALIALLDAAAKAVARRDEAPGDNPLAEEAAALGHIPARIFGSAPGTYGAGIEEKLASGT WDEREELGQAYLDAANHAFGGADGLEIFEDAGFTELVRRADLLVHTGDDPGRDLLDGSSDVAFIGGFSAAKAVLG GIADIVALDTTDPARPRARSMTQALTRVVRARAVNPRFIAGQMRHGPRGAAEFAETVDRLVGFAETTHVVSSSLI EALYDAYFGNEEVRDFILRENPKAAEVMAARFLSARRRGLWHSRRNAVDAELEMLILPRSERVGA Agrobacterium tumefaciens NYSGXRC-6220c SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC2231 VPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAEASIVVIRILGGYRAWQSGIDTVIAGGVPAVL VSGEQAADAELTDRSTVAAGTALQAHIYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGVLERPDAGKT GPTIAVLYYRAQHLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVKPAAA SAGGDDDSWNVEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEFDGRIITVPFSFKEIDDDGLI SYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAYPTKHARIGNAVGLDTPASAVALLQAMRQRGYRVGDL PGVESNDGDALIHALIECGGHDPDWLTEGQLAGNPIRVSAKEYRDWFATLPAELTDVVTAYWGPPPGELFVDRSH DPDGEIVIAALRAGNLVLMVQPPRGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFSNGFGAHAVVHLGKHGNLE WLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHAVLVDHLIPPMARAETYGDIARLEQLLDEHA SVAALDPGKLPAIRQQIWTLIRAAKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQNPTGEQ ELDLVLAILRARQLFGGAHAIPGLRQALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSAADRLTGNADAA AVLRFAATEVIPRLAGTATEIEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWEAGVAL ADSLLARYRDEHGRWPRSVGLSVWGTSAMRTAGDDIAEVLALLGVRPVWDDASRRVIDLAPMQPAELGRPRIDVT VRISGFFRDAFPHVVTMLDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYGAGLLQLID SRSWRDDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVATVRA LTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYDATAGVMAD WMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAGRGLWAQPAPETLDGLRQVLLETEGDLEA Mycobacterium tuberculosis NYSGXRC-6220d SGX Pharmaceuticals 2004-07-01 active Selected Cloned Expressed Soluble EC2231 GENBANK NP_049503.1 VCCISFRVGTGPCVTSGADRLTKGPLRKSAPVSQPEANPKSRSFSGNFLNHTFRRENPMSEITSLVTAEAVKDVLR SEEVRSALKQKLRHNLEARLDAEVDAILDELLGVQAEPPTEAGDTTAESGEVQPESPVADATEPQPESVMML Escherichia coli O157:H7 NYSGXRC-6221b SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC1606 GENBANK NP_274506.1 MALIVHKYGGTSVGSPERIKNVAKRVAKARAEGHDIVVVVSAMSGETNRLVALAHEMQEHPDPRELDVVLATGEQV TIGLLAMALKDIGVDAKSYTGWQVALKTDTAHTKARIESIDDEKMRADLTAGKVVIVAGFQGISSEGDISTLGRG GSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEARRMDTVTFEEMIELASLGSKVLQIRSVEFAGKYKVRL RVLSSLQDGGNGTLITFEEDDNMERAAVTGIAFDKNQARINVRGVPDKPGVAYQILGAVADANIEVDMIIQNVGS EGTTDFSFTVPRGDYKQTLEILSERQDSIGAASIDGDDTVCKVSAVGLGMRSHVGVAAKIFRTLAEEGINIQMIS TSEIKVSVLIDEKYMELATRVLHKAFNLG Neisseria meningitidis NYSGXRC-6221c SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC1606 VSRLVMKFGGTSVADLERIRRVARLVAAEVATGKQVAVVVSAMSGKTNELVAWTDGAGRAAAGLPESDDEYDAVVA SGEQVTAGLLAMTLRNMGHKARSFLGWQVPILTDEAHGRARIEEIPPENLEECFANGEIAVIAGFQGVTPNRRIT TLGRGGSDTSAVAIAAAVKGDCDIYTDVDGVYTTDPRIESKARRLAKISYEEMLEMASLGAKVLQTRSVEMAMAH RVPVRVLSSFVEPGEAPGQGTIVCDEEEIMEKRIVSGVAYSRDEAKITLLGLPDHPGVSSQIFGRLAEANVNVDM IVQSRARSADTANMEFTVGKRDATRAVEIVQAAQKEIGFEAVAVNEDVAKVSVIGVGMRSHAGVAQSMFQALAEK NINIQVISTSEIKISVLIDAAYTELAVRALHAVYGLDQL Caulobacter crescentus NYSGXRC-6221d SGX Pharmaceuticals 2004-06-23 active Selected Cloned Expressed Soluble Purified EC1606 GENBANK NP_243266.1 MKIIIQKFGGTSVKTAEVREMAAKHVEKAVEGGYKVVVVVSAMGRSGDPYATDTLLQLVDTKTIAKREQDLLVSCG EIISSVVFTELLLKKGIQATAMTGAQAGFRTNEEFTNAKIVDMKVDRLKKTLVHQDVVVVAGFQGQSPTGETTTL GRGGSDTSATALGAALDAEWVDIFTDVEGIMTADPRIVSEARPLDTMTYNEVCNMAYQGAKVIHPRAVEIAMQAK IPIHIRSTYSDGKGTLVTSMLTEAGARDVQDRIITGIAHMSGVTQIKVHAKDGEFDLQEKVFRAMAAEKISVDFI NINLTGVVYTVMDEVADRAIEVLRELGFDPEVKRHCAKVSAVGAGMTGVPGVTAKIVAALSQENIRILQSADSHT TIWVLVSEDDLTKAVNALHRMFHLEQSEQTKQKQV Bacillus halodurans NYSGXRC-6221e SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC1606 GENBANK NP_295088.1 MSQPQPPSRLLVMKFGGTNMQSAHAIRHSASLAGRSVREGVKVVVVVSAMAGVTNGLLHLADAAQSGDIARANDEI AALRTRHFTAAQELGAAPDSETVRELRELHETLRQAVYGVYLLRELTPRSRDLIVAFGERLSAPLMSLALEQSGL RARHLTGGEAGILTDTNFGNARPLPGTYERVGDRLSGFLSAGVTPVIAGFMGETEQGAITTLGRGGTDFSATIVG KALGADEVWAWKDVDGVMSADPRVVGDASNIGVLSYGEVMELAYFGAKVLHPLAVTPLQDSGIPLRVKSAADPDF AGTLVRSQAEEIPGRPVKAVTAIKNVSLLTVTGAGVLGVPEVIASVFTAIARENITLLMVSQSSSMSNVSLAVPS ADAARALQALRAGLSSELNVEETNGVAVLAIVGSGMRGQQGVSARLFTALASEDINILMISQGSSELNISVALSG EEVDRATAAVHAAFTLSQPVGA Deinococcus radiodurans NYSGXRC-6221f SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC1606 ICEDB: T1898 GENBANK NP_464961.1 MKIIVQKFGGTSVQNEKSRLMAFNHIKQVLKEGYKVVVVVSAIGRYGDPYATDTLLELIGAKNTKLTAREQDTLLS VGETISASVFTNMLKEANIKAEAFSGGQAGIITSDDHLNAKITEVDTARLKDALTNLDVAVVAGFQGITANGDIS TLGRGGSDTSAAALGVSLQANYIDIFTDVDGMMTADPRIVEHARSLPRVSYNEVSNMAYQGAKVIHPRAVEIAMT AKIPMRIRSTYLESTGTLVTSLADDSGHFDVKERMVTGVAHVTNLTQISVQADTVKAQQLAFKILADAGISLDFI NISTNSVIFTVPEEKSHVVKQLLEDADLQTTVRQACAKVSIVGAGITGVPGVTAKIVGALSEKNIPILQSADSHT TIWVLVREKDLISAVNALHDVFCLEIK Listeria monocytogenes NYSGXRC-6222a SGX Pharmaceuticals 2004-05-17 active Selected EC2218 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFEGFAARGIG HDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADM LALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAF AVAHTGKPVIVYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPR G Mycobacterium tuberculosis NYSGXRC-6222b SGX Pharmaceuticals 2004-07-16 active Selected Cloned Expressed Soluble Purified EC2218 ICEDB: T1917 GENBANK NP_721350.1 MGRFKTLLNQEDYLILHGALGTELEFLGYDVSGKLWSAKYLLENPSIIQTIHETYLRSGSDIVTTSSYQASYQGLC DYGLSQEEAEKMIALTVSLAKNAREKVWQELSEKEKQVRPYPLISGDVGPYAAYLADGSEYTGNYGQLDKEVLKD FHRSRIKILVDEGSDLLALETIPNFLEAQALVELLQEEFPSVEAYMSFTAQNGTTISDGTAIEEVAELIDKASQI LALGINCSSPSVYSSLLKKIADITDKPLVTYPNSGEVYDGQHQMWTQSADISHTLLENTKIWHTFGAKVVGGCCR TRPNDIESLSRGLRE Streptococcus mutans NYSGXRC-6222c SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2218 GENBANK NP_465203.1 VNLRKDLSEKVLIADGAMGTLLYSYGVDRSFEELNLSHPEDIVAIHKAYIGAGADIIQTNTYGANYIKLARYGLED EVKRINQAAIRLAKEAARGTGTYIFGTIGGINGAVDARLPAAPLEEIKRSFREQLYCFLLDGVDAILLETYYDLD ELKTVLKILRETTDLPVVANVSMHEPGILQNGKKLPDALEELIALGADVVGINCRLGPYHMARALETVPLYDNAY LAVYPNASLPEMQEGKVIYQSDTDYFEHYGEVFRQEGARIIGGCCGTTPDHIRALRKGLETTKPILEKEVRPILE LVPEEVEDVDSGERLLDKVKERLTILVELDPPRTFDTTKFFEGAQALDEAGVDAITISDNSLATPRISNMALASI LKHEYGIKPLIHLTTRDHNLVGMHSHVMGFHKLGLHDVLAITGDPTKVGDFPGASSVFDLRSVELVQLIKKFNDG ISYTGKSLKEKARFHVGAAFNPNVLNLEKAVRLIERKVEYGADYIITQPIYDVNKAILLKEALQKANIDVPLFIG VMPLLSSRNAEFLHNEVPGIRLTDDVRERMREAEEHGHANEEGMAIARELVDAICEHFQGIYIITPFLRYDLSIE LAKYAQNKQQVQIGSK Listeria monocytogenes NYSGXRC-6223a SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3665 MKRFNVLKYIRTTKANIQTIAMPLTTKPLSLKINAALFDVDGTIIISQPAIAAFWRDFGKDKPYFDAEHVIHISHG WRTYDAIAKFAPDFADEEYVNKLEGEIPEKYGEHSIEVPGAVKLCNALNALPKEKWAVATSGTRDMAKKWFDILK IKRPEYFITANDVKQGKPHPEPYLKGRNGLGFPINEQDPSKSKVVVFEDAPAGIAAGKAAGCKIVGIATTFDLDF LKEKGCDIIVKNHESIRVGEYNAETDEVELIFDDYLYAKDDLLKW Saccharomyces cerevisiae NYSGXRC-6223b SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC3665 MIPEACLFDMDGLLVDTESIYTKSTNIILKRYNKGPFSMEVKAKMMGRTSKEASRIFLDWSGIDLTCEEYIALQRE TQAELWRHTKPLPGVMNLLSKLKSLNIPIALATSSDTHNFEKKSAHLSHLFDHFDGNIITGDDPRLPVGRGKPHP DIWFIALKMINDKRKAQGQAEILPENCLVFEDSITGVQSGRAAGMKVVWVPDVNILPFFSLSPEQAADKHITKVL SLENFDVTKV Schizosaccharomyces pombe NYSGXRC-6223c SGX Pharmaceuticals 2006-11-21 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC3665 ICEDB: T1899 GENBANK NP_213923.1 PDB 2NYV MRVILFDLDGTLIDSAKDIALALEKTLKELGLEEYYPDNVTKYIGGGVRALLEKVLKDKFREEYVEVFRKHYLENP VVYTKPYPEIPYTLEALKSKGFKLAVVSNKLEELSKKILDILNLSGYFDLIVGGDTFGEKKPSPTPVLKTLEILG EEPEKALIVGDTDADIEAGKRAGTKTALALWGYVKLNSQIPDFTLSRPSDLVKLMDNHIVEF Aquifex aeolicus NYSGXRC-6223d SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble Purified EC3665 ICEDB: T1900 GENBANK NP_229059.1 MEAVIFDMDGVLMDTEPLYFEAYRRVAESYGKPYTEDLHRRIMGVPEREGLPILMEALEIKDSLENFKKRVHEEKK RVFSELLKENPGVREALEFVKSKRIKLALATSTPQREALERLRRLDLEKYFDVMVFGDQVKNGKPDPEIYLLVLE RLNVVPEKVVVFEDSKSGVEAAKSAGIERIYGVVHSLNDGKALLEAGAVALVKPEEILNVLKEVL Thermotoga maritima NYSGXRC-6223e SGX Pharmaceuticals 2004-06-25 active Selected Cloned Expressed Soluble Purified EC3665 ICEDB: T1901 GENBANK NP_388805.1 VIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVIGTAAGFRPFEYLEEQIGKKLNHEELTQLRRER FAKRMESEKARPGVEAYLNAAKDLGLKIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAA KNLGVSPAECLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNSQN Bacillus subtilis NYSGXRC-6223f SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3665 MLDYEIFNPYEGLIFDMDGTLIDTMPVHAQAWTMVGKKFGYEFDFQIMYNFGGATVRTIAGEMMKAANMPLDRIED VLAAKRELSYQLIPTQSKLLPTFEIVKSFHQKKPIALGSGSHRKIIDMLMDKLAIAPYFNAIVSADDVKEHKPHP ETFLRCAELIQANPSRCIVFEDADLGVQAGLSAGMDVFDVRTREIISPR Haemophilus influenzae NYSGXRC-6224a SGX Pharmaceuticals 2006-10-02 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC4117 ICEDB: T1934 PDB 2IJZ PFAM PF02127 GENBANK NP_251937.1 MRAELNQGLIDFLKASPTPFHATASLARRLEAAGYRRLDERDAWHTETGGRYYVTRNDSSLIAIRLGRRSPLESGF RLVGAHTDSPCLRVKPNPEIARNGFLQLGVEVYGGALFAPWFDRDLSLAGRVTFRANGKLESRLVDFRKAIAVIP NLAIHLNRAANEGWPINAQNELPPIIAQLAPGEAADFRLLLDEQLLREHGITADVVLDYELSFYDTQSAAVVGLN DEFIAGARLDNLLSCHAGLEALLNAEGDENCILVCTDHEEVGSCSHCGADGPFLEQVLRRLLPEGDAFSRAIQRS LLVSADNAHGVHPNYADRHDANHGPALNGGPVIKINSNQRYATNSETAGFFRHLCQDSEVPVQSFVTRSDMGCGS TIGPITASQVGVRTVDIGLPTFAMHSIRELAGSHDLAHLVKVLGAFYASSELP Pseudomonas aeruginosa NYSGXRC-6224b SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC4117 MTATAKSCALDFLDFVNASPTPYHAVQNLAEHYMSHGFQYLSEKSDWQSKIEPGNSYFVTRNKSSIIAFSIGKKWK PGNGFSIIATHTDSPTLRLKPKSQKSAYGYLQVGVEKYGGGIWHTWFDRDLSLAGRVMVEEEDGRVIQYNVHIDR PLLRIPTLAIHLDPSANSSFSFNMETEFVPLIGLENELAKEETSDNGDKYHHPVLLSLLANEISKSLETTIDPSK IVDFELILGDAEKARLGGIHEEFVFSPRLDNLGMTFCASQALTKSLENNSLDNESCVRVVPSFDHEEIGSVSAQG AESTFLPAVLQRICELGKESSLFSISMVKSFLVSADMAHAMHPNYSSRYENSNTPFLNKGTVIKVNANQRYTTNS AGIVLLKKVAQLADVPIQSFVVRNDSPCGSTIGPKLAAMTGMRTLDLGNPMLSMHSCREMCGSKDFEYAVVLFSS FFQNFANLEEKIIIDE Schizosaccharomyces pombe NYSGXRC-6224c SGX Pharmaceuticals 2004-07-27 active Selected EC4117 MNQTVEYIKELTAIASPTGFTREIADYLVKTLEGFGYQPVRTSKGGVNVTIKGQNDEQHRYVTAHVDTLGAIVRAV KPDGRLKMDRIGGFPWNMIEGENCTIHVASTGEKVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDAKVTSEKE TRALGIEVGDFISFDPRTVVTETGFIKSRHLDDKVSAAILLNLLRIYKEEKIELPVTTHFAFSVFEEVGHGANSN IPAQVVEYLAVDMGAMGDDQQTDEYTVSICVKDASGPYHYDFRQHLVALAKEQDIPFKLDIYPFYGSDASAAMSA GAEVKHALLGAGIESSHSYERTHIDSVIATERMVDAYLKSTLVD Streptococcus pneumoniae NYSGXRC-6225a SGX Pharmaceuticals 2004-05-17 active Selected EC2730 MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQPGTGDAGGMNVYMLQSA LHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIV HSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVIS LHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGGP SGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGG LPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAE RQRRGGEVISDLVAVGKPRHWTPRRGVGA Mycobacterium tuberculosis NYSGXRC-6225b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed Soluble EC2730 GENBANK NP_578520.1 MRVLVMVNDFPNKDNSYTANIFVKEQVKALSEFVEEINVIVPIPRGIELYRKTSYRDYAIGENVHVHFVKYINPLF PIAYSKLRREWIWLEHRALTNFIKKKDIKFDIIHAHYTWPSGAVGVKLKEEYKVPLVITEHTSQTFNRYITTRDP LAREIWQKADIIVRVRKGDIDLFSRVGITPSKIRYIPNGFDGNKFYPIPQEIARRKLNLVEYEKIIINVANMYSR VKGHEYLLRAFSKVAENTSDAFLILVGSGKLLSHLKKLADNLYLGHRVLFAGSKPHDEIPLWMNAADLFVLPSLR ESFGVVQIEAMACGVPVVATRNGGSEEIIISEDYGLLCEPANPKELAEKILIALEKEWDREKIRKYAEQFTWENI AKKTLEVYRGVLK Pyrococcus furiosus NYSGXRC-6225c SGX Pharmaceuticals 2004-06-09 active Selected EC2730 VKLTMFQNKKHRIALISVSGDPAVEIGQEEAGGQNVYVREVGYALAEQGWQVDMFTRRISPDQAEIVQHSPNCRTI RLQAGPVEFIGRDHVFDYLPEFVAEFQRFQKRQGYNYQLIHTNYWLSSWVGMQLKKQQPLVLVHTYHSLGAIKYQ TIADIPAIANQRLAIEKACLESVDTVVATSPQEQQHMRALVSKKGRIEMIPCGTDINNFGNIEKSAAREKLGIEP DAKMVFYVGRFDPRKGIETLVRAVAQSRLRGEANLQLVIGGGSRPGQSDGRERDRIANIVAELELNDCTTFAGRL DHEILPYYYAAADVCVVPSHYEPFGLVAIEAMASKTPVIASNVGGLQFTVVPEVTGLLAPPQDESAFATAIDRIL ANPTWRDQLGTAARQRVETTFSWAGVASQLSQLYTHLLTQNAPEKKEKEAVAA Nostoc sp. NYSGXRC-6226a SGX Pharmaceuticals 2004-07-13 active Selected Cloned Expressed Soluble Purified EC871 ICEDB: T1918 GENBANK NP_417525.1 MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEA LCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGE AQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRL RPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKG MIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLF LRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQ WRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVLSR ITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYL LRVPEDDEEQQLEALRQFKQAPVLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNE REGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVD ARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREM REKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTR AYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE Escherichia coli NYSGXRC-6226b SGX Pharmaceuticals 2004-08-03 active Selected Cloned EC871 VMVSKKSLSTSVKGPAKDPAKQSLVGDVEPRCMVNLESVFAVLREQCPVSMQSDVQRLGAAFYCRMETDEFARRTP EQWAALVMGMLEFARVRSSGTVNVRACKPAIHVHGWDSSHTMLQIVNEDMPFLVDTVIMTLAELGIGVHLLFHPV IELTRDKENRLIAVGEGIAESLMVLEIDRQSAEQMAVIEKAIRKALDQVRAVVTDWRAMREHMLRLADAMDMRCV PSEALRHEMQAFLRWVAADHFIFFGYREYSVAKHGAEAVLASLQETALGLMRAQDVSPPRPMASFAAYRLSQSAG QDDALILTKTNARSPVHRVGYMDYIGVLEFDAEGRMIGERRFLGLFTSSAYYCRPWEIPFVRQRYQYVMNRSGLT LDSHSGKLLRHILETLPREELFQSGDEALYRTAMGILGLHHRVRSRLFLRCDKYQRFISALVYVPREYFNQDARL RIEALLKDVLHGEYIDSSVIVNELSPLAQLHLIIRPQSGYVLEPDDAQALEERVAHLLRNGQDALREVLVTRHGE DVGLRMAALYGRALPAGYLEESSIESAAVDVEHLAALQSPDDLRLSLHALPRAGSPGLRLKLYRQLDGIPLSDVL PMMENLGLRVISERLYRLHIAPVPMCIQDFEVQSAVGAIDVTAVGMTFVEAFVRIWDGNAENDGFNGLVLAAGLD WRQVALLRGYCKYLLQTGAPFSQSYVEATFAQYPLLARVLVELFDARFNPTIDDAPKRCMDNQPQRRVQLTALAD GDTAVLKVLEPMLEASFSDRHVYRDTVHAVLLKLMDRVANVDEDRILRSFVGVIDATLRTNYYQTGKQGPLGSCI SFKFDSTQIQDLPKPHPYREIFVYSPRVEGIHLRFGPVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGA KGGFFVKCLPSVADRDAIQAEGIACYTLFIQCLLDLTDNIVDGQIVPPAQLVRYDQDDPYLVVAADKGTATFSDI ANRLALEHGFWLGDAFASGGSVGYDHKGMGITARGAWESVKRHFRALGRDCQNEDFRCIGVGDMSGDVFGNGMLL SRHSFLVAAFDHRHIFLDPMPDAALSFAERERLFKLPRSSWADYDATLISKGGGIYPRTLKSIQISPQVAEVLGL DKGIKQLSPNVLISAILKAPVDLFWNGGIGTYVKASSETHADVGDRANNALRVNGLELRCKVVGEGGNLGLTQLG RIEAAQRGVLLNTDFIDNSAGVDTSDHEVNIKILLNDVVQAKTLSFDARNALLASMTDDVAQLVLWDNIRQNQAL SLMERMSVKRLGSKQHFIRTLERQGLLDRQIEFLPSDAELSARKARGLGLTRPELAVLLSYSKLVAFQQLLASDV PEDPYLSQELQRYFPEPLQKAYAHVMEQHRLKREIIATAVTNTTINRMGATFLMRMQEDTGRSIGEVAKAYTMSR ETLGVRALWAEIDALDGRIPESVQMDALEVIWRLQWSCVRWLLLRPGQMPDIAVVVERYRGAFNAIRPVAAVLPE MQRAAYEASLQDWKEKGLSQTLAQQLSELCFLGQAFDMIELAHTSKLHPVEVSKVHFCLGAALGLPWLFAHIDAL EVTGRWQAIARGVLRDELAAHQRSLSGHVLAMPGMSAEEKVDQWIGRDDSSLCFTLSMLAELNEQKTLDYPTLSV AVQRLGQLAAHGA Xylella fastidiosa NYSGXRC-6226c SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC871 ICEDB: T1935 GENBANK NP_438242.1 MTALSALIEQKLQSLGTILCQSFPELSPEKIHEAIQQNSNHPELPVYQLGYAIAMSDFVEKVLQKYPHLVKQWWEK SPCFADCTAYIERLNKELANVHDETALYQTLRQFRNIEMAKLSFCQSLNLATVEEIFVQLSQLAESLIIAARDWL YHQACAEIGTPMDEQGNPQQLYILGMGKLGGFELNFSSDIDLIFTYPSQGETSVENTNARRSVDNGKFFTRLGQR LISALDEFTSDGFVYRTDMRLRPFGDSGVLVLSFSAMEQYYQDQGRDWERYAMIKGRVLGAQTKDPNVSKLKKML RPFVYRRYIDFSVIQSLREMKGKIEREVRRRGLKDNIKLGAGGIREVEFIVQVFQLIRGGREINLQQHSLLKILP EITKLRLITEQQFHDLRESYIFLRRVENILQAINDQQTQTLPTDEIDQIRLVEACKTFTCLNENNQTIEKHYPIE NWDDFYRTLQQKQEKVRAVFTQLIGDEQDESSQTDSQWQDFLEADFEDIEQTLLESSVSENNIDEVLEKLAQFKD GLNHRVIGSRGRDVLSHLMPTVLALIFEQENYRTLLPRILNIIEKISSRTTYLELLLENPRALQQVIELCAQSQL ISEQLAHYPILLDELLNTEALRHPLPFTQYPAELHQYLLRLPPDDEEQLIDALRQFKQATLLKVAAADILGALPV MKVSDHLTYLAEAIIEVVVNLAWKQVSSRFGVPEHLQNNEKGFLVIGYGKLGGIELGYKSDLDLVFLYDAVESQT TGGKKVIDSNQFYLRLAQKIVSIFSINTSAGVLYEADMRLRPSGDAGLIGCSLSAFSHYQLNDAWTWEKQALVRA RPVFGESSLKAKFEHIRQQVLSASRDIEQLKQDVVEMRKKMFAHLSHSKHSEFNLKTDRGGITDIEFIAQYLMLA NAPKKPQLTKWSDNVRIFDDMAEAKIISQTDCDTLKQCYVDLRNTIHHLNLLGKSSVVEDSEFVKERSFIQAFWD RLFVS Haemophilus influenzae NYSGXRC-6227a SGX Pharmaceuticals 2004-01-19 active Selected EC2623 MNTISSLETTDLPAAYHIEQRAHAFPWSEKTFASNQGERYLNFQLTQNGKMAAFAITQVVLDEATLFNIAVDPDYQ RQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNEATIRRNYYPTTDGREDAIIMRCQSVCNTR WNNEVGLDFL Escherichia coli NYSGXRC-6227b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2623 MIEIKRIQQQPDLAQDIYAVMAAVYPVSPWTLEQIQADLSQDQTWYALAYDGAEVIGFLTVQETLFEAEVLQIAVK GAYQGQGIASALFAQLPTDKEIFLEVRQSNQRAQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG Streptococcus pneumoniae NYSGXRC-6227c SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2623 MFPRKELLKDGSLLLIREASIWDARRIVEYLKEVTSETDFLITRPDEVYDVSTERNYIRMYRSNPGKLMIVGEINR EIVSLLTFTGFGRKRTKHVGEIGISVKKRYWNIGIGTRMITSAIEWARRNGFIRIQLEVLKSNERAISLYRKLGF ELEGIKRKAVRRDDGSFEDVLVMALLLD Thermotoga maritima NYSGXRC-6227d SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2623 MSQVQVDRALAGLIVRAPLPAGWRAERMSALDVAAVAAVEQAAFAFPWSRGNFEDSLKSGHLGIVLRDGGNQVAGY LILMPVVDEMHLLNVTVAPAWQRQGLGRWLLRAAQALTLAHGFASLLLEVRPSNAGAIALYRRVGFAEIGRRKRY YPAENNTREDALVMRIACEAGGVEAA Ralstonia solanacearum NYSGXRC-6227e SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC2623 GENBANK NP_438183.1 MSIISQIEACDFERLYEIEQQAHLVPWSFGTLKNNQGERYLNLKLIENNQIIGFAICQTVLDEATLFNIAILPTYQ GCGFGKLLLGKLIFQLKEKGVQTLWLEVRESNSARFLYEKIGFNEVDIRKNYYPKPSGGRENAVVMACYL Haemophilus influenzae NYSGXRC-6227f SGX Pharmaceuticals 2004-08-02 active Selected Cloned EC2623 MNTISILSTTDLPAAWQIEQRAHAFPWSEKTFFGNQGERYLNFKLTADDRMAAFAITQVVLDEATLFNIAVDPDFQ RRGLGRMLLEHLIDELEKRGVVTLWLEVRASNAAAIALYESLGFNEATIRRNYYPTAQGHEDAIIMALPISM Salmonella typhi NYSGXRC-6227g SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC2623 VSAVGDKPNRDVCRGVTAVQRGDPDVWVRQATRADLLAIVRIEQSVFSHPWPYAAFERQLDTAGFLVAAEQSGLDS VAGYVVGDTIPGHGRPLGHIKDIAVRSTRQGDGIGRLLLSRGVAALAGQGAHTVKLEVRESNEVARHLYEEFGFE YIRRLPEYYADGEDAGVMAVRLADRDGF Halobacterium sp. NRC-1 NYSGXRC-6227h SGX Pharmaceuticals 2004-07-07 active Selected Cloned Expressed Soluble Purified EC2623 ICEDB: T1919 GENBANK NP_465600.1 VSLEEALLFREATVTDLKSIMNVENAAFTVPWTEAAFRNEFIINQYAYYLLAIYKEQVVGYAGVWLVLDEGHITNI AIHPDYQGNHYGEALLREMIRVAKERGVVRMTLEVRVSNDVAQGLYKKLGFQDGAIRKNYYPDTKEDALVMWVDL Listeria monocytogenes NYSGXRC-6228a SGX Pharmaceuticals 2004-07-02 active Selected Cloned Expressed Soluble Purified EC1728 ICEDB: T1920 GENBANK NP_289010.1 MIIERCCELALRAPARVVFPDALDQRVLKAAQYLHQQGLATPILVANPFELRQFALSHGVAMDGLQVIDPHGNLAM REEFAHRWLARAGEKTPPDALEKLTDPLMFAAAMVSAGKADVCIAGNLSSTANVLRAGLRIIGLQPGCKTLSSIF LMLPQYSGPALGFADCSVVPQPTAAQLADIALASAETWRAITGEEPRVAMLSFSSNGSARHPCVANVQQATEIVR ERAPKLVVDGELQFDAAFVPEVAAQKAPASPLQGKANVMVFPSLEAGNIGYKIAQRLGGYRAVGPLIQGLAAPMH DLSRGCSVQEIIELALVAAVPRQTEVNRESSLQTLVE Escherichia coli O157:H7 NYSGXRC-6228b SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC1728 GENBANK NP_357249.1 MSDTTKTASTRTSVTDQEALDFHAQGRPGKLEITPTKPMATQRDLSLAYSPGVAVPVKAIAENPATAYDYTTRGNM VAVISNGTAILGLGNLGALASKPVMEGKSVLFKRFADVDSIDLEVDTEDADEFINCVRYLGPSFGGINLEDIKAP ECFIIESRLRELMDIPVFHDDQHGTAIIAAAGLINAIELTGRDFKTTKLVCNGAGAAAIACMDLIKAMGFNPENI TLCDTKGVIYQGRTEGMNQWKSAHAVKTDRRTLTEAMNGADVVFGLSQKGAFTEEMIRSMAPKPIIFAMANPDPE ITPEEVSRIRDDAIMATGRSDYPNQVNNVLGFPYIFRGALDVRARQINDAMKIAAAQALADLAREDVPDDVAAAY QGNRPRFGSQYIIPVPFDPRLISAIPVAVAKAAIETGVAQREIPDLDAYARELSARRDPMASTTQRLYERVRRSP KRVVFAEAEEEQVMRAAISFTAQGLGTAILLGRDDIIKANAERAGIDLDRANIEITNARLSSRVDAYVDYLYARL QRGGFLLRDVQRLIHNDRNHFAACMVAMGDADAVVTGVTRNYSTALEDIRRCINTKPGHRVIGVSLVVSRNRTVF VADTAVHDMPNAEDLADIAEEAAHLARRFGYEPRVAMLAYSTFGQPVGERSDKVREAVKILDKRNVNFEVDGEMS ADVALNHQRMQSQYPFARLSGAANVLVMPAIHSASISTKMLQELGGATVIGPLLVGLDKSVQITSMGAKDSDIVN MAAIAAYNAGR Agrobacterium tumefaciens NYSGXRC-6228c SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC1728 MIIERARELAVRAPARVVFPDALDERVLKAAHYLQQCGLARPVLVASPFALRQFALSHRMAMDGIQVIDPHSNLSM RQRFAQRWLARAGEKTPPDAVEKLSDPLMFAAAMVSAGEADVCIAGNLSSTANVLRAGLRVIGLQPGCKTLSSIF LMLPQYAGPALGFADCSVVPQPTAAQLADIAIASADTWRAITGEEPRVAMLSFSSNGSARHPNVANVQQATEFVR ERAPQLLVDGELQFDAAFVPEVAAQKAPDSPLQGRANVMIFPSLEAGNIGYKIAQRLGGYRAVGPLIQGLAAPLH DLSRGCSVQEIIELALVAAVPRQADVSRERSLHTLVE Salmonella typhi NYSGXRC-6229a SGX Pharmaceuticals 2004-12-13 active Selected Cloned Expressed EC2213 GENBANK NP_010753.1 MSELHALLTFPERPISQSYYVPKLQHFLKSGIPATYTLEQVAAFEHEEKNRNGDKEFRESTDDNKTSNTTPLHVLA RSLPLDIKDEELQVVMDMMNILFEYGAGWNFIDYEDKTVGDLFLERNQSRESPLYRRLVEAGVSAELLLRKLNGG DVEFLDTDELIGIEPEESVQTAVDGQKEESVGSDDDATAANQQVYLKTELEYKDDALITKENKDGVMMDWETKIM ELASETLFPDPEATNSATILNIGFGMGIIDTFIQARKPYRHYICEAHPDVLAKMKMDGWYEKDNVVILEGRWQDT LNNLLDKGEVFFDGIYYDTFSEHYQDILDLYDVVVGLIKPEGVFSFFNGLGADRSLCYDVYKEIVEIDVATYGMK CDYTRYSLDEQLPDWNDVKRSYFNCNYYYHPRITFA Saccharomyces cerevisiae NYSGXRC-6229b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2213 MQPNEQPGTGPADTTLEQQDTAAAEVGHPRRIRSFVRRAGRTSTGQQRAIDELGPRFLLPYAAAPLDWEAAFGRTG ARRIFEIGFGMGETSAHIAQLRPDDDFLGVEVHEPGVGALLKLIGERGIGNVRIVSHDAVEVLAQMIPEGTLDGI HVFFPDPWHKKRHNKRRLIQGPFVARLAAHLRPGGYLHCATDWEEYAHQMLEVLSAEPLLENTADGFAPRPDYRP VTKFEKRGLRLGHGVWDVVFRKRAA Ralstonia solanacearum NYSGXRC-6229c SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2213 VMLYFITFREARVLLKSRDLALINVDLMKTGKKIRVRVSKDYVEFPDGSRVKKEIIKRIAEDEGNVYFVRDGEVFK AAIAGEHFYKLVPTIPPTIEINGIRMHRTKGTDPLKDTIAKVNTVKPREGEVVLDTCMGLGYTAIESAKRGARVI TIEKDPNVIELAKINPWSRELFESPKIKILQGDSFDLIKKFEDESFDVIIHDPPRFSLAGELYSEEFYMEMFRVL KPGGRLFHYVGNPGKRYRGLDLQKGVMERLRRVGFMKVRRVQEALGVFALKPSLE Pyrococcus horikoshii NYSGXRC-6230a SGX Pharmaceuticals 2004-05-17 active Selected EC2162 VSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSH LYSFSFEPKADWKHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGREYVAQFLISG AGALHIPSFPEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPR TNEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVKDRELRRKLTPRYRI GCKRILNSSTYYPAVADPKTELITDRIDRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGE DLVDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGVQALAPTREAQDR FNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN Mycobacterium tuberculosis NYSGXRC-6230b SGX Pharmaceuticals 2004-07-15 active Selected Cloned Expressed Soluble Purified EC2162 ICEDB: T1902 GENBANK NP_420607.1 MTASQQPTASQDPTRIDALVIGAGFGGMYAVHKLSGMGLSVQGFEAGGDVGGVWYWNRYPGARCDLMSLDYCYSFS PDIEQEWTWSEQFAAQSEILAYANFVADRLDLRRHFLFETWVTGAAYDEAANVWRVTVDDGRVFEATYCVMASGP LSIPKGVPFDGADDFKGEILLAAKWPHTPVSFEGKRVGLVGTGSTGIQIVPEVAKTAGALTVFQRTPSFTLPMRN VTLEPDYVAELKRNYAGIRQVARNSPLGGVRPQSTRPFFSVTPEQRRALMEDSWARGGLSFLGTFSDLLVNPEAN EQVAEFVRSKISEVVTDPVTAEKLKPRGYPIFARRPCLDTHYYETFNLPHVKLHDCLESPIVKITPAGLLTETGE VELDVLIFATGYDGLTGALLNFDVVGRGGLQLRDKWRDGAKSHLGLMIASFPNLFLVCGPNGPAALANIITLDQQ NIDWIADAITHMRQEGLATIEPTEGAEQGWMDMVYGMAELTLVSKANTWYVGGNISGKPRGLSMYTGGFQRYSEA CRLAAEKGYEDFVFEKAATKQGARSPETVG Caulobacter crescentus NYSGXRC-6231a SGX Pharmaceuticals 2004-11-29 active Selected EC3878 ILTLERRGIMNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSSK GHSKLIKGTLSQNKKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQ VVGTYSEARHFGFVIPDDKRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILS IIYQHGIEIEFPDEVLQEAEAVPDHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIAD VSYYVTEDSALDKEAYDRATSVYLVDRVIPMIPHRLSNGICSLNPHVDRLTLSCRMEIDASGRVVKHEIFDSVIH SDYRMTYDAVNQIITEKDPNIREQYKEITPMLDLAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEVGIPTDVQLR QRGEGERLIESFMLIANETVAEHFSKLNVPFIYRVHEQPKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQE EVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFTSPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRW EDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVKSHNLTSGIVHWNWPNNDRKVWVHICEI Staphylococcus aureus NYSGXRC-6231b SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3878 MKVLTDLQKRIFAIVKKENGKPIPPGIVVRMMENQAGFPGKQQVYRAIDDLLEHIFRKSGGATNQLLINYELADPV LDQKFQGILNLGNKNTGFVRPLDDDKTVYYIHFSNLAGALDGDLVEFCPLDKPQVGDKFDAAVLKIVKRSRVLYA GNFLIEYSDFGQEFRIVADNPRFYLTPIVNKASVPAELESNTKVAFQIDEYDPANNLCKVSIQQILGNNDEPLIN LKAIMLDHSIVFEDNDVVEQQAAKLQFDEKEQSKPYRKDLTELAFVTIDPATSKDLDDAIYVKRTDKGFVLYVAI ADVAYYVQRNSELDIEARHKTSSIYLPGYYVVPMLPERLSNELCSLNPNEKRYVVVCELNFDHEARLNFSEVYPA TIVSQRRFAYSEVNDLEDSDALKDESATVLESLKAGFTLSELIAEQRKKKGTIDLSHSETEVVVDQNYYPIEIRF LTHGKAETMIENLMVVANEAVATLTNHKVHLPYRVHPRPSKKKLQMLLENIVELKITQPNFVLDTVTSTQIAAWL KENKDNPSYDIFVILLLRTLGKAFYIVNPLIHFSIGSHHYTHFTSPIRRYADLTVHRLLWMNLFTPERFTDTERE QLNAELEQICETINDTEIKINGCERTANDYLTTLYLSKQVGQTFHGFISAITSFGIFMRMDENNFDGLIKITSIP EDFFVFEKDRMVLRGKRTNKVFRIGDRLTAKLTEIDTVQKRAILTLV Mycoplasma pneumoniae NYSGXRC-6231c SGX Pharmaceuticals 2004-06-14 active Selected Cloned Expressed EC3878 GENBANK NP_281814.1 VKEFLNSLSYGISSHEVNNEFKQIFRELLTNHIIKEHKNKYYLNNGFAFGVLDISSKGTGFLQCFDESFKKDLLIE NKNLKGANYKDIVAVKLLPLKKKRPSAKVILVLKRANETSLMITKRYGEAVLGMNIKTGLSTALKASQKSLKALP LGTILKIENENNNIIEVLGHIDDESVDEKISLALFNKNNEFSDACIKEALANGDSVDASMYENRMDLRALPFCTI DPIHAKDFDDAIYFDTQKREIYVAIADVSEYVYAYSAIDKEARNRGFSIYFPHIAIPMLPRPLSENICSLKPHLD RLAYCFKITLNHENKVIKEELFEGIINSKRRFNYDEVDEILIQKPDLKELSWLYELFEITKNLRKMRLKNAFEFR TEELRMNLDENLSLKSTVFEKDTPSHNLIEDCMLLANKAAAKLIDIGVFRNHLSADVRKIDKLLNELRELGIDVN FKPNLPELIRDIQALADELNLRAEVDKLIIKAQKKAEYSSVNAGHFGLGFDKYSHFTSPIRRYSDLILHRLLKAK QKNDEKLFNYLLLNIESTCENLSTLEREADKVAFDFMDRKFARWAAKNIGKKFKALVVQNDGVCIAKLDDEIKGA DIILYDTRVNLLENVEVQIMEADIVMAKIYAKITQRLIKEENV Campylobacter jejuni NYSGXRC-6231d SGX Pharmaceuticals 2004-07-06 active Selected EC3878 MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFR ANKAGFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDK PKYAGYIRSKNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPIRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDI VSEFPAEVLAEANAISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTE GSALDKEAIARGTSVYVTDRVVPMLPERLSNGICSLNPNIDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTY STVNDMIAGDEEALQEFASIADDVTLMVALHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERM IESFMLAANECVAEHFAKAKLPFIYRIHEEPKAEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGA EVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHFTSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSS SQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVVKFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQG EKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKMSDKASRRDRRKSSKSSKGTKKKEPKEVAKAK TKGKTKKGSKKPFYKEQAKKKSRKRS Streptococcus pyogenes NYSGXRC-6231e SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3878 MTKQTIKEQILHFMESQKKKSFSMEEIAQGLNLEKSSDFKILVQTIAQMEREKSVSFNKKGKVLLPMKDLLIEGTF RANERGFGFVTIDPEEPDVYIPKEATNFAMDGDTVLIDVIQHADPFSDRGAEGKVKEIKERAVSQVVGEFVAYSE EEMAEMGLYGYMIPKDKKLNQYTVSIAPEGIKPVDGSIVIAEITYYPDQEYPTSMEGLVKQVIGHKNDPGMDILS IVVAHGIPTAFPDEVLAEADQVPETIAESDLVGRRDLRDQLIVTIDGEDAKDLDDAVTVQKLANGNFFLGVHIAD VSYYVTEGSQLDMEAYERGTSVYLTDRVVPMIPQRLSNGICSLNPHVPRLTMSCEMEITPEGEVISHEIFQSVIQ TTERMTYTAVNEILEEQKPETLERYKELVPMFKEMGELHHILEEMRMRRGAISFEDREAKVLVDENGHPKDILLR TRGVGERLIESFMLAANETVARHYHDLKLPFIYRIHEQPKEEKMQRFFDFAAVLGILVKGTKENISPKDLQKVLE QVENKPEEVVINTMLLRSMQQAKYSEDNYGHYGLAAEYYTHFTSPIRRYPDLIVHRLIRSYSQDQSEKNQEKWNE ALPEIANHSSSMERRAVDAEREVDAMKKAEFMVDKVGETYDGIISSVTKFGIFVELPNTIEGLIHVNNLKQDYFH FIENHMALVGERTGMTLKIGQKVQIRVEKADPETREVDFELISAEEVAPVEGPKGRKKGKANSSTRSNNQRRNKK DESFDGKKKKNKKKGKGKKQPFYKEAMKQKNKKGKKKK Enterococcus faecalis NYSGXRC-6231f SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3878 GENBANK NP_253624.1 MADWQNLDPEAAREAEKYENPIPSRELILAHLSERGAPATRSQLLDEFGLAGEEPEEALRRRLRAMERDGQLIYTR RGAYAPVDKLDLIRGRISGHRDGFGFLIPDDGSDDLFLSPTQMRLVFDGDRALARVSGHDRRGRREGQLVEVIER AHEIVVGRYFEESGIGVVVADNPKIQQEVLIPPGKAGKARHNQFVQVRIEQWPSIHRQAQGEIVEVLGDYMAPGM EIEVALRSYDIPHVWPAAVEKEAAKLKPEVAEKDKEKRVDLRQVPFVTIDGEDARDFDDAVYAEAKRGGGWRLFV AIADVSHYVKVGSALDEEAARRGNSVYFPERVIPMLPEVLSNGLCSLNPLVDRLAMVCEMTLSKAGKLTGYQFYE AVIHSHARLTYTKVSQLLEHPDSVEAENLRQQLPGVVPHLQQLYALYKALLAGRHVRGAIDFETQETRIVFGADR KISEIRPTQRNDAHRLIEECMLCANVATARFLQKHAIPALYRVHDGPPQEKLNNLRQFLGELGLSLGRGKAAPTP GDYQELLEKIHDRADFRLIQTVMLRSLSQAVYSPDNNGHFGLNYDAYTHFTSPIRRYPDLLVHRAIRSVIRSKAE TPHVQRAGAASMPKARIYPYDELRLDQLGEQCSMTERRADEATRDVTNWLKCEYMRERVGETFPGVITAVTGFGL FVELTDIFVEGLVHVTALPGDYYHFDAVHHRLSGERTGRSFRLGDTTEVVVARVDLDERKIDFELAGNVLSAPIG RKKRNGDKSANAGKAPKGRKGASVPEVDLEPALASPDAAVVPRRKAGKVQALPPVAPELLAQAAEMLGNTDVRKS REVKQALLAEARVGGKDKGGKKGKVVPAGKSAKGKAKDGKPAAAAKPGKPTKHRKGPSKPKADNAPAATGARKRK AKS Pseudomonas aeruginosa NYSGXRC-6231g SGX Pharmaceuticals 2004-07-06 active Selected Cloned Expressed Soluble EC3878 GENBANK NP_244420.1 MNEQKAQQLLMFFREQAEKPLSVNELEEALNLEDAQEFKELVQVLNEMEEKGLLVRTRSNRYGVPEKMNLLRGVVQ GHAKGFAFVIPEEEGHSDVYVSHVDLESAMNGDRVIVRLHPHSTGTRPEGKVIRILERGVSEVIGTYVDHQTYGL VVADDKRIPNDILIVNPEAQGLVDGHKVIVKITKYPEGRMSAEGEVISILGHKNDPGMDILSIIYKYGIPQAFPE EVLQQAQNIPDEIDAGEIKNRRDLRDEPLVTIDGADAKDLDDAVHVSRLPNGNFKLGVHIADVSYYVKEKSPIDL EAAERGTSVYLVDRVIPMIPHRLSNGICSLNPQVDRLTLSCEMEITRDGQVVNHEIFQSVIRTNERMTYHDVNKI LVEKEEELRNRYELLVPMFEDMEELAAILRKKRFGRGAIDFDFKEAKVLVDEEGKPSDVVIRERGVAEKLIEEFM LAANETVAEHFHWLKLPFMYRIHEDPDSEKLGRFLEFITNFGYVVRGTANTVHPRALQKLLEEVRGEPEEQVIST VMLRSMQQAKYDPTSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIREYLIKGNVDEETQEKWRERLPEIARHCSE MERRAVDAERETDDVKKAQFMEDKIGETFTGIISGVTNFGIFVELENTIEGLVHVSYLTDDYYRYDEKHYAMIGE RSGNVFRIGDEIEVRVINVNVEEASIDFEIVGMKPRKQRPDKSRPKVIEGGKRKKKENRGALALDGSKPKKKKKK KAFYENAPSAKRKKGKKRKR Bacillus halodurans NYSGXRC-6231h SGX Pharmaceuticals 2004-07-23 active Selected Cloned Expressed Soluble Purified EC3878 ICEDB: T1936 GENBANK EDV12811.1 MSLSTIICIGMAGSGKTTFMQRLNSHLRAEKTPPYVINLDPAVLRVPYGANIDIRDSIKYKKVMENYQLGPNGAIV TSLNLFSTKIDQVIRLVEQKKDKFQNCIIDTPGQIECFVWSASGAIITESFASSFPTVIAYIVDTPRNSSPTTFM SNMLYACSILYKTKLPMIVVFNKTDVCKADFAKEWMTDFESFQAAIKEDQDLNGDNGLGSGYMSSLVNSMSLMLE EFYSQLDVVGVSSFTGDGFDEFMQCVDKKVDEYDQYYKQEREKALNLKKKKEEMRKQKSLNGLMKDLGLNEKSSA AASDNDSIDAISDLEEDANDGLVDRDEDEGVEREYTFPGEERTKGEVNENSAPDLQRRYQEAMQQVGKTASSETA ENIAKYIRN Saccharomyces cerevisiae NYSGXRC-6231i SGX Pharmaceuticals 2005-05-05 active Selected Cloned Expressed Soluble EC3878 GENBANK NP_232227.1 MSDTTHLDPFADREADNYDNPIPSREYILEFLTQANVPMNRNDLFEALKLEGEEQYEGLRRRLRAMERDGQLVFTR RQCYALPEKLEMVKGYVIGHKDGHGWVRPEGSLNKEGDILLPHHQMRTLIHGDFVLVQPSGTDKRGRKEGRLVRI LEERNGQIVGRFFFEYGYSYVVPDDSRIHHDILIPNDLRAGARMGNVVVIEITDRGTRNRGMMGKVVEVLGENMA PGMETQIAIRTHQIPHEWPAEVEQQVAGLTEEVPEEAKQGRVDLRALPLVTIDGEDARDFDDAVYCEAKKGGGWR LWVAIADVSYYVRPDTALDKEAINRGNSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTVSETGKLSGYK HYEAVMNSHARLTYTKVHEILEGDEELRERYKALVPHLEELHKMYQVLKSARDERGAIEFETVETKFIFNAQRKI ESIEPVVRNDAHKLIEECMILANIASASLVEKAKEAALYRVHEPPGEERLTGFRDFLGELGLDLSGGLEPSPTDY ANLMKQIGERPDKELIQTMLLRSMKQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKQEGRNQ DRWTPTGGYHYSFDDMDFYGEQCSMTERRADDATREVSDWLKCEYMQDHVGEELEGVVANVTSFGFFVRLTELHI DGLVHISTLANDYYHYDPIGQRLVGESFGAIYRLGDAVKVKVLAVNLDDRQIDFELVETSRKLRGQGKTAKKRAD EARAKAQGKKEAATKGACGKSPTKSELKPQVEATRRPDSEGRSKPKKTKAPKKRKDQARKKSGKVRDKTK Vibrio cholerae NYSGXRC-6231j SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3878 MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHK NGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKY AGYIRSKNQKISQPIYVKKSALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSE FPEAVVKEAESVPDAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSA LDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDV NDILAGDEEKRKEYHKIVSSIELMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIES FMLMANETVAEHFSKLDLPFIYRIHEEPKAEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVL SMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRE RRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSG ITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSRSGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQ KDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK Streptococcus pneumoniae NYSGXRC-6231k SGX Pharmaceuticals 2004-07-06 active Selected EC3878 MEFSIATLLANFTDDKLVARKVLEKKLGCEDEDSLEKLHIALEVLERIGVLAKERGKYRRISEEGMIEAKLRCSSK GFCFAIQDVEGAEDIYIRESHLSNTWNGDRVLVRVLKEGSRRRSPEGEVKLILERSNHTLLARIKQVEGGFRAVP LDDRLLFELKIQANKLKLEEAIDHLAHVEVLRYPLAQYPPVGRVVQILGSDAEAAADIDLVTCKHDLSRNFPESI LDAAAKLPKRLLKADLKNKLDLRNLFTFTITGINSDTKVIENAISLEKTIAGNWQLGFHIADVSHYVQPDEPLDR EAIKRGRSVYLGDLVLSMLPDTVADRASFVTGSDRLALSFLITISSQLGEVLEWEIQPSVINVDNNVSKQQAEAI LQGAATKKDSPQIIERLQNLTTIGQAIKESRLARGSLQLNLPSNQNPYYDEGSLGAVLVNDSPVRSLLMELVLLV NELIATHLSALGIPAIWRTQGTPDSEDVQEMLKLAINLGVELALEPEVDIEPLDYQQLTRAFAESPSEQVLTYLL QDTLKPAVYSTTKASHFGLALLQYTHFTAPLRRYPDLLMQRVYYQLLEHGRDRRNTRVKERVNLRHSSSHSEINW NVLAPELQQEMQSDLTRVIIQINDREKEVQEAEADLAGLQKAQLMKQRIGQVFQGVITGVQSYGFFVEIEVPAAE AATNPGVPLRVEGLVHVSSLKDDWYEYRARQQALFGRKNRASYRLGDRVSVQVKSVDYYRQQIDLVTVGSDGLVK NLGVGNVNGDISDIYLPNDMESDDLDSYADEE Nostoc sp. NYSGXRC-6231l SGX Pharmaceuticals 2004-05-17 active Selected Cloned EC3878 MSDSEPAQGSIEDQGPVEISPELARQLENKRDDLFEKFDLHDEFPPDVVAEAEARTEDVQAEIQAEIEDRADMRPL PTWTVDPVDAQDFDDAISVLERDDEYVLWVHIADVTHYVHPDSEMWAEAIDRANTVYLPGYTMHMLPPVLAETVC SLVPGEDRLAHTVEMHLDKDDLSYQTIEIYKSVIHSDERLTYKDAEQRLDDETAPLHDDLSLVFDLADQMHEQRK AEGSLVLNPRRDRAHTIIEESMLKANKAVTHELMWNRGVEAVYRVHPQPSPEEWDDALQEIQELNGVSIPGDAWD DPRKAVNATLEQAPERQLGKIQWAVMKVMPRARYMNDPFGGHHALNFEIYGHFTSPIRRMSDLVNHWIVYQNDVP ETLISLCDRASDKQQAGETAEREYRDFLEEVGLDPDAVNNRGVTVVDSPTTSS Halobacterium sp. NRC-1 NYSGXRC-6231m SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3878 MSSIRKKDVERFILSDDYKPMVLKELYKKFRAKTREQRKKVREVVKKLEKEGRIFRDSRGRYRKLGEDLKVGTIEF TRSGYVAFVITDDFEEIAVPVEDTKYAMHKDRVVVEITGTWRGLPRGRVVRVLERGLKRVVGVFDHKGTFGFVVP DDPKIAYDFYVAPENIDGAKPNQKVIAEILKYPSPGKNPEAKVVKVLGDLDDPSIDLPSVIVKHDLPEPGEFPEE VIREANAIPARVRKKDLVGRKDLRDKVIVTIDGEDAKDFDDAISVEKLPNGNYLLGVHIADVSHYVKEGSALDQE AFKRGTSVYLIDTVIPMLPFRLSNGICSLVEGKDRLTMSVEMEIDRDGRVVRYDVYPSVIKSKKRMIYERVNEFL EDPSSMKEYEPFKDLIYNAVELAEILREARRKRGAILDIESDEVKVILDENGQVVDIVPRKRGIAEKLIEEFMIR ANETVAEIFDHAGLPFMYRVHEEPDPETIFQLKNYLEAMGIRAKFSHKIHPGMLQKLLEKVKDHPLRSSVERLLV RSMKRAMYSAVNIGHFGLASYAYTHFTSPIRRYPDLVVHRLLKLYLEQNGYFTPEQIEKFSKVLPKIAKHCSRRE RVADEAEWDLVAMKKVEYIARHIGEVFNVVVTNITKFGLFVEIPEKSISGLVHISTLDDYYYYDETRNMLIGKRK GKVFRLGDVLKAKVVRADKIRGEIDFVLVEEDEE Thermotoga maritima NYSGXRC-6231n SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed Soluble EC3878 GENBANK NP_391241.1 MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRSDRYGIPEKMNLIKGKI SAHAKGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFG FVIPDDKKITSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFP ADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPID KEALERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNK ILVDDDEELKQKYEPLVPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEEF MLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVIS TVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTS SMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIG ERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTNTPVSPAPSEEK GEWFTKPKKKKKKRGFQNAPKQKRKKKK Bacillus subtilis NYSGXRC-6231o SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified EC3878 ICEDB: T2209 GENBANK NP_465972.1 VEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADNFKLMVKALVKLEDSGTIVRSRKNRYALPEKMDLVKGTF RAHERGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRKGDNLAEGTIKKIVERKTTQIVGTYMEDLAGT PIVMPDDKRLFGEVEIDLEDGLKPVDGHKVIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGF PEEVMEQVSKAPDLVDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSPL DIEAQERGTSVYLVDRVIPMLPHKLSNGICSLNPQVDRFTMSCEMEIDQEGHVVNHEIFESIIKTTERMTYTDVN DILVEKDEALREKYAPIVPMLEAMQNLAEILRRKREKRGAIDFDFKEARVVVDEDGHPEAVVMRERSAGEHLIEE FMLAANETVAEHFHWMDVPFIYRIHEDPKEDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVV STVMLRSMQQAKYDTVSAGHFGLSTDFYTHFTSPIRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEHS SKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVTNFGLFIELPTTIEGLVHVSAMKGDYFKFHQNQLAMI GERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDKQKRQREKPIDKTRNFKSSSKNNRNKRRTGKS EDVKPKTERKDDEWYTKPKKKKKKKPFYQGVAKESPKKKKRR Listeria monocytogenes NYSGXRC-6232a SGX Pharmaceuticals 2004-07-09 active Selected Cloned Expressed Soluble EC1133 GENBANK CAA68815.1 MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAEL LDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEG YGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTI PVIGFPSPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPR LDDRLCSFAAMIALICYAKDVDTEESELFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKAVDLHTVW ANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSR SGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL Saccharomyces cerevisiae NYSGXRC-6233a SGX Pharmaceuticals 2004-09-14 active Selected Cloned EC331 GENBANK AAB98859.1 LFNNKYIKIMRWEIMFKFDREQMVVEIAGRKIGGQPGEYPTALAGTIFYARHKIVEDERKGIFDKAAAEDLINKQA EMEDITGNPALVQVFGGTPEALVNYIDFVAEVWDGPMLLDSTSGEARMAAAKRATEAGYAKQCIYNSINVSIDEQ EYQVLVESDLEASIVLCFDPMDPTVEGKINVLTNGGKTADKGMLELAEKAGIKYPLIDTAVTPLGNGAGAAVRAS FAVKALFGYPVGSGIHNIPSAWDWLREFRKQLREAGEREKAKDIHHVCDVGANLVQVMASGDFVLYGPIDNAYMT FPAVAMVDAIIAEAAKELGIEPIDTHPFKKLV Methanococcus jannaschii NYSGXRC-6233b SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC331 GENBANK AAB91219.1 VVLMFRFENQKVFEIGGVKIGGEVGENPTVLIGSIFYGKHKIVEDEKRGIFDREGAEALIREMEDLSDKTGNPGLL DVVGMSEEAMIKYIDFVADVTDSPFLIDSAIADIKLAGVKHADEVGLSDRVIYNSISPESKDAEIEALANSKVEA AVVLAYTYNVISSAARLQALEKAMAKVEKAGITKPIVDTFVMDVPSLPAAAKAAIDIKRKYGLPTGSGAHNAIGS WKGFKNMFGKEAEKAATIVAVTMQIILGSDFVLYGPIEDCREVFPAMYTIDTAYKYFRRTKDWIEMV Archaeoglobus fulgidus NYSGXRC-6234a SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC4966 IAISWAYFNGLKNVSPLLMEKASKRSLDVIKHLVKNWDPKTDLYSINIPLVESLSDDTKVYYAPIWENRWIPIFNG PHINLENSFAEIEDGNESSSISFNWAPKFGAHKDSIHYMDEYKDRTVLTDAEVIESEMISVTPMKATFKGVNHLL GELKLTEEENNLSKTNNLIVVSIDPMEYIYKPLTTPEKYLPQVEIVSNLPEFDNGGCEKEMKVFHYGDYEQLDMD KLMELPNNYFTNSYIYRKALIRKHFLSHTIQTYTAKNPESILKKAYLESFTIDLDYAEFLDDALDENWELRQELE NESQDKWWIVKPSMSDKGQGIRVFKTIEDLQAIFDSFDDEDSEAEESGNDDDADDVNGEFMDNNKVNISQLRHFI IQEYLTNPLLLASMDNRKFRIRCYVVCRGDLQVFVYDRMLALFAAKPFVPLDPYAYSVTDLKDLECHLTNTCLQS KKKDKDSSVLEFDSIEEIPNERKSNIKEQIHSITNDVFLAAVNVNRLNFQPLPNAFETYGVDFLIDSNYEVKLLE INAFPDFKQTGKDLKNLIDELFDDTVKYCVTPIFNENRNKTDDETDPNFVKVIDYTSNGW Saccharomyces cerevisiae NYSGXRC-6234b SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble EC4966 MSSTKKDIKVYVNYRDEYAEPKIISALKNSGKELTFTNSAKEANFQWAQYEDIDFDEVYKNPKTKLCCSYVIRKAL IRKEYLWRTVITYLAKHPDSILSKSVPEAYSLELDYAEFLDDSLMEAYELRQELEENATKNISEKQWYILKPSMC DRAQGIRLFSTIEELQAIFDSFDDEESESEEAGLEEKGDITVAFNNKIVISQIRNFLVQKYISKPLLLDHRKFHI RAYVLATGALSVYLFNEMLCLLARDKYKKPTPDPDLLFSHLSNTCLQGDNVEQSSIRDFWNTSIENKDDIFKSIL NIIGDVFEAAATTQGIHFQPLENCFEIFGVDFLVDCESQVYLLEVNSYPDFKQTGKNLSNIIENLFSAVVETAII PFFESSTKRNVDSKLTLAKKLQLFGFR Schizosaccharomyces pombe NYSGXRC-6235a SGX Pharmaceuticals 2004-01-20 active Selected EC967 MPQLNRQLHPQKLVPGCSTICIVFRLTKSFVDKIAIKRNLSYPTARTYSCSHNCSHRKWHDPTKVQLCTLMNIKSG GCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKRGRRGCKRNGSTRFCLGAAWRDMKGRKSAMKRIQEMVTKVNDM GLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIKNVQESGIKACTGGILGLGES EDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTIATARIVMPKAIIRLAAGRYT MKETEQFVCFMAGCNSIFTGKKMLTTIYNGWDEDKAMLAKWGLQPMEAFKYDRS Saccharomyces cerevisiae NYSGXRC-6235b SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC967 GENBANK NP_282811.1 MQIMLCAISNIASGNCSEDCKYCTQSAHVKTDIQKYRRKELSQIVLEAKMAKKNEALGFCLVTAGLGLDDEKLEYV CEAAKAVQKEVPNLLLIACNGMASVEQLKELKKAGIFSYNHNLESSKEFFPQICTTHTWESRFQTNLNAKEAGLM LCCGGIYGMGESEEDRLSFRKSLQELQPFSTPINFFIANENLKLQVPRLSADEALKIVRDTKEALPQSVVMVAGG REVVLRERQYEIFQAGAGAIVIGDYLTTKGEEPSQDIIKLKEMGFTFASECH Campylobacter jejuni NYSGXRC-6235c SGX Pharmaceuticals 2004-01-20 active Selected EC967 MTVSPVALRRKTECKPHPTARYWKKCDVEALFGLPFLDLIYQAAEIHRQNFNPREIQLSTLLSIKTGGCPEDCAYC PQSAHHNTNLGKEQMMDVDEIVEKAKIAKSRGASRFCMGAAWRGPKPKDVETVSAIIKAVKGLGMETCGTFGMLE EGMAEDLKEAGLDYYNHNLDTDPDRYNDIIHTRQHEDRMDTLGKVRNAGLKVCCGGIVGMNETRAERAGLIASLA NLDPQPESVPINRLVKVEGTPLADAEDLDWTEFVRTIAVARITMPQSYVRLSAGRSNMPEAMQAMCFMAGANSIF YGDKLLTTGNPDEDGDRILMEKLNLYPLQFEPEGEVAEVEKASGIKVDY Neisseria meningitidis NYSGXRC-6235d SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC967 GENBANK YP_001928250.1 MIQTIENRLINGGELTLEEALLLASSADKEALYEAAHRITRYFMGDKFDTCSIINAKSGNCPEDCKWCAQSRHYAA SIEKYGLLSAAVCAEQAAYNRRQGIGRFSLVASGRTASMNEIRQMAESYRAIKQRTDIKCCASLGLLSEEKLQIL FDNGVTTYHCNMETAPSFFPSLCSTHTQDEKLATIRAARRVGMRVCSGGIIGMGETMEQRIEFAFYLHSINVYSI PINILQPIPGTPLERTLPLSEEEYLTTVALFRLINPRAFLRFSGGRAQLSPAVQRKAIYIGINAAITGDLLTTTG SKAAEDMQLVRECGFQVTNDTDWEVSYDH Porphyromonas gingivalis NYSGXRC-6235e SGX Pharmaceuticals 2004-01-20 active Selected EC967 VEVRHNWTVAEVKALLDKPFMDLLFEAQQVHRLHHPHNHVQVSTLLSIKTGACPEDCKYCPQSAHYRTDVDKERLM EVERVLDAAQKAKNSGSTRFCMGAAWKNPKERDMPLLKEMIRGVKDMGLETCMTLGMLTPDQAQQLAQAGLDYYN HNLDTSPEFYGNIITTRTYQDRLDTLSHVRDAGMKICSGGIIGMGESTNDRAGLLVELANLPTHPESVPINMLVK VKGTPLEQVDDVEPFDFVRLIAVARIMMPKSAVRLSAGREKMNEQMQALCFMAGANSIFYGCKLLTTPNPAEDSD MLLFKKLGINREQVAQKPDEITENELLDRVVERVAARPTASDLFYDAAL Vibrio cholerae NYSGXRC-6235f SGX Pharmaceuticals 2004-01-20 active Selected EC967 MSVGRIRYDWHKAEIRAVYDTPLLELIYQAASVHRQFHNPKQIQVCKLISIKTGACPEDCSYCAQSSRYQTEVKPQ ALLDKQTVVEIAQNAKQKGVSRVCMGAAWREVRDNSQFDRVLEMVKDVTDMGLEVCCTLGMLTSEQAKKLETAGL YAYNHNLDTSSDYYSTIITTRTYGDRLNTIENVRQTNVTVCSGGILGLGESIDDRVAMLQTLATLNPHPESVPIN ILSQVEGTPLEDQPDVPVWDVVRMIATARIVMPTSDVRLSAGRARLSQVEQAFCFMAGANSIFSSDDNKMLTVTT PCPDYDADQEMLNLLGLEMRPPSQRPQPVVMGNS Nostoc sp. NYSGXRC-6236a SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble EC1101 GENBANK CAA29137.1 ADSSYYDEDYRPQYHFTPEANWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDE KGTIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNPVIPNPGKKDFRDPKV FWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSHGGVWECPDLFELPVDGNPNQKKWVMQVSVGNG AVSGGSGMQYFVGDFDGTHFKNENPPNKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWR SATSIPRELKLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKVSPGSAAEF GFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKPVNGKVKLRIFVDRSSVEVFGNDGKQ VITDIILPDRSSKGLELYAANGGVKVKSLTIHPLKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFIL SSASGSDFTYESDITIKDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNKK YHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES Bacillus subtilis NYSGXRC-6236b SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC1101 MLLQAFLFLLAGFAAKISASMTNETSDRPLVHFTPNKGWMNDPNGLWYDEKDAKWHLYFQYNPNDTVWGTPLFWGH ATSDDLTNWEDQPIAIAPKRNDSGAFSGSMVVDYNNTSGFFNDTIDPRQRCVAIWTYNTPESEEQYISYSLDGGY TFTEYQKNPVLAANSTQFRDPKVFWYEPSQKWIMTAAKSQDYKIEIYSSDDLKSWKLESAFANEGFLGYQYECPG LIEVPTEQDPSKSYWVMFISINPGAPAGGSFNQYFVGSFNGTHFEAFDNQSRVVDFGKDYYALQTFFNTDPTYGS ALGIAWASNWEYSAFVPTNPWRSSMSLVRKFSLNTEYQANPETELINLKAEPILNISNAGPWSRFATNTTLTKAN SYNVDLSNSTGTLEFELVYAVNTTQTISKSVFADLSLWFKGLEDPEEYLRMGFEVSASSFFLDRGNSKVKFVKEN PYFTNRMSVNNQPFKSENDLSYYKVYGLLDQNILELYFNDGDVVSTNTYFMTTGNALGSVNMTTGVDNLFYIDKF QVREVK Saccharomyces cerevisiae NYSGXRC-6236c SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1101 GENBANK NP_720557.1 MEEETVCKNWFMRKSGKSWIFGCAVFFVLGLATALPVAAEEISQTTAADTAVTEVRTEDSSQTSSQETAVTETTQS EGTASKQLTTPAVADQTTEPTDNEPISSSDGASSPYQVTDTTEPQQTLTPADSEPQAKADVQQAAAPKKEEINPV TNLEDMSHDTNGTWEVREDGIHSNAIGKGDSFLYSQSSGKNFVYATDVTFKQNSGAAALVFRSNNDSNNKNMYAV NVDIGGHKAKFWRWVDNKDIQLIDERDVVPTADNRYTLKVVAVNNWISYYVNDILMASTGDYVLQKADKGQNTVI PEGHFGLLNWNGDMVFQNTKFALLDDTTAPLIDNITVRSDRGNVEKQGQFFSEEPLHIQYVSNDASQVSLDIAKH NPAATVTVEDKTGRVYTDPSHLPVNVGANYFTVKSTVIDSFGRTVTLTYRINVHRRQNDEVYYNELYRDQYHYSV KDGWANDPNGLVYYNGVYHLFHQFYDDTKWGPMHWAHATSTDLIHWKEEPIAFYPDSNGYMFSGCVVVDEHNSSG LFKTAKGGLVAIITANGNGQRMELAYSEDEGKTWQKYDRIVADWSNDPLQNQDFRDPKVFHWNNQWFMVLAGGPL RIYSSNNLKDWKVESTYPDLHTECPDMYPIVANDGVLKWVLSRGGRFYKVGDFKQVDGKWTFIADDAYKDKDQVM NFGKDSYAAMTYYVHDFGTETRPTIPKLTEVNWMNTWEDYCNLVADTVGQDFNGTFNLNLDLGLINENGQYILTQ TPVKAYDSLRDVNTALHFKDVTVDANNTLLKDFKGDSYEIVSHFRPDEKTTKVGFNLRVGNGQATKVIYDLQTET LSIDRSQSGTILSAAFAKVNSQHVTKNADGSIDLHIYVDRASVEVFSKNNTVAGANQIFPNPEAVGASIIVEGGK AQADISVYQMKTIWTDKKDTAKPVAMNTTTAKELALQVGQSQDLQVYLAPASVRQDVEWTISDPSLVRTSQKGNV LHLTAVKKGKLTITAISKENPSLSKTFTISITLNNFKTNLKGLQSVTGKWYVDDETLYDSNTSSNDYYMASQKPG FKEYDYDIDLKYQRGLINLFVASGNIDPSQAYSVQFGDSETVRLYRFAGDTIAEANMGKRINDDQYHHIKVTKTK NSIIISVDGQEVMSHNFDQVDSYFNDAYVGLGLWDGAVEFQNFFVTDHATTPKPDSDPTPQPDAPEALAQERELI DPATGVRVILQKGELASIVRVKVSHIETNDAHTPAVLNAKDYDLFNITPIDKNEKVVAITKPATVLLPIDAGKVV DKVVYLPNTDKEENLPFTIVSLTDSNGKKQSYVRFTAEHFSEYGLVYQAENQTNLKSKEKQDNVAISYPLNLEQE VKVSSISRKYAANKTADVNSVQQTEPSVMSSSPKATLPDTGDHKTDLSQLGVLAMIGSFLVEIAGYFKKRKD Streptococcus mutans NYSGXRC-6237a SGX Pharmaceuticals 2004-07-15 active Selected Cloned Expressed Soluble Purified EC2351 ICEDB: T1921 GENBANK NP_251316.1 MSESAPTPRRERVIVGMSGGVDSSVSALLLLQQGYQVEGLFMKNWDEDDGTEYCTAREDLADAQAVCDRIGIKLHT ANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYALMLGADLIATGHYVRRRDRDGRTELLKGLDP NKDQSYFLHAVGGEQIARSLFPVGELEKPEVRAIAEKHGLATAKKKDSTGICFIGERRFTDFLKQYLPAQPGDIE TTEGKVIGRHSGLMYHTIGQRQGLGIGGLKEAGDDPWYVLGKDLQRNVLLVGQGNDHPLLFSRALLASRIYWVNP VELERPRRLRAKVRYRQSDQDCVLEKTAEGYRAVFDEPQRAVTPGQSVVFYDGDVCLGGGVIETAEAWDFGGRP Pseudomonas aeruginosa NYSGXRC-6238a SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed EC997 GENBANK NP_011910.1 MAEFSADLCLFDLDGTIVSTTVAAEKAWTKLCYEYGVDPSELFKHSHGARTQEVLRRFFPKLDDTDNKGVLALEKD IAHSYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGSPYLAFSWFETILKNVGKPKVFITGFDVKNGK PDPEGYSRARDLLRQDLQLTGKQDLKYVVFEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVS VVKNNENGIVIQVNNPLTRA Saccharomyces cerevisiae NYSGXRC-6239a SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC1190 ICEDB: T1937 GENBANK NP_417536.1 MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKESGLTAKDIDAV AYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVCGGHTQLISVTGIGQY ELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNG TDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDN GAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA Escherichia coli NYSGXRC-6239b SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC1190 GENBANK NP_355588.2 LMPPFLRILGIETSCDETAASIVVRHADGRGEIVSDVVLSQLEEHSAYGGVVPEIAARAHVEALDTLVEEALDQAG VKLADVDAIAATSGPGLIGGLLVGLMTGKAIAKAAGKPLYAINHLEGHALTARLTDGLSFPYLMLLVSGGHTQLV LVRGVGEYERWGTTIDDALGEAFDKTAKLLGLPYPGGPAVENAAAKGDPDRFPLPRPMVGEARLDFSFSGLKTAV RQAATAIAPLSEQDIADICASFQKAVSRTLKDRIGRGLARFKVEFPHINGEPALVVAGGVAANQEIRQTLQALCD THGFRFVAPPHRLCTDNAAMIAWAGLERMAEGRQADALEVAPRSRWPLDGSAETLIGFGKRGAKA Agrobacterium tumefaciens NYSGXRC-6239c SGX Pharmaceuticals 2004-09-14 active Selected Cloned EC1190 GENBANK NP_109747.1 MEQPLCILGIETTCDDTSIGVITESKVQAHIVLSSAKLHAQTGGVVPEVAARSHEQNLLKALQQSGVVLEQITHIA YAANPGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALIDQDINQLKLPALGLVVSGGHTAIYLIKSLFD LELIAETSDDAIGEVYDKVGRAMGFPYPAGPQLDSLFQPELVKSHYFFRPSTKTKFSYSGLKSQCFTKIKQLRER KGFNPQTHDWNEFASNFQATIIDHYINHVKDAIQQHQPQMLLLGGGVSANKYLREQVTQLQLPYLIAPLKYTSDN GAMIGFYANLLINGKNN Mycoplasma pneumoniae NYSGXRC-6239d SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC1190 LRVGATLARAIALKYNKKLVPVNHGIGHIEIGYLTTEARDPLILYLSGGNTIITTFYKGRFRVFGETLDIALGNMM DVFVREVSLAPPYIINGIHVIDICAEKGNKLLKLPYVVKGQDMSFSGLLTAALRVVGKEKLEDICYSVREIAFDM LLEATERALALTSKKELMIVGGVAASVSLRKKLEELGKEWNVQIKIVPPEFAGDNGAMIAYAGMLAASKGVFIDV DKSYIRPRWRVDEVDIPWRN Sulfolobus solfataricus NYSGXRC-6240a SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC294 GENBANK AAD06840.1 MNGFCARLRAITFNERLKMKIAVLLSGGVDSSYSAYSLKEQGHELVGIYLKLHASEKKHDLYIKNAQKACEFLGIP LEVLDFQKDFKSAVYDEFINAYEEGQTPNPCALCNPLMKFGLALDHALKLGCEKIATGHYARVKEIDKVSYIQEA LDKTKDQSYFLYALEHEVIAKLVFPLGDLLKKDIKPLALNAMPFLGTLETYKESQEICFVEKSYIDTLKKHVEVE KEGVVKNLQGEVIGTHKGYMQYTIGKRKGFSVKGALEPHFVVGIDAKKNELIVGKKEDLATHSLKAKNKSLTKDF KDGEYFIKARYRSVPTKAFVSLKDGMIEVEFKEPFYGVAKGQALVVYKDDILLGGGVIV Helicobacter pylori NYSGXRC-6240b SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC294 GENBANK NP_281268.1 MKILVAMSGGVDSTVTAYKLKNLGHEVIGCYMKLHGKPNYHEENIKKVEKVANFLQIPYHILDLQEDFKNKVYMPF VDTYKEGKTPNPCALCNRFIKLGKLLEFAKSLGCEKLATGHYARLENNLIKTAVDESKDQSYFLASADKEALKYL IFPLGEMKKEDVKKFASTIEVLKSFATQKESSEICFVEDTYVQVLDQFMDTKIPGEVLDSSGKVVGKHEGYMHYT IGKRRGFEVRGAHEPHFVLKINPKQNQIIVGTKEELKISEFNLKNINLFIDAKELDCEVKIRYRSKSTPCKVEIY EDKSAKIILKDPVYGLASGQMAVFYDHDKVIASGFIE Campylobacter jejuni NYSGXRC-6240c SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble EC294 GENBANK NP_110110.1 MQNKTVFVGISGGVDSAVSALLLKQQYREVIGIFMECWDNTLNNDQLGHRAFNEHKSGCSSKEDFREAQAIAQLLG IKLIKQNLVEPYKQVFLPTIDAFKNGLTPNPDMLCNRLIKFGLMRDYCKQLDPNSDFATGHYAALSWDNNQPLLA IPKDKHKDQTYFLAHVKPAQLQDVVFPLAHLLKTEVRQIALAHHFSVATKKDSTGICFIGERHFSDFLKNYLPVK PGVIYDKTQRQLGSHEGVFYTTGQRSGLNLGGQAARNFVVEKDLKTNTLYVSSDPEDLQRRGITLSHFNWLYQPN PLTQTVLVRIRHAQPLVQGHITVQPNNVVQVQLDQPIDRVTNGQYGVLYTQNGICLGSGIITASQI Mycoplasma pneumoniae NYSGXRC-6240d SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC294 GENBANK NP_357716.1 VKHTRPSIVNKRIDGRLTMSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKD VVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYARVA RDEDGTVHMLRGVDNGKDQTYFLSQLSQEQLQKTMFPLGHLKKPEVRKLAEEAGLSTAKKKDSTGICFIGEKNFK NFLSNYLPAQPGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQGFYHDSL MSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFAEPQRAITPGQAVVFYDGEECLGGG LIDNAYRDGQVCQYI Streptococcus pneumoniae NYSGXRC-6240e SGX Pharmaceuticals 2004-06-10 active Selected EC294 MSGKRVVVGMSGGVDSSVTAWLLKQQGYEVIGLFMKNWEDDDDSEYCSTRQDWIDVVSVADLIGVDVEAVNFAAEY KDRVFADFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMALGADTIATGHYARVREAGGRFELLKAFDHTKDQSYF LHRLNQAQLSRTLFPLGEMPKTRVREIAAEIGLPNARKKDSTGICFIGERPFRDFLNRYLPTKPGPIRTPDGKTI GQHIGLAFYTLGQRKGIGIGGSRDGNGDAWYVARKDMAANTLYVAQGHDHPWLLAHTVHADDLSWVAGHPPAEGT QLAAKTRYRQADAPCAVTRATGDALTLTFQQAQWAVTPGQSAVLYDGDICLGGGIIASTEAASLEQAVA Ralstonia solanacearum NYSGXRC-6240f SGX Pharmaceuticals 2004-08-23 active Selected Cloned Expressed Soluble Purified EC294 ICEDB: T1938 GENBANK NP_248349.1 VIIMKAITVLSGGLDSTVVTLIAKDLGYEVTAITFNYGQRAAKREINSAKKICEILGIEHIVVDLPFVKQFGKSSL ITEKEIPTLKMEELDSEKAYETMKAVWVPARNVIMFGIASGFAEALDAEKIFIGINKEEGVTFPDNTIEFVEAFN KVLEYGTLNKVKIEAPLYDKTKEEIVKLGAELEKKLGVEVLKYSYSCYHDNGEDFLHCGKCESCMRRKRAFLMAG VEDKTKYIE Methanococcus jannaschii NYSGXRC-6240g SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC294 GENBANK NP_070424.1 MITCSKCSRRAVIFQRHANRHLCKRHFIEDFERRVKLAVKKYDMIQKGDRIAIALSGGKDSVTLAFVLNKLYGFRS DLEFFAITIDEGIAGYRPPTVEIARKVTEQLGMEHLVVSFEENFGMTLDEMVKRGDKKPCTYCGVFRKYLLNRTA REMGATKLATGHNLDDETQTILLNFLNADMERMARLVPQRVQEGLVVRIKPFRYVYEKEVVVYGFLHELPMDFDE CPYSHFPVRAAVRDFLYDFENKYPGRKFSVMSSFEKLIPCLKEIYPQIDLNRCERCGEPTPRRICQACKLLEELR GVD Archaeoglobus fulgidus NYSGXRC-6240h SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed EC294 GENBANK NP_348850.1 MNKKVVIGMSGGVDSSVAAYLLKEQGYDVIGVTMKLTPDDAFYTEQEGGCCSLSAVEDARRVAYRIGIPFYVVNFT DIFKEKVIDYFTEEYLNGKTPNPCIACNKYIKFDALLKKAESLGADYIATGHYCRIVEENGRYVIRKSEDEKKDQ TYVMYNMTQDQLKHTLMPCGDYKKDRIREIAREIGLNVFDKKDSEEICFIPDNDHGGFIKRECPKAVKTGNFVDK EGKVLGKHKGIIYYTIGQRKGLGIATGKRVFVTNIDAMKNQVVIGEEEEIFENELISFKNNFIPFDKLTEPMEVD AKIRYNAKASKATIYPVDDENVKVKFEKPQRAITKGQSVVFYDGDLLVGGGIIK Clostridium acetobutylicum NYSGXRC-6240i SGX Pharmaceuticals 2004-07-21 active Selected Cloned Expressed Soluble Purified EC294 GENBANK YP_001928482.1 MDVAALVSGGVDSSVVVHRLCEEGYKPAIFYIRIGMEDKDGYIDCPAEEDIELTTLIARRYGCPFEVVDLHKEYWE RVVSYTVETVRRGLTPNPDMMCNKLIKFGCFEERWGYQFDRIATGHYATTDLLNGKTYLSTAKDPVKDQTDFLAQ INFAQISKLMFPIGHLLKSEVRAIANAAGLPSAKRKDSQGICFLGKIDYNDFIERYLGKKEGRIIELETGKVIGR HQGYWFHTIGQRKGLGLSGGPWFVVKKDIKRNIILVSRGYDPDAQYGKTIEMETFDFITEDAYEAGYWNREDATP VTFKIRHTPEFTRGLLYKGEKGYRLESEERIQGIAPGQYCVIYDEDHHLCYGSGMITKGR Porphyromonas gingivalis NYSGXRC-6240j SGX Pharmaceuticals 2004-06-10 active Selected EC294 MKCKFCSREAYIKIHYPKMYLCEEHFKEYFERKVSRTIERYKLLTKDERILVAVSGGKDSAVTAYVLKKLGYNIEC LHINLGISGYSEKSEEYAKKQCKLIGAPLHIVRIKEILGYGIGEVKTRRPPCSYCGLTKRYIMNKFAYDNGFDAI ATGHNLDDEASFLLNNILHWNTEYLAKGGPILPQQGKFIKKVKPLYEVTEREVVAYALAVGLEYIVEECPYARGA TTLDMKGVLNELEEKRPGTKFNFVRGYLKKKKLFEPEIKEKEIKECKICRMPSSGDICAFCKFWGLKKEINFKVS STDEEPFGP Pyrococcus horikoshii NYSGXRC-6241a SGX Pharmaceuticals 2004-09-14 active Selected Cloned Expressed EC4301 GENBANK NP_215465.1 MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDDLDLGDDCVFDYEAQLLAAPELDDLDDADDLA PEWLVAPTVVLTPEVTPVSRRVGQHRKQPIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALN EGSGSNPPRGVQVIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGID LANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGERVMAGDQIATMGSRGFSTGPH LHFEVLLGGTERVDPVPWLAKRGLSVGNYTG Mycobacterium tuberculosis NYSGXRC-6241b SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC4301 GENBANK NP_289291.1 MSAGSPKFTVRRIAALSLVSLWLAGCSDTSNPPAPVSSVNGNAPAHTNSGMLITPPPKMGTTSTAQQPQIQPVQQP QIQATQQPQIQPVQPVAQQPVQMENGRIVYNRQYGNIPKGSYSGSTYTVKKGDTLFYIAWITGNDFRDLAQRNNI QAPYALNVGQTLQVGNASGTPITGGNAITQADAAEQGVVIKPAQNSTVAVASQPTITYSESSGEQSANKMLPNNK PTATTVTAPVTVPTASTTEPTVSSTSTSTPISTWRWPTEGKVIETFGASEGGNKGIDIAGSKGQAIIATADGRVV YAGNALRGYGNLIIIKHNDDYLSAYAHNDTMLVREQQEVKAGQKIATMGSTGTSSTRLHFEIRYKGKSVNPLRYL PQR Escherichia coli O157:H7 NYSGXRC-6242a SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC3460 GENBANK NP_286389.1 MTIKNVICDIDGVLMHDNVAVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAGVDVPDSVFYTSAMATA DFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAYFVANGARFIATNPDTHGRG FYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSS LDDIDSMPFRPSWIYPSVAEIDVI Escherichia coli O157:H7 NYSGXRC-6242b SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC3460 GENBANK ZP_01067190.1 MFFLDVQGTLISDHDKSLIHGAKELIDFLNAKNLPYLIITNNTKKLDFLEKLQQKGLVIKENAYIDPFSVLKHLLR PCKVAAFGADEFVKSLENLGFELDFVNPSAVLVASYDDFKFKDFATMIELARREVRFIAMHETSIYKKDGRPYPG VGSIMAMLKNAIDFEYEVVGKPSIAFYKEALNLIRRQNSKIDFEDIKIISDDFRGDLLKAKELGMKTLLVLSGKI SDTKGLDTDLLDGVYPSVFEFLKDLKCQI Campylobacter jejuni NYSGXRC-6242c SGX Pharmaceuticals 2004-01-20 active Selected EC3460 VFADLDGVIWLGQEPIEDNLVVLRTLASEGRLVVLTNNSTRSRRVYAAMLERVGLDIEPGRIVTSAYSAAVLLKKK LGPSTALVVGEEGLVEELAVEGHVVASSSDNIDVDAVVVGLDRNLTYGKLARAASAIHSGSLFVATNLDHALPTP RGLIPGAGSIVALLEKATGVKPAIVAGKPSRGLAEVLESLFKPVRPLVVGDRIDTDVEFARAWGVDSLLVLTGLY RGVSIEEASRKAGEGVRVARSLSEFCRGG Aeropyrum pernix NYSGXRC-6242d SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed EC3460 GENBANK NP_465924.1 LKNYKAYLIDLDGTMYRGAEVIPEAIIFIENLKRAGLPYLFVTNNSTKTPGQVAEHLTDMGIQAVSDDVFTTSQAT VQFMMEQKREKTVYVIGERGIKQELTDNGFEITSSNPAFVVVGLDREVDYEKFSKAALAVRGGAMFISTNGDAAI PTERGLLPGNGSITSVVSVATETAPIFIGKPESIIMEQALAKLGVHKDEAIMVGDNYETDIMAGINYGMDTLIVH TGFTSKEALLTKEIQPTYAVTKLTDWEFN Listeria monocytogenes NYSGXRC-6242f SGX Pharmaceuticals 2004-10-15 active Selected Cloned Expressed Soluble Purified EC3460 ICEDB: T1940 GENBANK NP_371453.1 MKQYKAYLIDLDGTMYMGTDEIDGAKQFIDYLNVKGIPHLYVTNNSTKTPEQVTEKLREMHIDAKPEEVVTSALAT ADYISEQSPGASVYMLGGSGLNTALTEAGLVIKNDEHVDYVVIGLDEQVTYEKLAIATLGVRNGATFISTNPDVS IPKERGLLPGNGAITSVVSVSTGVSPQFIGKPEPIIMVKALEILGLDKSEVAMVGDLYDTDIMSGINVGMDTIHV QTGVSTLEDVQNKNVPPTYSFKDLNEAIAELEK Staphylococcus aureus NYSGXRC-6243a SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC3696 IRDSKPNKYCCYKVSMYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSG WDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCG AGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAK YNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK Staphylococcus aureus NYSGXRC-6243b SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC3696 GENBANK ZP_01067886.1 MKIKVGLIFSGIACLFLTACVNQVKQNTTFENTLTQKYCGDDFFNQNLEKIKKNDDVIYTGLNAGLIARNCGDFNK SNVFFDAVEESYKYDVDLENVSPKAAKFIGTTLLNDNIVDYDGSLYERIMVNIYKALNYMEEDDYENARVEFNRV LMRQDKAKEYFAKEIEKNRADLDKAKEDKNYDKNMNENSKVIEAQYDNLFKEFDTTKNFINPYATYLASIFFFMD KDYRKAADLFREVAIIYPKNKTIKKEAKIFKEYATKIKVKKAKKYVFVVYENGFGVVKDEFALTLPFIVDKKIIS TNIALQTLKKREASFANLNINGQNTNDFVDLDNIVATEFKINMPAMIAKALAQTIIKTTLNVAVANNDSTGGWLS LATAVATAATNKADVRSWRGLPKSIAIATIENDGNLEIKDPQGNILFQKSLDKNKNALVIVRSFAPYLPASVAIM EK Campylobacter jejuni NYSGXRC-6244a SGX Pharmaceuticals 2004-01-20 active Selected EC827 MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYRKSGEPYIIHPIQVAGILVDLEMDPSTIAGGFL HDVVEDTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRT LKHLPQEKQRRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVDEVVNEVK KRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYIA MPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHEIAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNEST DAEEFMESLKIDLFSDMVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVEI LTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFELKDVLTPENIQKVADKFNF SNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKIVQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSK CCNPVPGDDIVGFITKGRGVSVHREDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVL QAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN Bacillus subtilis NYSGXRC-6244b SGX Pharmaceuticals 2004-01-20 active Selected EC827 MFYNLKLYKFSKMATLVEIERDFLQKTAQKFAPEVVALITKALDYSKKHGEQKRLSGEPFFIHPLRTALRLVENMD SNTVCAGLLHDIIEDTQVTEADLTAIFGKEITDLVVKVTKITSESKKQRQLNRKKEDLNLKSLVNIAMSSQQEVN ALVLKLADRLDNISSIEFLAVEKQKIIAKETLELYAKIAGRIGMYPVKTQLADLSFKVLDPKNFNNTLSKINQQK VFYDNEWGNFKKQLEEMLEQNQIEYRLESRIKGIYSTYQKLTFHEQNIAKIHDLFAIRLIVKSELDCYHLLGLIH LNFTVLMKHFKDYIASPKQNFYQSIHTTVRLKGLNVEIQIRTQRMDHVSKYGFASHWIYKEKKEGLLASALQVNY LNSKQMHSRDFFKRIFGTDIIKVNVSSDNEPNIVKKLNVESNSKLLDIAYELYPKQFNKLEKIKLDGVEVMSFDV TAENEMVIEFCFGKTNNLKRRWLRYMNNHVFRERVKKDLNKLKKAVKYSELPLYEKALEELHLKLADETQIKQRL NALGIKKLTEFLELIEYPHFPKNEHLYFLASNNQKRELIKPIKFALSQAVFQNSYFEQIEGIYITKIVIETCCTK IPDMPEQVIGILMKNILRVHLHDCRELANQKQPKIIPLYNAHQLKMRPRKFRCQINIRGVWSETTVNKIVQTIIE GDSYLERIIPKIDKQKDEFELNITMFIDNYHQLITIMEQITTKNISYVKYL Mycoplasma pneumoniae NYSGXRC-6244c SGX Pharmaceuticals 2004-01-20 active Selected EC827 VCGNAHPRLMTAHDRIRLMLLSRVIIFSTEGEFGGEIVINRTEIETEAKVVIRELESLKKKSFTREEKKLLIKAYE FARIVHEGQKRFSGEPFITHPVEVTKILAGLGVDVTTLVAALLHDVVEDGENVSLDQIKKEFGPEVARIVDGVTK VSNINAPIGRDQDSRKKIETIQKMFFAMAEDMRVIFVKLADRLHNMRTIHYVQDPEKKRYKAYETLEIYAPLAHK LGIYSIKSELEDLAFKVLYPEEYYKIKELVAEKRKEREKRTNEYISLLKSALEEHKIKAIVEGRYKHYYSIWRKM KEKGKKFEEIYDLIALRVIVKDVTTCYTVLGIVHNIWKPLPGRFKDYIAAPKSNGYRSLHTTVITGYGEPLEIQI RDEEMHREAEYGLIAHWIYKERPDVKTAKEWIERLLDWRKELAQGFTEFEDIKKELQMDEVFVFTPKGDILHLPK GSTPIDFAYAIHTEIGHHYSGAKVNGKIVPIDYQLKNGDVVEIIVNKNSPGPSVDWLKYAKTHSARAKIRRFLKE KLAPELVERGKEVLRKICRKLGKSFEEVMQTEGIKRYLNTYQEKDFFMRIGEGSITTQDLIEAILGKKIVVKKRS TKKKTRIQNLVKVDGIDSIEFHIAKCCHPIMGDPIVAVVSRRGMTIHRRDCRNLKNMSQDRIFPAEWNLETSEMF DAHIRVVLNSEKNLPSLIDRITNLGAEFVAMKTLKSEEPLVVQIHIKISNTVELTGLLDRLRSYRYVLDAERVVQ Thermotoga maritima NYSGXRC-6244d SGX Pharmaceuticals 2004-01-20 active Selected EC827 LLLLIGWHSLPNMTHVSLIQTDHAALPLADAKVPDYFLQLERMAAHLTHEQLMALRRAWVMGMAAHAGQTRKSGEP YITHPVAVACVLADLGMDVETLIAAILHDTIEDTSVTREILAAEFGETVADLVDGVTKLDKLKFRNRQEAAAESF RKMLLAMSRDLRVIMIKLADRLHNMRTLGAQSIEARSRIARETLEIYAPIAQRLGMALMKSELQNLGFCALHPWR HAIIEKHILNQPVVRREAMERVELQLSQRLIQEGVQHRVVSRIKTPWSIYNKMHDDNKSFDQVMDVFGFRLVVKS VADCYHALGIVHGTLKPLDGRFRDFIAIPKTNGYQSLHTVLFGPYGSPIEVQIRTEEMDMIAERGIAAHWAYKCG SDSPNSAQSRVHAWIAELLESQRTAISSMEFLDNFKVDLFPDEVYLFTPKGKIFALPKNSTALDFAYAVHTDIGN HAVTSRVDKQLMPLRTKLSSGQTVEIITARSALPKPQWLEFVVSSKARTAIRHQLKQLQHEDAVQLGHRMLDRAL EAMDSSLERLPKGRLDAFLAEHHFQRLEALLADIALGNWMPNQTAQALLTYTELLGNTPIEHSHEKILINGSERG VISFANCCQPIPGDDVMGYHTTGKGIVVHRLDCPNLNELRKSPERWVPIDWDLNVSGDYDASLLVEAENRTGVLA QLAAAIAQSHSNIEHVDYLERDFNAALLRFSIQVRDRRHLAEVMRRLRRLPAVQSVYRQ Xylella fastidiosa NYSGXRC-6245a SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC1528 ICEDB: T1941 GENBANK NP_417173.1 LIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDI EHMLTFMRDLHRYTARNMGDERMLPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHY NFSLPMAFWQAKCGDISGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAICSSFLQGKPTSLPFEKTECGMY YLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYA PIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVN WNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARI LRSMIDTGIGGTGKAFAEAYRNLLREEPLEILREEDFVAEREGFERRQQEMEAADTEPFAVWLEKHA Escherichia coli NYSGXRC-6245b SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC1528 MIKLDMTMLDSFKEDPNLRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVT DSIDSVYEWLENLHNIVSLRSENELLWPSSNPPILPAEEDIPIAEYKTPDSPDRKYREHLAKGYGKKIQLLSGIH YNFSFPEALIDGLYANISLPEESKQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHEESLPDGSSA LRDGISLRNSNAGYKNKEALFVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQTVESLAEHGVEYL EIRSIDLNPLEPNGISKDELDFIHLFLIKGLLSEDRELCANNQQLADENENNIALNGLAQPSIKNCDNEDIPLAD AGLLELDKMSDFIKSLRPEDTKLRAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYK LIGAEDMELSTQIIWKDAIARGIKVDVLDRAENFLRFQKGDHIEYVKQASKTSKDNYVSVLMMENKVVTKLVLAE HDIRVPFGDSFSDQALALEAFSLFEDKQIVVKPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIP GDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELVEEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDS IPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRATQVLDAKICGVDIIVPRETIDRDKHAIIELNFNPA MHMHCFPYQGEQKKIGDKILDFLFD Listeria monocytogenes NYSGXRC-6245c SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed EC1528 GENBANK NP_348166.1 MHWSFPEMIRLFSDEYRSSMLSEGNFGVERESQRVNYSGDLALTPHPSVFGDKFENPRITTDFSESQIEMITPPLK SAEEVYKALNDINNEVKNALKGELLWPLSMPPRLPKEEDIPVAQFPDTEDGRQKQIYRNGLALRYGKKMQMISGI HYNFSFSDKMIDFIYRQLRIEKTKRQFIDEMYFSLTRNFLRYHWILIYLFGASPICDSTYNSVIFKELEKIEKCC PHCAGKIKNFNRYATSLRVSRFGYSDTDEKKYTVYFNSLREYETKIKKMMETESNKYSKLGIYKDGVQIQLNGNL LQSESEFYAPIRFKRNIKKGETQLTALVNRGVEYIEIRILDVNPFDKVGISVEQMNFLQVFNVFCLFEESKSIDE EQMERINTNHQLAALLGRNEDLMLYKYNDDSRIPLKNFGDEIFEKLRIVAKLMDKDNVEKKYSESVESEYKKLHN IELLPSERICREMDNDNRSYIQFGMEYAEA Clostridium acetobutylicum NYSGXRC-6246a SGX Pharmaceuticals 2004-09-27 active Selected Cloned Expressed Soluble EC1426 GENBANK NP_247989.1 MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIGLYNILTENERENVKNK KIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEEEKFLIPTTPSTRDVLKNNLNADLLFVYKSAE PENLKEDIKKLKELIAKDKFILTFTSGLTAKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYT IEGMLEVIRTLKER Methanococcus jannaschii NYSGXRC-6246b SGX Pharmaceuticals 2004-01-20 active Selected EC1426 MKRSGKVYIIGAGPGEEELITLKAIRKMKECTAVLYDRLVGQGILKYLNEKCEIYYCGKEPGCHYKTQDEINEMII KLAKEGHIVGRIKGGDPYIFGRGGEEGLSLLKENIEFEVISGVTSPVAVLNYAGIPVTHRGIARSFHVFTAKTAN DDSINFSAAAKIDGTLIFLMGYRQLNDITRKLIENGMDSKMPCAVVMRGTTSLQKKVIGNLSDIKEKCDNANMTS PCIIVVGKVVGFNQQLNWYEKKPLFGRNICITRSKNQSKTMREELLDLGAEVTEVHSIEIENTASNLEEYINKIS EYDYIILTSVNAVEVLFDYLASKDYDVRKVRAKFAVIGNATKEALKKRGIVPEIVSRKHNGEGLFDEIRGYLKKD DKIFIPRSENSRKYIKEQLVSLGLSVDECFIYRTVPGKLYDKAAFENADTIVFTSPSTVKNMIALFGEKNIKKKS IIAIGPITGRELGKINAEYSTCSECSVDAIIRECLNSDK Clostridium acetobutylicum NYSGXRC-6246c SGX Pharmaceuticals 2004-08-20 active Selected Cloned EC1426 GENBANK NP_465080.1 MSKKVVLTREASKNKPWQTYFSQNGYEVMSIPLIKTQPIKINLTREQQETDWLFLTSANAVEYFFTNQYERSNYKI AVIGEKTKEKLAEFGHEPSFVPSIYQSEVFLEEWLNENPEKTSILLPQSNLSRTIIKDTLIEKGYIVFSIELYET IFPEASKKLLTEQLKLNETQIIVFASPSAWKNFYSIAKSFPAQKEKWHIASIGSITTEAILADGWEVKYQPKTFT MKHLADLIIQEELK Listeria monocytogenes NYSGXRC-6246d SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble EC1426 GENBANK NP_372193.1 MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYLKGINVDNIAVIGSKTA QYCESLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPLLLAALSKDNEVVKIDLYTSVPNKQNIQDVKE MIEHQQIDALTFSSSSAVRYYFNEGFVPKFKSYFAIGEQTARTIKTYQQPVTIAEIQTLESLIEKILESRG Staphylococcus aureus NYSGXRC-6246e SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble EC1426 GENBANK NP_214213.1 VWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFDYIVFQSKKAVKIFLGK VNLKGNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFKRLPKGKVLIPRSKIGRTELIKFLKETSFEVF ALDVYTTEYVFYTREELLEKLNKGDFIIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNV ITSERPSTEDIVKKLKELARDLQK Aquifex aeolicus NYSGXRC-6246f SGX Pharmaceuticals 2004-01-20 active Selected EC1426 MTQQNGKVYLVGAGPGDVAYLTVKAYNLLATAQVLVYDALVDEQLLQCVSSDCLKLDVGKRGGKPSTPQTEINNLL VKFCQEGALVVRLKSGDPFIFGRSTSEIEALKAAGCEFEVVPGISSAIAAPLLAGIPLTDPVMSRCFAVLTAHEP EVLDWEALSRLDTLVILMGGKNLADIVHELLRRERSHLTPIAIIRWAGTPSQEIWTGQLGDILQQTAGLSLSPVV IVIGEVVRLRKYLQPEKIFPENSTTPMSSNQPLTGKTILVTRSSGQSSQFSDRLTTLGATVIEMPALEIGPPSSW KELDQAIANLSHFDWLILTSTNGVDYFFERLYIQGKDTRALAGLKIAVVGEKTSQSLKQRGIQADFIPPNFVADS LVEHFPESLLNKKILFPRVESGGREILVKELSAKGADVIEVAAYQSCCPTSIPLAAELALKNRTIHIITFASSKT VQFFCQLADKIFPHNIPNALEGICIASIGPQTSKTCHTLLGRVDIEAEEYTLDGLTQAIIQWSLKP Nostoc sp. NYSGXRC-6246g SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble Purified EC1426 ICEDB: T1942 GENBANK NP_341740.1 MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSVICFKDRTLIKNVHKIY AIGEETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSIRSRKASEDMRNILNGKIKYDEIYVYDSEIIR DNINEISKILTECEVDAIAFTSSLMAKLIGPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIET ILVEMKRNGRD Sulfolobus solfataricus NYSGXRC-6247a SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC372 PFAM PF00696 GENBANK NP_289370.1 VVKERKTELVEGFRHSVPYINTHRGKTFVIMLGGEAIEHENFSSIVNDIGLLHSLGIRLVVVYGARPQIDANLAAH HHEPLYHKNIRVTDAKTLELVKQAAGTLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSG RIRRIDEDAIHRQLDSGAIVLMGPVAVSVTGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVTNDDGDIVSELF PNEAQARVEAQEEKGDYNSGTVRFLRGAVKACRSGVRRCHLISYQEDGALLQELFSRDGIGTQIVMESAEQIRRA TINDIGGILELIRPLEQQGILVRRSREQLEMEIDKFTIIQRDNTTIACAALYPFPEEKIGEMACVAVHPDYRSSS RGEVLLERIAAQAKQSGLSKLFVLTTRSIHWFQERGFTPVDIDLLPESKKQLYNYQRKSKVLMADLG Escherichia coli O157:H7 NYSGXRC-6247b SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC372 GENBANK NP_148011.1 VDVELEVSGFIQRLRHSRLRGLLVVGTGDVKAWAEKLAGYAGGDCALVSPSAGRLPGICRSWAPPGSIERILGGEY AAAIIAVPGLLRPSIIAGAGETVRSGGFLAIVADPPDRWDPGPPRGTGLYREYLFSAIRDNPVHLWIDDESGRIV SESFLEYTGVGAQGWSPGRYKPSPGSGVPRRLVSACRSESQARALESLARFFRGRWRSALVRGDRGRGKSYVIGL ALAYAAWRRLIGRAVLVGPTPLSVQSVMAGLLRGLDVLGLKGHRVVRTSGGEVIRVSGPWFRIAYEQPDTAEPSP LVVVDEAAAVGVARVRRLSWRSGKSLVATTIHGYEGSGRAFARLLPNILPKPFIELELREPIRYLPGDPLEEWLY TVFMLRAEPQEPGDPSAARPVEVSREVLARDREVLRSVYGILVQAHYRNTPDDLLAMLESPHHRIYALEADGTPV AVADVVLEGPDVEEEARIALERLLYMAGSPGSGVVSWRVSRIAVHEDLQRRGLGSRLLRHVEAQARESGASLVTT MFSRHDVIPFWLKNGFKPFYVSPRYNRVTGEKNVALAKPLDSAGAEILEKASKTLALKLALAGSSIYRDLAAEKL ALLLHHTPATAPPLYLTRIQARHLEGFLKGEVMADQAFDAVYIALLSTLLATRSWNPVEPGLVGAVARVVQGKPY SEVASIIGASTVDEAVGKVEEYIRGILEGARSLWSGRVIP Aeropyrum pernix NYSGXRC-6247c SGX Pharmaceuticals 2004-06-10 active Selected EC372 PFAM PF00696 MPDYVNWLRHASPYINSHRDRTFVVMLPGEGVEHPNFGNIVHDLVLLHSLGARLVLVHGSRPQIEARLAARGLAPR YHRDLRVTDAPTLECVIDAVGSLRIAIEARLSMDMAASPMQGARLRVAGGNLVTARPIGVVEGVDYHHTGEVRRI DRKGIGRLLDERSIVLLSPLGYSPTGEIFNLACEDVAMRAAIDLEAEKLILYGAEQGLLDASGKLVRELRPQQVP AHLQRLGNSYQAELLDAAAQACRAGVKRSHIVSYTEDGALLSELFTRTGNGTLVAQEQFEQLREAGIEDVGGLIE LIRPLEEQGILVRRSREVLEREIEQFSIVEREGLIIACAALYPIADSEAGELACLAVNPEYRHGGRGDELLERIE ERARGLGLKTLFVLTTRTAHWFRERGFQPSSVERLPAARASLYNFQRNSQVFEKSL Pseudomonas aeruginosa NYSGXRC-6247d SGX Pharmaceuticals 2004-09-14 active Selected Cloned EC372 GENBANK NP_274872.1 PFAM PF00696 MSAPDLFVAHFREAVPYIRQMRGKTLVAGIDDRLLEGDTLNKLAADIGLLSQLGIRLVLIHGARHFLDRHAAAQGR TPHYCRGLRVTDETSLEQAQQFAGTVRSRFEAALCGSVSGFARAPSVPLVSGNFLTARPIGVIDGTDMEYAGVIR KTDTAALRFQLDAGNIVWLPPLGHSYSGKTFYLDMLQTAASAAVSLQAEKLVYLTLSDGISRPDGTLAETLSAQE AQSLAEHAGGETRRLISSAVAALEGGVHRVQILNGAADGSLLQELFTRNGIGTSIAKEAFVSIRQAHSGDIPHIA ALIRPLEEQGILLHRSREYLENHISEFSILEHDGNLYGCAALKTFAEADCGEIACLAVSPQAQDGGYGERLLAHI IDKARGIGISRLFALSTNTGEWFAERGFQTASEDELPETRRKDYRSNGRNSHILVRRLHR Neisseria meningitidis NYSGXRC-6247e SGX Pharmaceuticals 2004-06-10 active Selected EC372 PFAM PF00696 VAHTPATADVAPIPPTPEQQQFVDWLRAVAPYIHAFRDKTFVIGFGGELVKAGMLGALVNDIALLHAMGMHIVLVH GSRPQVEEQLALRHVQTQFVDGIRVTDNAALESAKEASGELRLDIEATFSQALPNTPMAGARISVVSGNFVTARP VGIVNGVDFQHTGLVRKIDAESIQHSLSNRKIVLLSPLGFSPTGQAFNLSMEDVATNTATALKADKLIFITEVPG IMDRVGKLQQELSMESAIERLREGRLSADTAYYLQHIVKAMRGGVRRAHLIPFALDGSILLELFLHDGVGTMVSH TDLEYLREATLDDVGGIVQLIEPLEADGTLVPRERRLLERDIANFSVIEHDGIIFGCAALYPYPKEGVGEMACLT VAPDTQGTGDGERLLKHVEARARAVGLKRLFVLTTRTEHWFLKRGFVHATVDDLPEDRRKLYNWQRRSMVLMKKL Ralstonia solanacearum NYSGXRC-6247f SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble Purified EC372 ICEDB: T1943 GENBANK NP_344134.1 MNDQIKIRKATKEDWEKIYQLYNSLSDEDLYLRFFHLYRITEEDAKKIASNEDHVTFLAEVDGKVVGEASLHKDGE FSLVVHRNYRTLGIGTLLVKTLIEEAKKSGLSTVKFYTLPENTPMIKIGRKLGFKMRFYEDEVYGEMRLTERELN VNLATFSAP Sulfolobus solfataricus NYSGXRC-6247g SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed EC372 GENBANK NP_231947.1 LRIFKHQGCSAVKIRSTALVKGFRQSAPYVNAHRGKTMVVMLGGEAIADKNFPNIISDIALLHSLGVKVVLVHGAR PQINQILEKNQRDTPYHKGVRITDESSLGLVMQAAGQLQHAITARLSMSLNNTPMAGTQLNVVSGNFIISQPLGI DEGVDYCHSGRIRRIDVEGINRMLDLGSIVLLGPIASSVTGECFNLLSEEVATQVAIKLKADKLIGFCPQQGIID TKGNAIAELFPSDVERLVKSMEQECAPDDEECFSTMRFLRAALKACRAGVPRSHLVSYKEDGALIQELFSFDGIG TQIVMASAEQIRQATIDDIGGIFDLIRPLEEQGILVRRSREQLEQEIHKFTIIDKDGLVIGCSALYPYPEERMAE MACVAIHPEYRDGHRGLHLLVHSKHQAKQMGIRHLFVLTTHSTHWFREQGFNEVDVEALPMAKKSLYNYQRRSKI LMLQL Vibrio cholerae NYSGXRC-6248a SGX Pharmaceuticals 2004-06-10 active Selected EC4321 MNKKKMILTSLASVAILGAGFVASQPTFVRAEDAPVANQSQAEKDYDAAMKKSEADKKEYEDVKKVLGEAEAAQKK YEDDQKKTEEKAEKANAASEEIAKANRGSFKKAVLDNITVIRNSQRKWEKSRREAEKKAKERETAARKKFDTIQT TIVVLEPDELAKTQKKAEEAAKNKPELTKKLEEAKVKLEEAEKKATEAKQKLDAEEVALQAKIAELEYEVQRLEK ELEEINESDSEDYAKEGFRAPLQSKLDAKKAKLLKLEELSGKIEELDAEIAELEVQLKDAEGNNNVEAYFKEGLE KTTAEKKAELEKAEADLKKAVDEPETPAPAPAPAPAPAPAPAPAPAPAPAPKPAPAPKPAPAPAPAPAPKPAPAP KPAPAPAPAPKPEKPAEKPAPAPKPETPKTYG Streptococcus pneumoniae NYSGXRC-6248b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC4321 GENBANK NP_213722.1 MKKYIGVFTVVALIVGFGIYAFFFIKHRIEYAITNAVFVKADELSYLSFRVSGKVIEVYKDLGDYVKRGEALAKLD PTYYELEKRTLEKKMSALLEKKKALEIKIQKLEKGLHISLSAKKLKVESLKKKREALREKLLQVEEKIKLVKLDW ERYKSLFQKGLIPRRKFEEVDTNLKVLLHEREYLEKSIQEINTEIKRAKKGIENARNEFKTIEELKKELSSLEEE IKSLKERIKTAEQKIKDTVLIAPFDGVVAKRFISRGDVVRAGQPAFALVNPESFYVEVLLEETKLKGVKVGNKAY VRLDAYPDILFEGVVEEISPASAATFALVPRDVSAGEFTKVVQRIPVKIKITKGDLSLLRVGMGGEVEIRRTR Aquifex aeolicus NYSGXRC-6248c SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC4321 GENBANK NP_395816.1 MWNVDVTCIGGIRSGEATLRPGPNIVQASNFQGKSSFLAAIQTAIGTTGLLTEDHPLMENEDDGKVTLETDEETYT VSLTRATDSDEPAISRSGTPYLTRDQDQIAARLFAVLGEDNPIRAAVREENQERLTELLKKPLETENIDLRIEAL QREIKELEDEVAAAEAASADLPAAQQKVTRLQGELRDLNETRDELERKVDEETDQRALRDELTAKQSDLEREEAR LERLENQVDRRKAQLDDKEAALESLDIPDSPTAEADIAEKQTRIDELAVKIDLLDDLHRSTKAIIDEGEIDLITD VERTLSGDTFSCFVCGAETTAEAVTERLNEISDRQESLREQRATLTEEVTQMQQRTREIESKRQQKAELEDEIKR LRVDIQEDQHEVRSIEATIEELQAEIEQREAEYEAAEKAGESHSAELKTIQQKIGSTETKLDRAQAELERIEAEL QKRNDRQEQLETKRDELETLRQRRKQKYNELVNQFDAAMADIIGRFAPGFDGAYLDQKTDANDTVGFEINLARDG HTTDLDTLSEGERELVGIVTALAGYRTFSVGDRVPCILLDGIGQLAAEHIRHMIEYLENTAEILVTTAYPEAGSF DGETVSPEHWDVISHETAQSRDHPQITN Halobacterium sp. NRC-1 NYSGXRC-6248d SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC4321 VDYLESLDFPKVVEIVKKYALSDLGRKHLDTLKPTVNPWDELELVEELLNYFNRWGEPPIKGLNDISQEVEKVKSG SPLEPWELLRVSVFLEGCDILKKEFEKREYSRLKETFSRLSSFREFVEEVNRCIEQDGEISDRASPRLREIRTEK KRLSSEIKRKADDFVRTHSQILQEQMYVYRDGRYLFPVKASMKNAVRGIVHHLSSSGATVFLEPDEFVELNNRVR LLEEEERLEISRILRQLTNILLSRLNDLERNVELIARFDSLYARVKFAREFNGTVVKPSSRIRLVNARHPLIPKE RVVPINLELPPNKRGFIITGPNMGGKTVTVKTVGLFTALMMSGFPLPCDEGTELKVFPKIMADIGEEQSIEQSLS TFSSHMKKIVEIVKNADSDSLVILDELGSGTDPVEGAALAIAIIEDLLEKGATIFVTTHLTPVKVFAMNHPLLLN ASMEFDPETLSPTYRVLVGVPGGSHAFQIAEKLGLDKRIIENARSRLSREEMELEGLIRSLHEKISLLEEEKRKL QKEREEYMKLREKYEEDYKKLRRMKIEEFDKELRELNDYIRKVKKELDQAIHVAKTGSVDEMREAVKTIEKEKKD LEQKRIEEATEEEIKPGDHVKMEGGTSVGKVVEVKSGTALVDFGFLRLKVPVSKLRKTKKEEKKETSTFSYKPSS FRTEIDIRGMTVEEAEPVVKKFIDDLMMNGISKGYIIHGKGTGKLASGVWEILRKDKRVVSFRFGTPSEGGTGVT VVEVKV Thermotoga maritima NYSGXRC-6248e SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC4321 MILLQLNHISKSFDGEDIFTDVDFEVKTGERIGIVGRNGAGKSTLMKIIAGVENYDSGNVSKIKNLKLGYLTQQMT LNSNATVFEEMSKPFEHIKRMESLIKEETDWLSKHANDYDSDTYKTHMSRYESLSNQFEQLEGYQYESKIKTVLH GLNFSEEDFNKPINDFSGGQKTRLSLAQMLLNEPDLLLLDEPTNHLDLETTKWLEDYLRYFKGAIVIISHDRYFL DKIVTQIYDVALGDVKRYVGNYEEFIQQRDLYYQKRMQEYESQQAEIKRLETFVEKNITRASTSGMAKSRRKILE KMERIDKPMLDAKSANIQFGFDRNTGNDVMHVKNLEIGYQTAITKPISIEVSKGDHIAIIGPNGIGKSTLIKTIA NQQKALNGDITFGANLQIGYYDQKQAEFKSSKTILDYVWDQYPLMNEKDIRAVLGRFLFVQDDVKKIINDLSGGE KARLQLALLMLQRDNVLILDEPTNHLDIDSKEMLEQALQHFEGTILFVSHDRYFINQLANKVFDLTIDGGKMYLG DYQYYIEKVEEAEALKAHQEEQSVNVQAHKKSMEQSSYHNQKEQRREQRKLERQISECENEIETLETTILQIDEQ LTQPEVYNNPQKANELAIQKQDSEQKLEHAMSKWEELQQKL Staphylococcus aureus NYSGXRC-6249a SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble EC4901 GENBANK NP_417839.1 MARFVVLVIDSFGVGAMKDVTLVRPQDAGANTCGHILSQLPHLQLPTLETLGLINALGYAPGDMQPSDSATWGVAE LQHEGGDTFMGHQEILGTRPLPPLRMPFRDVIDRVEQALVSAGWQVERRGDDLQFLWVNQAVAIGDNLEADLGQV YNITANLSVISFDDAIKIGRIVREQVQVGRVITFGGLLTDSQRILDAAESKEGRFIGINAPRSGAYDNGFQVVHM GYGVDEKVQVPQKLYEAGVPTVLVGKVADIVNNPYGVSWQNLVDSQRIMDITLNEFNTHPTAFICTNIQETDLAG HAEDVARYAERLQVVDRNLARLVEAMQPDDCLVVMADHGNDPTIGHSHHTREVVPVLVYQQGMIATQLGVRTTLS DVGATVCEFFRAPPPQNGRSFLSSLRFAGDTL Escherichia coli NYSGXRC-6249b SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed Soluble EC4901 GENBANK NP_295858.1 VPGAHYTLPMQLTIIVLDSVGAGALPDAAAFGDAGAHTLNHTLKQAPVPLPHLARLGLGKLPTIDTSPETVPADAE VTGAYGRMREVSPGKDTSTGHWEFMGVQLEHPFQVFPDGFPPEVMDRFDAATGRGHLCNKPYSGTDVIRDYGEEH RRTGFPIVYTSADSVFQIAAHEDVVPLETLYEWCRAAREILQGEYAVARVIARPFRGEPPFERANEHRRDFSLTP PRTVLDALKEAGKDVVGIGKIPDIYAGQGFTESIHTDDNADGIRKTLERMKAGVDGLIFTNLVDTDAKFGHRRDP AGYSNALAEFDRALPDLIAALPEDGLLIILSDHGNDPTWHGTDHTREYGLLLAYGHGLSARDLGERETFADVGAT VAEALGAQWDGPGTSFWNELR Deinococcus radiodurans NYSGXRC-6249c SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC4901 GENBANK NP_280193.1 MVVTSAAGTVLVTVDSLRADARSRVETPTLDALADSGTVFERAYAHGNWTPFSFPSVLGDSHVFAADGAIGVGDTT LAGRLADAGVRTAGVNAANGFLTEHWGYDRGFDTYDAFTDTNSRLGRTLAAHPTVQGWLQVGASPFRRRSDGRER VDATRMLDIEDRAVEFLSAASEPFFLWLHYMDTHTPYVPAPRHLRATTDRRGAMLGMLSAHLRVGLGLTVSSATA GELHTLYDATVRQVDTSIGRVLAALGDRREDTMVVVAGDHGEEFLEHGHLAHYPKLYDELVHVPLLVDHPAGAGG RVSTAVGLSDVPATVLDVMGGSTRGFTGESLAPEIRAGTEPTRGPITSVAVRGASVTQQPIPRHLGAGRPLVSAR DGRWTYIRDPERDTHELYDRASDPGEQTDVSGTADPPLDALHAATRQRLDAIRTDGDAAAATPDDVERRLSALGY R Halobacterium sp. NRC-1 NYSGXRC-6250a SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC2219 GENBANK NP_388123.1 MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGADCAITASYQSTFEGFA ARGLSEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHR PRMKALIEAGADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALG INCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESYGASARTWHEKGARLIGGCCRTKPEN IQEIAAWARSLKTT Bacillus subtilis NYSGXRC-6250b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2219 GENBANK NP_518416.1 MTAPLPYTRAANLPALLRERILILDGAMGTMIQRYKLTEAQYRGERFASHPVDVKGNNELLLLTRPEVIREIHEQY LAAGADLIETNTFGATTVAQEDYKMAELAYEMNVVAARLAREACDKYSTPDKPRFVAGAFGPTPKTASISPDVND PGARNISFDQLRDAYYEQGKALLEGGADVFLVETIFDTLNAKAALFAIDQLFEDSGERVPVMISGTVTDASGRIL SGQTVEAFWNSLRHAKPITFGLNCALGAALMRPYIAELAKICDTAVSCYPNAGLPNPMSDTGFDETPEVTSSLVD EFAAAGLVNLVGGCCGTTPEHIRAIAERVAQRKPRAWPGQYREAA Ralstonia solanacearum NYSGXRC-6251a SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2349 ICEDB: T665 GENBANK NP_372145.1 LSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEK EYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQ TYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDG KKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQG FECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV Staphylococcus aureus NYSGXRC-6251b SGX Pharmaceuticals 2004-09-14 active Selected Cloned EC2349 GENBANK NP_248152.1 MLDSPHNLYIKKFMLCYIIYYFLICHLYNHIFNLREIMLCSCGNEAFYYQKYSNRHLCKECFKKDIERRAKKVLGK DIIRNNVKIGIGISGGKDSLVMAYILKELFKHIPNAKLICFFVDEGIKGFRNIAEKYVKEFCKEYNLDLKIIKFE DEIGYTLDEIVKNDYLSKLNIGKPCSFCGVVRRYLLNKHALKEGCDYLAIGHNLDDFCQTILMNYVEGNIKNIIQ FGKEFEGGGFVKRIKPLKLIPEEEVKLYAEINNIKYQREPCPYSSLSYRHRMKKVIEILEEEKPGVKFSILRGYE KLLKYLNVKEEIRRCEICGFPCSGNICKVCSWLIKLKEIK Methanococcus jannaschii NYSGXRC-6251c SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC2349 MTDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIGIPYYSVNFE KEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVSRDADGTVHMLRGADNNKD QTYFLSQLSQEQLQKVMFPLGHLQKPRVREIAEKAGLVTAKKKDSTGICFIGEKNFKEFLSSYLPAQKGRMMTID GRDMGEHNGLMYYTIGQRGGMGIGGQKGGDNAPWFVVGKDLSQNILYVGQGFYHDALMSTSLTASQVHFTQNMPD KFTLNCTAKFRYRQPDSKVDVKVNGDKAEVIFDEPQRAITPGQAVVFYDGDECLGGGLIDNAYQEEKICQYI Streptococcus mutans NYSGXRC-6251d SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble EC2349 MRVSLFLQKQIIECSKAFQPHSTRLQWPKSQDKVFVAMSGGVDSSFSAYLLKSQGYNVEGVFMRNWLDEDSAPSGC PAERDWATVQKVCKKLNISCRRFNFEKEYWNLVFEPSLDLYENGLTPNPDVSCNRQVKFGALFDALKKHCENNVK GDWWLASGHYAKSVVNIETNESHMCIPTDKRKDQTLFLCTIRKEALEKTIFPLHNWTKENVKKQASSAGFKEIAE KQESQGLCFVSPNVGRKFRKFLQRYLNFSDRPIKVIAGKNVVGEFSGNHGIWSLTVGERCGLSLPQAQSEYFGRW YVWKKDIKNNALYICRGTNNELLMSKCIYLKDWKWCGTKLQNLEKSALSCFVRVRHQQPLQPAKVTWRNPESVKI HFQDKQRAVTPGQVIAVYVNDVCLGGGMVDTVEPEKDFD Schizosaccharomyces pombe NYSGXRC-6251e SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2349 GENBANK NP_270096.1 MTDNSKIRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADKIGIPYYSVNFE KEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVKRDENGTVHMLRGADNGKD QTYFLSQLSQEQLQKTLFPLGHLQKSEVREIAERAGLATAKKKDSTGICFIGEKNFKQFLSQYLPAQKGRMMTID GRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNQPWFVVGKDLSQNILYVGQGFYHEALMSNSLDASVIHFTREMPE EFTFECTAKFRYRQPDSHVAVHVRGDKAEVVFAEPQRAITPGQAVVFYDGKECLGGGMIDMAYKNGQPCQYI Streptococcus pyogenes NYSGXRC-6251f SGX Pharmaceuticals 2004-01-20 active Selected EC2349 VIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDVLCNKEIKFKAFLEHALSLGADYLATGHYARVDR SGGKVRMLRGIDENKDQTYFLNQLTEDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTF LSQYLPAQPGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHNPLLYSDKIT ATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQVRAVTPGQAVVFYDGEECLGGGTIDD VYKDGTKLWYV Bacillus subtilis NYSGXRC-6251g SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble EC2349 GENBANK NP_295482.1 MAQSVAGSSVLTPGLTVSGPHSHARHSATLPSAMTAFPAAPDLAPPSRAAQGERVLCAMSGGVDSSVTASLLKEQG YQVIGAMMRFWPDDKRTDTFDSCCSPDAAYEARRVAEQVGVPFYLLDYREPFQRHIVGPFLEEYARGRTPNPCVN CNTKVKFDELVKKAKMLGCRYVATGHYVKRVDNAQGEVEFHRGDDPRKDQTYFLWGTPRDALPYILFPVGELEKP QVREIAAERGLLTAQKPESQNICFVPGKVQDFVAEHLPQAQGYIREIATGEVVGEHLGTQFYTLGQKKGLGLYQS HRVRHVVHLDPDSNTVWVGDYDDCLWTGLKATDANYLLDLAELPTELEVQVRYRTAPVKAHVLHADAEGFELEFA EPQFAVAPGQSAVLYAGSRLLGGGLIADHARELPALT Deinococcus radiodurans NYSGXRC-6251h SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble EC2349 GENBANK NP_578002.1 MYLCEEHFKEYFERKVARTIEKYKLASKDERILVAVSGGKDSAVTAYVLKKLGYKIECLHLNLGIGEYSEKSEIYA KKQCEFIGAPLNIIRVKELLGYGIGEVRTSRPTCSYCGLTKRYIMNKFAYDNGFDAVATGHNLDDEASFLMNNLL HWNTEYLAKGGPLLPGEGKFVKKIKPLYELTEREVVAYAIAVGLEYIVEECPYARGATTLDMKEVLNELEEKRPG TKFNFVRGFLRKKKLFEPEVKGKDLKECKICGMPASGEICSFCKFWKLGKPLTFKIK Pyrococcus furiosus NYSGXRC-6251i SGX Pharmaceuticals 2004-06-10 active Selected EC2349 MNTPRIIVAMSGGVDSSVAAWRLNSQRETIAGLFMRNWTDDGNGQCHAEEDRRDAVAVCGILGIAFHFRDFSHEYW QEVFTHFLAEYANGRTPNPDVLCNREIKFKHFLETARELGADSIATGHYARIKHYRQRWHLLRGADRSKDQSYFL HQLGQEQLAATMFPIGDLEKPQLRQLAHQAGLPTHAKKDSTGICFIGERNFREFLKQYLPAQPGEIRDPQEQRIA EHPGVFYFTLGQRQGLNIGGVRNRPPSPWYVIGKDLATNVLYVDQHRDSPFLQSRWLRSEPAHWVSGSPPAPTFT CTAQTRYRQADEPCKVTVRNDGSLDVDFTQTQWAVTPGQSLVLYDGNECLGGAVIATTDAPLERKRARNLSKTEN VLQ Xylella fastidiosa NYSGXRC-6252a SGX Pharmaceuticals 2004-06-10 active Selected EC2480 MAVGLGPLSTLHPVPGFELGIASAGIKRPGRKDVVVMRCAEGSSVAGVFTLNAFCAAPVTLAKQRFLGEVRYLLTN TGNANAGTGEAGLAAAAQTCAKLAELAGVAETSVLPYSTGVIGEPLPVAKIEAALPAALADLAEDRWAEAAAGIM TTDTLPKGASRQFVHDGVTVTVTGISKGAGMIKPNMATMLGYIATDAKVAQGVLQDLLRDAANKSFNRITIDGDT STNDCCMLIATGRAALPEVTQASGALFAALKQAVLEVSMELAQAIVRDGEGATKFVTVQVNGGATHQECLDVGYA VAHSPLIKTALFASDPNWGRILAAVGRAGVANLDVSKIDVFLGDVCIASRGGRAASYTEEQGAAVMAQAEIGIRI ELGRGTCSETIWTTDLSHEYVKINAEYRT Pseudomonas aeruginosa NYSGXRC-6252b SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC2480 GENBANK NP_069976.1 MEITDIGGVLCNGIKEGKYGLGLVRVRGSIAGVFTQNKIRAAPVIVCEENIRDGVVEGVIVNSGNANAYTGEQGMR DAREMCRIAANLLGCEERRVAVASTGVIGRKLDMEWIRKKAPEVYSGLGNSVENAERFGRAIVTTDRFVKKAYSE KARIAAVAKGAGMIAPNMATMLCFAFTSAKFDSGELYDMLRRAADKTFNRLTVDGDTSTNDTVLLISTGKERVER DVFEEELCSVFYSIAKQMARDGEGATKVFEVRVDGARNDEDANLIARAVASSLLVKTAIFGCDPNWGRIIAAAGY SGADVDERITLSLSDGRDEVFLIDSGRPLGNEERARVLMEKAEELVIRLRLEKGNGKGFAIGCDLTYDYVKLNAE YTT Archaeoglobus fulgidus NYSGXRC-6252c SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed Soluble EC2480 GENBANK NP_486113.1 MADWQEITGGITAPKGYRAAGITAGLKPSGLPDLALIVSDVEAIASGVFTTSQVKAACVDYCRQRLQAKQSARAIL CNAGQANAATGSQGIKDAEESAELLAKELNISPELILLASTGVIGQRIKMDALRNGIPKLIASLTDTGSDAAAGA IITTDLVTKSIALETTIGDRPVRIGGIAKGSGMIHPNMATMLAFVTCDAAVSSHLWQQMLTRAADRSFNSITVDG DTSTNDSLIALANGQSRTPAITEVGAESEKLEAMLTAVCQHLAKAIARDGEGATCLIEVQVTGAHDEQAARQIAK TIAGSSLVKSAIFGRDPNWGRIAAAAGRAGVPFEQENLQIQLGDFLLLDNGQPLPFDRAAASAYLKQAATGAYLQ QDTVLISVKVGNGHGTGKAWGCDLSYDYVKINAEYTT Nostoc sp. NYSGXRC-6252d SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC2480 GENBANK NP_357093.1 MSVAVSPLAPKSYPDMPALRGVRMATAAAGIKYKNRTDVLLMVFDKPASVAGVFTKSKCPSAPVDFCRANLGSGAA RAVVVNSGNANAFTGVKGKAATELTAKSAAAAVGCSEGEIFLASTGVIGEPLDASKFAGVLGDMNVRAEADFWQE AAKAIMTTDTYPKVSTRTAEIGGVIVTINGISKGAGMIAPDMATMLSFVVTDADIEPAALQSLLSAGVGPTFNSV TVDSDTSTSDTLMLFATGAAAEDGQVKVTSADDERLSSFRAALNDLLKDLALQVVRDGEGARKMVEVTVTGAEND AAAKKIALSIANSPLVKTAVAGEDANWGRVVMAVGKSGEMADRDRLAIWFGGVRVAVNGERDPDYSEAETTAVMR LEDITVKVDIGLGQGTATVWTCDLTKEYVAINGDYRS Agrobacterium tumefaciens NYSGXRC-6252e SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC2480 GENBANK NP_421860.1 VPFPTIPPIAGVEIATGRAGFYKHEREDLLLMRFAEGTSAAGVFTRHGVGSAPVDWCKRQLAATGGADVRALVVNA GCANSFTGKPGADAVRRVATAVGKRFDCRQRDVMMASTGVIGVILDDSKITARLPEVESRLKADAWAEAGRAIMT TDTFPKGAYATAVIDGHEVKIAGIAKGSGMIAPDMATMLAFVATDAAIAPAALQTLVSLYTRTTFNCVTVDGDRS TNDTLLLFATGQSGAPKIHRAGDKRLADFREKLEGVLLDLALQLVKDGEGATKFVKITVNGAESPASARKIARTI AESPLVKTAFAGEDANWGRIVMAVGRADEPVAREKISVKFGDLYAARDGLISAEYDEAKMSAYVKNQAFEVSVDV GVGRGSATVWTCDLTKQYVAINGDYRS Caulobacter crescentus NYSGXRC-6253a SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed Soluble Purified EC1013 ICEDB: T1944 GENBANK NP_417906.1 MSNWPYPRIVAHRGGGKLAPENTLASIDVGAKYGHKMIEFDAKLSKDGEIFLLHDDNLERTSNGWGVAGELNWQDL LRVDAGSWYSKMFKGEPLPLLSQVAERCREHGMMANIEIKPTTGTGPLTGKMVALAARELWAGMTPPLLSSFEID ALEAAQQAAPELPRGLLLDEWRDDWRELTARLGCVSIHLNHKLLNKARVMQLKDAGLRILVYTVNKPQRAAELLR WGVDCICTDAIDVIGPNFTAQ Escherichia coli NYSGXRC-6253b SGX Pharmaceuticals 2004-06-10 active Selected EC1013 MMPSIIVGHRGVAGTYPENTRVSVQAAINLGLSWVEVDVQPTKDNVLVVCHDHTIDRCSNGKGRIDEYTLAELKQL DFGAWFDPRFAGETIMTLEELLVLAAEHDLGLNIEVKVDKHDVASVVQQLKAQLDQSPLVADKILLSSFSHDIIL QLHQHCPGYKLGILSERLTQRDRQVLKQVNAFSCNLNYRWITEKHIRDLKNGGYQIWCYTLNQVDKFRYLDKVDA IFSDFPERFIN Vibrio cholerae NYSGXRC-6253c SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC1013 MSNWPYPHIVAHRGGGKLAPENTLAAIDVGARYGHTMIEFDAKLSKDGEIFLLHDDNLERTSNGWGVAGELNWQDL LRVDAGGWFSGEFKGEPLPLLSQVAERCRKHGMMANIEIKPTTGSGRLTGRVVALAARELWAGMTPPLLSSFEIE ALEAAQAAVPELPRGLLLDKWREDWRELTTRLGCVSLHLNHKLLDETRVQEIKAAGLRILVYTVNQPQRAAELLR WGVDCICTDRIDDIGPHFQF Salmonella typhi NYSGXRC-6253d SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed EC1013 GENBANK NP_294265.1 MPLLLGHRGSPREHTENTLASFQAALDAGLDGIELDVRRLADGTLAVHHDAALPDGRQLPHLTRAELPERVPTLPE VLAWAVDCEAYVNLELKWESPLPDDRVVRMLDSIRVHGLSRRVIVSSFNPLLLRAARELAPEVERGLLYHRPYRL GPLNLPEAVGRWVDCAALHPQHQLIDAPLISMARRRGWRVNAWTVNEVADVQRLAALGVDGLIGDVPAHLLPAR Deinococcus radiodurans NYSGXRC-6254a SGX Pharmaceuticals 2004-08-12 active Selected Cloned Expressed Soluble EC1033 GENBANK NP_415802.1 MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPE ELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYI TFGDDHFVPWWVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIV AIADPTAWIAEGSKLDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFF AATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLD IVAEPRRNANRIVEEAMIAANIGAARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCK LRRELDAQPTGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKRVIKGETATRPQDE ITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDEL VCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA Escherichia coli NYSGXRC-6254b SGX Pharmaceuticals 2004-07-09 active Selected Cloned Expressed Soluble EC1033 GENBANK NP_233191.1 MFQDNPLLAQLKQKIQETLPKKEGTIKASDKGFGFLEVDSKTSYFVPPPYMKKCMHGDKVVAFIRTENEREVAEPS ELIEQSLTRFIGRVKLFKGKLNVAPDHPQLKKLSLKAKTKKGLNEADFQEGDWVVAHLVRHPLKGDDGFFVQISH KITDANDKIAPWWVTLAENDLPNSEPAGIDDWQLKDDADLVREDLTALPFVTIDGESTKDMDDALYAQQLPNGDF ALTIAIADPTAYITPEDEMDKVARERGFTIYLPGRNIPMLPRDLADELCSLMENQVRPALCCSVTIRKDGVIGDD IRFFAANIKSHARLVYDHVSDWLETGSSEQWQPSEEIAQVVRDLYAFSQARANWRETHAVVFPDRPDYRFELSAD NDVVAIHADMRRTANRLVEESMITANICAGKTLQTTFGFGVFNTHAGFKAEKMADVVELMAVNGAPNADAETLAT VEGFAALRRWLATQETSYLDNRIRKYQSYSEIGNQPLPHFAMGLDVYATWTSPIRKYGDMINHRLLKAHILGKAP VQTPDETVGEELALHRKHHKIAERNVADWLYARTLADEPAKETRFQAEIFDINRPGMRVRLLENGAMAFIPGALI LDNKERIECNGEDGTVLIDKEVVYKLGDVLEIVLTEVNQENRSLVGKPTQVFADLVSETQTSAEQPAEGAENNEP QV Vibrio cholerae NYSGXRC-6254c SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC1033 GENBANK NP_354309.1 VSKAPRQRQGSASDGFGRTGRGKRVSEGEGIIHGEVPSREVLLKFIADHPQQASKREIAKAFGLKGENRIVLKALL KELEVDGMVHKSRKSLTRPGGLPPVTVLDITTRDKDGELIGRPAEWPEDMGAAPAVLIRQSSQDRGKKAPAAGLG DRILAKIFPSKDTVGPAYTARVVKLIDRRQNALLGVFKQTEGGGGRLMPIDRRGEEMVIDPDGVGDAKDGDLIEV ETSRNSGRYGLTRAKVLSVVGSVASEKAISMIAIYAHGIPHIFPPNVLAEADAAKAATMSHREDWRDLPLITIDP ADAKDHDDAVYAELDPSPDNPDGVIVTVAIADVSWYVRPGAPLDREALKRGNSVYFPDRVVPMLPERISNDLCSL KEGVDRPALAVRMTFSKEGRKASHTFHRIMMKSAAKLSYQQAQAAIDGNPDDKTGTLLEPILKPLWHAYEVMKRG RDRRQPLELDMPERKIQLRPDGTVDKVVIPERLDAHKLIEEMMIQANVAAAETLETKKQRLVYRVHDAPTLSKQE VLREFLGTIGISMAKGVAMRANSFNGILARALDTPHQIMVNEMVLRSQSQAIYSPENIGHFGLNLMKYAHFTSPI RRYADLIVHRALVGSLGLGEGGITPQEEATLDDIAAEISTFERRAMAAERDTVNRLIAHHLSERVGEEFEGRVGG VTKAGLFVALPQFGADGFVPISTLGTDYFFYDEAHQALTGEKTGLGYQLGDTVQVRLAEAVPLAGALRFEMLSPG RKMPVGSRSFHKAGRRTSRPGAKPGTRPPRGRR Agrobacterium tumefaciens NYSGXRC-6254d SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC1033 GENBANK NP_439875.1 MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPEA LIEPMLTRFIAKVRFNKDKKLQVLVDHPSINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQLI CRADDELAPWWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGW KLVVAIADPTAYIALDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLTGNITAK PHFVSAYVQSKAKLAYNKVSDYLEQADNAWQPEMPETAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYAFVLAEN GKVQEIKAEYRRIANQIVEEAMIIANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAE RYSVENLATLNGYCQMRHDIEPIESDYLELRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLI KAVLAKQPYEKPQNDVLARLQEARRQNRLVERDIADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGAS LFIPAATLHNNKEEIQLNPDELALYIKGERTYKIGDMVKVKLTEVKEATRSIVGEILQ Haemophilus influenzae NYSGXRC-6254e SGX Pharmaceuticals 2004-08-12 active Selected Cloned EC1033 GENBANK NP_214403.1 MDKEKLEKEVIKLLSKKKKPLHFLQIAKALGLGKKERKTLKKVMRKLKKEGKVKVVKGKYEYTGEEVVTGTVIAYP GGFGFLEVEGGKDIYIPPFEMVKVFHGDVVKAKVTEFKGKKEVRIIKVLKRAKKDIVAKVVFEDEQCYVVPLDEN AHHRILLSKKDCQKLKEGEVVVLKITQFPTKKSPARGKVIEVLGNPKEKFIAIDVIIRKYNLPTSYPEKVIKEVE AIPEEIPEEEIKRRRDLREQLCFTIDPEKAGDFDDAVAIELTPEGYYKLYVHIADVSYYVREGTETDKEAYKRGF TYYFPDRALHMLPEKLSAKLCSLRPNEDKLAFTVEMVFDESGNLKAYDIYESVIRSKARLTYNEALALIVGDPAL EKKFPNLVEPLRMMETLYRILSRKRWEMGSIDFDLPEAEVIVDEYGEPTAIYPYERHVAHRIIEHFMISANETVA LHLEHAGYPCLYRVHEPPDEEKVENLLEILEGLGYKVKRPHEYTPKFFQKIIEDFEGRPEENLVRFLTLRAMARA KYSPHNVGHFGLALEHYAHFTSPIRRYPDIIVHRLLKKALRGEEIDYEKTLAYLEEAGNHLSKQERIADEAEMEA IDYLKARYMKGRIGEEFIGIITGVVAFGFFVELEENLVEGLVKINTLTDDEYVFDEPAHRLVGVRTGKVFRLGDH VKVRCIAVDEERARVEFELIEKLEKHETL Aquifex aeolicus NYSGXRC-6254f SGX Pharmaceuticals 2004-09-15 active Selected Cloned Expressed EC1033 GENBANK NP_274225.1 MNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELSITEDEYVFFERRLKAMARDGQ VLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAKDGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGT VLDIVERAQSKVVGRFYMDRGVAILEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEV LGDYADSGMEIEIAVRKHHLPHQFSEACAKAAKKIPVHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEKV GRNYRLVVAIADVSHYVRPDDVIDADAQERSTSVYFPRRVIPMLPENLSNGICSLNPDVERLCMVCDMVVTYAGN IKEYRFYPAVMRSHARLTYNQVWKWISDGIDHPYKAQIDTLYKLFKILQKKRFERGAVEFESVETQMIFDDNGKI EKIVPVVRNDAHKLIEECMLAANVCAADFLLKNKHTALFRNHLGPTPEKLATLREQLGLLGLQLGGGDNPSPKDY AALVEQFKGRPDAELLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTPK KSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEVFEGKISGMTSFGIFVTLDGIHIDGLVHISDLGEDY FNFRPEIMAIEGERSGIRFNMGDRVAVRVARADLDDGKIDFVLIAGGSGRGRKVKSSASAKPAGTAGKGKPKTAA EKKTARGGKVRGRGASAAAESRKKAKKPVPIKVKKRKGKS Neisseria meningitidis NYSGXRC-6254g SGX Pharmaceuticals 2004-09-14 active Selected Cloned EC1033 GENBANK NP_488490.1 VEKGTLVEFRVQGDRRLGVVDRPDGKTRWFVVDERGQSHSLAPRQITYTVNGNTYKPSEIDRFLEEVKPYLDPSSL EVAWELLVEDGETVTPSQMANLLFSESNSAPSYAAHCLLSDDKLYFKQKGDAYEPRTAAQVADRKHQIEVEALKA RGQQEFLTRVEQALQGEAVEWQRHDRQRLEGLEKYGTLLADIVKVGLNYDSLARAYPPPAPVLETMNMLGRPATP QGAFQLLVDLGWWSATENLFLRRSSIPVQFPSKVLEVAQQRLDFPPTDLDTNRLDLTHLKVYTVDDESTTEIDDG LSWEKLPDDRERLWVHIADPTRYLAPEDDLDLEARKRGSTVYLPTGMIPMFPEVLATGPMSLVQGRVCCALSFGV VLDGTGAVQDFTIHPSLIKPTYRLTYEDVDEMLELGVQAEPEIAAIATWATKRKSWRYNQGAISINMPEAMIKVK NDDISIDILDDSRSRQLVAEMMILAGEVAARYGQVHNIPLPFRGQPQPELPPEDELLRLPAGFVRACAMRRCMPK SEMSITPVRHAGLGLDTYTQATSPIRRYSDLLTHFQLKAHLRGEVPPFTAEELKEVMMTVTSTTQELTMVERQTN RYWALEYLRRHPEEIWQVTVLMWLREDSNLALILLEDLGLQLPMVFKRSVRLGEQVLVKVSISDPQKDVIQFQEI IYQEAQTAAN Nostoc sp. NYSGXRC-6254h SGX Pharmaceuticals 2004-09-02 active Selected Cloned Expressed Soluble Purified EC1033 ICEDB: T1945 GENBANK YP_014560.1 MSEDLFDVEVRNFEEGDKVTGTVTSVEDKQVYVGIPGSKLDGVVPISELSNIHVETASDVVSVGDTLDLIVTKVED DILVLSKRKVDAEKASDDIKAKFESGEVFEAVVSDVVKGGLVVDLGVRAFVPASLVEDHFVEDFADYKGTTLTFK VVEFEPENNRVILSHRAVVETEKASQKQALLSEIKEGDVIEGTVQRLANFGAFVDIGGVDGLVHISQISYKHIAT PQEVLEEGQKVTVKVIGIDPENERISLSIKATLPGPWDGITEKAQVGSVLEGKVVRLVTFGAFVEIFPGVEGLVH ISQISHEHIGTPQEVLSEGQTVEVKVLEVNEADKRLSLSIKELQDAPVEEADYELPEENTGFQMSDLIGDKLKGL QNDDK Listeria monocytogenes NYSGXRC-6254i SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble EC1033 GENBANK NP_421256.1 MAKLRPTKTFKPKPPAGLPDRETLLAFLRDAGETGKADIARHFGLKGADRRALREMIRELEAQGALAKRGRKGFAE AGSLPPVGVADVVERDGDGELYVKLTKSDDDVPNVRLAPGKGEAAAGAPGLGDRLLVRFERLETGEFEAKLIKKL GQSAHKILGVIRKHRREVRVEPVDRKSKESLVLDPSVAHDFKEGDLVLAQVGTHGGRYGPKPGKVLEVVGTENDP RAASLIAIHSHGIPTGFSEAAEAEAKTAVEPTLAGREDLRDLPFVTIDPVDARDHDDAVYAHPDEDETNKGGFVV WVAIADVAAYVRPGSALDRDAREKGNSVYFPDRVEPMLPETLSNGLCSLRESENRATLAVRMVFDKSGRKKGHRF VRGLMRSAAKLSYEQAQAAIDGQPDDKAGPLLDPILKPLWDAYRTMKIGRDARSPLAIESDERRIIIKGGEITSI TKRASLEAHKLIEEMMVQANVCAAESLEAKRSPLIYRVHDTPSLEKVQNLADFLQTLEIRWSKGEAPQTARFNKL LEETRESPNAAIINEVVLRTQMQAHYSADNIGHFGLNLAKYAHFTSPIRRYADLIVHRGLIRALGLGTDGLTDQD IAQIKDTAEVITHAERRAMAAERDATDRYIAAFLADRVGATFEGRITGVTRFGLFIKLADTGADGLVPVSSLGQE FFVHDDKMHALVGERTGKRWPLGLSVEVKLVEATPVTGGLLFEMLSEPLPPDPKMPRPRLGARRQAAVKPRGGLP KGVRRGKRR Caulobacter crescentus NYSGXRC-6254j SGX Pharmaceuticals 2004-06-10 active Selected EC1033 MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPE ELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYI TFADDHFVPWWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTV AIADPTAWIAEGSKLDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFF AATIESKAKLVYDNVSDWLENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLD IVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCK LRRELDAQPSGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQED ITQQMAERRRLNRMAERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDEL VCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA Salmonella typhi NYSGXRC-6254k SGX Pharmaceuticals 2004-06-10 active Selected EC1033 LSTLQKNKLNQPTYPIPSREEILGVLRTSGSPLSAADIAKALSVTRKEHDGFIKRLTAMERDGQLELNRKGRYELA HQPNFIEGRVVGHRDGYGFFIRDDGEPDIFLPEREMQKAMHGDRALVRVIGYDRRGRSEGQIVEMLERANRYVIG RLLSESGTLVVAPEDKRLGRDILIAPKGQGKAKVGQVVSVEILEYPDRYVQPIGRVVEVLGEIDDPGMEIEIAVR KYGVPHEFSEATLRESEALPDVVRESDLAGRIDLRDVPLVTIDGEDARDFDDAVYCEPVKIGRSKGWRLVVAIAD VSHYVQPGKSLDVDAIDRATSVYFPRRVIPMLPEKLSNGLCSLNPEVDRLCMVCDAVITAKGQIKAYQFYPAVMH SAARLTYNEVWSILSNVKGPEAAKRAPLVPHLQDLYELFQVLLKARRERGAIDFDTTETYIVCNAQGKIEQILPR TRNDAHRLIEECMLTANVCAAEMLERYKHPALYRVHAGPTEEKLQALRAFLKTSGLTLGGGDKPQAADYAELMEK IIARPDAPMLQTMLLRSMQQAVYSPDNVGHFGLAYEAYAHFTSPIRRYPDLLVHRAIKAVLQHSRYVPALASGVQ LNSGLSPKARRMQAEADKATPAAVASKAKVEAIWHELGVHCSANERRADEASRDVEAWLKCYFMRDKLGNEFSGT VSAVTSFGIFVQLDELYVEGLVHVTELGSDYFQFDEARNELRGERTGIRYRLTDRVRVQLLRVDLDARKMDFRLI QEPSVKALRPAKVAGVPAEGAPRQPAVATPAPPVGRKKPRQLAALLGGTAKPEESFDETLDRVFEEQPVFEPGPR ALPPGHAHAKPTRKKPAARTTKPKTGGKTATRKAPGKTVRSRKGR Ralstonia solanacearum NYSGXRC-6255a SGX Pharmaceuticals 2007-01-25 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC3730 ICEDB: T1946 PFAM PF03009 PDB 2P76 PDB 2OOG GENBANK NP_371483.1 MTNSSKSFTKFMAASAVFTMGFLSVPTAGAEQTNQIANKPQAIQWHTNLTNERFTTIAHRGASGYAPEHTFQAYDK SHNELKASYIEIDLQRTKDGHLVAMHDETVNRTTNGHGKVEDYTLDELKQLDAGSWFNKKYPKYARASYKNAKVP TLDEILERYGPNANYYIETKSPDVYPGMEEQLLASLKKHHLLNNNKLKNGHVMIQSFSDESLKKIHRQNKHVPLV KLVDKGELQQFNDQRLKEIRSYAIGLGPDYTDLTEQNTHHLKDLGFIVHPYTVNEKADMLRLNKYGVDGVFTNFA DKYKEVIK Staphylococcus aureus NYSGXRC-6255b SGX Pharmaceuticals 2004-06-28 active Selected Cloned Expressed EC3730 GENBANK NP_721147.1 MTQIFAHRGSKVDCPENTLAAFKKAIQVGCDGIEIDVHRTKDNQLVVIHDEAVDRTSNGSGLVRQLTLKQIRMLDA GSWFHPAYFCEKIPTLEEVLNFLEESGFQGTLNLEIKTNRYPYPKIEKQIAQTMQAKKRSFSHIYSSFNLFSLYV MRKHDPKAELAYLMKFHPFHFWLAQQLKFIKTVHSHSSFYENQVTKRKNKKPFRLWTVNNDDDMKKFFLSGIEGI ITDKPEEAVKLRKSLQTKKE Streptococcus mutans NYSGXRC-6255c SGX Pharmaceuticals 2004-06-10 active Selected EC3730 MKTTLKNLSVALMLAGMTIGSGAVAAEKVVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDHLVVLHD HYLDRVTDVADRFPDRARKDGRYYAIDFTLDEIKSLKFTEGFDIENGKKVQTYPGRFPMGKSDFRIHTFEEEIEF VQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYIGKQDNVYLQCFDVAELKRIKNELEPKMGMD LNLVQLIAYTDWNETQQKQPDGRWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLVAEGSTKGNIKLTGMVQDAH QNKMVVHPYTVRADQLPDYATDVNQLYDILYNKAGVDGLFTDFPDKAVMFLQKND Salmonella typhi NYSGXRC-6255d SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC3730 GENBANK NP_422066.1 MTLLTRRALTTAALAGTFLPGLARAQSRKPIVIGHRGCSGERPEHTALAYERAIEQGADFIEPDLVPTKDGHLVAR HENEIGGTTDVASRPEFAARKTTKTIDGEQITGWFTEDFTLAELKTLRARERLPQLRPASAAFDGQAQIPTFEEV WAIAQAGSKRTGRTIGVYPELKHPTYFAAIGLPTEARLVTKLKALGLNSATAPVFVQCFEVAPLKRLRALTSARL VFLVDAEGGPADQPGVKYADLITAQGLKDVAVYADGLGPNWKLVVPHDGQVLGAPTTLVRDAHAAGLAVHPWTVR SENAFLPVSLRKGDPASPGFLAQHGDSEAVLKALYAAGVDGVFSDFPALAVAARG Caulobacter crescentus NYSGXRC-6255e SGX Pharmaceuticals 2004-09-15 active Selected Cloned Expressed EC3730 GENBANK NP_485094.1 MRHFFGAFLLGMATLTVMPTEQVLAGTLTGQPPIVIGHRGASGYRPEHTLAAYELAIQMGADYIEPDLVATKDGVL VARHENALAILNADGTLNLTDTSTDVFERLQFADRKTTKVIDGRSITGWFTEDFTLAELKTLRAIERIPGIRPQN TQYDRQFEIPTLQEVIDLAKAQSAALGRTIGIYPETKHPTYFDSIGLSMEEILVSVLNANGYVDESAPVYIQSFE VSNLKDLNRLTNVSLVQLISPSGRPYDFVVNGDSRLYRDLITPLGLAEIATYANGIGANKNLIIPRDGRGNLLSP TTLVDDAHAAGLIVHAWTFRNEDVFLPTNLQGNPQEEYKRFYQTGIDGLFSDNPDTAFAVRSTLVPEPGTIFGLG FVPLLGWLFRRRK Nostoc sp. NYSGXRC-6256a SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC4651 MPAIQSELDVNGEDFARNREAMLAAVAGFRELEQKVLDKAAEARPKFEKRGQLLPRERLALLLDPGAPFLELSSLA GYKLHDDKDGTQAGGGIIAGIGYIAGVRCLVSASNSAIKGGTISPTGLKKTLRLQQIAMENKLPVVTLTESGGAN LNYAAEIFVEGARGFANQARISAMGIPQVTVVHGSSTAGGAYQPGLSDYVVVVRGKAKMFLAGPPLLKAATGEIA SDEELGGAELHAQVAGTAEYLAENDADGVRLAREIVGMLPWNAQLPARPARSWREPLYPVEELLGVVPADPKKPY DVREIVARIADGSEFLDFKNEFDGQTVCGHLRIEGHACGLIGNNGPITPQGAAKAAQFIQLCEQSNTPLLFLHNT TGFMVGTESERQGVIKHGSKMIQAVANARVPKLTLVVGGSYGAGNYAMCGRGLDPRFIFAWPNSRTAVMGGAQAG KVLRIVTEEKHAKEGKEADPKMLEMLETVTAQKLDSQSTALYGTASLWDDGLVDPRDSRRLLGYLLDICAEAEAR PLKGNSFGVARF Pseudomonas aeruginosa NYSGXRC-6257a SGX Pharmaceuticals 2004-08-12 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_285879.1 MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTL DYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAE RFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYS VISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLS TEDLKNRRYQRLMSYGYA Escherichia coli NYSGXRC-6257b SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_421789.1 MAAHYLDFERPIADLESKIEELSRLSETAGPGAFDTEIQALRDRAQELRKEAYANLDAWQKTMVARHPQRPHLRDY VAGLIDEFVELRGDRKFADDQAIVGGLGRFRGQPVVVMGHEKGHDTTTRLKHNFGMARPEGYRKAVRLMDMAERF NLPVITFVDTAGAYPGLGAEERGQAEAIARSTERCLTLGVPMVATIVGEGGSGGAIALAGANRVLILEHSIYSVI SPEGAASILWRDGARAKDAATQMRITAQDLIKLGIVDRIVEEPAGGAHSDTEAAIQAVGDAVEDELKAMAAMSPA ELKKQRSDRFYAIGRAGLQ Caulobacter crescentus NYSGXRC-6257c SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_269766.1 MTDVSRILKEARDQGRLTTLDYANLIFDDFMELHGDRHFSDDGAIVGGLAYLAGQPVTVIGIQKGKNLQDNLARNF GQPNPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIAKNLMEMSDLKVPIIAIIIGEGGSGG ALALAVADQVWMLENTMYAVLSPEGFASILWKDGSRATEAAELMKITAGELYKMGIVDRIIPEHGYFSSEIVDII KANLIEQITSLQAKPLDQLLDERYQRFRKY Streptococcus pyogenes NYSGXRC-6257d SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC1570 GENBANK NP_438568.1 MNQEYLDFELPIAELEAKIEALRAASDDKVDLTDEIKRLQKKSNELTKKTFANLDAWQVSRMARHPNRPYTLDYIE HIFTEFEELAGDRAFADDKAIVGGLARLDGRPVMVIGHQKGRSVKEKVQRNFGMPAPEGYRKALRLMEMAERFKL PIITFIDTPGAYPGIGAEERGQAEAIARNLREMAQLTVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISP EGCASILWKSAEKASTAAEVMGLTASRLKELNLIDSIVQEPLGGAHRSYLEIAENLKLRLKEDLAELDELSKEEL LNRRYERLMSYGYC Haemophilus influenzae NYSGXRC-6257e SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC1570 ICEDB: T1947 GENBANK NP_244031.1 MSTELDFEKPIRDLKGKIEELRTFTEEKEIDLSDEIEKLEKRLHALEENIYGNLKPWQRVQIARHGERPTTLDYIE QLFSDFLEMHGDRLYGDDEAIVAGIAKYKGQPVTVIGHQRGKDTKENIRRNFGMPHPEGYRKALRLMKQAEKFHR PVICFIDTKGAYPGKAAEERGQSEAIARNLLEMAGLKVPIVCIVIGEGGSGGALALGVGDRIHMLENSTYSVISP EGAAALLWKDASQAQRAAETMKITAPDLKELQIIDDIIPEVRGGAHRNVAEQAEAIDQVLEKSLKQLSSLTTEEL LNKRYEKYKKIGEFSHVNDAISVN Bacillus halodurans NYSGXRC-6257f SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_722061.1 MSDVSRILKEARSQSRLTTLDYAEQIFDDFMELHGDRHFADDGAIVGGIGLLDGQAVTVIGVQKGKNLQDNLNRNF GQPNPEGYRKALRLMKQAEKFKRPVVTFINTAGAYPGIGAEERGQGEAIARNLLEMSDLKVPIIAIIIGEGGSGG ALALAVADKVWMLEHTMYAVLSPEGFASILWKDGSRSIEAAELMKITAGELLKMEVVDKVIPEHGYFSSEIIQML KTNLIEELKNLDQYPLNDLLEKRYQRFRKY Streptococcus mutans NYSGXRC-6257g SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed Soluble Purified EC1570 GENBANK ZP_01067288.1 MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDA HEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVAGLAEKFQIPILFLI DTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADKLAMMKNSVFSVISPEGCAAI LWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQ KILKLGAYQEA Campylobacter jejuni NYSGXRC-6257h SGX Pharmaceuticals 2004-08-20 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_816495.1 MEKKTANDVVTLARAQDRLTTLEYIEAIFEDFLEFHGDRYFADDLAVVGGVATLQGKPVTVVGIQKGRNLPENIER NFGSPNPEGYRKALRLMKQAEKFNRPVITFVNTAGAYCGIGAEERGEGEAIAQNLLEMSDLKVPIISVIIGEGGS GGALALAVADEVWMLEHTIYAVLSPEGFASILWKDGSRAKEAAELMKITATELKELAIVDKVIPEVMNGQPLEQA KINRMLQKAFISKLTELAKLDTETLLEKRYQRFRKY Enterococcus faecalis NYSGXRC-6257i SGX Pharmaceuticals 2004-08-20 active Selected Cloned EC1570 MHNYLDFEKPISDLEGKIIELKKLADEDESIDTSEEINRLESRVNDAMQDIYSKLNAWQKTQVARHPQRPHFVDYA KSLFTDFTPLAGDRKFSEDAAIQAGLARFNGQPVAIIGQEKGNDTKSRLKHNFGSARPEGYRKAIRVLELADRFS LPVVTLIDTAGAYPGVGAEERGQAEAIARSTEMCLNVKVPIVSVVIGEGGSGGAIAIATGNRVYMLEHSVYSVIS PEGAASILWRDSTRAKEAATNMKITSEDLKSLGVIDGIIPEPIGGAHRAPETVISATGDVIAKALADLSQRSGTQ LRAERRQKFLDIGRNL Agrobacterium tumefaciens NYSGXRC-6257j SGX Pharmaceuticals 2004-08-20 active Selected Cloned EC1570 GENBANK NP_465097.1 MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLESSIYSNMTAWDKFQVARHPERPTTLDYIS LLFEDFMELHGDRTFGDDAAIVGGIATFKGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGR PIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISP EGAAAILWKDASLAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLTAQAEEINKTITKSLHALMAFSEEQL IKQRYEKFKKIGVYETI Listeria monocytogenes NYSGXRC-6257k SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_231875.1 MSLNFLDFEKPIVELETKIQALRDVSRHSTSASVDLDKELEQLEKKSLELKKKIFSDLGAWQVAQLARHPQRPYTL DYLKHIFTEFDELAGDRAYADDKAIVGGIARLEGRSVMVIGHQKGRETREKVKRNFGMPKPEGYRKALRLMEMAE RFNMPIITFIDTAGAYPGVGAEERGQSEAIAKNLKVMSGLKVPVICNVVGEGGSGGALAIGVGDYVNMLQYSTYS VISPEGCASILWRDSDKAPQAAEAMGLIAPRLKELELIDEIIEEPLGGAHRDHKQTAENVKATLLRQLADLDALD HENLLERRYQRLMNYGYC Vibrio cholerae NYSGXRC-6257l SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1570 GENBANK NP_357981.1 MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFG QPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGA LALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVK KELQTELARLSQKPLEELLEERYQRFRKY Streptococcus pneumoniae NYSGXRC-6257m SGX Pharmaceuticals 2004-08-12 active Selected Cloned EC1570 GENBANK NP_213824.1 MILFKVMHLEFEKELLEIKEKIDRLLGLYRLGKEEVLSELDELRKKFKEKARKIYRDLSPWERVQVARHPKRPHTS DYIKYLIKDFEEVHGDTCYGDDKAVIAGFGYFRGKPVAVVGHEKGKDTKEKLERNFGMPHPEGYRKAIKVFKLAE RYNIPVITFIDTPGAFPGIGAEERGQSRAIAESMLTMAFLKVPSVAVVIGEGGSGGALAFGVANRVCILENAYYS VISPEGCAAILWKDQSKVKEAAKALRLTAKDLKELGVVDCVIPEPYGAAHWSPRGTAMMVGMTLKKCLDELSKLT EEGVVRSRLEKFKNMGAFKIAS Aquifex aeolicus NYSGXRC-6258a SGX Pharmaceuticals 2004-08-20 active Selected Cloned EC1540 GENBANK NP_207147.1 MDRAKFIFVTGGVLSSLGKGISSSSIATLLQHCNYQVSILKIDPYINIDPGTMSPLEHGEVFVTSDGAETDLDIGH YERFLNRNLTRLNNFTTGQIFSSVIENERKGEYLGKTIQIVPHVTDEIKRRIKSAAKGLDFLIVEVGGTVGDMEG MFYLEAIRQLKLELGNEKVINVHVTLIPYIQTTNELKTKPTQHSVQELRRLGVTPQIILARSPKPLDKELKNKIA LSCDVEQDSVIVATDTKSIYACPILFLQEGILTPIARRFNLNKLHPKMAAWNTLVEKIIAPKHKVKIGFVGKYLS LKESYKSLIEALIHAGAHLDTQVNIEWLDSENFNEKTDLEGVDAILVPGGFGERGIEGKICAIQRARLEKLPFLG ICLGMQLAIVEFCRNVLGLKGANSTEFNQRCEYPVVYLIGDFMDQNHQKQVRTYNSPLGGTMRLGEYECEIMPNS LLEKAYKKPSIKERHRHRYEINPKYRQEWENKGLKVVGFGSNHLIEAIELEDHPFFVGVQFHPEFTSRLQSPNPI ILDFIKSALSKS Helicobacter pylori NYSGXRC-6258b SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed EC1540 GENBANK NP_439233.1 MATNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTQDGAETDLDLGHY ERFIRTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHITNEIKDRVIAGAQGHDVVIVEVGGTVGDIESL PFLEALRQLAVQVGREHTLFMHLTLVPYIPTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMIPPNERAKIAL FCNVAERAVISLKDVNSIYQIPALLKSQGLDDFVCERFRLTCPEADLTEWEQVLYKQANPVGEVTIGMVGKYTEL PDAYKSVNEALKHAGLTNRLSVNIKYIDSQDVETKGVEVLKGIDGILVPGGFGYRGVEGKIRTAQYARENKIPYL GICLGMQIALIEYARNVAGLTKANSSEFDKDCEQPVVALITEWQDAEGNTEVRTDESDLGGTMRLGAQQCHLVSG SRARELYGKETIEERHRHRYEVNNTLLPQIEKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGH PLFAGFVKAAYENHKKSVK Haemophilus influenzae NYSGXRC-6259a SGX Pharmaceuticals 2004-12-02 active Selected Cloned Expressed Soluble Purified EC260 ICEDB: T2210 GENBANK NP_229090.1 LKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENYRKNVDVIPSNELSYYDFVLDTAVMVGA VPERFGEYRGLSTYFDMARGGKALEMTKFFNTNYHYLVPEIETEEFYLLENKPLEDYLFFKSKGIETAPWVIGPF TFLYLSKRNGEWIRRPNQMEKLLESLVSVYKEVFEKLVENGCKEILVNEPAFVCDLEKAHWDLILNVYRELSEFP LTVFTYYDSVSDYEACVSLPVKRLHFDFVSNEENLKNLEKHGFPEDKKLVAGVINGRQPWKVDLRKVASLVEKLG ASAISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEKLEELKMLKDFLEGKTFDLPNVSFEDFAVDLQAVERVRN LPEDSFRREKEYTERDRIQRERLNLPLFPTTTIGSFPQTPEVRKMRSKYRKGEISKEEYEAFIKEQIKKAIELQE EIGLDVLVHGEFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPIIYGTVTRPEPMTLKEITYAQSLTEKPV KGMLTGPVTIMSWSYYREDIPEREIAYQIALAINEEVKDLEEAGIKIVQIDEPAFREKAPIKKSKWPEYFEWAIN AFNLAANARPETQIHAHMCYSDFNEIIEYIHQLEFDVISIEASRSKGEIISAFENFKGWIKQIGVGVWDIHSPAV PSINEMREIVERVLRVLPKELIWINPDCGLKTRNWDEVIPSLRNMVALAKEMREKFES Thermotoga maritima NYSGXRC-6259b SGX Pharmaceuticals 2004-06-10 active Selected EC260 MTILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLL LGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEAL ALGHKIKPVLLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGVEWVQIDEPALVLELPQAWLDAFK PAYDALAGQVKLLLTTYFEGVTPNLDTIIVLPVQGLHVDLIHGKDDVVELHQRLPVDWLLSAGLINGRNVWRADL TEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSV PIQARRHSHRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGN LDANNYRTGIAEHIKQAIIEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDI SRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEP ALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLES FEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRLWVNPDCGLKTRGWPETRAALANMVKAAHNLR QAK Salmonella typhi NYSGXRC-6259c SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC260 GENBANK NP_419301.1 MTVTIATLGFPRIGPKRELKFALEAYWAGKTDADALLDTARDLRAKTWTRQAALGVAHVPSNDFSLYDHVLDTAVM VGAIPAAYGWSGGTVDLATYFAMARGDQGRPAAEACGPGCGHAPGADGVPALEMTKWFDTNYHYLAPELSPGQAF ALTSSKPVDEFLEAKALGVHTRPVLLGPVTFLKLAKTKAEGFSPLSLLSALLPVYGQVLRGLAAAGADWVQIDEP CLALDLTDFERAELRRAYGALTHAAPGVRLMLTSYFGGYGENLATAVNLPVEGLHLDLVRAPDELEAALAASRES LVLSLGVIDGRNVWRADLPALLDRLEPVVARRGSDRVVLAPSCSLLHTPIDLDLETALDPEIRQWLAFAVQKVEA LAVLAQALNGGRASVAAALEASAQAARARATSPRIHDPKVAERLAAVTPDMTRRRSPYDQRREAQRARLNLPPLP TTTIGSFPQTTEVRQARAAFAKGQISDATYEAFLRQETARAVAWQETVGLDVLVHGEFERNDMVQYFGEQLAGFA FTQSGWVQSYGSRCVRPPILFGDVSRPAPMTVDWWRYAQGLTRRPMKGMLTGPVTILNWSFVRDDLPRETACRQI ALAIRDEVVDLEATGAAIIQIDEAALREGLPLRRGDWDAYLDWAVESFRLAASGVADATQIHTHMCYSEFNDIIA AIGAMDADVISIETARSKMELLDAFVGYAYPAQIGPGVYDIHSPRVPAVEEMTTLLAAARQRLAGEQLWVNPDCG LKTRKWPETQAAIVNMVEAARRARAS Caulobacter crescentus NYSGXRC-6259d SGX Pharmaceuticals 2004-06-10 active Selected EC260 MTTIHTLGYPRIGAQRELKFALESFWKGASTEADLRDTGRALRERHWNAQRDAGLDFVTVGDFAWYDQVLQTAALL GALPTRYGFDPAQLTLAQSFVLARGNADHAAMEMTKWFDTNYHYLVPELTPDLRFGPGTGWLFDEVREAQAAGHR VKVALLGPVTFLHLAKARGGLADKLSLLPQLLPAYAAVLKRLAAEGVEWVQIDEPALVLDLPQAWSDAYGPAYAT LAAAGGPRLLLATYFEAASHHAALIRSLPVAGVHLDLVRAPQQLEAFAPWPADKVLSAGVVDGRNIWRTDLEQAL ARVAPLAQTLGERLWLAPSCSLLHVPVDLAAETRLDDELKGWLAFARQKLDELAVLKRAVIDGRDAAHAALAGSA AAIASRAASRRVHNDSVKKRAAAIRAQDAERAAPYPVRAAAQQARLNLPLLPTTTIGSFPQTAEIRQARAQYKRG ELQALTYLERMRAEIADVVQRQEALGLDMLVHGEAERNDMVEYFGELLWGYAFTANGWVQSYGSRCVKPPVIYGD VYRPEPMTVEWSRYAQSLTAKPMKGMLTGPVTMLQWSFVRDDQPREQTALQIALALRDEVRDLEAAGIAAIQIDE PAFREGLPLRAGDVAVYLEWAARVFRVSASGVRNDTQIHTHMCYSEFNDILPAIASMDADVITIETSRSNMELLD AFGEFAYPNEIGPGVYDIHSPRVPRVEEMEALLDKAAQVVPVQRLWVNPDCGLKTRGWPEVEAALRGMVEATRRL RARHAGAVHAGTPATRAEHAESALA Ralstonia solanacearum NYSGXRC-6259e SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble EC260 MVKSAVLGFPRIGKNRELKKATEAYWSGKTSAEELLATAKQLRLEHWKLQKAQGVDIIPSNDFSLYDQIMDHSFSF NVIPPRYRLSGLSSLDTYFAMGRGMQRAATADKAAVDVPAGEMVKWFDSNYHFLRPEVSEETDFKLSSTKALDEF LEAKEAGIITRPVLVGPVTYLFIAKAAKGSSIKPIELLPKLLPVYVELIKKLTEAGAEYIQIDEPILTLDLPQEI LASYKEAYETLGKIGKLILTTYFGSLQSNADVLKGLPIAGVHVDVVRAPENLDRALAVLGENQIISVGVVSGRNI WKTDFQKATAIIEKAISAVGSERVQVASSSSILHIPHSLSGEDQINPEIKRWFAFAVEKCAELAILTKAANDGPA SVRAELEANAADCKARAESPITNVEAVRERQSKVTPQMHERKSPFETRYAKQQASLKLPLFPTTTIGSFPQTKEI RVTRNRFAKGLISQEEYDAFIRKEISDVVKFQEEVGLDVLVHGEPERNDMVQYFGERMEGFVFTVNGWVQSYGSR CVRPPIIVGDVYRPAPMTVKESQYAQSITSKPMKGMLTAPITILRWSFPRDDVHDSVQAQQIALGLRDEVLDLEK AGIKVIQCDEPALREGLPLRRAEWDEYLKWAIDAFRLATAAVQDDTQIHSHFCYSDFNDIFDAIQRLDADVVSIE NSKSDMKLLNVLSRYTSCIGPGLFDIHSPRVPPVSEFKERIDAIVKHVPKDHLWLNPDCGLKTRGWPETTADLKN MIAAAREAREQYA Schizosaccharomyces pombe NYSGXRC-6259f SGX Pharmaceuticals 2004-07-12 active Selected Cloned Expressed Soluble Purified EC260 ICEDB: T1922 GENBANK NP_358108.1 LRRLLQVFFFCPKQIYSFKLYQSLIFYNYTDAFFSVKIVSTTNFGGHIMSTTIIGFPRLGEFRELKFTTEKYFRKE ISEEELLAAAKDLRAKHWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQGE KGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVGPFTFLQLSDFEEGVKADD FVDSFVAAYQEVFAKLADLGATRIQLDEAALVKDLTAEEKALFLNLYNKLLADKKGLEVLFQTYFGDVRDVYADL VNLPVDAIGLDFVEGKKTLELVKGGFPADKTLYVGIVNGKNIWRNNYEKSLTVLEQIPAENIVLTSSCSLLHVPF TTANEEFEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAGLTDADYTRLPA FAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKEYDAFLAETIDEWIKWQEDIDFDVLVHGE FERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTIL NWSFPREDISIKDSTLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVA PDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVGPGVYDIHSPRVPNEGEIDNTI EAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVEAAKAAREKL Streptococcus pneumoniae NYSGXRC-6259g SGX Pharmaceuticals 2004-09-01 active Selected Cloned Expressed Soluble EC260 GENBANK NP_465206.1 MVKAISSNLGYPRLGEKREWKRALEKFWNGAISEEELLAETKALRLHALKKQQEKGIDLIPVGDFSFYDQVLDTSV TFGIIPKRFQHDGGKVSLNTYFDIARGKSDAVASEMTKWFNTNYHYIVPELADADPKVLDNRALYYYEEAKKELG IEGKPVLVGPVTYLKLGKGNDAENFEALLDKFIPAYVEILKELERAGAKWVQIDEPYLATSFDKSEIKLFEKVYQ AFQTAVPNLKIELQTYFESLDYYEEVVNLPVAAIGIDFVHDHGDSLEALKAHGFPEDKYLAAGVIDGRNVWRSDL DAKLSLLTEIADYVTDGKLIVQPSNSLLHVPVTKLSEPDLDEVILGGLSFADQKLDEIAILTKALTDGAESVTAE LEDARAAVTALNESSHRNNLEVQEAIANLGNVRVDRELPFAERIKLQHAWLNLPLFPTTTIGSFPQSPEVRKTRA DWLKGNITDAEYNAFIEKETARWIKIQEELDIDVLVHGEFERTDMVEYFGQKLAGFQATKFGWVQSYGSRAVRPP LIYGDVAFTEEITVKESVYAQSLTKRPVKGMLTAPVTIINWSFVRDDVPESVVANQVGLALRKEVEALERNGIKV IQVDEPALREGLPLKQARWEKYLNDAVYSFKLTTASVQNDTQIHTHMCYSDFDDIIDTISALDADVISIETSRSH GEIISTFEEVTYDKEIGLGVYDIHSPRVPTVTEIQDNIRRALRAIDAKQFWINPDCGLKTRKEPETIAALQDMIK ATKEVRAEYQVLEK Listeria monocytogenes NYSGXRC-6260a SGX Pharmaceuticals 2004-06-10 active Selected EC698 MLKGPLKGCLNMSKKVIVIAGTTGVGKSQLSIQLAQKFNGEVINSDSMQVYKDIPIITNKHPLQEREGIPHHVMNH VDWSEEYYSHRFETECMNAIEDIHRRGKIPIVVGGTHYYLQTLFNKRVDTKSSERKLTRKQLDILESTDPDVIYN TLVKCDPDIATKYHPNDYRRVQRMLEIYYKTGKKPSETFNEQKITLKFDTLFLWLYSKPEPLFQRLDDRVDDMLE RGALQEIKQLYEYYSQNKFTPEQCENGVWQVIGFKEFLPWLTGKTDDNTVKLEDCIERMKTRTRQYAKRQVKWIK KMLIPDIKGDILLDATDLSQWDTNASQRAIAISNDFISNRPIKQERAPKALEELLSKGETTMKKLDDWTHYTRNV CRNADGKNVVAIGEKYWKIHLGSRRHKSNLKRNTRQADFEKWKINKKETVE Saccharomyces cerevisiae NYSGXRC-6260b SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble EC698 MLKPLCVVIGTTGAGKSDLAVQLAKRFGSQVINADSMQIYRGFDTITNKITVEEQENVHHRLMSFLNFDKEYSVPE FERDASRVIDEIHSQGKIPIVVGGTHYYLQSLLFEDTTLSAIDKLTNDSSPSKPPHPDSHILDDDPSAMLSYLKK IDPVMAEQWHPRDTRKIRRSLEIYFHTGRPPSEIYSEQKMKSSGSKLRYKSLIFWAFADSLVLMPRLDKRVDKML SHGLVDEIKSMKSLAESEKFSPDFTRGIWQCIGFKEFMPWFEAPSDIVFNDCLERMKVSTRQYAKSQKKWIQSRF LPMCLAQQDLSPSSILFSTTNTTDLNNWEEQVEKACRVFQYFFYNGDAIAPSADDQHAFEKARDYLSIMNGRQSQ KKKFVCEECLDKRGDPFTVIGEDAFNVHIKSRKHKTTVRRKKERAERQIRLKNIGILK Schizosaccharomyces pombe NYSGXRC-6260c SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble EC698 GENBANK NP_295413.1 MAAPLIPVLTAPTAAGKTALALRLAREYGLEIVAADAFTVYRGLDLGTAKPTPQERASVPHHLLDVVDVTQSYDVA QYAAQAEAAIVDILARGRLPLVVGGTGFYLSALSRGLPLTPPSDPKMRAALEAELQERGLDALLAEIEQANPAEA ARMERNPRRVVRALEVYRAAGRFPGEFGYSPPAFQYQVFAFSPPAAEMEQRVQERTAAMLRAGWPQEAQWLAGQV PPEQEPRPTVWQALGYAEALAVAQGRLSLAGAEQAIALATRQYGKRQLTWMRRQLGAEVQSPDAAEAHLRAFLER SGAPS Deinococcus radiodurans NYSGXRC-6261a SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1948 GENBANK NP_372437.1 VYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLK SIGYKDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIAS NDKLMEFGTRRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNC VFLVDTFHTLKSGVPNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSL KAQGAKVDSWGVGTKLITGYDQPALGAVYKLVAIENEEGSYSDRIKLSNNAEKVTTPGKKNVYRIINKKTGKAEG DYITLENENPYDEQPLKLFHPVHTYKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYLAQGLQSIWDENKR FLNPQEYPVDLSKACWDNKHKRIFEVAEHVKEMEEDNE Staphylococcus aureus NYSGXRC-6261b SGX Pharmaceuticals 2005-11-30 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC3078 ICEDB: T1949 GENBANK NP_816265.1 PDB 2F7F MDYTYADDSLTLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYL REVEEYPEDFLTYLANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSV IGDDPLLEFGTRRAQELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHR DCVFLVDTYDTLKAGVPSAIRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTIL NLKMQKSKIDVWGVGTKLITAYDQPALGAVFKLVSIEGEDGQMKDTIKLSSNAEKVTTPGKKQVWRITRKSDKKS EGDYVTLWNEDPRQEEEIYMFHPVHTFINKYVRDFEARPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEY KRDLNPQKYPVDLSTDCWNHKMNLLEKVRKDVKHLTETVNKEA Enterococcus faecalis NYSGXRC-6261c SGX Pharmaceuticals 2004-09-14 active Selected Cloned Expressed EC3078 GENBANK NP_215087.1 MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGL GQFSDEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAARG RPVVDFGARRAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATM LLVDTYDTLRGVDHVIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALLA ARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGENLP GDPLLVPIMTNGRRIRQHAPTLDGARDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAHP GSNVVGAKAKRP Mycobacterium tuberculosis NYSGXRC-6261d SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC3078 GENBANK NP_212769.1 MKNLSLFTDFYEISMMNAYFTKGINPKAKFEVFFRKTPFKNGYIVLAGMHTLINELKNIRFGENELKYLKSFNILD KQFLNFLREFKLNVKISSIEEGRIVFPQAPVVVIEGHLIELLLIEGLVLNIINFESLIATKTARIKESGAKILAE LGLRRAQGINGALSASKAAYIGGADFTSNMLAGYKYNIPVTGTMAHSWIMSFETEEQAFREYAKTYPNKVSLLID TYDTLNSGLKNAIKIFKELKHEEKNNFSIRIDSGDLEYLSKAARKELNRNGLNHVKIIASNELDENIIMYLNSIN APIDIWGVGTNLVTAKGDPSLSGVYKMISIEKNGKFIPKIKISNNAEKSTLPDQKEVARIYLNDQMILDFIFLKE EKDKIKDHLNSRKEFTVFHPIQDNIFKIIKQYDDFEFLTHTVLENGKLRKGYESSLTNIRNKTKLDLSKLEHTYK RIINPHIYKVSISKNLRKLKNKLTKDIKNN Borrelia burgdorferi NYSGXRC-6261e SGX Pharmaceuticals 2004-07-12 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1903 GENBANK ZP_01827738.1 MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVFAGLERIVNYLEDLRFSDSDIAYLESL GYHGAFLDYLRNFKLELTVRSAQEGDLVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDE PLMEFGTRRAQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYAATHKNCVF LVDTYDTLRIGVPAAIQVARELGDQINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLKM QKAKIDVWGVGTKLITAYDQPALGAVYKIVAIEDETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDY ITYDGVDISDMTEIKMFHPTYTYIKKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRVL NPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE Streptococcus pneumoniae NYSGXRC-6261f SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed Soluble Purified EC3078 GENBANK NP_347638.1 MEFKKNFDIKDDRNLTMLVDFYELTMGNGYLNKNVGNKTAYFDMFFRRVPDNGGYCIMAGVQQLTEYLSNLRFTKE DIDYLRSKHEFSEEFLSYLKDFKFECDVWAVPEGNPVFPNEPLVTVKGPAIQAQFVETMILLTINHQTLIATKAN RICRAAGNRPVMEFGSRRAQGYDGAIYGARAAVIGGCSSTACTISEQMFGVNAVGTMAHSWVQLFDNEFEAFKAW ADVYPENCVLLVDTYNVLKSGLPNAIKVFDEVLKPKGIRPSGIRIDSGDITYLTKKCRKILDEAGYSDCKIVISN SLDEHIITDVLLQGAEVDSFGVGERLITAKSEPVFGGVFKLCAVENDEGNIVPKIKISENQEKITNPGFKKIYRL FDKETDKALADLITLNDEVIDETKPLEIFDPIYTWKKKKLTHYYVKDLRVQLFKKGELVYENPEVLEIRNIAKKE TEKLWAEVLRLENPHTYYVDLSKKLWDLKHNLLEKYSNAFNS Clostridium acetobutylicum NYSGXRC-6261g SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC3078 GENBANK NP_579633.1 MKRFYIANEDEIKAGKTTDVYFLRTKKILEVKNIRKKVLADVTTTSLPNNWRWGVLVGVEEVAKLLEGIPVNVYAM PEGTIFHPYEPVLQIEGDYADFGIYETALLGMLSQASGIATAALRIKIAAKFKPVYSFGIRHMHPAIAPMIDRAA FIGGCDGVSGVLGAEMMGEKAVGTMPHALIITVGDQVKAWKYFDEVIEEEVPRIALVDTFYDEKVEAVMAAEALG KKLFAVRLDTPSSRRGNFRKIIEEVRWELKVRGYDWVKIFVSGGLDEEKIKEIVDVVDAFGVGGAIASAKPVDFA LDIVEVEGKPIAKRGKLSGRKQVYRCENGHYHVVPANKKLERCPVCNAKVEPLLKPIIENGEIVVEFPKAREIRE YVLEQAKKFNLEI Pyrococcus furiosus NYSGXRC-6261h SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble EC3078 GENBANK AAG20598.1 MRITGPYQSFARYETALLGFLSHASGMATAALAARRAAPDSHLLSFGARHVHPSIAAVVERAALIGGFDGFSHVAA GDVLDREPGGTMPHALVICFGRGNQEAAWRAFTDGVGDDVPRIALCDTYSDEKDEVLRAVDELGDDLDAVRLDTT SSRRGDFRHIAREVQWALDAGGNSDVSVFVSGGLTPTDLRGLRDVVDGFGVGGFVSNATPVDFGLDIVEVAGEPA AKRGKLSGTKAVYRTPDGGHHVALASQPAPADATALLEPLLVDGTVSMAFDIDDAAARARQDARAVSFRQ Halobacterium sp. NRC-1 NYSGXRC-6261i SGX Pharmaceuticals 2004-07-12 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1904 GENBANK NP_394603.1 MNVFNTASDEDIKKGLASDVYFERTISAIGDKCNDLRVAMEATVSGPLDTWINFTGLDEVLKLLEGLDVDLYAIPE GTILFPRDANGLPVPFIRVEGRYCDFGMYETAILGFICQASGISTKASKVRLAAGDSPFFSFGIRRMHPAISPMI DRSAYIGGADGVSGILGAKLIDQDPVGTMPHALSIMLGDEEAWKLTLENTKNGQKSVLLIDTYMDEKFAAIKIAE MFDKVDYIRLDTPSSRRGNFEALIREVRWELALRGRSDIKIMVSGGLDENTVKKLREAGAEAFGVGTSISSAKPF DFAMDIVEVNGKPETKRGKMSGRKNVLRCTSCHRIEVVPANVQEKTCICGGSMQNLLVKYLSHGKRTSEYPRPKE IRSRSMKELEYFKDIS Thermoplasma acidophilum NYSGXRC-6261j SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC3078 GENBANK NP_213718.1 MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFKFGDEEIKYLKSLGIFK DDFLDYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLLETLVINTIQFETMIASKAVRSYLVAKGKKLV DFGFRRAHGLEAGILAARASYIAGFDGTSNVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLI DTYDTIEAAKKVVDLAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPID AFGVGTKFITSADAPYFDIAYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYDETAKWESKREGEPLVE LVMKNGKLIKELPSLKEIREVVMSELEKLPENYKDITKHYEYEVKILDWE Aquifex aeolicus NYSGXRC-6261k SGX Pharmaceuticals 2004-07-12 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1905 GENBANK NP_269698.1 MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEEL GYPENFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDE PLLEFGTRRAQELDAAIWGTRAAMIGGADATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVF LVDTYDTLKVGVPTAIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKM QKAKIDVWGVGTKLITAYDQPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDY ITFTDINVNELTEIEMFHPTYTYIKKTVKEFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVL NPQDYPVDLARDVWQNKMALIDNIRKDAYGKSE Streptococcus pyogenes NYSGXRC-6261l SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC3078 GENBANK NP_391053.1 VLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRRLPFENGYAVFAGLEKAIEYLENFKFTDSDLSY LQDELGYHEDFIEYLRGLSFTGSLYSMKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKG VIGDEVALEFGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTAFKKYAETH KDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKARKMLDEAGFTDAKVIASSDLDEHTI MNLKAQGARIDVWGVGTKLITAYDQPALGAVYKLVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHS EGDYIALYDEQVNDQKRLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEEY KRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE Bacillus subtilis NYSGXRC-6261m SGX Pharmaceuticals 2004-08-23 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1950 GENBANK ZP_01067918.1 LMTSKTSLALLCDFYEFTMSQGYFKNNKKDQICYFDIFFRKIPDSGSFAIFAGLEDILDFVENLSFDAEDIEFLRK QGIFDTEFLDFLANFKFKGEIYAMREGEVIFPNEPLLCIKATTIEAQLLETFLLLSLNHQSLIATKTNRIVRAAK DSKILEFGSRRAQGSEAALKGARAAFIGGCIGSACTLAGKIYNIPINGTMAHSWVQMFENELEAFKAYVKIYPKN PVFLIDTYDCLNSGLKNAIKVFKEFGIQEGGVRIDSGNLLELSLKIRQELDQAGLQKCKIIVSNALDEWSIKKLK EQNAPIDIFGVGERLITASSDPIFSCVYKLAALEDQGIKPKIKISENNEKSTLPHFKKLFRVYDKNTQKILFDEL YVFDENPNQDENLERKELLELVYKEKRLLKKSSLNTIQDYTKEQISKLDESFLDLDRFVKFEVKLSPKLQNITED LLKTRF Campylobacter jejuni NYSGXRC-6261n SGX Pharmaceuticals 2004-01-20 active Selected EC3078 MAIALSTLVEEADRYLDAARIQDYCPNGLQVEGRPQVRRIVSGVTASQALLDAAVEADADVVLVHHGYFWKGENPC VVGMKQRRLKTLLNNDISLLAYHLPLDLHPEVGNNVQLARQLGFEVEGPLEPGNPRSIVLLGSLAEPMQPADFAR HVRDALGREPLLVDAGQPIRRIAWCTGGAQGYIDQAIAAGVDAYLTGEVSEQTVHSARENGISFIAAGHHATERY GVQALGDYLGKRFAIEHLFIDCPNPA Pseudomonas aeruginosa NYSGXRC-6261o SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC3078 GENBANK NP_143697.1 VRKMKRFYIASEEEIKTGKTTDIYFLRTRKILETKNIRKKVLADVTTTSLPENWKWGVLVGVEEVAKLLEGIPVNV YAMPEGTIFHPYEPVLQIEGDYADFGIYETALLGMLSQASGIATAALRIKIAAKFKPVYSFGIRHMHPAIAPMID RAAFIGGCDGVSGVLGAEMMGEKAVGTMPHALIITVGDQVKAWKYFDEVIEKEVPRIALVDTFYDEKIEAVMAAE ALGKKLSAVRLDTPSSRRGNFRRIIEEVKWELKIRGYDWVKILISGGLDEEKIKEIVDVADAFGVGSAIASAKPI DFALDIVEVEGKPIAKRGKLSGRKQVYRCENGHYHVVPADKKLERCPVCNAKVEPLLKPIIENGEIVVEFPKARD IREYVLEQAKKFNLEI Pyrococcus horikoshii NYSGXRC-6261p SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1951 GENBANK NP_341896.1 MEFYIADFKQIKEGKVTDIYFERTLKTLEYLGIKDAKVRMEVHSYGLPKGYEWALFTGLEEVLHLLEGVPVNVYAM PEGTLFKEIEPVMIIEGNYLDFGIYETAFLGILRHYSSISTKAARLKFLAMDKTLFFFGLRSLHPALAPMADRAA YIGGMDGVSGAMSKEYLGVDPSGTMPHALMLIVGDNVKAWKAFDEAMGSEVPRITLVDTFEDERTEALKAATLLG KKLYGIRLDTPSSRRGNFRKIIQEVKWTLKIHGYDHVKIFASGGIDEDDIINLRDIVDGFGIGTSIAFPPSVDFS ADIVEKFVDGKWVPFTKRGKWPGAKQVYRCGKLNDVITLMDQEHPSSDCKPLLQKYMENGKIIKPLPSPKEIREY VIKQLTELQSS Sulfolobus solfataricus NYSGXRC-6261q SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC3078 GENBANK NP_242358.1 MQTYFKLIFLLSASLLCLGLASPDDSNKGEMKRAAIIIDDFGGDVKGVDDFLTGEIPVTVAVMPFLEHSTKQAEIA QAAGLEVIVHMPLEPKKGKISWLGPSGITSNLSVGEVKSRVRKAFDDIPYAVGLNNHMGSKIVENEKIMRAILEV VKEKNAFIIDSGTSPHSLIPQLAEELEVPYATRSIFLDNTHSSRKEVIKNMRKLAKKAKQGSEPIGIGHVGVRGD ETYAGIRSMLDEFQAESIQLVPVSQLLPSPIEEDHNKFWQQPFQAKE Bacillus halodurans NYSGXRC-6261r SGX Pharmaceuticals 2004-08-23 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1952 GENBANK NP_464617.1 MTNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERIIHYMQNLRFTETDIAYL HDELGFDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEASLAEAQLIETALLNIVNFQTLIATKAARIRSV IDDETFAEFGTRRAQEMDAAIWGTRAAYIGGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHF DSIFLVDTYDTLKSGVPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTIL SLKAQKAKIDSWGVGTKLITAYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTPGKKKVYRIITNEDGLK AEGDYIALADESLENVDKLTMFHPVHTYIMKTVENFTARELLVPIFQNGELVYDMPSLDEIKAYKEENLALLWDE YKRTVRPEQYPVDLSVKCWKNKMRNIEKVRKSVQLHSPVELDMPF Listeria monocytogenes NYSGXRC-6261s SGX Pharmaceuticals 2004-09-15 active Selected Cloned Expressed EC3078 GENBANK NP_486522.1 MTTIPIWDVQQTPELNISAADYSLLTDLYQLTMAACYTGEGVEQRRASFELFVRRSPEGFGYLIAMGLAQALEYLE KLRFSPEQIAALQATGIFAHAGEGFWSLLAEGRFTGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLNTLN YQTLVATRAARLRDIAGEQATLLEFGTRRAFSPQASLWAARAALAGGLDATSNVLAALQLGQQPSGTMAHALVMA LSAMEGSEEQAFSAFHRYFPGAPLLIDTYDTIAAAQHLAEKVNTGKMELSGVRLDSGDLVSLSKQVRSLLPDVSI FASGDLDEWEIAKLQAAGAEIDGYGLGTKLVTGSPVNGVYKLVEIDDIPVMKKSSGKTTYPGRKQIFRSFGDGQV QADRLGLITDTPLITEKPLLELVVKEGQRLQPRETLSAIRQRTAASVASLPEQTRRLDNPVPVPIQISTALQDLT EVTLQRLN Nostoc sp. NYSGXRC-6261t SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC3078 VGNMKMFNIASEDDIKKGLASDVYFERSISTLTETCKDHRVAMEATVSGPLDTWINFSGLDEVLKLLEGIDVDVFA IPEGTILYPRDSNGIPVPFIRIEGNYCDFGMYETSILGMICQASGISTKSSKVRIAAGDCPFFSFGIRRMHPAVS PMIDRSAFIGGADGVSGILGAKLIGEEPIGTMPHALSIILGDDEAWRLTLKNTKNGQKSVILIDTYMDEKFAAIK VAEEFEHVDYIRLDTPSSRRGNFEALVREVKWELALRGRSDIKIMVSGGLDENTVAKLREAGAQAFGVGTSISSA KPFDFALDIVSIDDKPKTKRGKLSGKKSVLRCEKCRKVEVVPYGVESKPCSCGGVMHNIIVKYMEHGKLLSQYPE PKEIRKRTLSELEYFRSSN Thermoplasma volcanium NYSGXRC-6261u SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble Purified EC3078 ICEDB: T1953 GENBANK NP_720907.1 MYKDDSLTLHTDLYQINMMQVYFNQGIHNKRAVFEVFFRKEPFANGYAVFAGLERMIAYLQGLSFSETDIAYLEEL GYPADFVAYLKEFKLELSVKSAKEGDLVFANEPIVQIEGPLAQCQLVETAILNIVNFQTLIATKAARIRSVIEDE PLLEFGTRRAQEMDAAIWGTRAAVIGGANATSNVRAGKLFGIPVSGTHAHALVQAYGNDYDAFMAYAGTHKDCVF LVDTYDTLRLGVPAAIRVASELGDKINFLGVRIDSGDMAYLSKKVRKLLDEAGYPHAKIYASNDLDENTILNLKM QKAKIDIWGVGTKLITAYDQPALGAVYKIVSIEDDNGVMQDTIKLSNNAEKVSTPGKKQVWRITSRAKGKSEGDY ITFTDTDVNSLDEIDMFHPTYTYINKKVRDFDAVPLLVDIFDQGKLVYTQPSLSDIQDYARREFDKLWDEYKRVL NPQDYPVDLACDVWQNKVNLIDRIRKEAYEKGDVK Streptococcus mutans NYSGXRC-6262a SGX Pharmaceuticals 2004-08-12 active Selected Cloned Expressed Soluble EC2472 GENBANK NP_217263.1 VTERPRDCRPVVRRARTSDVPAIKQLVDTYAGKILLEKNLVTLYEAVQEFWVAEHPDLYGKVVGCGALHVLWSDLG EIRTVAVDPAMTGHGIGHAIVDRLLQVARDLQLQRVFVLTFETEFFARHGFTEIEGTPVTAEVFDEMCRSYDIGV AEFLDLSYVKPNILGNSRMLLVL Mycobacterium tuberculosis NYSGXRC-6262b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC2472 GENBANK NP_354724.1 LAIEIKLETPRQEAVLRLIDLSNAYMASLYPAESNHLVDIGALEKDNVSFFVARHDGRVVGCGALVEAGDGTAEVK RMFVDPEARGLRIGKLIMDTLVARGTELGLSAIRLETGISQPEAIGLYRKEGFVEIEAFAPYKPDPLSLFMERAL Agrobacterium tumefaciens NYSGXRC-6262c SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed EC2472 GENBANK NP_420802.1 MPKPQLRIIAGDFEDPRIIALLAHHFATMRSTGPEESCHVMPLGTMRQADLDFFAAWDGDALAGFGAVKQLGDGHG EIKSMHTAAAYRGRGVGQAVLDHLSTHARALGLQRLSLETGAGDFFVPARAMYARNGFQTCDPFGDYKPDPNSVF MTRML Caulobacter crescentus NYSGXRC-6262d SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2472 GENBANK NP_709945.1 MNNIAPQSPVMRRLTLQDNPAIASVIRQVYAEYGLTADKGYTVADPNLDELYQVYSQPGHAYWVVEYNGEVVGGGG IAPLTGSEADICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHIDYAL GCTGHVDCEVRMLREL Shigella flexneri NYSGXRC-6262e SGX Pharmaceuticals 2004-09-15 active Selected Cloned EC2472 GENBANK NP_487170.1 MHIEAYTPHHLEAVVRLSLRAWTPVFDSLQSVMNADVYQAFYPNQWQVSQQKSVEDVCAAEDTNVWVAIDEGSTVG FVAMKLHSEDSMGEIYMVAVDPDFQGHGIGSALIEFALDQMKDAGMSIAMVETAGDPGHAPARHTYEKAGFELFP VARYFKAL Nostoc sp. NYSGXRC-6262f SGX Pharmaceuticals 2004-01-20 active Selected EC2472 MSQLPAWPRITRESTAMYHLRVPQTEEELERYYQFRWEMLRKPLHQPKGSERDGWDALAHHQMVVDEEGNLVAVGR LYINADNEASIRFMAVHPSVQDKGLGTLMAMTLESVARQEGVKRVTCSAREDAVEFFAKLGFVNQGEITTPTTTP IRHFLMIKPVASLDDILHRGDWCGQLQQAWYEHIPLSEKMGVRIQQYTGQKFITTMPETGNQNPHHTVFAGSLFS LATLTGWGLIWLMLRERHLGGTIILADAHIRYSKPISGKPNAVADLGSLSGDLDRLARGKKARVQLQVELLGGET AGAIFEGIYIVLPAKPFGPYEEGGNEEE Salmonella typhimurium NYSGXRC-6262g SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC2472 ICEDB: T1954 GENBANK NP_213936.1 VVRGVLKRSKFRKMIRRAKVGDAKYIYELLTEFAKRGILLPRSLNSIYENIRDFWVYEKDGKVVGCVALHVMWEDL AEIRSLAVKEEYQKEGIGRELVIRALEDAWELGIKKVFSLTYVKEFFKKLGFKEIDKSVLPHKVWGECINCVKFP NCDEEAVLVELSEEYIKKLKEGEKISSLLP Aquifex aeolicus NYSGXRC-6262h SGX Pharmaceuticals 2004-06-10 active Selected Cloned EC2472 MMKPIIREAKPQDKPSIEEIARLTWDGEDYLACVFDEWIKDGNFYVLELNGKVIGTVKLTFLPNRVGWMEGLRVHP NYHGRGFGKMLHDFIVEKGMVLANEGKIEALEFSTYFLNKKTIAMAEKDGFWVKARFFVASVRVSDFEAEEPTRI EPRIEDLTLGIIPVGWRFIKRSEEALEWIRRNAEVYEYNGLHFLGPKNGTTFTPLEPGPAVLRVLLPAMAWVAKE KNREEFSLMLPSSVKPVLPVFRRIGVHIWDNAKEPNVFVFRKKLGV Pyrococcus horikoshii NYSGXRC-6262i SGX Pharmaceuticals 2004-01-20 active Selected EC2472 MSQLPGLSRETRESIAMYHLRVPQTEEELERYYQFRWEMLRKPLHQPKGSERDAWDAMAHHQMVVDEQGNLVAVGR LYINADNEASIRFMAVHPDVQDKGLGTLMAMTLESVARQEGVKRVTCSAREDAVEFFAKLGFVNQGEITTPTTTP IRHFLMIKPVATLDDILHRGDWCAQLQQAWYEHIPLSEKMGVRIQQYTGQKFITTMPETGNQNPHHTLFAGSLFS LATLTGWGLIWLMLRERHLGGTIILADAHIRYSKPISGKPHAVADLGALSGDLDRLARGRKARVQMQVEIFGDET PGAVFEGTYIVLPAKPFGPYEEGGNEEE Escherichia coli NYSGXRC-6263a SGX Pharmaceuticals 2004-09-14 active Selected Cloned Expressed EC3462 GENBANK NP_216208.1 MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSRKLFVTNNASRSADEVAAHLCELGFTATGEDVVTSAQS AAHLLAGQLAPGARVLIVGTEALANEVAAVGLRPVRRFEDRPDAVVQGLSMTTGWSDLAEAALAIRAGALWVAAN VDPTLPTERGLLPGNGSMVAALRTATGMDPRVAGKPAPALMTEAVARGDFRAALVVGDRLDTDIEGANAAGLPSL MVLTGVNSAWDAVYAEPVRRPTYIGHDLRSLHQDSKLLAVAPQPGWQIDVGGGAVTVCANGDVDDLEFIDDGLSI VRAVASAVWEARAADLHQRPLRIEAGDERARAALQRWSLMRSDHPVTSVGTQ Mycobacterium tuberculosis NYSGXRC-6263b SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble Purified EC3462 ICEDB: T1955 GENBANK NP_343718.1 MSVLNGYQLIISDVDGVIVREGDPIWENIQALRNIQNNGVKIIFVTNNSGFSRILLSRQLSYLGLKVTPDMIITSG LAAAIYMKEKLNVKSVFAVGEEGLIEELKNHGFLVFSSAESERILPDAVVMGLDRLSTYDKLSLAMRCISKGSKF IVTNMDRLWPAKDGLKLGAGALASSIIYALRRDPDFIAGKPNTWIVEIAMRISNVKKLDKILVIGDQIETDIQMG YNIGADTALVLTGISNVDDVDRSNVKPKYVVNTLLDLL Sulfolobus solfataricus NYSGXRC-6263c SGX Pharmaceuticals 2004-06-10 active Selected EC3462 MSDAPTSPRFSAATSTRLLDHAQLEALCADYDGFLLDLWGVVMDGTEAFPGALAWLARRHAEGRPVWFLSNSSSSV AEMSAGLERLGIRRDWFAGITTSGQLTIDALLQTAEYRRGGIYLAGVGLAQQSWPAEIRERFVEDIAQAALIVGV GSFPQDELEQRFAPLRGATDLPFLCANPDRVVVSGGRTVYGAGMLAELFSEEGGQVSWYGKPDPAAFRIAQRQLE ARGARHILFVGDSLVTDVPGALAARIDTLWLGATGIHREALGAEFNGALDEERVRSLLHGYPIRPHFAAPGLV Pseudomonas aeruginosa NYSGXRC-6263d SGX Pharmaceuticals 2004-01-20 active Selected EC3462 MVAIIFDMDGVLYRGNRAIPGVRELIEFLKERGIPFAFLTNNSTKTPEMYREKLLKMGIDVSSSIIITSGLATRLY MSKHLDPGKIFVIGGEGLVKEMQALGWGIVTLDEARQGSWKEVKHVVVGLDPDLTYEKLKYATLAIRNGATFIGT NPDATLPGEEGIYPGAGSIIAALKVATNVEPIIIGKPNEPMYEVVREMFPGEELWMVGDRLDTDIAFAKKFGMKA IMVLTGVSSLEDIKKSEYKPDLVLPSVYELIDYLKTL Pyrococcus horikoshii NYSGXRC-6263e SGX Pharmaceuticals 2004-08-23 active Selected Cloned Expressed Soluble Purified EC3462 ICEDB: T1956 GENBANK NP_248441.1 MIKGILFDLDDTLYNSSEFVEIARREAVKSMIDAGLNIDFEEAMNILNKIIKDKGSNYGKHFDDLVKAVLGKYDPK IITTGIITYHNVKVALLRPYPHTIKTLMELKAMGLKLGVITDGLTIKQWEKLIRLGIHPFFDDVITSEEFGLGKP HLEFFKYGLKRMGLKAEETVYVGDRVDKDIKPAKELGMITVRILKGKYKDMEDDEYSDYTINSLQELVDIVKNLK KD Methanococcus jannaschii NYSGXRC-6263f SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC3462 GENBANK NP_279720.1 MPCPSHRSGAGAALFAPPPRAAGVSDEAADGVLFDLDGTIYVGDALVPGAAAAVDGLRAAGVGVGFLSNKAIERRD AFVSKLDGLGVPADESAILNAASIAASYLARAHPGESVFVVGEPPLFEELAAHGVATTTDPGRADVLLVSMDHDF DYDTLTDAFNAVDEGTPFLATNPDRTCPVAGGEVPDCASMVGAIEGATGRSLDRVLGKPSPVAVEAATDLLGVPL ARCVMVGDRIETDIEMGNRAGMTTVLVLSGVTDDAALAASDVEPDHVIDSVSDLDTVLPALP Halobacterium sp. NRC-1 NYSGXRC-6263g SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC3462 ICEDB: T1957 GENBANK NP_069210.1 MMPDKKGYIIDIDGVIGKSVTPIPEGVEGVKKLKELGKKIIFVSNNSTRSRRILLERLRSFGLEVGEDEILVATYA TARFIAREKPNAKVFTTGEEGLIEELRLAGLEIVDYDEAEYLVVGSNRKINFELMTKALRACLRGIRYIATNPDR IFPAEDGPIPGTGMIIGALYWMTGREPDVVVGKPSEVIMREALDILGLDAKDVAVVGDQIDVDVAAGKAIGAETV LVLTGVTTRENLDQMIERHGLKPDYVFNSLKDMVEALEG Archaeoglobus fulgidus NYSGXRC-6263h SGX Pharmaceuticals 2004-01-20 active Selected EC3462 MEMRIVFDMDGVLYRGNTPIEGAREVIEFLKEKGIKFAFLTNNSTKTPEMYRERLLKMGIDVPADSIITSGLATRI YMKKHFEPGKIFVIGGRGLVEEMEKLGWGIVSVEEAREGIWKEVKYVVVGLDPELTYEKLKYGTLAIRNGAEFIG TNPDRTYPGEEGIYPGAGSIIAALEAATDKKPLIIGKPNEPMYEVLREKLGEGEVWMVGDRLDTDILFAKKFGMK AIMVLTGVHSLSDIEKSDIKPDLVLPSIKELLEYLKILHDEDKEGTK Pyrococcus furiosus NYSGXRC-6263i SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC3462 GENBANK NP_353708.1 MAHRILTLGEITDGFDVVLSDVWGVLHNGVSAFPDAAVALHEARKAGKTVVLITNSPRPAPGVIAQLRVLGVPDEA YDRIITSGDVTRGLIAEGPKKVFLLGPERDMPLLEGLDVERVGEAEAQSVVCTGFFDDETETPEDYTEMLKGFIA RKVPMICANPDLVVERGERIIPCAGAMAAYYEQLGGEVRIAGKPHAPIYEACLAAAKDVRGAFAKDRVLAIGDGM PTDVKGAIASGLNLLYISGGIHAAEYTLNGQTDEALLNAYLKGQGAAPGWWMPRLA Agrobacterium tumefaciens NYSGXRC-6263j SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble EC3462 MAKKLSSPKEYKEFIDKFDVFLFDCDGVLWSGSKPIPGVTDTMKLLRSLGKQIIFVSNNSTKSRETYMNKINEHGI AAKLEEIYPSAYSSATYVKKVLKLPADKKVFVLGEAGIEDELDRVGVAHIGGTDPSLRRALASEDVEKIGPDPSV GAVLCGMDMHVTYLKYCMAFQYLQDPNCAFLLTNQDSTFPTNGKFLPGSGAISYPLIFSTGRQPKILGKPYDEMM EAIIANVNFDRKKACFVGDRLNTDIQFAKNSNLGGSLLVLTGVSKEEEILEKDAPVVPDYYVESLAKLAETA Schizosaccharomyces pombe NYSGXRC-6263k SGX Pharmaceuticals 2004-06-10 active Selected EC3462 MPNMSTHFHHQPVEAFIIDLDGTMVDTIDDLAIAFNTALNQLGLAPVATAFVERMINKGPEHLVRAALGDAGTDMA LYERCLQLYRKAYGEINGKYARVYPGVGESLAELRALGMKLACLTNKPGSFARALLKEKQLDGFFSVVFGGDAFP CQKPDPLPVIRTCEALGTAPSRTLMVGDSNNDALAAKAAGCRVVLVKYGYHHGESRSRTHVDGVIDGLHQLRPFC RLADQDA Ralstonia solanacearum NYSGXRC-6263l SGX Pharmaceuticals 2004-07-20 active Selected Cloned Expressed Soluble Purified EC3462 ICEDB: T1906 GENBANK NP_285894.1 VAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMD WSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAVAANVGT KVLVRTGKPITPEAENAADWVLNSLADLPQAIKKQQKPAQ Shigella flexneri NYSGXRC-6264a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3408 VTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPYSDIDLLVTVAVKLDETTRRALLNDLMEASAFPGES ETLRAIEVTLVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFD PVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKGVAADWAIKRLPAQYQPVLLEAKQA YLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK Pseudomonas aeruginosa NYSGXRC-6264b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC3408 GENBANK NP_579710.1 MPREKVVRVWDEREVVYSPKRWRILWEKREKALKIMELLKDFDPHVYGSVARGDVRRDSDIDIVIPYRVPSYLIEL ALGDLIQRRRIVMATPWHLIKGHIEIDEETTVTFFLVDPTDRELEFYKWGGMLDLWGVKTKQRVPGVNKKLILII PTDKGHIEREVVGREAEVAKILGVSVDIVEERVKVLTRRDRIGRTGIYLDEEVPDWKSFEEFLKELADRDPNIRR RVRESL Pyrococcus furiosus NYSGXRC-6264c SGX Pharmaceuticals 2004-07-22 active Selected Cloned Expressed Soluble Purified EC3408 ICEDB: T1958 GENBANK NP_456247.1 MTLSIPPSIQCQTEAACRLITRVTGDTLRAIHLYGSAVAGDLKPNSDIDLLVTICQPLTETQRATLMQELLALSSP PGASAEKRALEVTVVLYSQLVPWCFPPSREMQFGEWLREDIYQGIYEPAQQDWDMVLLITQILETSIPLKGERAE RLFTPAPAAQLLKALRYPLDLWQSTADVQGDEYHIVLTLARIWYTLSTGRFTSKDAAADWLLPQLPEEYAATLRA AQREYLGLEQQDWHILLPAVVRFVDFAKAYIPTQFT Salmonella typhi NYSGXRC-6265a SGX Pharmaceuticals 2004-06-10 active Selected EC3639 MYRDRVRLPSLLDKVMSAAEAADLIQDGMTVGMSGFTRAGEAKAVPQALAMRAKERPLRISLMTGASLGNDLDKQL TEAGVLARRMPFQVDSTLRKAINAGEVMFIDQHLSETVEQLRNHQLKLPDIAVIEAAAITEQGHIVPTTSVGNSA SFAIFAKQVIVEINLAHSTNLEGLHDIYIPTYRPTRTPIPLTRVDDRIGSTAIPIPPEKIVAIVINDQPDSPSTV LPPDGETQAIANHLIDFFKREVDAGRMSNSLGPLQAGIGSIANAVMCGLIESPFENLTMYSEVLQDSTFDLIDAG KLRFASGSSITLSPRRNADVFGNLERYKDKLVLRPQEISNHPEVVRRLGIIGINTALEFDIYGNVNSTHVGGTKM MNGIGGSGDFARNAHLAIFVTKSIAKGGNISSVVPMVSHVDHTEHDVDILVTEQGLADLRGLAPRERARVIIENC VHPSYQAPLLDYFEAACAKGGHTPHLLREALAWHLNLEERGHMLAG Pseudomonas aeruginosa NYSGXRC-6265b SGX Pharmaceuticals 2004-08-24 active Selected EC3639 GENBANK NP_465696.1 LSKVIKASEAAKLLKDGDTVAFSGFGLACVNEEMAIAVEKRFLEEGAPRNLTVMHASALGDRREKGMSHWGHEGLI KRWIGGIAIASPKMAKLIEEDKCEAYNLPQGVITQLYREIAAKRPGVITKIGMGTFVDPRIEGAKMSASSKDNLV ELLTIHNEEWLFYPSFPIQVALIRGTVADEFGNLTLEKEGLHMEVLPIAQAVRNSGGIVIAQVESVAKKGSLNPK DVRVPGILVDHIIISEPENHFQTENTQYNPAFSGHIQVPLGDIEPLPLDDRKVIARRSAAELEPQTILNLGVGIP VNVSTVAAEEGVSDQLILTTEAGSVGGVPAGLADFGHAYNSEAIVDHHSQFDFYDGGGLDLSVLGLAQTDESGNV NVSKFGSRVAGCGGFINISQSAKKLIFAGTFTAGGLKTRVAAGKLEILQEGKAKKFIKQVQQITFSGEYASTTNQ TILYVTERAVFRLENGKMVLTEIAPGIDLEKDILGQMEFEPIIASDLKVMDGGMFSEEWGGLKAIIEKQTREGVS I Listeria monocytogenes NYSGXRC-6265c SGX Pharmaceuticals 2004-06-10 active Selected Cloned Expressed Soluble EC3639 MPSLLSSRIRNAEFAKKIVTDPAKLVPYFKNGDYVGWSGFTGVGYPKMIPNALARHVEENNLQGKLRFKLFVGASG GADTECKWAELNMIERRCPHQVGKPISKGINSGRIQFFDKHLSMFPQDLLYGYYTRNRESNTIDTAIIEATAITE DGGIVPGASVGASPELMQLAEKIIIEVNTAIPSFEGLHDIVEIPNPPHRTPININRVDDRIGKPYIKVDPKKVIG IVEADYGDITCANSPQDETSQAIAGHLVDFFHHEVSVGRLPKNLHPLQSGIGNIANAIIGGLAHSPFKDLEVWTE VLQDTFLPLFDSEKLRFATATSTRFSPQGFEKFYSNYDYYKERILLRPQVISNHPEIIRRLGCIAMNTPVEADIY AHANSTNVLGSRMLNGLGGSADFLRNAKLSIMHTPSVRPSKKDPTGITCIVPMATHVDQTEHDLDILVTEQGLAD LRGLSPTERAREVIDKCAHPDYKPLLREYFDIAENYCLARGAGHEPHILANAFKMQLNLLEKGTMKIDHW Schizosaccharomyces pombe NYSGXRC-6266a SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2134 GENBANK NP_251277.1 MTVLIQGAGIAGLALAREFTKAGIDWLLVERASEIRPIGTGITLASNALTALSSTLDLDRLFRRGMPLAGINVYAH DGSMLMSMPSSLGGNSRGGLALQRHELHAALLEGLDESRIRVGVSIVQILDGLDHERVTLSDGTVHDCSLVVGAD GIRSSVRRYVWPEATLRHSGETCWRLVVPHRLEDAELAGEVWGHGKRLGFIQISPREMYVYATLKVRREEPEDEE GFVTPQRLAAHYADFDGIGASIARLIPSATTLVHNDLEELAGASWCRGRVVLIGDAAHAMTPNLGQGAAMALEDA FLLARLWCLAPRAETLILFQQQREARIEFIRKQSWIVGRLGQWESPWSVWLRNTLVRLVPNASRRRLHQRLFTGV GEMAAQ Pseudomonas aeruginosa NYSGXRC-6266b SGX Pharmaceuticals 2004-09-14 active Selected Cloned Expressed EC2134 GENBANK NP_215776.1 VKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDVRGPALDVLERMGLLAAAQEHKTRIRGASFVD RDGNELFRDTESTPTGGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFDL VIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEARAALAFMDT ELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALVGDAGYCCSPLSGQG TSVALLGAYILAGELKAAGDDYQLGFANYHAEFHGFVERNQWLVSDNIPGGAPIPQEEFERIVHSITIKDY Mycobacterium tuberculosis NYSGXRC-6266c SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed EC2134 GENBANK NP_051608.1 LQAAKEVCLWPLHEREPDTTWSRGPLVLLGDAGHPMRPHMAQGAAMAIEDAAVLVRCLRAYGAAAGAAYDHYQQTR AERVAQVQKVSSENSWMRTPTDPEWVFSYDALLAPLR Deinococcus radiodurans NYSGXRC-6267a SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble EC300 GENBANK NP_217540.1 MKVLAAMSGGVDSSVAAARMVDAGHEVVGVHMALSTAPGTLRTGSRGCCSKEDAADARRVADVLGIPFYVWDFAEK FKEDVINDFVSSYARGETPNPCVRCNQQIKFAALSARAVALGFDTVATGHYARLSGGRLRRAVDRDKDQSYVLAV LTAQQLRHAAFPIGDTPKRQIRAEAARRGLAVANKPDSHDICFIPSGNTKAFLGERIGVRRGVVVDADGVVLASH DGVHGFTIGQRRGLGIAGPGPNGRPRYVTAIDADTATVHVGDVTDLDVQTLTGRAPVFTAGAAPSGPVDCVVQVR AHGETVSAVAELIGDALFVQLHAPLRGVARGQTLVLYRPDPAGDEVLGSATIAGASGLSTGGNPGA Mycobacterium tuberculosis NYSGXRC-6267b SGX Pharmaceuticals 2004-08-18 active Selected Cloned EC300 GENBANK NP_419714.1 VRAAVGLPEGARIVAAMSGGVDSTVTAALLARAGYDVVGVTLQLYDHGAAISRKGACCAGQDILDARMAAERIGIP HYVLDYESRFREQVIEDFADAYLRGETPIPCVRCNQTVKFRDLLDVARDLGAEAMATGHYVQRAMPGNGGNRPEL RRAADPAKDQSYFLFATTREQLDFLRFPLGGMDKPTVRAVAAGLGLSIADKPDSQDICFVPEGKYTTVIDRIRPQ GAEAGDVVHLDGRVLGRHEGVTRYTIGQRRGLNIAVGDPLFVVKINADKRQVIVGPREALLTASLTLKEGSWLGA QDSLEAAAEDGQRVLARVRSTREPVPGRLAMIDGALSVVFDGAEEGVAPGQACVLYDPADPDRVLGGGFIAGTTR QMDLNAA Caulobacter crescentus NYSGXRC-6267c SGX Pharmaceuticals 2004-08-13 active Selected Cloned EC300 LSTNNSDIRVVVGMSGGVDSSVTAHILKEQGYDVIGIFMKNWDDTDEFGVCTATEDYDDVIRVANQIGIPYYAVNF EKEYWDKVFTYFLDEYKLGRTPNPDVMCNKEIKFKAFLEHAESLGADYVATGHYAQVKKVGDEIELLRGVDNNKD QTYFLNQLSQDQLKKVMFPLGAMEKTEVREIAKKAGLATADKKDSTGICFIGERNFKQFLSEYLPAQPGEMRTLD GEVLGKHDGLMYYTIGQRHGLGIGGDGEPWFVVGKDLKENVLFVEQGFHHETLYSDSLIATDISFTTNAEKPKTI ECTAKFRYRQTDTKVTVHLREDGTAEVVFADPVRAITPGQAVVFYDGDVCLGGGTIDTVWKNGQKLDYVG Listeria monocytogenes NYSGXRC-6267d SGX Pharmaceuticals 2004-08-19 active Selected Cloned EC300 GENBANK NP_815733.1 MADNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVAKVADQIGIPYYSVNFE KEYWDRVFEYFLAEYRLGRTPNPDVMCNKEIKFKAFLDYAMQLGADYVATGHYAQVETDENGVVHMLRGIDNNKD QTYFLSQLSQAQLAKTMFPLGGMEKSEVRAIAERAGLATAKKKDSTGVCFIGEKNFKEFLSNYLPAKKGNMVTED GEIKGQHDGLMYYTIGQRQGLGIGGGGKTQEPWFVIGKDLTTNTLYVGQGFHHEKLYATHLEASEVHFTVDTPMP KEFDCTAKFRYRQADIPVHVSLSEDGTKATVTFKEPARAVTPGQAVVFYDGMECLGGGLIDRAYQDEKELQYV Enterococcus faecalis NYSGXRC-6267e SGX Pharmaceuticals 2004-09-15 active Selected Cloned Expressed EC300 GENBANK NP_485402.1 MKKVVVGLSGGVDSSTAAAILHNQGYEVIGLTLWLMKGKGQCCSEGMIDAAYICEQLGIPHEVVDMRDVFQTHIVD YLVTGYGAGITPLPCSQCNKTVKFGPMVQYASEKLGCDRIATGHYARIRYDEATGRYQLLRAVDRNKDQSYFLYD LSQDLLAASLFPLGEMEKADTRRIATEHGLKTADKPESQDLCLVESNGSMRAFLDKYIAPKKGDIVDTAGKVLGQ HDGVHHYTIGQRKGLGIAAPEPLYVVELDAVHNKVVVGDRTKATQEECTVNRVNWVSIAEPSTPIRAAVQIRYRS APEPVTVIPLENSRVRLVFDEPQFSITPGQAAVWYDGNKVLGGGIIEQFSK Nostoc sp. NYSGXRC-6267f SGX Pharmaceuticals 2004-06-10 active Selected EC300 MPDEYLGCDDVGTPRGPTVYMAPKLFNPAGGSFFMLNNVIRELKRFGEETKIINKRIILMFSGGKDSSLALYLLKE AGYNVSALTFFHKWSWPEVLRWGMKFTKKLGVTHYLIDITEGLKREAIGRKGPICIHCKKVMLWNAKWFAVNNGF ELIAKGDNANDKIIGTLLDQCPGDIRICEIPKIGIPIFRPLIKYKAREIEMLTNEAGIKPYRMYEHGRRKQWREG CPLQYIDEDTRITEELMDLAFRVNYKVSKIARERKVRISVRVPSFEIMCWNCDNETLKEVKKVINKETL Pyrococcus horikoshii NYSGXRC-6267g SGX Pharmaceuticals 2004-08-24 active Selected Cloned Expressed Soluble Purified EC300 ICEDB: T1959 GENBANK NP_070385.1 MQSLIGLMRPETGKKLENLNHFIQQFEKVLIAFSGGVDSSTLAAVCSNAGVEVLAVTVLSSVSPRREMEEAKRIAE ELGVRHEFLKIDLMDEDFRRNDENRCYYCKRRVLSALVEEAKKRGIEVVLEGTNASDLSDHRPGYRAVRELDGVN SPWVEFGITKEEIREIARSMGYSFHDKPSMACLASRIPFGIEIDEEKLKMVDEAEEAVIELAGVKQVRVRNYDGV AVVEVAGDELRKLLNCAEKVRDKLKKIGFRAVLIDLEGYRSGKRLFKF Archaeoglobus fulgidus NYSGXRC-6268a SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3940 VKIKFKRLDYQEQCRDQILGVFKGIDLREPENDIQRIANPVFEIGAIKDLLLENIENLRSKQKITQGSVGINQSLN CDILMETGTGKTFCFLECVYALHKNYHLSKFIVLAPSNAIKLGVLKSIEITREFFKSEYSNTHLESYEDVERFIL ASNHKCCVLVMTFSAFNKEKNTINQSCLENTNLFNGAKSYMQALASMRPIVIMDEPHRFLGDKTKKYLEQLNALI TLRFGATFKDDYHNLIYALDSKKAFDCALVKSISVASVGESDEYFLELKEANKKQNEATINYTTLENKIQSVKVK THDNLGALTHISALEDYIVEKITKTEIRFLNGFNLLLDQKEPFSHLLEGEQEVMLKEAIKSHFEREEGLFKKGIK ALCMVFINGVNSYLSENEKPAKLALLFEKLYQQKLEEVLKKPLDENYRAYLERTKDAILKVHGGYFAKSKKESDE VQVIALILKEKEKLLSFDSDLRFIFSQWALQEGWDNPNVMTICKLAPSSSNITKLQQIGRGLRLAVNDKGERITK EHADFDFVNELVVIVPQVEGDFVGAIQQEISEHSLIKQVFSAEELEKSGMVKKGYYGVLFETLEGLGFGEKTDDE NFKLTLNQNEFLKKEPELEKLKDEKYLDFEKLKDFLKDRLIGHFRVRNKNERKTEKIKINKENFKKFETLWAGLN HQARIAYAIDSESLIDEIVKNINSSFNVSSKIVSVTTHKKVETMGNNAKTEIFERKSACVWSLHEFISALSNKVK LSFKSVAKVLENIDENKFNEIKKNEQEGLKRLEELFLEIIYQNIKDKISYQMRETTIKNRKNDAFYDEKGEIREF LDGSLGADKYEIKNSSAQEKCLYENFMQVDSEIEKDTIEESNDTKIIVFGKLPRVKIPIGLNQTYSPDFGYVVEN NDKKVLLVVETKGVDKKSELRPEEKRKISTAKKFFEALKKQGVNIEYKTKLNNDQLSALINEVLNRKD Helicobacter pylori NYSGXRC-6268b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed EC3940 GENBANK NP_243683.1 MDIQIQYSTDWKEEFLKRLEDGGPWSNWEMGKLAYEAANYQVIPEFHGLQAPKHLPQLQPFPHQMEVAQTVIEQMN GKAILADEVGLGKTIEAGLILKEYMIRGLAKKVLILVPASLVSQWAYELSSKFYIPAIPQKKAYVWEQYDVVVAS IDTAKRQPHRDIVLNQHYDLVIIDEAHKLKNPKTKNYAFIKSLKRKYCLLLTATPVQNKLEEIFNLVSLLKPGHL GDLESFEKEYRANKRAPKNEDKLKELVNKVMVRNRREETGIEWTKRIVQTVPITFSEGERAFYHAITKLKQQPDV MTNSFSLLTLQREICSSREAAFMTLKNMITKLEQEGRTSPILESLIEQVGTIEGHAKAEKALELIQQINDKVIIF TEYRATQLYLQWYLKQHGISSVPFRGGFKRGKKDWMRQLFENRAQVLIATEAGGEGINLQFCHHIINYDLPWNPM RIEQRIGRIHRLGQTEDVRIYNFAVKDTIEEQILTLLYEKIQLFERVVGELDDILTKMNVGSIEEHIRDIFVHSD SEGEMKIKLDHLSAIMNDVANEKEEDHATGATASVSDALL Bacillus halodurans NYSGXRC-6268c SGX Pharmaceuticals 2004-01-22 active Selected EC3940 MMMNILLEELPHQEQALAAILASFTGIDHAQADHNHYANPLIKGRYDDKANIDVKMETGTGKTYVYTRLMYELHQK YGLFKFVLVVPTPAIKEGARNFITSDYARQHFSQFYENTRMEFCTINAGDFKVKSGRKNFPAQLLSFTDASRRDS HTIQVLLINAQMLNSASMTRNDYDQRYWAGRRLLKGCKRDRWSLLMNRIVLCEITNFIERFRPFSRKSSALALPS RILSKVRVKINVYVKITIAGNRSLISTRWTVLTMVWKVLIFITRISPKNRPTIVISLTASRQRNSSDGGAKLPRL AWAKISPMSMQDLKAVSNMPAVKCCRTIWSWRQGWRWCQEPLARATRNLFRTLSISILTLSRQISYAAMSQKIMP RVLRPAFSLLTVLKAIVMTKVGNSLSVYKRNRNLTIISARPCREKWSICRFCRPRSPACTRITKTSTLVTLAKTA EAAMRRSRLRMIFKIKRSCSVFQTITATGKRAAFCFQNGRFAKAGITRMFLSLLNYVLPVASRAKFRKWGAACGY RMKTAIAFIRKSGRPDCRFLVMMKKRLPVCWLMRLIATAKFSLTSRSWMRRSHSSSPSDKKSILRLRSFVCWKIW MIKNSTGVMSLNPASRLTGKPKVALRGYWSSTLSRRRGCERIAFVTISPPPDCESGYAKRIGNNLAVSGSSFPAV ICCNSSVAALLWNRLPPRCCAIRRCIYARSQARCNNGWYRMKIMAVLKWRSGKANPPANLWRANMAIFLSNWRYA PVCRLTSCTRCWRCCVMFCTEIHAIARSRWTIPAHYRRGLMRILRSATIICLSIFRLQRRYLILRHGSSERRLAL KLWGKMWMRMRTIPVLFIKYRRCVMTASIQNCRYNTIIRNRFLCLANCLSGPFRSPNIRGALLRRILCTVLSVRT PTVFIYWLKLKQKICAAIRLFLMRNVNSSICCVGKISMSSLRKRPARRRYFLPSMALGGRQT Salmonella typhi NYSGXRC-6269a SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC2237 MALAHTLGFPRIGRDRELKKAQEAFWKGELDEAGLRAVGRQLRAAHWQVQKDAGIQLLPVGDFAWYDQVLTHSLTF GVIPERFRAHGEAGPTLHTLFGMARGVSDDSCCGGAHAQEMTKWFDTNYHYLVPEFSADQQFQLSWEQLFEEVDE ARALGHQVKPVLIGPLTYLWLGKAKGAEFDRLDLLDRLLPLYGQIFRRLAGQGVEWVQIDEPILVLDLPQAWKNA FERAYNLLQSEPLKKLVATYFGGLEDNLGLAANLPVDGLHIDLVRAPEQYPSILDRLPAYKVVSLGLVNGRNVWR CDLEKALEVVRHARERLGERLWVAPSCSLLHSPVDLEREDGLDAELKSWLAFAVQKCREVAVLARAATEPEAAEV LAALEESRAVQASRASSPRIHKPAVQARLAAIKASDAQRRSPFAERIARQRAGLDLPAFPTTTIGSFPQTSSIRL ARQSFKQGKLSEAEYIEAMHSEIRHAVQIQEQLGLDVLVHGEAERNDMVEYFAEQLDGYVFTRFGWVQSYGSRCV KPAVIYGDLSRPRAMTVEWIRYAQSLTDKVMKGMLTGPVTMLMWSFPREDVSREVQARQLALAIRDEVVDLEAAG IRIVQIDEAAFREGLPLRRNAWPHYLEWATEAFRLCASGVRDETQIHTHMCYSEFNDVIESIAAMDADVITIETS RSDMELLEAFEQFDYPNEIGPGVYDIHSPRVPSREEIVALLRKAARRIPAERLWVNPDCGLKTRAWPETEAALVN MVAAARELRGDLARG Pseudomonas aeruginosa NYSGXRC-6269b SGX Pharmaceuticals 2004-07-19 active Selected EC2237 MTTTHILGYPRIGEKRELKFALEKYWRGEIDQAALKQVGSQIRQKNWALQKEAGLDFVTAGDFAWYDHVLTTTLLL GHVPKRHSHGFPDLDTLFRVGRGQSQNACGCGTGSAASDMTKWFNTNYHYIVPEFSSNDTFNVSWPQLFEEVNEA LQAGHDVKPVLLGPISYLYLGKEVEEGFDRLTLLPRLLTAYQAILSKLAKQGVQWVQIDEPILALELEPRWQEAF KLAYQVIRGDVKLLLTTYFDSVLDTLDKIVELPVDGLHVDISAAPAQLETIVNRLPSDWVLSAGVINGRNVWRAD LSAILARLQPVKTLLGERLWVASSCSLLHSPVDLDLEGDLSAETRSWFAFAKQKVTEVALLGRALEGDAAAILAC DTYSQPIVARKSSHIVNKASVQTRINNITAALAERSAPYIERAHHQAEVLGLPFLPTTTIGSFPQTGEIRTERSA YRQGKLSEQEYVQALKGHIADAVKRQEALGLDVLVHGEAERNDMVEYFAENLAGFQTTQFGWVQSYGSRCVKPAI VVADIEREKPITVEWSTYAQSLTSKQMKGMLTGPVTILCWTFPREDISRQEIAQQLALALRDEVADLQDAGINII QIDEPAIREGLPLKKRDHQTYLDWAVQAFKISAGSARPETQIHTHMCYSEFNEIIESVAALDADVITIETSRSNM ELLKAFEEFNYPNEIGPGVYDIHSPNIPAQAWIEDLLRKAAEKIPAQRLWVNPDCGLKTRNWPEVEAALTNMVNA AKALRAEWQA Vibrio cholerae NYSGXRC-6269c SGX Pharmaceuticals 2004-07-27 active Selected Cloned Expressed Soluble Purified EC2237 ICEDB: T1960 GENBANK NP_241304.1 MLTSNLGYPRIGENREWKKALESFWANDTTEEQLLATMKELRLNHLRVQQEQEVDLIPVGDFTLYDHVLDMAVMFG IIPKRFLQQGDTPTLSTYFAMARGSKNAQACEMTKWYNTNYHYIVPELHDAAPRLTKNAPLEAYLEAKNELGIDG KPVILGPYSFVKLAKGYEEDKLQETIQSLLPLYIQVIQELVDAGARSIQVDEPSLVTSISAREMALVTRIYEQIN EAIADAPLFLQTYFDAVTFYEEVVSLPVKGIGLDFVHGGAKNLEALRTFGFPEDKVLAAGIIDGRNIWISNLRER HELVHQLEQHVAKDRLVLQPSCSLLHVPVTTKREEKLDPTLLGVLAFANEKLTELHTLKQLAAGNEAEVKEALEA NDDALAALEKSGWRSGAATSHNLENKKRPQSFNERRPLQEEKWQLPLLPTTTIGSFPQTKDVRRTRSLWRKGELS TVEYERTMKSYIEKWINIQEELGLDVLVHGEFERNDMVEFFGEKLDGFAFTANGWVQSYGSRCVKPPIIYGNVSF TEPMTVAETVYAQSLTDKPVKGMLTGPVTILNWSFVRDDLPLTVIAHQIAEALTHEVTALEEAGIEMIQIDEPAI REGLPLKAEDQQEYLDWAVSAFRASCAHVKATTQIHTHMCYSEFHEMIEAIDDLDADVISIETSRSHGEMISAFE KTTYEKGIGLGVYDIHSPRVPSEEEMLNVIRRALTVLPASLFWVNPDCGLKTRAEKETVAALKNMVAAARAAREE LKTKA Bacillus halodurans NYSGXRC-6269d SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble Purified EC2237 ICEDB: T1961 GENBANK NP_356800.1 MKTLLPTSTAGSLPKPSWLAQPEKLWSPWKLQDEELIEGKRDALRLSLNDQQQAGIDIVSDGEQTRQHFVTTFIEH LSGVDFEKRETVRIRNRYDASVPTVVGAVSREKPVFVEDAKFLRQQTRQPIKWALPGPMTMIDTLYDSHYKSREK LAWEFAKILNQEARELEAAGVDIIQFDEPAFNVFFDEVNDWGVATLEKAIEGLKCETAVHICYGYGIKANTDWKK TLGSEWRQYEEAFPKLQKSNIDLISLECHNSRVPMDLIELIRGKKVMVGAIDVATSAIETPEEVADTLRKALRFV DADKLYPCTNCGMAPLSRQVARSKLNALGAGAEIIRRELSV Agrobacterium tumefaciens NYSGXRC-6270a SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3941 LGCVFTNFRLRRSQTPKAKTPMIFEKQDYQQECIYNIITLLDGFDFKRHDALNLKDCLNQFHAACEIPVKNVSGKL NVDVLMETGTGKTFTYLNLIFALHKAYGQNKFIIFVPRKAILESVKQNIRLTKDYFYLEFKRHLKTYTYEGVKSP SNIINHYIKNQDELSVLLLTNSAIDKEGNILNKNSENLFNTKSIFENIADLKPISIIDEPHLLKGEAFGKYFGKI GALYFRFGATFAKEKEHALSNVAFCLDSISAFRNYLVKQIRIHSVMQDAQSPFLLNADSKSAKIAFYKAGILKQI TLSKGEDLGKINASFNGVSLVKTAKDKAYLSNGATLEKASYKLAQDEISALLEKAIDLHFEKEAFLFDQNIKALS LFFIPKIEDFRQIDNKGTPFIKTEFERLYKLKRASILARENLSPSYKEYLKRDFDESGNLRVHQGYFSGDSVALN KGKKESKKEDIEANDIKMILSEKEKLLSFQTPLRFIFSVWALQEGWDNPNIFTLIKLANSTSETSRHQQVGRGLR IAINQEGKRVTHGFLKGNDNAFYKINYLDMLVSGEEVGFIEGLQKEIEASSFIGGGNALDREDLAKLGLNEREIN KLFVELENSNALEFDETNNAYKIIAPICETMQNNEERIKDFLSDEEYHAVLSAFKMAENPTNKRDQIINANQPQE KVKIRQNLAKEFKELWQTINAQSQLSYQNIQKTKLIESIAKAFNESHVSAEVIKFESKRYDPQTNRIITEQSSTL KIRDYANALQKEINALLLDFAKDERLPLKFTLELYNALNKEHFTNSPKKAFKLLKGIIKDKLHENLLSCVSYGFC QNAFSNTAFDKTDPLYCEDGSPKNEIEKHKIGKYKSAQTPSPNYLYETIIYDSKIEEEVSEEGVQTLEGKSIEVF AKLPKFKIPTPYKNYEPDFAYLLKDEKGAKIFFVCETKGYEKESDIPPDEKRKIEYAKKFFETLSQNLKNAKKEI RVVFATRINKQDLFNTLKNALKETP Helicobacter pylori NYSGXRC-6270b SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC3941 VMSDRQSFLYSGHKLSSGGANDPLLPRLVQAINHATEIEISVSFIQPSGLDLLFDPLFDAVQSGAQVKLLTSDYLS ITHPVALRRLMLLTERGAQCRVFECGQHSFHMKSYIFVRCEQGEILEGCAWIGSNNISKTALLDSHEWALRHDFE PPETSAAALEFLHIRQQFASIFNHTNSKDLTHTWIDHYLERYQQAKKQHGMPILADSQDEQSEPPAPNAVQVEAL TALNATRAQGFSRGLVVLATGMGKTWLAAFDALQTQSTKVLFVAHREEILLQAEKTFCQLIPNAKTGLYNGVTQN TQAMLLFASVATIGKQNHLQRFAADHFDYIVVDEFHHAAARSYRNLLTYFKPKFLLGLTATPERSDQADILSLCD SNLVFERNLVHGIDEKILVPFDYHGIYDQAVNYQEIPWRNGKFDPDSLDNALATQRRAEHVYQHWHQKKQTRTLA FCVSKKHADFMAEFCLSKGIKAIAVYSDSKVRRNQALQWLDSGKIDILFSVDLFNEGTDLPAIDTILMLRPTESK ILFLQQLGRGLRRSIETQKSKLVVIDFIGNHDSFLNRPTTLYNVSHLKDALAKHQQQALPDGCHVTFDITLLNFW QQLTRKMRFSVQDEYQQLAHQLAHRPTASEFFYHGIEISKVRKQAQSWFHLVASQENDPELAEIVTRYGDFLLHG IESTGMSKSFKAILLEALLELDGLRTPPTLATLAECSYTVIARRPDLMAEDLTENAKQFKAADKDWLNYWRNNPI KAFTNKATKQATWFSIDSQQRFVANFDIREQDLERLHDCIQELVDLRLAEYAQRPKQHKENLIKAKSKAAVISLI PEQKTIGTPIPFYPELKIACGHFKRGSEREVQTYFVPDGYGLLDPTRHFVSPASGNSMNGGKNPIQDGDLLLLEW VTPSSAGSISNLTMAIETQDETGDNQYLLRVVRKIAPNQYELQAQNPSYPNMPATDAMKTFARLKAVIKNNSQQS QTR Vibrio cholerae NYSGXRC-6271a SGX Pharmaceuticals 2004-01-22 active Selected EC1734 VSRIIMLIPTGTSVGLTSVAWRDPCNGTQRRSSERFQTYRSAAYRWRCADQTTTIVRANSSTTTAAEPLKMSYVEG LLSSNQKDVLMEEIVANYHANTKDAEVVLVEGLVPTRKHQFAQSLNYEIAKTLNAEIVFVMSQGTDTPEQLKERI ELTRNSFGGAKNTNITGVIVNKLNAPVDEQGRTRPDLSEIFDDSSKAKVNNVDPANVQESSPLPVLGAVPWSFDL IATRAIDMARHLNATIINEGDINTRRVKSVTFCARQHSAHAGALRAGSLLVTSADRPDVLVAACLAAMNGVEIGA LLLTGGYEMDARISKLCERAFATGLPVFMVNTNTWQTSLSLQSFNLEVPVDDHERIEKVQEYVANYINADWIESL TATSERSRRLSPPAFRYQLTELARKAGKRIVLPEGDEPRTVKAAAICAERGIATCVLLGNPAEINRVAASQGVEL GAGIEIVDPEVVRESYVGRLVELRKNKGMTETVAREQLEDNVVLGTLMLEQDEVDGLVSGAVHTTANTIRPPLQL IKTAPGSSLVSSVFFMLLPEQVYVYGDCAINPDPTAEQLAEIAIQSADSAAAFGIEPRVAMLSYSTGTSGAGSDV EKVREATRLAQEKRPDLMIDGPLQYDAAVMADVAKSKAPNSPVAGRATVFIFPDLNTGNTTYKAVQRSADLISIG PMLQGMRKPVNDLSRGALVDDIVYTIALTAIQSAQQQ Escherichia coli NYSGXRC-6271b SGX Pharmaceuticals 2004-06-30 active Selected EC1734 MDEDFRKAALDYHRLPRPGKLAIEATKRMATQRDLALAYSPGVAAPCIAIAENPELARDYTARGNLVAVISNGTAV LGLGDIGPLASKPVMEGKAVLFKKFAGIDVFDIEVDAKDPDRFIEVVAALEPTFGGINLEDIKAPECFVIERKLR ERMNIPVFHDDQHGTAIVCAAAVRNALLVQGKQLKDVKLVTSGAGAAALACVDLLVSMGLPVENVTLTDIKGVVH AGREPDMPDNMARYARQTDARTLPEVLPGADIFLGLSAPRVFKPEWLPLLAPNPLILAMANPEPEILPELVYESR PDAIMATGRSDYANQVNNVLCFPFIFRGALDVGASEINEAMKVAAVEAIAELARAEASEVVASAYGGAAPVFGSQ YIIPKPFDPRLILQIAPAVAKAAMDSGVATRPIADFDAYQAELELFVYRSGQLMRPVFERARKQPVKVAYAEAED ERVLRAVQTVVDEGLAYPVLVGRREVITGKIEELGLRLAGKVEIIDPQADKDLFAPLIADYQRLVGRRGVPPIAA ERRVTGRRTVAASMLLATGYVEAALVGGSGDWWQHMKYALPIIPRRDNVSRVYAMSSLILDKGTLFFCDTHVNVD PTAEQIAECTQLAAEAVRRFGLTPKAALLSHSSFGASDSPTARKMREALALLRTQAPDLEVDGEMHADAALSQHL RDRMVADSPLKGSANLLVMPTLDAANIGLTLLSAATESLLVGPVLLGMAKPLHVLIPSVTARGIVNLTALAVNQA VSERAAS Caulobacter crescentus NYSGXRC-6271c SGX Pharmaceuticals 2004-01-22 active Selected EC1734 LAGPIPFFLPLSPPVPKESRMKTLFLAPTRNGVGLSSTALGLARALERQSLKVAFLKPIAQTYEPRTDDSVHFARA VAHLTTPDPIPLTRAEELLSQGGEEDLMEQVIALAREAAGEGSDVLIAEGLALNERNVYAGTLNARLARNLEADT VLVSSLAGVTPAELADELEIAAQGYRRSDGSGLAGFVLNFAPRELDFGSLMAELRSRSRVLASGELPLLGVVSLD PALRQLRTLDVARALDAEIINAGEAESRRVSSTVVTARSVPQMTNLFTSGALIVTPADREDVIMAAALSHLSGTP LAGLMYTSGSAPEATIQQLCEVALTSSLPVLRVPTNSFETASRLVHLDFRVPHDDPRRMDRMLDYIADRLDTVPL GARLRAPGVAGERRLPPSAFRYELIQRARAANKRIVLPEGDEPRTVKAAIRCTEKGIARCVLLAPPEKVRQVAQG QGLELPEGLEIIDPETVRGKYVAPMVELRKSKGLTEPQAEAQLEDSVVLGTMMLALGEVDGLVSGAVHTTASTVR PALQLIKTAPGSSLVSSVFFMLMPEQVLVYGDAAINPDPNAQELADIAIQSADSAHAFGIPVRVAMLSYSTGESG SGEDVEKVKEATKLVRERRPELLVDGPLQYDAASVPSVGRSKAPDSPVAGRATVFIFPDLNTGNTTYKAVQRSAG VVAVGPMLQGLRKPVNDLSRGALVDDIVYTIALTAIQATQSAADCG Deinococcus radiodurans NYSGXRC-6272a SGX Pharmaceuticals 2004-07-19 active Selected EC459 MLVMRPAQAADLPQVQRLAADSPVGVTSLPDDAERLRDKILASEASFAAEVSYNGEESYFFVLEDSASGELVGCSA IVASAGFSEPFYSFRNETFVHASRSLSIHNKIHVLSLCHDLTGNSLLTSFYVQRDLVQSVYAELNSRGRLLFMAS HPERFADAVVVEIVGYSDEQGESPFWNAVGRNFFDLNYIEAEKLSGLKSRTFLAELMPHYPIYVPLLPDAAQESM GQVHPRAQITFDILMREGFETDNYIDIFDGGPTLHARTSGIRSIAQSRVVPVKIGEAPKSGRPYLVTNGQLQDFR AVVLDLDWAPGKPVALSVEAAEALGVGEGASVRLVAV Pseudomonas aeruginosa NYSGXRC-6272b SGX Pharmaceuticals 2004-08-11 active Selected Cloned Expressed Soluble Purified EC459 ICEDB: T1962 GENBANK NP_288180.1 MMVIRPVERSDVSALMQLASKTGGGLTSLPANEATLSARIERAIKTWQGELPKSEQGYVFVLEDSETGTVAGICAI EVAVGLNDPWYNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAF RDKFNDKVVAEMRGVIDEHGYSPFWQSLGKRFFSMDFSRADFLCGTGQKAFIAELMPKHPIYTHFLSQEAQDVIG QVHPQTAPARAVLEKEGFRYRNYIDIFDGGPTLECDIDRVRAIRKSRLVEVAEGQPAQGDFPACLVANENYHHFR VVLVRTDPATERLILTAAQLDALKCHAGDRVRLVRLCAEEKTA Escherichia coli NYSGXRC-6272c SGX Pharmaceuticals 2004-12-10 active Selected Cloned Expressed Soluble Purified EC459 ICEDB: T1963 GENBANK NP_232245.1 VSNAEITHREGVKMLVVRPISMADYEALHTCAVESGHGFTSLPVDQELLTNRITHSEYSFSKPNVTMPGDEGYLMV GVDTETGQVAGTTGIEASIGWDVPFYSYHISTIVHSSPKLGVNNVVKLLTFGNNYTGCSEICTLFLRPQYRQGLN GRLMSKCRFLMMAEHSHRFSKTIFAEMRGVSDADGNSPFWKWLQEHFFSIDFTLADYLTGIGKKGFIADLMPKLP IYVNLLSKEAQAVIGQVHENTRPALVLLEKEGFTCRNYVDIFDAGPTVECELNNIESVRHSVRAIVEVAEHSSSQ NFIMCNTSFENFRATAAKAAYSQEDNAVIISPKVAAALEVSTGDYLRILAQ Vibrio cholerae NYSGXRC-6273a SGX Pharmaceuticals 2004-07-30 active Selected Cloned Expressed Soluble Purified EC812 ICEDB: T1964, T660, T677 GENBANK NP_418448.1 PFAM PF00696 MSEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPCERFEKLDAIRNIQFAILE RLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDR FGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGI YTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRA LALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSA LCRVEVEEGLALVALIGNDLSKACAVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE Escherichia coli NYSGXRC-6273b SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC812 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPRPPEREMDTLLAVGEQK AIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRG GSDTTAVALAAALKADCEINTDVPGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIH VRSTFSEEEGTWIVPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGY TDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILARNGINIKAISTSE IKISCLIDEKYAELAVRALHEEFIEEMEEFETINGKNKE Aquifex aeolicus NYSGXRC-6273c SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble Purified EC812 ICEDB: T1965 PFAM PF00696 GENBANK NP_230045.1 LLYKKHSLHNIGRWVTNNSFFRKSGRIAVSTFNVAKFGGTSVANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLL VELANGVASTERRQAILQQLADIHYVIIDQLADPTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGELIS TYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQLKEIAQLAKEKLVPLCEQYVVVTQGFIGSDAQGNTTTLG RGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAPIPEISFSEASEMANFGAKILHPSTLLPAVRHGI PVFVGSSKEPEKGGTWIRKQVESAPLYRALALRCNQTMVTLRSAQMFHAYGFLAKVFEILAKHKISVDLITTSEI SVSLTLDKTDTSGGAPELPEAVRAELEELCTVEVEYNLCLIALIGNKMKESRGYAKQVFSVLEDYNLRMICYGAS AHNLCFLLHESVSKQAVQKLHKELFEQE Vibrio cholerae NYSGXRC-6273d SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC812 MTEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGMEPGERFATLDAIRKIQFDILD RLRHPNVIREEIERLLENITILAEAASLATSAALTDELVSHGELMSTLLFVEILRERDVQAHWFDVRKVMRTSDR FGRAEPDVAALAELAAQQLLPRLSETLVITQGFIGSESKGRTTTLGRGGSDYTAALLAEALHAARVDIWTDVPGI YTTDPRVVPVAQRIDEIDFEEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPQAGGTLVCNKTQNPPLFRA LALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSA LCRVEVEEGLALVALIGNNLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGDDAEKVVQKLHQNLFE Salmonella typhi NYSGXRC-6273e SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC812 LKVLKFGGTSVGDAERIRSVARLITSVKGRKIIVLSAMAGTTNSLVEIASHLVKRNVAQAKEVVQVLREKYHREIN ALYKRPDTLSAAKKAVDSLLDSLGHMCDVEGFTLFEEKRVLILGELMSTTMMQIYLQEMGAVVAMLPALEYMRTD KNAEPDKDYIRKHLLPMIEAHPDEDMLFLTEGYICRNAFGEIDNLQRGGSDYTASLIGAALNADEIQIWTDIDGM HNNDPRVVDVTAPVRRLHFEEAAELAHFGAKILHPTCIKPAKEKNIPVRLLNTMDPDAPGTLISLDTEKDCIKAV AAKDGITVIKVKSSNKLLSWHFMRKLFEIFEFYQEPVDMVATSEVGVSLTIDNDKNLPDIVRALSDIGDVTVDKD MVIICIVGDMEWDNVGFEARIINALKGVPVRMISYGGSNYNVSVLVKAEDKKKALIALSNKLFNSRATKA Porphyromonas gingivalis NYSGXRC-6273f SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble Purified EC812 GENBANK NP_285694.1 MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDALPNISDAERIFAELLT GLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPV EKLLAVGHYLESTVDIAESTRRIAASRIPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRDE DELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISFCVPQSDCVRAERAMQE EFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTG VRVTHQMLFNTDQVIEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELA QAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHLLRHAAEKSRR KFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLAREMGYTEPDPRDDLSG MDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDE DGVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV Escherichia coli O157:H7 NYSGXRC-6274a SGX Pharmaceuticals 2004-06-30 active Selected EC1778 LYWRVCALFAYSVNSEQKTATSEMTDVSRLMPVKIKQTVKGQEEEMLIDTVKEANRKNIKFSIAGAQHSMGGHTYY EDGIVLDMTGYNKILSLDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGSL IDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTEKMNYSTYSDYFSKHVKGN PDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSELKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYF LSQNGTEISRNNVMRSESKFLEYENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKAD LSYAKDDMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPKSEAFFQKKRTY DPDERFMNYFYQRYK Bacillus subtilis NYSGXRC-6274b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1778 GENBANK NP_282360.1 MKKEFEQYFKRFLGEENAYFDEIHKRAYSYDATKKHYLPDGVLFPRNEEDIARILKFCNENNIIVIPRGSGSGFTG GALAVNGGVVLAFEKHMNKILEIDLENLVAVVQPGVINIHLQKEVAKYGLFYPPDPASMEYSSLGGNVSENAGGM RAAKYGITKDYVMALRAVLPSGEIIRAGKRTIKDVAGYNLAGILIASEGSLAVLSELTLKLIPLPKFKKTAFAIF PSVKSAMNAVYKSLASGVSPVSMEFLDNLSIRAVESKFNKGLPIEAGAILIADVDGNVKEAIDEDLRNLEHYFLE AGASEFKIAKDEQETADIWFARRNCSQSIAMYGTLKLNEDITVPRSKLPTLLEGIDEISKKYGFKIPCFGHTGDG NVHTNVMVPDKNDKEQVKKGYEAVEEIFKLTVKLGGTLSGEHGIGLSKAPFMNLAFSEAEMNLMRNIKKAFDPNN ILNPFKMGL Campylobacter jejuni NYSGXRC-6274c SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble Purified EC1778 ICEDB: T1966 GENBANK NP_111115.1 MGFIEEIKSALGNYVITEKKDLIPYMNDASYFTGEMPEAVVLPGSAEDVQTIMRLAYKYEKPVVVKGGGSSLTGSS ILKESGIVMSMLRMNRILDINLNDKCVTVEPGLRLNDLQLYLDKYGHFYPPDPASSMAATVGGSISTNAGGLRGV AYGVTKDWILGLDVVLADGTMVKFGNKTLKRTLGYDLTSLMIGSEGTLGVITKAYLKIWPKPQKVARLVAFYQDI ESAGRAVNELKVSTIPEMAEFLDKISLDSVPEAITYPPGTKYALIIDVSGPPELLGKKKTETEELLKRYAISTKS TTDPAEMEKIYRARKGLYASILKLRKSEKEYIVIGDIVVPVSELPTSLKEIEKKRDEDGVRAAIFGHIGDGNIHA NIFADLGDNSAMDKVNRFMMDLAMVAVKHGGSVSAEHGIGIEKKQLLIEEMKYNNNLRTLDIMKAIKQVFDPKNI LNRGNIFE Thermoplasma volcanium NYSGXRC-6274d SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC1778 GENBANK NP_344472.1 VISKLAEIVGEEWVISGDEAKLYSYPAFIPLKIEPPVVVLPGSEEEVISLVNFLNENNIKYIVRGSGTSLSGATTP TQGEVVISLTRLNRIYSLDNFEITVGPGLANFLINKTLGNSNLFYAPDPSSYVVSSIGGNISHDSGGMHTPKYGT TFDSIIRLKVLLSNGHVEEIGSSNFFDPTSIFVGAEGTLGVILRATLRLFPKPEVSKTILASFNSIDDAGKAVVS VYKAGVTPAAMEFLDKNSIIAIENTQYKANYPMAEAILLIELDGYSVNVEEEEVRVVSAIRNNNGEVFIPKDEEE KNRWWWGRKGAFPSFAYYSPAYLTLDANVPRSTLPTMLRFTYEISKKYGLPVANSFHAGDGTLHPLIGFDPKNAD ETIKAIKAAEEITKLAIKVGGVPSGEHGIGIEKIKFMKLYYSEDDLTLMRRLKATFDPKRLLNPCKLIPPAKNEI CNTVNRIHTYLLEGDI Sulfolobus solfataricus NYSGXRC-6275a SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble Purified EC881 ICEDB: T1967 GENBANK NP_370577.1 MSNLINGKIPNQAIQTLKIVKDLFGSSIVGVYLFGSAVNGGLRINSDVDVLVVVNHSLPQLTRKKLTERLMTISGK IGNTDSVRPLEVTVINRSEVVPWQYPPKREFIYGEWLRGEFENGQIQEPSYDPDLAIVLAQARKNSISLFGPDSS SILVSVPLTDIRRAIKDSLPELIEGIKGDERNVILTLARMWQTVTTGEITSKDVAAEWAIPLLPKEHVTLLDIAR KGYRGECDDKWEGLYSKVKALVKYMKNSIETSLN Staphylococcus aureus NYSGXRC-6275b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC881 GENBANK NP_814808.1 VVHQLLAQMENGYMKIIKENLVGIYLHGSYAFGTYCHSVSDLDVLIVVYEKLTIDEKKQLLDYTINILDKWAPKKG IEFHVLQLKDTINLSYPIPFDLHFSPIHRSRYLTNKNKYIEDMMGYDEDLVAHLMITKLYGKVLVGKPIDSVFGW IDQKKYFESIVADVKEAKKEIVQQPMYVILNMCRVMAFKQENKILSKRAGGEWGLVHFPTNHHSLIQLALKEYRG ETVLLEQYNDSELNDFADIMLSLLFK Enterococcus faecalis NYSGXRC-6275c SGX Pharmaceuticals 2004-07-27 active Selected Cloned Expressed Soluble Purified EC881 ICEDB: T1968 GENBANK NP_069136.1 MHEKLLELSRELKEKFKDEIIEIIVFGSYARGDLDEDSDIDILVVVNDDSVEDDLRKAAYSFIPKIGRLISVKIID KKTFENMKKMEFSLISSIEKEGIKIG Archaeoglobus fulgidus NYSGXRC-6275d SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC881 ICEDB: T1969 GENBANK NP_342700.1 MSIIEVLEENKRLRDNYIKNLNFYLDRIKEVVKNIDPSTKIILFGSYIRGNFRPDSDIDVLIITNVSNEFDRLKIY HEVNKAIGNPNPFEIHVINEEEYVSWYSKFLDVYKEV Sulfolobus solfataricus NYSGXRC-6276a SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC4933 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWL SPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAM EQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWG QMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHL TTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAAN RCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS Mycobacterium tuberculosis NYSGXRC-6276b SGX Pharmaceuticals 2004-06-30 active Selected EC4933 VVLLKGFEIEMYTGTPQGEIVGLSDKIVTQLDGFVREPDSRNVEYTTDPLHSYENLLCALLRPRRALRDYLKQLGD YTLIPGSTLSLGRSDRFFRSDPANPYHDYIEQTYGTKVVTASVHINVGIDDPEVLMRACRLIRVEAPLFLALSAS SPFIDGKATGYHSTRWGVFPQTPTNVPLFTSHAHHIEWVEQQLAIGTMQNVRHLWVSVRPNGDRRPYDLNRLELR ICDLVTDPISLLAITALLEARLLQLIENPDLDPLTQSKFSPEELVTLTAKNEAAAASASLDAQLTHWQDGRSIIA RDWVNEIYQEVWAIAKKHGFSCFLSPLQKILREGNEAQHWLQLHKVGFDTQCVITQAISTTQERELELQNKLCTQ LKG Nostoc sp. NYSGXRC-6276c SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC4933 MADTASVQERQLTLDDLTAYFAKGSKPKEAFRVGAEHEKFGFYLGSHEPVPYEGDKGVHALLTGLQRFGWTPVMEG PTIIGLERNGANVSLEPGGQFELSGAPLSTMHEICEETGQHLDEVKTVADELGLGFTGLGFSPKWTRGQVPIMPK GRYVIMRNYMPKVGNLGLDMMLRTCTVQANLDFSSEADMVAKFRMSLALQPIATALFANSPFTEGKPNGFLSARA NVWTDTDPNRTGLLDFVFEDGFDFERYARYALDVPMYFVKRGDKYIDVAGRSFRDFIEGKLPELPGEIATMKDFA DHTTTAFPEVRLKTYLEMRGADAGPWSRLCALPALWTGVFYDDAALAAAWDLCKDWTLEDREGLRRDVPKLGLKA QVAGRSAQDVAKDFVAVAKAGLKNRAQLNGGFLDETIYLGELEQIADSGITPAEKLLSLYNGAWGGDIERVFTDC AY Caulobacter crescentus NYSGXRC-6277a SGX Pharmaceuticals 2004-07-19 active Selected EC2167 MPVEHLDVLIVGAGLSGVGAAYHLMKHCPGKSFALLEGRAAMGGTWDLFRYPGIRSDSDMFTLGYNFKPWSDPKAI ADGPSIRRYIEETARENGIDRKIRYRHRVLRADWDSANARWNLDVQRGDEPEPLRMTAQFLLMCTGYYRYEAGYT PEFVGREDFAGQVVHPQLWPEDLDYSGKKVVVIGSGATAVTLVPSLTDKAAHVTMLQRSPSYVITLPQKDAISNF LRRFLPETWIYRQARARNVAMQMVFFMLARTFPGLVRKALLKLASLQLGKRFDIRHFSPRYKPWDERVCAVPDGD LFKVLRKGKASVVTEHIDRFVERGIRLKTGEVLEADIIVTATGLDLVMFGGAELAVDGKPFLVNQSMGYRGIMLR DLPNLAAVVGYTNASWTLKADLSSEYFCRLINHMDATGMRQVTARDSTGDVREEPFLNLDSGYIQRAAERMPKQG DRMPWKLYQNYVLDLALLRYGKVEDGYLVFSSPAPQRQAGGAAVQALG Pseudomonas aeruginosa NYSGXRC-6277b SGX Pharmaceuticals 2004-12-03 active Selected Cloned Expressed Soluble EC2167 GENBANK NP_421371.1 MAMEHVDVLIVGAGLSGIGAAYHLQKHCPGKTYAILEGREAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWKAAKAI ADGPSILDYVRETAREHDIDRHIRFQHLVKRASWSSETATWTVEAEHDGKPVTLTCRFLHMCSGYYRYSAGYTPD FAGTERFKGRIVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPEMAKTAAHVTMLQRSPTYVVSRPAEDGIANWLR SKLPAMTAYGITRWKNVLFQLFFFNLARKKPEKVKERLLGMVRDHLGPGYDVETHFTPRYNPWDQRLCLVPDADL FDAIKSGAASVVTDHIETFTETGIQLKSGKTLDADVIVTATGLQLQLLSGMEVVVDGKVADLSQSMSYKGMMFSD VPNLASVFGYTNASWTLKADLTSEYVCRLLNHMDRTGADYCVPRLDGEVEAAPWLDFSSGYITRSIGHFPKQGTR KPWKVHQNYALDLMTLRMGKVEDGVMQFGRKTGATAKAKPEKALEPA Caulobacter crescentus NYSGXRC-6278a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC893 MPQVDPELFDRGQFQAELALKSSPIAAFKKAIRQFREVLDNRFNSGRDIRRLIEDRAWCVDQILQQAWQRFDWGDD ADIALVAVGGYGRGELHPYSDVDLLILLDSEDQESFREPIEGFLTLLWDIGLEVGQSVRSVQQCAEEARADLTVI TTLMECRTICGPDSLRQRMLQVTGSAHMWPSKEFFLAKRHEQQRRHAKYNDTEYNLEPNVKGSPGGLRDIQTILW MARRQFGSLNLHALVREGFLVESECSMLASSQEFLWRVRYALHMLAGRAEDRLLFDHQSQHRPSVRLRRQRRQTG GRTLHAEVLPGGDGDLRAERPDHPALRGSHPALRAAGADPAAEQSLPVARRLHRGDAPERLQAHSVRPPGNLRAD GPAPGNQGRARRHHSPAARQPTPDRRRVPPRHPQHQPVHRAVQEQPGYPPQPAADEPLRHPRPLPAGVRPYHRAD AARPVPYLYGGRPHPQPDQAPAQAESAGDGREISAGEQDHRSSAQAGTDLHRRSLPRHRQGPWRRPLGTRRGGRR GLLPEPPVAALGHPTGVLAGAEPPGDVDHRATQGPLRPAGDLRFRPTGRRPDPPRLPVRAHRGRHQRHQPDALEL LARQPAPAALHRDQARPAPRPGEPGGPRGADPPDADRGPRPTGTQRHRPGRCRAVMEPARRRLLPAPHRRRRGLA HRGDPPAPGRRHAAGADQGNHPARVRERFADLHLRRRPARFLRGHRGRHGPAQPEHPGRADHHLHQPVHPRYLYR ARADGDSIGNNPERIAEIREGLIDALKNPDDYPTIIQRRVPRQLKHFAFAPQVTISTDAVRQVSVLEVIAPDRPG LLARIGGIFLDFDLSVQNAKIATLGERVEDVFYITDARNQPLADPDLCKRLQAALVEQLSQDNGRDTLPTRINF Pseudomonas aeruginosa NYSGXRC-6278b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC893 GENBANK NP_470772.1 MTIAITIISSLLFLIVGLVVGSLIFKSSTEKKLAAARGTAELIVEDAKKEAETTKKEALLEAKEENHRLRTEIENE LRGRRTETQKAENRLLQREENLDRKDTSLSKREATLERKEESISKRQQQIEEKESKLAEMIQAEQTELERISALS KEEAKSIILNQVEEELTHDTAIMVKESENRAKEESDKKAKNILSLAIQRCAADHVAETTVSVVTLPNDEMKGRII GREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARIALEKLVQDGRIHPARIEEMVDKARKEVDEHIRE VGEQATFEVGIHSIHPDLIKILGRLRYRTSYGQNVLNHSLEVSKLAGILAGELGEDVTLAKRAGLLHDIGKAIDH EIEGSHVEIGVELATKYKENDVVINSIASHHGDTEATSVIAVLVAAADALSAARPGARSETLENYIRRLEKLEEI SESYDGVEKSYAIQAGREVRIIVEPDTIDDLSSYRLARDIRKRIEEELDYPGHIKVTVIRETRAVEYAK Listeria monocytogenes NYSGXRC-6278c SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC893 MEFNVLFISILLVVSAVSAVVGYLVRKSIAEAKISSAEHAAKQIVEDAKREAEAGKKEAILEVKDEVHKLRTEAER EIRERRNEIQKQENRLVQKEEILDRKSETLDKKEESLDKREESLTKKQRQIEEMDSKVEEILNKQQVELERISGF SREEAREVIRAEVEQEMAHETALLIKERVAKAKEEADKKAREILSLAIQRCSADHVAETTVSVVNLPNDEMKGRI IGREGRNIRALETLTGIDLIIDDTPEAVILSGFDPIRREIARTALEKLVQDGRIHPARIEEMVDKARREVDEAIR EYGEQTTFEMGIHGLHPDLIKILGRLKFRTSYGQNVLKHSMEVAYLAGLMAAELGEDVKLARRAGLLHDIGKAID HEVEGSHVEIGVELATKYKEHPVVINAIASHHGDTEATSIISSLVAAADALSAARPGARRETLETYIRRLEKLEE ISESFDGVEKTYAIQAGREVRIMVKPDIVDDVLAHKLARDITKKIEEELDYPGHIRVTVIRETRAVEYAK Bacillus halodurans NYSGXRC-6278d SGX Pharmaceuticals 2004-07-19 active Selected EC893 MHKAVEFVLYLLWDLGFKVGHATRTVDECIRLSKSDMTIRTAILEVRAICGRKSLTDDLEKRFESEVVTGTGPEFI AAKLAERDQRHRKAGDTRYLVEPNVKEGKGGLRDLHTLFWIAKYYYHVRDTADLVKLGVLSRSELKLFEKADDFL WAVRCQMHFITGKAEERLSFDIQREIADALNYQPRPGLSAVERFMKHYFLVAKDVGDLTRIVCAALEDRQAKDVP GLSGVLSRFAHRVRKIPGSVEFVEDRGRIALARPDVFKNDPVNLIRLFHIADINNLELHPDALRVVTRSLSLIND ELRENEEANRLFLSILTSRRDPALTLRRMNEAGVLGKFIPEFGKIVAMMQFNMYHHYTVDEHLIRSVGVLSEVDK GTAVDAHPLANQLMPGVEEREALYVAVLLHDVAKGRQEDHSIAGARVARKLCQRFRLTGKQTETVVWLIEQHLLM SMVAQTRDLHDRKTITDFADKVQSMERLKMLLILTVCDIRAVGPGVWNGWKGQLLRSLYYETELLLSGGFSEVSR KERAQIARQALYDALEDWGQKARRKYTKLHYEPYLLTVALEDQVRHTRFMREADKQEKALSTMVRTHSFHAITEI TVLAPDHPRLLSIITGACAAAGANIADAQIFTTSDGRALDTILINREFPIDEDETRRGANVGKLIEEVLSGKQRL PEMIATRTKSRRKKSAFTIPPSVTISNGLSNKFTVIEVECLDRPGLLADMTAVIADLSLDIHSARITTFGEKVID TFYVTDLFGQKVTNDNRQASIAQRLKAVMSEQEDELRDRMPNGIIAHPDVAALPAARTAKA Agrobacterium tumefaciens NYSGXRC-6278e SGX Pharmaceuticals 2004-07-19 active Selected EC893 MHTAAAATPATSPRDILKAERAHLFAQFEQHANVNLLVTKLARAVDQALILLWQDEGMPDTCALVAVGGYGRGELF PHSDVDILLLLPQTADKALETRLEAFIGHCWDMGLDIGSSVRTVDECISEATQDVTVCTSLLEARLLTGDEGLYR TFETHYQGHLDAADFYQSKMLEMRQRHAKYQDTPYSLEPNCKESPGGLRDLQVILWMTRAAGFGSSWNELLVNQL LTRREAKELAANERLLKTIRARLHLLAGRRQDVLVFDLQTQLGEAFGYRPNAAKRTSEQLMRRYYWAAKAVTQLN TVVLQNIEARLFPTELGITRTINGRFVERQGMLEIADPELYQREPAAILETFLVYEQTRGVKGLAANTLRALYNA RTQMDARWRRDPANRATFLSILQQPQGITHALRLMNQTSVLGRYLVNFRRIVGQMQHDLFHVYTVDQHILMVVRN VRRFAIVEHAHEFPFCSQLMANFDKPWVLTVAALFHDIAKGRGGDHSVLGMADARRFCKQHGIASEDADLIVWLV EHHLTMSQVAQKQDLGDPEVIRHFADQVGSERYLSALYLLTVADIRGTSPKVWNAWKAKLLEDLYRITLRVLGGA TTDPHAVLEGRKEEARVLLRLAAMDPHAHEALWAQLDVGVFLRHDARDIAWFTRHFYNRVDTTLPIVRARISPVG EGLQVAVYSPDRPDLFARICGYFERKGLTILDAKIHTTKHGYALDTFQVADPGSGLVEPGHYRDIITLVEHELAE LIARETVLAEPPRGRISRQSRSFPIKPRVDLRPDERGQYYLLSLSATDRTGLLYAIARVLARHRVSVHTARINTL GERVEDVFLLDGRRLTQDNKLQLALESELLEALAI Ralstonia solanacearum NYSGXRC-6278f SGX Pharmaceuticals 2004-08-10 active Selected Cloned Expressed Soluble EC893 GENBANK NP_816774.1 MVLNILLAIVGLIVGLGLGFVIAKSRHDKAINGAKISASSILENARKESETLKKEALLEAKEENQKYRSEIESELK ESRLELKSQENRLIQREQTLDRKDDSLEKREGSLEEKEEKLGARQQLIDEREKEVENLINQQHQELERIASLSKE EAKSIIMKSTEEELNHELTLMVKESEQRAKEESDRKAKNLLSLAIQRCAADSVSETTVSVVTLPNDEMKGRIIGR EGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPIRREIARMTLEKLIQDGRIHPARIEEMVEKSRKEMDERIREYG EQAAFEVGAHTLHPDLIKILGRLRFRTSYGQNVLNHSIEVAKLAGVLAAELGEDVQLAKRAGLLHDIGKALDHEI EGSHVEIGAELAAKYKENSVVINAIASHHGDVEATSVISVLVAAADALSAARPGARSESLENYIRRLENLENISN SFEGVDSSFAVQAGREVRVMVKPEEISDLESVRLVRDIRKKIEDDLDYPGHIKVTVIRETRAVDYAK Enterococcus faecalis NYSGXRC-6278g SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC893 MLFSPTLSSLLTPSAVKIERENLKQFELENFSCYSIFELIENRCDFYDALLIQLWQEIGLSEQQGISLIAVGGYGR REMFPLSDLDFLILVEQTPSHEIEEKITQFIQFLWDCGFEVGNSVRTLEQCELEGKQDITIATNLLEARFLTGNR PHFDVLNELVKRADFWSKEDFFNAKVQEQIERYQRYHNTAYNLEPDIKFSPGGLRDLHLLYWVALRHSGALTLEA ILQSGFIYPQEYQQLQESRAFLFKVRFALHLILKRYDNRLLFDRQIKVSELLGFRGEGNPAVEKMMKCFFQALHR ISLISNLLIQHYRENVLSSNQDTVIDQLDDDFQLINQSLCLRNSFVFQEKPARILDLFFYLTQYEHVNIHSDTLR QLQISLEQLSQKLCEIPAAREKFLRLFNQSNAIKRAFMPMHQYGVLTAYLPQWQAIEGLMQFDLFHIYTVDEHTL RVMLKLESFLPKGSAQEHPIAHRIFSQLSDRTLLYIAALFHDIAKGRGGDHAELGAEDVADFAQLHGLDRREIDT LAWLVQSHLLMSITAQRRDIHDPEVVMNFAEAMQNQVRLDYLTCLTVADICATNGNLWNSWKRSLFASLYEFTEQ QFSQGMKELLDYSEKSAENRKLAQQILTQDYSDITSISIEKLWTRCPEDYFVRNTPKQIAWHTSLLVDFVEALLV KISNRFSLGGTEVFIYCQDQPHLFNKVVSTIGAKKFSIHDAQIITTQDGYVFDSFIITELNGELVEFDRRRELEQ ALTVALQSEKLPALSIVPNRQLQHFTVQTDVRFLQENKKEHTEMELVALDKAGLLAQVSQIFTELNLNLLNAKIT TVGEKAEDFFILTNQFGQALAREERERLNSVIIQQIR Haemophilus influenzae NYSGXRC-6278h SGX Pharmaceuticals 2004-06-30 active Selected EC893 MPANLSSALETFKQQRDAAEAHYLKANRVSVFFREYTAAVETLLAALWAEYFQNSALCLMAVGGFGRGELYPCSDV DLAVVSPAPLSDGIQEQIARFVQTLWDCKLMPSVKSGSVDELCESVRNDITGDTAFLEARFLFGNRQTVDKLAEK MNAQRNVAAFVEAKLVEMEHRHAKSQGSGAVLEPNIKSCPGGLRDIHTLLWIAKAQGLATDLPDLLKQRILTRAE AGMLSHGYRRLAHIRIHLHLNAKRAEDRLLFDLQPQVAESMGYEGLNLRRQSEELMRVFYRAIKTVKQLGGILTP MLQSRVSSTPLRVTLRIDDDYIQVNNQIAARHTDIFFRRPEHIFKIVEIMQQRNDITALEPQTLRAWWGATRKIN RSFYQNPENRRRFAGFFRNGNGLTQTLRFLNLYGVLGRYLPAWEKIIGLLQHDLFHIYPVDDHILTVVRNVRRLA LDMHSHELPYASALMQSFEKQDILYLAAFFHDIAKGRGGDHAIQGIADARQFAADHFLTGEESDLLAWLVENHLL MSAVAQKEDIQDPSVLDAFCKRVQTHERLSALYLLTISDIRGTNPKLWNAWRASLLESLFHAAGRYLTGNGGNPH TLFGRRRQEAADLLTRAAVPEKQQKKLWNALGSAYFARHQSREILWHAANLVHDFETPIVRSRILPKSDSFQVMV FMPNGPRLFARLCRIFSRHGFDILAARAFITEHDYILDTFIVQIPSQHAPEDYPDIQSALEAELNSFIHGHTVAE TQSRSRRISRRSRYMPIAPSITITPEEDYPDWYSVEITAVNRPFLLADMAEVFFAHNVSLRYAKISTLDERAEDS FTVFSPDLKNPKIQSSLKQTLLEQLS Neisseria meningitidis NYSGXRC-6279a SGX Pharmaceuticals 2004-10-26 active Selected Cloned Expressed Soluble Purified EC2474 ICEDB: T1970 GENBANK NP_370706.1 PFAM PF00696 MKFIVIKIGGSTLSDMHPSIINNIKHLRSNNIYPIIVHGGGPFINEALSNQQIEPHFVNGLRVTDKATMTITKHTL IADVNTALVAQFNQHQCSAIGLCGLDAQLFEITSFDQQYGYVGVPTALNKDALQYLCTKFVPIINSIGFNNHDGE FYNINADTLAYFIASSLKAPIYVLSNIAGVLINDVVIPQLPLVDIHQYIEHGDIYGGMIPKVLDAKNAIENGCPK VIIASGNKPNIIESIYNNDFVGTTILNS Staphylococcus aureus NYSGXRC-6279b SGX Pharmaceuticals 2004-10-26 active Selected Cloned Expressed Soluble Purified EC2474 ICEDB: T1971 GENBANK NP_349004.1 MKKMQEPIEDPLSKLTQYSGKTFVIKYGGSIMKNKKAEEAFIKDVKYLRKLGINIVIVHGGGPEISRWLELSGIES RFVDGLRVTDEKVIEIVQMVLSGKINKKLSLQFNIDGVNAVGLSGVDNKLIEATKKYVYKGNETIDIGYVGKVTK VNSEFIKELLKGGQVPVIAPIGCDNKGNVYNINADYAAAFISSALDAEKLIILTDVEGVYRNINDPQSIIHEIDI KDVNYYIKEEIIKGGMIPKVQCCASAIENGTKNVQLIDGRNDHCLINDILNYRGTIISYRSGVKCQKAI Clostridium acetobutylicum NYSGXRC-6279c SGX Pharmaceuticals 2004-07-19 active Selected EC2474 VRWVSMRVIKVGGSVLENLEKVFKPEIFRDAVVVHGGSRYVDELAKKLGLNVEKLTSPSGVTFRRTTRKVLDVYIA AVMKANRELVSFLRRQGIEAIGVSGVKEVIIGRRKKLIKAVINGKIMAIRDDYSGIIKEVNVEMIRNYMKVGVPV IAPIAYDPVENVPLNVDGDKVAYHVALALKSRELYFLSDTAFLINGEVIDKIPRNRIEEYFPYSSGGMRKKLLMA KKAIESGVERVIIEGLNGRTVIS Pyrococcus horikoshii NYSGXRC-6279d SGX Pharmaceuticals 2004-07-19 active Selected EC2474 MHANLQTRQIIIRLLSSMASTKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDVDALTSSLSFLQEVGLTPIVLHGA GPQLDEELTAAGIQKKTVNGFRVTLPETMAIVRKVFHTSNLQLIEALQRNGARATSITGGVFEAHYLDQETYGLV GEISAVNLAPIEASLRAASIPVIASLGETPSGQILNINADVAANELVHVLQPYKIIFLTGTGGLLDADGKIINSI NLSTEYEQLIQQPWVYGGMKLKIEQIKHLLDRLPLESSVSITRPADLAKELFTHKGSGTLVRRGERVIRATTWKD LDLPRLQHLIQSSFRRTLIPHYFETTPLLRAYVSENYRAAVILTKLGNVPYLDKFAVLDDAQGEGLGRAVWSIMR EETPQLFWRSRHNNQANAFYYAESDGYYKQDHWKIFWNGLHHFQQIQQCVAHCAQHPPTLID Xylella fastidiosa NYSGXRC-6280a SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble Purified EC999 ICEDB: T1972 GENBANK NP_011909.1 MPQFSVDLCLFDLDGTIVSTTTAAESAWKKLCRQHGVDPVELFKHSHGARSQEMMKKFFPKLDNTDNKGVLALEKD MADNYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGSPYLAFSWFETILKNVGKPKVFITGFDVKNGK PDPEGYSRARDLLRQDLQLTGKQDLKYVVFEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVS VVKNNENGIVIQVNNPLTRD Saccharomyces cerevisiae NYSGXRC-6280b SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble Purified EC999 ICEDB: T1973 GENBANK AP_002893.1 MPEEARVRCKGFLFDLDGTLVDSLPAVERAWSNWARRHGLAPEEVLAFIHGKQAITSLRHFMAGKSEADIAAEFTR LEHIEATETEGITALPGAIALLSHLNKAGIPWAIVTSGSMPVARARHKIAGLPAPEVFVTAERVKRGKPEPDAYL LGAQLLGLAPQECVVVEDAPAGVLSGLAAGCHVIAVNAPADTPRLNEVDLVLHSLEQITVTKQPNGDVIIQ Escherichia coli NYSGXRC-6280c SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC999 MPEEAHVQCKGFLFDLDGTLVDSLPAVERAWCSWADRFNLAHDEVLGFIHGKQAITSLRHFMAGKSEAEIAAEFTR LEQIEATETAGITALPGAVDLLNHLNKAGIPWAIVTSGSMPVARARHQVAGLPAPEVFVTAERVKRGKPEPDAYL LGAQLLGLAPQECVVVEDAPAGVLSGLAAGCHVIAVNAPADTPRLADVDFALDSLTQLSVAKQPNGDVVVLRKT Salmonella typhi NYSGXRC-6280d SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC999 GENBANK NP_250757.1 MDGVLISSREAIAAAWSRVAGEQGVALGPDCLRDHVHGRPGGYTLDYLFGHLPMERRRILKQRVDALEEGADCPLL PGVAAVIRQLRWLDVPLALVTSSWPARIDHVLRQHDLQAAFRTLVSRDDVVHGKPAPDGYRLAAARLGVAPSRCL VFEDSLSGVQAACAAGATCVAIGEESGLLAAGARWSVRDFRELRIVREDDRLYCQHRHPATTGSERSVGVP Pseudomonas aeruginosa NYSGXRC-6280e SGX Pharmaceuticals 2004-06-30 active Selected EC999 MHSKVPPQTQIFSQEFAAFLFDMDGTLVNSIAVVERVWREWAVANGIEPNAFLQRIHGMRASEVIRREAVPGLDVD AEADMILRAEMDDVEGIIPIPGAADFLASLPAGKWAIVTSAVRELAEKRLAAAGITPPPVMICADDVVNGKPDPE GYRKAAERLGVAPESCVVFEDAPAGIQAGERMGAAVVVINVTHSHPIETPHLAIGSYGELDVVIDGNGGLKLTSS KA Agrobacterium tumefaciens NYSGXRC-6281b SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC1011 MPRRFALLCPLMLTTAIALSACRLEYNHGGNHGDTTPIATVQVIGHRGAPALRPEHTLASYQKAIDDGADIIEPDL VATQDGVLVARHENEISGTTNVADLPQFAGRRATKTIDGQSVTGWFTEDFTLAELKTLRARERIPDIRPDNTAYN DQFDIPTLSEIIALARDQSTLRGRNIGLYPETKHPTYFQSIGLPLEDRLIAALRQDDFTASRTTVHIQSFEVANL KSIRNRIGGSQPNWKLVQLLGTATQRPYDFTVANDARTYADLMTDQGLRDIAAYANGVGPDKNSVIALDANGALT DPSDLIRNAHSAGLVVHPYTFRPENIFLPAALRSGADNARNVSGSIQEIQAFLRAGVDGFFTDDPAVGRQAVDTL QR Ralstonia solanacearum NYSGXRC-6281c SGX Pharmaceuticals 2004-07-29 active Selected Cloned Expressed Soluble Purified EC1011 ICEDB: T1975 GENBANK NP_242642.1 LKRFRSFLNFKVSIVLIAIAFVLYINHTDLLFAKETKHEPLLLSHRGAHPDYVLTSDEINGCSEIQLANTEPASIE NTIPAIRAAYEAGAEIVEVDLQQTRDGNFVAFRDWNLDCRTNGTGPIWDYTTEELKQLDIGYGYQLEGDNTYPFR GDGVGLIPTLEEILNNFPEERLLLHIQSRSTSDGERLANILESLSTEQLQTLIVTGSHATITYINERFPSVQIMT KEEYQEFSTPTDRSGWSTFRSFD Bacillus halodurans NYSGXRC-6281d SGX Pharmaceuticals 2004-08-17 active Selected Cloned Expressed Soluble Purified EC1011 GENBANK NP_905473.1 MENLKNIQPREDFNWEEFEAGGVHAAVSRQEQEAAYDKTLNTIKEKEVVMGRVTAINKREVVINVGYKSEGVVPAT EFRYNPELKVGDEVEVYIENQEDKKGQLVLSHRKARAARSWERVNEALEKDEIVKGYVKCRTKGGMIVDVFGIEA FLPGSQIDVRPIRDYDAFVEKTMEFKIVKINQEYKNVVVSHKVLIEAELEQQKKEIIGKLEKGQVLEGIVKNITS YGVFIDLGGVDGLIHITDLSWGRVAHPEEIVQLDQKINVVILDFDEDRKRIALGLKQLMPHPWDALDSELKVGDK VKGKVVVMADYGAFVEIAQGVEGLIHVSEMSWTQHLRSAQDFLHVGDEVEAVILTLDREERKMSLGLKQLKPDPW ADIETRFPVGSRHHARVRNFTNFGVFVEIEEGVDGLIHISDLSWTKKIKHPSEFTEVGADIEVQVIEIDKENRRL SLGHKQLEENPWDVFETVFTVGSIHEGTVIEVMDKGAVVSLPYGVEGFATPKHMVKEDGSQAVLEEKLPFKVIEF NKDAKRIIVSHSRVFEDEQKMAQREANAERKAEAKAAQKEAAAEAANPAQAVEKATLGDLGELAALKEKLSEN Porphyromonas gingivalis NYSGXRC-6282a SGX Pharmaceuticals 2004-07-19 active Selected EC1432 MSSRKKVRVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHVIQDFRNVLNTIPNYLNTINYIIITSQRTVESL NEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNGSILADIIIDDLSTDIKACPPSELLFL VGEIRRDIIPKKLHSKGIKVREVVTYKTEELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNR LPGSIYGLRHRTYH Saccharomyces cerevisiae NYSGXRC-6282b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC1432 MKTALLLKTKSQPFDPYVEAFEKYGRDTAFIPVLRHKRVHEEQLRDKLKNVRKTYCGLIVTSQRVSETLDEALKQE DETERQKILMETPIFTVGPATDDSIRRLGFQQTHGKDCGRGEVLADLIEEWYTTTKQHKPLLFLVGEKHRDIIQR KLGDDRVDSLIVYATQELENTETQIKDTIRKHPTIDWIVAFSPTSICSLLNTFELKIATIGPTTGDYLKKLGTQP NVVSPAPNPESLASSIVAFDEENSS Schizosaccharomyces pombe NYSGXRC-6283a SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC3668 GENBANK NP_289055.1 DLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLGPDNMLSEEAMTRGLNCLSLFAERLQGFSPASVCIVGTHTL RQALNATDFLKRAEKVIPYPIEIISGNEEARLIFMGVEHTQPEKGRKLVIDIGGGSTELVIGENFEPILVESRRM GCVSFAQLYFPGGVINKENFQRARMAAAQKLETLTWQFRIQGWNVAMGASGTIKAAHEVLMEMGEKDGIITPERL EKLVKEVLRHRNFASLSLPGLSEERKTVFVPGLAILCGVFDALAIRELRLSDGALREGVLYEMEGRFRHQDVRSR TASSLANQYHIDSEQARRVLDTTMQMYEQWREQQPKLAHPQLEALLRWAAMLHEVGLNINHSGLHRHSAYILQNS DLPGFNQEQQLMMATLVRYHRKAIKLDDLPRFTLFKKKQFLPLIQLLRLGVLLNNQRQATTTPPTLTLITDDSHW TLRFPHDWFSQNALVLLDLEKEQEYWEGVAGWRLKIEEESTPEIAA Escherichia coli NYSGXRC-6283b SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC3668 GENBANK NP_230371.1 LPFTTILRMSRSRLVKQKGNKKRMTTVVSNAREIAAIDLGSNSFHMVVAKVVDQDLQLISRHKQRVRLAAGLDEQK NLDEESIQRGLECLAMFAERLQGFEPRNVRIAATHTLRQARNANLFIQRALDVLPFPIEIIPGSEEARLIYLGVA HTQPQADSMLVVDIGGGSTEMIIGKGFEAELLNSKQMGCVNFTERYFANGKLSRKNFAQAIVASEQKLESIASKY RKKGWQMAFGSSGTIKAIHEVLIGQGHEDGLITFERLSKLIEKLCEWDSIDDLQLPGLTDDRKPVFAAGVAILSA IFHGLNIKEMHFSDGALREGLLYEMEDRFKYSDIRLRTTENLAAKHLVDLEHAAKVKGHAREFLAQVANELGLPE GSELCDLLEWGALLHEVGLSINLQGFHRHSAYILRHNNMAGFNSEQQLVLSNLARFQRKSLKLNELDDFSLFKKK HIIGLIRVLRLAIVVNGQRNDDPLPPLTLSAKDDEWRLECEQPDWLENNKLLHADLQTEQEYWREVGWQLLF Vibrio cholerae NYSGXRC-6283c SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3668 MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPP SQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTG AQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQG MDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLH LAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQH AAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTL QANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH Escherichia coli O157:H7 NYSGXRC-6283d SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3668 MVNLVSSSWESVSTQPVQQHRIIAAIDMGTNSLHMVVVKIDPTLPAFSIVSREKETVRLGDRNIATGELKPEVMAK AIATLKRFQEVAKTANAETLIAVATSAVREAPNGKDFLHQIETELGLSVDLISGQEEARRIYLGVLSGMEFHNQP HLIIDIGGGSTELILGDTQEPRTLTSTKVGAVRLTSELITTDPISNIEFQYLQAYARGMLERSVEEVLANLNFGE SPRLIGTSGTIETIAMIHAREKSGTVPSTLNGYQFTLKDLREWVNRLRRMTNAERAAIPGMPEKRSEVILAGAVI LQEAMTLLGVESLTACGRALREGVIVDWMLSHGLIEDRLRFQSSIRQRSVLKQASKYQVNLEYSDRVATFALSLF DQTQGLLHHWGSNERRLLWAAAILHNCGHHVSHSSHHKHSYYLIRNSELLGYNETEIEIIANLARYHRKSPPKKK HENFRNLLSKEHRQAVSQLSALLRLAVALDRRQIGAIAQIKCDYYHHFQQFNLLIYPSRPDDNCALELWSLDYKK AVFEAEFGVKLLTHLEKNLLPNFS Nostoc sp. NYSGXRC-6283e SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3668 MPPTQLKDPVHGYIELDAALVDGLIDRKPFQRLRHVRQLSATTLVYPGANHTRFEHSLGVYHLAKTVFENLRTQPY FHQDATTTELDAIQRTLECAALLHDVGHPPFSHLGERYLDRSAILDRLADHGLHATFADAGVGNAPLREASPHEL FGCLFVCREFADAITAMDVDPHAVCAHILGYSLAYERGGRWQHGVAAQILHSPIDVDRLDYITRDNQMTGADVLS FDTARMVASYTAHPDEGLALSDKALSTIGNYLEGRIALYMWVTQHHKSVFAHALLRELLAALAAMRDTPPITIDA VLDRGIDDNTILERLRVAARDNPDSTLATLYERFRSREFPETCWKHRVAYAARVDVGDTTASASAPADDPPRATD ADIDAFSDWLTGNADRLEPRLADALGVPVHEVWIEHSYVPEYEPQALEDIPIAYGGTTRSVGDWGLYGDRAFDSP IPFVFVPHGVETQAITTLSAWFHAESTA Halobacterium sp. NRC-1 NYSGXRC-6283f SGX Pharmaceuticals 2004-10-26 active Selected Cloned Expressed Soluble Purified EC3668 ICEDB: T1976 GENBANK NP_438855.1 MNDSILEPKHRGNVREIAAIDLGSNSFHMIVARIVNGSIQVLSRLKQKVKLAEGLDENAVLNQEAITRGVNCLALF AERLQGFPMENVNVVGTYTLRRAVNNDEFLRQAAKVFPYPINIISGQTEAKTIYAGVCHTQPEKGRKLVIDIGGG STEMIIGDDFTPLMAESRHMGCVSFATQFFTDGIISPENFQRARQSAVNKIEDLGLEYRKLGWQSVLGSSGTIKT VAQVIATNLDPNGTITAERLNALIEQTLQAKHFTELNINGLNQDRVDVFVPGLAILSAVFDVFHIQQMRYSDGAL REGVIYSLEKNFQVADIRASTA Haemophilus influenzae NYSGXRC-6283g SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC3668 MDLQSMPQKPAEAFPLIAALDLGSNSFHLCLAKANIHGEVRILERLGEKVQLAAGLDEERNLSEEATQRGLDCLRR FAQFISGMPQGSVRVVATNALREARNRSDFIRRAEEVLGHPVEVISGREEARLIYLGVANSMPDSGGRRLVSDIG GGSTEFIIGQGFESELRESLQMGCVSYTQRYFRDGKITPARYAQAYTAARLELMGIENSLRRLGWQQAVGASGTI RAVALAIKAGGHGNGEISPDGLAWLKRKVLKLGDVEKLDLEGIKPDRRTIFPAGLAILEAIFDALELEQMVHSEG ALREGVLYDLVGRHQHEDVRERTISSLMQRYHVDPEQASRVEAKALKVLAEVGDAWELNGELHRDLLSWGARVHE IGLDIAHYHYHKHGAYLIEHSDLAGFSRQDQQMLSLLVRGHRRNIPADKLAEFAEEGDKLVRLCIVLRFAILFHH IRGTQEMPSVRLKAEPKSLSVTFPEGWLEANPLTQADFAQEAEWLKRVGYSLNVR Pseudomonas aeruginosa NYSGXRC-6283h SGX Pharmaceuticals 2004-07-19 active Selected EC3668 MPNTLPSYPPLKDGDLLAAIDLGSNSFHMVVARYLLGQLHVVDRLREAVRIADGLDAKGGLSSKACERALECLARF GQRLRNMPSPHVRALATNTVRRLRSPQAFLVLAETALGHSIEVVSGREEARLIYLGVAHAQPPRLDQHRLVIDIG GGSTEFIIGKGFEPLERESLQVGCIASTRRFFPEGKLSKKRWNDALTEIGTEFQQFAAQYNALGWQEALGSSGTH KTIAKICTEMKLAKGEITAEALPVLREELLKAKRIEDIHLPGLSAHRRPIIAGGILVLEAVFQTLGLEKLLVSKA AMREGILYDMLGRAGDNDPRDISVAVLMHRYAIDEQQALRVETTAQLLFQQACGPWALDADDARVLCWAARLHEL GLVIAHSHYHVHGSYVLEHSDIAGFSRQEQQVLAVLVCTHRRHVSKNAFDVLPDRLRVSVRRRAALLRLAALLHR AREPDWVPMLDLHVDGDVLMLTVPKGCLASRPLLHSDLNAEVEAMVDLGIVFKLSVV Xylella fastidiosa NYSGXRC-6283i SGX Pharmaceuticals 2004-08-10 active Selected Cloned Expressed Soluble Purified EC3668 ICEDB: T1977 GENBANK NP_274476.1 MTTTPANVLASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQKNLSAASQEQALDCLAKFGERLRGFR PEQVRAVATNTFRVAKNIADFLPKAEAALGFPIEIIAGREEARLIYTGVIHTLPPGGGKMLVIDIGGGSTEFVIG STLNPDITESLPLGCVTYSLRFFQNKITAKDFQSAISAARNEIQRISKNMRREGWDFAVGTSGSAKSIRDVLAAE MPQEADITYKGMRALAERIIEAGSVKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYDL IGRGLNEDMRGQTVAEFQHRYHVSLNQAKRTAETAQTFMDSLCHAKNVTVQELALWQQYLGRAAALHEIGLDIAH TGYHKHSAYILENADMPGFSRKEQTILAQLVIGHRGDMKKMSGIIGTNEMLWYAVLSLRLAALFCRSRQDLSFPK NMQLRTDTESCGFILRIDREWLERHPLIADALEYESVQWQKINMPFKVEAV Neisseria meningitidis NYSGXRC-6283j SGX Pharmaceuticals 2004-07-19 active Selected EC3668 MEKVHYAAIDVGSNAVRLLIKCVNSEGMEEPLSKVLIMRVPIRLGEDSFTKGYIGEEKTDNMVRLMRAYYEMMQIY RVKDYRACATSAMRDASNAEAVIAQIREKTGIHIDIIDGDEEARLVSDNHIEQIISDGGNYIYLDVGGGSTELTI PAAEIFLEVADITGAKTIIAPIVGLADGIIEDLYIRHQSQPS Porphyromonas gingivalis NYSGXRC-6283k SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC3668 MPIYDKSPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLGADNKLSEEAMERGLSCLSLFAERL QGFSPSSVCIVGTHTLRQAQNAADFLKRAEKVIPYPIEIISGNEEARLIFMGVEHTQPEKGRKLVIDIGGGSTEL VIGENFEPRLVESRRMGCVSFAQLYFPGGVINKENFQRARMAAAQKLETLTWQYRIQGWNVAMGASGTIKAAHEV LLALGEKDGFITPERLDKLKSEVLKHRSFNALSLPGLSEERKAVFVPGLAILCGVFDALAIRELRLSDGALREGV LYEMEGRFRHQDVRSRTAKSLANQYNIDREQARRVLETTMQMYEQWQAQQPKLAHPQLEALLRWAAMLHEVGLNI NHSGLHRHSAYILQHSDLPGFNQEQQMMMATLVRYHRKAIKLDDMPRFTLFKKKQYLPLIQLLRLGVLLNNQRQA TTTPPTLRLTTDDSHWTLCFPHDWFSQNALVLLDLEKEQQYWEAVTGWRLNIEEESSPEIAA Salmonella typhi NYSGXRC-6283l SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC3668 VSCITIPLRIYPYPSMSPTPRLLAAVDMGSNSFRLMIGRVDETITASGNSSSQIFQVDALREPVRLAAGLTQDKYL DQPARRRGVDALRRFGDRLRDFAPEQVRAVATNTLRVAKNAQDFLIEAEAALGFPIEVIAGREEARLIYLGASHD APACQGNRLVVDIGGGSTEFIIGNGYKPKLMESLYIGCVSHSRHFFPNGNVDDYAMKQAELAARREIQVLVQPYR TAGWKQSVGSSGTARALAELIELNGFNDKSSEHGITREGLERLKRALVKAENANRLKLSGLKPDRIPVLPGGLSI MLGVFDELDIDRMDVTDGALRLGVLYDLLGRSHHEDMRTVTIEQFMRRYSVDRAQAHRVRDAATALLSQFPDPPD ERREDNLALLGWAANLHEIGMSISHSSYHKHSAYIASHADMPGFSKTDQARLATLLLGHAGKLGKLAGGGKFLDW RMLFSLRLAFVLCRRRGVIQLPGLRVRHTEGELNEGGFEVELPKSWVEQNPLVEYSLAQEADEWERIGRRYKVVY V Ralstonia solanacearum NYSGXRC-6284a SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC3074 ICEDB: T1978 GENBANK NP_286806.1 MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLGIYADAIREQVQAMQHLRLQDDEYQWLSA LPFFKADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLE SKLVDFSALTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAH QQISPDLANSQRAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKL EIDPQSKTLVFSDNLDLRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKT ICHDKAFVRALRKAFDLPHIKKAS Escherichia coli O157:H7 NYSGXRC-6284c SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC3074 MSEPAVVSILDTDLYKLTMLQAVLEHYPDAQVSYKYTNRSPKMALNQEAYNWLREQIRGLRNLHLLPEEEQWLRKN CPYLKESFYEFMHEFEFDPENSISLNYDSETKDLSIFIHGLWKNTIFYEIPLLALVSESYFKFVDKDWSPEGQFE KAYEKGKRLIRAGCAFTDFGTRRRRDPHTQEIVLQGLMKAQEDFKGPGSFLGTSNVYFAAKYNLNVSGTVAHEWY MGIAAITQNYKQANRIASLKWVQTFGTSLLIALTDTFSTDVFLKSFTANSADDLANVFHGVRQDSGCAEEYIEKV VKHYKSIGVDPSTKVIVHSDALNVDRCIELYKYCEKCGIKSAFGIGTNLTSDFQKVSNPSEVSKPMNIVIKLFSA EGTKAVKISDDIMKNTGDRDAVIQAKHQLCLPIA Schizosaccharomyces pombe NYSGXRC-6284d SGX Pharmaceuticals 2005-02-17 active Selected Cloned Expressed Soluble Purified EC3074 ICEDB: T1980 GENBANK NP_232499.1 MNPRLFSPHIIRSLLDLDAYKINMMQAIHHFYPDVSVRYELIVRSEEDASGLLDAIRQEIAHLGTLRFSDADIHYL TQHAPHLKATFLQSLRYFHFVPQEQVEMGIVKQGGKQQLRISIRGSWRDTILYETLVMAIVSEVRSRQRWAEVPA DLPLKVLKTKLDQLKAEIERRGINNFSLTEMGTRRRFSSQVQRDVLACLKQEIPQWVLGTSNYHFAREFDLKPIG TIAHEWFMGHQALVNERDSQQVALERWLTAFDGMLAIAPTDTLTIDAFLNDFNRHLANAYDGVRHDSGCPFRWGD KMIAHYQQLGIDPTTKLFIFSDGLDFDQALELCEYFAGRVKISFGIGTFLTNDLANWRNAAGVEYRPLSIVIKLA ECQGRPVAKISDQPEKAMCEDPIFLANLKRRFNIELDVDALIQELRHQKRSPRHYISAA Vibrio cholerae NYSGXRC-6284e SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC3074 MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQE IPYLPSAYIKYISSSNYKLHPEEQISFTSEEIEGKPTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDW DYENQLEQAEKKAETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGNPDRNKSLLLGTSNILFAKKYGVKP IGTVAHEWVMGVASISEDYLHANKNAMDCWINTFGAKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPV EYTKKISHHYHDVLKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRKKSEPQVKSEPLNI VIKLLEVNGNHAIKISDNLGKNMGDPATVKRVKEELGYTERSWSGDNEAHRWT Saccharomyces cerevisiae NYSGXRC-6284f SGX Pharmaceuticals 2004-07-19 active Selected EC3074 MTTIPRAGAPLPAVPMIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNPGVDLVPYIEAIRAEIRHLCSLRF TEAELDYLRGLRFIKSDFVDFLDLFHLSEKYIDIRPAASNDGQIDIVISGPWLHTIMFEVPVLAIVNEVYFSRTQ AHPQWDEGKRRLTEKLASLTRPGLEDCRIADYGTRRRFSHTWHEHVLMEARSQLGSQYAGTSNVYFAMKHNMTPL GTMAHEYLQACQSLGPRLRDSQVFALETWAREYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEW GERMLKHYEGMRVDPQSKALIFSDSLDMPKVVRLYERFRSRCKLAFGVGTNLTNDLGYTPLQIVIKMVRCNGQPV AKLSDAPEKTMCDDPAYLAYLKQVFGVQ Ralstonia solanacearum NYSGXRC-6284g SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3074 MTDLSPLLTDLYQLTMMQGYFLSDLHRQQATFDLYFRRLPFEGGYAVWAGLEPMLDWLQGLHFAEADLDYLASLGQ FRPEFLAALREWRFSCEVTAFPEGSVVFPHEPLLTVRGPLWEAQLVETALLNTLNFQTLVATKAARCVLAAQAGG GTVLEFGARRAQGPNGAVSAARAAFVGGAVGTSNLEAGRQFGIPVSGTHAHAWVESFPTELDAFRAYAEFYPDST TLLLDTVDTLGSGLPNALTVAAELRAKGHELGGVRVDSGDLAYLSRVIRERLDAAGFPDVKIVVSNDLSESVISG VIAEGGRVDVYGVGTQLATAGGPGGGALGGVYKLAELNGRPRMKLTGDPAKSSLPGTKAVWRGLDHDHFAWDVLT LGDAPHEGLRVSDPTNPLRSARLTSRLHWRPARDLVMSGGQRTRPAEALPALQARAREELARLAPETRRLLNPHV YRVSLAPEVSELRDRLAQELRGH Deinococcus radiodurans NYSGXRC-6285a SGX Pharmaceuticals 2005-01-04 active Selected Cloned Expressed Soluble Purified EC2624 ICEDB: T1981 GENBANK NP_253367.1 MSDAISFRPMTEADLDAVLKIEYAAFSHPWTRGIFSEGLKNYHCWLMFEGSQQVGHGVIQIILDEAHLLNITVKPE SQGRGLGLRLLEHLMREAAGHQARECFLEVRASNQAAYRLYERYGFNEIGRRRDYYPAVGGREDALVMACTLFD Pseudomonas aeruginosa NYSGXRC-6285b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC2624 MTDTRKFKATDLFSFNNINLDPLTETFNISFYLSYLNKWPSLCVVQESDLSDPTLMGYIMGKSEGTGKEWHTHVTA ITVAPNSRRLGLARTMMDYLETVGNSENAFFVDLFVRASNALAIDFYKGLGYSVYRRVIGYYSNPHGKDEDSFDM RKPLSRDVNRESIRENGENFKCSPADVSF Schizosaccharomyces pombe NYSGXRC-6285c SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2624 GENBANK NP_393854.1 LSDDDVDNVIEVARDSWKWTYKDIYSDEFIENWISEKYSKEKLLNEITKSQLNLDLVFLGSFHESKLIGFIELKIS SSKAELLRLYLRPEYTHRGVGRILLSEAEELVKKRDVEECILYVHKKNYIATSFYKKNGFQVKDIYGDDLIMIKR YKV Thermoplasma acidophilum NYSGXRC-6285d SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2624 VTGPQVPLVRVLQPADGSPYFALRLALLRSDPLAYVTTAEEWAGRPLADVAGRLQPSATHVTYGVSVAGELVGMLT LLRESRAATAHRAEIVGVGVLPEFRGQGCGDALLRSALEQARRWEGVTQVELSVTDTQHAALRLYQRWGFQTWGV QPGAVRGPDGEERALHHLTLKL Deinococcus radiodurans NYSGXRC-6285e SGX Pharmaceuticals 2004-07-19 active Selected EC2624 MFDDYLSWKPYFEIVPMQHEDCAAVADLHALRFPRPWNDGEFSGLLTQGSVFGAVARQTNAFFSKPLGGFVLAREV AGEAEILTVAVSDKFSRAGLGWRLMQSAIREAMMRGAETMFLEVDNNNASALGLYKKLGFKTVAERKAYYTAKNG SKSTALVMRRDLR Agrobacterium tumefaciens NYSGXRC-6285f SGX Pharmaceuticals 2004-08-11 active Selected Cloned Expressed Soluble Purified EC2624 ICEDB: T1982 GENBANK NP_207727.1 MTIKVFSPKYPTELEEFYAERIADNPLGFIQRLDLLPSISGFVQKLREHGGEFFEMREGNKLIGICGLNPINQTEA ELCKFHINSAYQSQGLGQKLYESVEKYAFIKGYTKISLHVSKSQIKACNLYQKLGFVHIKEEDCVVELGEETLIF PTLFMEKILS Helicobacter pylori NYSGXRC-6285g SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2624 VNIRRAVCADCEELAALDAVCNPSAWTQRQFESALVSPSEQVFLAEKDGGIAAFIVWQNLPDESELHLIATAPECR RQGIASALLEYWFTHLPEDTQRLLLEVRAGNTAAQALYTAHGFSITGRRKNYYRTADGKTEDAVLMEKIC Neisseria meningitidis NYSGXRC-6286a SGX Pharmaceuticals 2004-07-19 active Selected EC2225 MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEI LMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFY QYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGD KINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGAR IIGGCCRTSPKDIQEISAAVKKYT Saccharomyces cerevisiae NYSGXRC-6287a SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC2481 VFTPRGFKFAGVHCKIKRKRKDLGIIFSEVPCVAAGVFTTNVVKAAPVIYDMEILKKNPNGIKAVVVNSGVANACT GEQGMINARRMAEKTAEELGVPVESVLVSSTGVIGVQLPMDKVENGIEEAARVLSNDPLPFAEAIMTTDTKVKMH STKVMIDGKEITVLGIAKGSGMIHPNMATMLSFITTDAKISEEALKKLLKLSVDDSYNMIDVDGDTSTNDMVIVL ANGLAGNTTIQPETDGFWKLYEAVHEVNQVLAEKIVEDGEGATKVMEVHVINAPDIKSARLIARSIVSSNLVKTA IYGEDANWGRVIAAAGYSGATFDPEKLDLFFESEAGRIKVAENGQGVSFDEEEAKKILSEKKIRIILDMKQGKET AKAWGCDLTEKYVEINGRYRT Thermotoga maritima NYSGXRC-6287b SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2481 MNVINETANVLKLETGSVTSAKGFSAVGIHTGVKRKRKDLGAIVCEVPASSAAVYTLNKVQAAPLKVTQESIAVEG KLQAMIVNSGIANACTGKRGLDDAYTMRAVGAETFHIPEHYVAVTSTGVIGEFLPMDVITNGIRQLKPEATIEGA HAFNEAILTTDTVEKHTCYQTIVNGKTVTVGGVAKGSGMIHPNMATMLSFVTTDANIDHGHLQGALSAITNETFN RITVDGDTSTNDMVVVMASGLAENEALTPEHPDWANFYKALQLACEDLAKQIARDGEGATKLIEVEVTGAANDQE AGMVAKQIVGSDLVKTAIYGADANWGRIICAIGYSGCEVNQETIDIAIGPIVTLKQSEPTGFSEEEATAYLKEAD PVKISVNLHIGNGTGKAWGCDLTYDYVRINAGYRT Bacillus halodurans NYSGXRC-6288a SGX Pharmaceuticals 2004-01-22 active Selected EC2604 VRKIRNLLLTLYFYFIATVYIVFYGGFVLFRSFLMRDREKARKYVLKEIEKFGKRAFTWLFSDVVVEGSENIPKDR NFIVVANHQSLMDIPLILGFVATGAFIAKEELRKIPGVNWYIRYLNGVFLDRKNPRRAVRALREAIEKLKNGVTF IVFPEGTRSPDGKVLSFKKDSLMIAVKTGVPVLPVSIWGTYHLIPKGRWTFTPGKVFLKIHEPVDPKGFSSEEEL RKYVEEVVKRGVEELKARWSK Thermotoga maritima NYSGXRC-6288b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed EC2604 GENBANK NP_290026.1 MSKLMSRLEWTWRLVMTGLCFALFGLGGLLLSVVWFNILLVLVWDTSRRRRLARRSIAASFRLFLTVAKGLGVLDY RIDGAEILHQERGCLVVANHPTLIDYVLLASVMPETDCLVKSALLKNPFLGGVVRATDYLINSEAETLLPRCQQR LAQGDTILIFPEGTRTKPGEKMTLQRGAANIAVRCASDLRIVTIGCSEHLLDKQSKWYDVPPDRPFFTVAVHGRV EINKFYDATSQEPALAARQLNRHLLLQLQQGCLPLSGINNASALSGN Escherichia coli O157:H7 NYSGXRC-6288c SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2604 MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVDVITLGVGILPYQIHYMAKKELFQNKWIGSFLK KIHAFPVDRENPGPSSIKTPIKLLKEGEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELF KKGKMKLIIGEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL Bacillus subtilis NYSGXRC-6288d SGX Pharmaceuticals 2004-11-19 active Selected Cloned Expressed Soluble EC2604 GENBANK NP_816325.1 MFFTFMRGVVRVILFVINGNAHYENKEKLPKDQNYVLVAPHRTWWEPLYLAVAGSPKKFSFMAKKELFKNPVLRFI LKHANAFPVDREKPGPSAIKTPVKILKNSDLSLIMFPSGTRHSSELKGGVALIAKMGRVPIVPSVYQGPLTLKEL FKRKKVTVRFGEPIDISDIKKMDKDGLAEVERRMQEAFDQLDKEIDPTFKYESTEKE Enterococcus faecalis NYSGXRC-6288e SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC2604 LIRYNNNKKTIEGDRMFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRTWWDPVYMAFATKPKQFI FMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINVLKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKV RIMPVTYTGPMTLKGLISRERVDMNFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWW FIRIPALILAIILAILTIIFSFIASFIWNPDKKREELA Streptococcus pneumoniae NYSGXRC-6288f SGX Pharmaceuticals 2004-01-22 active Selected EC2604 MSTVQAIRTVLFYLLLSASAFVWGTLSFFIAPILPFRARYRFVVQNWCRFAIWLTRVVAGIRYEVRGLENIPEKPC VILSKHQSTWETFFLSGFFEPLSQVLKRELLYVPFFGWALALLKPIAIDRSQPKLALKQLAKQGDECLKKGAWVL IFPEGTRIPVGQMGKFSRGGTALAVNAGLPVLPIAHNAGQYWPKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAEL NQRAEAWVSETMAEISPIQQRVSHPEPSVVS Pseudomonas aeruginosa NYSGXRC-6288g SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed EC2604 GENBANK NP_357003.2 LMLKLRSFLFNTLFYLNLIVRMIVLTPIYFILPRKIAYEIPKNWARSNHWLMKTIVGTTFEIEGLENIPETGCIFA PKHQSFWDTYALLPNLPDPVYILKRELLWIPLFGWYAMKQRMIPVNRAARGKVMLKVMERAKEEMAAGRELIIYP EGTRRPPGAEPEYRYGIARLYRDLQVPVIPVAMHPGLFWPRRSTMRYPGHFKVRILPAIEPGLDPDVFFKRLIEV TEKASDELLLETARNNPHLPLPPTAVKRIAELQGKETTAD Agrobacterium tumefaciens NYSGXRC-6288h SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2604 MRWIFLYIYFVFYMIRTTFFKIKLSYIRRNAPEQEYEAAVHKVIFNWAKTMLRVIGVKVNVKGMENIPKDTCVFIS NHQSNVDFLAIMGTIDKQIGFIAKKEILKIKIVSSWMKMMHCVFIDRNDIRKSLMAINEGVDNLKKGYSMAIFPE GTRSKSSNMGEFKKGSLKLATKANAVVVPIAIDGGYRLFEDVKGKLRPGVVNMSILEPLNIADLDKEQKMNLSDI LHKKISEELKLIKQD Clostridium acetobutylicum NYSGXRC-6289a SGX Pharmaceuticals 2005-02-17 active Selected Cloned Expressed Soluble Purified EC2628 ICEDB: T1983 GENBANK NP_372574.1 LDQQSKEQLNIREMTKEDVPQVFDLERRSFNDSSWTIDAFYHEIEQNNFAKYFVLEFEQQIIGYLGLWIVIDQAQI TTVAIDDNYRGYGLGQMLLKYGINYASHTCDVMSLEVRVNNKVAQHVYENLGFQYGGKRKNYYGEGEDAMVMWVN LND Staphylococcus aureus NYSGXRC-6289b SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC2628 GENBANK NP_248538.1 MIIRKFSSKDLDAVEEIEREAFKTPYPTSLILGFWSMYPNCFYVAEIDGRVVGYILGSMDWGNGHIISLAVKKECR GLGIGTALLKTLENYYFNIANCNYIVLEVRVSNVLARRFYYRMGYRDRKLLPKYYEDGEDAILMIKKKPNAKGPL IITLW Methanococcus jannaschii NYSGXRC-6289c SGX Pharmaceuticals 2004-06-30 active Selected EC2628 VISSKLKLQSLTSKDLSAILELDQACFGGLWTMEGYQRELDSPNSDLLGLFSPTSSIKLLGMGCFWSIVGEAHITI LAVHPQYHRQALGQALLYFLLRTASDRGLERATLEVRASNLAAISLYQKFGFQTAGRRRAYYQDNGEDALILWLP DLQYPQFQKTLAHWETIIRDDLQKYSWSLVS Nostoc sp. NYSGXRC-6289d SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC2628 GENBANK NP_111735.1 MIVRRYLKQDLCAVARLEVRSFEIGPYDKEYLREVLENASSISYIAQISDKIVGYIVAMPLNSQEIDIESIATDPD FRKRSIGTRLIARIENESKSLGYRNIILEVRKENIEAISFYSRLGFNIKEFIVNYYEEYYRGSRDAYRMVKSLS Thermoplasma volcanium NYSGXRC-6289e SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC2628 GENBANK NP_341652.1 MVIITDATEADLDQIFQIETESFEDPYPYSLLRAYLFLANKLYLVAKQREKVVGYIIGIIQYGYRGHIVSIAVEPI YRKQGIGAKLLNEIEERFKLNGARYSYLEVNTNNLSAISFYRANGYLIMYVRKNYYGRDKHAFVMVKNLYYKYLD Sulfolobus solfataricus NYSGXRC-6289f SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC2628 ICEDB: T1984 GENBANK NP_148282.1 MNREAQGSQEGVRIRKARAQDIPIVMEINLESLPENYWYGFYKYILDNWGEAFLVAEVGGEIVGYAMSRVEQTSDP VLLGMKDELEGDKSVIDKILDAIRNQLSEERPVGHLVSIAVRPGFRGRGIGSKLLSATVRVMKNVYRVDAIFLEV RVSNMPAIRLYEKFGFRKVRRIKGYYRDGEDAFVMVKRLL Aeropyrum pernix NYSGXRC-6289g SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble Purified EC2628 ICEDB: T2172 GENBANK NP_816121.1 MWKNFNFVTKYFTKRRQRYITKTIAMNQQEFQLREITYQDIKDLLAIEREVYAGELPWTMSAFMAELGSKAPHLYL LAAINGKTVGFIGCRIQGTDAHITNVAVHTAYQGLGLGRSLIEETRIFAKKNRCETLSLEVRMSNVKAQRLYRKI GFVSQTVKKGYYDENNEDALEMIIDLKEE Enterococcus faecalis NYSGXRC-6290a SGX Pharmaceuticals 2004-01-22 active Selected EC3449 MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMAT AQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAI PTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVH TGVTKREHMTDDMEKPTHAIDSLTEWIPYI Bacillus subtilis NYSGXRC-6290b SGX Pharmaceuticals 2004-07-19 active Selected EC3449 MTAQQGVPIKITNKEIAQEFLDKYDTFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKK FASFGIDVKEEQIFTSGYASAVYIRDFLKLQPGKDKVWVFGESGIGEELKLMGYESLGGADSRLDTPFDAAKSPF LVNGLDKDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDSTFPQKGYTFPGAGSMIESLAFSSNRRPSY CGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGGTLLVLSGIETEERALKISHDYPRPKFYIDKL GDIYTLTNNEL Saccharomyces cerevisiae NYSGXRC-6290c SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3449 VAAWTLNPAAQGSAMRPGRIDAPFLDRYRRAMMDFPPGLSALSDRYDVVLSDVWGVIHNGVASFPEACEALTKWAQ TKGPVVLISNSPRPSHDVVAQLDALGVPRSAWQGFVTSGDATRALLKANAPGKVWKIGPARDEVLYEGIDLVAAG CEDAGFISCTGLYEDEVEVPEDYRDRLKVAAERGLLFICANPDRVVQRGDRLIYCAGALADLYESLGGKVVMAGK PFGQIYDLAVAEAARLLGRPVDRARILCVGDGVITDVKGAHDQKLACLFVAKGIHGDKAVGPDGQLVPDAVHALL DAEAVGATHAIGDLVW Caulobacter crescentus NYSGXRC-6290d SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC3449 VRLADIRHWVFDMDGTLTRAVHDFPAIRRALDIPEQDDILLHLAALPEAEAAAKHAWLLEHERALAEAARPAPGAL ELVRELQRRGVRLGILTRNDHQLALITLEAIGLGGCFPSEHILGRGEARPKPDPDGLLRIARRWNVTPAELVMVG DYRFDLDCGRAAGSRTVLVNLPENPWPELADWHAADCHALLEQLQTP Pseudomonas aeruginosa NYSGXRC-6291a SGX Pharmaceuticals 2004-08-02 active Selected Cloned Expressed EC4293 GENBANK NP_011778.1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNE SRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFE EVYREQGAKGAKKLKEVTKRFEEVRLRGRKRSMLG Saccharomyces cerevisiae NYSGXRC-6291b SGX Pharmaceuticals 2004-08-18 active Selected Cloned Expressed Soluble EC4293 GENBANK NP_438429.1 MHQFQQDNQYFIFNFDRTFEQATEFFQAEFWQKQERVIGSAKGRGITYFLQTEDWFGVNCALRHYYRGGLWGKLNK DRYRFSALETTRSFAEFHLLQRLYEAGLPVPKPIAARIQKGKLGICYQADILTEKIENAQDLTALLQTQTLPKET WMQIGRLIRKLHDLQICHTDLNAHNILLQQTEQGQKCWLLDFDKCGEKSADFWKVQNLNRLKRSFEKEVGRMNIQ FTEQNWADLTSAYHQ Haemophilus influenzae NYSGXRC-6291c SGX Pharmaceuticals 2004-07-26 active Selected Cloned Expressed Soluble EC4293 GENBANK NP_147735.2 VEDRRGGHTMVSLAPWGPAARLEELPLLKRGAEAEIRLGEFMGLQAVYKARVRKPYMHPRLAERLVRLRTRREARV IAAARAAGVSAPALLAVFPSLGLIVMEYVEGPLLKDVIDRRGLGAGGLVEEAGYNLGLLHRAGVVHGDPTTSNYI VRGGGVVLIDYGLAEFSSSVEDRAVDLHLFRRAVESTHAPLAGELYSLYTRGYLRAVGEWGGEVLRRAEEIRLRG RYVRERRRSVWGVG Aeropyrum pernix NYSGXRC-6291d SGX Pharmaceuticals 2004-08-13 active Selected Cloned Expressed Soluble Purified EC4293 GENBANK NP_229884.1 MQSKTAKLPDNDRNRPLIQTFNDAQQKVWFDDALLHEDPSQCCNPEFWQQNGKVLGSATGRGTTWFVQLQQTQGAL RHYRRGGLFGKLVADSYWFTGWEKTRSYQEFMLLNHLRDAGVNVPRPIAARVQKHGLLYKADLLSEKVPNARDLV SILQESPISDELYRKIGREIRKMHDAQVNHTDLNIHNILIDDQEKVWIIDFDKCYVQIGDSWKQGNLKRLKRSFE KEVCKRGINWSLEAFAIISSYKHEE Vibrio cholerae NYSGXRC-6291e SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC4293 MREAIPAVIETVLGAADGDIDAVAFSRGPGLGPCLRIVGSAARALAQALDVPLVGVNHMVAHLEIGRHQSGFQQPV CLNASGANAHVLAYRNGRYRVLGETMDTGVGNAIDKFTRHVGWQHPGGPKVETHARDGEYTALPYVVKGMDFSFS GIMSAAKDAVDDGVPVADVCRGLEETMFAMLTEVAERALALTGRDELVLGGGVGQNDRLRGMLEAMCAARGASFH APEPRFLRDNAGMIAVLGAKMAAAGATIPVADSAINSQFRPDEVSVTWRDPESPARDPGADAVRQGAEATVTFAD DAVIKERAPKAYRHDRLDDRLRRDRTVLEARLTSDARRQGVPTPLVRDVDVPAATITLQHVGDADLRDALSPARV RAVGRHLATIHDGGFVHGDPTTRNVRVGAERTFLIDFGLGYYTDAVEDYAMDCHVFEQSLVGTAADADALVAAFE DAYEEAAASGRVLDQLRAVEGRGRYQDDPETA Halobacterium sp. NRC-1 NYSGXRC-6291f SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC4293 MSEKPDLRQRCSDIYREIKEKKLTVVKQGAEAITIKTEFYPGEVCLLKCRPAKRWRHPILDQKLSRKRCLVEARLL AKCHYVGIKCPMLYFIDANRGQIYMEWIDGPCVRDYIREICECEIEKKLIPLMKRIGSEVAKMHKNDIVHGDLTT SNMMLESHNNPVPIFIDFGLGSVSESEEDKAVDIYVLERALSSTLPESESLFHHVLDSYAQSWKQSKATLRRFEE VRMRGRKRTMIG Schizosaccharomyces pombe NYSGXRC-6292a SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC4940 MGLLALGTPLQWFESRTYNEHIRDEGIEQLLYIFQAAGKRDNDPLFWGDELEYMVVDFDDKERNSMLDVCHDKILT ELNMEDSSLCEANDVSFHPEYGRYMLEATPASPYLNYVGSYVEVNMQKRRAIAEYKLSEYARQDSKNNLHVGSRS VPLTLTVFPRMGCPDFINIKDPWNHKNAASRSLFLPDEVINRHVRFPNLTASIRTRRGEKVCMNVPMYKDIATPE TDDSIYDRDWFLPEDKEAKLASKPGFIYMDSMGFGMGCSCLQVTFQAPNINKARYLYDALVNFAPIMLAFSARAP AFKGWLADQDVRWNVISGAVDDRTPKERGVAPLLPKYNKNGFGGIAKDVQDKVLEIPKSRYSSVDLFLGGSKFFN RTYNDTNVPINEKVLGRLLENDKAPLDYDLAKHFAHLYIRDPVSTFEELLNQDNKTSSNHFENIQSTNWQTLRFK PPTQQATPDKKDSPGWRVEFRPFEVQLLDFENAAYSVLIYVIVDSILTFSDNINAYIHMSKVWENMKIAHHRDAM VFEKFHWKKSFRNDTVVETEDYSMSEIFHNPENGIFPQFVTPILCQKGFVTKDWKELKHSSKHERLYYYLKLISD RASGELPTTAKFFRNFVLQHPDYKHDSKISKSINYDLLSTCDRLTHLDDSKGELTSFLGAEIAEYVKKNKPSIES KC Saccharomyces cerevisiae NYSGXRC-6292b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC4940 MGLLVLGTPLDWPESKKYCDYVRENGIMQFLHMYDTYISKKQDVLLWGDEIECIVVSMDDKSKKARVSLRQEDILN ALGKYEETFRHVDFGPVYAALRNETCPKKIDAILSEVAKNPADYVERIGGNSNKDTIEITSSTKPHAQNAVPTFH PEYGRYMLESTPGAPYGSTLKDFTFVEYNMRLRRKIIENHLLPNELPLTITNFFRLGTPGFTDPEVEANGAISRS FFLPDDVINTHVRFPTLTANIRQRRGRKVAMNVPIFFDKNTIKPFHDPTVPWDRNLFPEDANARDGAALDNHIYM DSMGFGMGCCCLQITFQAKSCDEARLLYDQLTPITPLMLALSAGTPAFRGYLADQDCRWNVIAGAVDDRTEEEMK TVPKSRYDSVDLYISNDKRNLPEYNDVPVVINQDCYDKLIKDCIDERLAKHMAHIFSRDPLVIFSDSILQDNSVS NAHFENLNSTNWQSMRFKPPPPGSDIGWRVEFRSMEIQITDFENAAYSIFVVMLSRAILSFNLNLYMPISLVDEN MKAAHARDAIHRKKFWFRCNPFPDASTDDESGQFRQLTIDELFNGEHRENGFPGLITIVRSYLYSCNPDAKTICL IERYIRLISQRANGQCLTAASWIRNFITTHPSYKQDSVVNDEINYDLIRRIAKIVDGDYDDTLLGKCS Schizosaccharomyces pombe NYSGXRC-6293a SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed EC1170 GENBANK NP_216805.1 VPKSRRAVSLSVLIGAVIAALAGALIAVTVPARPNRPEADREALWKIVHDRCEFGYRRTGAYAPCTFVDEQSGTAL YKADFDPYQFLLIPLARITGIEDPALRESAGRNYLYDAWAARFLVTARLNNSLPESDVVLTINPKNARTQDQLHI HISCSSPTTSAALRNVDTSEYVGWKQLPIDLGGRRFQGLAVDTKAFESRNLFRDIYLKVTADGKKMENASIAVAN VAQDQFLLLLAEGTEDQPVAAETLQDHDCSITKS Mycobacterium tuberculosis NYSGXRC-6293b SGX Pharmaceuticals 2004-11-30 active Selected Cloned Expressed Soluble EC1170 GENBANK NP_838959.1 LMKSSAAGRKRKKSILLTAVRSIRSANADFPRIIIKPGGFSRPGFLFVTILRYPCISLRYREKKMKKAGLLFLVMI VIAVVAAGIGYWKLTGEESDTLRKIVLEECLPNQQQNQNPSPCAEVKPNAGYVVLKDLNGPLQYLLMPTYRINGT ESPLLTDPSTPNFFWLAWQARDFMSKKYGQPVPDRAVSLAINSRTGHTQNHFHIHISCIRPDVREQLDKNLANIS SRWLPLPGGLRGHEYLARRVTESELVQRSPFMMLAEEVPEAREHMGSYGLAMVRQSDNSFVLLATQRNLLTLNRA SAEEIQDHECEILR Shigella flexneri NYSGXRC-6294a SGX Pharmaceuticals 2004-07-19 active Selected EC2654 MQPVLFRTLSLGVAIAAASSSAFAATLDGGAVAAPDEYGAKVAAQILKAGGNAVDAAVATAFTLAVTYPEAGNIGG GGFMTLYMDGKPYFLDYREVAPKAASKTMYLDDKGEVIENLSLVGAKAAGVPGTVMGLWEAHKRFGKLPWSELLT PAIGYAQKGFKVADKQFQYRQDAVALFNGKTNFGDYFGHMKAGEAFLQPDLAKTLERIADKGPDEFYKGHTADLL VAQMQQDKGLITHQDLADYKVRWREPMRVDWQGNTLYTAPLPSSGGIALAQLLGIKENRAADFKGVELNSARYIH LLAEIEKRVFADRADYLGDPDFSKVPVARLTDPAYLKQRAAEVNPTAISPTEKVRPGLEPHQTTHFSIVDADGNA VSNTYTLNWDFGSGVVVKGAGFLLNDEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPSIVTRDGKVSLV VGTPGGSRIFTSIFQVLNNIYDFHLPLEKAVAAQRVHHQLLPKDTIYYDAYAPLAGKVAEELKAMGYTLEDQGWN MGDIQAIRVDGKALETASDPRGRGVGLVVKP Pseudomonas aeruginosa NYSGXRC-6294b SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2654 LPAPPNRLAWRNDLLEAALRLFAPLAAALSAALLLVAPSVEAKPRSAAAAVRALEAGAVASPDQYGALAAQEVLKA GGNAVDAAVATGFALAVTYPEAGNLGGGGFMTVYMDGKPYFLDYRETAPAAARADMYLGPDGELVEGLSLYGGLA AGVPGTVRGLAMAHQRFGKLPWGQVLAPAIRYARDGFVVDAHLAGVLADEPPPEFAKTNFRTYFAAHKAGTLFKQ PELAATLERIALVGDRAFYEGKTADLIVAQMARGPVKGLITKADLSTYKAAWRTPLVAKWRGYDVITAPPPSSGG IALMQLLLMKQNLAPMFQGVALNDPQYVHLLAEIEKRVYADRAEYLGDPDFVKVPVSNLIDPAYVARRAKEVDPA KPSATKAVQPGLEKHETTHYSIVDQWGNAVSNTYTLNGSFGSGVVVEGAGFILNNEMDDFSAKPGAPNMFGVVGG AANAIAPGKRPLSSMTPTILTKDGRVAMVIGTPGGSRIFAWVFQVLANVYDHGLSLKAAQAAPRFHHQLLPQNVI FYERSGPPSADLKAALEARGYTWTESFSGDVEAIQVLGRTPVPEPDPRARGVGLVVK Caulobacter crescentus NYSGXRC-6295a SGX Pharmaceuticals 2004-01-22 active Selected EC4977 MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKITMLKLDPYINVDPGTMSPFQHGEVFVTQDGAETDLDLGHYE RFVRTTMTQNNNFTTGRVYMDVLRKERRGDYLGATVQVIPHITDEIKRRIIKGAGDADVALVEIGGTVGDIESQP FLEAIRQLRVEIGAKRAMLMHLTLVPYIATAGETKTKPTQHSVKELRSIGLQPDVLVCRSDHPIDVSSRRKIALF TNVEERAVIALEDVDTIYRIPSVLHAQGLDDIVVERFGLECGQADLSEWDRVVDAKLNPEREVTIAMVGKYMELL DAYKSLIEAMTHAGIQSRTKVNLRYIDSEDIEQQGTSLLEGVDAILVPGGFGLRGVEGKISTVQYARENKIPYLG ICLGMQVAVIEYARNVLGWSDANSTEFDKSSGHPVVGLITEWQDATGATEIRTEASDLGGTMRLGAQECQLQTGT LVHDCYAKDVIVERHRHRYEVNNNLLPQLEQAGLKISGRSGDGALVEVVEAPEHPWFVACQFHPEFTSTPRDGHP LFSGFVNAALKYSGKA Pseudomonas aeruginosa NYSGXRC-6295b SGX Pharmaceuticals 2004-01-22 active Selected EC4977 VPNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEVFVTEDGAETDLDLGHY ERFMDVNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVTDQIKDMIRYASKINNAEITLVEIGGTVGDIE SLPFLEAVRQLKLEEGEDNVIFVHIALVEYLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKI ALFTNVKVDHIVSSYDVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVGK YTKLKDSYISIKEAIYHASAYIGVRPKLIWIESTDLESDTKNLNEILGNVNGIIVLPGFGSRGAEGKIKAIKYAR EHNIPFLGICFGFQLSIVEFARDVLGLSEANSTEINPNTKDPVITLLDEQKNVTQLGGTMRLGAQKIILKEGTIA YQLYGKKVVYERHRHRYEVNPKYVDILEDAGLVVSGISENGLVEIIELPSNKFFVATQAHPEFKSRPTNPSPIYL GFIRAVASL Sulfolobus solfataricus NYSGXRC-6295c SGX Pharmaceuticals 2004-01-22 active Selected EC4977 VRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETD LDVGHYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVIT EIGGTVGDIESQPFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDR DVPEALKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHET VRIALVGKYVELSDAYLSVAEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHGVLIPGGFGIRGIEGKI GAIAYARARGLPVLGLCLGLQCIVIEAARSVGLTNANSAEFDPDTPDPVIATMPDQEEIVAGEADLGGTMRLGSY PAVLEPDSVVAQAYQTTQVSERHRHRYEVNNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPE LKSRPTRPHPLFVAFVGAAIDYKAGELLPVEIPEIPEHTPNGSSHRDGVGQPLPEPASRG Mycobacterium tuberculosis NYSGXRC-6295d SGX Pharmaceuticals 2004-01-22 active Selected EC4977 MKFKLSKKQKVLNSPIHLSTMTKFIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQH GEVFVLDDGGEVDLDLGNYERFLDTNLTFEHNITTGKVYSTVIEKERRGEYLGATVQVIPHITDEIKRRIREIAK DYDIVVVEIGGTVGDIESMPFLEAARQMQLEEGRENVAFVHVTYVPKLKVVGEQKTKPTQHSVKELRSLGIQPDA IVARSEDPLEEEARKKISLFTNVPREAVVSAYDVEDTYEVPLLLEREGLGKYLIKRLKLEDREPDLREWEKMVAK YKALKETVEIAIVGKYVKLTDSYLSIKEALKHASVSNDVKVKIRWIEAEDIEEHGTKLLEGVDGIIVPGGFGARG AEGKIMTIKYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHSTEIDPQTPYPVVDLMPEQRNLEKLGGTMRLG AYPVKIKKGTLAYRLYKKELVYERHRHRWEVNPDYIEAFEKAGLVFSGVAGDDERRMEILELPDKRYFIATQFHP EFKSRPMRPAPVFHGLVRAAKEYKQEKNATN Pyrococcus horikoshii NYSGXRC-6295e SGX Pharmaceuticals 2004-01-22 active Selected EC4977 MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYE RFIDSTMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITDEIKRRIHEGAAGYDVAIVEIGGTVGDIESLP FLEAIRQMRSQLGRNNTLFAHLSYVPYIAAAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALF CNVEERAIVGSYDVDSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDLT ESYKSLIEALKHAGIHTETDVQITFVDSENIEKNKGDVSMLKDMDAILVPGGFGSRGVEGKIAAVRYARENNVPY LGICLGMQIALIEYARDVAGLKGANSTEFDLKCAAPVVALIDEWQTADGSVETRDESTDLGGTMRLGAQEVELKA GSLAAKIYGSGHIRERHRHRYEVNNNYVPTLEQAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRK GHPLFTAFVKAALNNKKA Neisseria meningitidis NYSGXRC-6295f SGX Pharmaceuticals 2004-01-22 active Selected EC4977 MSPRKYVIVTGGVLSSVGKGLTTASLALLLSSRGYSVEAIKIDPYINVDAGTMNPYMHGEVFVTEDGGETDLDIGH YERFLGKNLSRKHNITTGQIYFSVISKERSGDYLGQTVQVIPHITDEIKSRIKEVGDVSGADVVIVEIGGTVGDI EGLPFLEAARQMRLEEGFDNTFFIHVALSPYLPTTGEQKTKPVQHSIQELRRIGIQPDAVVVRSHQPLEQEGLRK IALYATLPMENVINSYDIENIYRLPLLLEKQGLARLVERRLFGRETRPDLSRWEEFVALYEKASRRVKVAMVGKY TKLRDSYISIVEALKHASAYEGVRPELLWVESTDIERGVVDVDRVFEEADGAIVLPGFGVRGVEGKIEAIRRFRE GKKPMLGICFGMQLSVVEYARNVLGLKEAHTTEVNPETPHPVVDLLPEQRGIDKLGGTMRLGARPVRIVEGTILW SLYGRELASERHRHRYEVNPTYVDRLVEAGLVVSAWSQEGYVEAVELRPRDHPFFLATQFHPEFKSRPLNPAPVF KGFVTAVARLRG Aeropyrum pernix NYSGXRC-6296a SGX Pharmaceuticals 2004-01-22 active Selected EC4919 MVKVLILGQGYVASTFVAGLEKLRKGEIEPYGVPLARELPIGFEDIKIVGSYDVDRAKIGKKLSEVVKQYWNDVDS LTSDPEIRKGVHLGSVRNLPIEAEGLEDSMTLKEAVDTLVKEWTELDPDVIVNTCTTEAFVPFGNKEDLLKAIEN NDKERLTATQVYAYAAALYANKRGGAAFVNVIPTFIANDPAFVELAKENNLVVFGDDGATGATPFTADVLSHLAQ RNRYVKDVAQFNIGGNMDFLALTDDGKNKSKEFTKSSIVKDILGYDAPHYIKPTGYLEPLGDKKFIAIHIEYVSF NGATDELMINGRINDSPALGGLLVDLVRLGKIALDRKEFGTVYPVNAFYMKNPGPAEEKNIPRIIAYEKMRIWAG LKPKWL Thermotoga maritima NYSGXRC-6296b SGX Pharmaceuticals 2004-01-22 active Selected EC4919 MVRVAIIGQGYVASIFAVGLERIKEGELGYYGIPLANELPIKVEDIKIVASYDVDKTKIGLPLSEIVQRYWKGNVP ESLQEVFVRKGIHLGSLRNLPIEATGLEDEMTLKEAIERLVEEWKEKKVDVIINVPTTEAFTPFGKLEELEKAIK DNNKERLTATQAYAYAAAQYAKEVGGAAFVNAIPTLIANDPAFVELAKESNLVIFGDDGATGATPLTADILGHLA QRNRHVLDIVQFNIGGNTDFLALTDKERNKSKEYTKSSVVEDILGYDAPHFIKPTGYLEPLGDKKFIAMHIEYIS FNGARDELIIAGRINDSPALAGLLVDLARLGKIAVDKKEFGTVYPVNAFYMKNPGPKEAKNIPRIIAYEKLRQWA GLPPRYL Pyrococcus furiosus NYSGXRC-6297a SGX Pharmaceuticals 2004-11-29 active Selected Cloned EC1798 MRDKVTGARRWVVKIGSALLTADGRGLDRNAMAVWVEQMVALHCAGIELVLVSSGAVAAGMSRLGWVSRPSAMHEL QAAASVGQMGLVQAWESSFALHGLQTAQVLLTHDDLSDRKRYLNARSTLRTLVELGVVPVINENDTVVTDEIRFG DNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPDAQLIYEARADDPQLDAVAGGSAGALGRGGMQTKLRAAR LAARSGGHTVIVGGRIERVLDRLRAGERLGTLLTPDRSRKAARKQWLAGHLQMRGTLVLDDGAVKAVSQDHKSLL PVGVKAVQGSFRRGEMVVCVDQGGREVARGLVNYSALEAQKILGQPTDAIEALLGYVDGPELVHRDNLVLV Pseudomonas aeruginosa NYSGXRC-6297b SGX Pharmaceuticals 2006-09-29 completed Selected Cloned Expressed Soluble Purified Crystallized Diffraction Native diffraction-data Phasing diffraction-data In PDB EC1798 ICEDB: T1985 PDB 2IJ9 GENBANK NP_070866.1 PFAM PF00696 MKVVLSLGGSVLSNESEKIREFAKTIESVAQQNQVFVVVGGGKLAREYIKRARELGASETFCDYIGIAATRLNAML LISAIPSAAKKVPVDFMEAEELSKLYRVVVMGGTFPGHTTDATAALLAEFIKADVFINATNVDGVYSADPKSDTS AVKYDRLSPQQLVEIVSRSSAKAGTNVVIDLLAAKIIERSKIKTYVILGTPENIMKAVKGEAVGTVIA Archaeoglobus fulgidus NYSGXRC-6297c SGX Pharmaceuticals 2004-07-19 active Selected EC1798 MTGTPPPSRFPEQPIPPWRRAVLKVGSSLLAAAGGGLSPRFALDLAHFVSANITAGRQLVIVSSGAVAAGRALIPP LPESGGALAARQALAALGQAQLIALWQRFFDRPVAQVLLTHDDLRNRRRYLNARATLRELLHLGTLPVVNENDTV SVDELKLGDNDNLAAIVAALIDAQALFIATDIDGLYTTDPRHHPDAQPLHEVRTLTPEHLAMAGDSSSTVGTGGM RTKLEAALKAGAAGIDTYLFNGRSSDVVRGLAQHRLRGTRIHPTCTPIAARKYWLRHAPVEPGAILIDAGAAAAL AQQGASLLPGGVLSAEGDFRRGDMIQIATRSPDHPPHPLARGLVQYSAADVRRIAGCHSRDIQPLLGYTYGDTIV HRDDLVLL Xylella fastidiosa NYSGXRC-6297d SGX Pharmaceuticals 2004-06-30 active Selected EC1798 VILVSSGAVGVGCARLGLTERPKAIALKQAVAAVGQGRLMRVYDDLFTTLQQPIAQVLLTRSDLVQRSRYLNVYNT FRELLALGVIPVVNENDTVAVDELKFGDNDTLSALVASLVEADWLFLLTDVDRLYSADPRSVPDARPISLVTSIK ELADLQVQTGSQGSQWGTGGMMTKISAARIAIAAGVRTVITQGRYPRNIEKIIQGELIGTHFQPQPEPTSARKRW IAYGLVPVGKLYLDSGAIAAIVKAGKSLLPAGVKTVAGEFEPQDAVQLCDPQGNEIARGLVNYSSNDLQKICGRH SKEIPTILGYVGAETVIHRDNLVLT Nostoc sp. NYSGXRC-6297e SGX Pharmaceuticals 2004-11-20 active Selected Cloned Expressed Soluble EC1798 GENBANK NP_242371.1 MKRQRIVIKIGSSSLTTKQGALDLEKLEGYVRAIVNLRKAGHEVILISSGAVAAGFSRLGYPVRPTTMAGKQAAAA VGQALLMQHYMERFHQHGIIAAQLLLTRKDFQNQTQYTNAYSALMELLKRGALPIINENDSTSIAELTFGDNDML SALVSGLIHAHTLCILTDVNGLYDANPKTHPNAKRYQYLPTIPDEMLQMGGEAGSNVGTGGMKSKVAAAQTALSL GVDVFIGKASGEHALLDILSGKGDGTYVGNTGDLMEGKTKQWIRLHSPVSGVVRIDQGAERAIMNEGKSLLPAGV TSVHGTFQAGDVVHIWNEQNKVIAKGQVTLSSEQLRKVQGRKSDEAKQLIPLVRDEVVHRDQLVIQEKELNES Bacillus halodurans NYSGXRC-6297f SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC1798 MRVVVSIGGSVLAPGLDADQVDAHADAINELTDAGCEVGAVVGGGGVARDYIGTARELGANEIELDDIGVDVTRLN ARLLIAALGGDAAPSPAEDYEDAGEAMRRGDIAVMGGVVAGQTTDAVSAALAEYTDADLLLYATSVPGVFSADPN EDADAEHFTRMTAGELVDIIADIEMNAGSSAPVDLLAAKLIERSGVRTIVLDGTDPRRIVDAVRFGEHDGTDVIP DGTDNQMTYWADNQE Halobacterium sp. NRC-1 NYSGXRC-6298a SGX Pharmaceuticals 2004-11-29 active Selected Cloned Expressed Soluble EC2262 GENBANK NP_228746.1 VGNIYKRFARVFHEGPYTSFSRRIAKNFAKILENFHIRGKKVLDVACGEGTFAVEIAKQGFKVVGVDLSSEMLKFA RKRAKEESISVVFLKKDMRELDFHEEFDIVTCWFDSLNYLLDYKDLKKTFEKVHEALKTGGAFLFDMNTVYGLLM ANQEGPVYIQQDGKDIFEVQTIEFDLEESVATFYVTVFERKEEELWERFDEIHRERGYRVKEIASALSETGFVFS FYEDLLSKSPLTSYSRRLWCAARKVSAG Thermotoga maritima NYSGXRC-6298b SGX Pharmaceuticals 2004-08-25 active Selected Cloned Expressed Soluble Purified EC2262 ICEDB: T1986 GENBANK NP_268652.1 MLQRDLVNTTGFLRMIMEHNYEKFASVYDAVMDDSLYDLWTDFSLRHLPKSKGRNRLLELACGTGIQSVRFAQAGF DVTGLDLSQDMLAIAKKRAQSAKKKIDFIQGNMLDLSQVGQFDFVTCYSDSICYMQDEVDVGDVFKEVYDVLAND GIFIFDVHSTYQTDECFPGYSYHENADDFAMVWDTYADEAPHSVVHELTFFIQEDDGRFSRFDEVHEERTYELLT YDILLEQAGFKSFKVYADFEDKEPTKTSKRWFFVAYK Streptococcus pyogenes NYSGXRC-6298d SGX Pharmaceuticals 2004-08-10 active Selected Cloned Expressed Soluble Purified EC2262 ICEDB: T1988 GENBANK NP_465010.1 MSYEYFPGFYDRLMDSELYDEWLEFSADFIGDAPKKVLDLACGTAEFALRLSFSGHQVTGVDLSKEMVAVAKEKVA AAEIDLPIIEQDMSKLALKQTFDVVTCFCDSLNYLETEQALEATIQAVSAHLEPNGLFLFDVHSVFKIEQGFKDY SYGDSDEEISTIWNSFPGEHPHSIEHELTFYILGEDDTYNRVDELHKERTYPIATYENLLKKFGFTKIDIYADFS HEKPNKTSERIFFAARK Listeria monocytogenes NYSGXRC-6298e SGX Pharmaceuticals 2004-10-19 active Selected Cloned Expressed Soluble Purified EC2262 ICEDB: T1989 GENBANK NP_816489.1 MAYETFAFVYDEVMDESLYQKWLDFSNRHLPQGTQQILEMACGTGALAVDFAKSGYDVTALDLSEEMLMIASERAF EEEVPVQFVQGNMLDLSEVGQYQAITCFSDSLCYMANRQEVQQVFDEVYQALEEEGTFIFDVHSTYKIDSVFPEY SYHYQTEEFAFLWDSYAGEKEHSIEHFLTFFVKEQETDEHFVRYDELHQERTYSLDNYLRMLESAGFMNVKVYAD FTDEAPTETSERWFFVCQRD Enterococcus faecalis NYSGXRC-6298f SGX Pharmaceuticals 2004-08-10 active Selected Cloned Expressed Soluble Purified EC2262 ICEDB: T1990 GENBANK NP_438269.1 MAKDEVGHNFLARLGKTRLRPGGKKATDWLIANGGFSQDKKVLEVACNMGTTAIGLAKQFGCHIEGVDLDENALAK AQANIEANGLQEKIHVQRANAMKLPFEDESFDIVINEAMLTMLPVEAKKKAIAEYFRVLKPNGLLLTHDVMLVGN DHQTILENMRKAINVTVTPLTKDGWKGIFQESGFRNVDTFSGEMTLLSPKGMIYDEGIFGTLKIIRNAMKAENRE QFKRMFKTFNDPEHKLHFIAVCSQK Haemophilus influenzae NYSGXRC-6298g SGX Pharmaceuticals 2004-06-30 active Selected EC2262 MISNNPNHTEYDTWAWLYNQTMGPEYSQNQLKPLEKILLPQIKPNAKILDLCCGTGQLVQTLINRGYQITGVDNSS EMLNYARKNAPNGQFLLADARYFELPLSFDAAFSTSAALNHIMTIPELQQVFQRVYSALKENGWFLFDINHHQQM QRWWRGKIAEGEIENKYAWMVTPNYNPEERQGYFQVTMFQKKTKPSSARIIKIIWRLLSPILNHNLLYKLRIKLL SVFQAKEKNWQRMDEKYFVRGHIPEEIKIALQQTGFTDIQILTLEGNPTIDDRHSAYFLCRKPVNI Nostoc sp. NYSGXRC-6298h SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC2262 MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGYQVTGLDIS PTALTTAKRRASDAGVDVKFAVGDATKLTGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRPGATLLLSCFS NAMPPDEEWPRSTVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS Mycobacterium tuberculosis NYSGXRC-6298i SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC2262 ICEDB: T1991 GENBANK NP_372115.1 MSQYAEMSLVYDQLTQDQPYEKWFEIVKNHCKDESNILDIGCGTGSLTVQLEALGNVTGMDLSVDMLTVAAQKSAN VNWLEGDMTSFDLQQQFDIITIFCDSLNYLQDETAVIETFINVYHHLTDSGVFIFDVHTVYKMMTLFNNQSYIDD KGDIFLAWDAVQGDLPLSVYHDMTFFIRHEDETYSRFDESHFQRTFDEKTYLSWLAQVGFKHVETFTDFNIDEHN EDTERLFFIAKK Staphylococcus aureus NYSGXRC-6298j SGX Pharmaceuticals 2004-07-19 active Selected EC2262 MSNVDHAEIAKFEALAHRWWDRESEFKPLHDINPLRVNWIDERAGLAGKKVLDIGCGGGILSEAMAQRGASVTGID MGEAPLAVARLHQLESGVAVDYRQITAEQMAEEMPGQFDVVTCLEMLEHVPDPASVIRACHRLVKPGGQVFLSTI NRNPKAYLFAVIGAEYILQLLPRGTHDFRKFIRPSELGAWSREAGLEVKDIIGLTYNPLTKHYKLANDVDVNYMV QTKREA Pseudomonas aeruginosa NYSGXRC-6298k SGX Pharmaceuticals 2004-07-27 active Selected Cloned Expressed Soluble Purified EC2262 ICEDB: T1992 GENBANK NP_242196.1 MNYEMFAKLYDRLMADAPYDRWAKLVEEEIRKAIFSDVNLLDIGCGTGRLLKILSERGYACTGVDQSANMLVIARE ALAQKGVQVPLFQQDMTEFYTGETYQVITIFCDSLNYVITEEGVVQTFQRVFDHLDQQGVFMFDVHSPTKLRNHF IGKTFADADEEISYIWQSFAGEAEQSVEHELTFFVRNETGSYDRYEELHIQRGYPIERYVDWLKEAGFSRIDITA DFTNEAPTENSERIFFKAYKK Bacillus halodurans NYSGXRC-6299a SGX Pharmaceuticals 2004-08-03 active Selected Cloned Expressed Soluble Purified EC949 ICEDB: T1993 GENBANK NP_416278.1 MSENSIRLTQYSHGAGCGCKISPKVLETILHSEQAKFVDPNLLVGNETRDDAAVYDLGNGTSVISTTDFFMPIVDN PFDFGRIAATNAISDIFAMGGKPIMAIAILGWPINKLSPEIAREVTEGGRYACRQAGIALAGGHSIDAPEPIFGL AVTGIVPTERVKKNSTAQAGCKLFLTKPLGIGVLTTAEKKSLLKPEHQGLATEVMCRMNIAGASFANIEGVKAMT DVTGFGLLGHLSEMCQGAGVQARVDYEAIPKLPGVEEYIKLGAVPGGTERNFASYGHLMGEMPREVRDLLCDPQT SGGLLLAVMPEAENEVKATAAEFGIELTAIGELVPARGGRAMVEIR Escherichia coli NYSGXRC-6299b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed EC949 GENBANK NP_816208.1 MDFLSQCTSGGCGAKIESRVLNQLLQHLPETPANERLLVGFEHADDAAVYQITSEKALISTVDFFSPMVNDPLSFG KIAVANALSDVYAMGGTVLYALNLVCFPQKMSKEWLEQMLLGGSLKLKEAGALLAGGHSIYDHEPKYGLAVTGEV HPENLWHNNTPQVGDVLILTKALGVGIIQAAVRGQLAKQTEQKIAQDSMERLNKYAAANARSYAVHACTDVTGFG LLIHAKEMADNQVTLLIDTEALPTITGALAYAAECLVTAAGQRNRQTIGTTIDYSKISMEMQELLFDPQTSGGLL ISVAADEAAACLAAIQKEDPVAKIIGEVLPKEQQAVVLL Enterococcus faecalis NYSGXRC-6299c SGX Pharmaceuticals 2004-07-27 active Selected Cloned Expressed Soluble Purified EC949 ICEDB: T1994 GENBANK NP_213702.1 LKGFNIYTDESTLVSIGDDAGVYEHNGIIWVYTVDIITPVVNDPYLWGAISTANALSDVYAMGGIPVNALAISCFN NCELDIEIFREVIRGALDKLREAKTVLLGGHTIDDKEPKFGLSVAGICPEGKYITQSGAQVGQLLILTKPIGTGI LIKGLKEGILKEEDINEAIENMLALNDKARNLMLSLDATACTDVTGFGLLGHAWNICKNSNIGARIFFEKVPYYQ LSENLVKKKIYPKGAIENLNFVKNYLKSNLDNWKLILLSDPVTSGGLLFTINKEKLEKIDETAKELEVNYWIIGE TIAENVLEVL Aquifex aeolicus NYSGXRC-6299d SGX Pharmaceuticals 2004-08-19 active Selected Cloned Expressed Soluble Purified EC949 ICEDB: T1995 GENBANK YP_001929809.1 MNRSSFDLLSTVEYGGCSAKLDPAKLSELLHDIPLPVDSRIMVDVSTHDDAGVYRLNDDTALIVTTDFFPPVCSDP YTFGRIAAANALSDVYAMGGRPLLVLNLTMFPSEGIPVEVLADILRGGQQTIDESGAFTMGGHTIDDPIPKYGLA VTGIVHPEHLVTNAGVRAGQCLVLTKPLGIGVAMAAHRLGLIGSEVYEAAIGQMCLLNRAGAELMQKYGIRGATD ITGFGLLGHAKGLAEASDVCLHIDSRSVPVLPECLSLLRDGCIPGAAFRNLRFVGDMLRADCPTEYKMLLADAQT SGGLLMAVDADRAEDLVADLHRTGLHPFAAIIGYATDAEDAAKLIVT Porphyromonas gingivalis NYSGXRC-6299e SGX Pharmaceuticals 2004-07-19 active Selected EC949 MSEAIRLTQYSHGAGCGCKISPKVLEVILAGSGAQNLDPKLWVGNASRDDAAVYALDEERGVVSTTDFFMPIVDDP FDFGRIAATNAISDIYAMGGDPLMAIAILGWPVNVLAAEVAREVIAGGRKVCEEAGIPLAGGHSIDAPEPIFGLA VTGVVEKRFMKRNDTAEAGCRLYLTKPLGIGILTTAEKKARLRAEDVGVARDWMCTLNRPGARFGRLAGVKAMTD VTGFGLLGHLVEMADGSKLTARVEYAAVPRLASAEYYLEQGCVPGGTLRNFDSYGERIAPLPEVQKLLLCDPQTS GGLLVAVAPEGEAEFLAVAAELGLQLAPIGELVERQSLAVQVL Pseudomonas aeruginosa NYSGXRC-6299f SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC949 MQKTPALLSDIGNNEDASVYQISPDLALVQTLDFITPIVDSAYHFGAIAAANALSDVFAMGAEVINALNIVGFDTC NHDLNILKELLEGANDKVKECNALVVGGHTIESTELFFGLSVTGKVHPSKFIANNTSKIGDCIILTKPLGTGILS TALKAQMLNQKHLDIMLKNMIELNYKASQIALKFHPSAMSDVTGFGLLGHLKEMLNKNISFEIFESELPFLDGVK EYFNMGLIPAGAYKNLEFIKELTPDLNEEKLLLCDPQTSGGLLISISEKDSLECLKKLEDENIQAKIIAKVVNKQ ENDIIIS Campylobacter jejuni NYSGXRC-6299g SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC949 MSKQAIRLTQYSHGAGCGCKISPKVLETILHSEQAKFVDPNLLVGNETRDDAAVYDLGNGTSIISTTDFFMPIVDN PFDFGRIAATNAISDIFAMGGKPIMAIAILGWPINTLSPDIAREVTEGGRFACRQAGIALAGGHSIDAPEPIFGL AVTGVVPTERVKKNSTAQAGCKLFLTKPLGIGVLTTAEKKSLLKPEHQGLATEVMCRMNVAGAAFANIDGVKAMT DVTGFGLLGHLSEMCQGAGVQAMLCYQDIPKLPGVEEYIALGAVPGGTERNFASYGHLMGDMSREVRSLLCDPQT SGGLLLAVTPDAEDDVKATAAEFGIELTAIGELVEARGGRAMVEIR Salmonella typhi NYSGXRC-6299h SGX Pharmaceuticals 2004-10-15 active Selected Cloned Expressed Soluble Purified EC949 ICEDB: T1996 GENBANK AAC21869.1 VLGTILHSELEKFYDPNLIVGNETADDAAVYDLGNGTAIISTTDFFMPIVDDPFDFGRIAATNAISDIFAMGGKPI MGIAILGFPTNVLPAEVAQKIVDGGRFACHQAGIALAGGHSIDSPEPIFGLAVTGVIDTEKVKRNASAKSGCKLY MTKPLGIGILTTAEKKGKLKPEHQGLATAAMCQMNSIGSQFSQVDGVTAMTDVTGFGLLGHLIEICEGSNLSAVV FSDKIKTLDGVKDYIAQGCVPGGTGRNFDSYGHKVGILTEEQKAILCDPQTSGGLLVAVELNSVQTVIDIAKDAG IDLYEVGKLKPKSESDIVVEVK Haemophilus influenzae NYSGXRC-6300a SGX Pharmaceuticals 2004-06-30 active Selected Cloned EC3401 MEYEKSASGSVYLLGRMDTTQVTLIHKILAAADERNLPLWIGGGWAIDARLGRVTRKHDDIDLTFPGERRGELEAI VEMLGGRVMEELDYGFLAEIGDELLDCEPAWWADEAYEIAEAPQGSCPEAAEGVIAGRPVRCNSWEAIIWDYFYY ADEVPPVDWPTKHIESYRLACTSLGAEKVEVLRAAFRSRYAA Escherichia coli NYSGXRC-6300b SGX Pharmaceuticals 2004-06-30 active Selected EC3401 MESVHIHVHSEYTLLSSMCRIPALVEKAKAAQFSALALTDRHVMYGAVPFYKACKESGLKPIIGMETTVRFAEDRE SDLLLYARSNKGYEHLLKLSTIIQCREEKEKYVTWEELLAYKDDLLYVIPYSGGFVRACLEDEALERGERFIQFL KDHLGGESVYLEIQGTDRSKVEPINQLAAKLAIPLVCSQHIQVLEREDLDAWKVIQAIREGVLVEELRIEQEEDV CFFTLTEMEQTFRAYPEALQNTKKLADRCHVELTLGKPRLPKFQTPNEQSAEDYLRKLCEQGAKERYGEEWTKEK AQRLGEELAVIERMGFSDYFLIVWDFMRFAREASIVTGPGRGSVAGSLVAYVLFITDVDPLHYDLLFERFLNPER ISLPDIDLDFPDHRREEVIVYVKKKYGANRVAQILTFGTLAARASVRDVGKALAIPPNVIEKISKEISGRPGMTL VKAYNENERLRQLVHASDEAQKVMKLARKVEGLPRHTSTHAAGVVISEQPLTEVIALQHGQGEVPLTQGTMETVE DVGLIKMDFLGLRNLTLLEMVVKRVRETYGHSLNVKQLPLNDAKTFALLAKGETTGVFQLESGGMRKVLRELKPN TFADIVAVNALYRPGPMEFIPDYIQGKEGTKEITYLHPDLEPILSSTYGVIVYQEQIMQIAAKMAGFSLGEADLL RRAISKKKGEALRQQEEAFVTGAVRQGYEQETAKKIYELIVRFANYGFNKSHAVAYSMLAYQLAYLKAHYPSSFY AALASTIWNQPEKLERLLQEMKQQGIRVLPPSLSKSDIHFSEEEEGVRFPLLPLRYVSVRAIRELIKARREAPVR SLFDLCSRVDGRIVTSRVMESLIKAGALDELGERATLLANIEEAFQFAEQVKEFQENTGGLFQLSVEEPEYIKVE PLTDLEKLAYEKEAVGFYLSGHPLLAYTESLRQYDRLTYLEGTERRFVKLAGMIHRIRRIRTKRGEVMGFLTMSD ETGEWEAVVFPAVWAMYEWGLKEGELYFVEGKMDRGRSEELQLLVDKVLPLKHMLKKEKEKLFLKITADVEKEVE RLNDIRRLLQVHHGPTPVVMYYEKQRKTIQLPEKYHVSLSFTLLHELEQLVGKEHVVVSTYEDES Bacillus halodurans NYSGXRC-6301a SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC1035 MNNWQHFFNNPVDLSEHLKKPYFRFDNRDKEITAISFDEKANLIWSGDSYGCISSYDPTFQLYTRYRGHIGGNSVK DILSHRDGILSISEDSLHFANRRGVTKLNLTSIDIAAFSELNTMCYSPHSLKNNIYCGGDNTNWGIASIDLNRGC LDSLLNYSSKVKLMCSNNKVLSIGRQTGTVDLLDPTSNRTIKSFNAHSASISAMDLRDNTLVTVGKSKRFYNLYA DPFVNVYDLRTMRQLPPVSFSKGTTMGSGGADFVQLHPLLPTVMIVASSSGSFDFIDLSNPTLRTQYVHPCQSIK KLCLSPNGDVLGILEADNHLDTWRRSSNNMGMFTNTPEMLAYPDYFNDITSDGPISVDDETYPLSSVGMPYYLDK LLSAWPPVVFKSEGTIPQLTGKSPLPSSGKLKSNLAVISSQNEKLSTQEFPLLRYDRTKYGMRNAIPDYVCLRDI RKQITSGLETSDIQTYTSINKYEVPPAYSRLPLTSGRFGTDNFDFTPFNNTEYSGLDPDVDNHYTNAIIQLYRFI PEMFNFVVGCLKDENFETTLLTDLGYLFDMMERSHGKICSSSNFQASLKSLTDKRQLENGEPQEHLEEYLESLCI RESIEDFNSSESIKRNMPQKFNRFLLSQLIKEEAQTVNHNITLNQCFGLETEIRTECSCDHYDTTVKLLPSLSIS GINKTVIKQLNKKSNGQNILPYIEYAMKNVTQKNSICPTCGKTETITQECTVKNLPSVLSLELSLLDTEFSNIRS SKNWLTSEFYGSIIKNKAVLRSTASELKGTSHIFKYELNGYVAKITDNNNETRLVTYVKKYNPKENCFKWLMFND YLVVEITEEEALKMTYPWKTPEIIIYCDAEELRKPFFSVDTYSINYDILFRDYFANGIRDTARREYKLLTHDEAP KSGTLVAIDAEFVSLQSELCEIDHQGIRSIIRPKRTALARISIIRGEEGELYGVPFVDDYVVNTNHIEDYLTRYS GILPGDLDPEKSTKRLVRRNVVYRKVWLLMQLGCVFVGHGLNNDFKHININVPRNQIRDTAIYFLQGKRYLSLRY LAYVLLGMNIQEGNHDSIEDAHTALILYKKYLHLKEKAIFEKVLNSVYEEGRAHNFKVPETSKG Saccharomyces cerevisiae NYSGXRC-6301b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC1035 MDAWKEITKTTENDGVSTCSLSSIAFDPYSELVWTGHKNGQIKSSFGPSLTSYTQFIGHEGPVHQVLPQERGVFSL SSKSLRLSNRKGTIRWRYHSVPCVQRSMIILYSCFLCSKHAVLISRDSDCIDYRAMFYQSRNNPEVVIGGYHQKL TVVNAERGISIHKDKNVSDIFIMRRNRLLCCGSTNGEIILRDPNSFQPVNKVVAHTGTISDIDTSGNLLLSCGYS LRHGTYMLDPFVKVWDLRNLSSLVPIPFPAGPTIIRMHPKLSTTAVVCSCSGQFHIVDTGNPLDAKLMQIPLTSY LTGMDIASTGDAMVFTDVEDNIHLWSPLENPSFSDLKLPIQLPNTSTETVQLENNDPLNSIGLPYYKDELLSSWS KYLIFDVGKPILDSNLLIAKQISENSHPVPQEIKSFHRNQIIEVPWLNRKLISEGATPKFHSERQKDIMSGNDIE GSASYFEEIEDTISGPDSIPKFYQRPVIKYSKFGIEDFDFGFYNKTKYAGLETDITNSYCNSVLQLLSYVPSFSK AAISHSLGPCDLMECLLCELGFLFAMLKESTGRNCQATNFLRAFSNSSFAQSLGIVFDDYSDGTFPDSFVIQKFT KFMLTEISRIADYEDKKDGTSFPVSFLLKSFCIPEMQTYRCGICGITSQKIKSSLYIIDLHYPSQQLESILSFEW LFKMSLDRRVDLPPGWCEYCLAHQPFLLRSFIRSLPDCLFINTQVKHHEHWKLWARKNWLPKKLHLRRVNDTMQC VSQKISNLDKDQQSLSVYVLRGIIYEIRQNGEEPHFVSTIRVSDNTSSDNPDDNRWYIFNDFLVKEVTEEEALTV HGPWKIPIIVYYEKLDTKIPQWDEVSDYTLLYQPYSLNKNPPINKIQPLTTDEMLYPKMLVGIDSEFVALQQEET EVRSDGTKSTIKPSKLSLARVSVLRGEGPNKGLPFIDDYVATDDKVTDYLTEYSGIHPGDLDPDRSPYNVVPLKV AYKKLRLLVNAGCIFVGHGLQKDFRIINLLVPPEQVVDTVDLFFLSSRQRKLSLKFLAWYLLDEEIQLTEHDSIE DALTALKLYDCYDKLKSQGKLEETLDNIYEVGRRFKFRPPSVASMSLEDRNSYGDESVISNQTN Schizosaccharomyces pombe NYSGXRC-6302a SGX Pharmaceuticals 2004-07-19 active Selected Cloned EC824 MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSKQFKDGEWLYHISPKSG FIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVP KTGLGSSAGLVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAARYGSIRYRRFPPAL ISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYTE LDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPV QTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQPLMTKDF Saccharomyces cerevisiae NYSGXRC-6302b SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed Soluble EC824 MKVTCSAPGKVLIAGGYIVLDPQYSGLVIGLTAKGYASTTTLDDKCGTVRVKSPQFINAEWLYNIDWTVSPIRVHQ IYENCELEKNPNPFVQLALFYVINYFFSTGRQPLCWQDLQVTLQVDNAYYHQPQLKPDQTSYPKFNFLNCTLGQV HKTGLGSSAAMITSLIGSLFLSLRRLTDDTGDKSLKIDDSTKVIVHNLAQIAHCSAQGKVGSGFDVGAATWGSCI YRRFDPKLIEQLLVPYDEQIKNINFSTELRKIVSKKWSDVVPFQLPATYCLLMGDVAGGSSTPGMVKKVQQWQKE NPEESKNCFDDLYSRVLSIKNCFLSSESLDSELQSQFRSIRRILQRITVEAKVDIEPLKQTNILDNIEQLPGVIG VGVPGAGGFDAQFCLAINHTEIIENVIKTWKDDGVVPMDVSPAFDGLAVE Schizosaccharomyces pombe NYSGXRC-6303a SGX Pharmaceuticals 2004-07-19 active Selected Cloned Expressed EC1091 GENBANK NP_414805.1 MEITNPILTGFNPDPSLCRQGEDYYIATSTFE